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Objectives: COVID-19, a novel Coronavirus from same family as SARS-CoV-2 is a highly contagious virus. It is transmitted mainly from upper respiratory system and affects important organs, like heart and lungs. The aim of this study is identifying appropriate therapeutic methods originated from persian medicine. Materials and Methods: This study has been designed from the viewpoints of traditional and modern medicine. Considering modern medicine, we searched valid database by searching key words “SARS-Cov-2” and “COVID-19”. For traditional medicine, we searched reliable traditional medicine like the “Canon of Medicine” by “Avicenna”, the Exir-e Aazam and Zakhira-I Kharazm Shahi. Patients were evaluated according to their symptoms and categorized based on traditional medicine. Physiopathology and management of the disease, including prevention and treatment were studied. Results: The principle underlying mechanism seems to be warm and dry dystemperament that affects different organs and causes various adverse effects which are higher than warm and dry dystemperament, but less than the presence of virus. Our traditional Iranian medicine findings are validated by the modern medicine. Conclusion: Based on symptoms, the equivalent of this disease was examined from the viewpoint of traditional medicine. Then, physiopathology and management of this disease were presented in five levels, including one stage of prevention and four stages of treatment, and finally, the treatment recommendations of Iranian traditional medicine were approved with new research results. [ABSTRACT FROM AUTHOR]