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1,114 results on '"Amin-Hanjani, Sepideh"'

1. Co-mapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy

Author

Tobe, Yasutaka, Robertson, Anne, Ramezanpour, Mehdi, Cebral, Juan, Watkins, Simon, Charbel, Fady, Amin-Hanjani, Sepideh, Yu, Alexander, Cheng, Boyle, and Woo, Henry

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Deviation of blood flow from an optimal range is known to be associated with the initiation and progression of vascular pathologies. Important open questions remain about how the abnormal flow drives specific wall changes in pathologies such as cerebral aneurysms where the flow is highly heterogeneous and complex. This knowledge gap precludes the clinical use of readily available flow data to predict outcomes and improve treatment of these diseases. As both flow and the pathological wall changes are spatially heterogeneous, a crucial requirement for progress in this area is a methodology for co-mapping local data from vascular wall biology with local hemodynamic data. In this study, we developed an imaging pipeline to address this pressing need. A protocol that employs scanning multiphoton microscopy was designed to obtain 3D data sets for smooth muscle actin, collagen and elastin in intact vascular specimens. A cluster analysis was developed to objectively categorize the smooth muscle cells (SMC) across the vascular specimen based on SMC density. In the final step in this pipeline, the location specific categorization of SMC, along with wall thickness was co-mapped with patient specific hemodynamic results, enabling direct quantitative comparison of local flow and wall biology in 3D intact specimens., Comment: 36 pages, 5 figures

Published
2023

2. Risk of Early Versus Later Rebleeding From Dural Arteriovenous Fistulas With Cortical Venous Drainage

Author

Durnford, Andrew J, Akarca, Danyal, Culliford, David, Millar, John, Guniganti, Ridhima, Giordan, Enrico, Brinjikji, Waleed, Chen, Ching-Jen, Abecassis, Isaac Josh, Levitt, Michael, Polifka, Adam J, Derdeyn, Colin P, Samaniego, Edgar A, Kwasnicki, Amanda, Alaraj, Ali, Potgieser, Adriaan RE, Chen, Stephanie, Tada, Yoshiteru, Phelps, Ryan, Abla, Adib, Satomi, Junichiro, Starke, Robert M, van Dijk, J Marc C, Amin-Hanjani, Sepideh, Hayakawa, Minako, Gross, Bradley, Fox, W Christopher, Kim, Louis, Sheehan, Jason, Lanzino, Giuseppe, Kansagra, Akash P, Du, Rose, Lai, Rosalind, Zipfel, Gregory J, Bulters, Diederik O, Piccirillo, Jay F, Raman, Hari, Lipsey, , Kim, Vine, Roanna, Cloft, Harry J, Kallmes, David F, Pollock, Bruce E, Link, Michael J, Patibandla, Mohana Rao, Ding, Dale, Buell, Thomas, Paisan, Gabriella, Meyer, R Michael, Kelly, , Cory, Duffill, Jonathan, Ditchfield, Adam, Macdonald, Jason, Laurent, Dimitri, Hoh, Brian, Smith, Jessica, Lockerman, Ashley, Lunsford, L Dade, Jankowitz, Brian T, Gutierrez, Santiago Ortega, Hasan, David, Roa, Jorge A, Rossen, James, Guerrero, Waldo, McGruder, Allen, Charbel, Fady T, Aletich, Victor A, Rose-Finnell, Linda, Peterson, Eric C, Yavagal, Dileep R, Sur, Samir, Kanematsu, Yasuhisa, Yamamoto, Nobuaki, Kinouchi, Tomoya, Korai, Masaaki, Yamaguchi, Izumi, Yamamoto, Yuki, Winkler, Ethan, Lawton, Michael, Rutkowski, Martin, Sultan, M Ali Aziz, Patel, Nirav, and Frerichs, Kai U

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Kidney Disease, Central Nervous System Vascular Malformations, Cerebral Angiography, Drainage, Embolization, Therapeutic, Humans, Outcome Assessment, Health Care, drainage, fistula, hemorrhage, incidence, natural history, CONDOR Investigators, Cardiorespiratory Medicine and Haematology, Neurosciences, Neurology & Neurosurgery, Clinical sciences, Allied health and rehabilitation science
Abstract

BackgroundCranial dural arteriovenous fistulas with cortical venous drainage are rare lesions that can present with hemorrhage. A high rate of rebleeding in the early period following hemorrhage has been reported, but published long-term rates are much lower. No study has examined how risk of rebleeding changes over time. Our objective was to quantify the relative incidence of rebleeding in the early and later periods following hemorrhage.MethodsPatients with dural arteriovenous fistula and cortical venous drainage presenting with hemorrhage were identified from the multinational CONDOR (Consortium for Dural Fistula Outcomes Research) database. Natural history follow-up was defined as time from hemorrhage to first treatment, rebleed, or last follow-up. Rebleeding in the first 2 weeks and first year were compared using incidence rate ratio and difference.ResultsOf 1077 patients, 250 met the inclusion criteria and had 95 cumulative person-years natural history follow-up. The overall annualized rebleed rate was 7.3% (95% CI, 3.2-14.5). The incidence rate of rebleeding in the first 2 weeks was 0.0011 per person-day; an early rebleed risk of 1.6% in the first 14 days (95% CI, 0.3-5.1). For the remainder of the first year, the incidence rate was 0.00015 per person-day; a rebleed rate of 5.3% (CI, 1.7-12.4) over 1 year. The incidence rate ratio was 7.3 (95% CI, 1.4-37.7; P, 0.026).ConclusionsThe risk of rebleeding of a dural arteriovenous fistula with cortical venous drainage presenting with hemorrhage is increased in the first 2 weeks justifying early treatment. However, the magnitude of this increase may be considerably lower than previously thought. Treatment within 5 days was associated with a low rate of rebleeding and appears an appropriate timeframe.

Published
2022

5. Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage: Review and Expert Consensus on Clinical Translation

Author

Galea, Ian, Bandyopadhyay, Soham, Bulters, Diederik, Humar, Rok, Hugelshofer, Michael, Schaer, Dominik J., Abdulazim, Amr, Alalade, Andrew F., Alexander, Sheila A., Amaro, Sergi, Amin-Hanjani, Sepideh, Andersen, Christopher R., Anderson, Craig, Anstey, Matthew H., Balla, József, Bankole, Nourou Dine Adeniran, Bellapart, Judith, Bhagat, Hemant, Blackburn, Spiros L., Brechmann, Markus, Buehler, Paul W., Burkhardt, Jan-Karl, Chen, Yujie, Cohen, Jeremy, Cooper, P. David, Coulthard, Liam G., Cuadrado-Godia, Elisa, Dalton, Joan, Delaney, Anthony, Doré, Sylvain, Downer, Jonathan, Dye, Justin, Fernandez-Perez, Isabel, Flower, Oliver, Fülesdi, Béla, Gaastra, Ben, Gaberel, Thomas, Galea, James, Gankpe, Gbetoho Fortuné, Garland, Patrick, Gentinetta, Thomas, Gram, Magnus, Graversen, Jonas Heilskov, Grover, Patrick J., Guisado-Alonso, Daniel, Hasan, David, Helmy, Adel, Höhne, Julius, Charlotte Hostettler, Isabel, Hrishi, Ajay Prasad, Iihara, Koji, Irwin, David C., Jangra, Kiran, Jiménez-O’Shanahan, Aruma, Keep, Richard F., Koch, Matthew, Korja, Miikka, Kumar, Munish, Llull, Laura, Loan, James JM, Lopez-Gonzalez, Miguel Ángel, Loch Macdonald, R., Mahajan, Shalvi, Martí-Fàbregas, Joan, Medina-Suárez, Jose, Moestrup, Soren, More, John, Morgan, Eghosa, Muthuchellappan, Radhakrishnan, Nyquist, Paul, Sosa Pérez, Coralia, Pillai, Promod, Plesnila, Nikolaus, Javier Provencio, Jose, Raith, Eamon, Ramos-Pachón, Anna, Raymond, Scott B., Regli, Luca, Ruigrok, Ynte Marije, Saharan, Poonam, Samaniego, Edgar A., Schubert, Gerrit Alexander, Seppelt, Ian, Sriganesh, Kamath, Suarez, Jose I., Taylor, Jonathon, Terpolilli, Nicole A., Testai, Fernando D., Tolosano, Emanuela, Toma, Ahmed K., On Tsang, Anderson Chun, Udy, Andrew A., Vallelian, Florence, Vargas-Caballero, Mariana, Vercellotti, Gregory M, Vergouwen, Mervyn D.I., Waak, Michaela, Warming, Hannah, Whitfield, Peter C., Kwok-chu Wong, George, Wright, Jason, and Zuercher, Adrian W.

Published
2023
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6. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association

Author

Hoh, Brian L., Ko, Nerissa U., Amin-Hanjani, Sepideh, Hsiang-Yi Chou, Sherry, Cruz-Flores, Salvador, Dangayach, Neha S., Derdeyn, Colin P., Du, Rose, Hänggi, Daniel, Hetts, Steven W., Ifejika, Nneka L., Johnson, Regina, Keigher, Kiffon M., Leslie-Mazwi, Thabele M., Lucke-Wold, Brandon, Rabinstein, Alejandro A., Robicsek, Steven A., Stapleton, Christopher J., Suarez, Jose I., Tjoumakaris, Stavropoula I., and Welch, Babu G.

Published
2023
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9. Neuropsychological Test Performance Differentiates Subgroups of Individuals With Adult Moyamoya Disease: A Cross-Sectional Clinical Study

Author

DeDios-Stern, Samantha L., primary, Gotra, Milena Y., additional, Resch, Zachary J., additional, Jennette, Kyle J., additional, Amin-Hanjani, Sepideh, additional, Charbel, Fady T., additional, Alaraj, Ali, additional, Testai, Fernando D., additional, Thulborn, Keith R., additional, Vargas, Alejandro, additional, Pliskin, Neil H., additional, and Soble, Jason R., additional

Published
2024
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10. Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in ACom and MCA aneurysms

Author

Karnam, Yogesh, primary, Mut, Fernando, additional, Yu, Alexander K., additional, Cheng, Boyle, additional, Amin‐Hanjani, Sepideh, additional, Charbel, Fady T., additional, Woo, Henry H., additional, Niemelä, Mika, additional, Tulamo, Riikka, additional, Jahromi, Behnam Rezai, additional, Frösen, Juhana, additional, Tobe, Yasutaka, additional, Robertson, Anne M., additional, and Cebral, Juan R., additional

Published
2024
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11. Federal and foundational research funding trends for cerebrovascular neurosurgeons: the decline of the cerebrovascular surgeon-scientist?

Author

Pugazenthi, Sangami, primary, Srienc, Anja I., additional, Cantu, Luke, additional, Huguenard, Anna L., additional, Eskandar, Emad, additional, Mack, William J., additional, Amin-Hanjani, Sepideh, additional, Vellimana, Ananth K., additional, Osbun, Joshua W., additional, and Zipfel, Gregory J., additional

Published
2024
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12. Large Vessel Occlusion Stroke due to Intracranial Atherosclerotic Disease: Identification, Medical and Interventional Treatment, and Outcomes

Author

de Havenon, Adam, Zaidat, Osama O., Amin-Hanjani, Sepideh, Nguyen, Thanh N., Bangad, Aaron, Abbasi, Mehdi, Anadani, Mohammad, Almallouhi, Eyad, Chatterjee, Rano, Mazighi, Mikael, Mistry, Eva A., Yaghi, Shadi, Derdeyn, Colin P., Hong, Keun-Sik, Kvernland, Alexandra, Leslie-Mazwi, Thabele M., and Al Kasab, Sami

Published
2023
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14. Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions.

Author

Karnam, Yogesh, Mut, Fernando, Yu, Alexander K., Cheng, Boyle, Amin‐Hanjani, Sepideh, Charbel, Fady T., Woo, Henry H., Niemelä, Mika, Tulamo, Riikka, Jahromi, Behnam Rezai, Frösen, Juhana, Tobe, Yasutaka, Robertson, Anne M., and Cebral, Juan R.

Subjects
INTRACRANIAL aneurysms, BLOOD flow, FINITE element method, SHEARING force, ANEURYSMS
Abstract

Intracranial aneurysms (IAs) pose severe health risks influenced by hemodynamics. This study focuses on the intricate characterization of hemodynamic conditions within the IA walls and their influence on bleb development, aiming to enhance understanding of aneurysm stability and the risk of rupture. The methods emphasized utilizing a comprehensive dataset of 359 IAs and 213 IA blebs from 268 patients to reconstruct patient‐specific vascular models, analyzing blood flow using finite element methods to solve the unsteady Navier–Stokes equations, the segmentation of aneurysm wall subregions and the hemodynamic metrics wall shear stress (WSS), its metrics, and the critical points in WSS fields were computed and analyzed across different aneurysm subregions defined by saccular, streamwise, and topographical divisions. The results revealed significant variations in these metrics, correlating distinct hemodynamic environments with wall features on the aneurysm walls, such as bleb formation. Critical findings indicated that regions with low WSS and high OSI, particularly in the body and central regions of aneurysms, are prone to conditions that promote bleb formation. Conversely, areas exposed to high WSS and positive divergence, like the aneurysm neck, inflow, and outflow regions, exhibited a different but substantial risk profile for bleb development, influenced by flow impingements and convergences. These insights highlight the complexity of aneurysm behavior, suggesting that both high and low‐shear environments can contribute to aneurysm pathology through distinct mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy

Author

Tobe, Yasutaka, primary, Robertson, Anne M, additional, Ramezanpour, Mehdi, additional, Cebral, Juan R, additional, Watkins, Simon C, additional, Charbel, Fady T, additional, Amin-Hanjani, Sepideh, additional, Yu, Alexander K, additional, Cheng, Boyle C, additional, and Woo, Henry H, additional

Published
2024
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18. Dural arteriovenous fistulas are not observed to convert to a higher grade after partial embolization

Author

Walker, Erin, primary, Srienc, Anja, additional, Lew, Daphne, additional, Guniganti, Ridhima, additional, Lanzino, Giuseppe, additional, Brinjikji, Waleed, additional, Hayakawa, Minako, additional, Samaniego, Edgar A., additional, Derdeyn, Colin P., additional, Du, Rose, additional, Lai, Rosalind, additional, Sheehan, Jason P., additional, Starke, Robert M., additional, Abla, Adib, additional, Abdelsalam, Ahmed, additional, Gross, Bradley, additional, Albuquerque, Felipe, additional, Lawton, Michael T., additional, Kim, Louis J., additional, Levitt, Michael, additional, Amin-Hanjani, Sepideh, additional, Alaraj, Ali, additional, Winkler, Ethan, additional, Fox, W. Christopher, additional, Polifka, Adam, additional, Hall, Samuel, additional, Bulters, Diederik, additional, Durnford, Andrew, additional, Satomi, Junichiro, additional, Tada, Yoshiteru, additional, van Dijk, J. Marc C., additional, Potgieser, Adriaan R. E., additional, Chen, Ching-Jen, additional, Becerril-Gaitan, Andrea, additional, Osbun, Joshua W., additional, and Zipfel, Gregory J., additional

Published
2024
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19. Abstract TMP6: Dural Arteriovenous Fistulas With Cognitive Impairment: Angiographic Characteristics and Treatment Outcomes

Author

Sanchez, Sebastian, primary, Ojeda, Diego, additional, Sagues, Elena, additional, Gudino, Andres S, additional, Saleem, Arshaq, additional, Wendt, Linder, additional, Hayakawa, Minako, additional, Chen, Ching-Jen, additional, Sheehan, Jason, additional, Kim, Louis, additional, Abecassis, Isaac, additional, Levitt, Michael, additional, Meyer, R Michael, additional, Guniganti, Ridhima, additional, Kansagra, Akash P, additional, Lanzino, Giuseppe S, additional, Giordan, Enrico, additional, Brinjikji, Waleed, additional, Bulters, Diederik, additional, Durnford, Andrew, additional, Fox, W Christopher, additional, Smith, Jessica, additional, Polifka, Adam, additional, Gross, Bradley, additional, Amin-Hanjani, Sepideh, additional, Alaraj, Ali, additional, Kwasnicki, Amanda, additional, Starke, Robert, additional, Chen, Stephanie H, additional, van Dijk, J Marc C, additional, Potgieser, Adriaan R, additional, Satomi, Junichiro, additional, Tada, Yoshiteru, additional, Phelps, Ryan, additional, Abla, Adib, additional, Winkler, Ethan, additional, Du, Rose, additional, Lai, Pui Man Rosalind, additional, Ortega-Gutierrez, Santiago, additional, Zipfel, Gregory J, additional, Derdeyn, Colin P, additional, and Samaniego, Edgar A, additional

Published
2024
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22. Contributors

Author

Adams, Harold P., primary, Adeoye, Opeolu, additional, Albers, Gregory W., additional, Alexandrov, Andrei V., additional, Amin-Hanjani, Sepideh, additional, An, Hongyu, additional, Anderson, Craig S., additional, Anrather, Josef, additional, Aparicio, Hugo J., additional, Arai, Ken, additional, Aronowski, Jaroslaw, additional, Atchaneeyasakul, Kunakorn, additional, Audebert, Heinrich, additional, Auer, Roland N., additional, Awad, Issam A., additional, Ay, Hakan, additional, Baltan, Selva, additional, Balu, Ramani, additional, Behbahani, Mandana, additional, Benavente, Oscar R., additional, Bershad, Eric M., additional, Berthaud, Jimmy V., additional, Blackburn, Spiros L., additional, Bonati, Leo H., additional, Bösel, Julian, additional, Bousser, Marie Germaine, additional, Broderick, Joseph P., additional, Brown, Martin M., additional, Brown, Wendy, additional, Brust, John C.M., additional, Bushnell, Cheryl, additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Carrión-Penagos, Julián, additional, Castellanos, Mar, additional, Caunca, Michelle R., additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Chen, Jieli, additional, Chen, Jun, additional, Chopp, Michael, additional, Christorforids, Greg, additional, Connolly, E. Sander, additional, Cramer, Steven C., additional, Cucchiara, Brett L., additional, Czap, Alexandra L., additional, Dannenbaum, Mark J., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Silva, T. Michael, additional, de Sousa, Diana Aguiar, additional, Del Brutto, Victor J., additional, del Zoppo, Gregory J., additional, Derdeyn, Colin P., additional, Di Tullio, Marco R., additional, Diener, Hans Christoph, additional, Diringer, Michael N., additional, Dobkin, Bruce H., additional, Dzialowski, Imanuel, additional, Elkind, Mitchell S.V., additional, Elm, Jordan, additional, Feigin, Valery L., additional, Ferro, José Manuel, additional, Field, Thalia S., additional, Fischer, Marlene, additional, Fornage, Myriam, additional, Furie, Karen L., additional, Garcia-Bonilla, Lidia, additional, Giannotta, Steven L., additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Greer, David M., additional, Grotta, James C., additional, Guo, Ruiming, additional, Gutierrez, Jose, additional, Harmel, Peter, additional, Howard, George, additional, Howard, Virginia J., additional, Hwang, Jee-Yeon, additional, Iadecola, Costantino, additional, Jahan, Reza, additional, Jickling, Glen C., additional, Joutel, Anne, additional, Kasner, Scott E., additional, Katan, Mira, additional, Kellner, Christopher P., additional, Khan, Muhib, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Jong S., additional, Kircher, Charles E., additional, Krings, Timo, additional, Krishnamurthi, Rita V., additional, Kurth, Tobias, additional, Lansberg, Maarten G., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Liew, Sook-Lei, additional, Lin, David J., additional, Lisle, Benjamin, additional, Lo, Eng H., additional, Lyden, Patrick D., additional, Maki, Takakuni, additional, Maragkos, Georgios A., additional, Marosfoi, Miklos, additional, McCullough, Louise D., additional, Meckler, Jason M., additional, Meschia, James Frederick, additional, Messé, Steven R., additional, Mocco, J, additional, Mokin, Maxim, additional, Mooney, Michael A., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Mullen, Michael T., additional, Nägel, Steffen, additional, Nedergaard, Maiken, additional, Neira, Justin A., additional, Newman, Sarah, additional, Nicholson, Patrick J., additional, Norrving, Bo, additional, O’Donnell, Martin, additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Orrù, Emanuele, additional, Ortega-Gutiérrez, Santiago, additional, Padrick, Matthew Maximillian, additional, Parsha, Kaushik, additional, Parsons, Mark, additional, Patel, Neil V., additional, Patel, Virendra I., additional, Pawlikowska, Ludmila, additional, Pérez, Adriana, additional, Perez-Pinzon, Miguel A., additional, Picard, John M., additional, Polster, Sean P., additional, Powers, William J., additional, Puetz, Volker, additional, Putaala, Jukka, additional, Rabinovich, Margarita, additional, Ransom, Bruce R., additional, Roa, Jorge A., additional, Rosenberg, Gary A., additional, Rossitto, Christina P., additional, Rundek, Tatjana, additional, Russin, Jonathan J., additional, Sacco, Ralph L., additional, Safouris, Apostolos, additional, Samaniego, Edgar A., additional, Sansing, Lauren H., additional, Satani, Nikunj, additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Schmidt, Christian, additional, Seshadri, Sudha, additional, Sharma, Vijay K., additional, Sharp, Frank R., additional, Sheth, Kevin N., additional, Siddiqi, Omar K., additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Sommer, Clemens J., additional, Spetzler, Robert F., additional, Stapleton, Christopher J., additional, Strickland, Ben A., additional, Su, Hua, additional, Suarez, José I., additional, Takayama, Hiroo, additional, Tarsia, Joseph, additional, Tatlisumak, Turgut, additional, Thomas, Ajith J., additional, Thompson, John W., additional, Tsivgoulis, Georgios, additional, Tournier-Lasserve, Elizabeth, additional, Vidal, Gabriel, additional, Wakhloo, Ajay K., additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wong, Lawrence K.S., additional, Xi, Guohua, additional, Xu, Jinchong, additional, Yaghi, Shadi, additional, Yamaguchi, Takenori, additional, Yang, Tuo, additional, Yasaka, Masahiro, additional, Zahuranec, Darin B., additional, Zhang, Feng, additional, Zhang, John H., additional, Zheng, Zhitong, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2022
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30. Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease

Author

Amin-Hanjani, Sepideh, Pandey, Dilip K, Rose-Finnell, Linda, Du, Xinjian, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell SV, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, and Charbel, Fady T

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Stroke, Brain Disorders, Clinical Trials and Supportive Activities, Clinical Research, Cardiovascular, Aged, Cerebrovascular Circulation, Cohort Studies, Female, Humans, Intracranial Arteriosclerosis, Ischemic Attack, Transient, Magnetic Resonance Angiography, Male, Middle Aged, Prospective Studies, Risk Factors, Vertebrobasilar Insufficiency, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke Study Group, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ImportanceAtherosclerotic vertebrobasilar (VB) occlusive disease is a significant etiology of posterior circulation stroke, with regional hypoperfusion as an important potential contributor to stroke risk.ObjectiveTo test the hypothesis that, among patients with symptomatic VB stenosis or occlusion, those with distal blood flow compromise as measured by large-vessel quantitative magnetic resonance angiography (QMRA) are at higher risk of subsequent posterior circulation stroke.Design, setting, and participantsA prospective, blinded, longitudinal cohort study was conducted at 5 academic hospital-based centers in the United States and Canada; 82 patients from inpatient and outpatient settings were enrolled. Participants with recent VB transient ischemic attack or stroke and 50% or more atherosclerotic stenosis or occlusion in vertebral and/or basilar arteries underwent large-vessel flow measurement in the VB territory using QMRA. Physicians performing follow-up assessments were blinded to QMRA flow status. Follow-up included monthly telephone calls for 12 months and biannual clinical visits (for a minimum of 12 months, and up to 24 months or the final visit). Enrollment took place from July 1, 2008, to July 31, 2013, with study completion on June 30, 2014; data analysis was performed from October 1, 2014, to April 10, 2015.ExposureStandard medical management of stroke risk factors.Main outcomes and measuresThe primary outcome was VB-territory stroke.ResultsOf the 82 enrolled patients, 72 remained eligible after central review of their angiograms. Sixty-nine of 72 patients completed the minimum 12-month follow-up; median follow-up was 23 (interquartile range, 14-25) months. Distal flow status was low in 18 of the 72 participants (25%) included in the analysis and was significantly associated with risk for a subsequent VB stroke (P = .04), with 12- and 24-month event-free survival rates of 78% and 70%, respectively, in the low-flow group vs 96% and 87%, respectively, in the normal-flow group. The hazard ratio, adjusted for age and stroke risk factors, in the low distal flow status group was 11.55 (95% CI, 1.88-71.00; P = .008). Medical risk factor management at 6-month intervals was similar between patients with low and normal distal flow. Distal flow status remained significantly associated with risk even when controlling for the degree of stenosis and location.Conclusions and relevanceDistal flow status determined using a noninvasive and practical imaging tool is robustly associated with risk for subsequent stroke in patients with symptomatic atherosclerotic VB occlusive disease. Identification of high-risk patients has important implications for future investigation of more aggressive interventional or medical therapies.

Published
2016

31. Abstract 082: Angiographic Features and Treatment Results of Dural Arteriovenous Fistulas Cognitive Impairment

Author

Sanchez, Sebastian A., primary, Wendt, Linder, additional, Ching‐Jen, Chen, additional, Hayakawa, Minako, additional, Samaniego, Edgar, additional, Sheehan, Jason, additional, Kim, Louis, additional, Abecassis, Issac, additional, Levitt, Michael, additional, Meyer, Michael, additional, Guniganti, Ridhima, additional, Pabaney, Akash, additional, Lanzino, Giuseppe, additional, Giordan, Enrico, additional, Brinjikji, Waleed, additional, Bulters, Diederik, additional, Ortega, Santiago, additional, Durnford, Andrew, additional, Zipfel, Gregory, additional, Fox, W, additional, Derdeyn, Colin, additional, Smith, Jessica, additional, Gross, Bradley, additional, Amin‐Hanjani, Sepideh, additional, and Alaraj, Ali, additional

Published
2023
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33. Hemodynamic Features of Symptomatic Vertebrobasilar Disease

Author

Amin-Hanjani, Sepideh, Du, Xinjian, Rose-Finnell, Linda, Pandey, Dilip K, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell SV, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T, Xie, Hui, Flannery, Michael P, Ganin, Hagai, Ruland, Sean, Grysiewicz, Rebecca, Khaja, Aslam, Pedelty, Laura, Testai, Fernando, Ong, Archie, Epstein, Noam, Muqtadar, Hurmina, Watson, Karriem, Mlinarevich, Nada, Hillmann, Maureen, Hirsch, Joy, Dashnaw, Stephen, Meyers, Philip M, Willey, Josh Z, McNeill-Simaan, Edwina, Perez, Veronica, Canaan, Alberto, Paulino-Hernandez, Wayna, Vo, Katie, Foster, Glenn, Ford, Andria, Nassief, Abdullah, Bradley, Abbie, Serna-Northway, Jannie, Kraus, Kristi, Shiwani, Lina, Hantler, Nancy, Alger, Jeffrey, Godinez, Sergio, Saver, Jeffrey L, Ali, Latisha, Kim, Doojin, Tenser, Matthew, Froehler, Michael, Raychev, Radoslav, Song, Sarah, Ovbiagele, Bruce, Abcede, Hermelinda, Adamczyk, Peter, Rao, Neal, Yallapragada, Anil, Modir, Royya, Hinman, Jason, Tansy, Aaron, Calderon-Arnulphi, Mateo, Sheth, Sunil, Noorian, Alireza, Ng, Kwan, Liang, Conrad, Gadhia, Jignesh, Smith, Hannah, Avila, Gilda, Avelar, Johanna, Mikulis, David, Fierstra, Jorn, Hlasny, Eugen, Casaubon, Leanne K, Vergouwen, Mervyn, del Campo, JC Martin, Jaigobin, Cheryl S, Astorga, Cherissa, Kalman, Libby, Kramer, Jeffrey, Vaughan, Susan, Owens, Laura, Kissela, Brett, Turan, Tanya N, Jacobs, Tom P, and Janis, Scott

Subjects
Cardiovascular, Neurosciences, Stroke, Clinical Research, Adult, Aged, Aged, 80 and over, Blood Flow Velocity, Cerebrovascular Circulation, Cohort Studies, Female, Hemodynamics, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Vertebrobasilar Insufficiency, magnetic resonance angiography, magnetic resonance imaging, regional blood flow, stroke, vertebrobasilar ischemia, VERiTAS Study Group, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Neurology & Neurosurgery
Abstract

Background and purposeAtherosclerotic vertebrobasilar disease is an important cause of posterior circulation stroke. To examine the role of hemodynamic compromise, a prospective multicenter study, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS), was conducted. Here, we report clinical features and vessel flow measurements from the study cohort.MethodsPatients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion in vertebral or basilar arteries (BA) were enrolled. Large-vessel flow in the vertebrobasilar territory was assessed using quantitative MRA.ResultsThe cohort (n=72; 44% women) had a mean age of 65.6 years; 72% presented with ischemic stroke. Hypertension (93%) and hyperlipidemia (81%) were the most prevalent vascular risk factors. BA flows correlated negatively with percentage stenosis in the affected vessel and positively to the minimal diameter at the stenosis site (P

Published
2015

36. Dural Arteriovenous Fistulas With Cognitive Impairment: Angiographic Characteristics and Treatment Outcomes

Author

Sanchez, Sebastian, Wendt, Linder, Hayakawa, Minako, Chen, Ching-Jen, Sheehan, Jason P., Kim, Louis J., Abecassis, Isaac Josh, Levitt, Michael R., Meyer, R. Michael, Guniganti, Ridhima, Kansagra, Akash P., Lanzino, Giuseppe, Giordan, Enrico, Brinjikji, Waleed, Bulters, Diederik O., Durnford, Andrew, Fox, W. Christopher, Smith, Jessica, Polifka, Adam J., Gross, Bradley, Amin-Hanjani, Sepideh, Alaraj, Ali, Kwasnicki, Amanda, Starke, Robert M., Chen, Stephanie H., van Dijk, J. Marc C., Potgieser, Adriaan R. E., Satomi, Junichiro, Tada, Yoshiteru, Phelps, Ryan, Abla, Adib, Winkler, Ethan, Du, Rose, Rosalind Lai, Pui Man, Ortega-Gutierrez, Santiago, Zipfel, Gregory J., Derdeyn, Colin, and Samaniego, Edgar A.

Published
2024
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38. Outcome Following Hemorrhage From Cranial Dural Arteriovenous Fistulae: Analysis of the Multicenter International CONDOR Registry

Author

Koch, Matthew J., Stapleton, Christopher J., Guniganti, Ridhima, Lanzino, Giuseppe, Sheehan, Jason, Alaraj, Ali, Bulters, Diederik, Kim, Louis, Fox, W. Christopher, Gross, Bradley A., Hayakawa, Minako, van DijK, J. Marc C., Starke, Robert M., Satomi, Junichiro, Polifka, Adam J., Zipfel, Gregory J., and Amin-Hanjani, Sepideh

Published
2021
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39. Outcomes Associated With Intracranial Aneurysm Treatments Reported as Safe, Effective, or Durable

Author

Volovici, Victor, primary, Verploegh, Iris S., additional, Satoer, Djaina, additional, Vrancken Peeters, Noëlle J. M. C., additional, Sadigh, Yasmin, additional, Vergouwen, Mervyn D. I., additional, Schouten, Joost W., additional, Bruggeman, Gavin, additional, Pisica, Dana, additional, Yildirim, Gizem, additional, Cozar, Ayca, additional, Muller, Femke, additional, Zidaru, Ana-Maria, additional, Gori, Kelsey, additional, Tzourmpaki, Nefeli, additional, Schnell, Esther, additional, Thioub, Mbaye, additional, Kicielinski, Kimberly, additional, van Doormaal, Pieter-Jan, additional, Velinov, Nikolay, additional, Boutarbouch, Mahjouba, additional, Lawton, Michael T., additional, Lanzino, Giuseppe, additional, Amin-Hanjani, Sepideh, additional, Dammers, Ruben, additional, and Meling, Torstein R., additional

Published
2023
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40. O18/172 Dural arteriovenous fistulas with cognitive impairment: angiographic characteristics and treatment outcomes

Author

Sanchez, Sebastian, primary, Wendt, Linder, additional, Hayakawa, Minako, additional, Ortega-Gutierrez, Santiago, additional, Gudino, Andres, additional, Guijarro-Falcon, Katherine, additional, Chen, Chin-Jen, additional, Sheehan, Jason, additional, Kim, Louis, additional, Abecassis, Isaac Josh, additional, Levitt, Michael, additional, Michael Meyer, R, additional, Guniganti, Ridhima, additional, Kansagra, Akash, additional, Lanzino, Giuseppe, additional, Giordan, Enrico, additional, Brinjikji, Waleed, additional, Bulters, Diederik, additional, Durnford, Andrew, additional, Christopher Fox, W, additional, Smith, Jessica, additional, Polifka, Adam, additional, Gross, Bradley, additional, Amin-Hanjani, Sepideh, additional, Alaraj, Ali, additional, Kwasnicki, Amanda, additional, Starke, Robert, additional, Chen, Stephanie, additional, van Dijk, J Marc C, additional, Potsieger, Adriaan, additional, Satomi, Junichiro, additional, Tada, Yoshiteru, additional, Phelps, Ryan, additional, Abla, Adib, additional, Winkler, Ethan, additional, Du, Rose, additional, Rosalind Lai, Pui Man, additional, Zipfel, Gregory, additional, Derdeyn, Colin P, additional, and Samaniego, Edgar, additional

Published
2023
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46. Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research: A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project

Author

Suarez, Jose I., Sheikh, Muniza K., Macdonald, R. Loch, Amin-Hanjani, Sepideh, Brown, Jr., Robert D., de Oliveira Manoel, Airton Leonardo, Derdeyn, Colin P., Etminan, Nima, Keller, Emanuela, Leroux, Peter D., Mayer, Stephan A., Morita, Akio, Rinkel, Gabriel, Rufennacht, Daniel, Stienen, Martin N., Torner, James, Vergouwen, Mervyn D. I., Wong, George K. C., and the Unruptured Intracranial Aneurysms and SAH CDE Project Investigators

Published
2019
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47. Common Data Elements for Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Working Group on Hospital Course and Acute Therapies—Proposal of a Multidisciplinary Research Group

Author

de Oliveira Manoel, Airton Leonardo, van der Jagt, Mathieu, Amin-Hanjani, Sepideh, Bambakidis, Nicholas C., Brophy, Gretchen M., Bulsara, Ketan, Claassen, Jan, Connolly, E. Sander, Hoffer, S. Alan, Hoh, Brian L., Holloway, Robert G., Kelly, Adam G., Mayer, Stephan A., Nakaji, Peter, Rabinstein, Alejandro A., Vajkoczy, Peter, Vergouwen, Mervyn D. I., Woo, Henry, Zipfel, Gregory J., Suarez, Jose I., and the Unruptured Aneurysms and SAH − CDE Project Investigators

Published
2019
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48. The VEBAS score: a practical scoring system for intracranial dural arteriovenous fistula obliteration

Author

Becerril-Gaitan, Andrea, primary, Ding, Dale, additional, Ironside, Natasha, additional, Buell, Thomas J, additional, Kansagra, Akash P, additional, Lanzino, Giuseppe, additional, Brinjikji, Waleed, additional, Kim, Louis, additional, Levitt, Michael R, additional, Abecassis, Isaac Josh, additional, Bulters, Diederik, additional, Durnford, Andrew, additional, Fox, W Christopher, additional, Blackburn, Spiros, additional, Chen, Peng Roc, additional, Polifka, Adam J, additional, Laurent, Dimitri, additional, Gross, Bradley, additional, Hayakawa, Minako, additional, Derdeyn, Colin, additional, Amin-Hanjani, Sepideh, additional, Alaraj, Ali, additional, van Dijk, J Marc C, additional, Potgieser, Adriaan R E, additional, Starke, Robert M, additional, Peterson, Eric C, additional, Satomi, Junichiro, additional, Tada, Yoshiteru, additional, Abla, Adib A, additional, Winkler, Ethan A, additional, Du, Rose, additional, Lai, Pui Man Rosalind, additional, Zipfel, Gregory J, additional, Chen, Ching-Jen, additional, and Sheehan, Jason P, additional

Published
2023
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