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22 results on '"Amimo, Joshua O."'

1. Maternal immunization and vitamin A sufficiency impact sow primary adaptive immunity and passive protection to nursing piglets against porcine epidemic diarrhea virus infection

Author

Amimo, Joshua O., primary, Michael, Husheem, additional, Chepngeno, Juliet, additional, Jung, Kwonil, additional, Raev, Sergei A., additional, Paim, Francine C., additional, Lee, Marcia V., additional, Damtie, Debasu, additional, Vlasova, Anastasia N., additional, and Saif, Linda J., additional

Published
2024
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2. Animal Rotaviruses

Author

Vlasova, Anastasia N., Deol, Pallavi, Sircar, Shubhankar, Ghosh, Souvik, Jakab, Szilvia, Bányai, Krisztián, Dhama, K., Amimo, Joshua O., Saif, Linda J., Malik, Yashpal Singh, Malik, Yashpal Singh, Series Editor, Singh, Rameshwar, Editorial Board Member, Gehlot, A. K., Editorial Board Member, Raj, G. Dhinakar, Editorial Board Member, Bujarbaruah, K. M., Editorial Board Member, Goyal, Sagar M., Editorial Board Member, Tikoo, Suresh K., Editorial Board Member, Singh, Raj Kumar, editor, and Dhama, Kuldeep, editor

Published
2020
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3. Histo-Blood Group Antigen-Producing Bacterial Cocktail Reduces Rotavirus A, B, and C Infection and Disease in Gnotobiotic Piglets.

Author

Raev, Sergei A., Kick, Maryssa K., Chellis, Maria, Amimo, Joshua O., Saif, Linda J., and Vlasova, Anastasia N.

Subjects
ROTAVIRUSES, PIGLETS, PROBIOTICS, BLOOD group antigens, VIRAL shedding, VACCINE development, ROTAVIRUS diseases, INFECTION
Abstract

The suboptimal performance of rotavirus (RV) vaccines in developing countries and in animals necessitates further research on the development of novel therapeutics and control strategies. To initiate infection, RV interacts with cell-surface O-glycans, including histo-blood group antigens (HBGAs). We have previously demonstrated that certain non-pathogenic bacteria express HBGA- like substances (HBGA+) capable of binding RV particles in vitro. We hypothesized that HBGA+ bacteria can bind RV particles in the gut lumen protecting against RV species A (RVA), B (RVB), and C (RVC) infection in vivo. In this study, germ-free piglets were colonized with HBGA+ or HBGA- bacterial cocktail and infected with RVA/RVB/RVC of different genotypes. Diarrhea severity, virus shedding, immunoglobulin A (IgA) Ab titers, and cytokine levels were evaluated. Overall, colonization with HBGA+ bacteria resulted in reduced diarrhea severity and virus shedding compared to the HBGA- bacteria. Consistent with our hypothesis, the reduced severity of RV disease and infection was not associated with significant alterations in immune responses. Additionally, colonization with HBGA+ bacteria conferred beneficial effects irrespective of the piglet HBGA phenotype. These findings are the first experimental evidence that probiotic performance in vivo can be improved by including HBGA+ bacteria, providing decoy epitopes for broader/more consistent protection against diverse RVs. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Increased COVID-19 Mortality and Deficient SARS-CoV-2 Immune Response Are Not Associated with Higher Levels of Endemic Coronavirus Antibodies

Author

Adhikari, Bindu, primary, Oltz, Eugene M., additional, Bednash, Joseph S., additional, Horowitz, Jeffrey C., additional, Amimo, Joshua O., additional, Raev, Sergei A., additional, Fernández, Soledad, additional, Anghelina, Mirela, additional, Liu, Shan-Lu, additional, Rubinstein, Mark P., additional, Jones, Daniel M., additional, Saif, Linda J., additional, and Vlasova, Anastasia N., additional

Published
2023
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7. The Combined Escherichia coli Nissle 1917 and Tryptophan Treatment Modulates Immune and Metabolome Responses to Human Rotavirus Infection in a Human Infant Fecal Microbiota-Transplanted Malnourished Gnotobiotic Pig Model

Author

Michael, Husheem, primary, Srivastava, Vishal, additional, Deblais, Loic, additional, Amimo, Joshua O., additional, Chepngeno, Juliet, additional, Saif, Linda J., additional, Rajashekara, Gireesh, additional, and Vlasova, Anastasia N., additional

Published
2022
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8. Rotavirus A Inoculation and Oral Vitamin A Supplementation of Vitamin A Deficient Pregnant Sows Enhances Maternal Adaptive Immunity and Passive Protection of Piglets against Virulent Rotavirus A

Author

Chepngeno, Juliet, primary, Amimo, Joshua O., additional, Michael, Husheem, additional, Jung, Kwonil, additional, Raev, Sergei, additional, Lee, Marcia V., additional, Damtie, Debasu, additional, Mainga, Alfred O., additional, Vlasova, Anastasia N., additional, and Saif, Linda J., additional

Published
2022
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11. Escherichia coli Nissle 1917 Enhances Efficacy of Oral Attenuated Human Rotavirus Vaccine in a Gnotobiotic Piglet Model

Author

Michael, Husheem, primary, Miyazaki, Ayako, additional, Langel, Stephanie N., additional, Amimo, Joshua O., additional, Kick, Maryssa K., additional, Chepngeno, Juliet, additional, Paim, Francine C., additional, Fischer, David D., additional, Rajashekara, Gireesh, additional, Saif, Linda J., additional, and Vlasova, Anastasia N., additional

Published
2022
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15. Evidence for the presence of African swine fever virus in apparently healthy pigs in South-Kivu Province of the Democratic Republic of Congo

Author

Patrick, Bisimwa N., primary, Machuka, Eunice M., additional, Githae, Dedan, additional, Banswe, Gédéon, additional, Amimo, Joshua O., additional, Ongus, Juliette R., additional, Masembe, Charles, additional, Bishop, Richard P., additional, Steinaa, Lucilla, additional, Djikeng, Appolinaire, additional, and Pelle, Roger, additional

Published
2020
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21. Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies.

Author

Vlasova, Anastasia N., Saif, Linda J., and Amimo, Joshua O.

Subjects
ROTAVIRUSES, ROTAVIRUS vaccines, IMMUNE response, DISEASE prevalence, SWINE
Abstract

Rotaviruses (RVs) are a major cause of acute viral gastroenteritis in young animals and children worldwide. Immunocompetent adults of different species become resistant to clinical disease due to post-infection immunity, immune system maturation and gut physiological changes. Of the 9 RV genogroups (A-I), RV A, B, and C (RVA, RVB, and RVC, respectively) are associated with diarrhea in piglets. Although discovered decades ago, porcine genogroup E RVs (RVE) are uncommon and their pathogenesis is not studied well. The presence of porcine RV H (RVH), a newly defined distinct genogroup, was recently confirmed in diarrheic pigs in Japan, Brazil, and the US. The complex epidemiology, pathogenicity and high genetic diversity of porcine RVAs are widely recognized and well-studied. More recent data show a significant genetic diversity based on the VP7 gene analysis of RVB and C strains in pigs. In this review, we will summarize previous and recent research to provide insights on historic and current prevalence and genetic diversity of porcine RVs in different geographic regions and production systems. We will also provide a brief overview of immune responses to porcine RVs, available control strategies and zoonotic potential of different RV genotypes. An improved understanding of the above parameters may lead to the development of more optimal strategies to manage RV diarrheal disease in swine and humans. [ABSTRACT FROM AUTHOR]

Published
2017
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