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1. Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas

Author

Arrieta, Víctor A., Gould, Andrew, Kim, Kwang-Soo, Habashy, Karl J., Dmello, Crismita, Vázquez-Cervantes, Gustavo I., Palacín-Aliana, Irina, McManus, Graysen, Amidei, Christina, Gomez, Cristal, Dhiantravan, Silpol, Chen, Li, Zhang, Daniel Y., Saganty, Ruth, Cholak, Meghan E., Pandey, Surya, McCord, Matthew, McCortney, Kathleen, Castro, Brandyn, Ward, Rachel, Muzzio, Miguel, Bouchoux, Guillaume, Desseaux, Carole, Canney, Michael, Carpentier, Alexandre, Zhang, Bin, Miska, Jason M., Lesniak, Maciej S., Horbinski, Craig M., Lukas, Rimas V., Stupp, Roger, Lee-Chang, Catalina, and Sonabend, Adam M.

Published
2024
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3. Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.

Author

Dmello, Crismita, Sonabend, Aarón, Arrieta, Victor A, Zhang, Daniel Y, Kanojia, Deepak, Chen, Li, Gould, Andrew, Zhang, Jiangshan, Kang, Seong Jae, Winter, Jan, Horbinski, Craig, Amidei, Christina, Győrffy, Balázs, Cordero, Alex, Chang, Catalina Lee, Castro, Brandyn, Hsu, Patrick, Ahmed, Atique U, Lesniak, Maciej S, Stupp, Roger, and Sonabend, Adam M

Subjects
Neurosciences, Genetics, Breast Cancer, Brain Disorders, Rare Diseases, Cancer, Brain Cancer, Animals, Antineoplastic Agents, Phytogenic, Biomarkers, Pharmacological, Brain Neoplasms, Breast Neoplasms, Calcium-Binding Proteins, Cell Line, Tumor, Drug Resistance, Neoplasm, Endoribonucleases, Female, Glioblastoma, Humans, Membrane Glycoproteins, Mice, Paclitaxel, Prospective Studies, Protein Serine-Threonine Kinases, Receptors, Cytoplasmic and Nuclear, Receptors, Peptide, Xenograft Model Antitumor Assays, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposePaclitaxel (PTX) is one of the most potent and commonly used chemotherapies for breast and pancreatic cancer. Several ongoing clinical trials are investigating means of enhancing delivery of PTX across the blood-brain barrier for glioblastomas. Despite the widespread use of PTX for breast cancer, and the initiative to repurpose this drug for gliomas, there are no predictive biomarkers to inform which patients will likely benefit from this therapy.Experimental designTo identify predictive biomarkers for susceptibility to PTX, we performed a genome-wide CRISPR knockout (KO) screen using human glioma cells. The genes whose KO was most enriched in the CRISPR screen underwent further selection based on their correlation with survival in the breast cancer patient cohorts treated with PTX and not in patients treated with other chemotherapies, a finding that was validated on a second independent patient cohort using progression-free survival.ResultsCombination of CRISPR screen results with outcomes from patients with taxane-treated breast cancer led to the discovery of endoplasmic reticulum (ER) protein SSR3 as a putative predictive biomarker for PTX. SSR3 protein levels showed positive correlation with susceptibility to PTX in breast cancer cells, glioma cells, and in multiple intracranial glioma xenografts models. KO of SSR3 turned the cells resistant to PTX while its overexpression sensitized the cells to PTX. Mechanistically, SSR3 confers susceptibility to PTX through regulation of phosphorylation of ER stress sensor IRE1α.ConclusionsOur hypothesis generating study showed SSR3 as a putative biomarker for susceptibility to PTX, warranting its prospective clinical validation.

Published
2022

4. Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma

Author

Rabin, Erik E., Huang, Jonathan, Kim, Miri, Mozny, Andreas, Lauing, Kristen L., Penco-Campillo, Manon, Zhai, Lijie, Bommi, Prashant, Mi, Xinlei, Power, Erica A., Prabhu, Vikram C., Anderson, Douglas E., Barton, Kevin P., Walunas, Theresa L., Schiltz, Gary E., Amidei, Christina, Sanchez-Gomez, Pilar, Thakkar, Jigisha P., Lukas, Rimas V., and Wainwright, Derek A.

Published
2024
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5. Proceedings of the Survivorship Care in Neuro-Oncology Workshop sponsored by the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT).

Author

Leeper, Heather E, Tonorezos, Emily, Mayer, Deborah, Bakitas, Marie, Chang, Susan, Cooley, Mary E, Hervey-Jumper, Shawn, Miaskowski, Christine, Sherwood, Paula, Tsien, Christina, Wallgren, Kimberly, Willmarth, Nicole, Arons, David, Acquaye, Alvina, King, Amanda L, Penas-Prado, Marta, Vera, Elizabeth, Gilbert, Mark R, Armstrong, Terri S, Arzbaecher, Jean, Dionne-Odom, J Nicholas, Fink, Karen, Hayes, Christi, Leeper, Heather, Lollo, Nicole, Loughan, Ashlee, Oliver, Kathy, Roche, Kayla, Stearn, Sylvia, Timmer, Michael, Amidei, Christina, Blakeley, Jaishri, Cachia, David, Cooke, Laura, Cooley, Mary, Gondi, Vinai, Leach, Danielle, Mendoza, Tito, Morgan, Kendall, Nabors, Burt, Naines, Kristie, Rogers, James, Sharma, Akanksha, Wall, Kathleen, Weathers, Shiao-Pei, Wollet, Alex, Boccia, Maria, Camphausen, Kevin, Christ, Alexa, Figuracion, Karl Cristie, Gilbert, Mark, Komlodi-Pasztor, Edina, Lieberman, Frank, Malkin, Mark, Miller, Hope, Paleologos, Nina, Panzer, Marissa, Stout, Nicole, Wen, Patrick, Beam, Sarah, Boris, Lisa, Fonkem, Ekokobe, Jammula, Varna, Kauss, McKenzie, Kim, Yeonju, Ozer, Byram H, Pan, Edward, Pugh, Stephanie, Strowd, Roy, Wu, Jing, Zaghloul, Kareem, Bell, Susan, Dunbar, Erin M, Haynes, Chas, Haynes, Tuesday, Lesser, Glenn, Maher, Molly, Polskin, Lily, and Pillai, Tina

Subjects
Cancer, Clinical Research, Neurosciences, Management of diseases and conditions, 7.1 Individual care needs, Good Health and Well Being, NCI-CONNECT, patient-centered care, primary central nervous system cancer, survivorship, survivorship care, NCI-CONNECT Survivorship Care in Neuro-Oncology Workshop
Abstract

BackgroundSurvivorship for those living with primary CNS cancers begins at diagnosis, continues throughout a person's life, and includes caregivers. Opportunities and challenges exist to advance survivorship care for those living with primary CNS cancers that necessitate stakeholder involvement.MethodsIn June 2021, NCI-CONNECT convened a two-day virtual workshop about survivorship care in neuro-oncology. Two expert panels provided key recommendations and five working groups considered critical questions to identify strengths, weaknesses, opportunities, and threats to the advancement of survivorship care and developed recommendations and action items.ResultsThe following action items emanated from the workshop: seek endorsement of meeting report from stakeholder organizations; address barriers in access to survivorship care and provider reimbursement; advance survivorship research through NIH and private grant support; develop a survivorship tool kit for providers, people living with primary CNS cancers and their caregivers; provide accessible educational content for neuro-oncology, neurology, and oncology community providers about survivorship care in neuro-oncology; and establish core competencies for survivorship care for neuro-oncology providers to be included in training and standardized exams.ConclusionsAction items aim to address access and reimbursement barriers, expand patient and provider education, develop core competencies, and support survivorship research through funding and other supports.

Published
2022

6. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Author

Arrieta, Víctor A, Chen, Andrew X, Kane, J Robert, Kang, Seong Jae, Kassab, Cynthia, Dmello, Crismita, Zhao, Junfei, Burdett, Kirsten B, Upadhyayula, Pavan S, Lee-Chang, Catalina, Shilati, Joseph, Jaishankar, Dinesh, Chen, Li, Gould, Andrew, Zhang, Daniel, Yuan, Jinzhou, Zhao, Wenting, Ling, Xiaoyang, Burks, Jared K, Laffleur, Brice, Amidei, Christina, Bruce, Jeffrey N, Lukas, Rimas V, Yamaguchi, Jonathan T, Cieremans, David, Rothschild, Gerson, Basu, Uttiya, McCord, Matthew, Brat, Daniel J, Zhang, Hui, Cooper, Lee AD, Zhang, Bin, Sims, Peter, Cloughesy, Tim F, Prins, Robert, Canoll, Peter, Stupp, Roger, Heimberger, Amy B, Horbinski, Craig, Iwamoto, Fabio M, Rabadan, Raul, and Sonabend, Adam M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Brain Cancer, Brain Disorders, Immunotherapy, Genetics, Precision Medicine, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Glioblastoma, Humans, MAP Kinase Signaling System, Neoplasm Recurrence, Local, Phosphorylation, Oncology and carcinogenesis
Abstract

Only a subset of recurrent glioblastoma (rGBM) responds to anti-PD-1 immunotherapy. Previously, we reported enrichment of BRAF/PTPN11 mutations in 30% of rGBM that responded to PD-1 blockade. Given that BRAF and PTPN11 promote MAPK/ERK signaling, we investigated whether activation of this pathway is associated with response to PD-1 inhibitors in rGBM, including patients that do not harbor BRAF/PTPN11 mutations. Here we show that immunohistochemistry for ERK1/2 phosphorylation (p-ERK), a marker of MAPK/ERK pathway activation, is predictive of overall survival following adjuvant PD-1 blockade in two independent rGBM patient cohorts. Single-cell RNA-sequencing and multiplex immunofluorescence analyses revealed that p-ERK was mainly localized in tumor cells and that high-p-ERK GBMs contained tumor-infiltrating myeloid cells and microglia with elevated expression of MHC class II and associated genes. These findings indicate that ERK1/2 activation in rGBM is predictive of response to PD-1 blockade and is associated with a distinct myeloid cell phenotype.

Published
2021

7. Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial

Author

Sonabend, Adam M, Gould, Andrew, Amidei, Christina, Ward, Rachel, Schmidt, Karyn A, Zhang, Daniel Y, Gomez, Cristal, Bebawy, John F, Liu, Benjamin P, Bouchoux, Guillaume, Desseaux, Carole, Helenowski, Irene B, Lukas, Rimas V, Dixit, Karan, Kumthekar, Priya, Arrieta, Víctor A, Lesniak, Maciej S, Carpentier, Alexandre, Zhang, Hui, Muzzio, Miguel, Canney, Michael, and Stupp, Roger

Published
2023
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10. Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated blood–brain barrier opening: A novel combinatorial immunotherapy regimen for gliomas.

Author

Kim, Kwang-Soo, Habashy, Karl, Gould, Andrew, Zhao, Junfei, Najem, Hinda, Amidei, Christina, Saganty, Ruth, Arrieta, Víctor A, Dmello, Crismita, Chen, Li, Zhang, Daniel Y, Castro, Brandyn, Billingham, Leah, Levey, Daniel, Huber, Olivia, Marques, Marilyn, Savitsky, David A, Morin, Benjamin M, Muzzio, Miguel, and Canney, Michael

Published
2024
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12. Blood-Brain Barrier Opening with Ultrasound Augments Doxorubicin and Anti-PD-1 Therapy Efficacy, Intracranial Immune Activation, and Prolongs Survival in Preclinical Glioma Models

Author

Arrieta, Victor Andrés, primary, Gould, Andrew, additional, Kim, Kwang-Soo, additional, Habashy, Karl, additional, Dmello, Crismita, additional, Amidei, Christina, additional, Gómez, Cristal G., additional, Zhang, Daniel, additional, Saganty, Ruth, additional, Chen, Li, additional, Pandey, Surya, additional, Cholak, Meghan E., additional, McCord, Matthew, additional, McCortney, Kathleen, additional, Castro, Brandyn, additional, Ward, Rachel, additional, Muzzio, Miguel, additional, Bouchoux, Guillaume, additional, Desseaux, Carole, additional, Carpentier, Alexandre C., additional, Zhang, Bin, additional, Miska, Jason, additional, Horbinski, Craig, additional, Lukas, Rimas Vincas, additional, Stupp, Roger, additional, Chang, Catalina Lee, additional, and Sonabend, Adam M., additional

Published
2024
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13. Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial

Author

Fares, Jawad, Ahmed, Atique U, Ulasov, Ilya V, Sonabend, Adam M, Miska, Jason, Lee-Chang, Catalina, Balyasnikova, Irina V, Chandler, James P, Portnow, Jana, Tate, Matthew C, Kumthekar, Priya, Lukas, Rimas V, Grimm, Sean A, Adams, Ann K, Hébert, Charles D, Strong, Theresa V, Amidei, Christina, Arrieta, Victor A, Zannikou, Markella, Horbinski, Craig, Zhang, Hui, Burdett, Kirsten Bell, Curiel, David T, Sachdev, Sean, Aboody, Karen S, Stupp, Roger, and Lesniak, Maciej S

Published
2021
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15. BIOM-15. CIRCULATING EXOSOMES CORRELATE WITH RADIOGRAPHIC PROGRESSION IN GLIOBLASTOMA PATIENTS AFTER ULTRASOUND-BASED OPENING OF THE BLOOD-BRAIN BARRIER

Author

Youngblood, Mark W, primary, Kumari, Abha, additional, Gould, Andrew, additional, Kang, Yoon-Tae, additional, Chen, Li, additional, Habashy, Karl, additional, Amidei, Christina, additional, Ward, Rachel, additional, Gomez, Cristal, additional, Bouchoux, Guillaume, additional, Canney, Michael, additional, Stupp, Roger, additional, Nagrath, Sunitha, additional, and Sonabend, Adam, additional

Published
2023
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16. IMMU-21. LOW-INTENSITY PULSED ULTRASOUND PROMOTES THE PRESENTATION OF BRAIN-DERIVED ANTIGENS THROUGH ENHANCED TRAFFICKING OF ANTIGEN-PRESENTING CELLS FROM THE BRAIN INTO THE PERIPHERY

Author

Gallus, Marco, primary, Arrieta, Victor, additional, Saijo, Atsuro, additional, Haegelin, Jeffrey, additional, Chuntova, Pavlina, additional, Yamamichi, Akane, additional, Chen, Li, additional, Habashy, Karl, additional, Gould, Andrew, additional, Amidei, Christina, additional, Chang, Catalina Lee, additional, Stupp, Roger, additional, Canney, Michael, additional, Sonabend, Adam, additional, and Okada, Hideho, additional

Published
2023
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17. EXTH-24. FC-ENHANCED ANTI-CTLA-4 IMMUNE CHECKPOINT BLOCKADE AND ITS COMBINATION WITH ANTI-PD-1 WITH CONCOMITANT DOXORUBICIN AND ULTRASOUND-MEDIATED BBB OPENING: A NOVEL IMMUNOTHERAPY FOR GLIOBLASTOMA

Author

Kim, Kwang-Soo, primary, Habashy, Karl, additional, Gould, Andrew, additional, Najem, Hinda, additional, Zhao, Junfei, additional, Amidei, Christina, additional, Saganty, Ruth, additional, Arrieta, Victor, additional, Dmello, Crismita, additional, Chen, Li, additional, Zhang, Daniel, additional, Castro, Brandyn, additional, Billingham, Leah, additional, Levey, Daniel, additional, Morin, Benjamin, additional, Muzzio, Miguel, additional, Canney, Michael, additional, McCortney, Katy, additional, Horbinski, Craig, additional, Zhang, Peng, additional, Miska, Jason, additional, Rabadan, Raul, additional, Heimberger, Amy, additional, Stupp, Roger, additional, Chand, Dhan, additional, Lee-Chang, Catalina, additional, and Sonabend, Adam, additional

Published
2023
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18. Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Author

Arrieta, Víctor A., Chen, Andrew X., Kane, J. Robert, Kang, Seong Jae, Kassab, Cynthia, Dmello, Crismita, Zhao, Junfei, Burdett, Kirsten B., Upadhyayula, Pavan S., Lee-Chang, Catalina, Shilati, Joseph, Jaishankar, Dinesh, Chen, Li, Gould, Andrew, Zhang, Daniel, Yuan, Jinzhou, Zhao, Wenting, Ling, Xiaoyang, Burks, Jared K., Laffleur, Brice, Amidei, Christina, Bruce, Jeffrey N., Lukas, Rimas V., Yamaguchi, Jonathan T., Cieremans, David, Rothschild, Gerson, Basu, Uttiya, McCord, Matthew, Brat, Daniel J., Zhang, Hui, Cooper, Lee A. D., Zhang, Bin, Sims, Peter, Cloughesy, Tim F., Prins, Robert, Canoll, Peter, Stupp, Roger, Heimberger, Amy B., Horbinski, Craig, Iwamoto, Fabio M., Rabadan, Raul, and Sonabend, Adam M.

Published
2022
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19. Motivational Interviewing: Improving Confidence With Self-care Management in Postoperative Thoracolumbar Spine Patients

Author

Scheffel, Kimberly, Amidei, Christina, and Fitzgerald, Kathleen A.

Subjects
Self care (Health) -- Methods -- Psychological aspects, Spinal surgery -- Patient outcomes, Confidence -- Health aspects, Spinal diseases -- Care and treatment -- Patient outcomes, Motivational interviewing -- Usage -- Health aspects, Health promotion -- Methods -- Psychological aspects, Health care industry
Abstract

Patients undergoing thoracic or lumbar spine surgery often lack confidence with self-care management of symptoms contributing to disability, suchas pain, lack of sleep, depression, and immobility. The purpose of this pilot study was to examine whether a targeted motivational interview, focused on evidence-based recommendations to manage postoperative symptoms related to thoracolumbar spine surgery, would improve patient confidence with self-care management of their symptom-related disability. A quasiexperimental, 1-group, pretest-posttest design was used on a convenience sample of 15 adult surgical spine patients at a large university spine center. Level of disability was measured using the Oswestry Disability Index (ODI). Confidence with self-care management of symptom-related disability was measured using the Health Confidence Index (HCI). Paired samples f tests were completed on participants' preintervention and postintervention scores on the HCI and ODI and on each of the 10 items that the ODI questionnaire addresses. The results of the paired samples f test on participants' HCI scores showed a statistically significant improvement in participants' confidence with self-care management of symptom-related disability from pretest (mean [SD], 6.73 [2.12]) to posttest (mean [SD], 8.73 [1.43]), conditions: [t.sub.14] = -3.80, P= .002. Motivational interviewing is a beneficial intervention for health professionals to incorporate into practice to encourage the implementation of various health promoting behaviors that improve confidence with self-care management of symptoms in postoperative thoracolumbar spine patients. Keywords: health confidence, health promotion, motivational interviewing, self-care management, spine disorders, Adult spine disorders related to degenerative disc disease, osteoarthritis, and osteoporosis are on the rise because of the increasing aging population in the United States. (1,2) Osteopenia, sarcopenia, and spinal [...]

Published
2019
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20. 381 Repeated Opening of the Blood-Brain Barrier With the Skull-implantable SonoCloud-9 (SC9) Device: Phase 1 Trial of Nab-Paclitaxel and SC9 in Recurrent Glioblastoma

Author

Sonabend, Adam M., primary, Gould, Andrew, additional, Luan, Yu, additional, Hou, Ye, additional, Chen, Le, additional, Kobayashi, Mikoto, additional, Castro, Brandyn, additional, Zhang, Daniel, additional, Korobova, Farida, additional, Amidei, Christina, additional, Youngblood, Mark William, additional, Bebawy, John Patrick, additional, Liu, Benjamin P., additional, Horbinski, Craig, additional, Desseaux, Carole, additional, Helenowski, Irene, additional, Zhang, Hui, additional, Muzzio, Miguel, additional, Yue, Feng, additional, Caney, Michael, additional, and Stupp, Roger, additional

Published
2023
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21. Data from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma

Author

Dmello, Crismita, primary, Sonabend, Aarón, primary, Arrieta, Victor A., primary, Zhang, Daniel Y., primary, Kanojia, Deepak, primary, Chen, Li, primary, Gould, Andrew, primary, Zhang, Jiangshan, primary, Kang, Seong Jae, primary, Winter, Jan, primary, Horbinski, Craig, primary, Amidei, Christina, primary, Győrffy, Balázs, primary, Cordero, Alex, primary, Chang, Catalina Lee, primary, Castro, Brandyn, primary, Hsu, Patrick, primary, Ahmed, Atique U., primary, Lesniak, Maciej S., primary, Stupp, Roger, primary, and Sonabend, Adam M., primary

Published
2023
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22. Supplementary Figure from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma

Author

Dmello, Crismita, primary, Sonabend, Aarón, primary, Arrieta, Victor A., primary, Zhang, Daniel Y., primary, Kanojia, Deepak, primary, Chen, Li, primary, Gould, Andrew, primary, Zhang, Jiangshan, primary, Kang, Seong Jae, primary, Winter, Jan, primary, Horbinski, Craig, primary, Amidei, Christina, primary, Győrffy, Balázs, primary, Cordero, Alex, primary, Chang, Catalina Lee, primary, Castro, Brandyn, primary, Hsu, Patrick, primary, Ahmed, Atique U., primary, Lesniak, Maciej S., primary, Stupp, Roger, primary, and Sonabend, Adam M., primary

Published
2023
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23. Supplementary Table from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma

Author

Dmello, Crismita, primary, Sonabend, Aarón, primary, Arrieta, Victor A., primary, Zhang, Daniel Y., primary, Kanojia, Deepak, primary, Chen, Li, primary, Gould, Andrew, primary, Zhang, Jiangshan, primary, Kang, Seong Jae, primary, Winter, Jan, primary, Horbinski, Craig, primary, Amidei, Christina, primary, Győrffy, Balázs, primary, Cordero, Alex, primary, Chang, Catalina Lee, primary, Castro, Brandyn, primary, Hsu, Patrick, primary, Ahmed, Atique U., primary, Lesniak, Maciej S., primary, Stupp, Roger, primary, and Sonabend, Adam M., primary

Published
2023
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24. Supplementary Data from Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma

Author

Dmello, Crismita, primary, Sonabend, Aarón, primary, Arrieta, Victor A., primary, Zhang, Daniel Y., primary, Kanojia, Deepak, primary, Chen, Li, primary, Gould, Andrew, primary, Zhang, Jiangshan, primary, Kang, Seong Jae, primary, Winter, Jan, primary, Horbinski, Craig, primary, Amidei, Christina, primary, Győrffy, Balázs, primary, Cordero, Alex, primary, Chang, Catalina Lee, primary, Castro, Brandyn, primary, Hsu, Patrick, primary, Ahmed, Atique U., primary, Lesniak, Maciej S., primary, Stupp, Roger, primary, and Sonabend, Adam M., primary

Published
2023
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26. Mutant IDH1 and thrombosis in gliomas

Author

Unruh, Dusten, Schwarze, Steven R., Khoury, Laith, Thomas, Cheddhi, Wu, Meijing, Chen, Li, Chen, Rui, Liu, Yinxing, Schwartz, Margaret A., Amidei, Christina, Kumthekar, Priya, Benjamin, Carolina G., Song, Kristine, Dawson, Caleb, Rispoli, Joanne M., Fatterpekar, Girish, Golfinos, John G., Kondziolka, Douglas, Karajannis, Matthias, Pacione, Donato, Zagzag, David, McIntyre, Thomas, Snuderl, Matija, and Horbinski, Craig

Published
2016
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27. Determining venous thromboembolism risk in patients with adult-type diffuse glioma

Author

Burdett, Kirsten Bell, primary, Unruh, Dusten, additional, Drumm, Michael, additional, Steffens, Alicia, additional, Lamano, Jonathan Balquiedra, additional, Judkins, Jonathan, additional, Schwartz, Margaret, additional, Javier, Rodrigo, additional, Amidei, Christina, additional, Lipp, Eric Scott, additional, Peters, Katherine B., additional, Lai, Albert, additional, Eldred, Blaine S.C., additional, Heimberger, Amy B., additional, McCortney, Kathleen, additional, Scholtens, Denise M., additional, and Horbinski, Craig, additional

Published
2022
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29. EPID-08. AGE-STRATIFIED SURVIVAL ANALYSES OF PHARMACOLOGICAL TREATMENTS IN PATIENTS WITH GLIOBLASTOMA

Author

Rabin, Erik, primary, Mi, Xinlei, additional, Huang, Jonathan, additional, Kim, Miri, additional, Mozny, Andreas, additional, Amidei, Christina, additional, Sieg, Erica, additional, Bell, April, additional, Zhai, Lijie, additional, Bommi, Prashant, additional, Lauing, Kristen, additional, Lukas, Rimas, additional, and Wainwright, Derek, additional

Published
2022
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30. QOL-06. PREDICTING VENOUS THROMBOEMBOLISM IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMAS

Author

Burdett, Kirsten B, primary, Unruh, Dusten, additional, Drumm, Michael, additional, Lamano, Jonathan, additional, Schwartz, Margaret, additional, Chandler, James, additional, Javier, Rodrigo, additional, Steffens, Alicia, additional, Amidei, Christina, additional, Lipp, Eric S, additional, Peters, Katherine B, additional, Lai, Albert, additional, Eldred, Blaine, additional, McCortney, Kathleen, additional, Heimberger, Amy, additional, Scholtens, Denise, additional, and Horbinski, Craig, additional

Published
2022
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31. CTNI-37. REPEATED OPENING OF THE BLOOD-BRAIN BARRIER WITH THE SKULL-IMPLANTABLE SONOCLOUD-9 (SC9) DEVICE: PHASE 1 TRIAL OF NAB-PACLITAXEL AND SC9 IN RECURRENT GLIOBLASTOMA

Author

Sonabend, Adam M, primary, Gould, Andrew, additional, Luan, Yu, additional, Hou, Ye, additional, Kobayashi, Mikoto A, additional, Castro, Brandyn, additional, Zhang, Daniel Y, additional, Chen, Li, additional, Korobova, Farida, additional, Amidei, Christina, additional, Youngblood, Mark, additional, Bebawy, John Patrick F, additional, Liu, Benjamin, additional, Horbinski, Craig, additional, Desseaux, Carole, additional, Helenowski, Irene B, additional, Zhang, Hui, additional, Muzzio, Miguel, additional, Yue, Feng, additional, Canney, Michael, additional, and Stupp, Roger, additional

Published
2022
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33. Repeated opening of the blood-brain barrier with the skull-implantable SonoCloud-9 (SC9) device: Phase 1 trial of nab-paclitaxel and SC9 in recurrent glioblastoma.

Author

Sonabend, Adam M., primary, Gould, Andrew, additional, Luan, Yu, additional, Hou, Ye, additional, Chen, Li, additional, Kobayashi, Mikoto A., additional, Castro, Brandyn A., additional, Zhang, Daniel Y., additional, Korobova, Farida V., additional, Amidei, Christina, additional, Bebawy, John F., additional, Liu, Benjamin P, additional, Horbinski, Craig M., additional, Desseaux, Carole, additional, Helenowski, Irene B., additional, Zhang, Hui, additional, Muzzio, Miguel M, additional, Yue, Feng, additional, Canney, Michael, additional, and Stupp, Roger, additional

Published
2022
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37. A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer

Author

Rabin, Erik E., primary, Kim, Miri, additional, Mozny, Andreas, additional, Cardoza, Krislyn, additional, Bell, April C., additional, Zhai, Lijie, additional, Bommi, Prashant, additional, Lauing, Kristen L., additional, King, Amanda L., additional, Armstrong, Terri S., additional, Walunas, Theresa L., additional, Fang, Deyu, additional, Roy, Ishan, additional, Peipert, John D., additional, Sieg, Erica, additional, Mi, Xinlei, additional, Amidei, Christina, additional, Lukas, Rimas V., additional, and Wainwright, Derek A., additional

Published
2022
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38. Large-field skull-implantable ultrasound opens the blood-brain-barrier leading to ultrastructural and transcriptional alterations in endothelium and enhanced drug penetration to the human brain: phase 1 trial using albumin-bound paclitaxel in recurrent glioblastoma

Author

Sonabend, Adam M, primary, Gould, Andrew, additional, Luan, Yu, additional, Hou, Ye, additional, Dessaux, Carole, additional, Kobayashi, Mikoto, additional, Castro, Brandyn, additional, Zhang, Daniel, additional, Korobova, Farida, additional, Amidei, Christina, additional, Youngblood, Mark, additional, Bebawy, John Patrick, additional, Lu, Benjamin, additional, Horbinski, Craig, additional, Helenowski, Irene, additional, Zhang, Hui, additional, Muzzio, Miguel, additional, Yue, Feng, additional, Canney, Mike, additional, and Stupp, Roger, additional

Published
2022
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39. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial

Author

Chiocca, E Antonio, primary, Gelb, Arnold B, additional, Chen, Clark C, additional, Rao, Ganesh, additional, Reardon, David A, additional, Wen, Patrick Y, additional, Bi, Wenya Linda, additional, Peruzzi, Pierpaolo, additional, Amidei, Christina, additional, Triggs, Dan, additional, Seften, Leah, additional, Park, Grace, additional, Grant, James, additional, Truman, Kyla, additional, Buck, Jill Y, additional, Hadar, Nira, additional, Demars, Nathan, additional, Miao, John, additional, Estupinan, Taylor, additional, Loewy, John, additional, Chadha, Kamal, additional, Tringali, Joseph, additional, Cooper, Laurence, additional, and Lukas, Rimas V, additional

Published
2021
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40. BIOM-31. ERK1/2 PHOSPHORYLATION PREDICTS SURVIVAL FOLLOWING ANTI-PD-1 IMMUNOTHERAPY IN RECURRENT GLIOBLASTOMA

Author

Arrieta, Víctor, primary, Chen, Andrew X, additional, Kane, J Robert, additional, Kang, Seong Jae, additional, Kassab, Cynthia, additional, Dmello, Crismita, additional, Zhao, Junfei, additional, Burdett, Kirsten, additional, Upadhyayula, Pavan, additional, Chang, Catalina, additional, Shilati, Joseph, additional, Jaishankar, Dinesh, additional, Chen, Li, additional, Gould, Andrew, additional, Zhang, Daniel, additional, Yuan, Jinzhou, additional, Zhao, Wenting, additional, Ling, Xiaoyang, additional, Burks, Jared K, additional, Laffleur, Brice, additional, Amidei, Christina, additional, Bruce, Jeffrey N, additional, Lukas, Rimas V, additional, Yamaguchi, Jonathan T, additional, Cieremans, David, additional, Rothschild, Gerson, additional, Basu, Uttiya, additional, McCord, Matthew, additional, Brat, Daniel, additional, Zhang, Hui, additional, Cooper, Lee A D, additional, Zhang, Bin, additional, Sims, Peter, additional, Cloughesy, Timothy, additional, Prins, Robert, additional, Canoll, Peter, additional, Stupp, Roger, additional, Heimberger, Amy B, additional, Horbinski, Craig, additional, Iwamoto, Fabio, additional, Rabadan, Raul, additional, and Sonabend, Adam M, additional

Published
2021
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42. CTIM-20. FINAL RESULTS OF CONTROLLED IL-12 MONOTHERAPY AND IN COMBINATION WITH PD-1 INHIBITOR IN ADULT SUBJECTS WITH RECURRENT GLIOBLASTOMA

Author

Lukas, Rimas, primary, Oberheim-Bush, Nancy Ann, additional, Cavaliere, Robert, additional, Landolfi, Joseph, additional, Yu, John S, additional, Chen, Clark, additional, Cordova, Christine, additional, Amidei, Christina, additional, Buck, Jill Y, additional, Hadar, Nira, additional, Demars, Nate, additional, Miao, John, additional, Loewy, John, additional, Estupinan, Taylor, additional, Chadha, Kamal, additional, Cooper, Laurence J N, additional, and Chiocca, E Antonio, additional

Published
2021
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44. Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial.

Author

Chiocca, E Antonio, Gelb, Arnold B, Chen, Clark C, Rao, Ganesh, Reardon, David A, Wen, Patrick Y, Bi, Wenya Linda, Peruzzi, Pierpaolo, Amidei, Christina, Triggs, Dan, Seften, Leah, Park, Grace, Grant, James, Truman, Kyla, Buck, Jill Y, Hadar, Nira, Demars, Nathan, Miao, John, Estupinan, Taylor, and Loewy, John

Published
2022
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45. Disappearance of MMR-deficient subclones after controlled IL-12 and PD-1 inhibition in a glioma patient

Author

McCord, Matthew, primary, Lukas, Rimas V, additional, Amidei, Christina, additional, Demars, Nathan, additional, Gelb, Arnold, additional, Buck, Jill, additional, Sachdev, Sean, additional, Feldman, Alexander, additional, Tate, Matthew, additional, Dixit, Karan, additional, Brat, Daniel J, additional, Jennings, Lawrence, additional, and Horbinski, Craig, additional

Published
2021
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46. The brain tumor not-for-profit and charity experience of COVID-19: reacting and adjusting to an unprecedented global pandemic in the 21st century

Author

Amidei, Christina, primary, Arzbaecher, Jean, additional, Maher, Mary Ellen, additional, Mungoshi, Christine, additional, Cashman, Rosemary, additional, Farrimond, Stuart, additional, Kruchko, Carol, additional, Tse, Chris, additional, Daniels, Maureen, additional, Lamb, Sharon, additional, Granero, Anita, additional, Lovely, Mary, additional, Baker, Jenifer, additional, Payne, Sally, additional, and Oliver, Kathy, additional

Published
2020
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49. CTIM-05. COMBINATION OF CONTROLLED INTERLEUKIN-12 GENE THERAPY WITH IMMUNE CHECKPOINT BLOCKADE IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS OF A MULTI-INSTITUTIONAL, OPEN LABEL PHASE 1 TRIAL

Author

Antonio Chiocca, E, primary, Lukas, Rimas, additional, Chen, Clark, additional, Rao, Ganesh, additional, Amidei, Christina, additional, Buck, Jill, additional, Hadar, Nira, additional, Demars, Nathan, additional, Miao, John, additional, Estupinan, Taylor, additional, Loewy, John, additional, Wang, Yunxia, additional, Gelb, Arnold, additional, and Cooper, Laurence, additional

Published
2020
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50. COVD-11. THE BRAIN TUMOR AND NOT FOR PROFIT AND CHARITY EXPERIENCE OF COVID 19: REACTING AND ADJUSTING TO AN UNPRECEDENTED GLOBAL PANDEMIC IN THE 21ST CENTURY

Author

Ellen Maher, Mary, primary, Amidei, Christina, additional, Arzbaecher, Jean, additional, Oliver, Kathy, additional, Mungoshi, Christine, additional, Cashman, Rosemary, additional, Farrimond, Stuart, additional, Kruchko, Carol, additional, Granero, Anita, additional, Tse, Chris, additional, Daniels, Maureen, additional, Lovely, Mary, additional, Payne, Sally, additional, Lamb, Sharon, additional, and Baker, Jenifer, additional

Published
2020
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