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Your search keyword '"Amengual, Josep"' showing total 14 results
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14 results on '"Amengual, Josep"'

2. The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche.

Author

Gonzalez‐Sanchez, Ester, Vaquero, Javier, Caballero‐Diaz, Daniel, Grzelak, Jan, Fusté, Noel P, Bertran, Esther, Amengual, Josep, Garcia‐Saez, Juan, Martín‐Mur, Beatriz, Gut, Marta, Esteve‐Codina, Anna, Alay, Ania, Coulouarn, Cedric, Calero‐Perez, Silvia, Valdecantos, Pilar, Valverde, Angela M, Sánchez, Aránzazu, Herrera, Blanca, and Fabregat, Isabel

Subjects
MET receptor, EPIDERMAL growth factor receptors, EXTRACELLULAR matrix proteins, HEPATIC fibrosis, LIVER
Abstract

Liver fibrosis is the consequence of chronic liver injury in the presence of an inflammatory component. Although the main executors of this activation are known, the mechanisms that lead to the inflammatory process that mediates the production of pro‐fibrotic factors are not well characterized. Epidermal growth factor receptor (EGFR) signaling in hepatocytes is essential for the regenerative processes of the liver; however, its potential role in regulating the fibrotic niche is not yet clear. Our group generated a mouse model that expresses an inactive truncated form of the EGFR specifically in hepatocytes (ΔEGFR mice). Here, we have analyzed the response of WT and ΔEGFR mice to chronic treatment with carbon tetrachloride (CCl4), which induces a pro‐inflammatory and fibrotic process in the liver. The results indicated that the hallmarks of liver fibrosis were attenuated in CCl4‐treated ΔEGFR mice when compared with CCl4‐treated WT mice, coinciding with a faster resolution of the fibrotic process and ameliorated damage. The absence of EGFR activity in hepatocytes induced changes in the pattern of immune cells in the liver, with a notable increase in the population of M2 macrophages, more related to fibrosis resolution, as well as in the population of lymphocytes related to eradication of the damage. Transcriptome analysis of hepatocytes, and secretome studies of extracellular media from in vitro experiments, allowed us to elucidate the specific molecular mechanisms regulated by EGFR that mediate hepatocyte production of both pro‐fibrotic and pro‐inflammatory mediators; these have consequences for the deposition of extracellular matrix proteins, as well as for the immune microenvironment. Overall, our study uncovered novel mechanistic insights regarding EGFR kinase‐dependent actions in hepatocytes that reveal its key role in chronic liver damage. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Towards global data products of Essential Biodiversity Variables on species traits

Author

Kissling, W. Daniel, Walls, Ramona, Bowser, Anne, Jones, Matthew O., Kattge, Jens, Agosti, Donat, Amengual, Josep, Basset, Alberto, van Bodegom, Peter M., Cornelissen, Johannes H. C., Denny, Ellen G., Deudero, Salud, Egloff, Willi, Elmendorf, Sarah C., Alonso García, Enrique, Jones, Katherine D., Jones, Owen R., Lavorel, Sandra, Lear, Dan, Navarro, Laetitia M., Pawar, Samraat, Pirzl, Rebecca, Rüger, Nadja, Sal, Sofia, Salguero-Gómez, Roberto, Schigel, Dmitry, Schulz, Katja-Sabine, Skidmore, Andrew, and Guralnick, Robert P.

Published
2018
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4. Role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway on the cellular interactome within the liver fibrotic niche

Author

Gonzalez-Sanchez, Ester, primary, Vaquero, Javier, additional, Caballero-Díaz, Daniel, additional, Grzelak, Jan, additional, Bertran, Esther, additional, Amengual, Josep, additional, García-Sáez, Juan, additional, Valdecantos, Pilar, additional, Valverde, Angela Martinez, additional, Sanchez, Aranzazu, additional, Herrera, Blanca, additional, and Fabregat, Isabel, additional

Published
2023
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5. Terms of reference for the mediterranean tuna habitat observatory initiative

Author

Álvarez-Berastegui, Diego, Tugores, María Pilar, Juzà, Melanie, Hernández Carrasco, Ismael, Sanz-Martín, Marina, Reglero, Patricia, Macías, Diego, Balbín, Rosa, Lázaro, G., Antoine, L., Mavruk, S., Cuttitta, A., Russo, S., Patti, Bernardo, Torri, M., Reyes, Emma, Moure, B., Orfila, Alejandro, Gordoa, Ana, Abascal, C., Laiz, Irene, Amengual, Josep, Hidalgo, Manuel, Cabanellas-Reboredo, Miguel, Báez, José Carlos, Juan Jordá, M. J., Kell, L., Hanke, A., Die, D., Tintoré, Joaquín, Cardin, Vanessa, Álvarez-Berastegui, Diego, Tugores, María Pilar, Juzà, Melanie, Hernández Carrasco, Ismael, Sanz-Martín, Marina, Reglero, Patricia, Macías, Diego, Balbín, Rosa, Lázaro, G., Antoine, L., Mavruk, S., Cuttitta, A., Russo, S., Patti, Bernardo, Torri, M., Reyes, Emma, Moure, B., Orfila, Alejandro, Gordoa, Ana, Abascal, C., Laiz, Irene, Amengual, Josep, Hidalgo, Manuel, Cabanellas-Reboredo, Miguel, Báez, José Carlos, Juan Jordá, M. J., Kell, L., Hanke, A., Die, D., Tintoré, Joaquín, and Cardin, Vanessa

Abstract

[EN] We present the Terms of Reference for a case study on a Mediterranean eco-region focusing on the environmental component of the Ecosystem Report Card. The objective of this case study is to describe and monitor the variability of environmental processes in the Mediterranean Sea that affect the ecology of large pelagic fishes, with a particular attention on tunas, and the possible role of climate change on this variability. Here we define the objectives and activities of the initiative, the participant roles, primary indicators and the methodological approach, [FR] Ce document présente les termes de référence d’une étude de cas sur une écorégion méditerranéenne consacrée à la composante environnementale de la fiche informative sur les écosystèmes. L'objectif de cette étude de cas est de décrire et de suivre la variabilité des processus environnementaux en mer Méditerranée qui affectent l'écologie des grands poissons pélagiques, en accordant une attention particulière aux thonidés, et de déterminer le rôle possible du changement climatique sur cette variabilité. Nous définissons ici les objectifs et les activités de l'initiative, les rôles des participants, les indicateurs primaires et l'approche méthodologique., [ES] En el documento se presentan los términos de referencia para un estudio de caso sobre una ecorregión mediterránea centrado en el componente medioambiental de la ficha informativa sobre ecosistemas. El objetivo de este estudio de caso es describir y hacer un seguimiento de la variabilidad de los procesos medioambientales en el mar Mediterráneo que afectan a la ecología de los grandes peces pelágicos, con especial atención a los túnidos, y el posible papel del cambio climático en esta variabilidad. A continuación, se definen los objetivos y actividades de la iniciativa, las funciones de los participantes, los indicadores principales y el enfoque metodológico.

Published
2023

6. Senescence, hand in hand with hepatic iron overload during the progression of NAFLD

Author

Bravo, Miren, primary, Simón, Jorge, additional, Goikoetxea, Naroa, additional, Lachiondo-Ortega, Sofia, additional, Egia-Mendikute, Leire, additional, Maus, Mate, additional, Pelusi, Serena, additional, Amengual, Josep, additional, Gonzalez-Sanchez, Ester, additional, Vaquero, Javier, additional, Nogueiras, Ruben, additional, Palazón, Asís, additional, Valenti, Luca, additional, Fabregat, Isabel, additional, Serrano, Manuel, additional, and Martínez-Chantar, María Luz, additional

Published
2022
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9. Dual NOX4/NOX1 inhibition by setanaxib halts cholangiocarcinoma progression by impairing cancer associated fibroblast activation.

Author

Amengual, Josep, Gonzalez-Sanchez, Ester, Fuste, Noel P., Pons, Gabriel, Sererols-Viñas, Laura, Alay, Ania, Hijazo-Pechero, Sara, Martín-Mur, Beatriz, Esteve-Codina, Anna, Ferrer, Joana, Gores, Gregory J., Ilyas, Sumera I., Calvisi, Diego, Aoudjehane, Lynda, Fouassier, Laura, Coulouarn, Cedric, Affo, Silvia, Fabregat, Isabel, and Vaquero, Javier

Subjects
*CHOLANGIOCARCINOMA, *CANCER invasiveness
Published
2024
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13. Towards improved understanding of the status, ecology and conservation seagrass (Posidonia oceanica L. Delile) meadows in the Balearic Islands

Author

Duarte, Carlos M., Álvarez, Elvira, Amengual, Josep, Barrón, Cristina, Basterretxea, Gotzon, Calleja, Maria Ll., Deudero Company, María de la Salud, Díaz-Almela, Elena, Grau, Antoni Maria, Massutí, Catalina, García, Micaela, Morales-Nin, Beatriz, Moranta, Joan, Marbà, Núria, Oro, Daniel, Planas, Miguel, Rosselló-Mora, Ramón, Sintes, Tomàs, Terrados, Jorge, and Tintoré, Joaquín

Subjects
Grassland ecology, education, Natural History
Abstract

not available

Published
2003

14. Cap a una millor comprensió de l'estat, ecologia i conservació de les praderies d'angiospermes marines (Posidonia oceanica L. Delile) de les Illes Balears

Author

Duarte, Carlos M., Álvarez, Elvira, Amengual, Josep, Barrón, Cristina, Basterretxea, Gotzon, Calleja, María, Deudero, Salud, Díaz-Almela, Elena, Grau, Antoni, Massutí, Catalina, García, Micaela, Morales, Beatriz, Moranta, Joan, Marbà, Núria, Oro, Daniel, Planas, Miquel, Rosselló-Mora, Ramón, Sintes, Tomás, Terrados, Jorge, Tintoré, Joaquín, Duarte, Carlos M., Álvarez, Elvira, Amengual, Josep, Barrón, Cristina, Basterretxea, Gotzon, Calleja, María, Deudero, Salud, Díaz-Almela, Elena, Grau, Antoni, Massutí, Catalina, García, Micaela, Morales, Beatriz, Moranta, Joan, Marbà, Núria, Oro, Daniel, Planas, Miquel, Rosselló-Mora, Ramón, Sintes, Tomás, Terrados, Jorge, and Tintoré, Joaquín

Abstract

not available

Published
2003

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