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6 results on '"Amel Ginawi"'

1. The Use of Bone Density Scan in Monitoring Treatment Response in Patients Diagnosed with Osteoporosis: A Retrospective Cohort Study

Author

Mohammed O. Ibrahim, Ahmad Kolleri, and Amel Ginawi

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Osteoporosis is characterized as a metabolic bone disease defined by low bone mineral density (BMD) and bone tissue degeneration, particularly a reduction in the number of trabeculae and a drop in cortical bone thickness, and a rise in porosity, which is mainly due to an imbalance between bone resorption and formation. As a result, it increases bone fragility, and the susceptibility to fracture increases, especially among the elderly. The objective is to assess the effectiveness of dual-energy X-ray absorptiometry (DXA) scan in monitoring the response to osteoporosis treatment and compare the scan’s response to different osteoporosis treatments. This retrospective cohort study included 51 adults selected from 300 patients diagnosed with osteoporosis based on World Health Organization (WHO) diagnostic criteria of a T-score of -2.5. Data were acquired from the electronic medical records between 2016 and 2019 from a private hospital in Dubai, United Arab Emirates (UAE). The study included sociodemographic characteristics, biomedical parameters, comorbidities, history of fracture, medications, laboratory, and DXA scan results. Ninety-four percent of the patients were females; the mean (±SD) age was 58.1±11.5 years. Most patients were expatriates (84.3%), of which Asian ethnicity was 66.7%. The mean (±SD) duration of osteoporosis was 2.82±1.8 years. Eleven (21.6%) patients had a history of fragility fracture. Ninety-six percent of the patients had vitamin D deficiency. One-third (29.4%) of the patients had hyperparathyroidism. Alendronate/cholecalciferol, received by nine patients (17.6%), showed a significant improvement (p=0.018) in the BMD of the femoral neck among the study group. In conclusion, the DXA scan as a monitoring tool has shown a significant improvement in the BMD of the femoral neck among patients taking alendronate/cholecalciferol treatment compared to other medications.

Published
2023
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2. Comprehensive description of the prevalence, serological and clinical characteristics, and visceral involvement of systemic sclerosis (scleroderma) in a large cohort from the United Arab Emirates Systemic Sclerosis Registry

Author

Rajaie Namas, Mohamed Elarabi, Saniya Khan, Asia Mubashir, Esat Memisoglu, Mahmoud El-Kaissi, Abhay Joshi, Jeffrey Chapman, Imad Jassim, Hiba Khogali, Nada Hassan, Hani Sabbour, Khaled Saleh, Khalid A. Alnaqbi, Ahmed S Zayat, Sehriban Diab, Zyiad Awir, Nehad Abu Taha, Amel Ginawi, Atheer Al Ansari, Hazem Rifaai, Zaid Alrawi, Afra Al Dhaheri, Gamal Ibrahim, Ahmed Abogamal, Waleed Al Shehhi, Jamal Teir, Tahir Khan, Maisam Musgrave, Beena Hameed, Bhavna Khan, Nagwa Mosallam, Nahla Hussien, Iman Hussein, Abeer Abdulelhamid, Ahmed Ali, Suad Hannawi, Mustafa Al Izzi, Humeira Badsha, and Jamal Al Saleh

Subjects
Rheumatology, Immunology, Immunology and Allergy
Abstract

Systemic sclerosis is an autoimmune condition characterized by a wide range of clinical presentations. Registries may serve to expand understanding about systemic sclerosis and aid in patient care and follow-up. The objective of this study was to analyze the prevalence of systemic sclerosis in a large cohort from the United Arab Emirates Systemic Sclerosis Registry and find the significant similarities and differences between the different subsets. All scleroderma patients in the United Arab Emirates were included in this multicenter national retrospective analysis. Data on demographics, comorbidities, serological characteristics, clinical aspects, and treatment were collected and analyzed, highlighting the most common traits identified. A total of 167 systemic scleroderma patients from diverse ethnic backgrounds were enrolled. Overall, 54.5% (91/167) of the patients were diagnosed with diffuse cutaneous systemic sclerosis, and 45.5% (76/167) with limited cutaneous systemic sclerosis. The prevalence of systemic sclerosis was 1.66 per 100,000 for the total registry and 7.78 per 100,000 for United Arab Emirates patients. Almost all patients in the diffuse cutaneous systemic sclerosis and limited cutaneous systemic sclerosis groups tested positive for the immunofluorescence antinuclear antibody. Antibodies against Scl-70 were significantly more associated with diffuse cutaneous systemic sclerosis, whereas anticentromere antibodies were significantly more associated with the limited cutaneous systemic sclerosis group ( p

Published
2023

3. Hypovitaminosis D among rheumatology outpatients in clinical practice

Author

David Halsall, A. J. Crisp, Nick Shenker, M. Mouyis, Amel Ginawi, Andrew J. K. Östör, Kenneth E. S. Poole, Poole, Kenneth [0000-0003-4546-7352], and Apollo - University of Cambridge Repository

Subjects
Adult, medicine.medical_specialty, Fibromyalgia, Inflammatory arthritis, Osteoporosis, Rickets, Immunopathology, vitamin D deficiency, Autoimmune Diseases, Clinical, chemistry.chemical_compound, Rheumatology, Internal medicine, Rheumatic Diseases, Autoimmune disease, medicine, Vitamin D and neurology, Humans, Pharmacology (medical), Vitamin D, Aged, Cholecalciferol, Retrospective Studies, business.industry, Middle Aged, medicine.disease, Vitamin D Deficiency, chemistry, Biochemical analysis, Physical therapy, Calcium, business
Abstract

OBJECTIVES: A role for vitamin D in the pathogenesis of autoimmune and inflammatory diseases is emerging. We undertook an audit of 25-hydroxyvitamin D (25OHD) investigation and treatment in rheumatology outpatients. METHODS: Serum 25OHD requests were matched to electronic medical records from rheumatology and metabolic bone clinics (April 2006-March 2007). Data were analysed separately for two groups, 'Documented osteoporosis/osteopaenia' (Group 1) and 'General rheumatology outpatients' (Group 2, sub-divided by diagnosis). Hypovitaminosis D was defined by 25OHD levels

Published
2020
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