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2. Right bundle branch block: a predictor of mortality in early systemic sclerosis.

Author

Hilda T Draeger, Shervin Assassi, Roozbeh Sharif, Emilio B Gonzalez, Brock E Harper, Frank C Arnett, Ameena Manzoor, Richard A Lange, and Maureen D Mayes

Subjects
Medicine, Science
Abstract

To evaluate the prognostic significance of baseline electrocardiogram (ECG) abnormalities in a multiethnic cohort of patients with early systemic sclerosis (SSc) and to determine the serological, clinical, and echocardiogram correlates of ECG findings.SSc patients with disease duration of≤5 years were enrolled in the GENISOS (Genetics versus Environment in Scleroderma Outcome Study) cohort. At the first visit, a standard 12 lead ECG was obtained along with demographic information, clinical data, and autoantibodies. The results of echocardiograms were also recorded. All ECGs were interpreted by a cardiologist unaware of the patients' clinical data.Of 265 SSc patients with average disease duration at enrollment of 2.5 years, 140 (52.8%) had abnormal ECG findings. These findings were not associated with SSc disease type or autoantibody profile but were associated with more severe heart and lung involvement. A total of 75 patients (28.3%) died over a follow up time of 9.9 years. Complete right bundle branch block (± left anterior hemiblock) on ECG, present in 7 (2.6%) patients, predicted a higher risk of mortality (HR: 5.3; 95% CI: 2.1 to 13.4; p

Published
2013
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3. Correction: Right Bundle Branch Block: A Predictor of Mortality in Early Systemic Sclerosis

Author

Ameena Manzoor, Shervin Assassi, Frank C. Arnett, Hilda T. Draeger, Roozbeh Sharif, Maureen D. Mayes, Richard A. Lange, Brock E. Harper, and Emilio B. Gonzalez

Subjects
medicine.medical_specialty, Multidisciplinary, business.industry, Science, lcsh:R, Correction, lcsh:Medicine, Right bundle branch block, medicine.disease, Internal medicine, Cardiology, Medicine, lcsh:Q, business, lcsh:Science
Abstract

The fifth author, Brock E. Harper, was incorrectly indicated as having contributed equally to the paper with the first and second authors.

Published
2014

4. Right Bundle Branch Block: A Predictor of Mortality in Early Systemic Sclerosis

Author

Ameena Manzoor, Hilda T. Draeger, Richard A. Lange, Shervin Assassi, Brock E. Harper, Emilio B. Gonzalez, Roozbeh Sharif, Maureen D. Mayes, and Frank C. Arnett

Subjects
Male, medicine.medical_specialty, Bundle-Branch Block, lcsh:Medicine, 030204 cardiovascular system & hematology, Cohort Studies, Coronary artery disease, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Risk of mortality, Humans, Medicine, cardiovascular diseases, Myocardial infarction, lcsh:Science, 030203 arthritis & rheumatology, Scleroderma, Systemic, Multidisciplinary, Bundle branch block, medicine.diagnostic_test, business.industry, lcsh:R, Middle Aged, Right bundle branch block, Prognosis, medicine.disease, 3. Good health, Cohort, Cardiology, lcsh:Q, Female, business, Research Article, Cohort study
Abstract

Objective To evaluate the prognostic significance of baseline electrocardiogram (ECG) abnormalities in a multiethnic cohort of patients with early systemic sclerosis (SSc) and to determine the serological, clinical, and echocardiogram correlates of ECG findings. Methods SSc patients with disease duration of≤5 years were enrolled in the GENISOS (Genetics versus Environment in Scleroderma Outcome Study) cohort. At the first visit, a standard 12 lead ECG was obtained along with demographic information, clinical data, and autoantibodies. The results of echocardiograms were also recorded. All ECGs were interpreted by a cardiologist unaware of the patients' clinical data. Results Of 265 SSc patients with average disease duration at enrollment of 2.5 years, 140 (52.8%) had abnormal ECG findings. These findings were not associated with SSc disease type or autoantibody profile but were associated with more severe heart and lung involvement. A total of 75 patients (28.3%) died over a follow up time of 9.9 years. Complete right bundle branch block (± left anterior hemiblock) on ECG, present in 7 (2.6%) patients, predicted a higher risk of mortality (HR: 5.3; 95% CI: 2.1 to 13.4; p

Published
2013

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