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Abstract Background Lymphoid neoplasm is a common disease, arising from lymphoid cells. It is divided into Hodgkin lymphoma and non-Hodgkin lymphoma. Non-Hodgkin lymphoma can be intranodular or extranodular, which happens in 25% of primary cases. The most common locations of extranodular non-Hodgkin lymphoma are the skin and gastrointestinal tract. The genital tract is a rare location; most lymphomas arise from the cervix and vagina, while the uterine corpus is an extremely rare location. In our case, the patient was diagnosed with primary extranodular non-Hodgkin lymphoma in different locations of her genital tract. Case presentation A 48-year-old nonparous Syrian woman complained of diffuse abdominal pain, fatigue, debility, high fever, vomiting, and urinary retention for a week. The last menstrual period of the patient was 5 years previously. The physical examination showed periodic abdominal pain with severe fatigue and increased abdominal size. The laboratory investigations were within normal limits except for a low level of hemoglobin and a high level of cancer antigen 125. The radiological investigations showed a uterine sizable lobulated mass with irregular borders and high and heterogeneous density, extending to the right and left ovaries, enlargement lymph nodes around the abdominal aortic and right iliac vessels, and severe right pleural effusion with right inferior lobe atelectasis. A total hysterectomy and oophorectomy were done. The histopathological examination showed that the patient had non-Hodgkin lymphoma (primary tumor). Conclusion Primary non-Hodgkin lymphoma in the female genital tract is an extremely rare disease. Fast diagnosis and treatment can improve the outcomes, so this differential diagnosis should be in our minds even in the absence of systematic manifestations of lymphoma. More studies are needed to explain the pathology of this disease and to put guidelines that determine the perfect methods for diagnosis and treatment.

The rod shape-determining protein, MreB, is a bacterial actin analog and is involved in determining the shape of nonspherical bacteria. A tertiary structure of MreB from Escherichia coli was constructed by an online server, RaptorX, and its accuracy was assessed by four validation tools. The docking software, AutoDock Vina was used to dock a total of onehundred natural occurring compounds obtained from ZINC and PubChem databases. The pharmacokinetics and toxicity profiles of the compounds were predicted by Swiss ADME tool. The results indicate that amentoflavone, rutin, and chlorogenic acid had binding affinities of -10.9, -10.1 and -9.3 Kcal/mol respectively which were higher than the control, ATP, -9.2 Kcal/mol. In the pharmacokinetic profiling, these three compounds were not inhibitors of cytochromes, but had a low gastrointestinal absorption. MreB may serve as an alternative molecular target for new antibiotics against rod-shape resistant microbes, since the disruption of its function may lead to bacterial cell lysis. [ABSTRACT FROM AUTHOR]