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3. The assessment of single nucleotide polymorphisms in the ß-tubulin genes in human soil-transmitted helminths exposed to different pressure with benzimidazole drugs

Author

Levecke, Bruno, primary, Rashwan, Nour, additional, Cools, Piet, additional, Albonico, Marco, additional, Ame, Shaali M, additional, Ayana, Mio, additional, Dana, Daniel, additional, Keiser, Jennifer, additional, Montresor, Antonio, additional, Mekonnen, Zeleke, additional, Roose, Sara, additional, Sayasone, Somphou, additional, Vercruysse, Jozef, additional, Verweij, Jaco J, additional, Vlaminck, Johnny, additional, and Prichard, Roger, additional

Published
2024
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4. Population genomics of ancient and modern Trichuris trichiura

Author

Doyle, Stephen R., Søe, Martin Jensen, Nejsum, Peter, Betson, Martha, Cooper, Philip J., Peng, Lifei, Zhu, Xing-Quan, Sanchez, Ana, Matamoros, Gabriela, Sandoval, Gustavo Adolfo Fontecha, Cutillas, Cristina, Tchuenté, Louis-Albert Tchuem, Mekonnen, Zeleke, Ame, Shaali M., Namwanje, Harriet, Levecke, Bruno, Berriman, Matthew, Fredensborg, Brian Lund, and Kapel, Christian Moliin Outzen

Published
2022
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6. Author Correction: Prediction of gestational age using urinary metabolites in term and preterm pregnancies

Author

Contrepois, Kévin, Chen, Songjie, Ghaemi, Mohammad S., Wong, Ronald J., Jehan, Fyezah, Sazawal, Sunil, Baqui, Abdullah H., Stringer, Jeffrey S. A., Rahman, Anisur, Nisar, Muhammad I., Dhingra, Usha, Khanam, Rasheda, Ilyas, Muhammad, Dutta, Arup, Mehmood, Usma, Deb, Saikat, Hotwani, Aneeta, Ali, Said M., Rahman, Sayedur, Nizar, Ambreen, Ame, Shaali M., Muhammad, Sajid, Chauhan, Aishwarya, Khan, Waqasuddin, Raqib, Rubhana, Das, Sayan, Ahmed, Salahuddin, Hasan, Tarik, Khalid, Javairia, Juma, Mohammed H., Chowdhury, Nabidul H., Kabir, Furqan, Aftab, Fahad, Quaiyum, Abdul, Manu, Alexander, Yoshida, Sachiyo, Bahl, Rajiv, Pervin, Jesmin, Price, Joan T., Rahman, Monjur, Kasaro, Margaret P., Litch, James A., Musonda, Patrick, Vwalika, Bellington, Shaw, Gary, Stevenson, David K., Aghaeepour, Nima, and Snyder, Michael P.

Published
2022
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9. RNA profiles reveal signatures of future health and disease in pregnancy

Author

Rasmussen, Morten, Reddy, Mitsu, Nolan, Rory, Camunas-Soler, Joan, Khodursky, Arkady, Scheller, Nikolai M., Cantonwine, David E., Engelbrechtsen, Line, Mi, Jia Dai, Dutta, Arup, Brundage, Tiffany, Siddiqui, Farooq, Thao, Mainou, Gee, Elaine P. S., La, Johnny, Baruch-Gravett, Courtney, Santillan, Mark K., Deb, Saikat, Ame, Shaali M., Ali, Said M., Adkins, Melanie, DePristo, Mark A., Lee, Manfred, Namsaraev, Eugeni, Gybel-Brask, Dorte Jensen, Skibsted, Lillian, Litch, James A., Santillan, Donna A., Sazawal, Sunil, Tribe, Rachel M., Roberts, James M., Jain, Maneesh, Høgdall, Estrid, Holzman, Claudia, Quake, Stephen R., Elovitz, Michal A., and McElrath, Thomas F.

Published
2022
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18. Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial

Author

Moser, Wendelin, Coulibaly, Jean T, Ali, Said M, Ame, Shaali M, Amour, Amour K, Yapi, Richard B, Albonico, Marco, Puchkov, Maxim, Huwyler, Jörg, Hattendorf, Jan, and Keiser, Jennifer

Published
2017
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22. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E., primary, Vlaminck, Johnny, additional, Cools, Piet, additional, Denwood, Matthew, additional, Albonico, Marco, additional, Ame, Shaali M., additional, Ayana, Mio, additional, Dana, Daniel, additional, Cringoli, Giuseppe, additional, de Vlas, Sake J., additional, Fenwick, Alan, additional, French, Michael, additional, Kazienga, Adama, additional, Keiser, Jennifer, additional, Knopp, Stefanie, additional, Leta, Gemechu, additional, Matoso, Leonardo F., additional, Maurelli, Maria P., additional, Montresor, Antonio, additional, Mirams, Greg, additional, Mekonnen, Zeleke, additional, Corrêa-Oliveira, Rodrigo, additional, Pinto, Simone A., additional, Rinaldi, Laura, additional, Sayasone, Somphou, additional, Steinmann, Peter, additional, Thomas, Eurion, additional, Vercruysse, Jozef, additional, and Levecke, Bruno, additional

Published
2023
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23. A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E., Vlaminck, Johnny, Cools, Piet, Denwood, Matthew, Albonico, Marco, Ame, Shaali M., Ayana, Mio, Dana, Daniel, Cringoli, Giuseppe, de Vlas, Sake J., Fenwick, Alan, French, Michael, Kazienga, Adama, Keiser, Jennifer, Knopp, Stefanie, Leta, Gemechu, Matoso, Leonardo F., Maurelli, Maria P., Montresor, Antonio, Mirams, Greg, Mekonnen, Zeleke, Corrêa-Oliveira, Rodrigo, Pinto, Simone A., Rinaldi, Laura, Sayasone, Somphou, Steinmann, Peter, Thomas, Eurion, Vercruysse, Jozef, Levecke, Bruno, Coffeng, Luc E., Vlaminck, Johnny, Cools, Piet, Denwood, Matthew, Albonico, Marco, Ame, Shaali M., Ayana, Mio, Dana, Daniel, Cringoli, Giuseppe, de Vlas, Sake J., Fenwick, Alan, French, Michael, Kazienga, Adama, Keiser, Jennifer, Knopp, Stefanie, Leta, Gemechu, Matoso, Leonardo F., Maurelli, Maria P., Montresor, Antonio, Mirams, Greg, Mekonnen, Zeleke, Corrêa-Oliveira, Rodrigo, Pinto, Simone A., Rinaldi, Laura, Sayasone, Somphou, Steinmann, Peter, Thomas, Eurion, Vercruysse, Jozef, and Levecke, Bruno

Abstract

Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendations, using a case study of therapeutic drug efficacy monitoring based on the examination of helminth eggs in stool. Methods We performed an in-depth analysis of the operational costs to process one stool sample for three diagnostic methods (Kato-Katz, Mini-FLOTAC and FECPAKG2). Next, we performed simulations to determine the probability of detecting a truly reduced therapeutic efficacy for different scenarios of STH species (Ascaris lumbricoides, Trichuris trichiura and hook-worms), pre-treatment infection levels, survey design (screen and select (SS); screen, select and retest (SSR) and no selection (NS)) and number of subjects enrolled (100– 5,000). Finally, we integrated the outcome of the cost assessment into the simulation study to estimate the total survey costs and determined the most cost-efficient survey design. Principal findings Kato-Katz allowed for both the highest sample throughput and the lowest cost per test, while FECPAKG2 required both the most laboratory time and was the most expensive. Counting of eggs accounted for 23% (FECPAKG2) or ≥80% (Kato-Katz and Mini-FLOTAC) of the total time-to-result. NS survey designs in combination with Kato-Katz were the most cost-efficient to assess therapeutic drug efficacy in all scenarios of STH species and endemicity. Conclusions/significance We confirm that Kato-Katz is the fecal egg counting method of choice for monitoring therapeutic drug efficacy, but that the survey design currently recommended by WHO (SS) should be updated. Our generic framework, which captures laboratory time and material costs, can be used to further support cost-efficient choices for other important surveys informing STH control programs. In addition, it can be used t

Published
2023

24. Risk factors of stillbirths in four district hospitals on Pemba Island, Tanzania:a prospective cohort study

Author

Skytte, Tine Bruhn, Holm-Hansen, Charlotte Carina, Ali, Said Mouhammed, Ame, Shaali, Molenaar, Jil, Greisen, Gorm, Poulsen, Anja, Sorensen, Jette Led, Lund, Stine, Skytte, Tine Bruhn, Holm-Hansen, Charlotte Carina, Ali, Said Mouhammed, Ame, Shaali, Molenaar, Jil, Greisen, Gorm, Poulsen, Anja, Sorensen, Jette Led, and Lund, Stine

Abstract

BACKGROUND: More than 2 million third-trimester stillbirths occur yearly, most of them in low- and middle-income countries. Data on stillbirths in these countries are rarely collected systematically. This study investigated the stillbirth rate and risk factors associated with stillbirth in four district hospitals in Pemba Island, Tanzania.METHODS: A prospective cohort study was completed between the 13th of September and the 29th of November 2019. All singleton births were eligible for inclusion. Events and history during pregnancy and indicators for adherence to guidelines were analysed in a logistic regression model that identified odds ratios [OR] with a 95% confidence interval [95% CI].RESULTS: A stillbirth rate of 22 per 1000 total births in the cohort was identified; 35.5% were intrapartum stillbirths (total number of stillbirths in the cohort, n = 31). Risk factors for stillbirth were breech or cephalic malpresentation (OR 17.67, CI 7.5-41.64), decreased or no foetal movements (OR 2.6, CI 1.13-5.98), caesarean section [CS] (OR 5.19, CI 2.32-11.62), previous CS (OR 2.63, CI 1.05-6.59), preeclampsia (OR 21.54, CI 5.28-87.8), premature rupture of membranes or rupture of membranes 18 h before birth (OR 2.5, CI 1.06-5.94) and meconium stained amniotic fluid (OR 12.03, CI 5.23-27.67). Blood pressure was not routinely measured, and 25% of women with stillbirths with no registered foetal heart rate [FHR] at admission underwent CS.CONCLUSIONS: The stillbirth rate in this cohort was 22 per 1000 total births and did not fulfil the Every Newborn Action Plan's goal of 12 stillbirths per 1000 total births in 2030. Awareness of risk factors associated with stillbirth, preventive interventions and improved adherence to clinical guidelines during labour, and hence improved quality of care, are needed to decrease the stillbirth rate in resource-limited settings.

Published
2023

29. A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study

Author

Coffeng, Luc E, primary, Vlaminck, Johnny, additional, Cools, Piet, additional, Denwood, Matthew, additional, Albonico, Marco, additional, Ame, Shaali M, additional, Ayana, Mio, additional, Dana, Daniel, additional, Cringoli, Giuseppe, additional, de Vlas, Sake J, additional, Fenwick, Alan, additional, French, Michael, additional, Kazienga, Adama, additional, Keiser, Jennifer, additional, Knopp, Stefanie, additional, Leta, Gemechu, additional, Matoso, Leonardo F., additional, Maurelli, Maria P., additional, Montresor, Antonio, additional, Mirams, Greg, additional, Mekonnen, Zeleke, additional, Corrêa-Oliveira, Rodrigo, additional, Pinto, Simone A., additional, Rinaldi, Laura, additional, Sayasone, Somphou, additional, Steinmann, Peter, additional, Thomas, Eurion, additional, Vercruysse, Jozef, additional, and Levecke, Bruno, additional

Published
2023
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31. Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands

Author

Pennance, Tom, primary, Neves, M. Inês, additional, Webster, Bonnie L., additional, Gower, Charlotte M., additional, Knopp, Stefanie, additional, Khamis, Iddi Simba, additional, Ame, Shaali M., additional, Ali, Said M., additional, Rabone, Muriel, additional, Emery, Aidan, additional, Allan, Fiona, additional, Muhsin, Mtumweni Ali, additional, Suleiman, Khamis Rashid, additional, Kabole, Fatama, additional, Walker, Martin, additional, Rollinson, David, additional, and Webster, Joanne P., additional

Published
2022
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34. Neonatal mortality within 24 hours of birth in six low- and lower-middle-income countries/Mortalite neonatale dans les 24 heures suivant la naissance dans six pays a revenu faible et intermediaire--tranche inferieure/Mortalidad neonatal durante las 24 horas posteriores al nacimiento en paises con ingresos bajos y paises con ingresos medios mas bajos

Author

Baqui, Abdullah H., Mitra, Dipak K., Begum, Nazma, Hurt, Lisa, Soremekun, Seyi, Edmond, Karen, Kirkwood, Betty, Bhandari, Nita, Taneja, Sunita, Mazumder, Sarmila, Nisar, Muhammad Imran, Jehan, Fyezah, Ilyas, Muhammad, Ali, Murtaza, Ahmed, Imran, Ariff, Shabina, Soofi, Sajid B., Sazawal, Sunil, Dhingra, Usha, Dutta, Arup, Ali, Said M., Ame, Shaali M., Semrau, Katherine, Hamomba, Fern M., Grogan, Caroline, Hamer, Davidson H., Bahl, Rajiv, Yoshida, Sachiyo, and Manu, Alexander

Subjects
Infants -- Patient outcomes, Epidemiology -- Comparative analysis -- Health aspects -- Research, Infants (Newborn) -- Comparative analysis -- Health aspects -- Research, Health, World Health Organization, United Nations
Abstract

Objective To estimate neonatal mortality, particularly within 24 hours of birth, In six low- and lower-middle-income countries. Methods We analysed epidemiological data on a total of 149 570 live births collected between 2007 and 2013 In six prospective randomized trials and a cohort study from predominantly rural areas of Bangladesh, Ghana, India, Pakistan, the United Republic of Tanzania and Zambia. The neonatal mortality rate and mortality within 24 hours of birth were estimated for all countries and mortality within 6 hours was estimated for four countries with available data. The findings were compared with published model-based estimates of neonatal mortality. Findings Overall, the neonatal mortality rate observed at study sites in the six countries was 30.5 per 1000 live births (range: 13.6 in Zambia to 47.4 in Pakistan). Mortality within 24 hours was 14.1 per 1000 live births overall (range: 5.1 in Zambia to 20.1 in India) and 46.3% of all neonatal deaths occurred within 24 hours (range: 36.2% in Pakistan to 65.5% in the United Republic of Tanzania). Mortality in the first 6 hours was 8.3 per 1000 live births, i.e. 31.9% of neonatal mortality. Conclusion Neonatal mortality within 24 hours of birth in predominantly rural areas of six low-and lower-middle-income countries was higher than model-based estimates for these countries. A little under half of all neonatal deaths occurred within 24 hours of birth and around one third occurred within 6 hours. Implementation of high-quality, effective obstetric and early newborn care should be a priority in these settings. Methodes Nous avons analyse des donnees epidemiologiques portant sur un total de 149 570 naissances vivantes qui avaient ete recueillies entre 2007 et 2013 lors de six essais prospectifs randomises et d'une etude de cohorte realises dans des zones majoritairement rurales du Bangladesh, du Ghana, d'Inde, du Pakistan, de Tanzanie et de Zambie. Le taux de mortalite neonatale ainsi que la mortalite dans les 24 heures suivant la naissance ont ete estimes pour tous ces pays; la mortalite dans les 6 heures suivant la naissance a ete estimee pour quatre pays sur lesquels nous avions des donnees. Les resultats ont ete compares aux estimations de la mortalite neonatale publiees, qui ont ete etablies d'apres des modeles. Resultats Globalement, le taux de mortalite neonatale observe sur les sites etudies dans les six pays etait de 30,5 pour 1000 naissances vivantes (de 13,6 en Zambie a 47,4 au Pakistan). La mortalite globale dans les 24 heures suivant la naissance etait de 14,1 pour 1000 naissances vivantes (de 5,1 en Zambie a 20,1 en Inde) et 46,3% de l'ensemble des deces neonataux etaient survenus dans les 24 heures (de 36,2% au Pakistan a 65,5% en Tanzanie). Le taux de mortalite dans les 6 heures suivant la naissance etait de 8,3 pour 1000 naissances vivantes, soit 31,9% de la mortalite neonatale totale. Conclusion La mortalite neonatale dans les 24 heures suivant la naissance dans des zones majoritairement rurales de six pays a revenu faible et intermediaire-tranche inferieure etait superieure aux estimations etablies d'apres des modeles pour ces pays. Un peu moins de la moitie des deces neonataux etaient survenus dans les 24 heures suivant la naissance et environ un tiers dans les 6 heures. La mise en place de soins obstetriques et neonataux efficaces et de haute qualite devrait etre une priorite dans ces pays. Mortalidad neonatal durante las 24 horas posteriores al nacimiento en paises con ingresos bajos y paises con ingresos medios mas bajos Objetivo Calcular la mortalidad neonatal, especialmente durante las 24 horas posteriores al nacimiento, en paises con ingresos bajos y paises con ingresos medios mas bajos. Metodos Se analizaron datos epidemiologicos de un total de 149 570 nacidos vivos recopilados entre 2007 y 2013 en seis ensayos a leatorizados prospectivos y un estudio de cohortes de zonas principalmente rurales de Bangladesh, Ghana, india, Pakistan, la Republica Unida de Tanzania y Zambia. Se calculo la tasa de mortalidad neonatal y la mortalidad durante las 24 horas posteriores al nacimiento en todos los paises y se estimo la tasa de mortalidad en 6 horas en cuatro paises con informacion disponible. Los resultados se compararon con estimaciones publicadas basadas en modelos de mortalidad neonatal. Resultados En general, la tasa de mortalidad neonatal observada en los lugares de' estudio de los seis paises fue de 30,5 por cada 1 000 nacidos vivos (alcance: 13,6 en Zambia a 47,4en Pakistan). En conjunto, la mortalidad durante las primeras 24 horas fue de 14,1 porcada 1 000 nacidos vivos (alcance: 5,1 en Zambia a 20,1 en India) y el 46,3% de todas las muertes neonatales se produjo durante las primeras 24 horas (alcance: 36,2% en Pakistan a 65,5% en la Republica Unida deTanzania). La mortalidad en las primeras 6 horas fue de 8,3 porcada 1 000 nacidos vivos, es decir, un 31,9% de mortalidad neonatal. Conclusion La mortalidad neonatal durante las 24 horas posteriores al nacimiento en zonas principalmente rurales de seis paises con ingresos bajos y paises con ingresos medios mas bajos fue superior a las estimaciones basadas en modelos realizadas para estos paises. Algo menos de la mitad de todas las muertes neonatales se produjeron durante las 24 horas posteriores al nacimiento y cerca de un tercio durante las primeras 6 horas de vida. En estos lugares, la implementadon de obstetricia eficaz y de alta calidad y la atencion a recien nacidos deberia ser una prioridad., Introduction Neonatal mortality remains unacceptably high and the risk is greatest on the first day of life--these were the conclusions of the 14th annual State of the World's Mothers report, [...]

Published
2016
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35. Transmission and diversity of Schistosoma haematobium and S. bovis and their freshwater intermediate snail hosts Bulinus globosus and B. nasutus in the Zanzibar Archipelago, United Republic of Tanzania

Author

Pennance, Tom, primary, Ame, Shaali Makame, additional, Amour, Amour Khamis, additional, Suleiman, Khamis Rashid, additional, Muhsin, Mtumweni Ali, additional, Kabole, Fatma, additional, Ali, Said Mohammed, additional, Archer, John, additional, Allan, Fiona, additional, Emery, Aidan, additional, Rabone, Muriel, additional, Knopp, Stefanie, additional, Rollinson, David, additional, Cable, Joanne, additional, and Webster, Bonnie L., additional

Published
2022
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37. Affordable artificial intelligence-based digital pathology for neglected tropical diseases: A proof-of-concept for the detection of soil-transmitted helminths and Schistosoma mansoni eggs in Kato-Katz stool thick smears

Author

Ward, Peter, primary, Dahlberg, Peter, additional, Lagatie, Ole, additional, Larsson, Joel, additional, Tynong, August, additional, Vlaminck, Johnny, additional, Zumpe, Matthias, additional, Ame, Shaali, additional, Ayana, Mio, additional, Khieu, Virak, additional, Mekonnen, Zeleke, additional, Odiere, Maurice, additional, Yohannes, Tsegaye, additional, Van Hoecke, Sofie, additional, Levecke, Bruno, additional, and Stuyver, Lieven J., additional

Published
2022
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38. Prediction of gestational age using urinary metabolites in term and preterm pregnancies

Author

Contrepois, Kévin, Chen, Songjie, Ghaemi, Mohammad S., Wong, Ronald J., Jehan, Fyezah, Sazawal, Sunil, Baqui, Abdullah H., Nisar, Muhammad I., Dhingra, Usha, Khanam, Rasheda, Ilyas, Muhammad, Dutta, Arup, Mehmood, Usma, Deb, Saikat, Hotwani, Aneeta, Ali, Said M., Rahman, Sayedur, Nizar, Ambreen, Ame, Shaali M., Muhammad, Sajid, Chauhan, Aishwarya, Khan, Waqasuddin, Raqib, Rubhana, Das, Sayan, Ahmed, Salahuddin, Hasan, Tarik, Khalid, Javairia, Juma, Mohammed H., Chowdhury, Nabidul H., Kabir, Furqan, Aftab, Fahad, Quaiyum, Md Abdul, Manu, Alexander, Yoshida, Sachiyo, Bahl, Rajiv, Rahman, Anisur, Pervin, Jesmin, Price, Joan T., Rahman, Monjur, Kasaro, Margaret P., Litch, James A., Musonda, Patrick, Vwalika, Bellington, Stringer, Jeffrey S. A., Shaw, Gary, Stevenson, David K., Aghaeepour, Nima, and Snyder, Michael P.

Subjects
Cohort Studies, Multidisciplinary, Pregnancy, Infant, Newborn, Humans, Metabolomics, Female, Gestational Age, Ultrasonography, Prenatal, Chromatography, Liquid
Abstract

Assessment of gestational age (GA) is key to provide optimal care during pregnancy. However, its accurate determination remains challenging in low- and middle-income countries, where access to obstetric ultrasound is limited. Hence, there is an urgent need to develop clinical approaches that allow accurate and inexpensive estimations of GA. We investigated the ability of urinary metabolites to predict GA at time of collection in a diverse multi-site cohort of healthy and pathological pregnancies (n = 99) using a broad-spectrum liquid chromatography coupled with mass spectrometry (LC–MS) platform. Our approach detected a myriad of steroid hormones and their derivatives including estrogens, progesterones, corticosteroids, and androgens which were associated with pregnancy progression. We developed a restricted model that predicted GA with high accuracy using three metabolites (rho = 0.87, RMSE = 1.58 weeks) that was validated in an independent cohort (n = 20). The predictions were more robust in pregnancies that went to term in comparison to pregnancies that ended prematurely. Overall, we demonstrated the feasibility of implementing urine metabolomics analysis in large-scale multi-site studies and report a predictive model of GA with a potential clinical value.

Published
2022

39. Video recording as an objective assessment tool of health worker performance in neonatal resuscitation at a district hospital in Pemba, Tanzania:a feasibility study

Author

Holm-Hansen, Charlotte Carina, Poulsen, Anja, Skytte, Tine Bruhn, Stensgaard, Christina Nadia, Bech, Christine Manich, Lopes, Mads Nathaniel, Kristiansen, Mads, Kjærgaard, Jesper, Mzee, Said, Ali, Said, Ame, Shaali, Sorensen, Jette Led, Greisen, Gorm, Lund, Stine, Holm-Hansen, Charlotte Carina, Poulsen, Anja, Skytte, Tine Bruhn, Stensgaard, Christina Nadia, Bech, Christine Manich, Lopes, Mads Nathaniel, Kristiansen, Mads, Kjærgaard, Jesper, Mzee, Said, Ali, Said, Ame, Shaali, Sorensen, Jette Led, Greisen, Gorm, and Lund, Stine

Abstract

OBJECTIVES: To assess the feasibility of using video recordings of neonatal resuscitation (NR) to evaluate the quality of care in a low-resource district hospital.DESIGN: Prospective observational feasibility study.SETTING: Chake-Chake Hospital, a district hospital in Pemba, Tanzania, in April and May 2019.PARTICIPANTS: All delivering women and their newborns were eligible for participation.MAIN OUTCOME MEASURES: Motion-triggered cameras were mounted on resuscitation tables and provided recordings that were analysed for quality of care indicators based on the national NR algorithm. Assessment of feasibility was conducted using Bowen's 8-point framework for feasibility studies.RESULTS: 91% (126 of 139) of women and 96% (24 of 26) of health workers were comfortable or very comfortable with the video recordings. Of 139 newborns, 8 underwent resuscitation with bag and mask ventilation. In resuscitations, heat loss prevention measures were not performed in half of the cases (four of eight), clearing the airway was not performed correctly in five of eight cases, and all newborns were suctioned vigorously and repeatedly, even when not indicated. In a quarter (two of eight) of cases, the newborn's head was not positioned correctly. Additionally, two of the eight newborns needing ventilation were not ventilated within the first minute of life. In none of the eight cases did ventilation appear to be performed effectively.CONCLUSIONS: It proved feasible to use video recordings to assess quality of care during NR in a low-resource setting, and the method was considered acceptable for the delivering women and health workers. Recordings of eight resuscitations all demonstrated deviations from NR guidelines.

Published
2022

40. Video recording as an objective assessment tool of health worker performance in neonatal resuscitation at a district hospital in Pemba, Tanzania: a feasibility study

Author

Holm-Hansen, Charlotte Carina, primary, Poulsen, Anja, additional, Skytte, Tine Bruhn, additional, Stensgaard, Christina Nadia, additional, Bech, Christine Manich, additional, Lopes, Mads Nathaniel, additional, Kristiansen, Mads, additional, Kjærgaard, Jesper, additional, Mzee, Said, additional, Ali, Said, additional, Ame, Shaali, additional, Sorensen, Jette Led, additional, Greisen, Gorm, additional, and Lund, Stine, additional

Published
2022
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41. Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs

Author

Katherine E. Halliday, Bruno Levecke, Roy M. Anderson, Veronica Malizia, Piet Cools, Paul M. Gichuki, Zeleke Mekonnen, Johnny Vlaminck, Ame Shaali, Luc E. Coffeng, Rajiv Sarkar, Sake J. de Vlas, Carolin Vegvari, Somphou Sayasone, The Task Force for Global Health, and Public Health

Subjects
0301 basic medicine, HOOKWORM INFECTION, Kato-Katz, Computer science, Helminthiasis, Datasets as Topic, Supplement Articles, Feces, Soil, fluids and secretions, 0302 clinical medicine, Policy decision, Preventive Health Services, Statistics, Medicine and Health Sciences, Immunology and Allergy, 11 Medical and Health Sciences, Sampling (statistics), Soil-transmitted helminthiasis, COMMUNITY, AcademicSubjects/MED00290, Infectious Diseases, Kato katz, Life Sciences & Biomedicine, fecal egg counts, Immunology, Decision Making, prevalence, 030231 tropical medicine, Sample (statistics), Stool specimen, Microbiology, Sensitivity and Specificity, Specimen Handling, 03 medical and health sciences, medicine, Statistical precision, Humans, AcademicSubjects/MED00860, Parasite Egg Count, soil-transmitted helminths, Science & Technology, Biology and Life Sciences, 06 Biological Sciences, moderate-to-heavy infection, medicine.disease, 030104 developmental biology, Earth and Environmental Sciences, EGG COUNTS
Abstract

Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.

Published
2019

43. Population genomics of ancient and modernTrichuris trichiura

Author

Doyle, Stephen R., primary, Søe, Martin Jensen, additional, Nejsum, Peter, additional, Betson, Martha, additional, Cooper, Philip J., additional, Peng, Lifei, additional, Zhu, Xing-Quan, additional, Sanchez, Ana, additional, Matamoros, Gabriela, additional, Fontecha Sandoval, Gustavo Adolfo, additional, Cutillas, Cristina, additional, Tchuenté, Louis-Albert Tchuem, additional, Mekonnen, Zeleke, additional, Ame, Shaali M., additional, Namwanje, Harriet, additional, Levecke, Bruno, additional, Berriman, Matthew, additional, Fredensborg, Brian Lund, additional, and Outzen Kapel, Christian Moliin, additional

Published
2021
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44. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure

Author

Walker, Martin, primary, Cools, Piet, additional, Albonico, Marco, additional, Ame, Shaali M., additional, Ayana, Mio, additional, Dana, Daniel, additional, Keiser, Jennifer, additional, Matoso, Leonardo F., additional, Montresor, Antonio, additional, Mekonnen, Zeleke, additional, Corrêa-Oliveira, Rodrigo, additional, Pinto, Simone A,, additional, Sayasone, Somphou, additional, Vercruysse, Jozef, additional, Vlaminck, Johnny, additional, and Levecke, Bruno, additional

Published
2021
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45. Characterization of the β-tubulin gene family in Ascaris lumbricoides and Ascaris suum and its implication for the molecular detection of benzimidazole resistance

Author

Roose, Sara, primary, Avramenko, Russell W., additional, Pollo, Stephen M. J., additional, Wasmuth, James D., additional, Ame, Shaali, additional, Ayana, Mio, additional, Betson, Martha, additional, Cools, Piet, additional, Dana, Daniel, additional, Jones, Ben P., additional, Mekonnen, Zeleke, additional, Morosetti, Arianna, additional, Venkatesan, Abhinaya, additional, Vlaminck, Johnny, additional, Workentine, Matthew L., additional, Levecke, Bruno, additional, Gilleard, John S., additional, and Geldhof, Peter, additional

Published
2021
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48. RNA profiles reveal signatures of future health and disease in pregnancy

Author

Rasmussen, Morten, Reddy, Mitsu, Nolan, Rory, Camunas-Soler, Joan, Khodursky, Arkady, Scheller, Nikolai M., Cantonwine, David E., Engelbrechtsen, Line, Mi, Jia Dai, Dutta, Arup, Brundage, Tiffany, Siddiqui, Farooq, Thao, Mainou, Gee, Elaine P. S., La, Johnny, Baruch-Gravett, Courtney, Santillan, Mark K., Deb, Saikat, Ame, Shaali M., Ali, Said M., Adkins, Melanie, DePristo, Mark A., Lee, Manfred, Namsaraev, Eugeni, Gybel-Brask, Dorte Jensen, Skibsted, Lillian, Litch, James A., Santillan, Donna A., Sazawal, Sunil, Tribe, Rachel M., Roberts, James M., Jain, Maneesh, Høgdall, Estrid, Holzman, Claudia, Quake, Stephen R., Elovitz, Michal A., and McElrath, Thomas F.

Subjects
EXPRESSION, Multidisciplinary, MOUSE, Predictive markers, Sensitivity and Specificity, Article, KIDNEY, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, CELLS, Humans, RNA, Female, Gene expression, GESTATIONAL-AGE, Cell-Free Nucleic Acids, FETAL, Retrospective Studies
Abstract

Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden1. Yet the ability to assess underlying pathophysiology before clinical presentation to enable identification of pregnancies at risk remains elusive. Here we demonstrate the ability of plasma cell-free RNA (cfRNA) to reveal patterns of normal pregnancy progression and determine the risk of developing pre-eclampsia months before clinical presentation. Our results centre on comprehensive transcriptome data from eight independent prospectively collected cohorts comprising 1,840 racially diverse pregnancies and retrospective analysis of 2,539 banked plasma samples. The pre-eclampsia data include 524 samples (72 cases and 452 non-cases) from two diverse independent cohorts collected 14.5 weeks (s.d., 4.5 weeks) before delivery. We show that cfRNA signatures from a single blood draw can track pregnancy progression at the placental, maternal and fetal levels and can robustly predict pre-eclampsia, with a sensitivity of 75% and a positive predictive value of 32.3% (s.d., 3%), which is superior to the state-of-the-art method2. cfRNA signatures of normal pregnancy progression and pre-eclampsia are independent of clinical factors, such as maternal age, body mass index and race, which cumulatively account for less than 1% of model variance. Further, the cfRNA signature for pre-eclampsia contains gene features linked to biological processes implicated in the underlying pathophysiology of pre-eclampsia., Expression signatures from cell-free RNA of pregnant women can be used to reveal normal biology of pregnancy and predict development of pre-eclampsia.

Published
2021

49. Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: Results from randomized controlled trials in Lao PDR and Pemba Island, Tanzania

Author

Keller, Ladina, primary, Welsche, Sophie, additional, Patel, Chandni, additional, Sayasone, Somphou, additional, Ali, Said M., additional, Ame, Shaali M., additional, Hattendorf, Jan, additional, Hürlimann, Eveline, additional, and Keiser, Jennifer, additional

Published
2021
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50. Additional file 4 of Dissection of the gut microbiota in mothers and children with chronic Trichuris trichiura infection in Pemba Island, Tanzania

Author

Chen, Hongliang, Mozzicafreddo, Matteo, Pierella, Elisa, Carletti, Vanessa, Piersanti, Angela, Ali, Said M., Ame, Shaali M., Wang, Chunfeng, and Miceli, Cristina

Subjects
fluids and secretions, parasitic diseases
Abstract

Additional file 4: Table S2. Statistical difference of pairwise comparisons at phylum level. Abbreviations: MP, mother helminth-positive group; MN, mother helminth-negative group; CP, children helminth-positive group; CN, children helminth-negative group.

Published
2021
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