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4. COPD: Providing the right treatment for the right patient at the right time

Author

Agusti, Alvar, Ambrosino, Nicolino, Blackstock, Felicity, Bourbeau, Jean, Casaburi, Richard, Celli, Bartolome, Criner, Gerard J., Crouch, Rebecca, Negro, Roberto W. Dal, Dreher, Michael, Garvey, Chris, Gerardi, Daniel A., Goldstein, Roger, Hanania, Nicola A., Holland, Anne E., Kaur, Antarpreet, Lareau, Suzanne, Lindenauer, Peter K., Mannino, David, Make, Barry, Maltais, François, Marciniuk, Jeffrey D., Meek, Paula, Morgan, Mike, Pepin, Jean-Louis, Reardon, Jane Z., Rochester, Carolyn L., Singh, Sally, Spruit, Martijn A., Steiner, Michael C., Troosters, Thierry, Vitacca, Michele, Clini, Enico, Jardim, Jose, Nici, Linda, Raskin, Jonathan, and ZuWallack, Richard

Published
2023
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23. High-Flow Oxygen Therapy During Exercise Training in Patients With Chronic Obstructive Pulmonary Disease and Chronic Hypoxemia: A Multicenter Randomized Controlled Trial

Author

Vitacca, Michele, Paneroni, Mara, Zampogna, Elisabetta, Visca, Dina, Carlucci, Annalisa, Cirio, Serena, Banf, Paolo, Pappacoda, Gabriele, Trianni, Ludovico, Brogneri, Antonio, Belli, Stefano, Paracchini, Elena, Aliani, Maria, Spinelli, Vito, Gigliotti, Francesco, Lanini, Barbara, Lazzeri, Marta, Clini, Enrico M., Malovini, Alberto, and Ambrosino, Nicolino

Subjects
Anoxemia -- Analysis, Chronic obstructive lung disease -- Analysis, Patient satisfaction -- Analysis, Health
Abstract

Objective. The study aimed to evaluate whether high-flow oxygen therapy (HFOT) during training was more effective than oxygen in improving exercise capacity in hypoxemic chronic obstructive pulmonary disease (COPD). Methods. A total of 171 patients with COPD and chronic hypoxemia were consecutively recruited in 8 rehabilitation hospitals in a randomized controlled trial. Cycle-ergometer exercise training was used in 20 supervised sessions at iso inspiratory oxygen fraction in both groups. Pre- and post-training endurance time (Tlim), 6-minute walking distance (6MWD), respiratory and limb muscle strength, arterial blood gases, Barthel Index, Barthel Dyspnea Index, COPD Assessment Test, Maugeri Respiratory Failure questionnaire, and patient satisfaction were evaluated. Results. Due to 15.4% and 24.1% dropout rates, 71 and 66 patients were analyzed in HFOT and Venturi mask (V-mask) groups, respectively. Exercise capacity significantly improved after training in both groups with similar patient satisfaction. Between-group difference in post-training improvement in 6MWD (mean: 17.14 m; 95% CI = 0.87 to 33.43 m) but not in Tlim (mean: 141.85 seconds; 95% CI = -18.72 to 302.42 seconds) was significantly higher in HFOT. The minimal clinically important difference of Tlim was reached by 47% of patients in the V-mask group and 56% of patients in the HFOT group, whereas the minimal clinically important difference of 6MWD was reached by 51% of patients in the V-mask group and 69% of patients in the HFOT group, respectively. Conclusion. In patients with hypoxemic COPD, exercise training is effective in improving exercise capacity. Impact Statement. The addition of HFOT during exercise training is not more effective than oxygen through V-mask in improving endurance time, the primary outcome, whereas it is more effective in improving walking distance., Pulmonary rehabilitation, including aerobic exercise training, has stronger evidence of effectiveness to improve exercise capacity, dyspnea, and health-related quality of life (HRQL) than almost all other therapies in patients with [...]

Published
2020
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24. Incorporating telemedicine into the integrated care of the COPD patient a summary of an interdisciplinary workshop held in Stresa, Italy, 7–8 September 2017

Author

Donner, Claudio F., Raskin, Jonathan, ZuWallack, Richard, Nici, Linda, Ambrosino, Nicolino, Balbi, Bruno, Blackstock, Felicity, Casaburi, Richard, Dreher, Michael, Effing, Tanja, Goldstein, Roger, Krishnan, Jerry, Lareau, Suzanne C., Make, Barry J., Maltais, Francois, Meek, Paula, Morgan, Michael, Pépin, Jean-Louis, Rabbito, Chiara, Rochester, Carolyn L., Silverman, Adam R., Singh, Sally, Spruit, Martijn A., Vitacca, Michele, and Williams, Loreen

Published
2018
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