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281 results on '"Amblard F"'

1. Approaches to hepatitis C treatment and cure using NS5A inhibitors

Author

Kohler JJ, Nettles JH, Amblard F, Hurwitz SJ, Bassit L, Stanton RA, Ehteshami M, and Schinazi RF

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

James J Kohler,1,2 James H Nettles,1,2 Franck Amblard,1,2 Selwyn J Hurwitz,1,2 Leda Bassit,1,2 Richard A Stanton,1 Maryam Ehteshami,1 Raymond F Schinazi1,2 1Center for AIDS Research and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; 2Atlanta Veterans Affairs Medical Center, Decatur, GA, USA Abstract: Recent progress in the understanding of hepatitis C virus (HCV) biology and the availability of in vitro models to study its replication have facilitated the development of direct-acting antiviral agents (DAAs) that target specific steps in the viral replication cycle. Currently, there are three major classes of DAA in clinical development: NS3/4A protease inhibitors, NS5B polymerase inhibitors, and NS5A directed inhibitors. Several compounds thought to bind directly with NS5A are now in various clinical trial phases, including the most advanced, daclatasvir (BMS-790052), ledipasvir (GS-5885), and ABT-267. While many NS5A-targeted compounds demonstrate picomolar potency, the exact mechanism(s) of their action is still unclear. In the clinic, NS5A HCV inhibitors show promise as important components in DAA regimens and have multifunctionality. In addition to inhibiting viral replication, they may synergize with other DAAs, possibly by modulating different viral proteins, to help suppress the emergence of resistant viruses. Structure-based models have identified target interaction domains and spatial interactions that explain drug resistance for mutations at specific positions (eg, residues 93 and 31) within NS5A and potential binding partners. This review provides, insights into the unique complexity of NS5A as a central platform for multiple viral/host protein interactions, and possible mechanism(s) for the NS5A inhibitors currently undergoing clinical trials that target this nonstructural viral protein. Keywords: HCV replication complex, direct acting antivirals (DAAs), clinical trials

Published
2014

3. The role of network topology on extremism propagation with the Relative Agreement opinion dynamics

Author

Amblard, F. and Deffuant, G.

Subjects
Condensed Matter - Other Condensed Matter
Abstract

In (Deffuant et al., 2002), we proposed a simple model of opinion dynamics, which we used to simulate the influence of extremists in a population. Simulations were run without any specific interaction structure and varying the simulation parameters, we observed different attractors such as predominance of centrism or of extremism. We even observed in certain conditions, that the whole population drifts to one extreme of the opinion, even if initially there are an equal number of extremists at each extreme of the opinion axis. In the present paper, we study the influence of the social networks on the presence of such a dynamical behavior. In particular, we use small-world networks with variable connectivity and randomness of the connections. We find that the drift to a single extreme appears only beyond a critical level of connectivity, which decreases when the randomness increases., Comment: 15 pages, 9 figures

Published
2004
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6. A Coordination Framework Based on the Sociology of Organized Action

Author

Sibertin-Blanc, C., Amblard, F., Mailliard, M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Boissier, Olivier, editor, Padget, Julian, editor, Dignum, Virginia, editor, Lindemann, Gabriela, editor, Matson, Eric, editor, Ossowski, Sascha, editor, Sichman, Jaime Simão, editor, and Vázquez-Salceda, Javier, editor

Published
2006
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8. Interacting Agents and Continuous Opinions Dynamics

Author

Weisbuch, G., Deffuant, G., Amblard, F., Nadal, J.-P., Beckmann, M., editor, Künzi, H. P., editor, Fandel, G., editor, Trockel, W., editor, Aliprantis, C. D., editor, Basile, A., editor, Drexl, A., editor, Feichtinger, G., editor, Güth, W., editor, Inderfurth, K., editor, Korhonen, P., editor, Kürsten, W., editor, Schittko, U., editor, Schönfeld, P., editor, Selten, R., editor, Steuer, R., editor, Vega-Redondo, F., editor, Cowan, Robin, editor, and Jonard, Nicolas, editor

Published
2003
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12. Regulation of Antigen-Independent Adhesion of CD4 T Cells

Author

Mazerolles, Fabienne, Amblard, F., Lecomte, O., Meloche, S., Barbat, C., Hauss, P., Hivroz, C., Sekaly, R., Fischer, A., Lipsky, Peter E., editor, Rothlein, Robert, editor, Kishimoto, Takashi Kei, editor, Faanes, Ronald B., editor, and Smith, C. Wayne, editor

Published
1993
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13. Pregnancy outcomes of prenatally diagnosed Turner syndrome: a French multicenter retrospective study including a series of 975 cases

Author

Gruchy, N., Vialard, F., Blondeel, E., Le Meur, N., Joly-Hélas, G., Chambon, P., Till, M., Herbaut-Graux, M., Vigouroux-Castera, A., Coussement, A., Lespinasse, J., Amblard, F., Jimenez, M., Lebel Roy Camille, L., Carré-Pigeon, F., Flori, E., Mugneret, F., Jaillard, S., Yardin, C., Harbuz, R., Collonge Rame, M., Vago, P., Valduga, M., and Leporrier, N.

Published
2014
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14. A French collaborative survey of 272 fetuses with 22q11.2 deletion: ultrasound findings, fetal autopsies and pregnancy outcomes

Author

Besseau-Ayasse, J., Violle-Poirsier, C., Bazin, A., Gruchy, N., Moncla, A., Girard, F., Till, M., Mugneret, F., Coussement, A., Pelluard, F., Jimenez, M., Vago, P., Portnoï, M. F., Dupont, C., Beneteau, C., Amblard, F., Valduga, M., Bresson, J. L., Carré-Pigeon, F., Le Meur, N., Tapia, S., Yardin, C., Receveur, A., Lespinasse, J., Pipiras, E., Beaujard, M. P., Teboul, P., Brisset, S., Catty, M., Nowak, E., Douet Guilbert, N., Lallaoui, H., Bouquillon, S., Gatinois, V., Joly-Helas, G., Prieur, F., Cartault, F., Martin, D., Kleinfinger, P., Molina Gomes, D., Doco-Fenzy, M., and Vialard, F.

Published
2014
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20. French multi-centric study of 2000 amniotic fluid interphase FISH analyses from high-risk pregnancies and review of the literature

Author

Luquet, I, Mugneret, F, Athis, P.D, Nadal, N, Favre, B, Abel, C, Chelloug, N, Lespinasse, J, Portnoi, M.F, Joyé, N, Dupont, J.M, Lebbar, A, Bresson, J.L, Fellmann, F, Siffroi, J.P, Chantot-Bastaraud, S, Chiesa, J, Amblard, F, Devillard, F, Jeandidier, E, Boceno, M, Rival, J.M, Bellec, V, Lallaoui, H, Delobel, B, Croquette, M.F, and Benzacken, B

Published
2002
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21. 2.4A resolution structure of human Norovirus GII.4 protease

Author

Muzzarelli, K.M., primary, Kuiper, B.D., additional, Spellmon, N.S., additional, Hackett, J., additional, Brunzelle, J.S., additional, Kovari, I.A., additional, Amblard, F., additional, Yang, Z., additional, Schinazi, R.F., additional, and Kovari, L.C., additional

Published
2018
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23. An agent-based model of avascular tumor growth

Author

Ponce Bobadilla, AV, Doursat, R, and Amblard, F

Abstract

We propose a simplified agent-based model of avascularized tumor. It involves a tissue in which blood vessels introduce nutrients that diffuse. Cells move, proliferate and die according to an individual quantity of “energy” and free space for their offspring. They can transition to a “cancerous” type and an intermediate “mutated” type, where they behave normally but can be affected by cancerous neighbors. We are interested in finding the key parameters that can lead a majority of cancerous cells to be replaced by normal ones. First, we give a brief overview of previous tumor growth models, especially in avascular tissues. Then, we describe in detail the agents and rules of our model, commenting on the choices made. Next, we conduct a parameter space exploration, varying in particular the influence of neighbors, the division probability and mutation probability. Results show a marked phase transition between domains of high cancerous cell density and high mutated cell density. We also analyze the importance of certain rules in our model by “rule knockout” and find that energy-dependency of division and space for offspring are essential, while type-specific division probabilities are not. Finally, we discuss the overall relevance of the model and possible future improvements.

Published
2015

24. Trust and Understanding in Face-to-Face and Synchronous Online Negotiations

Author

van der Toorn, Yvonne, van der Wijst, Per, Damen, Debby, van Amelsvoort, Marije, Zaraté, P., Camilleri, G., Kamissoko, D., Amblard, F., and Language, Communication and Cognition

Subjects
understanding, Synchronicity, Face-to-Face, Online, Trust, Negotiation
Abstract

This study investigates to what extent the synchronous character of chat communication overcomes the problems in creating mutual understanding and trust between conflicting parties. An experimental study was conducted in which participants negotiated with a confederate in either a face-to-face or online setting. The results show that negotiators feel equally understood and trusted by the other party in both conditions. However, their own ideas about understanding and trusting the other party are higher after a FtF negotiation than after an online negotiation.

Published
2014

25. Circular Questions, Trust and Understanding in Mediations

Author

Damen, Debby, van der Wijst, Per, van der Toorn, Yvonne, van Amelsvoort, Marije, Zaraté, P., Camilleri, G., Kamissoko, D., Amblard, F., and Language, Communication and Cognition

Subjects
understanding, perspective-taking, Mediation, circular questions, Trust
Abstract

This research addresses the question whether a relation-enhancing communication technique - circular questioning - influences the establishment of mutual understanding and interpersonal trust in mediation settings. A circular question obliges the addressee to take the perspective of the other disputant in the conflict. This question was studied in an experimental setting in which disputants had to solve a conflict by the help of a professional mediator, who either used circular questions or open (i.e., linear) questions. It was expected that mediations in which circular questions were used led to a higher level of mutual understanding and interpersonal trust between disputants and, ultimately, to a better outcome. The first results of the study show, however, that the questioning style of the mediator did not influence disputants' perceived mutual understanding, nor the interpersonal trust they experienced afterwards. The satisfaction with the outcome increased with a higher level of mutual understanding and interpersonal trust in their counterpart. We discuss the effects of the questioning style of the mediator and conclude with reflections on reasons why these effects did not lead to differences in mutual understanding and trust between the disputants.

Published
2014

26. OA4-5 LB SIV persistence in ART-treated infant rhesus macaques

Author

Mavigner, M., primary, Deleage, C., additional, Habib, J., additional, Rosen, E., additional, Kashuba, A., additional, Amblard, F., additional, Schinazi, R., additional, Geleziunas, R., additional, Hesselgesser, J., additional, Li, B., additional, Hattersley, J., additional, McGary, C., additional, Paiardini, M., additional, Wood, M., additional, Sodora, D., additional, Silvestri, G., additional, Estes, J., additional, and Chahroudi, A., additional

Published
2016
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29. Assessing the influence of incentives networks on land use/cover changes: a social an spatial agent-based simulation approach

Author

Caillault, Sébastien, Delmotte, S., Kêdowidé, C., Mialhe, F., Vannier, C., Amblard, F., Bécu, N., Gautreau, P., Etienne, Maxime, Houet, T., Espaces et Sociétés (ESO), Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université d'Angers (UA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Le Mans Université (UM), MAD ENVIRONNEMENT MODELING AND ANALYSIS OF DATA IN ENVIRONMENT GRADIGNAN FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Centre National d'Études Spatiales [Toulouse] (CNES), Littoral, Environnement, Télédétection, Géomatique (LETG - Rennes), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Le Mans Université (UM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-AGROCAMPUS OUEST-Université de Rennes 2 (UR2), and MAD-Environnement

Subjects
[SHS]Humanities and Social Sciences
Published
2010

30. Editorial

Author

Amblard, F., Jager, W., and Marketing

Published
2008

32. Modeling and Simulation Dictionary - English-French-Turkish

Author

Oren T.I., Lucile Torres, Amblard F., P, Belaud J., Jean Caussanel, Dalle O., Duboz R., Alain Ferrarini, Claudia Frydman, Maâmar Hamri, Hill D., Aziz Naamane, Siron P., Erwan Tranvouez, Gregory Zacharewicz, Laboratoire des Sciences de l'Information et des Systèmes (LSIS), Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Université de Toulon (UTLN)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Arts et Métiers Paristech ENSAM Aix-en-Provence-Centre National de la Recherche Scientifique (CNRS), and Domingues Vinhas, William

Subjects
[INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, [INFO]Computer Science [cs], [INFO] Computer Science [cs], [INFO.INFO-AU] Computer Science [cs]/Automatic Control Engineering, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

ISBN 2―9524747-0―2; National audience; no abstract

Published
2006

35. MDA compliant Design of SimExplorer, A Software to handle simulation experimental frameworks

Author

Amblard, F., Hill, David R.C., Bernard, Samuel, Truffot, J., Deffuant, G., Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and DOREAU, Bastien

Subjects
[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Published
2003

36. How a conceptual framework can help to design models following decreasing abstraction

Author

Amblard, F., Ferrand, N., Hill, David R.C., DOREAU, Bastien, Laboratoire d'ingénierie pour les systèmes complexes (UR LISC), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Irstea Publications, Migration, Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
[SDE] Environmental Sciences, CEMAGREF, LISC, LIMOS, [SDE]Environmental Sciences, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, DAMMASS
Abstract

In this paper we propose a framework, named DAMMASS, standing for Decreasing Abstraction Methodology for Multi-Agent Social Ssimulation, elabored for the design and the implementation of individual-based social models. Its main Characteristics is modularity. It recovers two major features. The first feature is the modularity of the modelling process : following the decreasing abstraction methology usus a collection of models growing from very simple and abstract models to more complex and realist ones. The second feature deals with the modularity of a given model in the frame of social and ecological modelling, it is described in term of four kinds of sub-models : Agent, Relation, Environment, Oragnization. The implementation of the framework will enable the management of the modelling process as well as the management of each sub-model., Dans ce papier nous proposons un framework, appelé DAMMASS, pour Méthodologie d'Abstraction Décroissante pour la Simulation Sociale Multi-Agent, élaborée pour la conception et l'implémentation de modèles sociaux individus-centrés. Sa principale caractéristique est la modularité. Cela recouvre deux principaux aspects. Le premier est la modularité du processus de modélisation : en suivant une méthodologie d'abstraction décroissante, il utilise une collection de modèles croissants de modèles très simples et très abstraits vers des modèles plus complexex et plus réalistes. Le deuxième aspect concerne la modularité d'un modèle donné dans le cadre de la modélisation sociale et écologique, il est décrit sous la forme de quatre sous-modèles : Agents, Relation, Environnemnt et Organisation. L'implémentation du framework permettra la gestion du processus de mmodélisation aussi bien que la gestion de chacun des sous-modèles.

Published
2001

42. Chimérisme tétragamétique : à propos d’un cas

Author

Loriaux, A., primary, Boulet, S., additional, Delorme, V., additional, Althuser, M., additional, Giroud Lathuile, C., additional, Grego, S., additional, Amblard, F., additional, Dupuis, C., additional, Schaal, J.-P., additional, and Jouk, P.-S., additional

Published
2011
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43. Physical mapping by FISH of the DiGeorge critical region (DGCR): Involvement of the region in familial cases

Author

Desmaze, C., Prieur, M., Amblard, F., Aikem, M., Ledeist, F., Demczuk, S., Jessica zucman-rossi, Plougastel, B., Delattre, O., Croquette, M. -F, Breviere, G. -M, Huon, C., Le Merrer, M., Mathieu, M., Sidi, D., Stephan, J. -L, and Aurias, A.

Subjects
Adult, Male, Chromosomes, Human, Pair 22, Infant, Newborn, Chromosome Mapping, Infant, Original Articles, Hybrid Cells, Cosmids, Translocation, Genetic, Cell Line, Pedigree, Phenotype, Pregnancy, Molecular Probes, DiGeorge Syndrome, Humans, Female, Chromosome Deletion, Child, In Situ Hybridization, Fluorescence
Abstract

We describe the relative ordering, by fluorescence in situ hybridization, of cosmid loci and translocation breakpoints in the DiGeorge syndrome (DGS) critical region of chromosome 22. This physical map enables us to define a large region, commonly deleted in a majority of affected patients, and the smallest deleted region which, when lost, is sufficient to produce DGS. In four instances, a similar large deleted region is observed in a familial context. In these pedigrees, the deletion is encountered in one parent with mild features of the disease.

Published
1993

47. A submicroscopic unbalanced subtelomeric translocation t(2p;10q) identified by fluorescence in situ hybridization: fetus with increased nuchal translucency and normal standard karyotype with later growth and developmental delay, rhombencephalosynapsis (RES)

Author

Lespinasse, J., primary, Testard, H., additional, Nugues, F., additional, Till, M., additional, Cordier, M.P., additional, Althuser, M., additional, Amblard, F., additional, Fert-Ferrer, S., additional, Durand, C., additional, Dalmon, F., additional, Pourcel, C., additional, and Jouk, P.S., additional

Published
2004
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