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Background: Despite enormous attempts to stop the spread of tuberculosis (TB), TB continues to be a major global public health concern. A crucial group for influencing future public health understanding and policies is represented by students. Even though TB is a well-known disease, students’ misunderstandings and knowledge gaps might undermine successful TB control initiatives. This study aimed to identify student’s TB misconceptions and its impact on public health. A comprehensive literature review was conducted to explore researches focused on TB knowledge among students. Common themes from the chosen studies, such as knowledge of TB, its transmission, symptoms, risk factors and preventive methods were examined. We looked at how these information gaps can affect public health measures. The review revealed substantial gaps in students' knowledge of TB. Many students lacked a thorough understanding of TB symptoms, risk factors, and transmission. TB-related myths and stigma were also widely held. There is a need for educational initiatives, given the lack of understanding regarding TB prevention and potential therapies. The impression of tuberculosis (TB) as a past illness rather than a present-day hazard was also noticed, underscoring the demand for a revised public health message. The identified gaps regarding TB among students highlight the necessity of specialized educational efforts. Students can become champions for TB prevention and control by including TB-related issues in educational curriculum, workshops, and awareness campaigns. Wider spread of factual information can be facilitated by utilizing digital platforms and interactive teaching tools.