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18 results on '"Amaral, A. J. R."'

1. Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials

Author

Rosas, Miguel, Sousa, Cristiana F. V., Pereira, Ana, Amaral, Adérito J. R., Pesqueira, Tamagno, Patrício, Sónia G., Fateixa, Sara, Nogueira, Helena I. S., Mano, João F., Oliveira, Ana L., and Borges, João

Abstract

Silk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encompassing SS and oppositely charged chitosan (CHT) through a combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly technology. The successful buildup of SS/CHT multilayered nanobiomaterials was demonstrated by the quartz crystal microbalance with dissipation monitoring and attenuated total reflectance-Fourier transform infrared spectroscopy, and the nanofilms’ wettable properties and nanofibrillar-like topography were shown by water contact angle, atomic force microscopy, and scanning electron microscopy. In vitroassays demonstrated the cytocompatibility of the LbL nanofilms toward human primary dermal fibroblasts, holding great promise as biofunctional nanocoatings for drug/therapeutics/cell delivery, tissue engineering, and regenerative medicine.

Published
2025
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3. The European Polysaccharide Network of Excellence (EPNOE) research roadmap 2040 : Advanced strategies for exploiting the vast potential of polysaccharides as renewable bioresources

Author

Gericke, M., Amaral, A. J. R., Budtova, T., De Wever, P., Groth, T., Heinze, T., Höfte, H., Huber, A., Ikkala, O., Kapuśniak, J., Kargl, R., Mano, J. F., Másson, M., Matricardi, P., Medronho, B., Norgren, Magnus, Nypelö, T., Nyström, L., Roig, A., Sauer, M., Schols, H. A., van der Linden, J., Wrodnigg, T. M., Xu, C., Yakubov, G. E., Stana Kleinschek, K., Fardim, P., Gericke, M., Amaral, A. J. R., Budtova, T., De Wever, P., Groth, T., Heinze, T., Höfte, H., Huber, A., Ikkala, O., Kapuśniak, J., Kargl, R., Mano, J. F., Másson, M., Matricardi, P., Medronho, B., Norgren, Magnus, Nypelö, T., Nyström, L., Roig, A., Sauer, M., Schols, H. A., van der Linden, J., Wrodnigg, T. M., Xu, C., Yakubov, G. E., Stana Kleinschek, K., and Fardim, P.

Abstract

Polysaccharides are among the most abundant bioresources on earth and consequently need to play a pivotal role when addressing existential scientific challenges like climate change and the shift from fossil-based to sustainable biobased materials. The Research Roadmap 2040 of the European Polysaccharide Network of Excellence (EPNOE) provides an expert's view on how future research and development strategies need to evolve to fully exploit the vast potential of polysaccharides as renewable bioresources. It is addressed to academic researchers, companies, as well as policymakers and covers five strategic areas that are of great importance in the context of polysaccharide related research: (I) Materials & Engineering, (II) Food & Nutrition, (III) Biomedical Applications, (IV) Chemistry, Biology & Physics, and (V) Skills & Education. Each section summarizes the state of research, identifies challenges that are currently faced, project achievements and developments that are expected in the upcoming 20 years, and finally provides outlines on how future research activities need to evolve.

Published
2024
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4. The European Polysaccharide Network of Excellence (EPNOE) research roadmap 2040: Advanced strategies for exploiting the vast potential of polysaccharides as renewable bioresources

Author

European Polysaccharide Network of Excellence, Agencia Estatal de Investigación (España), Gericke, Martin, Amaral, Adérito J. R., Budtova, Tatiana, Wever, Pieter De, Groth, Thomas, Heinze, Thomas, Höfte, Herman, Huber, Anton, Ikkala, Olli, Kapuśniak, Janusz, Kargl, Rupert, Mano, João F., Másson, Már, Matricardi, Pietro, Medronho, Bruno, Norgren, Magnus, Nypelö, Tiina, Nyström, Laura, Roig Serra, Anna, Sauer, Michael, Schols, Henk A., Linden, John van der, Wrodnigg, Tanja M., Xu, Chunlin, Yakubov, Gleb E., Stana Kleinschek, Karin, European Polysaccharide Network of Excellence, Agencia Estatal de Investigación (España), Gericke, Martin, Amaral, Adérito J. R., Budtova, Tatiana, Wever, Pieter De, Groth, Thomas, Heinze, Thomas, Höfte, Herman, Huber, Anton, Ikkala, Olli, Kapuśniak, Janusz, Kargl, Rupert, Mano, João F., Másson, Már, Matricardi, Pietro, Medronho, Bruno, Norgren, Magnus, Nypelö, Tiina, Nyström, Laura, Roig Serra, Anna, Sauer, Michael, Schols, Henk A., Linden, John van der, Wrodnigg, Tanja M., Xu, Chunlin, Yakubov, Gleb E., and Stana Kleinschek, Karin

Abstract

Polysaccharides are among the most abundant bioresources on earth and consequently need to play a pivotal role when addressing existential scientific challenges like climate change and the shift from fossil-based to sustainable biobased materials. The Research Roadmap 2040 of the European Polysaccharide Network of Excellence (EPNOE) provides an expert's view on how future research and development strategies need to evolve to fully exploit the vast potential of polysaccharides as renewable bioresources. It is addressed to academic researchers, companies, as well as policymakers and covers five strategic areas that are of great importance in the context of polysaccharide related research: (I) Materials & Engineering, (II) Food & Nutrition, (III) Biomedical Applications, (IV) Chemistry, Biology & Physics, and (V) Skills & Education. Each section summarizes the state of research, identifies challenges that are currently faced, project achievements and developments that are expected in the upcoming 20 years, and finally provides outlines on how future research activities need to evolve.

Published
2024

8. Self-supporting hyaluronic acid-functionalized G-quadruplex-based perfusable multicomponent hydrogels embedded in photo-cross-linkable matrices for bioapplications

Author

Sousa, Vera, Amaral, Adérito J. R., Castanheira, Edgar J., Marques, Igor, Rodrigues, João M. M., Félix, Vítor, Borges, João, and Mano, João F.

Abstract

Dynamic G-quadruplex supramolecular hydrogels have aroused great interest in a broad range of bioapplications. However, neither the development of native extracellular matrix (ECM)-derived natural biopolymer-functionalized G-quadruplex hydrogels nor their use to create perfusable self-supporting hydrogels has been explored to date, despite their intrinsic potential as carrier vehicles of therapeutic agents, or even living cells in advanced regenerative therapies, or as platforms to enable the diffusion of nutrients and oxygen to sustain long-term cell survival. Herein, we developed a dynamic co-assembling multicomponent system that integrates guanosine (G), 3-aminophenylboronic acid functionalized hyaluronic acid (HA-PBA), and potassium chloride to bioengineer strong, homogeneous, and transparent HA-functionalized G-quadruplex hydrogels with injectable, thermo-reversible, conductive, and self-healing properties. The supramolecular polymeric hydrogels were developed by hydrogen bonding and π-π stacking interactions between G coupled via dynamic covalent boronate ester bonds to HA-PBA and stabilized by K+ ions, as demonstrated by a combination of experiments and molecular dynamics simulations. The intrinsic instability of the self-assembled G-quadruplex structures was used to bioengineer self-supporting perfusable multicomponent hydrogels with interconnected size and shape-tunable hollow microchannels when embedded in 3D methacrylated gelatin supporting matrices. The microchannel-embedded 3D constructs have shown enhanced cell viability when compared to the bulk hydrogels, holding great promise for being use as artificial vessels for enabling the diffusion of nutrients and oxygen essential for cell survival. The proposed approach opens new avenues on the use of ECM-derived natural biopolymer-functionalized dynamic G-quadruplex hydrogels to design next-generation smart systems for being used in tissue regeneration, drug screening, or organ-on-a-chip. published

Published
2023

17. ChemInform Abstract: Synthesis of Bifunctional Cyclic Carbonates from CO2 Catalyzed by Choline-Based Systems.

Author

Amaral, Aderito J. R., Coelho, Jorge F. J., and Serra, Armenio C.

Subjects
*CARBONATE synthesis, *BIFUNCTIONAL catalysis, *CARBON dioxide, *CHOLINE, *CARBOXYLATION, *ORGANOCATALYSIS
Abstract

Easily prepared choline iodide is an active catalyst for the synthesis of cyclic carbonates through the coupling reaction of carbon dioxide and epoxides. [ABSTRACT FROM AUTHOR]

Published
2014
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