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1. Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Author

Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert Barsotti, Lindon H. Young, and Qian Chen

Subjects
Doxorubicin, Cardiotoxicity, Mitochondrial-targeted antioxidants, Vitamin C, Oxidative stress, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270
Abstract

Abstract Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. Methods We investigated the dose-response relationship of MitoQ, SKQ1, and vitamin C on Dox-induced damage on H9c2 cardiomyoblasts when drugs were given concurrently with Dox (e.g., co-treatment) or 24 h prior to Dox (e.g., pretreatment). Moreover, their effects on intracellular and mitochondrial oxidative stress were evaluated by 2,7-dichlorofluorescin diacetate and MitoSOX, respectively. Results Dox (0.5–50 μM, n = 6) dose-dependently reduced cell viability. By contrast, co-treatment of MitoQ (0.05–10 μM, n = 6) and SKQ1 (0.05–10 μM, n = 6), but not vitamin C (1–2000 μM, n = 3), significantly improved cell viability only at intermediate doses (0.5–1 μM). MitoQ (1 μM) and SKQ1 (1 μM) significantly increased cell viability to 1.79 ± 0.12 and 1.59 ± 0.08 relative to Dox alone, respectively (both p

Published
2021
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2. Brk/PTK6 and Involucrin Expression May Predict Breast Cancer Cell Responses to Vitamin D3

Author

Carol Box, Caroline Pennington, Stephen Hare, Sarah Porter, Dylan Edwards, Suzanne Eccles, Mark Crompton, and Amanda Harvey

Subjects
1,25-dihydroxyvitamin D3, breast cancer, breast tumour kinase (Brk), protein tyrosine kinase 6 (PTK6), differentiation, involucrin, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The process of human embryonic mammary development gives rise to the structures in which mammary cells share a developmental lineage with skin epithelial cells such as keratinocytes. As some breast carcinomas have previously been shown to express high levels of involucrin, a marker of keratinocyte differentiation, we hypothesised that some breast tumours may de-differentiate to a keratinocyte-derived ‘evolutionary history’. To confirm our hypothesis, we investigated the frequency of involucrin expression along with that of Brk, a tyrosine kinase expressed in up to 86% of breast carcinomas whose normal expression patterns are restricted to differentiating epithelial cells, most notably those in the skin (keratinocytes) and the gastrointestinal tract. We found that involucrin, a keratinocyte differentiation marker, was expressed in a high proportion (78%) of breast carcinoma samples and cell lines. Interestingly, tumour samples found to express high levels of involucrin were also shown to express Brk. 1,25-dihydroxyvitamin D3, a known differentiation agent and potential anti-cancer agent, decreased proliferation in the breast cancer cell lines that expressed both involucrin and Brk, whereas the Brk/involucrin negative cell lines tested were less susceptible. In addition, responses to 1,25-dihydroxyvitamin D3 were not correlated with vitamin D receptor expression. These data contribute to the growing body of evidence suggesting that cellular responses to 1,25-dihydroxyvitamin D3 are potentially independent of vitamin D receptor status and provide an insight into potential markers, such as Brk and/or involucrin that could predict therapeutic responses to 1,25-dihydroxyvitamin D3.

Published
2023
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4. Rapid sample preparation with Lyse-It® for Listeria monocytogenes and Vibrio cholerae.

Author

Tonya M Santaus, Shan Li, Paula Ladd, Amanda Harvey, Shannon Cole, O Colin Stine, and Chris D Geddes

Subjects
Medicine, Science
Abstract

Sample preparation is a leading bottleneck in rapid detection of pathogenic bacteria. Here, we use Lyse-It® for bacterial cellular lysis, genomic DNA fragmentation, and protein release and degradation for both Listeria monocytogenes and Vibrio cholerae. The concept of Lyse-It® employs a conventional microwave and Lyse-It® slides for intensely focused microwave irradiation onto the sample. High microwave power and a

Published
2018
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6. Metal-Enhanced Photosensitization of Singlet Oxygen (ME1O2) from Brominated Carbon Nanodots on Silver Nanoparticle Substrates

Author

Chris D. Geddes, Amanda Harvey, and Rachael Knoblauch

Subjects
chemistry.chemical_classification, Reactive oxygen species, Plasmonic nanoparticles, Singlet oxygen, Biophysics, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, Biochemistry, Oxygen, Fluorescence, Small molecule, Silver nanoparticle, 010309 optics, chemistry.chemical_compound, chemistry, 0103 physical sciences, Nanodot, 0210 nano-technology, Biotechnology
Abstract

The deleterious effects of reactive oxygen species (ROS), including singlet oxygen (1O2), on biological systems have cultivated widespread interest in fields ranging from therapeutic techniques to sterilization materials. Researchers have, for example, sought to capitalize on the oxidative damage from singlet oxygen to treat tumors as well as to kill antibiotic resistant bacteria. To generate 1O2 in a controllable manner, photosensitizers are optimized to generate 1O2 from ground state oxygen (3O2) when excited by light. When considering applications of photosensitization, favorable properties include high 1O2 yield, low synthetic complexity, and minimal cost. Previously, studies have shown that plasmonic nanoparticles are able to amplify the photosensitization of 1O2 from small molecule photosensitizers in a mechanism similar to metal-enhanced fluorescence (MEF), thereby improving yield. A recent study from our lab has demonstrated that brominated carbon nanodots, which are an inexpensive and simple-to-collect as a hydrocarbon combustion byproduct, generate reactive oxygen species that can be used for antimicrobial photodynamic inactivation of bacteria. Herein we investigate the combination of these advantageous properties. Using the turn-on fluorescent probe Singlet Oxygen Sensor Green™ to detect 1O2, we report the metal-enhanced photosensitization of 1O2 by brominated dots in silvered Quanta Plate™ wells. These results provide a promising direction for the potential optimization of carbon nanodot-based agents in light-activated antimicrobial materials.

Published
2021

7. Antimicrobial carbon nanodots: photodynamic inactivation and dark antimicrobial effects on bacteria by brominated carbon nanodots

Author

Chris D. Geddes, Estelle Ra, Amanda Harvey, Rachael Knoblauch, Judy Lau, Ken M Greenberg, and Elizabeth Hawkins

Subjects
chemistry.chemical_classification, Reactive oxygen species, Photosensitizing Agents, Bacteria, biology, Pathogenic bacteria, medicine.disease_cause, Antimicrobial, biology.organism_classification, Combinatorial chemistry, Carbon, Article, Anti-Bacterial Agents, chemistry.chemical_compound, Antibiotic resistance, Anti-Infective Agents, Photochemotherapy, chemistry, medicine, General Materials Science, Photosensitizer, Nanodot, Reactive nitrogen species
Abstract

The evolving threat of antibiotic resistance development in pathogenic bacteria necessitates the continued cultivation of new technologies and agents to mitigate associated negative health impacts globally. It is no surprise that infection prevention and control are cited by the Centers for Disease Control and Prevention (CDC) as two routes for combating this dangerous trend. One technology that has gained great research interest is antimicrobial photodynamic inactivation of bacteria, or APDI. This technique permits controllable activation of antimicrobial effects by combining specific light excitation with the photodynamic properties of a photosensitizer; when activated, the photosensitizer generates reactive oxygen species (ROS) from molecular oxygen via either a Type I (electron transfer) or Type II (energy transfer) pathway. These species subsequently inflict oxidative damage on nearby bacteria, resulting in suppressed growth and cell death. To date, small molecule photosensitizers have been developed, yet the scalability of these as widespread sterilization agents is limited due to complex and costly synthetic procedures. Herein we report the use of brominated carbon nanodots (BrCND) as new photosensitizers for APDI. These combustion byproducts are easily and inexpensively collected; incorporation of bromine into the nanodot permits photosensitization effects that are not inherent to the carbon nanodot structure alone—a consequence of triplet character gained by the heavy atom effect. BrCND demonstrate both Type I and Type II photosensitization under UV-A irradiation, and furthermore are shown to have significant antimicrobial effects against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and Listeria monocytogenes as well. A mechanism of “dark” toxicity is additionally reported; the pH-triggered release of reactive nitrogen species is detected from a carbon nanodot structure for the first time. The results described present the BrCND structure as a competitive new antimicrobial agent for controllable sterilization of bacteria.

Published
2021

8. Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Author

Sachin Prasad, Rose Martorana, Erin Ross, Catherine Wastella, Robert Barsotti, Halil Onal, Hafsa Ahmad, Lindon H. Young, Adona Pjetergjoka, Amogh Sehgal, Amanda Harvey, Qian Chen, and Brian Sacks

Subjects
Antioxidant, Cardiotonic Agents, Cell Survival, Plastoquinone, Ubiquinone, medicine.medical_treatment, RM1-950, Ascorbic Acid, Pharmacology, medicine.disease_cause, Antioxidants, Drug Administration Schedule, Cell Line, chemistry.chemical_compound, Organophosphorus Compounds, Superoxides, RA1190-1270, medicine, Animals, Pharmacology (medical), Doxorubicin, Drug Interactions, Myocytes, Cardiac, Viability assay, Vitamin C, Cardioprotection, Cardiotoxicity, MitoQ, Antibiotics, Antineoplastic, Chemistry, Mitochondria, Rats, Oxidative stress, Toxicology. Poisons, Mitochondrial-targeted antioxidants, Therapeutics. Pharmacology, medicine.drug, Research Article
Abstract

Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. Methods We investigated the dose-response relationship of MitoQ, SKQ1, and vitamin C on Dox-induced damage on H9c2 cardiomyoblasts when drugs were given concurrently with Dox (e.g., co-treatment) or 24 h prior to Dox (e.g., pretreatment). Moreover, their effects on intracellular and mitochondrial oxidative stress were evaluated by 2,7-dichlorofluorescin diacetate and MitoSOX, respectively. Results Dox (0.5–50 μM, n = 6) dose-dependently reduced cell viability. By contrast, co-treatment of MitoQ (0.05–10 μM, n = 6) and SKQ1 (0.05–10 μM, n = 6), but not vitamin C (1–2000 μM, n = 3), significantly improved cell viability only at intermediate doses (0.5–1 μM). MitoQ (1 μM) and SKQ1 (1 μM) significantly increased cell viability to 1.79 ± 0.12 and 1.59 ± 0.08 relative to Dox alone, respectively (both p n = 9) and SKQ1 (5 μM, n = 7) showed maximal protection and improved cell viability to 2.19 ± 0.13 and 1.65 ± 0.07 relative to Dox alone, respectively (both p Conclusion The data suggest that MitoQ and SKQ1, but not vitamin C, mitigated DOX-induced damage. Moreover, MitoQ pretreatment showed significantly higher cardioprotection than its co-treatment and SKQ1, which may be due to its better antioxidant effects.

Published
2021

9. The Effects of Metformin, Aminoguanidine, and Pyridoxamine on Methylglyoxal Induced Cardiac Myocytes Injury

Author

Qian Chen, Hafsa Ahmed, Robert Barsotti, Julia Colangeli, Dean Delgado, Alisa Kim, Lindon H. Young, Robinderpal Sandu, Rose Martorana, and Amanda Harvey

Subjects
Methylglyoxal, Pharmacology, Biochemistry, Metformin, chemistry.chemical_compound, chemistry, Glycation, Genetics, medicine, Myocyte, Pyridoxamine, Molecular Biology, Biotechnology, medicine.drug
Abstract

In diabetics, formation of advanced glycation end (AGE) products has been closely associated with cardiovascular complications. In order to mitigate the injury caused by AGEs, it is critical to und...

Published
2019

10. An Easier Way to Manage Casefinding

Author

Amanda, Harvey-McKee, Paula, Kepner, Leslie, Porter, and Laura, Vondenhuevel

Subjects
Biomedical Research, Data Collection, Neoplasms, Humans, Registries, United States
Published
2018

11. Lyse-It™: A Rapid Platform for Cellular Lysing and Tunable DNA/Protein Fragmentation

Author

Maraki Y. Negesse, Melissa Cyr, Johan H. Melendez, Tonya M. Santaus, Amanda Harvey, Paula D. Ladd, and Chris D. Geddes

Subjects
0301 basic medicine, Lysis, 030106 microbiology, Biology, Protein degradation, biology.organism_classification, Molecular biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Biochemistry, chemistry, DNA fragmentation, Sample preparation, Fragmentation (cell biology), Intracellular, Bacteria, DNA
Abstract

In this article, we review Lyse-It™; a method for the low cost, efficient, and rapid sample preparation of various bacteria and cell types. Currently, bacterial detection and identification is underpinned by two discreet processes, namely genomic isolation followed by its identification. While molecular detection strategies are available to detect DNA and proteins in time-frames ranging for minutes to hours, the bottleneck in all of these detection strategies lies in the initial sample preparation, i.e. in the cellular lysing, which can add several hours or more to the overall bacterial identification process. For intercellular components, such as DNA and proteins, there is typically a two-step process of breaking open cells (lysis) and then fragmenting the released DNA or degrading the proteins. Cellular lysing is typically a multi-step, multi-reagent process that is tedious, expensive, and time-consuming. Following cell lysis, the DNA and/or proteins must be extracted and purified before downstream analysis.

Published
2017

12. An examination of school- and student-level characteristics associated with the likelihood of students' meeting the Canadian physical activity guidelines in the COMPASS study

Author

Amanda Harvey, Guy Faulkner, Scott T. Leatherdale, and Lora Giangregorio

Subjects
Gerontology, Male, medicine.medical_specialty, Canada, Adolescent, Physical fitness, education, Physical activity, Binge drinking, 030209 endocrinology & metabolism, Guidelines as Topic, Level design, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, Exercise physiology, Students, Exercise, Schools, business.industry, Public health, Public Health, Environmental and Occupational Health, General Medicine, Guideline, Cross-Sectional Studies, Female, Guideline Adherence, Quantitative Research, business, Body mass index
Abstract

OBJECTIVES: To examine school- and student-level correlates of physical activity. METHODS: Cross-sectional Year 2 data collected from 45 298 grade 9–12 students attending 89 secondary schools in the COMPASS study were examined using multi-level modelling to predict the likelihood of students a) achieving 60 minutes of moderate to vigorous physical activity (MVPA) daily; and b) achieving the Canadian Society for Exercise Physiology (CSEP) activity guideline for youth (60 minutes/MVPA daily, vigorous physical activity at least three days in a week, and resistance training at least three days in a week). RESULTS: The prevalence of students achieving 60 minutes of MVPA daily and meeting the CSEP guideline was 49.3% and 31.0% respectively. Modest between-school variability was identified (1.1% for 60 minutes MVPA and 0.8% for CSEP guideline). School-level characteristics significantly associated with the outcome measures included location, school size, quality of facilities, and accessibility of facilities. Significant student-level correlates included sex, grade, weekly income, binge drinking, fruit and vegetable consumption, and body mass index. CONCLUSIONS: Most youth in this large study reported inadequate physical activity levels. Students were more likely to achieve 60 minutes of MVPA if they attended a larger school or a school in an urban location, whereas students were less likely to meet the CSEP guideline if they attended a school in a small urban location. However, student-level factors, such as binge drinking and inadequate fruit and vegetable consumption, were more strongly associated with the outcomes examined.

Published
2016

13. Inactivation of Bacillus anthracis Spores during Laboratory-Scale Composting of Feedlot Cattle Manure

Author

Amanda Harvey, Tim Reuter, Kingsley K. Amoako, Kim Stanford, Shanwei Xu, Tim A. McAllister, L. B. Selinger, and Ruth Barbieri

Subjects
0301 basic medicine, Microbiology (medical), Veterinary medicine, compost, sporulation, Feedlot cattle, 030106 microbiology, lcsh:QR1-502, Laboratory scale, engineering.material, spore, complex mixtures, Microbiology, lcsh:Microbiology, 03 medical and health sciences, Health implications, Original Research, biology, Compost, fungi, Outbreak, anthrax, temperature, biology.organism_classification, Manure, Spore, Bacillus anthracis, 030104 developmental biology, engineering
Abstract

Anthrax outbreaks in livestock have social, economic and health implications, altering farmer’s livelihoods, impacting trade and posing a zoonotic risk. Our study investigated the survival of B. thuringiensis and B. anthracis spores sporulated at 15ºC, 20ºC or 37ºC, over 33 days of composting. Spores (~7.5 log10 CFU g-1) were mixed with manure and composted in laboratory scale composters. After 15 days, the compost was mixed and returned to the composter for a second cycle. Temperatures peaked at 71°C on day 2 and remained ≥55°C for an average of 7 days in the first cycle, but did not exceed 55°C in the second. For B. thuringiensis, spores generated at 15°C and 21°C exhibited reduced (P < 0.05) viability of 2.7 and 2.6 log10 CFU g-1 respectively, as compared to a 0.6 log10 CFU g-1 reduction for those generated at 37°C. For B. anthracis, sporulation temperature did not impact spore survival as there was a 2.5, 2.2 and 2.8 log10 CFU g-1 reduction after composting for spores generated at 15°C, 21°C and 37°C, respectively. For both species, spore viability declined more rapidly (P < 0.05) in the first as compared to the second composting cycle. Our findings suggest that the duration of thermophilic exposure (≥55°C) is the main factor influencing survival of B. anthracis spores in compost. As sporulation temperature did not influence survival of B. anthracis, composting may lower the viability of spores associated with carcasses infected with B. anthracis over a range of sporulation temperatures.

Published
2016
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14. Protein Tyrosine Kinase-6 (PTK6)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2016

15. Health Care Providers’ Perspectives of an Intervention Designed to Improve Colorectal Cancer Screening Rates in Family Medicine Residency Clinics

Author

Geoffrey Goldsmith, Audrey J. Brooks, Amanda Harvey, Robert Price, and Sara Rowe

Subjects
medicine.medical_specialty, Attitude of Health Personnel, Health Personnel, media_common.quotation_subject, Psychological intervention, Nursing, Surveys and Questionnaires, Intervention (counseling), Cancer screening, Health care, Humans, Medicine, Practice Patterns, Physicians', Early Detection of Cancer, Qualitative Research, media_common, Teamwork, Cancer prevention, business.industry, Public Health, Environmental and Occupational Health, Internship and Residency, Focus Groups, Focus group, Oncology, Content analysis, Family medicine, Patient Compliance, Colorectal Neoplasms, Family Practice, business
Abstract

The purpose of this study was to obtain feedback from family medicine residents and clinic nurses regarding a colorectal cancer screening (CRCS) intervention. Focus groups were used to ask participants three questions about their perceptions of the intervention and subsequent patient screening behaviors. Content analysis and constant comparison were used to yield two meaningful themes from the participant responses: patient-specific issues and study design issues. Patient-specific issues included: lack of education and fear, finances and insurance coverage, and compliance. Study design issues included: lack of time, a need for reminders to discuss CRCS with patients, quality of the nurse's role, and a need for better clinical staff education and awareness. Results show ways to significantly improve future implementation of the CRCS intervention. Ultimately, future use of clinic-based CRCS interventions could be vastly improved by utilizing strategies to promote teamwork and increase the sense of mutual ownership among clinic staff.

Published
2012

16. Cancer Cell Signalling

Author

Amanda Harvey and Amanda Harvey

Subjects
Cancer invasiveness, Cellular signal transduction, Carcinogenesis, Metastasis, Protein kinases
Abstract

A focused, accessible introduction to this key aspect of cancer biology. It covers the individual cell signalling pathways that are known to be involved in cancer development, and, most important, includes the cross- interactions between the pathways together with the current therapeutic approaches. This is a ‘must-have'for advanced undergraduate and postgraduate students studying and researching within the field of cancer biology.

Published
2013

17. Examining communication- and media-based recreational sedentary behaviors among Canadian youth: results from the COMPASS study

Author

Amanda Harvey and Scott T. Leatherdale

Subjects
Male, medicine.medical_specialty, Canada, Time Factors, Adolescent, Epidemiology, Substance-Related Disorders, Health Behavior, Ethnic group, Guidelines as Topic, Motor Activity, Cohort Studies, Screen time, Age Distribution, Risk-Taking, Surveys and Questionnaires, medicine, Prevalence, Humans, Obesity, Sex Distribution, Recreation, Weight status, Internet, business.industry, Communications Media, Public Health, Environmental and Occupational Health, Risk behavior, Sedentary behavior, medicine.disease, Diet, Video Games, Physical therapy, Female, Television, Substance use, Sedentary Behavior, business, Cell Phone, Demography
Abstract

Objectives To examine the prevalence of different communication- and media-based sedentary behaviors and examine how they are associated with modifiable risk behaviors and key demographic correlates among a large sample of youth. Methods Data from 23,031 grade 9 to grade 12 students in Year 1 (2012–2013) of the COMPASS study (Canada) were used to examine the prevalence of sedentary behaviors by gender and by grade. The between-school variance in sedentary behaviors was calculated and models were developed to examine how modifiable risk factors and demographic correlates were associated with sedentary behaviors. Results Youth averaged 494 (± 313) min/day of sedentary behavior and 96.7% of the sample exceeded the sedentary behavior guidelines of no more than 2 h per day. Significant between-school random variation in the sedentary behaviors was identified. Substance use, weight status, ethnicity, and gender were the main predictors of the sedentary behaviors examined. Conclusions The vast majority of youth in the COMPASS sample are considered highly sedentary. The evidence clearly suggests we need to develop more effective methods of intervening, that school-based programming is warranted, and that gender-specific programming may be required.

Published
2014

18. The non-random repositioning of whole chromosomes and individual gene loci in interphase nuclei and its relevance in disease, infection, aging, and cancer

Author

Joanna M, Bridger, Halime D, Arican-Gotkas, Helen A, Foster, Lauren S, Godwin, Amanda, Harvey, Ian R, Kill, Matty, Knight, Ishita S, Mehta, and Mai Hassan, Ahmed

Subjects
Cell Nucleus, Aging, Neoplasms, Mutation, Chromosomes, Human, Humans, Infections, Lamin Type A, Interphase
Abstract

The genomes of a wide range of different organisms are non-randomly organized within interphase nuclei. Chromosomes and genes can be moved rapidly, with direction, to new non-random locations within nuclei upon a stimulus such as a signal to initiate differentiation, quiescence or senescence, or also the application of heat or an infection with a pathogen. It is now becoming increasingly obvious that chromosome and gene position can be altered in diseases such as cancer and other syndromes that are affected by changes to nuclear architecture such as the laminopathies. This repositioning seems to affect gene expression in these cells and may play a role in progression of the disease. We have some evidence in breast cancer cells and in the premature aging disease Hutchinson-Gilford Progeria that an aberrant nuclear envelope may lead to genome repositioning and correction of these nuclear envelope defects can restore proper gene positioning and expression in both disease situations.Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply involved in regulating specific sets of genes. A deviation from normal spatial positioning of the genome for a particular cell type could lead to changes that affect the future health of the cell or even an individual.

Published
2014

20. p120 RasGAP

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

21. PCD8 (Programmed Cell Death 8)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

22. p38MAPKK

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

23. Protein Kinase Interferon-Induced Double-Stranded RNA-Activated (PRKR)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

24. Phosphatidylinositol 5-phosphate 4-kinase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

25. Phospholipase D

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

26. Prn-i

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

27. p38 MAPK Family of Signal Transduction Proteins

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

28. Pim-1

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

29. Prostate Specific G-Protein-Coupled Receptor

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

30. p42/p44 MAPK

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

31. Protein Farnesyltransferase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

32. Phosphatidylinositol 3,4,5-Trisphosphate-Dependent RAC Exchanger 2

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

33. PLEKHO1 (Pleckstrin-Homology Domain Containing, Family O Member 1)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

34. Phosphatidylinositol (3,4,5)-Trisphosphate-Dependent Rac Exchanger

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

35. P/Q-Type

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

36. Prion Protein

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

37. PtdIns(5)P 4-Kinase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

38. PKS2 (Presumably for Kinase Sequence)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

39. Plasma Membrane Ca2+ ATPase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

40. Palmitoylating Enzyme

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

41. Phosphatidylinositol 3-Kinase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

42. Protein Phosphatase 1 DARPP-32 Inhibitor Protein

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

43. PHLDA1 (Pleckstrin Homology-like Domain, Family A, Member): Alias: PHRIP; TDAG51; DT1P1B11; MGC131738

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

44. PRAP (Pyk2/RAFTK-Associated Protein)

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

45. PtdIns(3,4,5)-Dependent Rac Exchanger 2

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

46. PCAF Lysine Acetyltransferase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

47. Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

48. Provirus Insertion Site of Moloney Murine Leukemia Virus 1 Pim-1

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

49. PIP Kinase

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

50. Proliferation-Inducing Gene 17

Author

Dominique M. Donato, Steven K. Hanks, Kenneth A. Jacobson, M. P. Suresh Jayasekara, Zhan-Guo Gao, Francesca Deflorian, John Papaconstantinou, Ching-Chyuan Hsieh, James H. DeFord, Krassimira Alexieva-Botcheva, Carl W. Anderson, Sheng-Wei Yang, Yuan-Hao Hsu, Linya You, Xiang-Jiao Yang, Miles D. Houslay, Joanna E. Gawecka, Joe W. Ramos, Maria Aparecida Nagai, Jonathan H. Clarke, Robin F. Irvine, Su Jun Lim, Willis X. Li, Sujeet Kumar, Ponniah Selvakumar, Rajendra K. Sharma, Takashi Sasaki, Jun Kotera, Kenji Omori, Lomon So, David A. Fruman, Makoto Murakami, Julian Gomez-Cambronero, Karen M. Henkels, Christopher T. Cottage, Balaji Sundararaman, Shabana Din, Nirmala Hariharan, Mark A. Sussman, Dana Onica, David W. Litchfield, Peter Storz, Anthony John Sadler, Emanuel E. Strehler, Daryl L. Goad, Michael A. Grillo, Peter Koulen, Hisashi Tatebe, Kazuhiro Shiozaki, Giorgio Iotti, Francesco Blasi, Daisuke Urano, Hiroshi Itoh, Rafael Linden, Vilma R. Martins, Marco A. M. Prado, Lai N. Chan, Fuyuhiko Tamanoi, Amanda Harvey, Mingyao Liu, Melissa Rodriguez, Nicholas R. Leslie, Laura Spinelli, Georgios Zilidis, Nimmi R. Weerasinghe, Priyanka Tibarewal, Laura M. Westrate, Jeffrey P. MacKeigan, Ari Elson, Liat Rousso-Noori, Timothy J. Bauler, Philip D. King, Marina Tiemi Shio, and Martin Olivier

Published
2012

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