Search

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the United States, and the incidence of early-onset CRC (EOCRC,50 years old) has been steadily increasing over the past 30 years. This article provides a comprehensive review of EOCRC traits, including incidence rates and patterns, tumor biologic differences compared to late-onset CRC, dietary risk factors, relationship between CRC and the microbiome, and patient survival outcomes associated with EOCRC. These factors carry importance in determining diagnostic, prognostic, disease monitoring, and treatment planning practices for EOCRC in the future. They also serve as guides for optimizing CRC screening recommendations.

The study of quantum phase transitions that are not clearly associated with broken symmetry is a major effort in condensed matter physics, particularly in regard to the problem of high-temperature superconductivity, for which such transitions are thought to underlie the mechanism of superconductivity itself. Here we argue that the putative quantum critical point in the prototypical unconventional superconductor CeCoIn5 is characterized by the delocalization of electrons in a transition that connects two Fermi surfaces of different volumes, with no apparent broken symmetry. Drawing on established theory of f-electron metals, we discuss an interpretation for such a transition that involves the fractionalization of spin and charge, a model that effectively describes the anomalous transport behavior we measured for the Hall effect.

The study of quantum phase transitions that are not clearly associated with broken symmetry is a major effort in condensed matter physics, particularly in regard to the problem of high-temperature superconductivity, for which such transitions are thought to underlie the mechanism of superconductivity itself. Here we argue that the putative quantum critical point in the prototypical unconventional superconductor CeCoIn