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1. A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author

David de Gonzalo-Calvo, Marta Molinero, Iván D. Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C. García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Anna Moncusí-Moix, Ángel Estella, Luis Tamayo Lomas, Amalia Martínez de la Gándara, Lorenzo Socias, Yhivian Peñasco, Maria Del Carmen de la Torre, Elena Bustamante-Munguira, Elena Gallego Curto, Ignacio Martínez Varela, María Cruz Martin Delgado, Pablo Vidal-Cortés, Juan López Messa, Felipe Pérez-García, Jesús Caballero, José M. Añón, Ana Loza-Vázquez, Nieves Carbonell, Judith Marin-Corral, Ruth Noemí Jorge García, Carmen Barberà, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Jose Ángel Lorente-Balanza, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Antoni Torres, and Ferran Barbé

Subjects
Biomarker, COVID-19, ICU, microRNA, Prognosis, SARS-CoV-2, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. Methods This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group. Results Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR

Published
2023
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2. Analysis and Correction of the Additive Phase Effect Generated by Power Change in a Mach–Zehnder Interferometer Integrated to an Optical Trap

Author

Azael D. Domínguez-Flores, Juan A. Rayas, Amalia Martínez-García, and Raúl R. Cordero

Subjects
optical metrology, microscopy, interferometry, optical trap, immersion oil, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Immersion microscope objectives stand out for their large numerical aperture, which improves the optical resolution of imaging systems such as those used in microscopic interferometry. These objectives increase the gradient forces of a beam focused through them, forming an Optical Trap (OT). However, many studies on microscopic interferometry neglect the contributions of different optical materials in the system that are also exposed to laser radiation, perhaps simply assuming transparency. In this work, a Mach–Zehnder interferometer and an OT, which share several components (including the same oil immersion objective), were coupled. Here, the response of the interferometer to a progressive increase in the OT laser power, while the interferometer laser power remains constant, is reported. Changes in laser power affect the oil temperature, altering its refractive index and volume, which in turn causes a phase shifting on the transmitted wavefront. Optical phase analysis is applied in the three-dimensional measurement of the damage produced by the OT on a paint film. This study suggests that the refractive index variations in the immersion oil affect interferograms because they will then exhibit an additive phase term that must be considered in that final measurement. Additionally, the OT geometry changes with the power increase.

Published
2024
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3. Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

Author

Asier Fernández-Pato, Ana Virseda-Berdices, Salvador Resino, Pablo Ryan, Oscar Martínez-González, Felipe Peréz-García, María Martin-Vicente, Daniel Valle-Millares, Oscar Brochado-Kith, Rafael Blancas, Amalia Martínez, Francisco C. Ceballos, Sofía Bartolome-Sánchez, Erick Joan Vidal-Alcántara, David Alonso, Natalia Blanca-López, Ignacio Ramirez Martinez-Acitores, Laura Martin-Pedraza, María Ángeles Jiménez-Sousa, and Amanda Fernández-Rodríguez

Subjects
sars-cov2, covid-19, mirnas, severity, mortality, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Background MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. Methods and results Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio=4.60; p-value

Published
2022
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4. The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author

Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, and CIBERESUCICOVID Project (COV20/00110, ISCIII)

Subjects
Ventilatory ratio, Mechanical ventilation, COVID-19, SARS-CoV-2, Coronavirus, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0–171.2] to 180.0 [135.4–227.9] mmHg and the ventilatory ratio from 1.73 [1.33–2.25] to 1.96 [1.61–2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01–1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01–1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93–1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.

Published
2021
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5. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Iván D. Benítez, Jordi de Batlle, Gerard Torres, Jessica González, David de Gonzalo-Calvo, Adriano D.S. Targa, Clara Gort-Paniello, Anna Moncusí-Moix, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Anna Motos, Oscar Peñuelas, Jordi Riera, Jesús F. Bermejo-Martin, Yhivian Peñasco, Pilar Ricart, María Cruz Martin Delgado, Luciano Aguilera, Alejandro Rodríguez, Maria Victoria Boado Varela, Fernando Suarez-Sipmann, Juan Carlos Pozo-Laderas, Jordi Solé-Violan, Maite Nieto, Mariana Andrea Novo, José Barberán, Rosario Amaya Villar, José Garnacho-Montero, Jose Luis García-Garmendia, José M. Gómez, José Ángel Lorente, Aaron Blandino Ortiz, Luis Tamayo Lomas, Esther López-Ramos, Alejandro Úbeda, Mercedes Catalán-González, Angel Sánchez-Miralles, Ignacio Martínez Varela, Ruth Noemí Jorge García, Nieves Franco, Víctor D. Gumucio-Sanguino, Arturo Huerta Garcia, Elena Bustamante-Munguira, Luis Jorge Valdivia, Jesús Caballero, Elena Gallego, Amalia Martínez de la Gándara, Álvaro Castellanos-Ortega, Josep Trenado, Judith Marin-Corral, Guillermo M Albaiceta, Maria del Carmen de la Torre, Ana Loza-Vázquez, Pablo Vidal, Juan Lopez Messa, Jose M. Añón, Cristina Carbajales Pérez, Victor Sagredo, Neus Bofill, Nieves Carbonell, Lorenzo Socias, Carme Barberà, Angel Estella, Manuel Valledor Mendez, Emili Diaz, Ana López Lago, Antoni Torres, and Ferran Barbé

Subjects
COVID-19, Critical Care, Prognosis, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae. Methods: Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months. Findings: Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p

Published
2022
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6. La tuberculosis osteoarticular no axial en la edad pediátrica

Author

Laura Montserrat Pérez-López, Teresa Subirá-Álvarez, Amalia Martínez-Ruíz, Antoni Noguera-Julian, David Moreno-Romo, Ferran Torner-Rubies, and César Galo Fontecha

Subjects
Mycobacterium tuberculosis, Osteomyelitis, Arthritis, Pediatrics, Surgical Procedures, Operative, Orthopedic surgery, RD701-811
Abstract

Resumen: Introducción y objetivos: La tuberculosis (TBC) osteoarticular, causada por una bacteria del género Mycobacterium, representa alrededor de un 10% del total de TBC extrapulmonares en la edad pediátrica. Su baja prevalencia y su presentación clínica inespecífica conducen a un diagnóstico tardío y, con esto, a un mayor riesgo de secuelas. Pacientes y método: Presentamos una serie de siete casos pediátricos de TBC osteoarticular no vertebral diagnosticados entre el 2006 y el 2019, con una media de edad de 7,4 años y una mediana de cinco (rango de dos a 16 años).El tiempo medio de seguimiento fue de 18,5 meses (rango 10 a 32 meses).Los pacientes se clasificaron según los criterios radiográficos de Kerri y Martini. Resultados: El retraso diagnóstico fue constante, con una media de 4,7 meses (rango de uno a ocho meses).La localización fue: cabeza femoral (dos casos), húmero proximal, cúpula astragalina, osteoartritis de clavícula distal, epífisis proximal de cúbito, y articulaciones tibioastragalina junto con subastragalina. Los hallazgos clínicos fueron cojera (cuatro casos), dolor localizado (dos), impotencia funcional (dos), síndrome constitucional (astenia, anorexia y pérdida involuntaria de más del 5% del peso corporal total) (dos), signos inflamatorios locales (uno), y fiebre (uno). Un paciente fue asintomático, realizando el diagnóstico osteoarticular de manera casual en el estudio radiológico pulmonar.Se administró un tratamiento médico de inducción con tres o cuatro fármacos en todos los casos. En tres de ellos, fue necesario el desbridamiento quirúrgico, y, en dos se realizó un lavado vía artroscópica. Conclusiones: Los resultados finales fueron aceptables, con recuperación del balance articular en el 71% de los pacientes, pero con cambios radiográficos residuales en cuatro de los siete casos (57,1%). El mejor pronóstico parece correlacionarse con la menor edad, así como con el diagnóstico y el tratamiento médico-quirúrgico precoces. Abstract: Introduction and objectives: Osteoarticular tuberculosis, caused by a member of the Mycobacterium genus, represents approximately 10% of the total extrapulmonary tuberculosis in pediatric patients. Its low prevalence and nonspecific clinical presentation lead to a late diagnosis and elevated risk of sequelae. Patients and methods: This retrospective study included seven pediatric patients with non-vertebral osteoarticular tuberculosis diagnosed between 2006 and 2019. The patients were classified in accordance with the radiographic criteria of Kerri and Martini. Results: The mean patient age was 7,4 years (median, 5 years; range, 2–16 years). The mean follow-up time was 18,5 months (range, 10–32 months). The mean diagnostic delay was 4,7 months (range, 1-8 months). The locations were femoral head osteoarthritis (two patients) and proximal humerus osteomyelitis, talus dome osteoarthritis, distal clavicle osteoarthritis, proximal ulna epiphysis osteoarthritis, and tibiotalar arthritis along with subtalar gland (one patient each). The clinical findings were lameness (four patients), localized pain (two patients), functional impotence, constitutional syndrome (asthenia, anorexia, and involuntary loss of>5% of total body weight) (two patients), local inflammatory signs (one patient), and fever (one patient). One patient was asymptomatic and received a diagnosis during pulmonary radiological analysis. Medical treatment with four drugs was performed in all patients; five patients required surgical treatment for abscess drainage, three of them open drainage, and two with laparoscopic drainage. Conclusions: The final results were satisfactory, such that 71% of patients recovered joint balance but with radiological sequelae in 57,1% patients. Good prognosis, according to our results, depends on younger age and early diagnosis with early medical or surgical treatments.

Published
2021
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7. Canalización arterial ecoguiada o por palpación del pulso en la unidad de cuidados intensivos

Author

Ignacio Oulego-Erroz, Juan Mayordomo-Colunga, Rafael González-Cortés, María Sánchez-Porras, Ana Llorente-de la Fuente, Sira Fernández-de Miguel, Mónica Balaguer-Gargallo, Manuel Frías-Pérez, Antonio Rodríguez-Nuñez, María Sánchez- Porras, Paula Santos-Herraiz, Pilar García-Soler, Carmen Clavero-Rubio, Juanjo Menéndez-Suso, Alicia Mirás-Veiga, Emilia Fernández-Romero, María Pino-Velázquez, Luis Renter-Valdovinos, Esther Jiménez, Manuel Ortiz-Pallarés, Amalia Martínez-Antón, Virgina González-Ojeda, Soledad Torrús-Carmona, María- García Barba, Daniel Palanca-Arias, María Soledad Holanda-Peña, and Carolina González-Miño

Subjects
Ultrasound, Cannulation, Artery, Paediatric intensive care, Pediatrics, RJ1-570
Abstract

Resumen: Introducción: El uso de la ecografía ha demostrado mejorar los resultados de la canalización venosa central. Sin embargo, sus beneficios en la canalización arterial en niños no han sido claramente establecidos. El objetivo de este estudio fue evaluar el uso de la ecografía en la canalización arterial en la unidad de cuidados intensivos pediátricos (UCIP). Métodos: Estudio prospectivo multicéntrico en 18 UCIP en España durante un periodo de 6 meses. Se compararon los resultados de la canalización arterial ecoguiada (ECO) con la técnica tradicional basada en referencias anatómicas (REF) en cuanto a la tasa de éxito y las complicaciones inmediatas. Resultados: Se incluyeron 161 procedimientos en 128 pacientes (78 procedimientos en el grupo ECO y 83 en el grupo REF). La mediana (rango intercuartil) de edad y peso de los pacientes fueron 11 meses (2-52) y 10 kg (4-17), respectivamente; el 59,6% eran varones. La ecografía se utilizó preferentemente en las UCIP de mayor tamaño (número de camas 11 [8-16] vs 6 [4-10], p

Published
2021
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8. Ultrasound-guided arterial cannulation or by pulse palpation in the intensive care unit

Author

Ignacio Oulego-Erroz, Juan Mayordomo-Colunga, Rafael González-Cortés, María Sánchez-Porras, Ana Llorente-de la Fuente, Sira Fernández-de Miguel, Mónica Balaguer-Gargallo, Manuel Frías-Pérez, Antonio Rodríguez-Nuñez, María Sánchez- Porras, Paula Santos-Herraiz, Pilar García-Soler, Carmen Clavero-Rubio, Juanjo Menéndez-Suso, Alicia Mirás-Veiga, Emilia Fernández-Romero, María Pino-Velázquez, Luis Renter-Valdovinos, Esther Jiménez, Manuel Ortiz-Pallarés, Amalia Martínez-Antón, Virgina González-Ojeda, Soledad Torrús-Carmona, María-García Barba, Daniel Palanca-Arias, María Soledad Holanda-Peña, and Carolina González-Miño

Subjects
Ecografía, Canalización, Arteria, Cuidados intensivos pediátricos, Pediatrics, RJ1-570
Abstract

Introduction: Ultrasound (US) guidance increases the success rate and decreases complications during central venous catheterisation (CVC). The benefits of US guidance in arterial catheterisation are less clear. The aim of this study is to compare the outcomes of US-guided arterial catheterisation with the traditional landmark (LM) technique in critically ill children. Methods: A prospective multicentre study was carried out in 18 Paediatric Intensive Care units in Spain during a 6-months period. Ultrasound guided and landmark techniques were compared in terms of cannulation technical success and immediate mechanical complications. Results: A total of 161 procedures were performed on 128 patients (78 procedures in the US group and 83 in the LM groups).. The median (interquartile range) age and weight of the cohort was 11 months (2–52), and 10 kg (4–17) respectively. More than half (59.6%) were male. US was used mainly in high-volume-high-complexity hospitals (cardiac surgery program 76.9% vs. 25.6%, P

Published
2021
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9. Correction to: The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Author

Antoni Torres, Anna Motos, Jordi Riera, Laia Fernández-Barat, Adrián Ceccato, Raquel Pérez-Arnal, Dario García-Gasulla, Oscar Peñuelas, José Angel Lorente, Alejandro Rodriguez, David de Gonzalo-Calvo, Raquel Almansa, Albert Gabarrús, Rosario Menéndez, Jesús F. Bermejo-Martin, Ricard Ferrer, Rosario Amaya Villar, José M. Añón, Carme Barberà, José Barberán, Aaron Blandino Ortiz, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Cristóbal Galbán, Víctor D. Gumucio-Sanguino, Maria del Carmen de la Torre, Emili Díaz, Ángel Estella, Elena Gallego, José Luis García Garmendia, José Garnacho-Montero, José M. Gómez, Arturo Huerta, Ruth Noemí Jorge García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, Ignacio Martínez Varela, Juan López Messa, Guillermo M. Albaiceta, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Pilar Ricart, Inmaculada Salvador-Adell, Angel Sánchez-Miralles, Susana Sancho Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suares Sipmann, Luis Tamayo Lomas, José Trenado, Ferran Barbé, and CIBERESUCICOVID Project (COV20/00110, ISCIII)

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published
2021
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10. Audit of Anesthetic Equipment in Veterinary Clinics in Spain and Portugal

Author

Jose I. Redondo, Luis Domenech, Cristina Mateu, Alfon Bañeres, Amalia Martínez, and Diana Lopes

Subjects
anesthesia, veterinary, equipment malfunction, safety, anesthetic machine, vaporizer, Veterinary medicine, SF600-1100
Abstract

The objective of this retrospective study was to review the results of a 4-year audit performed on anesthetic machines and vaporizers used in veterinary clinics in Spain and Portugal. Data was collected between July 2016 and April 2020. Inspections were carried out by a team of seven veterinarians, using a human-modified system of checks that was adapted to a veterinary practice. The evaluation of each item was noted as “correct” or “incorrect”. The vaporizers' performance was evaluated using a self-calibrating gas analyzer. The vaporizer was classified as “correct” or “incorrect” when the vaporization error was less than or equal to, or more than 20%, respectively. The anesthetic machine was classified as “conforming” if all its components were noted as “correct” and no leaks were detected, or as “non-conforming” if any of the components was noted as “incorrect” or if a leak was detected. If the inspector was able to repair on-site the item malfunctions detected and the machine was fit for use, they issued a final report as “conforming.” On the contrary, if such malfunctions persisted, the final report was “non-conforming,” and a recommendation to remove the machine from service until its final repair was provided. To perform statistical analysis, each inspected item was used as predictor, classification and regression trees were built, and a random forest analysis was performed. A total of 2,001 anesthetic machines and 2,309 vaporizers were studied. After inspection, 42.7 and 26.4% of the machines were non-conforming and conforming, respectively, whereas 30.9% could be repaired in situ. A total of 27.1% of the isoflurane vaporizers and 35.9% of the sevoflurane vaporizers were incorrect. Machine learning techniques showed that the most important variables in the classification of the anesthetic machines as conforming or non-conforming were mostly the scavenger system and the canister, followed some way behind by the APL valve, source of oxygen, reservoir bag, vaporizer, and connections.

Published
2020
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11. Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

Author

Ane Abad-motos, Jesús Troya, Eva Jiménez, Mario Fontán-Vela, Jorge Valencia, Ines Fernandez-Jimenez, Elena Alba Álvaro-Alonso, Elsa Izquierdo-García, Andrea Lazaro Cebas, Elisa Gallego Ruiz-Elvira, Ana Josefa Tebar-Martinez, Belén Garcia-Marina, Gabriela Peña-Lillo, Laura Macaya, Pablo Ryan, Mario Pérez-Butragueño, Blanca Herrero Mendoza, Natividad Plazas Andreu, Liliana Vázquez Bol, Sandra María Gadin López, Álvaro Martínez Alcalá, Sonia Pérez Gonzalez, Amalia Martínez de la Gándara, Alejandro Zuazua Gonzalez, Javier Montoya Adarraga, Miguel Ángel Lara Álvarez, Enrique Calvo Aranda, Rosa M Lorente Ramos, María Alcantud, Roberto Alcázar Arroyo, Verónica Suberviola Sánchez-Caballero, Ariela Candelario Cáceres, Juan Churruca Sarasqueta, Juan Torres Macho, Ismael Escobar Rodríguez, Raquel Ruíz Páez, Alberto Esquivel López, Pablo de la Cueva Dobao, Natalia Blanca López, José García Hinojosa, Cristina Sevillano Collantes, Alfonso Camacho Aroca, Tamar Talaván Zañón, María Ángeles Sánchez Úriz, Carlos Bibiano Guillén, Miguel Ángel López Arenas, Margarita Gimeno Arández, and Francisco Javier Quintero Gutiérrez del Álamo

Subjects
Medicine
Abstract

Objectives To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.Design and setting Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.Participants All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.Results A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0–81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51–71); 74.1% men; median length of stay 9 days (IQR 5–19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6–14).Conclusions This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.

Published
2020
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12. Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2

Author

Valentina Rivas Acuña, Yadira Mateo Crisóstomo, Herminia García Barjau, Amalia Martínez Serrano, Margarita Magaña Castillo, and Rodolfo Gerónimo Carrillo

Subjects
Diabetes Mellitus, Polineuropatías, Pie Diabético, Autocuidado., Nursing, RT1-120
Abstract

Introducción: Actualmente la diabetes mellitus tipo 2 es considerada una epidemia en el mundo, es uno de los problemas de mayor trascendencia, por su alta prevalencia como por su enorme repercusión social y económica, por tal motivo el propósito del estudio fue evaluar de manera integral la sensibilidad en los pies de las personas con diabetes mellitus tipo 2, de Villahermosa, Tabasco, México. Materiales y Métodos: El diseño fue descriptivo correlacional, la muestra fue de 198 personas. Se utilizó el Test del Michigan Neuropathy Screening con monofilamento de Semme Weinstein, Diapasón, temperatura frío/calor y reflejo Aquileo. Resultados y Discusión: El sexo femenino predominó con un 70.2% y el 29.8% hombres, el promedio de edad fue 56.44 años y 12.34 años promedio con la enfermedad. El 46% registró síntomas neuropáticos moderados, 26.3% graves; el 65.7% riesgo de neuropatía positiva (40.9% mujeres y 24.8% hombres), 41.1% con pérdida de sensibilidad moderada y 29.3% sensibilidad normal; el 74.7% tiene un control glucémico deficiente. Los factores de riesgo detectados con mayor prevalencia fueron helomas, hiperqueratosis y deformidades. Conclusiones: Existe una correlación significativa entre la pérdida de la sensibilidad con los años con la enfermedad, con la hiperglucemia y síntomas de neuropatía, la pérdida de sensibilidad en mujeres es de moderada a grave y en los hombres la pérdida de la sensibilidad es moderada. Cómo citar este artículo: Rivas V, Mateo Y, García H, Martínez A, Magaña M, Carrillo R. Evaluación integral de la sensibilidad en los pies de las personas con diabetes mellitus tipo 2. Rev Cuid. 2017; 8(1):1423-32. http://dx.doi.org/10.15649/cuidarte.v8i1.348

Published
2017
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13. Percepción del apoyo familiar y difiultades relacionadas con la diabetes en el adulto mayor

Author

Zoyla Merodio Pérez, Valentina Rivas Acuña, and Amalia Martínez Serrano

Subjects
percepción, apoyo familiar, diabetes mellitus tipo 2 y adulto mayor, Medicine
Abstract

Objetivo. Describir la percepción del apoyo familiar y las dificultades relacionadas con la diabetes en el adulto mayor de la unidad de medicina familiar del ISSET. Material y métodos: El diseño fue descriptivo transversal, muestreo por conveniencia y muestra de 113 adultos mayores con diabetes. Se utilizó la Escala de Redes de Apoyo Social para los Adultos Mayores (ERASAM) y cuestionarios para identificar las áreas †problema de la diabetes (PAID-1 Y PAID-2). Los datos se procesaron con el SPSS versión 15.0. Resultados: 69.9% mujeres y †30.1% hombres, †promedio de edad †de 66 años (DE=7.10), estado civil: 63.7% casados; 85% tiene vivienda propia. Las redes de apoyo los adultos mayores; 68.1% cuenta con esposo, todos tienen hijos, el 93.8% con familiares próximos (parientes, hermanos, sobrinos y primo); en la red informal extra familiar 92.9 % cuenta con amigos y 9% por un grupo comunitario. En relación a los problemas con la diabetes: 49.6% de los AM se preocupan por los problemas del futuro; 42.5% no realiza actividades físicas de manera suficiente; 29.2% refiere tener vigilancia estricta de familiares, 24.8% realiza consultas poco frecuentes y breves. 64.7% de los hombres y el 60.8% de mujeres tienen glucosa descontrolada. Estos hallazgos †difieren del estudio de Sedó, (2010) quien refiere que las mujeres, a diferencia de los varones, controlan la glucosa casi inmediatamente †después de que fueron diagnosticadas. Conclusiones: En el presente estudio el promedio de edad de los adultos mayores fue de 66 años, †existe mayor predominio en el sexo femenino, esto coincide con el incremento de la prevalencia de las mujeres con diabetes en México donde hay un †incremento a partir de los 40 años de edad; se ha confirmado que el mejor apoyo lo reciben los hombres, comparado con el bajo soporte familiar concerniente a las mujeres esto influye en el aspecto cultural de nuestro pueblo

Published
2015
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14. Cálculo de la incertidumbre estándar mediante la técnica de Monte Carlo para la medición de la topografía y del campo de desplazamiento mediante ESPI

Author

Jorge Ramón Parra-Michel and Amalia Martínez García

Subjects
Science, Science (General), Q1-390, Social Sciences, Social sciences (General), H1-99
Abstract

La ventaja del uso de las técnicas interferométricas basados en el patrón de moteado ESPI (electronic speckle pattern interferometry) es única ya que se pueden hacer mediciones muy precisas de los campos de desplazamientos que ocurren en la superficie de algún elemento mecánico cuando se deforma. Sin embargo, cuando se utiliza la iluminación divergente, se observa que la medición de los campos de desplazamientos está en función de la topografía del objeto. Por tal motivo, antes de evaluar las deformaciones mecánicas por la técnica ESPI con iluminación divergente es necesario conocer la topografía del objeto. La estimación de la incertidumbre estándar de las mediciones de los campos de desplazamiento debe de contemplar la incertidumbre de las mediciones de la topografía que se propaga debido a la ley generalizada de la propagación de la incertidumbre. En este trabajo se muestra el uso de la técnica de Monte Carlo para el cálculo de la incertidumbre estándar para la las mediciones de los campos de desplazamiento y la topografía de superficie de objetos mediante la técnica de interferometría electrónica del patrón de moteado con iluminación dual y divergente.

Published
2012

15. Total and free fatty acids content during the ripening of artisan and industrially manufactured 'Chorizo de cebolla'

Author

Inmaculada Franco, Amalia Martínez, Bernardo Prieto, and Javier Carballo

Subjects
chorizo de cebolla, free fatty acids, lipolysis, raw-cured sausages, ripening, total fatty acids, Nutrition. Foods and food supply, TX341-641
Abstract

“Chorizo de cebolla” is a traditional sausage made in the north west of Spain. In four batches manufactured by artisanal methods and 4 manufactured by industrial ones the contents of total and free fatty acids were assessed throughout ripening, taking from every batch samples of the mass before stuffing (0 days) and of the sausage after 2, 7, 14, 21, 28 and 42 days of ripening. The profile of total fatty acids of the two types of sausage basically coincide with that found by other authors in pork fat. However, both types of sausage (artisanal and industrial) differ significantly (p< 0.05) in the percentage of totally saturated and unsaturated fatty acids. The artisanal manufactured sausages showed percentages of saturated fatty acids significantly superior to those found in industrial sausages. The content of total free fatty acids underwent throughout ripening a significant increase (p< 0.05) from average values of 459 ± 243 mg/100 g of fat in the mass up to 3687 ± 1670 mg/100 g of fat in the sausage of 42 days in the artisanal sausage, and from 560 ± 317 mg/100 g of fat up to 5157 ± 3673 mg/100 g in the industrial ones. Owing to the great variation between the different batches, significant differences were not found in the contents of total free fatty acids between both types of sausages, though at the end of ripening the average content was 1.4 times superior in the industrial sausages. In both types of sausages, the main free fatty acids at the end of ripening were, in this order, oleic, linoleic and palmitic, whose addition represented 83 % of total free fatty acids.

Published
2002
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16. Cálculo de la incertidumbre estándar mediante la técnica de Monte Carlo para la medición de la topografía y del campo de desplazamiento mediante ESPI

Author

Jorge Ramón Parra-Michel and Amalia Martínez García

Subjects
Interferometría del patrón de moteado, ESPI, incertidumbre estándar, Monte Carlo, Science, Science (General), Q1-390, Social Sciences, Social sciences (General), H1-99
Abstract

La ventaja del uso de las técnicas interferométricas basados en el patrón de moteado ESPI (electronic speckle pattern interferometry) es única ya que se pueden hacer mediciones muy precisas de los campos de desplazamientos que ocurren en la superficie de algún elemento mecánico cuando se deforma. Sin embargo, cuando se utiliza la iluminación divergente, se observa que la medición de los campos de desplazamientos está en función de la topografía del objeto. Por tal motivo, antes de evaluar las deformaciones mecánicas por la técnica ESPI con iluminación divergente es necesario conocer la topografía del objeto. La estimación de la incertidumbre estándar de las mediciones de los campos de desplazamiento debe de contemplar la incertidumbre de las mediciones de la topografía que se propaga debido a la ley generalizada de la propagación de la incertidumbre. En este trabajo se muestra el uso de la técnica de Monte Carlo para el cálculo de la incertidumbre estándar para la las mediciones de los campos de desplazamiento y la topografía de superficie de objetos mediante la técnica de interferometría electrónica del patrón de moteado con iluminación dual y divergente.

Published
2014
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18. Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units

Author

Torres, Antoni, Motos, Anna, Ceccato, Adrián, Bermejo-Martin, Jesús, de Gonzalo-Calvo, David, Pérez, Raquel, Barroso, Marta, Pascual, Ion Zubizarreta, Gonzalez, Jessica, Fernández-Barat, Laia, Ferrer, Ricard, Riera, Jordi, García-Gasulla, Dario, Peñuelas, Oscar, Lorente, José Ángel, Almansa, Raquel, Menéndez, Rosario, Kiarostami, Kasra, Canseco, Joan, Villar, Rosario Amaya, Añón, José M., Mariño, Ana Balan, Barberà, Carme, Barberán, José, Ortiz, Aaron Blandino, Boado, Maria Victoria, Bustamante-Munguira, Elena, Caballero, Jesús, Cantón-Bulnes, María Luisa, Pérez, Cristina Carbajales, Carbonell, Nieves, Catalán-González, Mercedes, de Frutos, Raúl, Franco, Nieves, Galbán, Cristóbal, Gumucio-Sanguino, Víctor D., Torre, María del Carmen de la, Díaz, Emili, Estella, Ángel, Gallego, Elena, Garmendia, José Luis García, Gómez, José M., Huerta, Arturo, García, Ruth Noemí Jorge, Loza-Vázquez, Ana, Marin-Corral, Judith, Delgado, María Cruz Martin, Gándara, Amalia Martínez de la, Varela, Ignacio Martínez, Messa, Juan López, Albaiceta, Guillermo M., Nieto, Maite, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez-García, Felipe, Pozo-Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Víctor, Sánchez-Miralles, Ángel, Chinesta, Susana Sancho, Serra-Fortuny, Mireia, Socias, Lorenzo, Solé-Violan, Jordi, Suárez-Sipmann, Fernando, Lomas, Luis Tamayo, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, and Barbé, Ferran

Published
2022
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19. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19: A 3-Month Prospective Cohort

Author

Villar, Rosario Amaya, Añón, José M., Barberà, Carme, Barberán, José, Ortiz, Aaron Blandino, Bustamante-Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán-González, Mercedes, Galbán, Cristóbal, Gumucio, Victor Daniel, de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho-Montero, José, Gómez, José M., Huerta, Arturo, Jorge García, Ruth Noemí, Loza-Vázquez, Ana, Marin-Corral, Judith, de la Gándara, Amalia Martínez, Varela, Ignacio Martínez, Messa, Juan Lopez, Albaiceta, Guillermo M., Novo, Mariana Andrea, Peñasco, Yhivian, Pozo-Laderas, Juan Carlos, Martí, Pilar Ricart, Roche-Campo, Ferran, Sánchez-Miralles, Angel, Chinesta, Susana Sancho, Socias, Lorenzo, Solé-Violan, Jordi, Sipmann, Fernando Suares, Lomas, Luis Tamayo, Trenado, José, González, Jessica, Benítez, Iván D., Carmona, Paola, Santisteve, Sally, Monge, Aida, Moncusí-Moix, Anna, Gort-Paniello, Clara, Pinilla, Lucía, Carratalá, Amara, Zuil, María, Ferrer, Ricard, Ceccato, Adrián, Fernández, Laia, Motos, Ana, Riera, Jordi, Menéndez, Rosario, Garcia-Gasulla, Dario, Peñuelas, Oscar, Bermejo-Martin, Jesús F., Labarca, Gonzalo, Caballero, Jesus, Torres, Gerard, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran

Published
2021
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20. Crecimiento compensatorio en el borrego pelibuey

Author

Raúl F. Bores Quintero, Amalia Martínez Avalos, and Arturo F. Castellanos Ruelas

Subjects
borrego, pelibuey, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
Abstract

Este trabajo tuvo el objeto de estudiar el crecimiento compensatorio del borrego Pelibuey alimentado con una dieta de producción después de someterse a dietas con diversos aportes restringidos de energía

Published
1988

21. Efecto de la adición de niveles crecientes de carbohidratos solubles en la dieta de ovinos sobre el aprovechamiento ruminal de carbohidratos estructurales

Author

Raúl Bores Quintero, Amalia Martínez Avalos, and Arturo Castellanos Ruelas

Subjects
carbohidratos, ruminal, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
Abstract

La utilización de melaza como suplemento energético es una práctica común en las explotaciones ganaderas, primordialmente por su bajo costo.

Published
1986

22. Clinical Outcomes of Critical COVID-19 in HIV-Infected Adults: A Propensity Score Matched Analysis

Author

Cilloniz, Catia, primary, Motos, Anna, additional, Canseco, Joan, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Abril, Elena, additional, García, José Manuel Gómez, additional, Ortiz, Aaron Blandino, additional, Mateo, Nadia García, additional, Sánchez-Miralles, Ángel, additional, Franco, Nieves, additional, Riera, Jordi, additional, Ferrer, Ricard, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Gándara, Amalia Martínez de la, additional, Sancho, Susana, additional, Masclans, Joan-Ramon, additional, Urrelo-Cerrón, Luis, additional, Carbonell, Nieves, additional, Socías, Lorenzo, additional, Barberà, Carme, additional, Lorente, José A., additional, Rodríguez, Óscar Peñuelas, additional, Menéndez, Rosario, additional, de Gonzalo-Calvo, David, additional, Ceccato, Adrian, additional, Fernandez-Barat, Laia, additional, Garcia-Gasulla, Dario, additional, Gabarrus, Albert, additional, Garcia-Vidal, Carolina, additional, Moreno, Asunción, additional, Barbé, Ferran, additional, Miro, José M., additional, and Torres, Antoni, additional

Published
2023
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25. Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Author

Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, Salvador Resino, Luis Tamayo, Pablo Ryan Murua, Elena Bustamante-Munguira, Elena Gallego Curto, Alejandro Úbeda-Iglesias, María del Carmen de la Torre, Ángel Estella, Sandra Campos-Fernández, Ignacio Martínez Varela, Felipe Pérez-García, Lorenzo Socias, Juan López Messa, Pablo Vidal-Cortés, Víctor Sagredo Meneses, Milagros González-Rivera, Nieves Carbonell, David de Gonzalo-Calvo, María Cruz Martín Delgado, Luis Jorge Valdivia, Caridad Martín-López, Ruth Noemí Jorge García, Emilio Maseda, Ana Loza-Vázquez, David J Kelvin, Ferrán Barbé, Antoni Torres, Alicia Ortega, Amanda de la Fuente, Raquel Almansa, Tamara Postigo, Noelia Jorge, Ana P Tedim, Laura González-González, Lara Sánchez Recio, Wysali Trapiello, José Ángel Berezo, Rubén Herrán-Monge, Jesús Blanco, Pedro Enríquez, Isidoro Martínez, María Martín-Vicente, María José Muñoz-Gómez, Vicente Más, Mónica Vázquez, Olga Cano, Amalia Martínez de la Gándara, Covadonga Rodríguez, Gloria Andrade, Gloria Renedo, Juan Bustamante-Munguira, Ramón Cicuendez Ávila, María Salgado-Villén, Enrique Berruguilla-Pérez, Estel Güell, Fernando Javier Casadiego Monachello, María Recuerda Núñez, Juan Manuel Sánchez Calvo, Yhivian Peñasco-Martín, María Teresa García Unzueta, Adrián Ceccato, Laia Fernández-Barat, María Teresa Bouza Vieiro, Ana Moreno-Romero, Leire Pérez Bastida, Lorena del Río-Carbajo, Noelia Albalá Martínez, José Manuel Gómez, María Luisa Blasco, Jesús Caballero, Carme Barberà, Jessica González, María Teresa Nieto, Jorge Nieto-del Olmo, Estefanía Prol-Silva, Joan Canseco-Ribas, Jose María Eiros, Instituto de Salud Carlos III, Canadian Institutes of Health Research, Li Ka Shing Foundation, European Society of Clinical Microbiology and Infectious Diseases, Centro de Investigación Biomédica en Red - CIBERES (Enfermedades Respiratorias), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), and Unión Europea. Fondo Social Europeo (ESF/FSE)

Subjects
Microbiology (medical), Infectious Diseases, Spain, Virology, COVID-19, Microbiology
Abstract

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero (2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16-0·55; p

Published
2023

26. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Cillóniz, Catia, primary, Motos, Anna, additional, Castañeda, Tatiana, additional, Gabarrús, Albert, additional, Barbé, Ferran, additional, Torres, Antoni, additional, Gumucio-Sanguino, Víctor D., additional, Mañez, Rafael, additional, Solé-Violan, Jordi, additional, de Castro, Felipe Rodríguez, additional, Suarez-Sipmann, Fernando, additional, García, Ruth Noemí Jorge, additional, Aznar, María Mora, additional, Torres, Mateu, additional, Martinez, María, additional, Alegre, Cynthia, additional, Riera, Jordi, additional, Contreras, Sofía, additional, Pericas, Juan Manuel, additional, Ferrer, Ricard, additional, Caballero, Jesús, additional, Trujillano, Javier, additional, Vallverdú, Montse, additional, León, Miguel, additional, Badía, Mariona, additional, Balsera, Begoña, additional, Servià, Lluís, additional, Vilanova, Judit, additional, Rodríguez, Silvia, additional, Montserrat, Neus, additional, Iglesias, Silvia, additional, Prados, Javier, additional, Carvalho, Sula, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Jiménez, Gabriel, additional, Codina, Jordi, additional, Val, Estela, additional, Pagliarani, Pablo, additional, Rubio, Jorge, additional, Morales, Dulce, additional, Pujol, Andrés, additional, Furro, Àngels, additional, García, Beatriz, additional, Torres, Gerard, additional, Vengoechea, Javier, additional, Gonzalo-Calvo, David de, additional, González, Jessica, additional, Gomez, Silvia, additional, Gómez, José M., additional, Franco, Nieves, additional, Barberán, José, additional, Albaiceta, Guillermo M, additional, Espina, Lorena Forcelledo, additional, Prieto, Emilio García, additional, Vicente, Paula Martín, additional, del Busto Martínez, Cecilia, additional, Vidal-Cortés, Pablo, additional, Garmendia, José Luis García, additional, Cabello, María Aguilar, additional, Fernández, Carmen Eulalia Martínez, additional, Carbonell, Nieves, additional, Cortés, María Luisa Blasco, additional, Lázaro, Ainhoa Serrano, additional, Díaz, Mar Juan, additional, Ortiz, Aaron Blandino, additional, Menendez, Rosario, additional, Valdivia, Luis Jorge, additional, Boado, María Victoria, additional, Chinesta, Susana Sancho, additional, del Carmen de la Torre, Maria, additional, Varela, Ignacio Martínez, additional, Vieiro, María Teresa Bouza, additional, Arijón, Inés Esmorís, additional, Hermoso, David Campi, additional, Salinas, Rafaela Nogueras, additional, Monjo, Teresa Farre, additional, Bou, Ramon Nogue, additional, Naya, Gregorio Marco, additional, Barberà, Carme, additional, Coll, Núria Ramon, additional, Catalán-González, Mercedes, additional, Montejo-González, Juan Carlos, additional, Sanchez-Giron, Gloria Renedo, additional, Bustamante-Munguira, Juan, additional, Bustamante-Munguira, Elena, additional, Avila, Ramon Cicuendez, additional, Herrera, Nuria Mamolar, additional, Almansa, Raquel, additional, Ortega, Alicia, additional, Bermejo-Martin, Jesús, additional, Sagredo, Víctor, additional, Añon, Jose, additional, Agrifoglio, Alexander, additional, Cachafeiro, Lucia, additional, Maseda, Emilio, additional, Socias, Lorenzo, additional, Novo, Mariana Andrea, additional, Figueras, Albert, additional, Janer, Maria Teresa, additional, Soliva, Laura, additional, Ocón, Marta, additional, Clar, Luisa, additional, Ayestarán, J Ignacio, additional, Peñasco, Yhivian, additional, Fernández, Sandra Campos, additional, Serra-Fortuny, Mireia, additional, Forcadell-Ferreres, Eva, additional, Salvador-Adell, Immaculada, additional, Bofill, Neus, additional, Adell-Serrano, Berta, additional, Díaz, Josep Pedregosa, additional, Casacuberta-Barberà, Núria, additional, Urrelo-Cerrón, Luis, additional, Piñol-Tena, Àngels, additional, Roche-Campo, Ferran, additional, de la Gándara, Amalia Martínez, additional, Murúa, Pablo Ryan, additional, Ruíz, Covadonga Rodríguez, additional, García, Laura Carrión, additional, Álvarez, Juan I Lazo, additional, Lorente, José Ángel, additional, Loza-Vázquez, Ana, additional, Guerrero, Desire Macias, additional, Huerta, Arturo, additional, Tognetti, Daniel, additional, Redruello, Carlos García, additional, Rodríguez, David Mosquera, additional, Fernández, Eva María Menor, additional, Adrio, Sabela Vara, additional, Casal, Vanesa Gómez, additional, Pensado, Marta Segura, additional, Vilas, María Digna Rivas, additional, Sagastume, Amaia García, additional, de Pablo Sánchez, Raul, additional, Laguna, David Pestaña, additional, Bardi, Tommaso, additional, Villar, Rosario Amaya, additional, Gonzalez, Carmen Gómez, additional, Castillo, Maria Luisa Gascón, additional, Garnacho-Montero, José, additional, Cantón-Bulnes, María Luisa, additional, Marin-Corral, Judith, additional, Pérez, Cristina Carbajales, additional, Masclans, Joan Ramon, additional, Degracia, Ana Salazar, additional, Bigas, Judit, additional, Muñoz-Bermúdez, Rosana, additional, Vilà-Vilardel, Clara, additional, Parrilla, Francisco, additional, Dot, Irene, additional, Zapatero, Ana, additional, Díaz, Yolanda, additional, Gracia, María Pilar, additional, Pérez, Purificación, additional, Castellví, Andrea, additional, Climent, Cristina, additional, Serra, Lidia, additional, Barbena, Laura, additional, Cano, Iosune, additional, Ricart, Pilar, additional, Herraiz, Alba, additional, Marcos, Pilar, additional, Rodríguez, Laura, additional, Sariñena, Maria Teresa, additional, Sánchez, Ana, additional, Úbeda, Alejandro, additional, Delgado, María Cruz Martin, additional, Gallego, Elena, additional, Jimenez, Juan Fernando Masa, additional, Gomà, Gemma, additional, Díaz, Emi, additional, Ibarz, Mercedes, additional, De Mendoza, Diego, additional, Barbeta, Enric, additional, Alcaraz-Serrano, Victoria, additional, Badia, Joan Ramon, additional, Castella, Manuel, additional, Bueno, Leticia, additional, Ceccato, Adrian, additional, Palomeque, Andrea, additional, Barat, Laia Fernandez, additional, Cillóniz, Catia, additional, Conde, Pamela, additional, Fernández, Javier, additional, Gabarrus, Albert, additional, Kiarostami, Karsa, additional, López-Gavín, Alexandre, additional, Mantellini, Cecilia L, additional, Speziale, Carla, additional, Vázquez, Nil, additional, Yang, Hua, additional, Yang, Minlan, additional, Ferrando, Carlos, additional, Castro, Pedro, additional, Arrieta, Marta, additional, Nicolas, Jose Maria, additional, Andrea, Rut, additional, Barroso, Marta, additional, Pérez, Raquel, additional, Álvarez, Sergio, additional, Garcia-Gasulla, Dario, additional, Tormos, Adrián, additional, Lomas, Luis Tamayo, additional, Aldecoa, Cesar, additional, Herrán-Monge, Rubén, additional, García, José Ángel Berezo, additional, Giraudo, Pedro Enríquez, additional, Fernández, Pablo Cardinal, additional, López, Alberto Rubio, additional, Pravia, Orville Báez, additional, Messa, Juan López, additional, Bastida, Leire Pérez, additional, Ruiz, Antonjo Alvarez, additional, Trenado, José, additional, Pous, Anna Parera, additional, Galbán, Cristóbal, additional, Lago, Ana López, additional, Paz, Eva Saborido, additional, Segade, Patricia Barral, additional, Mariño, Ana Balan, additional, Mendez, Manuel Valledor, additional, de Frutos, Raúl, additional, Aguilera, Luciano, additional, Pérez-García, Felipe, additional, López-Ramos, Esther, additional, Ruiz-García, Ángela Leonor, additional, Beteré, Belén, additional, Blancas, Rafael, additional, Dólera, Cristina, additional, Planelles, Gloria Perez, additional, Peis, Enrique Marmol, additional, Juan, Maria Dolores Martinez, additional, Miralles, Miriam Ruiz, additional, Rubio, Eva Perez, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Sánchez-Miralles, Ángel, additional, Warrington, Tatiana Villada, additional, Pozo-Laderas, Juan Carlos, additional, Estrella, Angel, additional, Cano, Sara Guadalupe Moreno, additional, Gordo, Federico, additional, Palacios, Basilisa Martinez, additional, Nieto, Maite, additional, Nieto, Maria Teresa, additional, Ossa, Sergio, additional, Ortega, Ana, additional, Sanchez, Miguel, additional, and Santacoloma, Bitor, additional

Published
2023
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27. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Catia Cillóniz, Anna Motos, Tatiana Castañeda, Albert Gabarrús, Ferran Barbé, Antoni Torres, Víctor D. Gumucio-Sanguino, Rafael Mañez, Jordi Solé-Violan, Felipe Rodríguez de Castro, Fernando Suarez-Sipmann, Ruth Noemí Jorge García, María Mora Aznar, Mateu Torres, María Martinez, Cynthia Alegre, Jordi Riera, Sofía Contreras, Juan Manuel Pericas, Ricard Ferrer, Jesús Caballero, Javier Trujillano, Montse Vallverdú, Miguel León, Mariona Badía, Begoña Balsera, Lluís Servià, Judit Vilanova, Silvia Rodríguez, Neus Montserrat, Silvia Iglesias, Javier Prados, Sula Carvalho, Mar Miralbés, Josman Monclou, Gabriel Jiménez, Jordi Codina, Estela Val, Pablo Pagliarani, Jorge Rubio, Dulce Morales, Andrés Pujol, Àngels Furro, Beatriz García, Gerard Torres, Javier Vengoechea, David de Gonzalo-Calvo, Jessica González, Silvia Gomez, José M. Gómez, Nieves Franco, José Barberán, Guillermo M Albaiceta, Lorena Forcelledo Espina, Emilio García Prieto, Paula Martín Vicente, Cecilia del Busto Martínez, Pablo Vidal-Cortés, José Luis García Garmendia, María Aguilar Cabello, Carmen Eulalia Martínez Fernández, Nieves Carbonell, María Luisa Blasco Cortés, Ainhoa Serrano Lázaro, Mar Juan Díaz, Aaron Blandino Ortiz, Rosario Menendez, Luis Jorge Valdivia, María Victoria Boado, Susana Sancho Chinesta, Maria del Carmen de la Torre, Ignacio Martínez Varela, María Teresa Bouza Vieiro, Inés Esmorís Arijón, David Campi Hermoso, Rafaela Nogueras Salinas, Teresa Farre Monjo, Ramon Nogue Bou, Gregorio Marco Naya, Carme Barberà, Núria Ramon Coll, Mercedes Catalán-González, Juan Carlos Montejo-González, Gloria Renedo Sanchez-Giron, Juan Bustamante-Munguira, Elena Bustamante-Munguira, Ramon Cicuendez Avila, Nuria Mamolar Herrera, Raquel Almansa, Alicia Ortega, Jesús Bermejo-Martin, Víctor Sagredo, Jose Añon, Alexander Agrifoglio, Lucia Cachafeiro, Emilio Maseda, Lorenzo Socias, Mariana Andrea Novo, Albert Figueras, Maria Teresa Janer, Laura Soliva, Marta Ocón, Luisa Clar, J Ignacio Ayestarán, Yhivian Peñasco, Sandra Campos Fernández, Mireia Serra-Fortuny, Eva Forcadell-Ferreres, Immaculada Salvador-Adell, Neus Bofill, Berta Adell-Serrano, Josep Pedregosa Díaz, Núria Casacuberta-Barberà, Luis Urrelo-Cerrón, Àngels Piñol-Tena, Ferran Roche-Campo, Amalia Martínez de la Gándara, Pablo Ryan Murúa, Covadonga Rodríguez Ruíz, Laura Carrión García, Juan I Lazo Álvarez, José Ángel Lorente, Ana Loza-Vázquez, Desire Macias Guerrero, Arturo Huerta, Daniel Tognetti, Carlos García Redruello, David Mosquera Rodríguez, Eva María Menor Fernández, Sabela Vara Adrio, Vanesa Gómez Casal, Marta Segura Pensado, María Digna Rivas Vilas, Amaia García Sagastume, Raul de Pablo Sánchez, David Pestaña Laguna, Tommaso Bardi, Rosario Amaya Villar, Carmen Gómez Gonzalez, Maria Luisa Gascón Castillo, José Garnacho-Montero, María Luisa Cantón-Bulnes, Judith Marin-Corral, Cristina Carbajales Pérez, Joan Ramon Masclans, Ana Salazar Degracia, Judit Bigas, Rosana Muñoz-Bermúdez, Clara Vilà-Vilardel, Francisco Parrilla, Irene Dot, Ana Zapatero, Yolanda Díaz, María Pilar Gracia, Purificación Pérez, Andrea Castellví, Cristina Climent, Lidia Serra, Laura Barbena, Iosune Cano, Pilar Ricart, Alba Herraiz, Pilar Marcos, Laura Rodríguez, Maria Teresa Sariñena, Ana Sánchez, Alejandro Úbeda, María Cruz Martin Delgado, Elena Gallego, Juan Fernando Masa Jimenez, Gemma Gomà, Emi Díaz, Mercedes Ibarz, Diego De Mendoza, Enric Barbeta, Victoria Alcaraz-Serrano, Joan Ramon Badia, Manuel Castella, Leticia Bueno, Adrian Ceccato, Andrea Palomeque, Laia Fernandez Barat, Pamela Conde, Javier Fernández, Albert Gabarrus, Karsa Kiarostami, Alexandre López-Gavín, Cecilia L Mantellini, Carla Speziale, Nil Vázquez, Hua Yang, Minlan Yang, Carlos Ferrando, Pedro Castro, Marta Arrieta, Jose Maria Nicolas, Rut Andrea, Marta Barroso, Raquel Pérez, Sergio Álvarez, Dario Garcia-Gasulla, Adrián Tormos, Luis Tamayo Lomas, Cesar Aldecoa, Rubén Herrán-Monge, José Ángel Berezo García, Pedro Enríquez Giraudo, Pablo Cardinal Fernández, Alberto Rubio López, Orville Báez Pravia, Juan López Messa, Leire Pérez Bastida, Antonjo Alvarez Ruiz, José Trenado, Anna Parera Pous, Cristóbal Galbán, Ana López Lago, Eva Saborido Paz, Patricia Barral Segade, Ana Balan Mariño, Manuel Valledor Mendez, Raúl de Frutos, Luciano Aguilera, Felipe Pérez-García, Esther López-Ramos, Ángela Leonor Ruiz-García, Belén Beteré, Rafael Blancas, Cristina Dólera, Gloria Perez Planelles, Enrique Marmol Peis, Maria Dolores Martinez Juan, Miriam Ruiz Miralles, Eva Perez Rubio, Maria Van der Hofstadt Martin-Montalvo, Ángel Sánchez-Miralles, Tatiana Villada Warrington, Juan Carlos Pozo-Laderas, Angel Estrella, Sara Guadalupe Moreno Cano, Federico Gordo, Basilisa Martinez Palacios, Maite Nieto, Maria Teresa Nieto, Sergio Ossa, Ana Ortega, Miguel Sanchez, and Bitor Santacoloma

Subjects
Microbiology (medical), Infectious Diseases
Published
2022

29. Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis

Author

Riera, Jordi, primary, Barbeta, Enric, additional, Tormos, Adrián, additional, Mellado-Artigas, Ricard, additional, Ceccato, Adrián, additional, Motos, Anna, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, García-Gasulla, Darío, additional, Peñuelas, Oscar, additional, Lorente, José Ángel, additional, Menéndez, Rosario, additional, Roca, Oriol, additional, Palomeque, Andrea, additional, Ferrando, Carlos, additional, Solé-Violán, Jordi, additional, Novo, Mariana, additional, Boado, María Victoria, additional, Tamayo, Luis, additional, Estella, Ángel, additional, Galban, Cristóbal, additional, Trenado, Josep, additional, Huerta, Arturo, additional, Loza, Ana, additional, Aguilera, Luciano, additional, Garmendia, José Luís García, additional, Barberà, Carme, additional, Gumucio, Víctor, additional, Socias, Lorenzo, additional, Franco, Nieves, additional, Valdivia, Luis Jorge, additional, Vidal, Pablo, additional, Sagredo, Víctor, additional, Ruiz-García, Ángela Leonor, additional, Varela, Ignacio Martínez, additional, López, Juan, additional, Pozo, Juan Carlos, additional, Nieto, Maite, additional, Gómez, José M, additional, Blandino, Aaron, additional, Valledor, Manuel, additional, Bustamante-Munguira, Elena, additional, Sánchez-Miralles, Ángel, additional, Peñasco, Yhivian, additional, Barberán, José, additional, Ubeda, Alejandro, additional, Amaya-Villar, Rosario, additional, Martín, María Cruz, additional, Jorge, Ruth, additional, Caballero, Jesús, additional, Marin, Judith, additional, Añón, José Manuel, additional, Sipmann, Fernando Suárez, additional, Muñiz, Guillermo, additional, Castellanos-Ortega, Álvaro, additional, Adell-Serrano, Berta, additional, Catalán, Mercedes, additional, de la Gándara, Amalia Martínez, additional, Ricart, Pilar, additional, Carbajales, Cristina, additional, Rodríguez, Alejandro, additional, Díaz, Emili, additional, de la Torre, Mari C, additional, Gallego, Elena, additional, Cantón-Bulnes, Luisa, additional, Carbonell, Nieves, additional, González, Jessica, additional, de Gonzalo-Calvo, David, additional, Barbé, Ferran, additional, and Torres, Antoni, additional

Published
2022
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30. Remdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study

Author

Gumucio-Sanguino, Víctor D., Mañez, Rafael, Solé-Violan, Jordi, de Castro, Felipe Rodríguez, Suarez-Sipmann, Fernando, García, Ruth Noemí Jorge, Aznar, María Mora, Torres, Mateu, Martinez, María, Alegre, Cynthia, Riera, Jordi, Contreras, Sofía, Pericas, Juan Manuel, Ferrer, Ricard, Caballero, Jesús, Trujillano, Javier, Vallverdú, Montse, León, Miguel, Badía, Mariona, Balsera, Begoña, Servià, Lluís, Vilanova, Judit, Rodríguez, Silvia, Montserrat, Neus, Iglesias, Silvia, Prados, Javier, Carvalho, Sula, Miralbés, Mar, Monclou, Josman, Jiménez, Gabriel, Codina, Jordi, Val, Estela, Pagliarani, Pablo, Rubio, Jorge, Morales, Dulce, Pujol, Andrés, Furro, Àngels, García, Beatriz, Torres, Gerard, Vengoechea, Javier, Gonzalo-Calvo, David de, González, Jessica, Gomez, Silvia, Gómez, José M., Franco, Nieves, Barberán, José, Albaiceta, Guillermo M, Espina, Lorena Forcelledo, Prieto, Emilio García, Vicente, Paula Martín, del Busto Martínez, Cecilia, Vidal-Cortés, Pablo, Garmendia, José Luis García, Cabello, María Aguilar, Fernández, Carmen Eulalia Martínez, Carbonell, Nieves, Cortés, María Luisa Blasco, Lázaro, Ainhoa Serrano, Díaz, Mar Juan, Ortiz, Aaron Blandino, Menendez, Rosario, Valdivia, Luis Jorge, Boado, María Victoria, Chinesta, Susana Sancho, del Carmen de la Torre, Maria, Varela, Ignacio Martínez, Vieiro, María Teresa Bouza, Arijón, Inés Esmorís, Hermoso, David Campi, Salinas, Rafaela Nogueras, Monjo, Teresa Farre, Bou, Ramon Nogue, Naya, Gregorio Marco, Barberà, Carme, Coll, Núria Ramon, Catalán-González, Mercedes, Montejo-González, Juan Carlos, Sanchez-Giron, Gloria Renedo, Bustamante-Munguira, Juan, Bustamante-Munguira, Elena, Avila, Ramon Cicuendez, Herrera, Nuria Mamolar, Almansa, Raquel, Ortega, Alicia, Bermejo-Martin, Jesús, Sagredo, Víctor, Añon, Jose, Agrifoglio, Alexander, Cachafeiro, Lucia, Maseda, Emilio, Socias, Lorenzo, Novo, Mariana Andrea, Figueras, Albert, Janer, Maria Teresa, Soliva, Laura, Ocón, Marta, Clar, Luisa, Ayestarán, J Ignacio, Peñasco, Yhivian, Fernández, Sandra Campos, Serra-Fortuny, Mireia, Forcadell-Ferreres, Eva, Salvador-Adell, Immaculada, Bofill, Neus, Adell-Serrano, Berta, Díaz, Josep Pedregosa, Casacuberta-Barberà, Núria, Urrelo-Cerrón, Luis, Piñol-Tena, Àngels, Roche-Campo, Ferran, de la Gándara, Amalia Martínez, Murúa, Pablo Ryan, Ruíz, Covadonga Rodríguez, García, Laura Carrión, Álvarez, Juan I Lazo, Lorente, José Ángel, Loza-Vázquez, Ana, Guerrero, Desire Macias, Huerta, Arturo, Tognetti, Daniel, Redruello, Carlos García, Rodríguez, David Mosquera, Fernández, Eva María Menor, Adrio, Sabela Vara, Casal, Vanesa Gómez, Pensado, Marta Segura, Vilas, María Digna Rivas, Sagastume, Amaia García, de Pablo Sánchez, Raul, Laguna, David Pestaña, Bardi, Tommaso, Villar, Rosario Amaya, Gonzalez, Carmen Gómez, Castillo, Maria Luisa Gascón, Garnacho-Montero, José, Cantón-Bulnes, María Luisa, Marin-Corral, Judith, Pérez, Cristina Carbajales, Masclans, Joan Ramon, Degracia, Ana Salazar, Bigas, Judit, Muñoz-Bermúdez, Rosana, Vilà-Vilardel, Clara, Parrilla, Francisco, Dot, Irene, Zapatero, Ana, Díaz, Yolanda, Gracia, María Pilar, Pérez, Purificación, Castellví, Andrea, Climent, Cristina, Serra, Lidia, Barbena, Laura, Cano, Iosune, Ricart, Pilar, Herraiz, Alba, Marcos, Pilar, Rodríguez, Laura, Sariñena, Maria Teresa, Sánchez, Ana, Úbeda, Alejandro, Delgado, María Cruz Martin, Gallego, Elena, Jimenez, Juan Fernando Masa, Gomà, Gemma, Díaz, Emi, Ibarz, Mercedes, De Mendoza, Diego, Barbeta, Enric, Alcaraz-Serrano, Victoria, Badia, Joan Ramon, Castella, Manuel, Bueno, Leticia, Ceccato, Adrian, Palomeque, Andrea, Barat, Laia Fernandez, Cillóniz, Catia, Conde, Pamela, Fernández, Javier, Gabarrus, Albert, Kiarostami, Karsa, López-Gavín, Alexandre, Mantellini, Cecilia L, Speziale, Carla, Vázquez, Nil, Yang, Hua, Yang, Minlan, Ferrando, Carlos, Castro, Pedro, Arrieta, Marta, Nicolas, Jose Maria, Andrea, Rut, Barroso, Marta, Pérez, Raquel, Álvarez, Sergio, Garcia-Gasulla, Dario, Tormos, Adrián, Lomas, Luis Tamayo, Aldecoa, Cesar, Herrán-Monge, Rubén, García, José Ángel Berezo, Giraudo, Pedro Enríquez, Fernández, Pablo Cardinal, López, Alberto Rubio, Pravia, Orville Báez, Messa, Juan López, Bastida, Leire Pérez, Ruiz, Antonjo Alvarez, Trenado, José, Pous, Anna Parera, Galbán, Cristóbal, Lago, Ana López, Paz, Eva Saborido, Segade, Patricia Barral, Mariño, Ana Balan, Mendez, Manuel Valledor, de Frutos, Raúl, Aguilera, Luciano, Pérez-García, Felipe, López-Ramos, Esther, Ruiz-García, Ángela Leonor, Beteré, Belén, Blancas, Rafael, Dólera, Cristina, Planelles, Gloria Perez, Peis, Enrique Marmol, Juan, Maria Dolores Martinez, Miralles, Miriam Ruiz, Rubio, Eva Perez, Martin-Montalvo, Maria Van der Hofstadt, Sánchez-Miralles, Ángel, Warrington, Tatiana Villada, Pozo-Laderas, Juan Carlos, Estrella, Angel, Cano, Sara Guadalupe Moreno, Gordo, Federico, Palacios, Basilisa Martinez, Nieto, Maite, Nieto, Maria Teresa, Ossa, Sergio, Ortega, Ana, Sanchez, Miguel, Santacoloma, Bitor, Motos, Anna, Castañeda, Tatiana, Gabarrús, Albert, Barbé, Ferran, and Torres, Antoni

Published
2023
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31. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19

Author

Victor Daniel Gumucio, Aida Monge, Adrián Ceccato, Maria del Carmen de la Torre, Amara Carratalá, Rosario Amaya Villar, Gonzalo Labarca, Anna Moncusí-Moix, Angel Estella, José Manuel Gómez, José Luis García Garmendia, María Zuil, Juan Lopez Messa, Ana Loza-Vázquez, Judith Marin-Corral, Sally Santisteve, Cristóbal Galbán, Jessica González, Paola Carmona, Jordi Solé-Violán, Pilar Ricart Martí, Carme Barberà, Ferran Barbé, Elena Bustamante-Munguira, Ignacio Martínez Varela, Ferran Roche-Campo, Cristina Carbajales, Jordi Riera, Aaron Blandino Ortiz, Iván Benítez, Arturo Huerta, David de Gonzalo-Calvo, Oscar Peñuelas, Ricard Ferrer, José Garnacho-Montero, Emili Diaz, Jesus F. Bermejo-Martin, Ana Motos, Antoni Torres, Susana Sancho Chinesta, Jesús Caballero, Luis Tamayo Lomas, Guillermo M. Albaiceta, Angel Sánchez-Miralles, Mercedes Catalán-González, Laia Fernandez, Ruth Noemí Jorge García, José Trenado, Nieves Carbonell, Yhivian Peñasco, Amalia Martínez de la Gándara, José Barberán, Rosario Menéndez, Lucía Pinilla, José M. Añón, Clara Gort-Paniello, Fernando Suares Sipmann, Mariana Andrea Novo, Elena Gallego, Gerard Torres, Dario Garcia-Gasulla, Lorenzo Socias, and Juan Carlos Pozo-Laderas

Subjects
Pulmonary and Respiratory Medicine, Mechanical ventilation, medicine.medical_specialty, ARDS, Lung, business.industry, medicine.medical_treatment, Critical Care and Intensive Care Medicine, medicine.disease, Pulmonary function testing, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, Interquartile range, Internal medicine, Diffusing capacity, Medicine, Lung volumes, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Prospective cohort study
Abstract

Background More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear. Research Question What are the major long-term pulmonary sequelae in critical patients who survive COVID-19? Study Design and Methods Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test [6MWT]), and chest CT imaging. Results One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay. Interpretation Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID-19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge.

Published
2021
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32. Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study

Author

Antoni, Torres, Ana, Motos, Catia, Cillóniz, Adrián, Ceccato, Laia, Fernández-Barat, Albert, Gabarrús, Jesús, Bermejo-Martin, Ricard, Ferrer, Jordi, Riera, Raquel, Pérez-Arnal, Dario, García-Gasulla, Oscar, Peñuelas, José Ángel, Lorente, David, de Gonzalo-Calvo, Raquel, Almansa, Rosario, Menéndez, Andrea, Palomeque, Rosario Amaya, Villar, José M, Añón, Ana, Balan Mariño, Carme, Barberà, José, Barberán, Aaron, Blandino Ortiz, Maria Victoria, Boado, Elena, Bustamante-Munguira, Jesús, Caballero, María Luisa, Cantón-Bulnes, Cristina, Carbajales Pérez, Nieves, Carbonell, Mercedes, Catalán-González, Raul, de Frutos, Nieves, Franco, Cristóbal, Galbán, Víctor D, Gumucio-Sanguino, Maria Del Carmen, de la Torre, Emili, Díaz, Ángel, Estella, Elena, Gallego, José Luis, García Garmendia, José M, Gómez, Arturo, Huerta, Ruth Noemí Jorge, García, Ana, Loza-Vázquez, Judith, Marin-Corral, María Cruz, Martin Delgado, Amalia, Martínez de la Gándara, Ignacio, Martínez Varela, Juan, López Messa, Guillermo M, Albaiceta, Maite, Nieto, Mariana Andrea, Novo, Yhivian, Peñasco, Felipe, Pérez-García, Juan Carlos, Pozo-Laderas, Pilar, Ricart, Victor, Sagredo, Angel, Sánchez-Miralles, Susana, Sancho Chinesta, Mireia, Serra-Fortuny, Lorenzo, Socias, Jordi, Solé-Violan, Fernando, Suarez-Sipmann, Luis, Tamayo Lomas, José, Trenado, Alejandro, Úbeda, Luis Jorge, Valdivia, Pablo, Vidal, Ferran, Barbé, and Bitor, Santacoloma

Subjects
Infecciones por coronavirus, Critical Illness, Enfermedad transmisible, COVID-19, Critical Care and Intensive Care Medicine, Respiration, Artificial, COVID-19 Drug Treatment, Tratamiento médico, Intensive Care Units, Adrenal Cortex Hormones, Intensive care, Corticosteroids, Humans, Steroids, Precision Medicine, Critically ill
Abstract

Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19. Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment (< 7 days since symptom onset) and long term of corticosteroids (≥ 10 days) were also investigated. Results: Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p < 0.001). Significant effect modification was found after adjustment for covariates using propensity score for age (p = 0.001 interaction term), Sequential Organ Failure Assessment (SOFA) score (p = 0.014 interaction term), and mechanical ventilation (p = 0.001 interaction term). We observed a beneficial effect of corticosteroids on 90-day mortality in various patient subgroups, including those patients aged ≥ 60 years; those with higher baseline severity; and those receiving invasive mechanical ventilation at ICU admission. Early administration was associated with a higher risk of 90-day mortality in the overall population (HR 1.32 [1.14-1.53], p < 0.001). Long-term use was associated with a lower risk of 90-day mortality in the overall population (HR 0.71 [0.61-0.82], p < 0.001). No effect was found regarding the dosage of corticosteroids. Moreover, the use of corticosteroids was associated with an increased risk of nosocomial bacterial pneumonia and hyperglycaemia. Conclusion: Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful. Instituto de Salud Carlos III de Madrid (ISCIII) (COV20/00110) Centro de Investigacion Biomedica En Red-Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III European Commission Miguel Servet 2020: CP20/00041 Instituto de Salud Carlos III (PI19/00207) 41.787 JCR (2022) Q1, 2/35 Critical Care Medicine 4.344 SJR (2022) Q1, 2/98 Critical Care and Intensive Care Medicine No data IDR 2022 UEM

Published
2022

33. Portable Low Coherence Digital Holographic Microscope

Author

Miguel León-Rodrguez, juan Rayas, Amalia Martínez-García, Adrian Martínez-González, Israel Migue-Andrés, Alejandro Téllez-Quiñones, and Fernando Mendoza Santoyo

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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34. Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease

Author

Tejerina E. E., Pelosi P., Robba C., Penuelas O., Muriel A., Barrios D., Frutos-Vivar F., Raymondos K., Du B., Thille A. W., Rios F., Gonzalez M., Del-Sorbo L., Marin M. D. C., Valle Pinheiro B., Soares M. A., Nin N., Maggiore S. M., Bersten A., Amin P., Cakar N., Young Suh G., Abroug F., Jibaja M., Matamis D., Ali Zeggwagh A., Sutherasan Y., Anzueto A., Esteban A, Fernando Ríos, Damian Violi, Marisol Rodríguez-Goñi, Roger Lamoglie, Fernando Villarejo, Norberto Tiribelli, Santiago Ilutovich, Matías Brizuela, Mariana Monllau, Fernando Saldarini, Silvina Borello, Alberto Marino, Mauricio Vinzio, Karina Bonasegla, Julián Hernández, María Belén Yapur, María Eugenia González, Sebastián E Mare, Judith Sagardía, Marco Bezzi, Cecilia Pereyra, Julian Strati, Daniel Vargas, Claudia Diaz, Pablo Gómez, Marcelo Palavecino, Graciela Elizabeth, Aguilera García, M Eugenia, Luis Pablo Cardonnet, Lisandro Betttini, Hernán Nuñez, Lucas Vallejo, Fernando Fernández, Jorge Arroyo, Daniel Duarte, Gerardo Filippa, Cayetano Galetti, Hernan Nunia, Fernando Lambert, Elisa Estenssoro, Marina Busico, Javier Horacio Álvarez, Alejandro Raimondi, Gustavo Badariotti, Martín Lugaro, Fernando Lipovestky, Alan Javier Zazu, Hugo Capponcelli, Patricia Vogl, Cristina Orlandi, Alejandro Gómez, Gustavo Jannello, Alejandro Risso, Leticia Rapetti, Guillermo Chiappero, Juan Domingo Fernández, Rodrigo E Gómez-Paz, Marcos Juan Zec, Pascual Valdez, Jorgelina Guyon, Ariel Chena, Sergio Lasdica, Martin Deheza, Schimdt Alejandra, Francisco Criado, Norma Beatriz Márquez, Pablo Desmery, José Luis Scapellato, Gonzalo Javier Ríos, Cristian Casabella, Jasmin Board, Andrew Davies, Andrew Bersten, Elisha Matheson, Amy Waters, John Santamaria, Jennifer Holmes, Cartan Costello, Manoj K Saxena, John Myburgh, Ellen Kinkel, Forbes McGain, Claire Cattigan, Allison Bone, Ian Seppelt, Leonie Weisbrodt, Cheryl Cuzner, Christopher MacIsaac, Deborah Barge, Tania Caf, Cameron Knott, Graeme Duke, Imogen Mitchell, Helen Rodgers, Rachel Whyte, Elisha Fulton, Alistair Nichol, Hergen Buscher, Priya Nair, Claire Reynolds, Simon J G Hockley, Ian Moore, Katherine Davidson, David Milliss, Raju Pusapati, Helen Wong, Jason Fletcher, Julie Smith, Paul Goldrick, Dianne Stephens, Jane Thomas, Anders Aneman, Sutrisno Gunawan, Tom Cowlam, George Lukas, Rick McAllister, Minka Springham, Joanne Sutton, Jeff Presneill, Tony Sutherland, Dianne Hill, Howard Connor, Jenny Dennett, Tim Coles, Freddy Sandy, Sando Chavarria, Marcelo Choque, Ronald Pairumani, Juan Guerra, Marco Antônio Soares Reis, José Carlos Versiani, Eduardo Fonseca Sad, Maria Aparecida Braga, Dinalva Aparecida Gomes, Fernando Antônio Botoni, Maurício Meireles Góes, Frederico Costa Val Barros, Rogério de Castro Pereira, Hugo Urbano, Valéria de Carvalho Magela, Aline Camile Yehia, Bruno Bonaccorsi Fernandino, Marco Antônio Ribeiro Leão, Rovílson Lara, Rubens Altair Amaral de Pádua, Janine Dias Alves, Aloísio Marques do Nascimento, Bruno do Valle Pinheiro, Carlos Alberto Studart Gomes, Marcelo Alcântara Holanda, Frederico Rodrigues Anselmo, Niall Ferguson, Neill Adhikari, Robert Fowler, Cheromi Sittambalam, Mehar-Un-Nisa Raja, Nicole Marinoff, Lauralyn McIntryre, Shawna Reddie, Laura Jones, Irene Watpool, Jeffrey Singh, Madison Dennis, Andrea Matte, Marc Lipkus, Ryan Albert, Andrew Steel, Emily Stern, Michael Miletin, Antonio Raso, Robyn Klages, Jan Friedrich, Orla Smith, Laura Wilson, Deborah Cook, Mark Bailey, Sangeeta Mehta, Stephen Lapinsky, Hannah Mathers, Cheryl Ethier, Stephanie Lubchansky, Samer Haj-Bakri, Dietrich Henzler, Lisa Julien, Luis Soto-Román, Juan Carlos Maurelia, César Antonio Maquilon, Luis Soto-Germani, Bin Du, Yan Kang, Bo Wang, Fachun Zhou, Fang Xu, Haibo Qiu, Yi Yang, Qingyuan Zhan, Bing Sun, Zhenjie Hu, Bin Yu, Xi Zhu, Yu Bai, Gang Li, Yi Li, Geng Zhang, Jianbiao Meng, Xiaobo Huang, Hong Pu, Daxing Yu, Chuanyun Qian, Wei Zhang, Yongjie Yin, Debiao Song, Yunxuan Yue, Zhengxuan Lv, Chengmin Yu, Qunmei Yao, Xue Wang, Yuan Xu, Wei He, Mian Chen, Zhihua Hu, Dongpo Jiang, Jian Huang, Wei Yu, Juanxian Gu, Yangong Chao, Zhixiang Li, Zhicheng Zhang, Wanxia Li, Zhenyang He, Jianguo Li, Chang Liu, Tiehe Qin, Shouhong Wang, Feng Li, Jun Jin, Jianhong Fu, Hongyang Xu, Hongyuan Lin, Jianying Guo, Yalin Liu, Jinghua Wang, Maoqin Li, Jiaqiong Li, Lei Chen, Qing Song, Liang Pan, Xianyao Wan, Jiuzhi Zhang, Weihai Yao, Yuhong Guo, Pang Wing Yan, Kelly Choy, Kwan Ming Chit, Patricia Leung, Chau Chin Man, Marco González, Ricardo Buitrago, Marcela Granados, Guillermo Ortiz, Cesar Enciso, Mario Gómez, Bladimir Alejandro Gil, Juan Pablo Sedano, Luis Fernando Castro Castro, Carlo Alberto Acosta, Marco Gonzalez, Francisco Molina, Camilo Pizarro, Mario Villabon, Carmelo Dueñas, Carlos Andrés Díaz, Nelson Fonseca, Rubén Camargo, Juan David Uribe, Hans-Henrik Bülow, Simona Beniczky, Jens Brushoj, Mikkel Præst, Birgitte Viebaek, Sine Wichman, Anette Mortensen, Susanne Andi Iversen, Bo Broberg, Edgard Luna, Manuel Jibaja, Leonardo Pazmiño, Katty Trelles, Fabricio Picoita, Gustavo Paredes, Vanesa Ramírez, Guillermo Falconí, Cristian Cevallos, Boris Villamagua, Marco Escobar, Freddy Sánchez, Miguel Llano, Miguel Lazcano, Ramiro Puetate, José Miguel Guerrero, Mijail Játiva, Myriam Montalvo, Franklin Villegas, Luis González Zambrano, Ronnie Mantilla, Gina Quinde, Andrea Gimenez, Luis Gonzalez Mosquera, Henry Caballero, María Fernanda García, Marcelo Ochoa, Soraya Puertas, Jackeline Coello, Mario Acosta, Medhat Soliman, Arnaud W Thille, Achille Kouatchet, Alain Mercat, Laurent Brochard, François Collet, Guillaume Marcotte, Pascal Beuret, Jean-Christophe M Richard, Gaëtan Bedunaeu, Pierre-Gildas Guitard, Fabien Soulis, Frédéric Bellec, Philippe Berger, Dorothée Carpentier, Benoit Veber, Salem Ould Zein, Géraldine Dessertaine, C Canevet, Fabien Grelon, Konstantinos Raymondos, Rolf Dembinski, Rolf Rossaint, Steffen Weber-Carstens, Christian Putensen, Maximillian Ragaller, Michael Quintel, Winfried Schubert, Thomas Bein, Heinrich Paulus, Walter Brandt, Lutz Pfeiffer, Silke Frenzel, Thoralf Kerner, P Kruska, Leila Eckholt, Joachim Hartung, Harald Fritz, Monika Holler, Johannes Busch, Andreas Viehöfer, Jens Buettner, Jörn Schlechtweg, Achim Lunkeit, Roland Schneider, Maria Wussow, Nils Marquardt, Christian Frenkel, Falk Hildebrandt, Tumbass Volker, Thomas Lipp, Cezar Mihailescu, Thomas Moellhoff, Thomas Steinke, Oliver Franke, Marcus Ruecker, Markus Schappacher, Steffen Appel, Heinz Kerger, Andreas Schwartz, Jan Dittmann, Jörg Haberkorn, Wolfgang Baier, Walter Seyde, Dimitros Matamis, Eleni Antoniadou, Pertsas Evangelos, Maria Giannakou, Zoltan Szentkereszty, Zsolt Molnar, Pravin Amin, Farhad N Kapadia, Nagarajan Ramakrishnan, Deepak Govil, Anitha Shenoy, Umesh G, Samir Sahu, Sheila Nainan Myatra, Subhash Kumar Todi, Sanjay Dhanuka, Mayur Patel, P Samaddar, Dhruva Chaudhry, Vivek Joshi, Srinivas Samavedam, Ankur Devendra Bhavsar, Prachee Sathe, Sujoy Mukherjee, Salvatore Maurizio Maggiore, Francesco Idone, Federica Antonicelli, Paolo Navalesi, Rosanna Vaschetto, Arianna Boggero, Rosalba Tufano, Michele Iannuzzi, Edoardo De Robertis, Romano Tetamo, Andrea Neville Cracchiolo, Antonio Braschi, Francesco Mojoli, Ilaria Curro', Mirko Belliato, Chiara Verga, Marta Ferrari, Erika Mannelli, Valerio Mangani, Giorgio Tulli, Francesca Frigieri, Armando Pedulla', Monica Rocco, Giorgia Citterio, Di Russo, Gaetano Perchiazzi, Loredana Pitagora, Antonio Pesenti, Michela Bombino, Davide Chiumello, Federica Tallarini, Serena Azzari, Antonina Pigna, Ivano Aprile, Marco Adversi, Antonio Corcione, Marianna Esposito, Annunziata Mattei, Vito Marco Ranieri, Rosario Urbino, Ilaria Maria Mastromauro, Antonino Giarratano, Maurizio Raineri Santi, Ambrogio Sansone, Younsuck Koh, Moo Suk Park, Je Hyeong Kim, Kyung Chan Kim, Hye Sook Choi, Yun Seong Kim, Jin Hwa Lee, Myung-Goo Lee, Won-Yeon Lee, Jin Young An, Gee Young Suh, Ki-Suck Jung, Asisclo J Villagómez Ortiz, César Cruz Lozano, Zalatiel Maycotte Luna, José Francisco López Baca, José Elizalde, Guillermo Cueto Robledo, Mario Alonso Treviño Salinas, Ricardo Martinez Zubieta, Claudia Olvera-Guzman, Marco Montes De Oca, Silvio A Ñamendys-Silva, José Salvador Martínez Cano, Jose Angel Baltazar Torres, Gustavo Morales Muñoz, Antonio Villa Delgado, Javier Ladape Martinez, Amine Ali Zeggwagh, Tarek Dendane, Abderrahim Azzouzi, Ahmed Sbihi, Wajdi Maazouzi, Mourad Amor, Charki Haimeur, Michael A Kuiper, Matty Koopmans, Uli Strauch, Dennis Bergmans, Serge Heines, Sylvia den Boer, Bas M Kors, Peter van der Voort, Paul J Dennesen, Bert Beishuizen, Ingrid van den Hul, Erna Alberts, Harry P P M Gelissen, Eduard Bootsma, Auke Reidinga, Kim Heus, Diane Mackle, Paul Young, Rachael Parke, Eileen Gilder, Jodi Brown, Lynette Newby, Catherine Simmonds, Jan Mehrtens, Seton Henderson, Tony Williams, Judi Tai, Chantal Hogan, Mary La Pine, John Durning, Sheree Gare, Troy Browne, Shirley Nelson, Jennifer Goodson, Julio Osorio, Chabu Coronado, Rollin Roldán Mori, Rosa Luz López Martínez, Adam Mikstacki, Barbara Tamowicz, Rui Moreno, Eduardo Almeida, Joana Silvestre, Heloisa Castro, Irene Aragão, Susana Alves Ferreira, Nelson Barros, Filomena Faria, Carlos André Correia Casado, Fausto Fialho Moura, Paulo Marcal, Ricardo Matos, Edward Nicolayenko, Mikhail Kirov, Andrey Yaroshetskiy, Andrei Piontek, Valery Subbotin, Yaseen Arabi, Olivia Dulfo, Chafrina Marie Olay, Edgardo E Tabhan, Nicolas Nin, Alfonso Muñoz, César Aragón, Ana Villagrá, Ainhoa Rosselló, Joan Maria Raurich, María Garitacelaya, Miguel Ángel González-Gallego, Francisco Ortuño, Miguel Fernández-Vivas, David Freire, Francisco Guerrero, Francisco Manzano, Juan Carlos, Alfredo Padrón, Pedro Rosa, Rafael Morales, Liliana Caipe, Maurizio Bottiroli, José María Nicolás, Marta Ugalde, Javier Ruiz, Lucia Capilla, Guillermo Muñiz, Jesús Sánchez-Ruiz, Javier Cebrián, Begoña Balerdi, Elena Parreño, Alvaro van Bommel, César Pérez-Calvo, Irene Dot, Javier Blanco, Raquel Manzanedo, José J Blanco, Daniel Fontaneda, Raúl González, Javier Díaz Domínguez, Alfonso Moreno, Antonio Reyes, Ian Carrasco, Itziar Mintegui, Rosa Sebastián, Javier García-Alonso, Carolina Lorencio, Josep Maria Sirvent, Patricia Jimeno, Miguel León, Pedro Galdos, Nuria Alonso, Julia López-Díaz, María Victoria de la Torre, Jorge Vidal Hernández, Nicolás Zamboschi, Francisco Lucena, Gemma Rialp, Raquel Montoiro, Victoria Goñi, María Ángeles Pena, Antonio Maestre, Marc Fabra, Jacinto Baena, Eva Benveniste, Susana Temprano, Jesús Sánchez, Carmen Campos, Sara Cabañes, María Elena Pérez-Losada, José Claudio Leo, Enrique Piacentini, María Del Carmen de la Torre, Laura Álvarez-Montero, Fernando Sánchez, Antonio Viñuales, Bernabé Álvarez, Javier Castañeda, Ángela Alonso, María Isabel Ruiz, Pedro Jesús Domínguez, Marcos Delgado, Eugenio Palazón, Antonio García-Jiménez, Rosa Álvaro, Clara Laplaza Eva Regidor, Enrique Maraví, José María Quiroga, Amalia Martínez de la Gandara, Cecilia Carbayo, María Luisa Navarrete, Manuel Valledor, Raquel Yano, José María Gutiérrez, Javier González-Robledo, Amparo Ferrandiz, Alberto Belenguer, Lidón Mateu, Laura Sayagues, María José Tolón, Nieves Franco, Elena Gallego, Félix Lacoma, Patricia Albert, Vicente Arraez, Mar Gobernado, Susana Moradillo, Carolina Gímenez-Esparza, Teresa Sánchez de Dios, Carlos Marian Crespo, Cecilia Hermosa, Federico Gordo, Genis Carrasco, María Ángeles Alonso, Alejandro Algora, Raúl de Pablo, Sofía García, Ana Carolina Caballero, José María Montón, Teresa Mut, Eva Manteiga, Alejandro de la Serna, Ana Esther Trujillo, Rafael Blancas, Inmaculada Vallverdú, José Manuel Serrano, Miquel Ferrer, Juan Diego Jiménez, Carlos Gallego, Dolores Vila, Luis Marina, Valentín Parra, Juan Ramón Cortés, Chen Chin-Ming, Ai-Chin Cheng, Fekri Abroug, Besbes Mohamed, Imed Chouchene, Mounir Bouaziz, Stambouli Neji, Islem Ouanes, Ayed Samia, Nahit Cakar, Ismail Kati, Ali Aydım Altunkan, Remzi Iscimen, Zafer Dogan, Bilge Çetin, Tayfun Adanir, Sabriye Guvenc, Unase Büyükkoçak, Antonio Anzueto, Ashley Ellis, Gary Kinasewitz, Allan Walkey, Phil Alkana, Gregory A Schmidt, Susan Gillen, Kathleen Lilli, Jennifer Twombley, Denice Wells, Larry Welder, Alejandro Arroliga, Alfredo Vasquez-Sandoval, Vincent John Scott, Craig Cernosek, Christopher Spradley, Dimple Tejwani, Sindhaghatta Venkatram, Gilda Diaz-Fuentes, Amber Monson, Anthony Saleh, Madhav Gudi, George Liziamma, Mohamed A Saad, Crissie De Spirito, Bryan Beatty, Samir Vermani, Crissie Despirito, Zaza Cohen, Amee Patrawalla, Samir Abdelhadi, Rupesh Vakil, Steven Y Chang, Brian Sherman, Rosanna Del Giudice, John Oropell, Timothy D Girard, Cayce Strength, Joyce Okahashi, Leanne Boehm, Matthew Kirchner, Erwin J Oei, Sebastian Circo, Nelson Medina, Mohammed Al-Jagbeer, V J Cardenas Jr, Smyth Smith, Shelby Sutton, Marcela Canola-Mazo, Tim Houlihan, Yogeet Kaur, Travis Parry, Craig A Piquette, Kerry Canady, Rahul Nanchal, Dana K Soetaert, Maria Del Mar Torres-Perez, Carlos Robles-Arias, William Rodriguez-Cintron, Mark Tidswell, Jennifer Germain, Lori-Ann Kozikowski, Erin Braden, Geneva Tatem, Javier Hurtado, Alberto Deicas, Daniel Weiss, Marta Beron, Román Garrido, Cristina Santos, Mario Cancela, Raúl Lombardi, Pedro Alzugaray, Jorge Gerez, Silvia Mareque, Graciela Franca, Oscar Cluzet, Edgardo Nuñez, Julio Pontet, Sergio Cáceres, Elias Caragna, Alberto Soler, Frank Torres, Gastón Pittini, Gabriel D Empaire, Stevens Salva, Fernando Pérez, Clara Pacheco, Zoraida Parra, Ingrid Von der Osten, Luis Williams, José Salinas, Do Danh Quynh, Pham Thi Van Anh, Nguyen Huu Hoang, Nghuyen Ba Tuan, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Arts Assistenten IC (9), Intensive Care, MUMC+: MA Medische Staf IC (9), Tejerina E.E., Pelosi P., Robba C., Penuelas O., Muriel A., Barrios D., Frutos-Vivar F., Raymondos K., Du B., Thille A.W., Rios F., Gonzalez M., Del-Sorbo L., Marin M.D.C., Valle Pinheiro B., Soares M.A., Nin N., Maggiore S.M., Bersten A., Amin P., Cakar N., Young Suh G., Abroug F., Jibaja M., Matamis D., Ali Zeggwagh A., Sutherasan Y., Anzueto A., Esteban A, and Fernando Ríos, Damian Violi, Marisol Rodríguez-Goñi, Roger Lamoglie, Fernando Villarejo, Norberto Tiribelli, Santiago Ilutovich, Matías Brizuela, Mariana Monllau, Fernando Saldarini, Silvina Borello, Alberto Marino, Norberto Tiribelli, Mauricio Vinzio, Karina Bonasegla, Julián Hernández, María Belén Yapur, María Eugenia González, Sebastián E Mare, Judith Sagardía, Marco Bezzi, Cecilia Pereyra, Julian Strati, Daniel Vargas, Claudia Diaz, Pablo Gómez, Marcelo Palavecino, Graciela Elizabeth, Aguilera García, M Eugenia, Luis Pablo Cardonnet, Lisandro Betttini, Hernán Nuñez, Lucas Vallejo, Fernando Fernández, Jorge Arroyo, Daniel Duarte, Gerardo Filippa, Cayetano Galetti, Hernan Nunia, Fernando Lambert, Elisa Estenssoro, Marina Busico, Fernando Villarejo, Javier Horacio Álvarez, Alejandro Raimondi, Gustavo Badariotti, Martín Lugaro, Fernando Lipovestky, Alan Javier Zazu, Hugo Capponcelli, Patricia Vogl, Cristina Orlandi, Alejandro Gómez, Gustavo Jannello, Alejandro Risso, Leticia Rapetti, Guillermo Chiappero, Juan Domingo Fernández, Rodrigo E Gómez-Paz, Marcos Juan Zec, Pascual Valdez, Jorgelina Guyon, Ariel Chena, Sergio Lasdica, Martin Deheza, Schimdt Alejandra, Francisco Criado, Norma Beatriz Márquez, Pablo Desmery, José Luis Scapellato, Gonzalo Javier Ríos, Cristian Casabella, Jasmin Board, Andrew Davies, Andrew Bersten, Elisha Matheson, Amy Waters, John Santamaria, Jennifer Holmes, Cartan Costello, Manoj K Saxena, John Myburgh, Ellen Kinkel, Forbes McGain, Claire Cattigan, Allison Bone, Ian Seppelt, Leonie Weisbrodt, Cheryl Cuzner, Christopher MacIsaac, Deborah Barge, Tania Caf, Cameron Knott, Graeme Duke, Imogen Mitchell, Helen Rodgers, Rachel Whyte, Elisha Fulton, Jasmin Board, Andrew Davies, Alistair Nichol, Hergen Buscher, Priya Nair, Claire Reynolds, Simon J G Hockley, Ian Moore, Katherine Davidson, David Milliss, Raju Pusapati, Helen Wong, Jason Fletcher, Julie Smith, Paul Goldrick, Dianne Stephens, Jane Thomas, Anders Aneman, Sutrisno Gunawan, Tom Cowlam, George Lukas, Rick McAllister, Minka Springham, Joanne Sutton, Jeff Presneill, Tony Sutherland, Dianne Hill, Howard Connor, Jenny Dennett, Tim Coles, Freddy Sandy, Sando Chavarria, Marcelo Choque, Ronald Pairumani, Juan Guerra, Marco Antônio Soares Reis, José Carlos Versiani, Eduardo Fonseca Sad, Maria Aparecida Braga, Dinalva Aparecida Gomes, Fernando Antônio Botoni, Maurício Meireles Góes, Frederico Costa Val Barros, Rogério de Castro Pereira, Hugo Urbano, Valéria de Carvalho Magela, Aline Camile Yehia, Bruno Bonaccorsi Fernandino, Marco Antônio Ribeiro Leão, Rovílson Lara, Rovílson Lara, Rubens Altair Amaral de Pádua, Janine Dias Alves, Aloísio Marques do Nascimento, Bruno do Valle Pinheiro, Carlos Alberto Studart Gomes, Marcelo Alcântara Holanda, Frederico Rodrigues Anselmo, Niall Ferguson, Neill Adhikari, Robert Fowler, Cheromi Sittambalam, Mehar-Un-Nisa Raja, Nicole Marinoff, Lauralyn McIntryre, Shawna Reddie, Laura Jones, Irene Watpool, Jeffrey Singh, Madison Dennis, Andrea Matte, Marc Lipkus, Ryan Albert, Andrew Steel, Emily Stern, Michael Miletin, Antonio Raso, Robyn Klages, Jan Friedrich, Orla Smith, Laura Wilson, Deborah Cook, Mark Bailey, Sangeeta Mehta, Stephen Lapinsky, Hannah Mathers, Cheryl Ethier, Stephanie Lubchansky, Samer Haj-Bakri, Dietrich Henzler, Lisa Julien, Luis Soto-Román, Juan Carlos Maurelia, César Antonio Maquilon, Luis Soto-Germani, Bin Du, Yan Kang, Bo Wang, Fachun Zhou, Fang Xu, Haibo Qiu, Yi Yang, Qingyuan Zhan, Bing Sun, Zhenjie Hu, Bin Yu, Xi Zhu, Yu Bai, Gang Li, Yi Li, Geng Zhang, Jianbiao Meng, Xiaobo Huang, Hong Pu, Bin Du, Daxing Yu, Chuanyun Qian, Wei Zhang, Yongjie Yin, Debiao Song, Yunxuan Yue, Zhengxuan Lv, Chengmin Yu, Qunmei Yao, Xue Wang, Yuan Xu, Wei He, Mian Chen, Zhihua Hu, Dongpo Jiang, Jian Huang, Wei Yu, Juanxian Gu, Yangong Chao, Zhixiang Li, Zhicheng Zhang, Wanxia Li, Zhenyang He, Jianguo Li, Chang Liu, Tiehe Qin, Shouhong Wang, Feng Li, Jun Jin, Jianhong Fu, Hongyang Xu, Hongyuan Lin, Jianying Guo, Yalin Liu, Jinghua Wang, Maoqin Li, Jiaqiong Li, Lei Chen, Qing Song, Liang Pan, Xianyao Wan, Jiuzhi Zhang, Weihai Yao, Yuhong Guo, Pang Wing Yan, Kelly Choy, Kwan Ming Chit, Patricia Leung, Chau Chin Man, Marco González, Ricardo Buitrago, Marcela Granados, Guillermo Ortiz, Cesar Enciso, Mario Gómez, Bladimir Alejandro Gil, Juan Pablo Sedano, Luis Fernando Castro Castro, Carlo Alberto Acosta, Marco Gonzalez, Francisco Molina, Camilo Pizarro, Mario Villabon, Carmelo Dueñas, Carlos Andrés Díaz, Nelson Fonseca, Rubén Camargo, Juan David Uribe, Hans-Henrik Bülow, Simona Beniczky, Jens Brushoj, Mikkel Præst, Birgitte Viebaek, Sine Wichman, Anette Mortensen, Susanne Andi Iversen, Bo Broberg, Edgard Luna, Manuel Jibaja, Leonardo Pazmiño, Katty Trelles, Fabricio Picoita, Gustavo Paredes, Vanesa Ramírez, Guillermo Falconí, Cristian Cevallos, Boris Villamagua, Marco Escobar, Freddy Sánchez, Miguel Llano, Miguel Lazcano, Ramiro Puetate, José Miguel Guerrero, Mijail Játiva, Myriam Montalvo, Franklin Villegas, Luis González Zambrano, Ronnie Mantilla, Gina Quinde, Andrea Gimenez, Luis Gonzalez Mosquera, Henry Caballero, María Fernanda García, Marcelo Ochoa, Soraya Puertas, Jackeline Coello, Mario Acosta, Medhat Soliman, Arnaud W Thille, Achille Kouatchet, Alain Mercat, Laurent Brochard, François Collet, Guillaume Marcotte, Pascal Beuret, Jean-Christophe M Richard, Gaëtan Bedunaeu, Pierre-Gildas Guitard, Fabien Soulis, Frédéric Bellec, Philippe Berger, Dorothée Carpentier, Benoit Veber, Salem Ould Zein, Géraldine Dessertaine, C Canevet, Fabien Grelon, Konstantinos Raymondos, Rolf Dembinski, Rolf Rossaint, Steffen Weber-Carstens, Christian Putensen, Maximillian Ragaller, Michael Quintel, Winfried Schubert, Thomas Bein, Heinrich Paulus, Walter Brandt, Lutz Pfeiffer, Silke Frenzel, Thoralf Kerner, P Kruska, Leila Eckholt, Joachim Hartung, Harald Fritz, Monika Holler, Johannes Busch, Andreas Viehöfer, Jens Buettner, Jörn Schlechtweg, Achim Lunkeit, Roland Schneider, Maria Wussow, Nils Marquardt, Christian Frenkel, Falk Hildebrandt, Tumbass Volker, Thomas Lipp, Cezar Mihailescu, Thomas Moellhoff, Thomas Steinke, Oliver Franke, Marcus Ruecker, Markus Schappacher, Steffen Appel, Heinz Kerger, Andreas Schwartz, Jan Dittmann, Jörg Haberkorn, Wolfgang Baier, Walter Seyde, Dimitros Matamis, Eleni Antoniadou, Pertsas Evangelos, Maria Giannakou, Zoltan Szentkereszty, Zsolt Molnar, Pravin Amin, Farhad N Kapadia, Nagarajan Ramakrishnan, Deepak Govil, Anitha Shenoy, Umesh G, Samir Sahu, Sheila Nainan Myatra, Subhash Kumar Todi, Sanjay Dhanuka, Mayur Patel, P Samaddar, Dhruva Chaudhry, Vivek Joshi, Srinivas Samavedam, Ankur Devendra Bhavsar, Prachee Sathe, Sujoy Mukherjee, Salvatore Maurizio Maggiore, Francesco Idone, Federica Antonicelli, Paolo Navalesi, Rosanna Vaschetto, Arianna Boggero, Rosalba Tufano, Michele Iannuzzi, Edoardo De Robertis, Romano Tetamo, Andrea Neville Cracchiolo, Antonio Braschi, Francesco Mojoli, Ilaria Curro', Mirko Belliato, Chiara Verga, Marta Ferrari, Erika Mannelli, Valerio Mangani, Giorgio Tulli, Francesca Frigieri, Armando Pedulla', Monica Rocco, Giorgia Citterio, Di Russo, Gaetano Perchiazzi, Loredana Pitagora, Antonio Pesenti, Michela Bombino, Davide Chiumello, Federica Tallarini, Serena Azzari, Antonina Pigna, Ivano Aprile, Marco Adversi, Antonio Corcione, Marianna Esposito, Annunziata Mattei, Vito Marco Ranieri, Rosario Urbino, Ilaria Maria Mastromauro, Antonino Giarratano, Maurizio Raineri Santi, Ambrogio Sansone, Younsuck Koh, Moo Suk Park, Je Hyeong Kim, Kyung Chan Kim, Hye Sook Choi, Yun Seong Kim, Jin Hwa Lee, Myung-Goo Lee, Won-Yeon Lee, Jin Young An, Gee Young Suh, Ki-Suck Jung, Asisclo J Villagómez Ortiz, César Cruz Lozano, Zalatiel Maycotte Luna, José Francisco López Baca, José Elizalde, Guillermo Cueto Robledo, Mario Alonso Treviño Salinas, Ricardo Martinez Zubieta, Claudia Olvera-Guzman, Marco Montes De Oca, Silvio A Ñamendys-Silva, José Salvador Martínez Cano, Jose Angel Baltazar Torres, Gustavo Morales Muñoz, Antonio Villa Delgado, Javier Ladape Martinez, Amine Ali Zeggwagh, Tarek Dendane, Abderrahim Azzouzi, Ahmed Sbihi, Wajdi Maazouzi, Mourad Amor, Charki Haimeur, Michael A Kuiper, Matty Koopmans, Uli Strauch, Dennis Bergmans, Serge Heines, Sylvia den Boer, Bas M Kors, Peter van der Voort, Paul J Dennesen, Bert Beishuizen, Ingrid van den Hul, Erna Alberts, Harry P P M Gelissen, Eduard Bootsma, Auke Reidinga, Jasmin Board, Andrew Davies, Kim Heus, Diane Mackle, Paul Young, Rachael Parke, Eileen Gilder, Jodi Brown, Lynette Newby, Catherine Simmonds, Jan Mehrtens, Seton Henderson, Tony Williams, Judi Tai, Chantal Hogan, Mary La Pine, John Durning, Sheree Gare, Troy Browne, Shirley Nelson, Jennifer Goodson, Julio Osorio, Chabu Coronado, Rollin Roldán Mori, Rosa Luz López Martínez, Adam Mikstacki, Barbara Tamowicz, Rui Moreno, Eduardo Almeida, Joana Silvestre, Heloisa Castro, Irene Aragão, Susana Alves Ferreira, Nelson Barros, Filomena Faria, Carlos André Correia Casado, Fausto Fialho Moura, Paulo Marcal, Ricardo Matos, Edward Nicolayenko, Mikhail Kirov, Andrey Yaroshetskiy, Andrei Piontek, Valery Subbotin, Yaseen Arabi, Olivia Dulfo, Chafrina Marie Olay, Edgardo E Tabhan, Nicolas Nin, Alfonso Muñoz, César Aragón, Ana Villagrá, Ainhoa Rosselló, Joan Maria Raurich, María Garitacelaya, Miguel Ángel González-Gallego, Francisco Ortuño, Miguel Fernández-Vivas, David Freire, Francisco Guerrero, Francisco Manzano, Juan Carlos, Alfredo Padrón, Pedro Rosa, Rafael Morales, Liliana Caipe, Maurizio Bottiroli, José María Nicolás, Marta Ugalde, Javier Ruiz, Lucia Capilla, Guillermo Muñiz, Jesús Sánchez-Ruiz, Javier Cebrián, Begoña Balerdi, Elena Parreño, Alvaro van Bommel, César Pérez-Calvo, Irene Dot, Javier Blanco, Raquel Manzanedo, José J Blanco, Daniel Fontaneda, Raúl González, Javier Díaz Domínguez, Alfonso Moreno, Antonio Reyes, Ian Carrasco, Itziar Mintegui, Rosa Sebastián, Javier García-Alonso, Carolina Lorencio, Josep Maria Sirvent, Patricia Jimeno, Miguel León, Pedro Galdos, Nuria Alonso, Julia López-Díaz, María Victoria de la Torre, Jorge Vidal Hernández, Nicolás Zamboschi, Francisco Lucena, Gemma Rialp, Raquel Montoiro, Victoria Goñi, María Ángeles Pena, Antonio Maestre, Marc Fabra, Jacinto Baena, Eva Benveniste, Susana Temprano, Jesús Sánchez, Carmen Campos, Sara Cabañes, María Elena Pérez-Losada, José Claudio Leo, Enrique Piacentini, María Del Carmen de la Torre, Laura Álvarez-Montero, Fernando Sánchez, Antonio Viñuales, Bernabé Álvarez, Javier Castañeda, Ángela Alonso, María Isabel Ruiz, Pedro Jesús Domínguez, Marcos Delgado, Eugenio Palazón, Antonio García-Jiménez, Rosa Álvaro, Clara Laplaza Eva Regidor, Enrique Maraví, José María Quiroga, Amalia Martínez de la Gandara, Cecilia Carbayo, María Luisa Navarrete, Manuel Valledor, Raquel Yano, José María Gutiérrez, Javier González-Robledo, Amparo Ferrandiz, Alberto Belenguer, Lidón Mateu, Laura Sayagues, María José Tolón, Nieves Franco, Elena Gallego, Félix Lacoma, Patricia Albert, Vicente Arraez, Mar Gobernado, Susana Moradillo, Carolina Gímenez-Esparza, Teresa Sánchez de Dios, Carlos Marian Crespo, Cecilia Hermosa, Federico Gordo, Genis Carrasco, María Ángeles Alonso, Alejandro Algora, Raúl de Pablo, Sofía García, Ana Carolina Caballero, José María Montón, Teresa Mut, Eva Manteiga, Alejandro de la Serna, Ana Esther Trujillo, Rafael Blancas, Inmaculada Vallverdú, José Manuel Serrano, Miquel Ferrer, Juan Diego Jiménez, Carlos Gallego, Dolores Vila, Luis Marina, Valentín Parra, Juan Ramón Cortés, Chen Chin-Ming, Ai-Chin Cheng, Fekri Abroug, Besbes Mohamed, Imed Chouchene, Mounir Bouaziz, Stambouli Neji, Islem Ouanes, Ayed Samia, Nahit Cakar, Ismail Kati, Ali Aydım Altunkan, Remzi Iscimen, Zafer Dogan, Bilge Çetin, Tayfun Adanir, Sabriye Guvenc, Unase Büyükkoçak, Antonio Anzueto, Ashley Ellis, Gary Kinasewitz, Allan Walkey, Phil Alkana, Gregory A Schmidt, Susan Gillen, Kathleen Lilli, Jennifer Twombley, Denice Wells, Larry Welder, Alejandro Arroliga, Alfredo Vasquez-Sandoval, Vincent John Scott, Craig Cernosek, Christopher Spradley, Dimple Tejwani, Sindhaghatta Venkatram, Gilda Diaz-Fuentes, Amber Monson, Anthony Saleh, Madhav Gudi, George Liziamma, Mohamed A Saad, Crissie De Spirito, Bryan Beatty, Samir Vermani, Crissie Despirito, Zaza Cohen, Amee Patrawalla, Samir Abdelhadi, Rupesh Vakil, Steven Y Chang, Brian Sherman, Rosanna Del Giudice, John Oropell, Timothy D Girard, Cayce Strength, Joyce Okahashi, Leanne Boehm, Matthew Kirchner, Ashley Ellis, Gary Kinasewitz, Erwin J Oei, Sebastian Circo, Nelson Medina, Mohammed Al-Jagbeer, V J Cardenas Jr, Smyth Smith, Shelby Sutton, Marcela Canola-Mazo, Tim Houlihan, Yogeet Kaur, Travis Parry, Craig A Piquette, Kerry Canady, Rahul Nanchal, Dana K Soetaert, Maria Del Mar Torres-Perez, Carlos Robles-Arias, William Rodriguez-Cintron, Mark Tidswell, Jennifer Germain, Lori-Ann Kozikowski, Erin Braden, Geneva Tatem, Javier Hurtado, Alberto Deicas, Daniel Weiss, Marta Beron, Román Garrido, Cristina Santos, Mario Cancela, Raúl Lombardi, Pedro Alzugaray, Jorge Gerez, Silvia Mareque, Graciela Franca, Oscar Cluzet, Edgardo Nuñez, Julio Pontet, Sergio Cáceres, Elias Caragna, Alberto Soler, Frank Torres, Gastón Pittini, Gabriel D Empaire, Stevens Salva, Fernando Pérez, Clara Pacheco, Zoraida Parra, Ingrid Von der Osten, Luis Williams, José Salinas, Do Danh Quynh, Pham Thi Van Anh, Nguyen Huu Hoang, Nghuyen Ba Tuan

Subjects
Male, medicine.medical_treatment, pulmonary complications, RESPIRATORY-DISTRESS-SYNDROME, Critical Care and Intensive Care Medicine, CASE-FATALITY, 0302 clinical medicine, Risk Factors, Brain Injuries, Traumatic, Multicenter Studies as Topic, Hospital Mortality, Prospective Studies, Simplified Acute Physiology Score, Stroke, POPULATION, Age Factors, ANEURYSMAL SUBARACHNOID HEMORRHAGE, Middle Aged, Hemorrhagic Stroke, Intensive Care Units, Observational Studies as Topic, Anesthesia, Breathing, Female, medicine.symptom, Ventilator Weaning, Cohort study, Adult, TRAUMATIC BRAIN-INJURY, Pressure support ventilation, mechanical ventilation, prognosis factors, ACUTE LUNG INJURY, 03 medical and health sciences, medicine, Humans, Aged, Ischemic Stroke, Mechanical ventilation, Noninvasive Ventilation, business.industry, MORTALITY, neurologic patients, Organ dysfunction, 030208 emergency & critical care medicine, Length of Stay, medicine.disease, TRENDS, Respiration, Artificial, 030228 respiratory system, Etiology, NEUROCRITICAL CARE, Nervous System Diseases, Tracheotomy, business
Abstract

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease.

Published
2021
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36. ICU-Acquired Pneumonia is a Risk Factor of a Poor Health Post-Covid-19 Syndrome

Author

José Luis García Garmendia, David de Gonzalo-Calvo, Laia Fernández-Barat, Elena Gallego, Pilar Ricart, Jesus F. Bermejo-Martin, Dario Garcia-Gasulla, Juan Lopez Messa, Ana Loza-Vázquez, Ignacio Martínez Varela, Cristina Carbajales, Víctor D. Gumucio Sanguino, Rosario Amaya Villar, José Barberán, Guillermo M. Albaiceta, Carme Barberà, Lorenzo Socias, Luis Urrelo-Cerrón, Emili Diaz, Raquel Pérez, Yhivian Peñasco, Anna Motos, Amalia Martínez de la Gándara, Ruth Noemí Jorge García, Aaron Blandino Ortiz, José A. Lorente, Jesús Caballero, Ignacio Martin-Loeches, Jordi Riera, Jessica González, Antoni Torres, Elena Bustamante-Munguira, Mariana Andrea Novo, Rosario Menéndez, Alejandro Rodriguez, Judith Marin-Corral, Adrian Ceccato, Luis Tamayo Lomas, Pablo Vidal, Oscar Peñuelas, Ricard Ferrer, Angel Sánchez-Miralles, Maria del Carmen de la Torre, Cristóbal Galbán, Nieves Carbonell, Ferran Barbé, Albert Gabarrus, Susana Sancho Chinesta, Mercedes Catalán-González, Jordi Solé-Violán, José Manuel Gómez, José Garnacho-Montero, and Luciano Aguilera

Subjects
Pneumonia, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medicine, Risk factor, business, medicine.disease, Intensive care medicine
Abstract

Background. Some patients who had previously presented with COVID-19 have been reported to develop persistent COVID-19 symptoms. Whilst this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the prevalence and risk factors and characteristics of persistent COVID_19 . On other hand these patients have very often intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence in the poor health post-Covid 19 syndrome in ICU discharged patientsMethods: This prospective, multicentre and observational study was done across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1,255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP) Patients requiring invasive mechanical ventilation had persistent, post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, and development of ICUAP were independent risk factors for persistent poor health post-COVID-19.Conclusions: Persistent, post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay and the onset of ICUAP comprised all independent risk factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-Covid 19

Published
2021
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37. Potential translation of plasma microRNA signatures in the risk stratification of COVID-19 patients admitted to the ICU

Author

Noelia Jorge, Silvia Pico, Amalia Martínez, Raquel Almansa, Rosario Menéndez, Lucía Pinilla, Amara Carratalá, Clara Gort-Paniello, Adrian Ceccato, Alicia Ortega, Anna Moncusí-Moix, Dario Garcia-Gasulla, Jordi Riera, Ferran Barbé, Gerard Torres, Jessica Gonzalez, Pablo Ryan, David de Gonzalo Calvo, Dariela Micheloud, José Manuel Gómez, Iván Benítez, Ana Motos, Oscar Peñuelas, Ricard Ferrer, Cesar Aldecoa, María Bernal, Milagros González-Rivera, Elena Bustamante-Munguira, Laia Fernandez, Jesus F. Bermejo-Martin, Antoni Torres, Marta Molinero, and Luis Tamayo

Subjects
Oncology, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Internal medicine, Risk stratification, microRNA, Medicine, Translation (biology), business
Published
2021
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39. Dynamic Mach–Zehnder interferometer based on a Michelson configuration and a cube beam splitter system

Author

J. M. Islas-Islas, Geliztle A. Parra-Escamilla, Gustavo Rodriguez-Zurita, L. García Lechuga, J. G. Ortega-Mendoza, David I. Serrano-García, V. H. Flores-Muñoz, Noel-Ivan Toto-Arellano, Amalia Martínez-García, and A. Montes Pérez

Subjects
Quantum optics, Physics, business.industry, Replica, Phase (waves), Physics::Optics, 02 engineering and technology, Polarizer, Mach–Zehnder interferometer, Interference (wave propagation), 01 natural sciences, Atomic and Molecular Physics, and Optics, law.invention, 010309 optics, Interferometry, 020210 optoelectronics & photonics, Optics, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, business, Beam splitter
Abstract

We developed simultaneous phase-shifting system based on a Mach–Zehnder interferometer and a replicating system integrated by a Michelson configuration and a cube beam splitter. The system is capable to obtain four simultaneous interferograms in a single capture, and the phase shifts are controlled by placing a linear polarizer in each replica obtained. The system retrieves four interferograms with a relative phase shift of π/2 and the optical phase map is calculated using the four-step algorithm. In addition, the configuration presents potential capabilities for generating spiral interference patterns. To show the advantage of the technique, experimental results are presented for static and dynamic samples.

Published
2019
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41. Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

Author

Jesús Troya, Aurora Pujol, Laurent Abel, Montse Ruiz, Amalia Martínez, Pablo Ryan, Juan Torres, Paul Bastard, Jean-Laurent Casanova, María de Carranza, and Laura Planas-Serra

Subjects
Adult, Male, medicine.medical_specialty, Lymphocyte, Immunology, Interferó, Pneumònia, severity biomarkers, Asymptomatic, Internal medicine, Immunology and Allergy, Medicine, Humans, Survival analysis, Aged, Autoantibodies, Aged, 80 and over, biology, business.industry, SARS-CoV-2, subcutaneous interferon-beta 1b, C-reactive protein, Autoantibody, COVID-19, Pneumonia, Middle Aged, medicine.disease, Comorbidity, Antibodies, Neutralizing, Hospitalization, medicine.anatomical_structure, C-Reactive Protein, type I IFN neutralizing autoantibodies, Cohort, Interferon Type I, biology.protein, Interferon, Original Article, Female, medicine.symptom, business
Abstract

Background In a recent study, autoantibodies neutralizing type I interferons (IFNs) were present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies neutralized most type I IFNs but rarely IFN-beta. Objectives We aimed to define the prevalence of autoantibodies neutralizing type I IFN in a cohort of patients with severe COVID-19 pneumonia treated with IFN-beta-1b during hospitalization and to analyze their impact on various clinical variables and outcomes. Methods We analyzed stored serum/plasma samples and clinical data of COVID-19 patients treated subcutaneously with IFN-beta-1b from March to May 2020, at the Infanta Leonor University Hospital in Madrid, Spain. Results The cohort comprised 47 COVID-19 patients with severe pneumonia, 16 of whom (34%) had a critical progression requiring ICU admission. The median age was 71 years, with 28 men (58.6%). Type I IFN-alpha- and omega-neutralizing autoantibodies were found in 5 of 47 patients with severe pneumonia or critical disease (10.6%), while they were not found in any of the 118 asymptomatic controls (p = 0.0016). The autoantibodies did not neutralize IFN-beta. No demographic, comorbidity, or clinical differences were seen between individuals with or without autoantibodies. We found a significant correlation between the presence of neutralizing autoantibodies and higher C-reactive protein levels (p = 5.10e−03) and lower lymphocyte counts (p = 1.80e−02). No significant association with response to IFN-beta-1b therapy (p = 0.34) was found. Survival analysis suggested that neutralizing autoantibodies may increase the risk of death (4/5, 80% vs 12/42, 28.5%). Conclusion Autoantibodies neutralizing type I IFN underlie severe/critical COVID-19 stages in at least 10% of cases, correlate with increased C-RP and lower lymphocyte counts, and confer a trend towards increased risk of death. Subcutaneous IFN-beta treatment of hospitalized patients did not seem to improve clinical outcome. Studies of earlier, ambulatory IFN-beta treatment are warranted. Supplementary Information The online version contains supplementary material available at 10.1007/s10875-021-01036-0.

Published
2021

42. ICU-Acquired Pneumonia is a Risk Factor of a Poor Health Post-Covid-19 Syndrome

Author

Martin-Loeches, Ignacio, primary, Motos, Anna, additional, Menéndez, Rosario, additional, Gabarrus, Albert, additional, González, Jessica, additional, Fernández-Barat, Laia, additional, Ceccato, Adrián, additional, Pérez, Raquel, additional, García-Gasulla, Dario, additional, Ferrer, Ricard, additional, Riera, Jordi, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Bermejo-Martin, Jesús F, additional, de Gonzalo-Calvo, David, additional, Rodríguez, Alejandro, additional, Barbé, Ferran, additional, Aguilera, Luciano, additional, Villar, Rosario Amaya, additional, Barberà, Carme, additional, Barberán, José, additional, Ortiz, Aaron Blandino, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Sanguino, Víctor D. Gumucio, additional, Torre, Maria del Carmen de la, additional, Díaz, Emili, additional, Gallego, Elena, additional, Garmendia, José Luis García, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, García, Ruth Noemí Jorge, additional, Loza-Vázquez, Ana, additional, Marin-Corral, Judith, additional, Gándara, Amalia Martínez de la, additional, Varela, Ignacio Martínez, additional, Messa, Juan Lopez, additional, Albaiceta, Guillermo M, additional, Novo, Mariana Andrea, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Urrelo-Cerrón, Luis, additional, Sánchez-Miralles, Angel, additional, Chinesta, Susana Sancho, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Lomas, Luis Tamayo, additional, Vidal, Pablo, additional, and Torres, Antoni, additional

Published
2021
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43. Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19

Author

González, Jessica, primary, Benítez, Iván D., additional, Carmona, Paola, additional, Santisteve, Sally, additional, Monge, Aida, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Pinilla, Lucía, additional, Carratalá, Amara, additional, Zuil, María, additional, Ferrer, Ricard, additional, Ceccato, Adrián, additional, Fernández, Laia, additional, Motos, Ana, additional, Riera, Jordi, additional, Menéndez, Rosario, additional, Garcia-Gasulla, Dario, additional, Peñuelas, Oscar, additional, Bermejo-Martin, Jesús F., additional, Labarca, Gonzalo, additional, Caballero, Jesus, additional, Torres, Gerard, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Villar, Rosario Amaya, additional, Añón, José M., additional, Barberà, Carme, additional, Barberán, José, additional, Ortiz, Aaron Blandino, additional, Bustamante-Munguira, Elena, additional, Caballero, Jesús, additional, Carbajales, Cristina, additional, Carbonell, Nieves, additional, Catalán-González, Mercedes, additional, Galbán, Cristóbal, additional, Gumucio, Victor Daniel, additional, de la Torre, Maria del Carmen, additional, Díaz, Emili, additional, Estella, Ángel, additional, Gallego, Elena, additional, García Garmendia, José Luis, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Huerta, Arturo, additional, Jorge García, Ruth Noemí, additional, Loza-Vázquez, Ana, additional, Marin-Corral, Judith, additional, de la Gándara, Amalia Martínez, additional, Varela, Ignacio Martínez, additional, Messa, Juan Lopez, additional, Albaiceta, Guillermo M., additional, Novo, Mariana Andrea, additional, Peñasco, Yhivian, additional, Pozo-Laderas, Juan Carlos, additional, Martí, Pilar Ricart, additional, Roche-Campo, Ferran, additional, Sánchez-Miralles, Angel, additional, Chinesta, Susana Sancho, additional, Socias, Lorenzo, additional, Solé-Violan, Jordi, additional, Sipmann, Fernando Suares, additional, Lomas, Luis Tamayo, additional, and Trenado, José, additional

Published
2021
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44. Neutralizing autoantibodies to type I IFNs in >10% of patients with severe COVID-19 pneumonia hospitalized in Madrid, Spain

Author

Jesús Troya García, Paul Bastard, Laura Planas-Serra, Pablo Ryan, Montse Ruíz, María de Carranza, Juan Torres, Amalia Martínez, Laurent Abel, Jean-Laurent Casanova, and Aurora Pujol

Abstract

Background: In a recent study, autoantibodies neutralizing type I interferons (IFNs) were present in at least 10% of cases of critical COVID-19 pneumonia. These autoantibodies neutralized most type I IFNs but rarely IFN-beta.Objectives: We aimed to define the prevalence of autoantibodies neutralizing type I IFN in a cohort of patients with severe COVID-19 pneumonia treated with IFN-beta-1b during hospitalization and to analyze their impact on various clinical variables and outcomes.Methods: We analyzed stored serum/plasma samples and clinical data of COVID-19 patients treated subcutaneously with IFN-beta-1b from March to May 2020, at the Infanta Leonor University Hospital in Madrid, Spain. Results: The cohort comprised 47 COVID-19 patients with severe pneumonia, 16 of whom (34%) had a critical progression requiring ICU admission. The median age was 71 years, with 28 men (58.6%). Type I IFN-alpha- and omega-neutralizing autoantibodies were found in 5 of 47 patients with severe pneumonia or critical disease (10.6%). The autoantibodies did not neutralize IFN-beta. No demographic, comorbidity, or clinical differences were seen between individuals with or without autoantibodies. We found a significant correlation between the presence of neutralizing autoantibodies and higher C-reactive protein levels (p=5.10e-03) and lower lymphocyte counts (p=1.80e-02). Survival analysis suggested that neutralizing autoantibodies may increase the risk of death (4/5, 80% vs 12/42, 28.5%).Conclusion: Autoantibodies neutralizing type I IFN underlie severe/critical COVID-19 stages in at least 10% of cases, correlate with increased C-RP and lower lymphocyte counts, and confer a trend towards increased risk of death. Subcutaneous IFN-beta treatment of hospitalized patients did not seem to improve clinical outcome. Studies of earlier, ambulatory IFN-beta treatment are warranted.

Published
2021
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45. 3D shape and strain measurement of a thin-walled elastic cylinder using fringe projection profilometry

Author

Juan Benito Pascual-Francisco, Amalia Martínez-García, Antonio de Jesús Ortiz-González, Juan Antonio Rayas-Álvarez, and Alexis de Jesús Flores-García

Subjects
Materials science, business.industry, Plane (geometry), System of measurement, Hydrostatic pressure, 01 natural sciences, Atomic and Molecular Physics, and Optics, Structured-light 3D scanner, law.invention, 010309 optics, Optics, Projector, law, 0103 physical sciences, Cylinder, Profilometer, Electrical and Electronic Engineering, Deformation (engineering), business, Engineering (miscellaneous)
Abstract

This paper describes an optical measurement system that is capable of simultaneously measuring a three-dimensional shape and circumferential train in a thin-walled cylinder. We used the fringe projection technique to obtain a three-dimensional shape and out-of-plane displacements, which were then associated with out-of-plane strain. Although 360 deg profilometry is not new, we propose an experimental setup that requires only one camera and one projector, since two mirrors are located at 120 deg with respect to the y − z plane of the reference system to obtain three distinct, complementary views of the sample studied. A sequence of images of the fringe pattern was captured and processed using the phase-shifting method, while the out-of-plane data were determined by comparing the specimen before and after deformation. A latex tube filled with liquid was used to perform mechanical testing. The cylinder was subjected to internal hydrostatic pressure that caused deformation. Experimental results were compared with analytical solutions, and the results show that out-of-plane strains can be accurately measured using the proposed method.

Published
2021

46. Non-axial osteoarticular tuberculosis in the paediatric age

Author

César Galo Fontecha, David Moreno-Romo, Antoni Noguera-Julian, Ferran Torner-Rubies, Teresa Subirá-Álvarez, Laura Montserrat Pérez-López, and Amalia Martínez-Ruíz

Subjects
Orthopedic surgery, 030203 arthritis & rheumatology, 0301 basic medicine, Surgical Procedures, Pediatria, Artritis, Tuberculosi, Arthritis, 030106 microbiology, Osteomyelitis, Mycobacterium tuberculosis, Pediatrics, Operative, 03 medical and health sciences, 0302 clinical medicine, Tuberculosis, Orthopedics and Sports Medicine, Surgery, RD701-811
Abstract

Resumen: Introducción y objetivos: La tuberculosis (TBC) osteoarticular, causada por una bacteria del género Mycobacterium, representa alrededor de un 10% del total de TBC extrapulmonares en la edad pediátrica. Su baja prevalencia y su presentación clínica inespecífica conducen a un diagnóstico tardío y, con esto, a un mayor riesgo de secuelas. Pacientes y método: Presentamos una serie de siete casos pediátricos de TBC osteoarticular no vertebral diagnosticados entre el 2006 y el 2019, con una media de edad de 7,4 años y una mediana de cinco (rango de dos a 16 años).El tiempo medio de seguimiento fue de 18,5 meses (rango 10 a 32 meses).Los pacientes se clasificaron según los criterios radiográficos de Kerri y Martini. Resultados: El retraso diagnóstico fue constante, con una media de 4,7 meses (rango de uno a ocho meses).La localización fue: cabeza femoral (dos casos), húmero proximal, cúpula astragalina, osteoartritis de clavícula distal, epífisis proximal de cúbito, y articulaciones tibioastragalina junto con subastragalina. Los hallazgos clínicos fueron cojera (cuatro casos), dolor localizado (dos), impotencia funcional (dos), síndrome constitucional (astenia, anorexia y pérdida involuntaria de más del 5% del peso corporal total) (dos), signos inflamatorios locales (uno), y fiebre (uno). Un paciente fue asintomático, realizando el diagnóstico osteoarticular de manera casual en el estudio radiológico pulmonar.Se administró un tratamiento médico de inducción con tres o cuatro fármacos en todos los casos. En tres de ellos, fue necesario el desbridamiento quirúrgico, y, en dos se realizó un lavado vía artroscópica. Conclusiones: Los resultados finales fueron aceptables, con recuperación del balance articular en el 71% de los pacientes, pero con cambios radiográficos residuales en cuatro de los siete casos (57,1%). El mejor pronóstico parece correlacionarse con la menor edad, así como con el diagnóstico y el tratamiento médico-quirúrgico precoces. Abstract: Introduction and objectives: Osteoarticular tuberculosis, caused by a member of the Mycobacterium genus, represents approximately 10% of the total extrapulmonary tuberculosis in pediatric patients. Its low prevalence and nonspecific clinical presentation lead to a late diagnosis and elevated risk of sequelae. Patients and methods: This retrospective study included seven pediatric patients with non-vertebral osteoarticular tuberculosis diagnosed between 2006 and 2019. The patients were classified in accordance with the radiographic criteria of Kerri and Martini. Results: The mean patient age was 7,4 years (median, 5 years; range, 2–16 years). The mean follow-up time was 18,5 months (range, 10–32 months). The mean diagnostic delay was 4,7 months (range, 1-8 months). The locations were femoral head osteoarthritis (two patients) and proximal humerus osteomyelitis, talus dome osteoarthritis, distal clavicle osteoarthritis, proximal ulna epiphysis osteoarthritis, and tibiotalar arthritis along with subtalar gland (one patient each). The clinical findings were lameness (four patients), localized pain (two patients), functional impotence, constitutional syndrome (asthenia, anorexia, and involuntary loss of>5% of total body weight) (two patients), local inflammatory signs (one patient), and fever (one patient). One patient was asymptomatic and received a diagnosis during pulmonary radiological analysis. Medical treatment with four drugs was performed in all patients; five patients required surgical treatment for abscess drainage, three of them open drainage, and two with laparoscopic drainage. Conclusions: The final results were satisfactory, such that 71% of patients recovered joint balance but with radiological sequelae in 57,1% patients. Good prognosis, according to our results, depends on younger age and early diagnosis with early medical or surgical treatments.

Published
2021

47. Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

Author

Iván Benítez, Jessica González, Marta Molinero, Elena Bustamante-Munguira, Cesar Aldecoa, Anna Motos, José Manuel Gómez, Luis Tamayo, Rosario Menéndez, Amara Carratalá, Antoni Torres, Laia Fernández-Barat, Dario Garcia-Gasulla, María Bernal, Jesus F. Bermejo-Martin, Lucía Pinilla, Amalia Martínez, Clara Gort-Paniello, Milagros González-Rivera, Anna Moncusí-Moix, Raquel Almansa, Adrian Ceccato, Silvia Pico, Gerard Torres, Dariela Micheloud, Jordi Riera, Oscar Peñuelas, Ricard Ferrer, Alicia Ortega, Ferran Barbé, David de Gonzalo-Calvo, Pablo Ryan, Noelia Jorge, and Barcelona Supercomputing Center

Subjects
Male, 0301 basic medicine, Hospitalized patients, Disease, Severity of Illness Index, COVID-19 (Malaltia), DISEASE, law.invention, 0302 clinical medicine, COVID-19 (Disease), law, microRNA, PLASMA, SIGNATURE, MicroRNA, General Medicine, MIRNA EXPRESSION, Intensive care unit, Hospitalization, Intensive Care Units, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Biomarkers in disease, Critical Illness, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Intensive Care Unit, Article, noncoding RNA, 03 medical and health sciences, Physiology (medical), Internal medicine, medicine, Humans, QUALITY, Circulating MicroRNA, Aged, SARS-CoV-2, business.industry, Biochemistry (medical), Public Health, Environmental and Occupational Health, COVID-19, Biomarker, 030104 developmental biology, RNA, Observational study, MicroRNA (miRNA), business, Biomarkers
Abstract

We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19 patients and evaluate its potential as a source of biomarkers for the management of the disease. This was an observational and multicenter study that included 84 patients with a positive nasopharyngeal swab Polymerase chain reaction (PCR) test for SARS-CoV-2 recruited during the first pandemic wave in Spain (March-June 2020). Patients were stratified according to disease severity: hospitalized patients admitted to the clinical wards without requiring critical care and patients admitted to the intensive care unit (ICU). An additional study was completed including ICU nonsurvivors and survivors. Plasma miRNA profiling was performed using reverse transcription polymerase quantitative chain reaction (RT-qPCR). Predictive models were constructed using least absolute shrinkage and selection operator (LASSO) regression. Ten circulating miRNAs were dysregulated in ICU patients compared to ward patients. LASSO analysis identified a signature of three miRNAs (miR-148a-3p, miR-451a and miR-486-5p) that distinguishes between ICU and ward patients [AUC (95% CI) = 0.89 (0.81-0.97)]. Among critically ill patients, six miRNAs were downregulated between nonsurvivors and survivors. A signature based on two miRNAs (miR-192-5p and miR-323a-3p) differentiated ICU nonsurvivors from survivors [AUC (95% CI) = 0.80 (0.64–0.96)]. The discriminatory potential of the signature was higher than that observed for laboratory parameters such as leukocyte counts, C-reactive protein (CRP) or D-dimer [maximum AUC (95% CI) for these variables = 0.73 (0.55–0.92)]. miRNA levels were correlated with the duration of ICU stay. Specific circulating miRNA profiles are associated with the severity of COVID-19. Plasma miRNA signatures emerge as a novel tool to assist in the early prediction of vital status deterioration among ICU patients. Supported by ISCIII (CIBERESUCICOVID, COV20/00110), co-funded by ERDF, “Una manera de hacer Europa”. DdGC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII), Miguel Servet 2020 (CP20/00041), co-funded by the European Social Fund (ESF), “Investing in your future”. LP is the recipient of a predoctoral fellowship from the Ministry of Universities of Spain (FPU19/03526). This work partially supported by IRBLleida Biobank (B.0000682) and “Plataforma Biobancos PT17/0015/0027/”. Peer Reviewed "Article signat per 33 autors/es: David de Gonzalo-Calvo, Iván D. Benítez, Lucía Pinilla, Amara Carratalá, Anna Moncusí-Moix, Clara Gort-Paniello, Marta Molinero, Jessica González, Gerard Torres, María Bernal, Silvia Pico, Raquel Almansa, Noelia Jorge, Alicia Ortega, Elena Bustamante-Munguira, José Manuel Gómez, Milagros González-Rivera, Dariela Micheloud, Pablo Ryan, Amalia Martinez, Luis Tamayo, César Aldecoa, Ricard Ferrer, Adrián Ceccato, Laia Fernández-Barat, Ana Motos, Jordi Riera, Rosario Menéndez, Dario Garcia-Gasulla, Oscar Peñuelas, Antoni Torres, Jesús F. Bermejo-Martin, Ferran Barbé on behalf of the Ciberesucicovid Project (Cov20/00110, Isciii)"

Published
2021

48. Aplicación del Modelo de Adaptación de Roy: Proceso de Enfermería a una Persona con Pie Diabético

Author

Valentina Rivas Acuña, Yadira Mateo Crisóstomo, Amalia Martínez Serrano, Marina del Carmen Osorio Aquino, Griselda Hernández Ramírez, and Nallely García Hernández

Subjects
Philosophy, Persona, Model nursing, Humanities
Abstract

El Proceso de Atención de Enfermería, es un método propio de la praxis de enfermería y conforme pasa el tiempo va adquiriendo mayor relevancia para la ejecución de un buen cuidado. El objetivo de este caso clínico fue desarrollar un plan de cuidados según el Modelo de Adaptación de Roy en un paciente con pie diabético. En este trabajo metodológico, se abordan las etapas del proceso propuesto por el Modelo de Adaptación. La valoración de enfermería utiliza herramientas para la recolección de datos como: entrevista, observación y exploración física y su uso contribuye a la identificación del modo adaptativo afectado, en este caso, el Modo Fisiológico. Se citaron las taxonomías de los diagnósticos de enfermería (NANDA) para la identificación y redacción de diagnósticos enfermeros; además del uso de la clasificación de las intervenciones de enfermería (NIC) y clasificación de los resultados de enfermería (NOC) para las intervenciones y resultados esperados. Como resultados relevantes se obtuvieron que, en los Proceso Complejos, en el equilibrio de líquidos, electrolitos y ácido-base se observó una mejoría de 8 a 18 puntos, al realizar el control estricto de líquidos en 24 horas, obteniendo un balance negativo.La utilización del Modelo de Adaptación como marco de referencia para la aplicación del Proceso de Enfermería destaca la necesidad de evaluar a la persona como un sistema completo; ya que la valoración fisiológica y psicosocial constituye una oportunidad para conocer no solo el estado de salud, sino también la percepción la situación que está viviendo en este momento, cómo la está afrontando y cuáles son sus expectativas frente al cuidado de enfermería, para promover su adaptación.

Published
2020
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49. Dynamic parallel phase-shifting electronic speckle pattern interferometer

Author

Gustavo Rodriguez-Zurita, Amalia Martínez-García, Noel-Ivan Toto-Arellano, Yukitoshi Otani, Luis García-Lechuga, Juan A. Rayas, Gustavo A. Gómez-Méndez, and David I. Serrano-García

Subjects
Physics, Observational error, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, Phase (waves), Polarization (waves), Atomic and Molecular Physics, and Optics, Speckle pattern, Interferometry, Optics, Phase shifted, Electronic speckle pattern interferometry, Electrical and Electronic Engineering, business, Engineering (miscellaneous), Circular polarization
Abstract

Methods for measuring variations in diffuse surfaces using electronic speckle pattern interferometry (ESPI) are widely used and well known. In this research, we present an out-of-plane ESPI system coupled to a Michelson configuration to generate simultaneous parallel interferograms with different phase shifts. The system uses circular polarization states to generate parallel phase shifted interferograms. Due to the polarization states, the fringes do not experience a contrast reduction, thus avoiding measurement errors that affect spatial or temporal phase-shifting in interferometry. The basic operating principle of polarization modulation is described, and results that represent the temporal evolution of an aluminum plate are presented. The generation of two simultaneous patterns allows one to track the dynamic performance of the plate.

Published
2020

50. Phase stepping through polarizing modulation in electronic speckle pattern interferometry

Author

Amalia Martínez-García, Gustavo A. Gómez-Méndez, Yukitoshi Otani, Gustavo Rodriguez-Zurita, David I. Serrano-García, Noel-Ivan Toto-Arellano, and Luis García-Lechuga

Subjects
Physics, business.industry, Polarization modulation, Polarizer, Polarization (waves), 01 natural sciences, Atomic and Molecular Physics, and Optics, law.invention, 010309 optics, Speckle pattern, Interferometry, Optics, law, Electronic speckle pattern interferometry, 0103 physical sciences, Speckle imaging, Electrical and Electronic Engineering, business, Engineering (miscellaneous), Circular polarization
Abstract

We have demonstrated a speckle out-of-plane interferometer that employs phase-stepping procedures by means of polarization modulation. The system generates circular polarization states with opposite signs at each arm of the system, which overlap at the output of the interferometer, to generate phase shifts operating a conventional linear polarizer; the emerging polarization states have been analyzed to obtain the shifts needed to process the optical phase. The phase-stepping technique is demonstrated with a two-step algorithm to measure out-of-plane displacement on a flat metal plate.

Published
2020

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