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ஆய்வுச் சுருக்கம் நாளுக்கு நாள் மனிதர்களை அச்சத்திற்கு உள்ளாக்கும் விதமாக புதியப்புதிய நோய்க்கிருமிகள் அறிவியலின் துணையோடு மனிதனால் தோற்றுவிக்கப்படுகின்றன. இவற்றினால் மனிதன் பெருமிழப்பைச் சந்திப்பதுடன், அவற்றை அழிக்கவோ எதிர்க்கவோ முடியாமல் திணறுகின்றான். இவற்றிற்க்கு காரணம் மனிதரின் உடலமைப்பையும் தமிழரின் வாழ்க்கை நெறியையும் உணராத நிலையே ஆகும். இயற்கையோடு இணைந்தும் இயந்தும் வாழ்ந்த வாழ்க்கை முறையே நம் தமிழ் மரபு. நாம் எவ்வாறு இயற்கையோடு இயந்த வாழ்ந்தால் நோக்கிருமிகளிலிருந்து விலகி நலமுடன் வாழலாம் என்பதை, பகுப்புமுறை ஆய்வு, தொகுப்புமுறை ஆய்வு, விளக்கமுறை திறனாய்வு பின்பற்றப்பட்டு விளக்கப்படுகின்றது.

Five previously known anthraquinones with amino derivatives and synthesized new triazene (1-[(1E)-3,3-bis(2-hydroxyethyl)triaz-1-en-1-ol]-4-[(2-hydroxyethyl)amino]anthracene-9,10-dione) were evaluated in-silico as inhibitors of COVID-19 main protease. Preliminary screening has shown that the presence of a sulfo group in the second position of the anthraquinone ring reduces activity, probably due to the inability of the molecule to cross the hydrophilic-lipophilic barrier. Therefore, the desulfation reaction of 4-substituted anthraquinone was carried out and triazene was synthesized on its basis, which due to the presence of a triazene bridge showed good activity. The structures of the synthesized compound were confirmed by IR, 1H, 13C NMR, and LC-MS spectral studies. Chemo-informatics study showed that the compound obeyed the Lipinski's rule. Computational docking analysis was performed using PyRx, AutoDock Vina option based on scoring functions. In-silico molecular docking study results demonstrated Greater binding energy and affinity to the active pocket the N3 binding site of the Coronavirus primary protease., П’ять раніше відомих антрахінонів з амінопохідними та синтезований новий триазен (1-[(1E)-3,3-біс(2-гідроксиетил)триаз-1-eн-1-oл]-4-[(2-гідроксиетил)aміно]антрацен-9,10-діон) оцінювали in-silico як потенційних інгібіторів основної протеази COVID-19. Попередній скринінг виявив, що наявність сульфогрупи в другому положенні антрахінонового кільця зменшує активність ймовірно через нездатність молекули пройти через гідрофільно-ліпофільний бар’єр. Тому проведено реакцію десульфування 4-заміщеного антрахінону і на його основі синтезовано триазен, який завдяки наявності триазенового містка проявив хорошу активність. Структури синтезованої сполуки підтверджено ІЧ, 1H, 13C ЯМР та LC-MS спектральними дослідженнями. Хіміко-інформаційне дослідження показало, що сполука підкорялася правилу Ліпінського. Обчислювальний аналіз in-silico проводився з використанням PyRx, параметра AutoDock Vina на основі функцій оцінки. Результати дослідження молекулярного докінгу продемонстрували більшу енергію зв’язування та спорідненість з активним ділянкою зв’язування N3 первинної протеази коронавірусу.

Early detection and diagnosis of faulty events in industrial processes can represent economic, social and environmental profits. When the process has a great quantity of sensors or actuators, the Fault Detection and Isolation (FDI) task is very difficult. Advanced statistical based FDI methods are extensively used for fault detection and isolation purposes. In this work, three multivariate statistical techniques such as neural network based Principal Component Analysis (PCA), neural network-based Fischer Discriminant Analysis (FDA) and Correspondence Analysis (CA) was applied to the multivariate data extracted from laboratory scale shell and tube heat exchanger. Performance metric such as detection delay, estimated time of occurrence of fault, misclassification rate was computed for those three techniques for the detection and isolation of biases in sensors and actuators. Correspondence Analysis was proven to perform better when compared to PCA and FDA. CA was observed to perform FDI with minimal detection delay (which is less than or equal to 7 seconds) and lower misclassification rate (which is less than or equal to 6%) in case of both sensor & actuator faults. PCA and FDA showed significant detection delay and missed alarm rate for single and multiple fault identification.

Objective: We aim to review existing literature on the effects of background music in waiting rooms on patients. Furthermore, we examine existing neurobiological research for potential mechanisms by which music may affect patients. Background: Music has been studied in healthcare in various forms, from formal interventions such as music therapy to passive listening as therapy. However, music is also present in the healthcare environment in the form of background music in waiting rooms. There has been interest in whether background music in such a setting may have beneficial effects on patient anxiety in order to potentially inform healthcare workers whether and what type of music may be suitable for waiting rooms. Methods: We reviewed existing literature on music in healthcare waiting rooms and the neurobiological mechanisms by which music affects anxiety. Results: We located several small studies performed in a range of settings, including physician office waiting rooms and preoperative waiting areas. The studies generally reported that most patients viewed music in these areas positively; some, but not all, studies showed positive effects on patient anxiety. A variety of theories by which music may impact patient anxiety was noted. Conclusions: We conclude that there exists some evidence to support an anxiety-reducing effect of background music on patients, though studies vary widely in methodology and music selection. A small amount of neurobiological research into the pertinent mechanisms has been conducted, but further research will be required to elucidate the exact mechanisms by which this intervention may reduce anxiety.

Background: Plastic surgeons treat a large volume of patients with upper limb morbidity resulting from intravenous drug use. The use of motivational interviewing by health care providers has demonstrated effectiveness in eliciting behavioral change, leading to improved health outcomes. This paper aims to explore the concept and process of motivational interviewing and its role in facilitating behavior change in the plastic surgery setting. Methods: The authors reviewed the literature on motivational interviewing in various health care settings. Results: Motivational interviewing, first developed in the field of psychology, has demonstrated effectiveness in facilitating behavior change in various clinical contexts, including brief clinical encounters. Using motivational interviewing guides the patient as they move through the stages of readiness for change in dealing with unhealthy behaviors. The authors demonstrate these techniques in a supplemental instructional video. Conclusions: Motivational interviewing is an evidence-based method for facilitating behavior change. All plastic surgeons should be prepared to use this person-centred counselling method in clinical practice.

An exclusive approach towards the synthesis of novel 3‐(hydroxymethyl)‐2‐phenyl‐2,3 dihydroquinolin‐4(1H)‐one and it's in‐silico evaluation as inhibitor of COVID‐19 main protease. The one‐pot synthesis of an established procedure Claisen ester condensation reaction was sodium hydride mediated with intramolecular cyclization with solvent free conditions. The structures of the synthesized compound were confirmed by IR, 1H,13C NMR, and EI‐MS spectral studies. Chemo‐informatics study showed that the compound obeyed the Lipinski's rule, PASS, Swiss ADME. Computational docking analysis was performed using PyRx, AutoDock Vina option based on scoring functions. In‐silico molecular docking study results demonstrated Greater binding energy and affinity to the active pocket the N3 binding site of the Coronavirus primary protease.

Proclaiming the Good News of Jesus is the centrality of every Christian mission. This proclamation becomes dialogical through the integrating process of cosmic and metacosmic religions which facilitates the salvific divine-human encounter. The Church has come to realize this process only progressively. It is necessary to understand and to accept this process and this new vision, especially in the context of globalization, which has, increasingly, also a religious dimension. The Asian vision of mission seems relevant across the world as Hindu and Buddhist gurus make their ethical presence felt globally, particularly in Europe and North America. The ultimate goal of mission is the Kingdom of God and the Church as its symbol and servant. We recognize today that the Church is a co-pilgrim, together with other religions, who are fellow pilgrims towards this Kingdom. We are then called to dialogue and collaborate with people around the world. In this process, the Church is called to be in dialogue always with the poor, the cultures and the other religions.

This article presents the design of an advanced smart grid model with an improved optimal variation strategy by implementing renewable energy sources. The novelty involved in this article is design...

Eight new 4-substituted 1-amino-9,10-anthraquinones containing a primary amino group were syn­the­sized by nucleophilic substitution of bromine in 1-amino-4-bromo-9,10-anthraquinones. 1-Amino-4-[2-(hy­droxy­ethyl)amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid containing a biogenic amine fragment (2-aminoethanol) was converted into the corresponding 1-triazenyl derivatives. The structure of the synthesized compounds was determined on the basis of the LC/MS and 13C and 1H NMR data, and their drug likeness was estimated in silico. Compounds with a good drug likeness score were analyzed by DIGEP-Pred, their possible interactions with proteins were simulated using STRING, and their biological activity was interpreted using the Kyoto Encyclopedia of Genes and Genomes.