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1. Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients.

Author

Kyle Jablonski, Nicholas A Young, Caitlin Henry, Kyle Caution, Anuradha Kalyanasundaram, Ifeoma Okafor, Peter Harb, Emmy Schwarz, Paul Consiglio, Chris M Cirimotich, Anna Bratasz, Anasuya Sarkar, Amal O Amer, Wael N Jarjour, and Naomi Schlesinger

Subjects
Medicine, Science
Abstract

ObjectivesGout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical outcome, we examined inflammatory pathogenesis in an acute model of murine gout and analyzed human gout patient clinical data as a function of physical activity.MethodsNF-κB-luciferase reporter mice were organized into four groups and exercised at 0 m/min (non-exercise), 8 m/min (low-intensity), 11 m/min (moderate-intensity), and 15 m/min (high-intensity) for two weeks. Mice subsequently received intra-articular monosodium urate (MSU) crystal injections (0.5mg) and the inflammatory response was analyzed 15 hours later. Ankle swelling, NF-κB activity, histopathology, and tissue infiltration by macrophages and neutrophils were measured. Toll-like receptor (TLR)2 was quantified on peripheral monocytes/neutrophils by flow cytometry and both cytokines and chemokines were measured in serum or synovial aspirates. Clinical data and questionnaires accessing overall physical activity levels were collected from gout patients.ResultsInjection of MSU crystals produced a robust inflammatory response with increased ankle swelling, NF-κB activity, and synovial infiltration by macrophages and neutrophils. These effects were partially mitigated by low and moderate-intensity exercise. Furthermore, IL-1β was decreased at the site of MSU crystal injection, TLR2 expression on peripheral neutrophils was downregulated, and expression of CXCL1 in serum was suppressed with low and moderate-intensity exercise. Conversely, the high-intensity exercise group closely resembled the non-exercised control group by nearly all metrics of inflammation measured in this study. Physically active gout patients had significantly less flares/yr, decreased C-reactive protein (CRP) levels, and lower pain scores relative to physically inactive patients.ConclusionsRegular, moderate physical activity can produce a quantifiable anti-inflammatory effect capable of partially mitigating the pathologic response induced by intra-articular MSU crystals by downregulating TLR2 expression on circulating neutrophils and suppressing systemic CXCL1. Low and moderate-intensity exercise produces this anti-inflammatory effect to varying degrees, while high-intensity exercise provides no significant difference in inflammation compared to non-exercising controls. Consistent with the animal model, gout patients with higher levels of physical activity have more favorable prognostic data. Collectively, these data suggest the need for further research and may be the foundation to a future paradigm-shift in conventional exercise recommendations provided by Rheumatologists to gout patients.

Published
2020
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3. Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages.

Author

Chandra L Shrestha, Kaivon D Assani, Hannah Rinehardt, Florentina Albastroiu, Shuzhong Zhang, Richard Shell, Amal O Amer, Larry S Schlesinger, and Benjamin T Kopp

Subjects
Medicine, Science
Abstract

Members of the Burkholderia cepacia complex are virulent, multi-drug resistant pathogens that survive and replicate intracellularly in patients with cystic fibrosis (CF). We have discovered that B. cenocepacia cannot be cleared from CF macrophages due to defective autophagy, causing continued systemic inflammation and infection. Defective autophagy in CF is mediated through constitutive reactive oxygen species (ROS) activation of transglutaminase-2 (TG2), which causes the sequestration (accumulation) of essential autophagy initiating proteins. Cysteamine is a TG2 inhibitor and proteostasis regulator with the potential to restore autophagy. Therefore, we sought to examine the impact of cysteamine on CF macrophage autophagy and bacterial killing. Human peripheral blood monocyte-derived macrophages (MDMs) and alveolar macrophages were isolated from CF and non-CF donors. Macrophages were infected with clinical isolates of relevant CF pathogens. Cysteamine caused direct bacterial growth killing of live B. cenocepacia, B. multivorans, P. aeruginosa and MRSA in the absence of cells. Additionally, B. cenocepacia, B. multivorans, and P. aeruginosa invasion were significantly decreased in CF MDMs treated with cysteamine. Finally, cysteamine decreased TG2, p62, and beclin-1 accumulation in CF, leading to increased Burkholderia uptake into autophagosomes, increased macrophage CFTR expression, and decreased ROS and IL-1β production. Cysteamine has direct anti-bacterial growth killing and improves human CF macrophage autophagy resulting in increased macrophage-mediated bacterial clearance, decreased inflammation, and reduced constitutive ROS production. Thus, cysteamine may be an effective adjunct to antibiotic regimens in CF.

Published
2017
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4. Caspase exploitation by Legionella pneumophila

Author

Kathrin eKrause and Amal O Amer

Subjects
Caspases, Legionella pneumophila, NOD Like Receptors, Cell Death Mechanisms, Phagosomal maturation, Microbiology, QR1-502
Abstract

Legionella pneumophila remains a major health concern, especially for hospitalized patients. L. pneumophila in the environment can survive extracellular or as protozoan parasite within amoeba. After human infection it efficiently replicates in alveolar macrophages without activating inflammasome assembly and cleavage of caspase-1. In contrast murine macrophages actively recognize intracellular L. pneumophila via inflammasome components which initiate pro-inflammatory cytokine secretion, phagosomal maturation and pyroptotic cell death thereby leading to bacterial restriction. During this process flagellin-dependent and -independent signaling pathways trigger the canonical as well as the non-canonical inflammasome. This review describes the current knowledge about L. pneumophila-induced inflammasome pathways in permissive and restrictive host cells.

Published
2016
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5. The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.

Author

Arwa Abu Khweek, Apurva Kanneganti, Denis C Guttridge D, and Amal O Amer

Subjects
Medicine, Science
Abstract

L. pneumophila is the causative agent of Legionnaires' disease, a human illness characterized by severe pneumonia. In contrast to those derived from humans, macrophages derived from most mouse strains restrict L. pneumophila replication. The restriction of L. pneumophila replication has been shown to require bacterial flagellin, a component of the type IV secretion system as well as the cytosolic NOD-like receptor (NLR) Nlrc4/ Ipaf. These events lead to caspase-1 activation which, in turn, activates caspase-7. Following caspase-7 activation, the phagosome-containing L. pneumophila fuses with the lysosome, resulting in the restriction of L. pneumophila growth. The LegS2 effector is injected by the type IV secretion system and functions as a sphingosine 1-phosphate lyase. It is homologous to the eukaryotic sphingosine lyase (SPL), an enzyme required in the terminal steps of sphingolipid metabolism. Herein, we show that mice Bone Marrow-Derived Macrophages (BMDMs) and human Monocyte-Derived Macrophages (hMDMs) are more permissive to L. pneumophila legS2 mutants than wild-type (WT) strains. This permissiveness to L. pneumophila legS2 is neither attributed to abolished caspase-1, caspase-7 or caspase-3 activation, nor due to the impairment of phagosome-lysosome fusion. Instead, an infection with the legS2 mutant resulted in the reduction of some inflammatory cytokines and their corresponding mRNA; this effect is mediated by the inhibition of the nuclear transcription factor kappa-B (NF-κB). Moreover, BMDMs infected with L. pneumophila legS2 mutant showed elongated mitochondria that resembles mitochondrial fusion. Therefore, the absence of LegS2 effector is associated with reduced NF-κB activation and atypical morphology of mitochondria.

Published
2016
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6. Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Author

Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, and Jacob S. Yount

Subjects
Science
Abstract

Abstract Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (Gsdmd −/− ) significantly attenuates influenza virus-induced weight loss, lung dysfunction, lung histopathology, and mortality compared with wild type (WT) mice, despite similar viral loads. Infected Gsdmd −/− mice exhibit decreased inflammatory gene signatures shown by lung transcriptomics. Among these, diminished neutrophil gene activation signatures are corroborated by decreased detection of neutrophil elastase and myeloperoxidase in KO mouse lungs. Indeed, directly infected neutrophils are observed in vivo and infection of neutrophils in vitro induces release of DNA and tissue-damaging enzymes that is largely dependent on GSDMD. Neutrophil depletion in infected WT mice recapitulates the reductions in mortality, lung inflammation, and lung dysfunction observed in Gsdmd −/− animals, while depletion does not have additive protective effects in Gsdmd −/− mice. These findings implicate a function for GSDMD in promoting lung neutrophil responses that amplify influenza virus-induced inflammation and pathogenesis. Targeting the GSDMD/neutrophil axis may provide a therapeutic avenue for treating severe influenza.

Published
2024
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7. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Author

Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous, Owen Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, Abbey A. Saadey, Brooke Laster, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Olga N. Kokiko-Cochran, Hazem E. Ghoneim, and Amal O. Amer

Subjects
Alzheimer’s disease, Inflammasome, Inflammation, Caspase-4, Caspase-11, Methylation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Alzheimer’s disease (AD) is the sixth leading cause of death in the USA. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune phagocytes of the brain. For instance, microglia release pro-inflammatory products such as IL-1β which is highly implicated in AD pathobiology. The mechanisms underlying the transition of microglia to proinflammatory promoters of AD remain largely unknown. To address this gap, we performed reduced representation bisulfite sequencing (RRBS) to profile global DNA methylation changes in human AD brains compared to no disease controls. We identified differential DNA methylation of CASPASE-4 (CASP4), which when expressed promotes the generation of IL-1β and is predominantly expressed in immune cells. DNA upstream of the CASP4 transcription start site was hypomethylated in human AD brains, which was correlated with increased expression of CASP4. Furthermore, microglia from a mouse model of AD (5xFAD) express increased levels of CASP4 compared to wild-type (WT) mice. To study the role of CASP4 in AD, we developed a novel mouse model of AD lacking the mouse ortholog of CASP4 and CASP11, which is encoded by mouse Caspase-4 (5xFAD/Casp4 −/− ). The expression of CASP11 was associated with increased accumulation of pathologic protein aggregate amyloid-β (Aβ) and increased microglial production of IL-1β in 5xFAD mice. Utilizing RNA-sequencing, we determined that CASP11 promotes unique transcriptomic phenotypes in 5xFAD mouse brains, including alterations of neuroinflammatory and chemokine signaling pathways. Notably, in vitro, CASP11 promoted generation of IL-1β from macrophages in response to cytosolic Aβ through cleavage of downstream effector Gasdermin D (GSDMD). Therefore, here we unravel the role for CASP11 and GSDMD in the generation of IL-1β in response to Aβ and the progression of pathologic inflammation in AD. Overall, our results demonstrate that overexpression of CASP4 due to differential DNA methylation in AD microglia contributes to the progression of AD pathobiology. Thus, we identify CASP4 as a potential target for immunotherapies for the treatment and prevention of AD.

Published
2024
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9. IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages.

Author

Kaivon Assani, Mia F Tazi, Amal O Amer, and Benjamin T Kopp

Subjects
Medicine, Science
Abstract

Burkholderia cenocepacia is a virulent pathogen that causes significant morbidity and mortality in patients with cystic fibrosis (CF), survives intracellularly in macrophages, and uniquely causes systemic infections in CF. Autophagy is a physiologic process that involves engulfing non-functional organelles and proteins and delivering them for lysosomal degradation, but also plays a role in eliminating intracellular pathogens, including B. cenocepacia. Autophagy is defective in CF but can be stimulated in murine CF models leading to increased clearance of B. cenocepacia, but little is known about autophagy stimulation in human CF macrophages. IFN-γ activates macrophages and increases antigen presentation while also inducing autophagy in macrophages. We therefore, hypothesized that treatment with IFN-γ would increase autophagy and macrophage activation in patients with CF. Peripheral blood monocyte derived macrophages (MDMs) were obtained from CF and non-CF donors and subsequently infected with B. cenocepacia. Basal serum levels of IFN-γ were similar between CF and non-CF patients, however after B. cenocepacia infection there is deficient IFN-γ production in CF MDMs. IFN-γ treated CF MDMs demonstrate increased co-localization with the autophagy molecule p62, increased autophagosome formation, and increased trafficking to lysosomes compared to untreated CF MDMs. Electron microscopy confirmed IFN-γ promotes double membrane vacuole formation around bacteria in CF MDMs, while only single membrane vacuoles form in untreated CF cells. Bacterial burden is significantly reduced in autophagy stimulated CF MDMs, comparable to non-CF levels. IL-1β production is decreased in CF MDMs after IFN-γ treatment. Together, these results demonstrate that IFN-γ promotes autophagy-mediated clearance of B. cenocepacia in human CF macrophages.

Published
2014
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10. Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages

Author

Arwa eAbu Khweek, Natalia eFernández Dávila, Kyle eCaution, Anwari eAkhter, Basant eAbdulrahman, Mia eTazi, Hoda eHassan, Laura eNovotny, Lauren eBakaletz, and Amal O Amer

Subjects
Apoptosis, Flagellin, Legionella pneumophila, Lysosomes, innate immunity, Biofilm, Microbiology, QR1-502
Abstract

Legionella pneumophila, the causative agent of Legionnaire’s disease, replicates in human alveolar macrophages to establish infection. There is no human-to-human transmission and the main source of infection is L. pneumophila biofilms established in air conditioners, water fountains, and hospital equipments. The biofilm structure provides protection to the organism from disinfectants and antibacterial agents. L. pneumophila infection in humans is characterized by a subtle initial immune response, giving time for the organism to establish infection before the patient succumbs to pneumonia. Planktonic L. pneumophila elicits a strong immune response in murine, but not in human macrophages enabling control of the infection. Interactions between planktonic L. pneumophila and murine or human macrophages have been studied for years, yet the interface between biofilm-derived L. pneumophila and macrophages has not been explored. Here, we demonstrate that biofilm-derived L. pneumophila replicates significantly more in murine macrophages than planktonic bacteria. In contrast to planktonic L. pneumophila, biofilm-derived L. pneumophila lacks flagellin expression, do not activate caspase-1 or 7 and trigger less cell death. In addition, while planktonic L. pneumophila is promptly delivered to lysosomes for degradation, most biofilm-derived bacteria were enclosed in a vacuole that did not fuse with lysosomes in murine macrophages. This study advances our understanding of the innate immune response to biofilm-derived L. pneumophila and closely reproduces the natural mode of infection in human.

Published
2013
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11. Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein.

Author

Laura A Novotny, Amal O Amer, M Elizabeth Brockson, Steven D Goodman, and Lauren O Bakaletz

Subjects
Medicine, Science
Abstract

Cystic fibrosis (CF) is the most common lethal inherited genetic disorder affection Caucasians. Even with medical advances, CF is life-shortening with patients typically surviving only to age 38. Infection of the CF lung by Burkholderia cenocepacia presents exceptional challenges to medical management of these patients as clinically this microbe is resistant to virtually all antibiotics, is highly transmissible and infection of CF patients with this microbe renders them ineligible for lung transplant, often the last lifesaving option. Here we have targeted two abundant components of the B. cenocepacia biofilm for immune intervention: extracellular DNA and DNABII proteins, the latter of which are bacterial nucleic acid binding proteins. Treatment of B. cenocepacia biofilms with antiserum directed at one of these DNABII proteins (integration host factor or IHF) resulted in significant disruption of the biofilm. Moreover, when anti-IHF mediated destabilization of a B. cenocepacia biofilm was combined with exposure to traditional antibiotics, B. cenocepacia resident within the biofilm and thereby typically highly resistant to the action of antibiotics, were now rendered susceptible to killing. Pre-incubation of B. cenocepacia with anti-IHF serum prior to exposure to murine CF macrophages, which are normally unable to effectively degrade ingested B. cenocepacia, resulted in a statistically significant increase in killing of phagocytized B. cenocepacia. Collectively, these findings support further development of strategies that target DNABII proteins as a novel approach for treatment of CF patients, particularly those whose lungs are infected with B. cenocepacia.

Published
2013
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12. Burkholderia cenocepacia type VI secretion system mediates escape of type II secreted proteins into the cytoplasm of infected macrophages.

Author

Roberto Rosales-Reyes, Daniel F Aubert, Jennifer S Tolman, Amal O Amer, and Miguel A Valvano

Subjects
Medicine, Science
Abstract

Burkholderia cenocepacia is an opportunistic pathogen that survives intracellularly in macrophages and causes serious respiratory infections in patients with cystic fibrosis. We have previously shown that bacterial survival occurs in bacteria-containing membrane vacuoles (BcCVs) resembling arrested autophagosomes. Intracellular bacteria stimulate IL-1β secretion in a caspase-1-dependent manner and induce dramatic changes to the actin cytoskeleton and the assembly of the NADPH oxidase complex onto the BcCV membrane. A Type 6 secretion system (T6SS) is required for these phenotypes but surprisingly it is not required for the maturation arrest of the BcCV. Here, we show that macrophages infected with B. cenocepacia employ the NLRP3 inflammasome to induce IL-1β secretion and pyroptosis. Moreover, IL-1β secretion by B. cenocepacia-infected macrophages is suppressed in deletion mutants unable to produce functional Type VI, Type IV, and Type 2 secretion systems (SS). We provide evidence that the T6SS mediates the disruption of the BcCV membrane, which allows the escape of proteins secreted by the T2SS into the macrophage cytoplasm. This was demonstrated by the activity of fusion derivatives of the T2SS-secreted metalloproteases ZmpA and ZmpB with adenylcyclase. Supporting this notion, ZmpA and ZmpB are required for efficient IL-1β secretion in a T6SS dependent manner. ZmpA and ZmpB are also required for the maturation arrest of the BcCVs and bacterial intra-macrophage survival in a T6SS-independent fashion. Our results uncover a novel mechanism for inflammasome activation that involves cooperation between two bacterial secretory pathways, and an unanticipated role for T2SS-secreted proteins in intracellular bacterial survival.

Published
2012
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13. Asc-dependent and independent mechanisms contribute to restriction of Legionella pneumophila infection in murine macrophages

Author

Amal O Amer, Dalia H.A. Abdelaziz, Mikhail A Gavrilin, Anwari eAkhter, Kyle eCaution, Sheetal eKotrange, Arwa eAbu Khweek, Basant A. Abdulrahman, Zeinab A. Hassan, Fathia Z. El-Sharkawi, Simranjit S. Bedi, Katherine eLadner, Mahmoud eMostafa, Andrea eDoseff, Elba M Gonzalez-Mejia, Dennis eGuttridge, Thirumala-Devi eKanneganti, Clay B. Marsh, and Mark D. Wewers

Subjects
Legionella pneumophila, Inflammasome, caspase-1, ASC, Microbiology, QR1-502
Abstract

The apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) is an adaptor molecule that mediates inflammatory and apoptotic signals. Legionella pneumophila (L. pneumophila) is an intracellular bacterium and the causative agent of Legionnaire’s pneumonia. L. pneumophila is able to cause pneumonia in immuno-compromised humans but not in most inbred mice. Murine macrophages that lack the ability to activate caspase-1, such as caspase-1-/- and Nlrc4-/- allow L. pneumophila infection. This permissiveness is attributed mainly to the lack of active caspase-1 and the absence of its down stream substrates such as caspase-7. However, the role of Asc in control of L. pneumophila infection in mice is unclear. Here we show that caspase-1 is moderately activated in Asc-/- macrophages and that this limited activation is required and sufficient to restrict L. pneumophila growth. Moreover, Asc-independent activation of caspase-1 requires bacterial flagellin and is mainly detected in cellular extracts but not in culture supernatants. We also demonstrate that the depletion of Asc from permissive macrophages enhances bacterial growth by promoting L. pneumophila-mediated activation of the NF-ĸB pathway and decreasing caspase-3 activation. Taken together, our data demonstrate that L. pneumophila infection in murine macrophages is controlled by several mechanisms: Asc-independent activation of caspase-1 and Asc-dependent regulation of NF-ĸB and caspase-3 activation.

Published
2011
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14. The inflammasome

Author

Amal O Amer

Subjects
Autophagy, Francisella, Legionella, Listeria, Salmonella, Inflammasome, Microbiology, QR1-502
Published
2011
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15. Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Author

Anwari Akhter, Mikhail A Gavrilin, Laura Frantz, Songcerae Washington, Cameron Ditty, Dominique Limoli, Colby Day, Anasuya Sarkar, Christie Newland, Jonathan Butchar, Clay B Marsh, Mark D Wewers, Susheela Tridandapani, Thirumala-Devi Kanneganti, and Amal O Amer

Subjects
Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
Abstract

Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and macrophages. Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1(-/-) derived macrophages. Particularly, caspase-1 activation is detected during L. pneumophila infection of murine macrophages while absent in human cells. Recent in vitro experiments demonstrate that caspase-7 is cleaved by caspase-1. However, the biological role for caspase-7 activation downstream of caspase-1 is not known. Furthermore, whether this reaction is pertinent to the apoptosis or to the inflammation pathway or whether it mediates a yet unidentified effect is unclear. Using the intracellular pathogen L. pneumophila, we show that, upon infection of murine macrophages, caspase-7 was activated downstream of the Nlrc4 inflammasome and required caspase-1 activation. Such activation of caspase-7 was mediated by flagellin and required a functional Naip5. Remarkably, mice lacking caspase-7 and its macrophages allowed substantial L. pneumophila replication. Permissiveness of caspase-7(-/-) macrophages to the intracellular pathogen was due to defective delivery of the organism to the lysosome and to delayed cell death during early stages of infection. These results reveal a new mechanism for caspase-7 activation downstream of the Nlrc4 inflammasome and present a novel biological role for caspase-7 in host defense against an intracellular bacterium.

Published
2009
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16. Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome

Author

Seongmi K. Russell, Jessica K. Harrison, Benjamin S. Olson, Hyung Joo Lee, Valerie P. O’Brien, Xiaoyun Xing, Jonathan Livny, Lu Yu, Elisha D. O. Roberson, Rajdeep Bomjan, Changxu Fan, Marina Sha, Shady Estfanous, Amal O. Amer, Marco Colonna, Thaddeus S. Stappenbeck, Ting Wang, Thomas J. Hannan, and Scott J. Hultgren

Subjects
Microbiology (medical), Immunology, Genetics, Cell Biology, Applied Microbiology and Biotechnology, Microbiology
Abstract

Previous urinary tract infections (UTIs) can predispose one to future infections; however, the underlying mechanisms affecting recurrence are poorly understood. We previously found that UTIs in mice cause differential bladder epithelial (urothelial) remodelling, depending on disease outcome, that impacts susceptibility to recurrent UTI. Here we compared urothelial stem cell (USC) lines isolated from mice with a history of either resolved or chronic uropathogenic Escherichia coli (UPEC) infection, elucidating evidence of molecular imprinting that involved epigenetic changes, including differences in chromatin accessibility, DNA methylation and histone modification. Epigenetic marks in USCs from chronically infected mice enhanced caspase-1-mediated cell death upon UPEC infection, promoting bacterial clearance. Increased Ptgs2os2 expression also occurred, potentially contributing to sustained cyclooxygenase-2 expression, bladder inflammation and mucosal wounding—responses associated with severe recurrent cystitis. Thus, UPEC infection acts as an epi-mutagen reprogramming the urothelial epigenome, leading to urothelial-intrinsic remodelling and training of the innate response to subsequent infection.

Published
2023

17. Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Author

Samuel Speaks, Ashley Zani, Abigail Solstad, Adam Kenney, Matthew I. McFadden, Lizhi Zhang, Adrian C. Eddy, Amal O. Amer, Richard Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, and Jacob S. Yount

Abstract

Influenza virus activates cellular inflammasome pathways, which can be either beneficial or detrimental to infection outcomes. Here, we investigated the role of the inflammasome-activated pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice significantly attenuated virus-induced weight loss, lung dysfunction, lung histopathology, and mortality compared with wild type (WT) mice, despite similar viral loads. Infected GSDMD KO mice exhibited decreased inflammatory gene signatures revealed by lung transcriptomics, which also implicated a diminished neutrophil response. Importantly, neutrophil depletion in infected WT mice recapitulated the reduced mortality and lung inflammation observed in GSDMD KO animals, while having no additional protective effects in GSDMD KOs. These findings reveal a new function for GSDMD in promoting lung neutrophil responses that amplify influenza virus-induced inflammation and pathogenesis. Targeting the GSDMD/neutrophil axis may provide a new therapeutic avenue for treating severe influenza.

Published
2023

18. Defective immunometabolism pathways in cystic fibrosis macrophages

Author

Cierra Carafice, Midhun N. K. Anne, Amal O. Amer, Xiaoli Zhang, Mostafa Eltobgy, Arwa Abu Khweek, Kathrin Krause, Mikhail A. Gavrilin, Shady Estfanous, Kylene Daily, Jeffrey R. Tonniges, Kaitlin Hamilton, Narasimham L. Parinandi, Asmaa Badr, and Daniel Baetzhold

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Cystic Fibrosis, Lipopolysaccharide, Burkholderia cenocepacia, Mitochondrion, medicine.disease_cause, Cystic fibrosis, Article, Microbiology, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Macrophage, chemistry.chemical_classification, Reactive oxygen species, biology, business.industry, Macrophages, Autophagy, Immune dysregulation, medicine.disease, biology.organism_classification, Mitochondria, Mice, Inbred C57BL, 030104 developmental biology, 030228 respiratory system, chemistry, Pediatrics, Perinatology and Child Health, business
Abstract

Background Mitochondria play a key role in immune defense pathways, particularly for macrophages. We and others have previously demonstrated that cystic fibrosis (CF) macrophages exhibit weak autophagy activity and exacerbated inflammatory responses. Previous studies have revealed that mitochondria are defective in CF epithelial cells, but to date, the connection between defective mitochondrial function and CF macrophage immune dysregulation has not been fully elucidated. Here, we present a characterization of mitochondrial dysfunction in CF macrophages. Methods Mitochondrial function in wild-type (WT) and CF F508del/F508del murine macrophages was measured using the Seahorse Extracellular Flux analyzer. Mitochondrial morphology was investigated using transmission electron and confocal microscopy. Mitochondrial membrane potential (MMP) as well as mitochondrial reactive oxygen species (mROS) were measured using TMRM and MitoSOX Red fluorescent dyes, respectively. All assays were performed at baseline and following infection by Burkholderia cenocepacia, a multi-drug resistant bacterium that causes detrimental infections in CF patients. Results We have identified impaired oxygen consumption in CF macrophages without and with B. cenocepacia infection. We also observed increased mitochondrial fragmentation in CF macrophages following infection. Lastly, we observed increased MMP and impaired mROS production in CF macrophages following infection with B. cenocepacia. Conclusions The mitochondrial defects identified are key components of the macrophage response to infection. Their presence suggests that mitochondrial dysfunction contributes to impaired bacterial killing in CF macrophages. Our current study will enhance our understanding of the pathobiology of CF and lead to the identification of novel mitochondrial therapeutic targets for CF.

Published
2021

19. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis

Author

Mostafa M. Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous, Eunsoo Kim, Asmaa Badr, Cierra Carafice, Kylene Daily, Owen Whitham, Maciej Pietrzak, Amy Webb, Jeffrey Kawahara, Adrian C. Eddy, Parker Denz, Mijia Lu, Mahesh KC, Mark E. Peeples, Jianrong Li, Jian Zhu, Jianwen Que, Richard Robinson, Oscar Rosas Mejia, Rachael E. Rayner, Luanne Hall-Stoodley, Stephanie Seveau, Mikhail A. Gavrilin, Xiaoli Zhang, Jeronay Thomas, Jacob E. Kohlmeier, Mehul S. Suthar, Eugene Oltz, Andrea Tedeschi, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Emily A. Hemann, Eman Abdelrazik, Adriana Forero, Shahid M. Nimjee, Prosper N. Boyaka, Estelle Cormet-Boyaka, Jacob S. Yount, and Amal O. Amer

Subjects
Mice, Knockout, Mice, Multidisciplinary, Thromboinflammation, SARS-CoV-2, Disease Progression, Animals, COVID-19, Humans, Lung, Severity of Illness Index, Caspases, Initiator
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health concern, and new treatment strategies are needed. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4) and its mouse homolog, caspase-11 (CASP11), are up-regulated in SARS–CoV-2 infections and that CASP4 expression correlates with severity of SARS–CoV-2 infection in humans. SARS–CoV-2–infected Casp11−/− mice were protected from severe weight loss and lung pathology, including blood vessel damage, compared to wild-type (WT) mice and mice lacking the caspase downstream effector gasdermin-D (Gsdmd−/−). Notably, viral titers were similar regardless of CASP11 knockout. Global transcriptomics of SARS–CoV-2–infected WT, Casp11−/−, and Gsdmd−/− lungs identified restrained expression of inflammatory molecules and altered neutrophil gene signatures in Casp11−/− mice. We confirmed that protein levels of inflammatory mediators interleukin (IL)-1β, IL-6, and CXCL1, as well as neutrophil functions, were reduced in Casp11−/− lungs. Additionally, Casp11−/− lungs accumulated less von Willebrand factor, a marker for endothelial damage, but expressed more Kruppel-Like Factor 2, a transcription factor that maintains vascular integrity. Overall, our results demonstrate that CASP4/11 promotes detrimental SARS–CoV-2–induced inflammation and coagulopathy, largely independently of GSDMD, identifying CASP4/11 as a promising drug target for treatment and prevention of severe COVID-19.

Published
2022

20. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages

Author

Asmaa Badr, Mostafa Eltobgy, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Kylene P. Daily, Arwa Abu Khweek, Ahmad Hegazi, Midhun N. K. Anne, Cierra Carafice, Frank Robledo-Avila, Youssra Saqr, Xiaoli Zhang, Tracey L. Bonfield, Mikhail A. Gavrilin, Santiago Partida-Sanchez, Stephanie Seveau, Estelle Cormet-Boyaka, and Amal O. Amer

Subjects
Microbiology (medical), autophagy, Burkholderia cenocepacia, Macrophages, Immunology, Cystic Fibrosis Transmembrane Conductance Regulator, lysosomal acidification, Burkholderia cenocepacia clearance, Hydrogen-Ion Concentration, CFTR modulators, Microbiology, QR1-502, cystic fibrosis, Mice, Infectious Diseases, Animals, Lysosomes, autophagosomes
Abstract

Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as Burkholderia cenocepacia. The autophagy process in CF (F508del) macrophages is halted, and the underlying mechanism remains unclear. Furthermore, the role of CFTR in maintaining the acidification of endosomal and lysosomal compartments in CF cells has been a subject of debate. Using 3D reconstruction of z-stack confocal images, we show that CFTR is recruited to LC3-labeled autophagosomes harboring B. cenocepacia. Using several complementary approaches, we report that CF macrophages display defective lysosomal acidification and degradative function for cargos destined to autophagosomes, whereas non-autophagosomal cargos are effectively degraded within acidic compartments. Notably, treatment of CF macrophages with CFTR modulators (tezacaftor/ivacaftor) improved the autophagy flux, lysosomal acidification and function, and bacterial clearance. In addition, CFTR modulators improved CFTR function as demonstrated by patch-clamp. In conclusion, CFTR regulates the acidification of a specific subset of lysosomes that specifically fuse with autophagosomes. Therefore, our study describes a new biological location and function for CFTR in autophago-lysosomes and clarifies the long-standing discrepancies in the field.

Published
2022

21. COLMAR Lipids Web Server and Ultrahigh-Resolution Methods for Two-Dimensional Nuclear Magnetic Resonance- and Mass Spectrometry-Based Lipidomics

Author

Lei Bruschweiler-Li, Abigail Leggett, Cheng Wang, Dawei Li, István Timári, Bo Zhang, Rafael Brüschweiler, Rachel E. Kopec, and Amal O. Amer

Subjects
0301 basic medicine, Magnetic Resonance Spectroscopy, 030102 biochemistry & molecular biology, Chemistry, General Chemistry, Mass spectrometry, Lipids, Biochemistry, Mass Spectrometry, Spectral line, NMR spectra database, 03 medical and health sciences, 030104 developmental biology, Metabolomics, Nuclear magnetic resonance, Lipidomics, Humans, Molecule, Caco-2 Cells, Spectroscopy, Heteronuclear single quantum coherence spectroscopy
Abstract

Accurate identification of lipids in biological samples is a key step in lipidomics studies. Multidimensional nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool for this purpose as it provides comprehensive structural information on lipid composition at atomic resolution. However, the interpretation of NMR spectra of complex lipid mixtures is currently hampered by limited spectral resolution and the absence of a customized lipid NMR database along with user-friendly spectral analysis tools. We introduce a new two-dimensional (2D) NMR metabolite database "COLMAR Lipids" that was specifically curated for hydrophobic metabolites presently containing 501 compounds with accurate experimental 2D 13C-1H heteronuclear single quantum coherence (HSQC) chemical shift data measured in CDCl3. A new module in the public COLMAR suite of NMR web servers was developed for the (semi)automated analysis of complex lipidomics mixtures (http://spin.ccic.osu.edu/index.php/colmarm/index2). To obtain 2D HSQC spectra with the necessary high spectral resolution along both 13C and 1H dimensions, nonuniform sampling in combination with pure shift spectroscopy was applied allowing the extraction of an abundance of unique cross-peaks belonging to hydrophobic compounds in complex lipidomics mixtures. As shown here, this information is critical for the unambiguous identification of underlying lipid molecules by means of the new COLMAR Lipids web server, also in combination with mass spectrometry, as is demonstrated for Caco-2 cell and lung tissue cell extracts.

Published
2020

23. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

Author

Emily Hemann, Mark E. Peeples, Eman Abdelrazik, Estelle Cormet-Boyaka, Asmaa Badr, Prosper N. Boyaka, Maciej Pietrzak, Shady Estfanous, Jeffrey Kawahara, Ashley Zani, Krishnan Mahesh, Adam D. Kenney, Jianrong Li, Oscar Rosas Mejia, Mostafa Eltobgy, Owen Whitham, Shahid M Nimjee, Richard T. Robinson, Andrea Tedeschi, Santiago Partida-Sanchez, Parker J. Denz, Frank Roberto, Adrian Eddy, Jacob S. Yount, Amy Webb, Cierra Carafice, Rachael E. Rayner, Eunsoo Kim, Mikhail A. Gavrilin, Kylene Daily, Jian Zhu, Amal O. Amer, Jianwen Que, Luanne Hall-Stoodley, Adriana Forero, Mijia Lu, and Stephanie Seveau

Subjects
Innate immune system, biology, Effector, business.industry, Caspase 4, Inflammation, CXCL1, medicine.anatomical_structure, Von Willebrand factor, Immunology, medicine, biology.protein, medicine.symptom, business, Transcription factor, Blood vessel
Abstract

SARS-CoV-2 is a worldwide health concern, and new treatment strategies are needed 1. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4), and its mouse homologue, caspase-11 (CASP11), are upregulated in SARS-CoV-2 infections, and that CASP4 expression correlates with severity of SARS-CoV-2 infection in humans. SARS-CoV-2-infected Casp11-/- mice were protected from severe weight loss and lung pathology, including blood vessel damage, compared to wild-type (WT) and gasdermin-D knock out (Gsdmd-/-) mice. GSDMD is a downstream effector of CASP11 and CASP1. Notably, viral titers were similar in the three genotypes. Global transcriptomics of SARS-CoV-2-infected WT, Casp11-/- and Gsdmd-/- lungs identified restrained expression of inflammatory molecules and altered neutrophil gene signatures in Casp11-/- mice. We confirmed that protein levels of inflammatory mediators IL-1β, IL6, and CXCL1, and neutrophil functions, were reduced in Casp11-/- lungs. Additionally, Casp11-/- lungs accumulated less von Willebrand factor, a marker for endothelial damage, but expressed more Kruppel-Like Factor 2, a transcription factor that maintains vascular integrity. Overall, our results demonstrate that CASP4/11, promotes detrimental SARS-CoV-2-associated inflammation and coagulopathy, largely independently of GSDMD, identifying CASP4/11 as a promising drug target for treatment and prevention of severe COVID-19.

Published
2021

24. Synovial fluid-induced aggregation occurs across Staphylococcus aureus clinical isolates and is mechanistically independent of attached biofilm formation

Author

Kurt B. Stevenson, Dana M Parker, Peter W Burback, Kenneth L. Urish, Daniel J. Wozniak, Amal O. Amer, Mostafa Eltobgy, Paul Stoodley, Shu-Hua Wang, and Amelia Staats

Subjects
Serum, Microbiology (medical), Staphylococcus aureus, Prosthesis-Related Infections, Physiology, medicine.drug_class, Antibiotics, medicine.disease_cause, Microbiology, Bacterial Adhesion, biofilm, Flow cytometry, Immune system, Synovial Fluid, joint, Synovial joint, Genetics, medicine, Animals, Humans, Synovial fluid, General Immunology and Microbiology, Ecology, medicine.diagnostic_test, biology, Chemistry, Synovial Membrane, aggregation, Biofilm, Cell Biology, Staphylococcal Infections, S. aureus, biology.organism_classification, QR1-502, infection, Infectious Diseases, medicine.anatomical_structure, Biofilms, orthopedics, Cattle, Hip Prosthesis, Knee Prosthesis, Bacteria, Research Article
Abstract

Rapid synovial fluid-induced aggregation of Staphylococcus aureus is currently being investigated as an important factor in the establishment of periprosthetic joint infections (PJIs). Pathogenic advantages of aggregate formation have been well documented in vitro, including recalcitrance to antibiotics and protection from host immune defenses. The objective of the present work was to determine the strain dependency of synovial fluid-induced aggregation by measuring the degree of aggregation of 21 clinical S. aureus isolates cultured from either PJI or bloodstream infections using imaging and flow cytometry. Furthermore, by measuring attached bacterial biomass using a conventional crystal violet assay, we assessed whether there is a correlation between the aggregative phenotype and surface-associated biofilm formation. While all of the isolates were stimulated to aggregate upon exposure to bovine synovial fluid (BSF) and human serum (HS), the extent of aggregation was highly variable between individual strains. Interestingly, the PJI isolates aggregated significantly more upon BSF exposure than those isolated from bloodstream infections. While we were able to stimulate biofilm formation with all of the isolates in growth medium, supplementation with either synovial fluid or human serum inhibited bacterial surface attachment over a 24 h incubation. Surprisingly, there was no correlation between the degree of synovial fluid-induced aggregation and quantity of surface-associated biofilm as measured by a conventional biofilm assay without host fluid supplementation. Taken together, our findings suggest that synovial fluid-induced aggregation appears to be widespread among S. aureus strains and mechanistically independent of biofilm formation. IMPORTANCE Bacterial infections of hip and knee implants are rare but devastating complications of orthopedic surgery. Despite a widespread appreciation of the considerable financial, physical, and emotional burden associated with the development of a prosthetic joint infection, the establishment of bacteria in the synovial joint remains poorly understood. It has been shown that immediately upon exposure to synovial fluid, the viscous fluid in the joint, Staphylococcus aureus rapidly forms aggregates which are resistant to antibiotics and host immune cell clearance. The bacterial virulence associated with aggregate formation is likely a step in the establishment of prosthetic joint infection, and as such, it has the potential to be a potent target of prevention. We hope that this work contributes to the future development of therapeutics targeting synovial fluid-induced aggregation to better prevent and treat these infections.

Published
2021

25. Bacterial infection drives trained immunity through epigenetic remodeling of epithelial stem cells

Author

Shady Estfanous, Jonathan Livny, Amal O. Amer, Ting Wang, Marco Colonna, Scott J. Hultgren, Seongmi Russell, Thomas J. Hannan, Lu Yu, Valerie P. O’Brien, Thaddeus S. Stappenbeck, Hyung Joo Lee, Elisha D.O. Roberson, and Benjamin Olson

Subjects
Immunity, Epigenetics, Biology, Stem cell, Cell biology
Abstract

Recurrent bacterial infections are a major health burden worldwide, yet the mechanisms dictating host susceptibility to recurrence are poorly understood. Here we demonstrate that an initial bacterial infection of the urinary bladder with uropathogenic E. coli (UPEC) can induce sustained epigenetic changes in the bladder epithelial (urothelial) stem cells that reprogram the differentiated urothelium. We established urothelial stem cell (USC) lines from isogenic mice with different urinary tract infection histories (naïve, chronic or self-resolving). Differentiation of the USC lines in Transwell culture resulted in polarized urothelial cultures that recapitulated distinct remodeling morphologies seen in vivo. In addition, we discovered differences in chromatin accessibility that segregated by disease history, resulting in differences in gene expression upon differentiation of the USC lines in vitro, based on ATAC-seq analysis of the USC lines. Differential basal expression of Caspase-1 led to divergent susceptibilities to inflammatory cell death upon UPEC infection. In mice with a history of chronic infection, enhanced caspase 1-mediated inflammatory cell death was found to be a protective response that enhanced bacterial clearance upon challenge infection. Thus, UPEC infection reshapes the epigenome leading to epithelial-intrinsic remodeling that trains the mucosal immune response to subsequent infection. These findings may have broad implications for the prevention of chronic/recurrent bacterial infections.

Published
2021

26. Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity

Author

Estelle Cormet-Boyaka, Shan-Lu Liu, Gourapura J. Renukaradhya, Jianrong Li, Abhay R. Satoskar, Shristi Ghimire, Sun Hee Kim, Eunsoo Kim, Cong Zeng, Namal P.M. Liyanage, Rachel M. Woodfint, Rajni Kant Shukla, Zayed Attia, Amal O. Amer, Haley Steiner, and Prosper N. Boyaka

Subjects
Immunoglobulin A, Swine, T cell, medicine.medical_treatment, neutrophil elastase inhibitor, chemical and pharmacologic phenomena, Antibodies, Viral, Microbiology, Epitope, Mice, Adjuvants, Immunologic, Immunity, elastase, Animals, Humans, Medicine, Enzyme Inhibitors, Immunity, Mucosal, Mice, Knockout, Multidisciplinary, biology, SARS-CoV-2, business.industry, Elastase, COVID-19, Biological Sciences, Th1 Cells, Antibodies, Neutralizing, Immunity, Innate, COVID-19 Drug Treatment, Mice, Inbred C57BL, HEK293 Cells, medicine.anatomical_structure, alum, Neutrophil elastase, Antibody Formation, Spike Glycoprotein, Coronavirus, Immunology, biology.protein, mucosal immunity, Alum Compounds, Antibody, Leukocyte Elastase, business, Adjuvant
Abstract

Significance We report that suppression of the serine protease elastase reshapes innate responses induced by injected vaccines containing alum adjuvant. This reprogramming improves the induction of protective antibodies in the bloodstream and stimulates innate signals, which support the development of antibody responses in mucosal tissues. Our findings identify elastase as the innate regulator that blunts the adjuvant activity of alum. They also demonstrate that vaccination via mucosal routes is not an absolute requirement for antibody responses in mucosal tissues and secretions. Supplementation of an alum-based vaccine containing SARS-CoV-2 spike protein subunit 1 as antigen increased anti–SARS-CoV-2 immunity in the blood and mucosal secretions in mice. Thus, this strategy could help in the development of future protein-based vaccines against SARS-CoV-2., Alum, used as an adjuvant in injected vaccines, promotes T helper 2 (Th2) and serum antibody (Ab) responses. However, it fails to induce secretory immunoglobulin (Ig) A (SIgA) in mucosal tissues and is poor in inducing Th1 and cell-mediated immunity. Alum stimulates interleukin 1 (IL-1) and the recruitment of myeloid cells, including neutrophils. We investigated whether neutrophil elastase regulates the adjuvanticity of alum, and whether a strategy targeting neutrophil elastase could improve responses to injected vaccines. Mice coadministered a pharmacological inhibitor of elastase, or lacking elastase, developed high-affinity serum IgG and IgA antibodies after immunization with alum-adsorbed protein vaccines, including the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2). These mice also developed broader antigen-specific CD4+ T cell responses, including high Th1 and T follicular helper (Tfh) responses. Interestingly, in the absence of elastase activity, mucosal SIgA responses were induced after systemic immunization with alum as adjuvant. Importantly, lack or suppression of elastase activity enhanced the magnitude of anti–SARS-CoV-2 spike subunit 1 (S1) antibodies, and these antibodies reacted with the same epitopes of spike 1 protein as sera from COVID-19 patients. Therefore, suppression of neutrophil elastase could represent an attractive strategy for improving the efficacy of alum-based injected vaccines for the induction of broad immunity, including mucosal immunity.

Published
2021

27. Hofbauer Cells Spread <named-content content-type='genus-species'>Listeria monocytogenes</named-content> among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors

Author

Kara M. Rood, Lauren J. Johnson, Xiaoli Zhang, Stephanie Seveau, Siavash Azari, Sophia M Kozlowski, Amy Webb, and Amal O. Amer

Subjects
Chemokine, placenta, THP-1 Cells, macrophage polarization, Inflammation, Biology, fetal tolerance, Microbiology, Pregnancy, Virology, Placenta, medicine, Humans, Cells, Cultured, Fetus, Innate immune system, Macrophages, Trophoblast, Acquired immune system, Listeria monocytogenes, infection, QR1-502, Trophoblasts, medicine.anatomical_structure, Hofbauer cells, inflammation, Immunology, embryonic structures, biology.protein, Cytokines, Chorionic villi, Female, Chemokines, medicine.symptom, RNA-seq, transcriptome, Research Article
Abstract

Pregnant women are highly susceptible to infection by the bacterial pathogen Listeria monocytogenes, leading to miscarriage, premature birth, and neonatal infection. L. monocytogenes is thought to breach the placental barrier by infecting trophoblasts at the maternal/fetal interface. However, the fate of L. monocytogenes within chorionic villi and how infection reaches the fetus are unsettled. Hofbauer cells (HBCs) are fetal placental macrophages and the only leukocytes residing in healthy chorionic villi, forming a last immune barrier protecting fetal blood from infection. Little is known about the HBCs’ antimicrobial responses to pathogens. Here, we studied L. monocytogenes interaction with human primary HBCs. Remarkably, despite their M2 anti-inflammatory phenotype at basal state, HBCs phagocytose and kill non-pathogenic bacteria like Listeria innocua and display low susceptibility to infection by L. monocytogenes. However, L. monocytogenes can exploit HBCs to spread to surrounding placental cells. Transcriptomic analyses by RNA sequencing revealed that HBCs undergo pro-inflammatory reprogramming upon L. monocytogenes infection, similarly to macrophages stimulated by the potent M1-polarizing agents lipopolysaccharide (LPS)/interferon gamma (IFN-γ). Infected HBCs also express pro-inflammatory chemokines known to promote placental infiltration by maternal leukocytes. However, HBCs maintain the expression of a collection of tolerogenic genes and secretion of tolerogenic cytokines, consistent with their tissue homeostatic role in prevention of fetal rejection. In conclusion, we propose a previously unrecognized model in which HBCs promote the spreading of L. monocytogenes among placental cells and transition to a pro-inflammatory state likely to favor innate immune responses, while maintaining the expression of tolerogenic factors known to prevent maternal anti-fetal adaptive immunity. IMPORTANCE Infection of the placental/fetal unit by the facultative intracellular pathogen Listeria monocytogenes results in severe pregnancy complications. Hofbauer cells (HBCs) are fetal macrophages that play homeostatic anti-inflammatory functions in healthy placentas. HBCs are located in chorionic villi between the two cell barriers that protect fetal blood from infection: trophoblast cells at the maternal interface (in contact with maternal blood), and fetal endothelial cells at the fetal interface (in contact with fetal blood). As the only leukocytes residing in chorionic villi, HBCs form a critical immune barrier protecting the fetus from infection. Here, we show that although HBCs display low susceptibility to L. monocytogenes, the bacterium still replicates intracellularly and can spread to other placental and fetal cells. We propose that HBCs are permissive to L. monocytogenes transplacental propagation and can repolarize toward a pro-inflammatory phenotype upon infection. However, consistent with their placental homeostatic functions, repolarized HBCs maintain the expression of tolerogenic factors known to prevent maternal anti-fetal adaptive immunity, at least at early stages of infection.

Published
2021

28. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor

Author

Shuzhong Zhang, Chandra L. Shrestha, Frank Robledo-Avila, Devi Jaganathan, Benjamin L. Wisniewski, Nevian Brown, Hanh Pham, Katherine Carey, Amal O. Amer, Luanne Hall-Stoodley, Karen S. McCoy, Shasha Bai, Santiago Partida-Sanchez, and Benjamin T. Kopp

Subjects
Pulmonary and Respiratory Medicine
Abstract

BackgroundAbnormal macrophage function caused by dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway infections and inflammation in people with cystic fibrosis (PWCF). Elexacaftor/tezacaftor/ivacaftor (ETI) is a new CFTR modulator therapy for PWCF. Host–pathogen and clinical responses to CFTR modulators are poorly described. We sought to determine how ETI impacts macrophage CFTR function, resulting effector functions and relationships to clinical outcome changes.MethodsClinical information and/or biospecimens were obtained at ETI initiation and 3, 6, 9 and 12 months post-ETI in 56 PWCF and compared with non-CF controls. Peripheral blood monocyte-derived macrophages (MDMs) were isolated and functional assays performed.ResultsETI treatment was associated with increased CF MDM CFTR expression, function and localisation to the plasma membrane. CF MDM phagocytosis, intracellular killing of CF pathogens and efferocytosis of apoptotic neutrophils were partially restored by ETI, but inflammatory cytokine production remained unchanged. Clinical outcomes including increased forced expiratory volume in 1 s (+10%) and body mass index (+1.0 kg·m−2) showed fluctuations over time and were highly individualised. Significant correlations between post-ETI MDM CFTR function and sweat chloride levels were observed. However, MDM CFTR function correlated with clinical outcomes better than sweat chloride.ConclusionETI is associated with unique changes in innate immune function and clinical outcomes.

Published
2022

29. Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Author

Shady Estfanous, Kylene P. Daily, Mostafa Eltobgy, Nicholas P. Deems, Midhun N. K. Anne, Kathrin Krause, Asmaa Badr, Kaitlin Hamilton, Cierra Carafice, Ahmad Hegazi, Arwa Abu Khweek, Hesham Kelani, Shahid Nimjee, Hamdy Awad, Xiaoli Zhang, Estelle Cormet-Boyaka, Hesham Haffez, Sameh Soror, Adel Mikhail, Gerard Nuovo, Ruth M. Barrientos, Mikhail A. Gavrilin, and Amal O. Amer

Subjects
0301 basic medicine, Male, autophagy, Immunology, microglia, In situ hybridization, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, In vivo, Alzheimer Disease, microRNA, medicine, Immunology and Allergy, Animals, Humans, Amyloid-β, Receptor, Original Research, Amyloid beta-Peptides, Microglia, Chemistry, Autophagy, Mir17-92a, NBR1, RC581-607, In vitro, Cell biology, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, nervous system, Proteolysis, Female, Immunologic diseases. Allergy, Alzheimer’s disease, 030217 neurology & neurosurgery
Abstract

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer’s Disease (AD), though mechanisms underlying this dysfunction remain elusive. Here, primary microglia from adult AD (5xFAD) mice were utilized to demonstrate that 5xFAD microglia fail to degrade Aβ and express low levels of autophagy cargo receptor NBR1. In 5xFAD mouse brains, we show for the first time that AD microglia express elevated levels of microRNA cluster Mirc1/Mir17-92a, which is known to downregulate autophagy proteins. By in situ hybridization in post-mortem AD human tissue sections, we observed that the Mirc1/Mir17-92a cluster member miR-17 is also elevated in human AD microglia, specifically in the vicinity of Aβ deposits, compared to non-disease controls. We show that NBR1 expression is negatively correlated with expression of miR-17 in human AD microglia via immunohistopathologic staining in human AD brain tissue sections. We demonstrate in healthy microglia that autophagy cargo receptor NBR1 is required for Aβ degradation. Inhibiting elevated miR-17 in 5xFAD mouse microglia improves Aβ degradation, autophagy, and NBR1 puncta formation in vitro and improves NBR1 expression in vivo. These findings offer a mechanism behind dysfunctional autophagy in AD microglia which may be useful for therapeutic interventions aiming to improve autophagy function in AD.

Published
2021

30. Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

Author

Shady Estfanous, Amal O. Amer, Sameh H. Soror, Daniel Baetzhold, Midhun N. K. Anne, Kyle Caution, Mostafa Eltobgy, Hesham Haffez, Mikhail A. Gavrilin, Kylene Daily, Haitao Wen, Kathrin Krause, Asmaa Badr, Tianliang Li, Xiaoli Zhang, Arwa Abu Khweek, Kaitlin Hamilton, and Cierra Carafice

Subjects
Multidisciplinary, Burkholderia cenocepacia, In vivo, Science, Medicine, Gasdermin D, Biology, biology.organism_classification, In vitro, Microbiology
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2021

31. Methylomic correlates of autophagy activity in cystic fibrosis

Author

Shady Estfanous, Estelle Cormet-Boyaka, Asmaa Badr, Alexander Pan, Mark E. Drew, Anup Vaidya, Kathrin Krause, Kylene Daily, Ralf Bundschuh, Pearlly S. Yan, Mikhail A. Gavrilin, Kyle Caution, Hawin Gosu, Kaitlin Hamilton, Duaa Dakhlallah, Amal O. Amer, Xi Chen, and David Frankhouser

Subjects
Proteomics, 0301 basic medicine, Pulmonary and Respiratory Medicine, Low protein, Cystic Fibrosis, Burkholderia cenocepacia, Cystic fibrosis, Article, ATG12, 03 medical and health sciences, 0302 clinical medicine, Immune system, Humans, Medicine, biology, business.industry, Autophagy, Methylation, biology.organism_classification, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Cell biology, 030104 developmental biology, 030228 respiratory system, Pediatrics, Perinatology and Child Health, biology.protein, business
Abstract

Autophagy is a highly regulated, biological process that provides energy during periods of stress and starvation. This conserved process also acts as a defense mechanism and clears microbes from the host cell. Autophagy is impaired in Cystic Fibrosis (CF) patients and CF mice, as their cells exhibit low expression levels of essential autophagy molecules. The genetic disorder in CF is due to mutations in the cystic fibrosis transmembrane conductance regulator (cftr) gene that encodes for a chloride channel. CF patients are particularly prone to infection by pathogens that are otherwise cleared by autophagy in healthy immune cells including Burkholderia cenocepacia (B. cenocepacia). The objective of this study is to determine the mechanism underlying weak autophagic activity in CF macrophages and find therapeutic targets to correct it. Using reduced representation bisulfite sequencing (RRBS) to determine DNA methylation profile, we found that the promoter regions of Atg12 in CF macrophages are significantly more methylated than in the wild-type (WT) immune cells, accompanied by low protein expression. The natural product epigallocatechin-3-gallate (EGCG) significantly reduced the methylation of Atg12 promoter improving its expression. Accordingly, EGCG restricted B. cenocepacia replication within CF mice and their derived macrophages by improving autophagy and preventing dissemination. In addition, EGCG improved the function of CFTR protein. Altogether, utilizing RRBS for the first time in the CF field revealed a previously unrecognized mechanism for reduced autophagic activity in CF. Our data also offers a mechanism by which EGCG exerts its positive effects in CF.

Published
2019

32. Intermittent Lipopolysaccharide Exposure Significantly Increases Cortical Infarct Size and Impairs Autophagy

Author

Candice M. Brown, John Z. Cavendish, Heng Hu, Amal O. Amer, James W. Simpkins, Xuefang Ren, Ali Rai, Ahmad Dakhlallah, Mya E Vannoy, Duaa Dakhlallah, Ashley E. Russell, and Clay B. Marsh

Subjects
0301 basic medicine, Lipopolysaccharides, medicine.medical_specialty, autophagy, LPS, Lipopolysaccharide, lcsh:RC321-571, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Internal medicine, Diabetes mellitus, medicine, Animals, cardiovascular diseases, RNA, Messenger, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Stroke, Original Paper, DNA methylation, business.industry, Tumor Necrosis Factor-alpha, General Neuroscience, Autophagy, medicine.disease, Thrombosis, stroke, 030104 developmental biology, Endocrinology, chemistry, Infarction, TNF-α, Tumor necrosis factor alpha, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Globally, stroke is a leading cause of death and disability. Traditional risk factors like hypertension, diabetes, and obesity do not fully account for all stroke cases. Recent infection is regarded as changes in systemic immune signaling, which can increase thrombosis formation and other stroke risk factors. We have previously shown that administration of lipopolysaccharide (LPS) 30-minutes prior to stroke increases in infarct volume. In the current study, we found that animals intermittently exposed to LPS have larger cortical infarcts when compared to saline controls. To elucidate the mechanism behind this phenomenon, several avenues were investigated. We observed significant upregulation of tumor necrosis factor-alpha (TNF-α) mRNA, especially in the ipsilateral hemisphere of both saline and LPS exposed groups compared to sham surgery animals. We also observed significant reductions in expression of genes involved in autophagy in the ipsilateral hemisphere of LPS stroke animals. In addition, we assessed DNA methylation of autophagy genes and observed a significant increase in the ipsilateral hemisphere of LPS stroke animals. Intermittent exposure to LPS increases cortical infarct volume, downregulates autophagy genes, and induces hypermethylation of the corresponding CpG islands. These data suggest that intermittent immune activation may deregulate epigenetic mechanisms and promote neuropathological outcomes after stroke.

Published
2021

33. Caspase-11 regulates lung inflammation in response to house dust mites

Author

Shady Estfanous, Midhun N. K. Anne, Kara N. Corps, Kathrin Krause, Mostafa Eltobgy, Cierra Carafice, Zayed Attia, Kylene Daily, Eunsoo Kim, Prosper N. Boyaka, Kaitlin Hamilton, Mikhail A. Gavrilin, Asmaa Badr, Arwa Abu Khweek, Marisa R. Joldrichsen, Xiaoli Zhang, and Amal O. Amer

Subjects
Immunology, Inflammation, Caspase-11, Immunoglobulin E, Article, Allergic inflammation, Allergic sensitization, Mice, medicine, Hypersensitivity, Animals, Sensitization, CD86, Mice, Knockout, biology, Pyroglyphidae, Inflammasome, Pneumonia, respiratory system, Caspases, Initiator, respiratory tract diseases, Mice, Inbred C57BL, medicine.anatomical_structure, biology.protein, medicine.symptom, medicine.drug
Abstract

Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen or danger-associated molecular patterns (PAMPs or DAMPs). Murine caspase-11 engages the noncanonical inflammasome. We addressed the role of caspase-11 in mediating host responses to HDM and subsequent allergic inflammation using caspase-11-/- mice, which lack caspase-11 while express caspase-1. We found that HDM induce caspase-11 expression in vitro. The presence of IL-4 and IL-13 promote caspase-11 expression. Additionally, caspase-11-/- macrophages show reduced release of IL-6, IL-12, and KC, and express lower levels of costimulatory molecules (e.g., CD40, CD86 and MHCII) in response to HDM stimulation. Notably, HDM sensitization of caspase-11-/- mice resulted in similar levels of IgE responses and hypothermia in response to nasal HDM challenge compared to WT. However, analysis of cell numbers and cytokines in bronchiolar alveolar lavage fluid (BALF) and histopathology of representative lung segments demonstrate altered inflammatory responses and reduced neutrophilia in the airways of the caspase-11-/- mice. These findings indicate that caspase-11 regulates airway inflammation in response to HDM exposure.

Published
2021

34. Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo

Author

Kylene Daily, Haitao Wen, Mostafa Eltobgy, Hesham Haffez, Amal O. Amer, Tianliang Li, Kathrin Krause, Kaitlin Hamilton, Shady Estfanous, Mikhail A. Gavrilin, Sameh H. Soror, Midhun N. K. Anne, Arwa Abu Khweek, Daniel Baetzhold, Kyle Caution, Asmaa Badr, Cierra Carafice, and Xiaoli Zhang

Subjects
Lipopolysaccharides, Male, 0301 basic medicine, Necrosis, Burkholderia cenocepacia, Molecular biology, Inflammasomes, medicine.medical_treatment, Diseases, Mice, 0302 clinical medicine, Pathogen, Mice, Knockout, Multidisciplinary, Cell Death, Intracellular Signaling Peptides and Proteins, Burkholderia Infections, Inflammasome, Caspases, Initiator, Mitochondria, CXCL1, Cytokine, 030220 oncology & carcinogenesis, Medicine, Female, medicine.symptom, medicine.drug, Cell biology, Science, Immunology, Inflammation, Biology, Microbiology, Article, 03 medical and health sciences, Autophagy, medicine, Animals, Author Correction, Macrophages, Phosphate-Binding Proteins, biology.organism_classification, Mice, Inbred C57BL, 030104 developmental biology, Reactive Oxygen Species
Abstract

Burkholderia cenocepacia (B. cenocepacia) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals including cystic fibrosis patients. The lack of gasdermin D (GSDMD) protects mice against endotoxin lipopolysaccharide (LPS) shock. On the other hand, GSDMD promotes mice survival in response to certain bacterial infections. However, the role of GSDMD during B. cenocepacia infection is not yet determined. Our in vitro study shows that GSDMD restricts B. cenocepacia replication within macrophages independent of its role in cell death through promoting mitochondrial reactive oxygen species (mROS) production. mROS is known to stimulate autophagy, hence, the inhibition of mROS or the absence of GSDMD during B. cenocepacia infections reduces autophagy which plays a critical role in the restriction of the pathogen. GSDMD promotes inflammation in response to B. cenocepacia through mediating the release of inflammasome dependent cytokine (IL-1β) and an independent one (CXCL1) (KC). Additionally, different B. cenocepacia secretory systems (T3SS, T4SS, and T6SS) contribute to inflammasome activation together with bacterial survival within macrophages. In vivo study confirmed the in vitro findings and showed that GSDMD restricts B. cenocepacia infection and dissemination and stimulates autophagy in response to B. cenocepacia. Nevertheless, GSDMD promotes lung inflammation and necrosis in response to B. cenocepacia without altering mice survival. This study describes the double-edged functions of GSDMD in response to B. cenocepacia infection and shows the importance of GSDMD-mediated mROS in restriction of B. cenocepacia.

Published
2021

36. Insights Into Mucosal Innate Immune Responses in House Dust Mite-Mediated Allergic Asthma

Author

Arwa Abu Khweek, Eunsoo Kim, Marisa R. Joldrichsen, Amal O. Amer, and Prosper N. Boyaka

Subjects
0301 basic medicine, lcsh:Immunologic diseases. Allergy, Allergy, Dermatophagoides pteronyssinus, Immunology, mucosal, Inflammation, Review, Allergic sensitization, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Animals, Humans, Immunology and Allergy, Medicine, Antigens, Dermatophagoides, Immunity, Mucosal, innate immunity, house dust mite, Asthma, House dust mite, Innate immune system, biology, business.industry, asthma, medicine.disease, biology.organism_classification, Acquired immune system, allergy, Immunity, Innate, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, medicine.symptom, business, lcsh:RC581-607
Abstract

The prevalence of asthma has been rising steadily for several decades, and continues to be a major public health and global economic burden due to both direct and indirect costs. Asthma is defined as chronic heterogeneous inflammatory diseases characterized by airway obstruction, mucus production and bronchospasm. Different endotypes of asthma are being recognized based on the distinct pathophysiology, genetic predisposition, age, prognosis, and response to remedies. Mucosal innate response to environmental triggers such as pollen, cigarette smoke, fragrances, viral infection, and house dust mite (HDM) are now recognized to play an important role in allergic asthma. HDM are the most pervasive allergens that co-habitat with us, as they are ubiquitous in-house dusts, mattress and bedsheets, and feed on a diet of exfoliated human skin flakes. Dermatophagoides pteronyssinus, is one among several HDM identified up to date. During the last decade, extensive studies have been fundamental in elucidating the interactions between HDM allergens, the host immune systems and airways. Moreover, the paradigm in the field of HDM-mediated allergy has been shifted away from being solely a Th2-geared to a complex response orchestrated via extensive crosstalk between the epithelium, professional antigen presenting cells (APCs) and components of the adaptive immunity. In fact, HDM have several lessons to teach us about their allergenicity, the complex interactions that stimulate innate immunity in initiating and perpetuating the lung inflammation. Herein, we review main allergens of Dermatophagoides pteronyssinus and their interactions with immunological sentinels that promote allergic sensitization and activation of innate immunity, which is critical for the development of the Th2 biased adaptive immunity to HDM allergens and development of allergic asthma.

Published
2020

38. Pyroptotic and non‐pyroptotic effector functions of caspase‐11

Author

Arwa Abu Khweek and Amal O. Amer

Subjects
0301 basic medicine, danger‐associated molecular patterns, Inflammasomes, Burkholderia, Immunology, Caspase 1, caspase‐1, Legionella, Caspase-11, Proinflammatory cytokine, Mice, 03 medical and health sciences, 0302 clinical medicine, caspase‐11, Salmonella, medicine, Animals, Immunology and Allergy, Invited Reviews, pathogen‐associated molecular patterns, Caspase, Mice, Knockout, Innate immune system, Invited Review, biology, Pathogen-associated molecular pattern, pyroptosis, Pyroptosis, Inflammasome, Caspases, Initiator, Cell biology, 030104 developmental biology, Caspases, gasdermin, biology.protein, 030215 immunology, medicine.drug
Abstract

Innate immune cells, epithelial cells, and many other cell types are capable of detecting infection or tissue injury, thus mounting regulated immune response. Inflammasomes are highly sophisticated and effective orchestrators of innate immunity. These oligomerized multiprotein complexes are at the center of various innate immune pathways, including modulation of the cytoskeleton, production and maturation of cytokines, and control of bacterial growth and cell death. Inflammasome assembly often results in caspase‐1 activation, which is an inflammatory caspase that is involved in pyroptotic cell death and release of inflammatory cytokines in response to pathogen patterns and endogenous danger stimuli. However, the nature of stimuli and inflammasome components are diverse. Caspase‐1 activation mediated release of mature IL‐1β and IL‐18 in response to canonical stimuli initiated by NOD‐like receptor (NLR), and apoptosis‐associated speck‐like protein containing a caspase recruitment domain (ASC). On the other hand, caspase‐11 delineates a non‐canonical inflammasome that promotes pyroptotic cell death and non‐pyroptotic functions in response to non‐canonical stimuli. Caspase‐11 in mice and its homologues in humans (caspase‐4/5) belong to caspase‐1 family of cysteine proteases, and play a role in inflammation. Knockout mice provided new genetic tools to study inflammatory caspases and revealed the role of caspase‐11 in mediating septic shock in response to lethal doses of lipopolysaccharide (LPS). Recognition of LPS mediates caspase‐11 activation, which promotes a myriad of downstream effects that include pyroptotic and non‐pyroptotic effector functions. Therefore, the physiological functions of caspase‐11 are much broader than its previously established roles in apoptosis and cytokine maturation. Inflammation induced by exogenous or endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage. Consequently, the existence of sophisticated mechanisms that tightly regulate the specificity and sensitivity of inflammasome pathways provides a fine‐tuning balance between adequate immune response and minimal tissue damage. In this review, we summarize effector functions of caspase‐11.

Published
2020

39. Caspase-11 regulates lung inflammation in response to house dust mites

Author

Arwa Abu khweek, Marisa R. Joldrichsen, Eunsoo Kim, Zayed Attia, Kathrin Krause, Kylene Daily, Shady Estfanous, Kaitlin Hamilton, Asmaa Badr, Midhun N. K. Anne, Mostafa Eltobgy, Cierra Carafice, Xiaoli Zhang, Mikhail A. Gavrilin, Prosper N. Boyaka, and Amal O. Amer

Subjects
respiratory system
Abstract

Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen or danger-associated molecular patterns (PAMPs or DAMPs). Murine caspase-11 engages the noncanonical inflammasome. We addressed the role of caspase-11 in mediating host responses to HDM and subsequent allergic inflammation using caspase-11−/− mice, which lack caspase-11 while express caspase-1. We found that HDM induce caspase-11 expression in vitro. The presence of IL-4 and IL-13 promotes caspase-11 expression. Additionally, caspase-11−/− macrophages show reduced release of (KC, IL-6 and IL-12) cytokines, and express lower levels of costimulatory molecules (e.g., CD40, CD86 and MHCII) in response to HDM stimulation. Notably, HDM sensitization of caspase-11−/− mice resulted in similar levels of IgE responses and hypothermia in response to nasal HDM challenge compared to WT. However, analysis of cell numbers and cytokines in bronchiolar alveolar fluid (BALF), as well as histological lung tissue showed altered inflammatory responses and reduced neutrophilia in the airways of the caspase-11−/− mice. These findings indicate that caspase-11 regulates airway inflammation in response to HDM exposure.

Published
2020

40. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia

Author

Brian M. M. Ahmer, Liwen Zhang, Vincenzo Coppola, Qingjun Liu, Na Tang, R. Marshall Pope, Yizhi Xiao, Hui Guo, Jian Zhang, Guoxin Lin, Daniel J. Wozniak, Lijian Tao, Chengkai Yan, Murugesan V. S. Rajaram, Sha Tu, Amal O. Amer, Juan Tang, John S. Gunn, Wallace Y. Langdon, Stanley Lipkowitz, Jordi B. Torrelles, and Ling Huang

Subjects
Male, 0301 basic medicine, Proteasome Endopeptidase Complex, Inflammasomes, Ubiquitin-Protein Ligases, Innate Immunity and Inflammation, Immunology, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Immunology and Allergy, Proto-Oncogene Proteins c-cbl, Adaptor Proteins, Signal Transducing, integumentary system, biology, Extramural, Chemistry, Ubiquitination, Signal transducing adaptor protein, Inflammasome, Endotoxemia, Cell biology, Ubiquitin ligase, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Female, NLRP3 inflammasome activation, medicine.drug
Abstract

Hyper-activation of NLRP3 inflammasomes contributes to the development of endotoxemia, but the molecular mechanisms are poorly defined. Tang et al. demonstrate that sequential ubiquitination of NLRP3 is crucial to keep NLRP3 inflammasomes in check and limits endotoxemia., Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS via a caspase-11/NLRP3–dependent manner. Further studies show that NLRP3 undergoes both K63- and K48-linked polyubiquitination. Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. We also identify RNF125 as an additional E3 ubiquitin ligase that initiates K63-linked ubiquitination of the NLRP3 LRR domain. Therefore, NLRP3 is sequentially ubiquitinated by K63- and K48-linked ubiquitination, thus keeping the NLRP3 inflammasomes in check and restraining endotoxemia.

Published
2020

41. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

Author

Anup Vaidya, Kylene Daily, Midhun N. K. Anne, Mikhail A. Gavrilin, Sudha Argwal, Asmaa Badr, Frank Robledo-Avila, Wael N. Jarjour, Arwa Abu Khweek, Kathrin Krause, Shady Estfanous, Xiaoli Zhang, Nicholas A. Young, Kaitlin Hamilton, Santiago Partida-Sanchez, Hawin Gosu, Mostafa Eltobgy, Duaa Dakhlallah, Amal O. Amer, and Kyle Caution

Subjects
0301 basic medicine, cell migration, Inflammasomes, caspase-11, medicine.medical_treatment, Arthritis, Gene Expression, Extracellular Traps, Mice, 0302 clinical medicine, neutrophils, Immunology and Allergy, Phosphorylation, Original Research, Mice, Knockout, Chemistry, Arthritis, Gouty, Chemotaxis, NETosis, Inflammasome, Immunohistochemistry, Caspases, Initiator, 3. Good health, Cell biology, macrophages, Cytokine, Actin Depolymerizing Factors, IL-1β, Receptor-Interacting Protein Serine-Threonine Kinases, Acute Disease, Cytokines, Tumor necrosis factor alpha, Disease Susceptibility, medicine.symptom, Inflammation Mediators, medicine.drug, Signal Transduction, lcsh:Immunologic diseases. Allergy, Immunology, Inflammation, Caspase-11, Immunophenotyping, 03 medical and health sciences, gout, inflammasome, medicine, Animals, Innate immune system, Neutrophil extracellular traps, medicine.disease, Disease Models, Animal, 030104 developmental biology, lcsh:RC581-607, Protein Kinases, Biomarkers, 030215 immunology
Abstract

Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses are the primary drivers for tissue destruction and inflammation in gout. MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1β and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes. Here, we show that caspase-11 -/- mice and their derived macrophages produce significantly reduced levels of gout-specific cytokines including IL-1β, TNFα, IL-6, and KC, while others like IFNγ and IL-12p70 are not altered. IL-1β induces the expression of caspase-11 in an IL-1 receptor-dependent manner in macrophages contributing to the priming of macrophages during sterile inflammation. The absence of caspase-11 reduced the ability of macrophages and neutrophils to migrate in response to exogenously injected KC in vivo. Notably, in vitro, caspase-11 -/- neutrophils displayed random migration in response to a KC gradient when compared to their WT counterparts. This phenotype was associated with altered cofilin phosphorylation. Unlike their wild-type counterparts, caspase-11 -/- neutrophils also failed to produce neutrophil extracellular traps (NETs) when treated with MSU. Together, this is the first report demonstrating that caspase-11 promotes neutrophil directional trafficking and function in an acute model of gout. Caspase-11 also governs the production of inflammasome-dependent and -independent cytokines from macrophages. Our results offer new, previously unrecognized functions for caspase-11 in macrophages and neutrophils that may apply to other neutrophil-mediated disease conditions besides gout.

Published
2019

42. Microglial autophagy-mediated clearance of amyloid-beta plaques is dysfunctional in Alzheimer’s Disease mice

Author

Kylene P Daily and Amal O Amer

Subjects
Immunology, Immunology and Allergy
Abstract

Alzheimer’s Disease (AD) is a neurodegenerative disorder with no preventative methods or cure. Deposition of aggregated amyloid-beta (Aβ) in the brain is hypothesized to initiate a vicious cascade, leading to inflammation and tissue damage. Microglia are brain-resident immune cells which help maintain homeostasis and clear protein aggregates, including Aβ. However, in AD, microglia produce inflammatory mediators and do not adequately clear Aβ. This project seeks to determine how healthy microglia clear Aβ from the brain and why diseased AD microglia do not. Autophagy is a homeostatic process providing the cell with energy during stress. Autophagy can act as a defense mechanism, by clearing foreign particles and defective proteins. Previous research on AD established that autophagy is dysfunctional in neurons, but autophagy is not well-characterized in AD microglia. Functional autophagy requires expression of multiple autophagy proteins. We hypothesized that AD microglia fail to clear Aβ due to reduced expression of autophagy proteins and that restoring expression of these proteins will enhance autophagy activity. Utilizing microglia from adult AD model mice and various autophagy mice, we demonstrated that AD microglia do not degrade Aβ due to reduced expression of autophagy proteins, which are necessary for Aβ degradation. We identified an upregulated cluster of microRNA in microglia from mouse and human AD brain tissue samples. Inhibiting these microRNA improves expression of specific autophagy proteins and restores Aβ degradation in AD mouse microglia. Our findings indicate that autophagy is dysfunctional in AD microglia and establish a mechanism behind dysfunctional autophagy which may be therapeutically targeted.

Published
2021

43. Caspase‐11 counteracts mitochondrial ROS‐mediated clearance of Staphylococcus aureus in macrophages

Author

Vijay Pancholi, Midhun N. K. Anne, Rana Hegazi, Kylene Daily, Amal O. Amer, Mikhail A. Gavrilin, Arwa Abu Khweek, Asmaa Badr, Kaitlin Hamilton, Shady Estfanous, Brett Klamer, Kathrin Krause, and Xiaoli Zhang

Subjects
Methicillin-Resistant Staphylococcus aureus, Mitochondrial ROS, Staphylococcus aureus, Immunology, Antimycin A, Vacuole, Caspase-11, Mitochondrion, Biology, Biochemistry, Article, Microbiology, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, caspase‐11, Genetics, Animals, Molecular Biology, Cells, Cultured, 030304 developmental biology, Cytochalasin D, 0303 health sciences, Macrophages, Intracellular parasite, ROS, Articles, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Caspases, Initiator, Microbiology, Virology & Host Pathogen Interaction, ANT, Anti-Bacterial Agents, Mitochondria, 3. Good health, Mice, Inbred C57BL, chemistry, Vacuoles, Autophagy & Cell Death, Reactive Oxygen Species, 030217 neurology & neurosurgery, Intracellular
Abstract

Methicillin‐resistant Staphylococcus aureus (MRSA) is a growing health concern due to increasing resistance to antibiotics. As a facultative intracellular pathogen, MRSA is capable of persisting within professional phagocytes including macrophages. Here, we identify a role for CASP11 in facilitating MRSA survival within murine macrophages. We show that MRSA actively prevents the recruitment of mitochondria to the vicinity of the vacuoles they reside in to avoid intracellular demise. This process requires CASP11 since its deficiency allows increased association of MRSA‐containing vacuoles with mitochondria. The induction of mitochondrial superoxide by antimycin A (Ant A) improves MRSA eradication in casp11 −/− cells, where mitochondria remain in the vicinity of the bacterium. In WT macrophages, Ant A does not affect MRSA persistence. When mitochondrial dissociation is prevented by the actin depolymerizing agent cytochalasin D, Ant A effectively reduces MRSA numbers. Moreover, the absence of CASP11 leads to reduced cleavage of CASP1, IL‐1β, and CASP7, as well as to reduced production of CXCL1/KC. Our study provides a new role for CASP11 in promoting the persistence of Gram‐positive bacteria., Staphylococcus aureus exploits caspase‐11 to dissociate MRSA‐containing vacuoles from mitochondria. Caspase‐11 also promotes inflammasome activation and secretion of IL‐1α, IL‐1β, and CXCL1/KC in response to MRSA infection in macrophages.

Published
2019

44. Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages

Author

Amr E. Ahmed, Madelyn M. Gerber, Hany Khalil, Duaa Dakhlallah, Ian C. Davis, Amal O. Amer, Mia Tazi, Kathrin Krause, Estelle Cormet-Boyaka, Sheng-Wei Chang, Larry S. Schlesinger, Benjamin T. Kopp, Amy E. Lovett-Racke, Clay B. Marsh, and Kyle Caution

Subjects
0301 basic medicine, Cystic Fibrosis, Burkholderia cenocepacia, Regulator, Autophagy-Related Proteins, Cystic Fibrosis Transmembrane Conductance Regulator, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, microRNA, Gene expression, Autophagy, Animals, 3' Untranslated Regions, Lung, Molecular Biology, Cells, Cultured, biology, Macrophages, Homozygote, Antagomirs, Cell Biology, biology.organism_classification, Basic Research Paper, Cystic fibrosis transmembrane conductance regulator, Transmembrane protein, Cell biology, Mice, Inbred C57BL, MicroRNAs, 030104 developmental biology, Gene Expression Regulation, 030220 oncology & carcinogenesis, NIH 3T3 Cells, biology.protein
Abstract

Cystic fibrosis (CF) is a fatal, genetic disorder that critically affects the lungs and is directly caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR function. Macroautophagy/autophagy is a highly regulated biological process that provides energy during periods of stress and starvation. Autophagy clears pathogens and dysfunctional protein aggregates within macrophages. However, this process is impaired in CF patients and CF mice, as their macrophages exhibit limited autophagy activity. The study of microRNAs (Mirs), and other noncoding RNAs, continues to offer new therapeutic targets. The objective of this study was to elucidate the role of Mirs in dysregulated autophagy-related genes in CF macrophages, and then target them to restore this host-defense function and improve CFTR channel function. We identified the Mirc1/Mir17-92 cluster as a potential negative regulator of autophagy as CF macrophages exhibit decreased autophagy protein expression and increased cluster expression when compared to wild-type (WT) counterparts. The absence or reduced expression of the cluster increases autophagy protein expression, suggesting the canonical inverse relationship between Mirc1/Mir17-92 and autophagy gene expression. An in silico study for targets of Mirs that comprise the cluster suggested that the majority of the Mirs target autophagy mRNAs. Those targets were validated by luciferase assays. Notably, the ability of macrophages expressing mutant F508del CFTR to transport halide through their membranes is compromised and can be restored by downregulation of these inherently elevated Mirs, via restoration of autophagy. In vivo, downregulation of Mir17 and Mir20a partially restored autophagy expression and hence improved the clearance of Burkholderia cenocepacia. Thus, these data advance our understanding of mechanisms underlying the pathobiology of CF and provide a new therapeutic platform for restoring CFTR function and autophagy in patients with CF.

Published
2016

45. CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection

Author

Kaitlin Hamilton, Rana Hegazi, Asmaa Badr, Amal O. Amer, Luanne Hall-Stoodley, Kyle Caution, Mikhail A. Gavrilin, Stephanie Seveau, Khushbu Patel, Xiaoli Zhang, Kathrin Krause, and Abdulmuti Saleh

Subjects
0301 basic medicine, Burkholderia cenocepacia, Inflammasomes, Caspase-11, Legionella pneumophila, 03 medical and health sciences, Mice, Phagosomes, medicine, Autophagy, Escherichia coli, Animals, Molecular Biology, Cells, Cultured, Phagosome, Mice, Knockout, biology, Intracellular parasite, Macrophages, Autophagosomes, Inflammasome, Burkholderia Infections, Cell Biology, Bacterial Infections, biology.organism_classification, Actin cytoskeleton, Caspases, Initiator, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Caspases, medicine.drug
Abstract

CASP4/caspase-11-dependent inflammasome activation is important for the clearance of various Gram-negative bacteria entering the host cytosol. Additionally, CASP4 modulates the actin cytoskeleton to promote the maturation of phagosomes harboring intracellular pathogens such as Legionella pneumophila but not those enclosing nonpathogenic bacteria. Nevertheless, this non-inflammatory role of CASP4 regarding the trafficking of vacuolar bacteria remains poorly understood. Macroautophagy/autophagy, a catabolic process within eukaryotic cells, is also implicated in the elimination of intracellular pathogens such as Burkholderia cenocepacia. Here we show that CASP4-deficient macrophages exhibit a defect in autophagosome formation in response to B. cenocepacia infection. The absence of CASP4 causes an accumulation of the small GTPase RAB7, reduced colocalization of B. cenocepacia with LC3 and acidic compartments accompanied by increased bacterial replication in vitro and in vivo. Together, our data reveal a novel role of CASP4 in regulating autophagy in response to B. cenocepacia infection.

Published
2018

46. The psychoactive substance of cannabis Δ9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells

Author

Rachael E. Rayner, Wissam Osman, Xiaoli Zhang, Prosper N. Boyaka, Amal O. Amer, Mark E. Peeples, Jack Wellmerling, Sheng-Wei Chang, Sara Mertz, and Estelle Cormet-Boyaka

Subjects
0301 basic medicine, MAPK/ERK pathway, congenital, hereditary, and neonatal diseases and abnormalities, MAP Kinase Signaling System, medicine.medical_treatment, Biophysics, Cystic Fibrosis Transmembrane Conductance Regulator, Bronchi, Pharmacology, Biochemistry, 03 medical and health sciences, Downregulation and upregulation, mental disorders, medicine, Humans, Dronabinol, Molecular Biology, Cells, Cultured, Regulation of gene expression, Cannabis smoking, Lung, biology, Chemistry, organic chemicals, Epithelial Cells, respiratory system, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, ErbB Receptors, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, biology.protein, Hallucinogens, Homeostasis
Abstract

Background Marijuana consumption is on the rise in the US but the health benefits of cannabis smoking are controversial and the impact of cannabis components on lung homeostasis is not well-understood. Lung function requires a fine regulation of the ion channel CFTR, which is responsible for fluid homeostasis and mucocilliary clearance. The goal of this study was to assess the effect that exposure to Δ9-tetrahydrocannabinol (THC), the psychoactive substance present in marijuana, has on CFTR expression and function. Methods Cultures of human bronchial epithelial cell line 16HBE14o- and primary human airway epithelial cells were exposed to THC. The expression of CFTR protein was determined by immunoblotting and CFTR function was measured using Ussing chambers. We also used specific pharmacological inhibitors of EGFR and ERK to determine the role of this pathway in THC-induced regulation of CFTR. Results THC decreased CFTR protein expression in primary human bronchial epithelial cells. This decrease was associated with reduced CFTR-mediated short-circuit currents. THC also induced activation of the ERK MAPK pathway via activation of EGFR. Inhibition of EGFR or MEK/ERK prevented THC-induced down regulation of CFTR protein expression. Conclusions and general significance THC negatively regulates CFTR and this is mediated through the EGFR/ERK axis. This study provides the first evidence that THC present in marijuana reduces the expression and function of CFTR in airway epithelial cells.

Published
2018

47. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses

Author

Kenneth L. Brockman, Lauren O. Bakaletz, Amal O. Amer, Santiago Partida-Sanchez, Juan de Dios Ruiz-Rosado, Frank Robledo-Avila, Benjamin T. Kopp, and Karen McCoy

Subjects
0301 basic medicine, Male, Burkholderia cenocepacia, Adolescent, Cystic Fibrosis, Neutrophils, Immunology, Cystic Fibrosis Transmembrane Conductance Regulator, Inflammation, Cystic fibrosis, Article, Microbiology, 03 medical and health sciences, Mice, Immune system, medicine, Immunology and Allergy, Animals, Homeostasis, Humans, Calcium Signaling, Child, chemistry.chemical_classification, Mice, Knockout, Reactive oxygen species, NADPH oxidase, biology, Immunity, NADPH Oxidases, Burkholderia Infections, Neutrophil extracellular traps, Pneumonia, biology.organism_classification, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Neutrophil Infiltration, Mutation, biology.protein, Calcium, Female, Calcium Channels, medicine.symptom, Reactive Oxygen Species
Abstract

Cystic fibrosis (CF), one of the most common human genetic diseases worldwide, is caused by a defect in the CF transmembrane conductance regulator (CFTR). Patients with CF are highly susceptible to infections caused by opportunistic pathogens (including Burkholderia cenocepacia), which induce excessive lung inflammation and lead to the eventual loss of pulmonary function. Abundant neutrophil recruitment into the lung is a key characteristic of bacterial infections in CF patients. In response to infection, inflammatory neutrophils release reactive oxygen species and toxic proteins, leading to aggravated lung tissue damage in patients with CF. The present study shows a defect in reactive oxygen species production by mouse Cftr−/−, human F508del-CFTR, and CF neutrophils; this results in reduced antimicrobial activity against B. cenocepacia. Furthermore, dysregulated Ca2+ homeostasis led to increased intracellular concentrations of Ca2+ that correlated with significantly diminished NADPH oxidase response and impaired secretion of neutrophil extracellular traps in human CF neutrophils. Functionally deficient human CF neutrophils recovered their antimicrobial killing capacity following treatment with pharmacological inhibitors of Ca2+ channels and CFTR channel potentiators. Our findings suggest that regulation of neutrophil Ca2+ homeostasis (via CFTR potentiation or by the regulation of Ca2+ channels) can be used as a new therapeutic approach for reestablishing immune function in patients with CF.

Published
2018

48. TGF-β-induced IL-6 prevents development of acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice

Author

Mia Tazi, Ian C. Davis, Parker S. Woods, Nicholas M. Chesarino, and Amal O. Amer

Subjects
Pulmonary and Respiratory Medicine, Chemokine, Mice, 129 Strain, animal structures, Physiology, Acute Lung Injury, Biology, Lung injury, medicine.disease_cause, Orthomyxoviridae Infections, Transforming Growth Factor beta, Physiology (medical), Macrophages, Alveolar, medicine, Influenza A virus, Animals, Mice, Inbred CFTR, Interleukin 6, Sequence Deletion, Lung, medicine.diagnostic_test, Interleukin-6, cystic fibrosis transmembrane conductance regulator, transforming growth factor-β, Cell Biology, respiratory system, Pulmonary edema, medicine.disease, Immunity, Innate, Cystic fibrosis transmembrane conductance regulator, respiratory tract diseases, 3. Good health, Mice, Inbred C57BL, Bronchoalveolar lavage, medicine.anatomical_structure, Immunology, Call for Papers, biology.protein, influenza, Bronchoalveolar Lavage Fluid
Abstract

As the eighth leading cause of annual mortality in the USA, influenza A viruses are a major public health concern. In 20% of patients, severe influenza progresses to acute lung injury (ALI). However, pathophysiological mechanisms underlying ALI development are poorly defined. We reported that, unlike wild-type (WT) C57BL/6 controls, influenza A virus-infected mice that are heterozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (HETs) did not develop ALI. This effect was associated with higher IL-6 and alveolar macrophages (AMs) at 6 days postinfection (d.p.i.) in HET bronchoalveolar lavage fluid (BALF). In the present study, we found that HET AMs were an important source of IL-6 at 6 d.p.i. Infection also induced TGF-β production by HET but not WT mice at 2 d.p.i. TGF-β neutralization at 2 d.p.i. (TGF-N) significantly reduced BALF IL-6 in HETs at 6 d.p.i. Neither TGF-N nor IL-6 neutralization at 4 d.p.i. (IL-6-N) altered postinfection weight loss or viral replication in either mouse strain. However, both treatments increased influenza A virus-induced hypoxemia, pulmonary edema, and lung dysfunction in HETs to WT levels at 6 d.p.i. TGF-N and IL-6-N did not affect BALF AM and neutrophil numbers but attenuated the CXCL-1/keratinocyte chemokine response in both strains and reduced IFN-γ production in WT mice. Finally, bone marrow transfer experiments showed that HET stromal and myeloid cells are both required for protection from ALI in HETs. These findings indicate that TGF-β-dependent production of IL-6 by AMs later in infection prevents ALI development in influenza A virus-infected HET mice.

Published
2015

49. The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?

Author

Estelle Cormet-Boyaka, Dalia H. A. Abdelaziz, Amal O. Amer, and Hany Khalil

Subjects
Autophagosome, Innate immune system, Inflammasomes, Intracellular parasite, Immunology, Autophagy, Neurodegenerative Diseases, Inflammasome, Disease, Vacuole, Biology, Infections, Article, Immunity, Innate, Cell biology, Multiprotein Complexes, Phagosomes, medicine, Animals, Humans, Immunology and Allergy, Phagosome, medicine.drug
Abstract

Autophagy is originally described as the main catabolic pathway responsible for maintaining intracellular nutritional homeosta-sis that involves the formation of a unique vacuole, the autophago-some, and the interaction with the endosome-lysosome pathways. This conserved machinery plays a key role in immune-protection against different invaders, including pathogenic bacteria, intracellular parasites, and some viruses like herpes simplex and hepatitis C virus. Importantly, autophagy is linked to a number of human diseases and disorders including neurodegenerative disease, Crohn’s disease, type II diabetes, tumorigenesis, cardiomyopathy, and fatty liver disease. On the other hand, inflammasomes are multiprotein platforms stimulated upon several environmental conditions and microbial infection. Once assembled, the inflammasomes mediate the maturation of pro-inflammatory cytokines and promote phagosome-lysosome fusion to sustain an innate immune response. The intersections between autophagy and inflammasome have been observed in various diseases and microbial infections. This review highlights the molecular aspects involved in autophagy and inflammasome interactions during different medical conditions and microbial infections.

Published
2015

50. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Author

Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M. Adams, Peter D. Adams, Khosrow Adeli, Peter J. Adhihetty, Sharon G. Adler, Galila Agam, Rajesh Agarwal, Manish K. Aghi, Maria Agnello, Patrizia Agostinis, Patricia V. Aguilar, Julio Aguirre Ghiso, Edoardo M. Airoldi, Slimane Ait Si Ali, Takahiko Akematsu, Emmanuel T. Akporiaye, Mohamed Al Rubeai, Guillermo M. Albaiceta, Chris Albanese, Diego Albani, Matthew L. Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte Beceril, Emad S. Alnemri, Covadonga Alonso, Nihal Altan Bonnet, Dario C. Altieri, Silvia Alvarez, Lydia Alvarez Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O. Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A. Anania, Stig U. Andersen, Usha P. Andley, Catherine K. Andreadi, Nathalie Andrieu Abadie, Alberto Anel, David K. Ann, Shailendra Anoopkumar Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R. Ariosa, Jane L. Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S. Atherton, Julie D. Atkin, Laura D. Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M. Backer, Dong Hun Bae, Jae sung Bae, Ok Nam Bae, Soo Han Bae, Eric H. Baehrecke, Seung Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska Zadworna, Hua Bai, Jie Bai, Xue Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D. Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C. Bassham, Maria Teresa Bassi, Robert C. Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L. Baumgarner, K. Ulrich Bayer, Rupert Beale, Jean François Beaulieu, George R. Beck Jr, Christoph Becker, J. David Beckham, Pierre André Bédard, Patrick J. Bednarski, Thomas J. Begley, Christian Behl, Christian Behrends, Georg MN Behrens, Kevin E. Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S. Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K. Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W. Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A. Blanco, Heidi Kiil Blomhoff, Emilio Boada Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze Battaglia, Lawrence H. Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M. Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie Josée Boucher, Michael E. Boulton, Sebastien G. Bouret, Patricia Boya, Michaël Boyer Guittaut, Peter V. Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H. Braus, José M. Bravo San Pedro, Lisa A. Brennan, Emery H. Bresnick, Patrick Brest, Dave Bridges, MarieAgnès Bringer, Marisa Brini, Glauber C. Brito, Bertha Brodin, Paul S. Brookes, Eric J. Brown, Karen Brown, Hal E. Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H. Brumell, Nicola Brunetti Pierri, Robert J. Bryson Richardson, Shilpa Buch, Alastair M. Buchan, Hikmet Budak, Dmitry V. Bulavin, Scott J. Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E. Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R. Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, Lavinia Cantoni, Lizhi Cao, Allan B. Caplan, Michele Caraglia, Claudio Cardinali, Sandra Morais Cardoso, Jennifer S. Carew, Laura A. Carleton, Cathleen R. Carlin, Silvia Carloni, Sven R. Carlsson, Didac Carmona Gutierrez, Leticia AM Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casas, Josefina Casas, Giuliana Cassinelli, Perrine Castets, Susana Castro Obregon, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I. Cederbaum, Valentín Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, CETRULLO, SILVIA, Hassan Chaachouay, Han Jung Chae, Andrei S. Chagin, Chee Yin Chai, Gopal Chakrabarti, Georgios Chamilos, Edmond YW Chan, Matthew TV Chan, Dhyan Chandra, Pallavi Chandra, Chih Peng Chang, Raymond Chuen Chung Chang, Ta Yuan Chang, John C. Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E. Cheetham, Rajkumar Cheluvappa, Chun Jung Chen, Gang Chen, Guang Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W. Chen, Jian Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang Der Chen, Si Chen, Steve S. L. Chen, Wei Chen, Wei Jung Chen, Wen Qiang Chen, Wenli Chen, Xiangmei Chen, Yau Hung Chen, Ye Guang Chen, Yin Chen, Yingyu Chen, Yongshun Chen, Yu Jen Chen, Yue Qin Chen, Yujie Chen, Zhen Chen, Zhong Chen, Alan Cheng, Christopher HK Cheng, Hua Cheng, Heesun Cheong, Sara Cherry, Jason Chesney, Chun Hei Antonio Cheung, Eric Chevet, Hsiang Cheng Chi, Sung Gil Chi, Fulvio Chiacchiera, Hui Ling Chiang, Roberto Chiarelli, Mario Chiariello, Marcello Chieppa, Lih Shen Chin, Mario Chiong, Gigi NC Chiu, Dong Hyung Cho, Ssang Goo Cho, William C. Cho, Yong Yeon Cho, Young Seok Cho, Augustine MK Choi, Eui Ju Choi, Eun Kyoung Choi, Jayoung Choi, Mary E. Choi, Seung Il Choi, Tsui Fen Chou, Salem Chouaib, Divaker Choubey, Vinay Choubey, Kuan Chih Chow, Kamal Chowdhury, Charleen T. Chu, Tsung Hsien Chuang, Taehoon Chun, Hyewon Chung, Taijoon Chung, Yuen Li Chung, Yong Joon Chwae, Valentina Cianfanelli, Roberto Ciarcia, Iwona A. Ciechomska, Maria Rosa Ciriolo, Mara Cirone, Sofie Claerhout, Michael J. Clague, Joan Clària, Peter GH Clarke, Robert Clarke, Emilio Clementi, Cédric Cleyrat, Miriam Cnop, Eliana M. Coccia, Tiziana Cocco, Patrice Codogno, Jörn Coers, Ezra EW Cohen, David Colecchia, Luisa Coletto, Núria S. Coll, Emma Colucci Guyon, Sergio Comincini, Maria Condello, Katherine L. Cook, Graham H. Coombs, Cynthia D. Cooper, J. Mark Cooper, Isabelle Coppens, Maria Tiziana Corasaniti, Marco Corazzari, Ramon Corbalan, Elisabeth Corcelle Termeau, Mario D. Cordero, Cristina Corral Ramos, Olga Corti, Andrea Cossarizza, Paola Costelli, Safia Costes, Susan L. Cotman, Ana Coto Montes, Sandra Cottet, Eduardo Couve, Lori R. Covey, L. Ashley Cowart, Jeffery S. Cox, Fraser P. Coxon, Carolyn B. Coyne, Mark S. Cragg, Rolf J. Craven, Tiziana Crepaldi, Jose L. Crespo, Alfredo Criollo, Valeria Crippa, Maria Teresa Cruz, Ana Maria Cuervo, Jose M. Cuezva, Taixing Cui, Pedro R. Cutillas, Mark J. Czaja, Maria F. Czyzyk Krzeska, Ruben K. Dagda, Uta Dahmen, Chunsun Dai, Wenjie Dai, Yun Dai, Kevin N. Dalby, Luisa Dalla Valle, Guillaume Dalmasso, Marcello D'Amelio, Markus Damme, Arlette Darfeuille Michaud, Catherine Dargemont, Victor M. Darley Usmar, Srinivasan Dasarathy, Biplab Dasgupta, Srikanta Dash, Crispin R. Dass, Hazel Marie Davey, Lester M. Davids, David Dávila, Roger J. Davis, Ted M. Dawson, Valina L. Dawson, Paula Daza, Jackie de Belleroche, Paul de Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, José de la Fuente, Luisa De Martino, Antonella De Matteis, Guido RY De Meyer, Angelo De Milito, Mauro De Santi, Wanderley de Souza, Vincenzo De Tata, Daniela De Zio, Jayanta Debnath, Reinhard Dechant, Jean Paul Decuypere, Shane Deegan, Benjamin Dehay, Barbara Del Bello, Dominic P. Del Re, Régis Delage Mourroux, Lea MD Delbridge, Louise Deldicque, Elizabeth Delorme Axford, Yizhen Deng, Joern Dengjel, Melanie Denizot, Paul Dent, Channing J. Der, Vojo Deretic, Benoît Derrien, Eric Deutsch, Timothy P. Devarenne, Rodney J. Devenish, Sabrina Di Bartolomeo, Nicola Di Daniele, Fabio Di Domenico, Alessia Di Nardo, Simone Di Paola, Antonio Di Pietro, Livia Di Renzo, Aaron DiAntonio, Guillermo Díaz Araya, Ines Díaz Laviada, Maria T. Diaz Meco, Javier Diaz Nido, Chad A. Dickey, Robert C. Dickson, Marc Diederich, Paul Digard, Ivan Dikic, Savithrama P. Dinesh Kumar, Chan Ding, Wen Xing Ding, Zufeng Ding, Luciana Dini, Jörg HW Distler, Abhinav Diwan, Mojgan Djavaheri Mergny, Kostyantyn Dmytruk, Renwick CJ Dobson, Volker Doetsch, Karol Dokladny, Svetlana Dokudovskaya, Massimo Donadelli, X. Charlie Dong, Xiaonan Dong, Zheng Dong, Terrence M. Donohue Jr, Kelly S. Doran, Gabriella D'Orazi, Gerald W. Dorn II, Victor Dosenko, Sami Dridi, Liat Drucker, Jie Du, Li Lin Du, Lihuan Du, André du Toit, Priyamvada Dua, Lei Duan, Pu Duann, Vikash Kumar Dubey, Michael R. Duchen, Michel A. Duchosal, Helene Duez, Isabelle Dugail, Verónica I. Dumit, Mara C. Duncan, Elaine A. Dunlop, William A. Dunn Jr, Nicolas Dupont, Luc Dupuis, Raúl V. Durán, Thomas M. Durcan, Stéphane Duvezin Caubet, Umamaheswar Duvvuri, Vinay Eapen, Darius Ebrahimi Fakhari, Arnaud Echard, Leopold Eckhart, Charles L. Edelstein, Aimee L. Edinger, Ludwig Eichinger, Tobias Eisenberg, Avital Eisenberg Lerner, N. Tony Eissa, Wafik S. El Deiry, Victoria El Khoury, Zvulun Elazar, Hagit Eldar Finkelman, Chris JH Elliott, Enzo Emanuele, Urban Emmenegger, Nikolai Engedal, Anna Mart Engelbrecht, Simone Engelender, Jorrit M. Enserink, Ralf Erdmann, Jekaterina Erenpreisa, Rajaraman Eri, Jason L. Eriksen, Andreja Erman, Ricardo Escalante, Eeva Liisa Eskelinen, Lucile Espert, Lorena Esteban Martínez, Thomas J. Evans, Mario Fabri, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Nils J. Færgeman, Alberto Faggioni, W. Douglas Fairlie, Chunhai Fan, Daping Fan, Jie Fan, Shengyun Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farkas, Mathias Faure, Francois B. Favier, Howard Fearnhead, Massimo Federici, Erkang Fei, Tania C. Felizardo, Hua Feng, Yibin Feng, Yuchen Feng, Thomas A. Ferguson, Álvaro F. Fernández, Maite G. Fernandez Barrena, Jose C. Fernandez Checa, Arsenio Fernández López, Martin E. Fernandez Zapico, Olivier Feron, Elisabetta Ferraro, Carmen Veríssima Ferreira Halder, Laszlo Fesus, Ralph Feuer, Fabienne C. Fiesel, Eduardo C. Filippi Chiela, Giuseppe Filomeni, Gian Maria Fimia, John H. Fingert, Steven Finkbeiner, Toren Finkel, Filomena Fiorito, Paul B. Fisher, Marc Flajolet, FLAMIGNI, FLAVIO, Oliver Florey, Salvatore Florio, R. Andres Floto, Marco Folini, Carlo Follo, Edward A. Fon, Francesco Fornai, Franco Fortunato, Alessandro Fraldi, Rodrigo Franco, Arnaud Francois, Aurélie François, Lisa B. Frankel, Iain DC Fraser, Norbert Frey, Damien G. Freyssenet, Christian Frezza, Scott L. Friedman, Daniel E. Frigo, Dongxu Fu, José M. Fuentes, Juan Fueyo, Yoshio Fujitani, Yuuki Fujiwara, Mikihiro Fujiya, Mitsunori Fukuda, Simone Fulda, Carmela Fusco, Bozena Gabryel, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Sehamuddin Galadari, Gad Galili, Inmaculada Galindo, Maria F. Galindo, Giovanna Galliciotti, Lorenzo Galluzzi, Luca Galluzzi, Vincent Galy, Noor Gammoh, Sam Gandy, Anand K. Ganesan, Swamynathan Ganesan, Ian G. Ganley, Monique Gannagé, Fen Biao Gao, Feng Gao, Jian Xin Gao, Lorena García Nannig, Eleonora García Véscovi, Marina Garcia Macía, Carmen Garcia Ruiz, Abhishek D. Garg, Pramod Kumar Garg, Ricardo Gargini, Nils Christian Gassen, Damián Gatica, Evelina Gatti, Julie Gavard, Evripidis Gavathiotis, Liang Ge, Pengfei Ge, Shengfang Ge, Po Wu Gean, Vania Gelmetti, Armando A. Genazzani, Jiefei Geng, Pascal Genschik, Lisa Gerner, Jason E. Gestwicki, David A. Gewirtz, Saeid Ghavami, Eric Ghigo, Debabrata Ghosh, Anna Maria Giammarioli, Francesca Giampieri, Claudia Giampietri, Alexandra Giatromanolaki, Derrick J. Gibbings, Lara Gibellini, Spencer B. Gibson, Vanessa Ginet, Antonio Giordano, Flaviano Giorgini, Elisa Giovannetti, Stephen E. Girardin, Suzana Gispert, Sandy Giuliano, Candece L. Gladson, Alvaro Glavic, Martin Gleave, Nelly Godefroy, Robert M. Gogal Jr, Kuppan Gokulan, Gustavo H. Goldman, Delia Goletti, Michael S. Goligorsky, Aldrin V. Gomes, Ligia C. Gomes, Hernando Gomez, Candelaria Gomez Manzano, Rubén Gómez Sánchez, Dawit AP Gonçalves, Ebru Goncu, Qingqiu Gong, Céline Gongora, Carlos B. Gonzalez, Pedro Gonzalez Alegre, Pilar Gonzalez Cabo, Rosa Ana González Polo, Ing Swie Goping, Carlos Gorbea, Nikolai V. Gorbunov, Daphne R. Goring, Adrienne M. Gorman, Sharon M. Gorski, Sandro Goruppi, Shino Goto Yamada, Cecilia Gotor, Roberta A. Gottlieb, Illana Gozes, Devrim Gozuacik, Yacine Graba, Martin Graef, Giovanna E. Granato, Gary Dean Grant, Steven Grant, Giovanni Luca Gravina, Douglas R. Green, Alexander Greenhough, Michael T. Greenwood, Benedetto Grimaldi, Frédéric Gros, Charles Grose, Jean Francois Groulx, Florian Gruber, Paolo Grumati, Tilman Grune, Jun Lin Guan, Kun Liang Guan, Barbara Guerra, Carlos Guillen, Kailash Gulshan, Jan Gunst, Chuanyong Guo, Lei Guo, Ming Guo, Wenjie Guo, Xu Guang Guo, Andrea A. Gust, Åsa B. Gustafsson, Elaine Gutierrez, Maximiliano G. Gutierrez, Ho Shin Gwak, Albert Haas, James E. Haber, Shinji Hadano, Monica Hagedorn, David R. Hahn, Andrew J. Halayko, Anne Hamacher Brady, Kozo Hamada, Ahmed Hamai, Andrea Hamann, Maho Hamasaki, Isabelle Hamer, Qutayba Hamid, Ester M. Hammond, Feng Han, Weidong Han, James T. Handa, John A. Hanover, Malene Hansen, Masaru Harada, Ljubica Harhaji Trajkovic, J. Wade Harper, Abdel Halim Harrath, Adrian L. Harris, James Harris, Udo Hasler, Peter Hasselblatt, Kazuhisa Hasui, Robert G. Hawley, Teresa S. Hawley, Congcong He, Cynthia Y. He, Fengtian He, Gu He, Rong Rong He, Xian Hui He, You Wen He, Yu Ying He, Joan K. Heath, Marie Josée Hébert, Robert A. Heinzen, Gudmundur Vignir Helgason, Michael Hensel, Elizabeth P. Henske, Chengtao Her, Paul K. Herman, Agustín Hernández, Carlos Hernandez, Sonia Hernández Tiedra, Claudio Hetz, P. Robin Hiesinger, Katsumi Higaki, Sabine Hilfiker, Bradford G. Hill, Joseph A. Hill, William D. Hill, Keisuke Hino, Daniel Hofius, Paul Hofman, Günter U. Höglinger, Jörg Höhfeld, Marina K. Holz, Yonggeun Hong, David A. Hood, Jeroen JM Hoozemans, Thorsten Hoppe, Chin Hsu, Chin Yuan Hsu, Li Chung Hsu, Dong Hu, Guochang Hu, Hong Ming Hu, Hongbo Hu, Ming Chang Hu, Yu Chen Hu, Zhuo Wei Hu, Fang Hua, Ya Hua, Canhua Huang, Huey Lan Huang, Kuo How Huang, Kuo Yang Huang, Shile Huang, Shiqian Huang, Wei Pang Huang, Yi Ran Huang, Yong Huang, Yunfei Huang, Tobias B. Huber, Patricia Huebbe, Won Ki Huh, Juha J. Hulmi, Gang Min Hur, James H. Hurley, Zvenyslava Husak, Sabah NA Hussain, Salik Hussain, Jung Jin Hwang, Seungmin Hwang, Thomas IS Hwang, Atsuhiro Ichihara, Yuzuru Imai, Carol Imbriano, Megumi Inomata, Takeshi Into, Valentina Iovane, Juan L. Iovanna, Renato V. Iozzo, Nancy Y. Ip, Javier E. Irazoqui, Pablo Iribarren, Yoshitaka Isaka, Aleksandra J. Isakovic, Harry Ischiropoulos, Jeffrey S. Isenberg, Mohammad Ishaq, Hiroyuki Ishida, Isao Ishii, Jane E. Ishmael, Ciro Isidoro, Ken ichi Isobe, Erika Isono, Shohreh Issazadeh Navikas, Koji Itahana, Eisuke Itakura, Andrei I. Ivanov, Anand Krishnan V. Iyer, José M. Izquierdo, Yotaro Izumi, Valentina Izzo, Marja Jäättelä, Nadia Jaber, Daniel John Jackson, William T. Jackson, Tony George Jacob, Thomas S. Jacques, Chinnaswamy Jagannath, Ashish Jain, Nihar Ranjan Jana, Byoung Kuk Jang, Alkesh Jani, Bassam Janji, Paulo Roberto Jannig, Patric J. Jansson, Steve Jean, Marina Jendrach, Ju Hong Jeon, Niels Jessen, Eui Bae Jeung, Kailiang Jia, Lijun Jia, Hong Jiang, Hongchi Jiang, Liwen Jiang, Teng Jiang, Xiaoyan Jiang, Xuejun Jiang, Ying Jiang, Yongjun Jiang, Alberto Jiménez, Cheng Jin, Hongchuan Jin, Lei Jin, Meiyan Jin, Shengkan Jin, Umesh Kumar Jinwal, Eun Kyeong Jo, Terje Johansen, Daniel E. Johnson, Gail VW Johnson, James D. Johnson, Eric Jonasch, Chris Jones, Leo AB Joosten, Joaquin Jordan, Anna Maria Joseph, Bertrand Joseph, Annie M. Joubert, Dianwen Ju, Jingfang Ju, Hsueh Fen Juan, Katrin Juenemann, Gábor Juhász, Hye Seung Jung, Jae U. Jung, Yong Keun Jung, Heinz Jungbluth, Matthew J. Justice, Barry Jutten, Nadeem O. Kaakoush, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Bertrand Kaeffer, Katarina Kågedal, Alon Kahana, Shingo Kajimura, Or Kakhlon, Manjula Kalia, Dhan V. Kalvakolanu, Yoshiaki Kamada, Konstantinos Kambas, Vitaliy O. Kaminskyy, Harm H. Kampinga, Mustapha Kandouz, Chanhee Kang, Rui Kang, Tae Cheon Kang, Tomotake Kanki, Thirumala Devi Kanneganti, Haruo Kanno, Anumantha G. Kanthasamy, Marc Kantorow, Maria Kaparakis Liaskos, Orsolya Kapuy, Vassiliki Karantza, Md Razaul Karim, Parimal Karmakar, Arthur Kaser, Susmita Kaushik, Thomas Kawula, A. Murat Kaynar, Po Yuan Ke, Zun Ji Ke, John H. Kehrl, Kate E. Keller, Jongsook Kim Kemper, Anne K. Kenworthy, Oliver Kepp, Andreas Kern, Santosh Kesari, David Kessel, Robin Ketteler, Isis do Carmo Kettelhut, Bilon Khambu, Muzamil Majid Khan, Vinoth KM Khandelwal, Sangeeta Khare, Juliann G. Kiang, Amy A. Kiger, Akio Kihara, Arianna L. Kim, Cheol Hyeon Kim, Deok Ryong Kim, Do Hyung Kim, Eung Kweon Kim, Hye Young Kim, Hyung Ryong Kim, Jae Sung Kim, Jeong Hun Kim, Jin Cheon Kim, Jin Hyoung Kim, Kwang Woon Kim, Michael D. Kim, Moon Moo Kim, Peter K. Kim, Seong Who Kim, Soo Youl Kim, Yong Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C. Kimmelman, Tomonori Kimura, Jason S. King, Karla Kirkegaard, Vladimir Kirkin, Lorrie A. Kirshenbaum, Shuji Kishi, Yasuo Kitajima, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Rudolf A. Kley, Walter T. Klimecki, Michael Klinkenberg, Jochen Klucken, Helene Knævelsrud, Erwin Knecht, Laura Knuppertz, Jiunn Liang Ko, Satoru Kobayashi, Jan C. Koch, Christelle Koechlin Ramonatxo, Ulrich Koenig, Young Ho Koh, Katja Köhler, Sepp D. Kohlwein, Masato Koike, Masaaki Komatsu, Eiki Kominami, Dexin Kong, Hee Jeong Kong, Eumorphia G. Konstantakou, Benjamin T. Kopp, Tamas Korcsmaros, Laura Korhonen, Viktor I. Korolchuk, Nadya V. Koshkina, Yanjun Kou, Michael I. Koukourakis, Constantinos Koumenis, Attila L. Kovács, Tibor Kovács, Werner J. Kovacs, Daisuke Koya, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Tamara Kravic Stevovic, Wilhelm Krek, Carole Kretz Remy, Roswitha Krick, Malathi Krishnamurthy, Janos Kriston Vizi, Guido Kroemer, Michael C. Kruer, Rejko Kruger, Nicholas T. Ktistakis, Kazuyuki Kuchitsu, Christian Kuhn, Addanki Pratap Kumar, Anuj Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Rakesh Kumar, Sharad Kumar, Mondira Kundu, Hsing Jien Kung, Atsushi Kuno, Sheng Han Kuo, Jeff Kuret, Tino Kurz, Terry Kwok, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert R. La Spada, Frank Lafont, Tim Lahm, Aparna Lakkaraju, Truong Lam, Trond Lamark, Steve Lancel, Terry H. Landowski, Darius JR Lane, Jon D. Lane, Cinzia Lanzi, Pierre Lapaquette, Louis R. Lapierre, Jocelyn Laporte, Johanna Laukkarinen, Gordon W. Laurie, Sergio Lavandero, Lena Lavie, Matthew J. LaVoie, Betty Yuen Kwan Law, Helen Ka wai Law, Kelsey B. Law, Robert Layfield, Pedro A. Lazo, Laurent Le Cam, Karine G. Le Roch, Hervé Le Stunff, Vijittra Leardkamolkarn, Marc Lecuit, Byung Hoon Lee, Che Hsin Lee, Erinna F. Lee, Gyun Min Lee, He Jin Lee, Hsinyu Lee, Jae Keun Lee, Jongdae Lee, Juhyun Lee, Jun Hee Lee, Michael Lee, Myung Shik Lee, Patty J. Lee, Sam W. Lee, Seung Jae Lee, Shiow Ju Lee, Stella Y. Lee, Sug Hyung Lee, Sung Sik Lee, Sung Joon Lee, Sunhee Lee, Ying Ray Lee, Yong J. Lee, Young H. Lee, Christiaan Leeuwenburgh, Sylvain Lefort, Renaud Legouis, Jinzhi Lei, Qun Ying Lei, David A. Leib, Gil Leibowitz, Istvan Lekli, Stéphane D. Lemaire, John J. Lemasters, Marius K. Lemberg, Antoinette Lemoine, Shuilong Leng, Guido Lenz, Paola Lenzi, Lilach O. Lerman, Daniele Lettieri Barbato, Julia I. Ju Leu, Hing Y. Leung, Beth Levine, Patrick A. Lewis, Frank Lezoualc'h, Chi Li, Faqiang Li, Feng Jun Li, Jun Li, Ke Li, Lian Li, Min Li, Qiang Li, Rui Li, Sheng Li, Wei Li, Xiaotao Li, Yumin Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Yulin Liao, Joana Liberal, Pawel P. Liberski, Pearl Lie, Andrew P. Lieberman, Hyunjung Jade Lim, Kah Leong Lim, Kyu Lim, Raquel T. Lima, Chang Shen Lin, Chiou Feng Lin, Fang Lin, Fangming Lin, Fu Cheng Lin, Kui Lin, Kwang Huei Lin, Pei Hui Lin, Tianwei Lin, Wan Wan Lin, Yee Shin Lin, Yong Lin, Rafael Linden, Dan Lindholm, Lisa M. Lindqvist, Paul Lingor, Andreas Linkermann, Lance A. Liotta, Marta M. Lipinski, Vitor A. Lira, Michael P. Lisanti, Paloma B. Liton, Bo Liu, Chong Liu, Chun Feng Liu, Fei Liu, Hung Jen Liu, Jianxun Liu, Jing Jing Liu, Jing Lan Liu, Ke Liu, Leyuan Liu, Liang Liu, Quentin Liu, Rong Yu Liu, Shiming Liu, Shuwen Liu, Wei Liu, Xian De Liu, Xiangguo Liu, Xiao Hong Liu, Xinfeng Liu, Xu Liu, Xueqin Liu, Yang Liu, Yule Liu, Zexian Liu, Zhe Liu, Juan P. Liuzzi, Gérard Lizard, Mila Ljujic, Irfan J. Lodhi, Susan E. Logue, Bal L. Lokeshwar, Yun Chau Long, Sagar Lonial, Benjamin Loos, Carlos López Otín, Cristina López Vicario, Mar Lorente, Philip L. Lorenzi, Péter Lõrincz, Marek Los, Michael T. Lotze, Penny E. Lovat, Binfeng Lu, Bo Lu, Jiahong Lu, Qing Lu, She Min Lu, Shuyan Lu, Yingying Lu, Frédéric Luciano, Shirley Luckhart, John Milton Lucocq, Paula Ludovico, Aurelia Lugea, Nicholas W. Lukacs, Julian J. Lum, Anders H. Lund, Honglin Luo, Jia Luo, Shouqing Luo, Claudio Luparello, Timothy Lyons, Jianjie Ma, Yi Ma, Yong Ma, Zhenyi Ma, Juliano Machado, Glaucia M. Machado Santelli, Fernando Macian, Gustavo C. MacIntosh, Jeffrey P. MacKeigan, Kay F. Macleod, John D. MacMicking, Lee Ann MacMillan Crow, Frank Madeo, Muniswamy Madesh, Julio Madrigal Matute, Akiko Maeda, Tatsuya Maeda, Gustavo Maegawa, Emilia Maellaro, Hannelore Maes, Marta Magariños, Kenneth Maiese, Tapas K. Maiti, Luigi Maiuri, Maria Chiara Maiuri, Carl G. Maki, Roland Malli, Walter Malorni, Alina Maloyan, Fathia Mami Chouaib, Na Man, Joseph D. Mancias, Eva Maria Mandelkow, Michael A. Mandell, Angelo A. Manfredi, Serge N. Manié, Claudia Manzoni, Kai Mao, Zixu Mao, Zong Wan Mao, Philippe Marambaud, Anna Maria Marconi, Zvonimir Marelja, Gabriella Marfe, Marta Margeta, Eva Margittai, Muriel Mari, Francesca V. Mariani, Concepcio Marin, Sara Marinelli, Guillermo Mariño, Ivanka Markovic, Rebecca Marquez, MARTELLI, ALBERTO MARIA, Sascha Martens, Katie R. Martin, Seamus J. Martin, Shaun Martin, Miguel A. Martin Acebes, Paloma Martín Sanz, Camille Martinand Mari, Wim Martinet, Jennifer Martinez, Nuria Martinez Lopez, Ubaldo Martinez Outschoorn, Moisés Martínez Velázquez, Marta Martinez Vicente, Waleska Kerllen Martins, Hirosato Mashima, James A. Mastrianni, Giuseppe Matarese, Paola Matarrese, Roberto Mateo, Satoaki Matoba, Naomichi Matsumoto, Takehiko Matsushita, Akira Matsuura, Takeshi Matsuzawa, Mark P. Mattson, Soledad Matus, Norma Maugeri, Caroline Mauvezin, Andreas Mayer, Dusica Maysinger, Guillermo D. Mazzolini, Mary Kate McBrayer, Kimberly McCall, Craig McCormick, Gerald M. McInerney, Skye C. McIver, Sharon McKenna, John J. McMahon, Iain A. McNeish, Fatima Mechta Grigoriou, Jan Paul Medema, Diego L. Medina, Klara Megyeri, Maryam Mehrpour, Jawahar L. Mehta, Yide Mei, Ute Christiane Meier, Alfred J. Meijer, Alicia Meléndez, Gerry Melino, Sonia Melino, Edesio Jose Tenorio de Melo, Maria A. Mena, Marc D. Meneghini, Javier A. Menendez, Regina Menezes, Liesu Meng, Ling hua Meng, Songshu Meng, Rossella Menghini, A. Sue Menko, Rubem FS Menna Barreto, Manoj B. Menon, Marco A. Meraz Ríos, Giuseppe Merla, Luciano Merlini, Angelica M. Merlot, Andreas Meryk, Stefania Meschini, Joel N. Meyer, Man tian Mi, Chao Yu Miao, Lucia Micale, Simon Michaeli, Carine Michiels, FRANCO MIGLIACCIO, ANNA RITA, Anastasia Susie Mihailidou, Dalibor Mijaljica, Katsuhiko Mikoshiba, Enrico Milan, Leonor Miller Fleming, Gordon B. Mills, Ian G. Mills, Georgia Minakaki, Berge A. Minassian, Xiu Fen Ming, Farida Minibayeva, Elena A. Minina, Justine D. Mintern, Saverio Minucci, Antonio Miranda Vizuete, Claire H. Mitchell, Shigeki Miyamoto, Keisuke Miyazawa, Noboru Mizushima, Katarzyna Mnich, Baharia Mograbi, Simin Mohseni, Luis Ferreira Moita, Marco Molinari, Maurizio Molinari, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Marco Mongillo, Martha M. Monick, Serena Montagnaro, Craig Montell, Darren J. Moore, Michael N. Moore, Rodrigo Mora Rodriguez, Paula I. Moreira, Etienne Morel, Maria Beatrice Morelli, Sandra Moreno, Michael J. Morgan, Arnaud Moris, Yuji Moriyasu, Janna L. Morrison, Lynda A. Morrison, Eugenia Morselli, Jorge Moscat, Pope L. Moseley, Serge Mostowy, Elisa Motori, Denis Mottet, Jeremy C. Mottram, Charbel E. H. Moussa, Vassiliki E. Mpakou, Hasan Mukhtar, Jean M. Mulcahy Levy, Sylviane Muller, Raquel Muñoz Moreno, Cristina Muñoz Pinedo, Christian Münz, Maureen E. Murphy, James T. Murray, Aditya Murthy, Indira U. Mysorekar, Ivan R. Nabi, Massimo Nabissi, Gustavo A. Nader, Yukitoshi Nagahara, Yoshitaka Nagai, Kazuhiro Nagata, Anika Nagelkerke, Péter Nagy, Samisubbu R. Naidu, Sreejayan Nair, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Gennaro Napolitano, Naweed I. Naqvi, Roberta Nardacci, Derek P. Narendra, Masashi Narita, Anna Chiara Nascimbeni, Ramesh Natarajan, Luiz C. Navegantes, Steffan T. Nawrocki, Taras Y. Nazarko, Volodymyr Y. Nazarko, Thomas Neill, Luca M. Neri, Mihai G. Netea, Romana T. Netea Maier, Bruno M. Neves, Paul A. Ney, Ioannis P. Nezis, Hang TT Nguyen, Huu Phuc Nguyen, Anne Sophie Nicot, Hilde Nilsen, Per Nilsson, Mikio Nishimura, Ichizo Nishino, Mireia Niso Santano, Hua Niu, Ralph A. Nixon, Vincent CO Njar, Takeshi Noda, Angelika A. Noegel, Elsie Magdalena Nolte, Erik Norberg, Koenraad K. Norga, Sakineh Kazemi Noureini, Shoji Notomi, Lucia Notterpek, Karin Nowikovsky, Nobuyuki Nukina, Thorsten Nürnberger, Valerie B. O'Donnell, Tracey O'Donovan, Peter J. O'Dwyer, Ina Oehme, Clara L. Oeste, Michinaga Ogawa, Besim Ogretmen, Yuji Ogura, Young J. Oh, Masaki Ohmuraya, Takayuki Ohshima, Rani Ojha, Koji Okamoto, Toshiro Okazaki, F. Javier Oliver, Karin Ollinger, Stefan Olsson, Daniel P. Orban, Paulina Ordonez, Idil Orhon, Laszlo Orosz, Eyleen J. O'Rourke, Helena Orozco, Angel L. Ortega, Elena Ortona, Laura D. Osellame, Junko Oshima, Shigeru Oshima, Heinz D. Osiewacz, Takanobu Otomo, Kinya Otsu, Jing hsiung James Ou, Tiago F. Outeiro, Dong yun Ouyang, Hongjiao Ouyang, Michael Overholtzer, Michelle A. Ozbun, P. Hande Ozdinler, Bulent Ozpolat, Consiglia Pacelli, Paolo Paganetti, Guylène Page, Gilles Pages, Ugo Pagnini, Beata Pajak, Stephen C. Pak, Karolina Pakos Zebrucka, Nazzy Pakpour, Zdena Palková, Francesca Palladino, Kathrin Pallauf, Nicolas Pallet, Marta Palmieri, Søren R. Paludan, Camilla Palumbo, Silvia Palumbo, Olatz Pampliega, Hongming Pan, Wei Pan, Theocharis Panaretakis, Aseem Pandey, Areti Pantazopoulou, Zuzana Papackova, Daniela L. Papademetrio, Issidora Papassideri, Alessio Papini, Nirmala Parajuli, Julian Pardo, Vrajesh V. Parekh, Giancarlo Parenti, Jong In Park, Junsoo Park, Ohkmae K. Park, Roy Parker, Rosanna Parlato, Jan B. Parys, Katherine R. Parzych, Jean Max Pasquet, Benoit Pasquier, Kishore BS Pasumarthi, Daniel Patschan, Cam Patterson, Sophie Pattingre, Scott Pattison, Arnim Pause, Hermann Pavenstädt, Flaminia Pavone, Zully Pedrozo, Fernando J. Peña, Miguel A. Peñalva, Mario Pende, Jianxin Peng, Fabio Penna, Josef M. Penninger, Anna Pensalfini, Salvatore Pepe, Gustavo JS Pereira, Paulo C. Pereira, Verónica Pérez de la Cruz, María Esther Pérez Pérez, Diego Pérez Rodríguez, Dolores Pérez Sala, Celine Perier, Andras Perl, David H. Perlmutter, Ida Perrotta, Shazib Pervaiz, Maija Pesonen, Jeffrey E. Pessin, Godefridus J. Peters, Morten Petersen, Irina Petrache, Basil J. Petrof, Goran Petrovski, James M. Phang, Mauro Piacentini, Marina Pierdominici, Philippe Pierre, Valérie Pierrefite Carle, Federico Pietrocola, Felipe X. Pimentel Muiños, Mario Pinar, Benjamin Pineda, Ronit Pinkas Kramarski, Marcello Pinti, Paolo Pinton, Bilal Piperdi, James M. Piret, Leonidas C. Platanias, Harald W. Platta, Edward D. Plowey, Stefanie Pöggeler, Marc Poirot, Peter Polčic, Angelo Poletti, Audrey H. Poon, Hana Popelka, Blagovesta Popova, Izabela Poprawa, Shibu M. Poulose, Joanna Poulton, Scott K. Powers, Ted Powers, Mercedes Pozuelo Rubio, Krisna Prak, Reinhild Prange, Mark Prescott, Muriel Priault, Sharon Prince, Richard L. Proia, Tassula Proikas Cezanne, Holger Prokisch, Vasilis J. Promponas, Karin Przyklenk, Rosa Puertollano, Subbiah Pugazhenthi, Luigi Puglielli, Aurora Pujol, Julien Puyal, Dohun Pyeon, Xin Qi, Wen bin Qian, Zheng Hong Qin, Yu Qiu, Ziwei Qu, Joe Quadrilatero, Frederick Quinn, Nina Raben, Hannah Rabinowich, Flavia Radogna, Michael J. Ragusa, Mohamed Rahmani, Komal Raina, Sasanka Ramanadham, Rajagopal Ramesh, Abdelhaq Rami, Sarron Randall Demllo, Felix Randow, Hai Rao, V. Ashutosh Rao, Blake B. Rasmussen, Tobias M. Rasse, Edward A. Ratovitski, Pierre Emmanuel Rautou, Swapan K. Ray, Babak Razani, Bruce H. Reed, Fulvio Reggiori, Markus Rehm, Andreas S. Reichert, Theo Rein, David J. Reiner, Eric Reits, Jun Ren, Xingcong Ren, Maurizio Renna, Jane EB Reusch, Jose L. Revuelta, Leticia Reyes, Alireza R. Rezaie, Robert I. Richards, Des R. Richardson, Clémence Richetta, Michael A. Riehle, Bertrand H. Rihn, Yasuko Rikihisa, Brigit E. Riley, Gerald Rimbach, Maria Rita Rippo, Konstantinos Ritis, Federica Rizzi, Elizete Rizzo, Peter J. Roach, Jeffrey Robbins, Michel Roberge, Gabriela Roca, Maria Carmela Roccheri, Sonia Rocha, Cecilia MP Rodrigues, Clara I. Rodríguez, Santiago Rodriguez de Cordoba, Natalia Rodriguez Muela, Jeroen Roelofs, Vladimir V. Rogov, Troy T. Rohn, Bärbel Rohrer, Davide Romanelli, Luigina Romani, Patricia Silvia Romano, M. Isabel G. Roncero, Jose Luis Rosa, Alicia Rosello, Kirill V. Rosen, Philip Rosenstiel, Magdalena Rost Roszkowska, Kevin A. Roth, Gael Roué, Mustapha Rouis, Kasper M. Rouschop, Daniel T. Ruan, Diego Ruano, David C. Rubinsztein, Edmund B. Rucker III, Assaf Rudich, Emil Rudolf, Ruediger Rudolf, Markus A. Ruegg, Carmen Ruiz Roldan, Avnika Ashok Ruparelia, Paola Rusmini, David W. Russ, Gian Luigi Russo, Giuseppe Russo, Rossella Russo, Tor Erik Rusten, Victoria Ryabovol, Kevin M. Ryan, Stefan W. Ryter, David M. Sabatini, Michael Sacher, Carsten Sachse, Michael N. Sack, Junichi Sadoshima, Paul Saftig, Ronit Sagi Eisenberg, Sumit Sahni, Pothana Saikumar, Tsunenori Saito, Tatsuya Saitoh, Koichi Sakakura, Machiko Sakoh Nakatogawa, Yasuhito Sakuraba, María Salazar Roa, Paolo Salomoni, Ashok K. Saluja, Paul M. Salvaterra, Rosa Salvioli, Afshin Samali, Anthony MJ Sanchez, José A. Sánchez Alcázar, Ricardo Sanchez Prieto, Marco Sandri, Miguel A. Sanjuan, Stefano Santaguida, Laura Santambrogio, Giorgio Santoni, Claudia Nunes dos Santos, Shweta Saran, Marco Sardiello, Graeme Sargent, Pallabi Sarkar, Sovan Sarkar, Maria Rosa Sarrias, Minnie M. Sarwal, Chihiro Sasakawa, Motoko Sasaki, Miklos Sass, Ken Sato, Miyuki Sato, Joseph Satriano, Niramol Savaraj, Svetlana Saveljeva, Liliana Schaefer, Ulrich E. Schaible, Michael Scharl, Hermann M. Schatzl, Randy Schekman, Wiep Scheper, Alfonso Schiavi, Hyman M. Schipper, Hana Schmeisser, Jens Schmidt, Ingo Schmitz, Bianca E. Schneider, E. Marion Schneider, Jaime L. Schneider, Eric A. Schon, Miriam J. Schönenberger, Axel H. Schönthal, Daniel F. Schorderet, Bernd Schröder, Sebastian Schuck, Ryan J. Schulze, Melanie Schwarten, Thomas L. Schwarz, Sebastiano Sciarretta, Kathleen Scotto, A. Ivana Scovassi, Robert A. Screaton, Mark Screen, Hugo Seca, Simon Sedej, Laura Segatori, Nava Segev, Per O. Seglen, Jose M. Seguí Simarro, Juan Segura Aguilar, Ekihiro Seki, Iban Seiliez, Christian Sell, Clay F. Semenkovich, Gregg L. Semenza, Utpal Sen, Andreas L. Serra, Ana Serrano Puebla, Hiromi Sesaki, Takao Setoguchi, Carmine Settembre, John J. Shacka, Ayesha N. Shajahan Haq, Irving M. Shapiro, Shweta Sharma, Hua She, C. K. James Shen, Chiung Chyi Shen, Han Ming Shen, Sanbing Shen, Weili Shen, Rui Sheng, Xianyong Sheng, Zu Hang Sheng, Trevor G. Shepherd, Junyan Shi, Qiang Shi, Qinghua Shi, Yuguang Shi, Shusaku Shibutani, Kenichi Shibuya, Yoshihiro Shidoji, Jeng Jer Shieh, Chwen Ming Shih, Yohta Shimada, Shigeomi Shimizu, Dong Wook Shin, Mari L. Shinohara, Michiko Shintani, Takahiro Shintani, Tetsuo Shioi, Ken Shirabe, Ronit Shiri Sverdlov, Orian Shirihai, Gordon C. Shore, Chih Wen Shu, Deepak Shukla, Andriy A. Sibirny, Valentina Sica, Christina J. Sigurdson, Einar M. Sigurdsson, Puran Singh Sijwali, Beata Sikorska, Wilian A. Silveira, Sandrine Silvente Poirot, Gary A. Silverman, Jan Simak, Thomas Simmet, Anna Katharina Simon, Hans Uwe Simon, Cristiano Simone, Matias Simons, Anne Simonsen, Rajat Singh, Shivendra V. Singh, Shrawan K. Singh, Debasish Sinha, Sangita Sinha, Frank A. Sinicrope, Agnieszka Sirko, Kapil Sirohi, Balindiwe JN Sishi, Annie Sittler, Parco M. Siu, Efthimios Sivridis, Anna Skwarska, Ruth Slack, Iva Slaninová, Nikolai Slavov, Soraya S. Smaili, Keiran SM Smalley, Duncan R. Smith, Stefaan J. Soenen, Scott A. Soleimanpour, Anita Solhaug, Kumaravel Somasundaram, Jin H. Son, Avinash Sonawane, Chunjuan Song, Fuyong Song, Hyun Kyu Song, Ju Xian Song, Wei Song, Kai Y. Soo, Anil K. Sood, Tuck Wah Soong, Virawudh Soontornniyomkij, Maurizio Sorice, Federica Sotgia, David R. Soto Pantoja, Areechun Sotthibundhu, Maria João Sousa, Herman P. Spaink, Paul N. Span, Anne Spang, Janet D. Sparks, Peter G. Speck, Stephen A. Spector, Claudia D. Spies, Wolfdieter Springer, Daret St Clair, Alessandra Stacchiotti, Bart Staels, Michael T. Stang, Daniel T. Starczynowski, Petro Starokadomskyy, Clemens Steegborn, John W. Steele, Leonidas Stefanis, Joan Steffan, Christine M. Stellrecht, Harald Stenmark, Tomasz M. Stepkowski, Stęphan T. Stern, Craig Stevens, Brent R. Stockwell, Veronika Stoka, Zuzana Storchova, Björn Stork, Vassilis Stratoulias, Dimitrios J. Stravopodis, Pavel Strnad, Anne Marie Strohecker, Anna Lena Ström, Per Stromhaug, Jiri Stulik, Yu Xiong Su, Zhaoliang Su, Carlos S. Subauste, Srinivasa Subramaniam, Carolyn M. Sue, Sang Won Suh, Xinbing Sui, Supawadee Sukseree, David Sulzer, Fang Lin Sun, Jiaren Sun, Jun Sun, Shi Yong Sun, Yang Sun, Yi Sun, Yingjie Sun, Vinod Sundaramoorthy, Joseph Sung, Hidekazu Suzuki, Kuninori Suzuki, Naoki Suzuki, Tadashi Suzuki, Yuichiro J. Suzuki, Michele S. Swanson, Charles Swanton, Karl Swärd, Ghanshyam Swarup, Sean T. Sweeney, Paul W. Sylvester, Zsuzsanna Szatmari, Eva Szegezdi, Peter W. Szlosarek, Heinrich Taegtmeyer, Marco Tafani, Emmanuel Taillebourg, Stephen WG Tait, Krisztina Takacs Vellai, Yoshinori Takahashi, Szabolcs Takáts, Genzou Takemura, Nagio Takigawa, Nicholas J. Talbot, Elena Tamagno, Jerome Tamburini, Cai Ping Tan, Lan Tan, Mei Lan Tan, Ming Tan, Yee Joo Tan, Keiji Tanaka, Masaki Tanaka, Daolin Tang, Dingzhong Tang, Guomei Tang, Isei Tanida, Kunikazu Tanji, Bakhos A. Tannous, Jose A. Tapia, Inmaculada Tasset Cuevas, Marc Tatar, Iman Tavassoly, Nektarios Tavernarakis, Allen Taylor, Graham S. Taylor, Gregory A. Taylor, J. Paul Taylor, Mark J. Taylor, Elena V. Tchetina, Andrew R. Tee, Fatima Teixeira Clerc, Sucheta Telang, Tewin Tencomnao, Ba Bie Teng, Ru Jeng Teng, Faraj Terro, Gianluca Tettamanti, Arianne L. Theiss, Anne E. Theron, Kelly Jean Thomas, Marcos P. Thomé, Paul G. Thomes, Andrew Thorburn, Jeremy Thorner, Thomas Thum, Michael Thumm, Teresa LM Thurston, Ling Tian, Andreas Till, Jenny Pan yun Ting, Vladimir I. Titorenko, Lilach Toker, Stefano Toldo, Sharon A. Tooze, Ivan Topisirovic, Maria Lyngaas Torgersen, Liliana Torosantucci, Alicia Torriglia, Maria Rosaria Torrisi, Cathy Tournier, Roberto Towns, Vladimir Trajkovic, Leonardo H. Travassos, Gemma Triola, Durga Nand Tripathi, Daniela Trisciuoglio, Rodrigo Troncoso, Ioannis P. Trougakos, Anita C. Truttmann, Kuen Jer Tsai, Mario P. Tschan, Yi Hsin Tseng, Takayuki Tsukuba, Allan Tsung, Andrey S. Tsvetkov, Shuiping Tu, Hsing Yu Tuan, Marco Tucci, David A. Tumbarello, Boris Turk, Vito Turk, Robin FB Turner, Anders A. Tveita, Suresh C. Tyagi, Makoto Ubukata, Yasuo Uchiyama, Andrej Udelnow, Takashi Ueno, Midori Umekawa, Rika Umemiya Shirafuji, Benjamin R. Underwood, Christian Ungermann, Rodrigo P. Ureshino, Ryo Ushioda, Vladimir N. Uversky, Néstor L. Uzcátegui, Thomas Vaccari, Maria I. Vaccaro, Libuše Váchová, Helin Vakifahmetoglu Norberg, Rut Valdor, Enza Maria Valente, Francois Vallette, Angela M. Valverde, Greet Van den Berghe, Ludo Van Den Bosch, Gijs R. van den Brink, F. Gisou van der Goot, Ida J. van der Klei, Luc JW van der Laan, Wouter G. van Doorn, Marjolein van Egmond, Kenneth L. van Golen, Luc Van Kaer, Menno van Lookeren Campagne, Peter Vandenabeele, Wim Vandenberghe, Ilse Vanhorebeek, Isabel Varela Nieto, M. Helena Vasconcelos, Radovan Vasko, Demetrios G. Vavvas, Ignacio Vega Naredo, Guillermo Velasco, Athanassios D. Velentzas, Panagiotis D. Velentzas, Tibor Vellai, Edo Vellenga, Mikkel Holm Vendelbo, Kartik Venkatachalam, Natascia Ventura, Salvador Ventura, Patrícia ST Veras, Mireille Verdier, Beata G. Vertessy, Andrea Viale, Michel Vidal, Helena LA Vieira, Richard D. Vierstra, Nadarajah Vigneswaran, Neeraj Vij, Miquel Vila, Margarita Villar, Victor H. Villar, Joan Villarroya, Cécile Vindis, Giampietro Viola, Maria Teresa Viscomi, Giovanni Vitale, Dan T. Vogl, Olga V. Voitsekhovskaja, Clarissa von Haefen, Karin von Schwarzenberg, Daniel E. Voth, Valérie Vouret Craviari, Kristina Vuori, Jatin M. Vyas, Christian Waeber, Cheryl Lyn Walker, Mark J. Walker, Jochen Walter, Lei Wan, Xiangbo Wan, Bo Wang, Caihong Wang, Chao Yung Wang, Chengshu Wang, Chenran Wang, Chuangui Wang, Dong Wang, Fen Wang, Fuxin Wang, Guanghui Wang, Hai jie Wang, Haichao Wang, Hong Gang Wang, Hongmin Wang, Horng Dar Wang, Jing Wang, Junjun Wang, Mei Wang, Mei Qing Wang, Pei Yu Wang, Peng Wang, Richard C. Wang, Shuo Wang, Ting Fang Wang, Xian Wang, Xiao jia Wang, Xiao Wei Wang, Xin Wang, Xuejun Wang, Yan Wang, Yanming Wang, Ying Wang, Ying Jan Wang, Yipeng Wang, Yu Wang, Yu Tian Wang, Yuqing Wang, Zhi Nong Wang, Pablo Wappner, Carl Ward, Diane McVey Ward, Gary Warnes, Hirotaka Watada, Yoshihisa Watanabe, Kei Watase, Timothy E. Full Terms, Conditions of access, use can be found at h.t.t.p.:././.w.w.w. t.a.n.d.f.o.n.l.i.n.e. com/action/journalInformation?journalCode=kaup20 Download by: [Alma Mater Studiorum Università di Bologna] Date: 23 September 2016, At: 06:43 Weaver, Colin D. Weekes, Jiwu Wei, Thomas Weide, Conrad C. Weihl, Günther Weindl, Simone Nardin Weis, Longping Wen, Xin Wen, Yunfei Wen, Benedikt Westermann, Cornelia M. Weyand, Anthony R. White, Eileen White, J. Lindsay Whitton, Alexander J. Whitworth, Joëlle Wiels, Franziska Wild, Manon E. Wildenberg, Tom Wileman, Deepti Srinivas Wilkinson, Simon Wilkinson, Dieter Willbold, Chris Williams, Katherine Williams, Peter R. Williamson, Konstanze F. Winklhofer, Steven S. Witkin, Stephanie E. Wohlgemuth, Thomas Wollert, Ernst J. Wolvetang, Esther Wong, G. William Wong, Richard W. Wong, Vincent Kam Wai Wong, Elizabeth A. Woodcock, Karen L. Wright, Chunlai Wu, Defeng Wu, Gen Sheng Wu, Jian Wu, Junfang Wu, Mian Wu, Min Wu, Shengzhou Wu, William KK Wu, Yaohua Wu, Zhenlong Wu, Cristina PR Xavier, Ramnik J. Xavier, Gui Xian Xia, Tian Xia, Weiliang Xia, Yong Xia, Hengyi Xiao, Jian Xiao, Shi Xiao, Wuhan Xiao, Chuan Ming Xie, Zhiping Xie, Zhonglin Xie, Maria Xilouri, Yuyan Xiong, Chuanshan Xu, Congfeng Xu, Feng Xu, Haoxing Xu, Hongwei Xu, Jian Xu, Jianzhen Xu, Jinxian Xu, Liang Xu, Xiaolei Xu, Yangqing Xu, Ye Xu, Zhi Xiang Xu, Ziheng Xu, Yu Xue, Takahiro Yamada, Ai Yamamoto, Koji Yamanaka, Shunhei Yamashina, Shigeko Yamashiro, Bing Yan, Bo Yan, Xianghua Yan, Zhen Yan, Yasuo Yanagi, Dun Sheng Yang, Jin Ming Yang, Liu Yang, Minghua Yang, Pei Ming Yang, Peixin Yang, Qian Yang, Wannian Yang, Wei Yuan Yang, Xuesong Yang, Yi Yang, Ying Yang, Zhifen Yang, Zhihong Yang, Meng Chao Yao, Pamela J. Yao, Xiaofeng Yao, Zhenyu Yao, Zhiyuan Yao, Linda S. Yasui, Mingxiang Ye, Barry Yedvobnick, Behzad Yeganeh, Elizabeth S. Yeh, Patricia L. Yeyati, Fan Yi, Long Yi, Xiao Ming Yin, Calvin K. Yip, Yeong Min Yoo, Young Hyun Yoo, Seung Yong Yoon, Ken Ichi Yoshida, Tamotsu Yoshimori, Ken H. Young, Huixin Yu, Jane J. Yu, Jin Tai Yu, Jun Yu, Li Yu, W. Haung Yu, Xiao Fang Yu, Zhengping Yu, Junying Yuan, Zhi Min Yuan, Beatrice YJT Yue, Jianbo Yue, Zhenyu Yue, David N. Zacks, Eldad Zacksenhaus, Nadia Zaffaroni, Tania Zaglia, Zahra Zakeri, Vincent Zecchini, Jinsheng Zeng, Min Zeng, Qi Zeng, Antonis S. Zervos, Donna D. Zhang, Fan Zhang, Guo Zhang, Guo Chang Zhang, Hao Zhang, Hong Zhang, Hongbing Zhang, Jian Zhang, Jiangwei Zhang, Jianhua Zhang, Jing pu Zhang, Li Zhang, Lin Zhang, Long Zhang, Ming Yong Zhang, Xiangnan Zhang, Xu Dong Zhang, Yan Zhang, Yang Zhang, Yanjin Zhang, Yingmei Zhang, Yunjiao Zhang, Mei Zhao, Wei Li Zhao, Xiaonan Zhao, Yan G. Zhao, Ying Zhao, Yongchao Zhao, Yu xia Zhao, Zhendong Zhao, Zhizhuang J. Zhao, Dexian Zheng, Xi Long Zheng, Xiaoxiang Zheng, Boris Zhivotovsky, Qing Zhong, Guang Zhou Zhou, Guofei Zhou, Huiping Zhou, Shu Feng Zhou, Xu jie Zhou, Hongxin Zhu, Hua Zhu, Wei Guo Zhu, Wenhua Zhu, Xiao Feng Zhu, Yuhua Zhu, Shi Mei Zhuang, Xiaohong Zhuang, Elio Ziparo, Christos E. Zois, Teresa Zoladek, Wei Xing Zong, Antonio Zorzano, Susu M. Zughaier, Life Sciences Institute and Department of Molecular, Cellular, and Developmental Biology and Biological Chemistry, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Tokyo Medical University, The Hebrew University of Jerusalem (HUJ), Mammalian Genetics Unit, Medical Research Council Harwell, University of Occupational and Environmental Health School of Medicine, Partenaires INRAE, University of Toronto, Ben-Gurion University of the Negev (BGU), University of Colorado [Boulder], Cell Death Research & Therapy (CDRT) Lab, Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Vienna [Vienna], Conway Institute of Biomolecular and Biomedical Research and School of Chemical and Bioprocess Engineering, University College Dublin [Dublin] (UCD), Georgetown University, Candiolo Cancer Institute (IRCCS), Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Ikerbasque - Basque Foundation for Science, Cleveland Clinic, Sidney Kimmel Cancer Center, Jefferson (Philadelphia University + Thomas Jefferson University), Universidad de Buenos Aires (UBA), Department of Clinical Neurosciences, University College of London [London] (UCL)-Institute of Neurology, Thérapie génique, Génomique et Epigénomique (U 1169), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Consiglio Nazionale delle Ricerche (CNR), Osaka University, Department of Experimental Medicine and Public Health, University of Camerino, University of Barcelona, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7), Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Physics, Technical University of Denmark [Lyngby] (DTU), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Department of Pharmaco-Biology, Università della Calabria [Arcavacata di Rende] (Unical), Fondation Universitaire Notre Dame de la Paix (FUNDP), Facultés Universitaires Notre Dame de la Paix (FUNDP), USC Neuromuscular Center, Department of Neurology, University of Southern California (USC), Physiopathologie de la survie et de la mort cellulaire et infection virale, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Giannina Gaslini Institute, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Inner Mongolia Agricultural University (IMAU), Politecnico di Milano [Milan] (POLIMI), Department of Civil, Geological, and Mining Engineering, École Polytechnique de Montréal (EPM)-NSERC Industrial Chair on Drinking Water, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Department of Molecular Medicine, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Experimental Virology - Department of Medical Microbiology [Amsterdam, The Netherlands], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA)-Center for Infection and Immunity Amsterdam - CINIMA [Amsterdam, The Netherlands], Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Dynamique des interactions membranaires normales et pathologiques (DIMNP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1), Department of Internal Medicine, Hospital Universitario Infanta Sofía, Celullar and Molecular Medicine, Infection bactérienne, inflammation, et carcinogenèse digestive, University of Edinburgh, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Faculty of Engineering and Natural Sciences, Sabanci University [Istanbul], University of Science and Technology Beijing [Beijing] (USTB), Centre for Computational and Systems Biology (COSBI), Sun Yat-Sen University [Guangzhou] (SYSU), Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA), CAS Institute of Oceanology (IOCAS), Chinese Academy of Sciences [Beijing] (CAS), Polytechnic University of Marche, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cell Biology, Physiology and Immunology, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Pisa - Università di Pisa, Dulbecco Telethon Institute/Department of Biology, Fondation de Recherche Cancer et Sang - Hôpital Kirchberg, China University of Petroleum, Unilever R&D, University of Queensland [Brisbane], University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Laboratoire de Génie des Procédés et Matériaux - EA 4038 (LGPM), CentraleSupélec, Institute for Advanced Study [Tsinghua], Tsinghua University [Beijing] (THU), Nanayang Technological University (NTU), Nanayang Technological University, Institute of Microelectronics [Beijing] (IMETU), Laboratoire de photonique et de nanostructures (LPN), Centre National de la Recherche Scientifique (CNRS), Institut de biologie moléculaire des plantes (IBMP), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Northwestern Polytechnical University [Xi'an] (NPU), University of Pennsylvania [Philadelphia], City University of Hong Kong (CityU), Department of Mathematics [Berkeley], University of California [Berkeley], University of California-University of California, ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, University of Cincinnati (UC), Réponses immunes : régulation et développement, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), The University of New Mexico [Albuquerque], Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Biomediche, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Department of Experimental Medicine and Oncology, University of Turin, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), CNV, University of Valparaiso, Université Paris 1 Panthéon-Sorbonne - UFR d'Arts plastiques et sciences de l'art (UP1 UFR04), Université Paris 1 Panthéon-Sorbonne (UP1), Department of General, Visceral and Vascular Surgery [Jena], Friedrich-Schiller-Universität Jena, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Réseau International des Instituts Pasteur (RIIP), Macrophages et Développement de l’Immunité, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris], Trafic membranaire et Division cellulaire - Membrane Traffic and Cell Division, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Cibles thérapeutiques, formulation et expertise pré-clinique du médicament (CITHEFOR), Université de Lorraine (UL), This work was supported in part by the National Institutes of Health, including Public Health Service grant GM053396 to D.J.K. Due to space and other limitations, it is not possible to include all other sources of financial support., In a rapidly expanding and highly dynamic field such as autophagy, it is possible that some authors who should have been included on this article have been missed. D.J.K. extends his apologies to researchers in the field of autophagy who, due to oversight or any other reason, could not be included on this article. I also note that two of our colleagues on this manuscript have passed away: Arlette Darfeuille-Michaud and Wouter van Doorn., Life Sciences Institute [Ann Arbor, MI, USA], Laboratoire de Biogenèse Membranaire, CNRS UMR 5200, Université de Bordeaux, INRA Bordeaux Aquitaine, Villenave d'Ornon, France., Amelio, Ivano [0000-0002-9126-5391], Beale, Rupert [0000-0002-6705-8560], Floto, Andres [0000-0002-2188-5659], Frezza, Christian [0000-0002-3293-7397], Ktistakis, Nicholas [0000-0001-9397-2914], Melino, Gerry [0000-0001-9428-5972], Narita, Masashi [0000-0001-7764-577X], Rubinsztein, David [0000-0001-5002-5263], Underwood, Benjamin [0000-0003-3427-9487], Whitworth, Alex [0000-0002-1154-6629], Apollo - University of Cambridge Repository, Université Catholique de Louvain, Facultés Universitaires Notre-Dame de la Paix, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR50-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), Department of Clinical and Molecular Medicine, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' [Rome], Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Sun Yat-Sen University (SYSU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), University of Minnesota [Twin Cities], Tsinghua University [Beijing], Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne - UFR d'Arts plastiques et sciences de l'art (UP1 UFR04), Université Panthéon-Sorbonne (UP1), Récepteurs nucléaires, maladies cardiovasculaires et diabète (EGID), Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Necker - Enfants Malades [AP-HP], Trafic membranaire et Division cellulaire, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Klionsky, D., Abdelmohsen, K., Abe, A., Abedin, M., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C., Adams, P., Adeli, K., Adhihetty, P., Adler, S., Agam, G., Agarwal, R., Aghi, M., Agnello, M., Agostinis, P., Aguilar, P., Aguirre-Ghiso, J., Airoldi, E., Ait-Si-Ali, S., Akematsu, T., Akporiaye, E., Al-Rubeai, M., Albaiceta, G., Albanese, C., Albani, D., Albert, M., Aldudo, J., Algül, H., Alirezaei, M., Alloza, I., Almasan, A., Almonte-Beceril, M., Alnemri, E., Alonso, C., Altan-Bonnet, N., Altieri, D., Alvarez, S., Alvarez-Erviti, L., Alves, S., Amadoro, G., Amano, A., Amantini, C., Ambrosio, S., Amelio, I., Amer, A., Amessou, M., Amon, A., An, Z., Anania, F., Andersen, S., Andley, U., Andreadi, C., Andrieu-Abadie, N., Anel, A., Ann, D., Anoopkumar-Dukie, S., Antonioli, M., Aoki, H., Apostolova, N., Aquila, S., Aquilano, K., Araki, K., Arama, E., Aranda, A., Araya, J., Arcaro, A., Arias, E., Arimoto, H., Ariosa, A., Armstrong, J., Arnould, T., Arsov, I., Asanuma, K., Askanas, V., Asselin, E., Atarashi, R., Atherton, S., Atkin, J., Attardi, L., Auberger, P., Auburger, G., Aurelian, L., Autelli, R., Avagliano, L., Avantaggiati, M., Avrahami, L., Awale, S., Azad, N., Bachetti, T., Backer, J., Bae, D., Bae, J., Bae, O., Bae, S., Baehrecke, E., Baek, S., Baghdiguian, S., Bagniewska-Zadworna, A., Bai, H., Bai, J., Bai, X., Bailly, Y., Balaji, K., Balduini, W., Ballabio, A., Balzan, R., Banerjee, R., Bánhegyi, G., Bao, H., Barbeau, B., Barrachina, M., Barreiro, E., Bartel, B., Bartolomé, A., Bassham, D., Bassi, M., Bast, R., Basu, A., Batista, M., Batoko, H., Battino, M., Bauckman, K., Baumgarner, B., Bayer, K., Beale, R., Beaulieu, J., Beck, G., Becker, C., Beckham, J., Bédard, P., Bednarski, P., Begley, T., Behl, C., Behrends, C., Behrens, G., Behrns, K., Bejarano, E., Belaid, A., Belleudi, F., Bénard, G., Berchem, G., Bergamaschi, D., Bergami, M., Berkhout, B., Berliocchi, L., Bernard, A., Bernard, M., Bernassola, F., Bertolotti, A., Bess, A., Besteiro, S., Bettuzzi, S., Bhalla, S., Bhattacharyya, S., Bhutia, S., Biagosch, C., Bianchi, M., Biard-Piechaczyk, M., Billes, V., Bincoletto, C., Bingol, B., Bird, S., Bitoun, M., Bjedov, I., Blackstone, C., Blanc, L., Blanco, G., Blomhoff, H., Boada-Romero, E., Böckler, S., Boes, M., Boesze-Battaglia, K., Boise, L., Bolino, A., Boman, A., Bonaldo, P., Bordi, M., Bosch, J., Botana, L., Botti, J., Bou, G., Bouché, M., Bouchecareilh, M., Boucher, M., Boulton, M., Bouret, S., Boya, P., Boyer-Guittaut, M., Bozhkov, P., Brady, N., Braga, V., Brancolini, C., Braus, G., Bravo-San Pedro, J., Brennan, L., Bresnick, E., Brest, P., Bridges, D., Bringer, M., Brini, M., Brito, G., Brodin, B., Brookes, P., Brown, E., Brown, K., Broxmeyer, H., Bruhat, A., Brum, P., Brumell, J., Brunetti-Pierri, N., Bryson-Richardson, R., Buch, S., Buchan, A., Budak, H., Bulavin, D., Bultman, S., Bultynck, G., Bumbasirevic, V., Burelle, Y., Burke, R., Burmeister, M., Bütikofer, P., Caberlotto, L., Cadwell, K., Cahova, M., Cai, D., Cai, J., Cai, Q., Calatayud, S., Camougrand, N., Campanella, M., Campbell, G., Campbell, M., Campello, S., Candau, R., Caniggia, I., Cantoni, L., Cao, L., Caplan, A., Caraglia, M., Cardinali, C., Cardoso, S., Carew, J., Carleton, L., Carlin, C., Carloni, S., Carlsson, S., Carmona-Gutierrez, D., Carneiro, L., Carnevali, O., Carra, S., Carrier, A., Carroll, B., Casas, C., Casas, J., Cassinelli, G., Castets, P., Castro-Obregon, S., Cavallini, G., Ceccherini, I., Cecconi, F., Cederbaum, A., Ceña, V., Cenci, S., Cerella, C., Cervia, D., Cetrullo, S., Chaachouay, H., Chae, H., Chagin, A., Chai, C., Chakrabarti, G., Chamilos, G., Chan, E., Chan, M., Chandra, D., Chandra, P., Chang, C., Chang, R., Chang, T., Chatham, J., Chatterjee, S., Chauhan, S., Che, Y., Cheetham, M., Cheluvappa, R., Chen, C., Chen, G., Chen, H., Chen, J., Chen, M., Chen, P., Chen, Q., Chen, S., Chen, W., Chen, X., Chen, Y., Chen, Z., Cheng, A., Cheng, C., Cheng, H., Cheong, H., Cherry, S., Chesney, J., Cheung, C., Chevet, E., Chi, H., Chi, S., Chiacchiera, F., Chiang, H., Chiarelli, R., Chiariello, M., Chieppa, M., Chin, L., Chiong, M., Chiu, G., Cho, D., Cho, S., Cho, W., Cho, Y., Choi, A., Choi, E., Choi, J., Choi, M., Choi, S., Chou, T., Chouaib, S., Choubey, D., Choubey, V., Chow, K., Chowdhury, K., Chu, C., Chuang, T., Chun, T., Chung, H., Chung, T., Chung, Y., Chwae, Y., Cianfanelli, V., Ciarcia, R., Ciechomska, I., Ciriolo, M., Cirone, M., Claerhout, S., Clague, M., Clària, J., Clarke, P., Clarke, R., Clementi, E., Cleyrat, C., Cnop, M., Coccia, E., Cocco, T., Codogno, P., Coers, J., Cohen, E., Colecchia, D., Coletto, L., Coll, N., Colucci-Guyon, E., Comincini, S., Condello, M., Cook, K., Coombs, G., Cooper, C., Cooper, J., Coppens, I., Corasaniti, M., Corazzari, M., Corbalan, R., Corcelle-Termeau, E., Cordero, M., Corral-Ramos, C., Corti, O., Cossarizza, A., Costelli, P., Costes, S., Cotman, S., Coto-Montes, A., Cottet, S., Couve, E., Covey, L., Cowart, L., Cox, J., Coxon, F., Coyne, C., Cragg, M., Craven, R., Crepaldi, T., Crespo, J., Criollo, A., Crippa, V., Cruz, M., Cuervo, A., Cuezva, J., Cui, T., Cutillas, P., Czaja, M., Czyzyk-Krzeska, M., Dagda, R., Dahmen, U., Dai, C., Dai, W., Dai, Y., Dalby, K., Dalla Valle, L., Dalmasso, G., D'Amelio, M., Damme, M., Darfeuille-Michaud, A., Dargemont, C., Darley-Usmar, V., Dasarathy, S., Dasgupta, B., Dash, S., Dass, C., Davey, H., Davids, L., Dávila, D., Davis, R., Dawson, T., Dawson, V., Daza, P., de Belleroche, J., de Figueiredo, P., de Figueiredo, R., de la Fuente, J., De Martino, L., De Matteis, A., De Meyer, G., De Milito, A., De Santi, M., de Souza, W., De Tata, V., De Zio, D., Debnath, J., Dechant, R., Decuypere, J., Deegan, S., Dehay, B., Del Bello, B., Del Re, D., Delage-Mourroux, R., Delbridge, L., Deldicque, L., Delorme-Axford, E., Deng, Y., Dengjel, J., Denizot, M., Dent, P., Der, C., Deretic, V., Derrien, B., Deutsch, E., Devarenne, T., Devenish, R., Di Bartolomeo, S., Di Daniele, N., Di Domenico, F., Di Nardo, A., Di Paola, S., Di Pietro, A., Di Renzo, L., Diantonio, A., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M., Diaz-Nido, J., Dickey, C., Dickson, R., Diederich, M., Digard, P., Dikic, I., Dinesh-Kumar, S., Ding, C., Ding, W., Ding, Z., Dini, L., Distler, J., Diwan, A., Djavaheri-Mergny, M., Dmytruk, K., Dobson, R., Doetsch, V., Dokladny, K., Dokudovskaya, S., Donadelli, M., Dong, X., Dong, Z., Donohue, T., Doran, K., D'Orazi, G., Dorn, G., Dosenko, V., Dridi, S., Drucker, L., Du, J., Du, L., du Toit, A., Dua, P., Duan, L., Duann, P., Dubey, V., Duchen, M., Duchosal, M., Duez, H., Dugail, I., Dumit, V., Duncan, M., Dunlop, E., Dunn, W., Dupont, N., Dupuis, L., Durán, R., Durcan, T., Duvezin-Caubet, S., Duvvuri, U., Eapen, V., Ebrahimi-Fakhari, D., Echard, A., Eckhart, L., Edelstein, C., Edinger, A., Eichinger, L., Eisenberg, T., Eisenberg-Lerner, A., Eissa, N., El-Deiry, W., El-Khoury, V., Elazar, Z., Eldar-Finkelman, H., Elliott, C., Emanuele, E., Emmenegger, U., Engedal, N., Engelbrecht, A., Engelender, S., Enserink, J., Erdmann, R., Erenpreisa, J., Eri, R., Eriksen, J., Erman, A., Escalante, R., Eskelinen, E., Espert, L., Esteban-Martínez, L., Evans, T., Fabri, M., Fabrias, G., Fabrizi, C., Facchiano, A., Færgeman, N., Faggioni, A., Fairlie, W., Fan, C., Fan, D., Fan, J., Fang, S., Fanto, M., Fanzani, A., Farkas, T., Faure, M., Favier, F., Fearnhead, H., Federici, M., Fei, E., Felizardo, T., Feng, H., Feng, Y., Ferguson, T., Fernández, Á., Fernandez-Barrena, M., Fernandez-Checa, J., Fernández-López, A., Fernandez-Zapico, M., Feron, O., Ferraro, E., Ferreira-Halder, C., Fesus, L., Feuer, R., Fiesel, F., Filippi-Chiela, E., Filomeni, G., Fimia, G., Fingert, J., Finkbeiner, S., Finkel, T., Fiorito, F., Fisher, P., Flajolet, M., Flamigni, F., Florey, O., Florio, S., Floto, R., Folini, M., Follo, C., Fon, E., Fornai, F., Fortunato, F., Fraldi, A., Franco, R., Francois, A., François, A., Frankel, L., Fraser, I., Frey, N., Freyssenet, D., Frezza, C., Friedman, S., Frigo, D., Fu, D., Fuentes, J., Fueyo, J., Fujitani, Y., Fujiwara, Y., Fujiya, M., Fukuda, M., Fulda, S., Fusco, C., Gabryel, B., Gaestel, M., Gailly, P., Gajewska, M., Galadari, S., Galili, G., Galindo, I., Galindo, M., Galliciotti, G., Galluzzi, L., Galy, V., Gammoh, N., Gandy, S., Ganesan, A., Ganesan, S., Ganley, I., Gannagé, M., Gao, F., Gao, J., García Nannig, L., García Véscovi, E., Garcia-Macía, M., Garcia-Ruiz, C., Garg, A., Garg, P., Gargini, R., Gassen, N., Gatica, D., Gatti, E., Gavard, J., Gavathiotis, E., Ge, L., Ge, P., Ge, S., Gean, P., Gelmetti, V., Genazzani, A., Geng, J., Genschik, P., Gerner, L., Gestwicki, J., Gewirtz, D., Ghavami, S., Ghigo, E., Ghosh, D., Giammarioli, A., Giampieri, F., Giampietri, C., Giatromanolaki, A., Gibbings, D., Gibellini, L., Gibson, S., Ginet, V., Giordano, A., Giorgini, F., Giovannetti, E., Girardin, S., Gispert, S., Giuliano, S., Gladson, C., Glavic, A., Gleave, M., Godefroy, N., Gogal, R., Gokulan, K., Goldman, G., Goletti, D., Goligorsky, M., Gomes, A., Gomes, L., Gomez, H., Gomez-Manzano, C., Gómez-Sánchez, R., Gonçalves, D., Goncu, E., Gong, Q., Gongora, C., Gonzalez, C., Gonzalez-Alegre, P., Gonzalez-Cabo, P., González-Polo, R., Goping, I., Gorbea, C., Gorbunov, N., Goring, D., Gorman, A., Gorski, S., Goruppi, S., Goto-Yamada, S., Gotor, C., Gottlieb, R., Gozes, I., Gozuacik, D., Graba, Y., Graef, M., Granato, G., Grant, G., Grant, S., Gravina, G., Green, D., Greenhough, A., Greenwood, M., Grimaldi, B., Gros, F., Grose, C., Groulx, J., Gruber, F., Grumati, P., Grune, T., Guan, J., Guan, K., Guerra, B., Guillen, C., Gulshan, K., Gunst, J., Guo, C., Guo, L., Guo, M., Guo, W., Guo, X., Gust, A., Gustafsson, Å., Gutierrez, E., Gutierrez, M., Gwak, H., Haas, A., Haber, J., Hadano, S., Hagedorn, M., Hahn, D., Halayko, A., Hamacher-Brady, A., Hamada, K., Hamai, A., Hamann, A., Hamasaki, M., Hamer, I., Hamid, Q., Hammond, E., Han, F., Han, W., Handa, J., Hanover, J., Hansen, M., Harada, M., Harhaji-Trajkovic, L., Harper, J., Harrath, A., Harris, A., Harris, J., Hasler, U., Hasselblatt, P., Hasui, K., Hawley, R., Hawley, T., He, C., He, F., He, G., He, R., He, X., He, Y., Heath, J., Hébert, M., Heinzen, R., Helgason, G., Hensel, M., Henske, E., Her, C., Herman, P., Hernández, A., Hernandez, C., Hernández-Tiedra, S., Hetz, C., Hiesinger, P., Higaki, K., Hilfiker, S., Hill, B., Hill, J., Hill, W., Hino, K., Hofius, D., Hofman, P., Höglinger, G., Höhfeld, J., Holz, M., Hong, Y., Hood, D., Hoozemans, J., Hoppe, T., Hsu, C., Hsu, L., Hu, D., Hu, G., Hu, H., Hu, M., Hu, Y., Hu, Z., Hua, F., Hua, Y., Huang, C., Huang, H., Huang, K., Huang, S., Huang, W., Huang, Y., Huber, T., Huebbe, P., Huh, W., Hulmi, J., Hur, G., Hurley, J., Husak, Z., Hussain, S., Hwang, J., Hwang, S., Hwang, T., Ichihara, A., Imai, Y., Imbriano, C., Inomata, M., Into, T., Iovane, V., Iovanna, J., Iozzo, R., Ip, N., Irazoqui, J., Iribarren, P., Isaka, Y., Isakovic, A., Ischiropoulos, H., Isenberg, J., Ishaq, M., Ishida, H., Ishii, I., Ishmael, J., Isidoro, C., Isobe, K., Isono, E., Issazadeh-Navikas, S., Itahana, K., Itakura, E., Ivanov, A., Iyer, A., Izquierdo, J., Izumi, Y., Izzo, V., Jäättelä, M., Jaber, N., Jackson, D., Jackson, W., Jacob, T., Jacques, T., Jagannath, C., Jain, A., Jana, N., Jang, B., Jani, A., Janji, B., Jannig, P., Jansson, P., Jean, S., Jendrach, M., Jeon, J., Jessen, N., Jeung, E., Jia, K., Jia, L., Jiang, H., Jiang, L., Jiang, T., Jiang, X., Jiang, Y., Jiménez, A., Jin, C., Jin, H., Jin, L., Jin, M., Jin, S., Jinwal, U., Jo, E., Johansen, T., Johnson, D., Johnson, G., Johnson, J., Jonasch, E., Jones, C., Joosten, L., Jordan, J., Joseph, A., Joseph, B., Joubert, A., Ju, D., Ju, J., Juan, H., Juenemann, K., Juhász, G., Jung, H., Jung, J., Jung, Y., Jungbluth, H., Justice, M., Jutten, B., Kaakoush, N., Kaarniranta, K., Kaasik, A., Kabuta, T., Kaeffer, B., Kågedal, K., Kahana, A., Kajimura, S., Kakhlon, O., Kalia, M., Kalvakolanu, D., Kamada, Y., Kambas, K., Kaminskyy, V., Kampinga, H., Kandouz, M., Kang, C., Kang, R., Kang, T., Kanki, T., Kanneganti, T., Kanno, H., Kanthasamy, A., Kantorow, M., Kaparakis-Liaskos, M., Kapuy, O., Karantza, V., Karim, M., Karmakar, P., Kaser, A., Kaushik, S., Kawula, T., Kaynar, A., Ke, P., Ke, Z., Kehrl, J., Keller, K., Kemper, J., Kenworthy, A., Kepp, O., Kern, A., Kesari, S., Kessel, D., Ketteler, R., Kettelhut, I., Khambu, B., Khan, M., Khandelwal, V., Khare, S., Kiang, J., Kiger, A., Kihara, A., Kim, A., Kim, C., Kim, D., Kim, E., Kim, H., Kim, J., Kim, K., Kim, M., Kim, P., Kim, S., Kim, Y., Kimchi, A., Kimmelman, A., Kimura, T., King, J., Kirkegaard, K., Kirkin, V., Kirshenbaum, L., Kishi, S., Kitajima, Y., Kitamoto, K., Kitaoka, Y., Kitazato, K., Kley, R., Klimecki, W., Klinkenberg, M., Klucken, J., Knævelsrud, H., Knecht, E., Knuppertz, L., Ko, J., Kobayashi, S., Koch, J., Koechlin-Ramonatxo, C., Koenig, U., Koh, Y., Köhler, K., Kohlwein, S., Koike, M., Komatsu, M., Kominami, E., Kong, D., Kong, H., Konstantakou, E., Kopp, B., Korcsmaros, T., Korhonen, L., Korolchuk, V., Koshkina, N., Kou, Y., Koukourakis, M., Koumenis, C., Kovács, A., Kovács, T., Kovacs, W., Koya, D., Kraft, C., Krainc, D., Kramer, H., Kravic-Stevovic, T., Krek, W., Kretz-Remy, C., Krick, R., Krishnamurthy, M., Kriston-Vizi, J., Kroemer, G., Kruer, M., Kruger, R., Ktistakis, N., Kuchitsu, K., Kuhn, C., Kumar, A., Kumar, D., Kumar, R., Kumar, S., Kundu, M., Kung, H., Kuno, A., Kuo, S., Kuret, J., Kurz, T., Kwok, T., Kwon, T., Kwon, Y., Kyrmizi, I., La Spada, A., Lafont, F., Lahm, T., Lakkaraju, A., Lam, T., Lamark, T., Lancel, S., Landowski, T., Lane, D., Lane, J., Lanzi, C., Lapaquette, P., Lapierre, L., Laporte, J., Laukkarinen, J., Laurie, G., Lavandero, S., Lavie, L., Lavoie, M., Law, B., Law, H., Law, K., Layfield, R., Lazo, P., Le Cam, L., Le Roch, K., Le Stunff, H., Leardkamolkarn, V., Lecuit, M., Lee, B., Lee, C., Lee, E., Lee, G., Lee, H., Lee, J., Lee, M., Lee, P., Lee, S., Lee, Y., Leeuwenburgh, C., Lefort, S., Legouis, R., Lei, J., Lei, Q., Leib, D., Leibowitz, G., Lekli, I., Lemaire, S., Lemasters, J., Lemberg, M., Lemoine, A., Leng, S., Lenz, G., Lenzi, P., Lerman, L., Lettieri Barbato, D., Leu, J., Leung, H., Levine, B., Lewis, P., Lezoualc'H, F., Li, C., Li, F., Li, J., Li, K., Li, L., Li, M., Li, Q., Li, R., Li, S., Li, W., Li, X., Li, Y., Lian, J., Liang, C., Liang, Q., Liao, Y., Liberal, J., Liberski, P., Lie, P., Lieberman, A., Lim, H., Lim, K., Lima, R., Lin, C., Lin, F., Lin, K., Lin, P., Lin, T., Lin, W., Lin, Y., Linden, R., Lindholm, D., Lindqvist, L., Lingor, P., Linkermann, A., Liotta, L., Lipinski, M., Lira, V., Lisanti, M., Liton, P., Liu, B., Liu, C., Liu, F., Liu, H., Liu, J., Liu, K., Liu, L., Liu, Q., Liu, R., Liu, S., Liu, W., Liu, X., Liu, Y., Liu, Z., Liuzzi, J., Lizard, G., Ljujic, M., Lodhi, I., Logue, S., Lokeshwar, B., Long, Y., Lonial, S., Loos, B., López-Otín, C., López-Vicario, C., Lorente, M., Lorenzi, P., Lõrincz, P., Los, M., Lotze, M., Lovat, P., Lu, B., Lu, J., Lu, Q., Lu, S., Lu, Y., Luciano, F., Luckhart, S., Lucocq, J., Ludovico, P., Lugea, A., Lukacs, N., Lum, J., Lund, A., Luo, H., Luo, J., Luo, S., Luparello, C., Lyons, T., Ma, J., Ma, Y., Ma, Z., Machado, J., Machado-Santelli, G., Macian, F., Macintosh, G., Mackeigan, J., Macleod, K., Macmicking, J., MacMillan-Crow, L., Madeo, F., Madesh, M., Madrigal-Matute, J., Maeda, A., Maeda, T., Maegawa, G., Maellaro, E., Maes, H., Magariños, M., Maiese, K., Maiti, T., Maiuri, L., Maiuri, M., Maki, C., Malli, R., Malorni, W., Maloyan, A., Mami-Chouaib, F., Man, N., Mancias, J., Mandelkow, E., Mandell, M., Manfredi, A., Manié, S., Manzoni, C., Mao, K., Mao, Z., Marambaud, P., Marconi, A., Marelja, Z., Marfe, G., Margeta, M., Margittai, E., Mari, M., Mariani, F., Marin, C., Marinelli, S., Mariño, G., Markovic, I., Marquez, R., Martelli, A., Martens, S., Martin, K., Martin, S., Martin-Acebes, M., Martín-Sanz, P., Martinand-Mari, C., Martinet, W., Martinez, J., Martinez-Lopez, N., Martinez-Outschoorn, U., Martínez-Velázquez, M., Martinez-Vicente, M., Martins, W., Mashima, H., Mastrianni, J., Matarese, G., Matarrese, P., Mateo, R., Matoba, S., Matsumoto, N., Matsushita, T., Matsuura, A., Matsuzawa, T., Mattson, M., Matus, S., Maugeri, N., Mauvezin, C., Mayer, A., Maysinger, D., Mazzolini, G., Mcbrayer, M., Mccall, K., Mccormick, C., Mcinerney, G., Mciver, S., Mckenna, S., Mcmahon, J., Mcneish, I., Mechta-Grigoriou, F., Medema, J., Medina, D., Megyeri, K., Mehrpour, M., Mehta, J., Mei, Y., Meier, U., Meijer, A., Meléndez, A., Melino, G., Melino, S., de Melo, E., Mena, M., Meneghini, M., Menendez, J., Menezes, R., Meng, L., Meng, S., Menghini, R., Menko, A., Menna-Barreto, R., Menon, M., Meraz-Ríos, M., Merla, G., Merlini, L., Merlot, A., Meryk, A., Meschini, S., Meyer, J., Mi, M., Miao, C., Micale, L., Michaeli, S., Michiels, C., Migliaccio, A., Mihailidou, A., Mijaljica, D., Mikoshiba, K., Milan, E., Miller-Fleming, L., Mills, G., Mills, I., Minakaki, G., Minassian, B., Ming, X., Minibayeva, F., Minina, E., Mintern, J., Minucci, S., Miranda-Vizuete, A., Mitchell, C., Miyamoto, S., Miyazawa, K., Mizushima, N., Mnich, K., Mograbi, B., Mohseni, S., Moita, L., Molinari, M., Møller, A., Mollereau, B., Mollinedo, F., Mongillo, M., Monick, M., Montagnaro, S., Montell, C., Moore, D., Moore, M., Mora-Rodriguez, R., Moreira, P., Morel, E., Morelli, M., Moreno, S., Morgan, M., Moris, A., Moriyasu, Y., Morrison, J., Morrison, L., Morselli, E., Moscat, J., Moseley, P., Mostowy, S., Motori, E., Mottet, D., Mottram, J., Moussa, C., Mpakou, V., Mukhtar, H., Mulcahy Levy, J., Muller, S., Muñoz-Moreno, R., Muñoz-Pinedo, C., Münz, C., Murphy, M., Murray, J., Murthy, A., Mysorekar, I., Nabi, I., Nabissi, M., Nader, G., Nagahara, Y., Nagai, Y., Nagata, K., Nagelkerke, A., Nagy, P., Naidu, S., Nair, S., Nakano, H., Nakatogawa, H., Nanjundan, M., Napolitano, G., Naqvi, N., Nardacci, R., Narendra, D., Narita, M., Nascimbeni, A., Natarajan, R., Navegantes, L., Nawrocki, S., Nazarko, T., Nazarko, V., Neill, T., Neri, L., Netea, M., Netea-Maier, R., Neves, B., Ney, P., Nezis, I., Nguyen, H., Nicot, A., Nilsen, H., Nilsson, P., Nishimura, M., Nishino, I., Niso-Santano, M., Niu, H., Nixon, R., Njar, V., Noda, T., Noegel, A., Nolte, E., Norberg, E., Norga, K., Noureini, S., Notomi, S., Notterpek, L., Nowikovsky, K., Nukina, N., Nürnberger, T., O'Donnell, V., O'Donovan, T., O'Dwyer, P., Oehme, I., Oeste, C., Ogawa, M., Ogretmen, B., Ogura, Y., Oh, Y., Ohmuraya, M., Ohshima, T., Ojha, R., Okamoto, K., Okazaki, T., Oliver, F., Ollinger, K., Olsson, S., Orban, D., Ordonez, P., Orhon, I., Orosz, L., O'Rourke, E., Orozco, H., Ortega, A., Ortona, E., Osellame, L., Oshima, J., Oshima, S., Osiewacz, H., Otomo, T., Otsu, K., Ou, J., Outeiro, T., Ouyang, D., Ouyang, H., Overholtzer, M., Ozbun, M., Ozdinler, P., Ozpolat, B., Pacelli, C., Paganetti, P., Page, G., Pages, G., Pagnini, U., Pajak, B., Pak, S., Pakos-Zebrucka, K., Pakpour, N., Palková, Z., Palladino, F., Pallauf, K., Pallet, N., Palmieri, M., Paludan, S., Palumbo, C., Palumbo, S., Pampliega, O., Pan, H., Pan, W., Panaretakis, T., Pandey, A., Pantazopoulou, A., Papackova, Z., Papademetrio, D., Papassideri, I., Papini, A., Parajuli, N., Pardo, J., Parekh, V., Parenti, G., Park, J., Park, O., Parker, R., Parlato, R., Parys, J., Parzych, K., Pasquet, J., Pasquier, B., Pasumarthi, K., Patschan, D., Patterson, C., Pattingre, S., Pattison, S., Pause, A., Pavenstädt, H., Pavone, F., Pedrozo, Z., Peña, F., Peñalva, M., Pende, M., Peng, J., Penna, F., Penninger, J., Pensalfini, A., Pepe, S., Pereira, G., Pereira, P., Pérez-de la Cruz, V., Pérez-Pérez, M., Pérez-Rodríguez, D., Pérez-Sala, D., Perier, C., Perl, A., Perlmutter, D., Perrotta, I., Pervaiz, S., Pesonen, M., Pessin, J., Peters, G., Petersen, M., Petrache, I., Petrof, B., Petrovski, G., Phang, J., Piacentini, M., Pierdominici, M., Pierre, P., Pierrefite-Carle, V., Pietrocola, F., Pimentel-Muiños, F., Pinar, M., Pineda, B., Pinkas-Kramarski, R., Pinti, M., Pinton, P., Piperdi, B., Piret, J., Platanias, L., Platta, H., Plowey, E., Pöggeler, S., Poirot, M., Polčic, P., Poletti, A., Poon, A., Popelka, H., Popova, B., Poprawa, I., Poulose, S., Poulton, J., Powers, S., Powers, T., Pozuelo-Rubio, M., Prak, K., Prange, R., Prescott, M., Priault, M., Prince, S., Proia, R., Proikas-Cezanne, T., Prokisch, H., Promponas, V., Przyklenk, K., Puertollano, R., Pugazhenthi, S., Puglielli, L., Pujol, A., Puyal, J., Pyeon, D., Qi, X., Qian, W., Qin, Z., Qiu, Y., Qu, Z., Quadrilatero, J., Quinn, F., Raben, N., Rabinowich, H., Radogna, F., Ragusa, M., Rahmani, M., Raina, K., Ramanadham, S., Ramesh, R., Rami, A., Randall-Demllo, S., Randow, F., Rao, H., Rao, V., Rasmussen, B., Rasse, T., Ratovitski, E., Rautou, P., Ray, S., Razani, B., Reed, B., Reggiori, F., Rehm, M., Reichert, A., Rein, T., Reiner, D., Reits, E., Ren, J., Ren, X., Renna, M., Reusch, J., Revuelta, J., Reyes, L., Rezaie, A., Richards, R., Richardson, D., Richetta, C., Riehle, M., Rihn, B., Rikihisa, Y., Riley, B., Rimbach, G., Rippo, M., Ritis, K., Rizzi, F., Rizzo, E., Roach, P., Robbins, J., Roberge, M., Roca, G., Roccheri, M., Rocha, S., Rodrigues, C., Rodríguez, C., de Cordoba, S., Rodriguez-Muela, N., Roelofs, J., Rogov, V., Rohn, T., Rohrer, B., Romanelli, D., Romani, L., Romano, P., Roncero, M., Rosa, J., Rosello, A., Rosen, K., Rosenstiel, P., Rost-Roszkowska, M., Roth, K., Roué, G., Rouis, M., Rouschop, K., Ruan, D., Ruano, D., Rubinsztein, D., Rucker, E., Rudich, A., Rudolf, E., Rudolf, R., Ruegg, M., Ruiz-Roldan, C., Ruparelia, A., Rusmini, P., Russ, D., Russo, G., Russo, R., Rusten, T., Ryabovol, V., Ryan, K., Ryter, S., Sabatini, D., Sacher, M., Sachse, C., Sack, M., Sadoshima, J., Saftig, P., Sagi-Eisenberg, R., Sahni, S., Saikumar, P., Saito, T., Saitoh, T., Sakakura, K., Sakoh-Nakatogawa, M., Sakuraba, Y., Salazar-Roa, M., Salomoni, P., Saluja, A., Salvaterra, P., Salvioli, R., Samali, A., Sanchez, A., Sánchez-Alcázar, J., Sanchez-Prieto, R., Sandri, M., Sanjuan, M., Santaguida, S., Santambrogio, L., Santoni, G., Dos Santos, C., Saran, S., Sardiello, M., Sargent, G., Sarkar, P., Sarkar, S., Sarrias, M., Sarwal, M., Sasakawa, C., Sasaki, M., Sass, M., Sato, K., Sato, M., Satriano, J., Savaraj, N., Saveljeva, S., Schaefer, L., Schaible, U., Scharl, M., Schatzl, H., Schekman, R., Scheper, W., Schiavi, A., Schipper, H., Schmeisser, H., Schmidt, J., Schmitz, I., Schneider, B., Schneider, E., Schneider, J., Schon, E., Schönenberger, M., Schönthal, A., Schorderet, D., Schröder, B., Schuck, S., Schulze, R., Schwarten, M., Schwarz, T., Sciarretta, S., Scotto, K., Scovassi, A., Screaton, R., Screen, M., Seca, H., Sedej, S., Segatori, L., Segev, N., Seglen, P., Seguí-Simarro, J., Segura-Aguilar, J., Seki, E., Sell, C., Selliez, I., Semenkovich, C., Semenza, G., Sen, U., Serra, A., Serrano-Puebla, A., Sesaki, H., Setoguchi, T., Settembre, C., Shacka, J., Shajahan-Haq, A., Shapiro, I., Sharma, S., She, H., Shen, C., Shen, H., Shen, S., Shen, W., Sheng, R., Sheng, X., Sheng, Z., Shepherd, T., Shi, J., Shi, Q., Shi, Y., Shibutani, S., Shibuya, K., Shidoji, Y., Shieh, J., Shih, C., Shimada, Y., Shimizu, S., Shin, D., Shinohara, M., Shintani, M., Shintani, T., Shioi, T., Shirabe, K., Shiri-Sverdlov, R., Shirihai, O., Shore, G., Shu, C., Shukla, D., Sibirny, A., Sica, V., Sigurdson, C., Sigurdsson, E., Sijwali, P., Sikorska, B., Silveira, W., Silvente-Poirot, S., Silverman, G., Simak, J., Simmet, T., Simon, A., Simon, H., Simone, C., Simons, M., Simonsen, A., Singh, R., Singh, S., Sinha, D., Sinha, S., Sinicrope, F., Sirko, A., Sirohi, K., Sishi, B., Sittler, A., Siu, P., Sivridis, E., Skwarska, A., Slack, R., Slaninová, I., Slavov, N., Smaili, S., Smalley, K., Smith, D., Soenen, S., Soleimanpour, S., Solhaug, A., Somasundaram, K., Son, J., Sonawane, A., Song, C., Song, F., Song, H., Song, J., Song, W., Soo, K., Sood, A., Soong, T., Soontornniyomkij, V., Sorice, M., Sotgia, F., Soto-Pantoja, D., Sotthibundhu, A., Sousa, M., Spaink, H., Span, P., Spang, A., Sparks, J., Speck, P., Spector, S., Spies, C., Springer, W., Clair, D., Stacchiotti, A., Staels, B., Stang, M., Starczynowski, D., Starokadomskyy, P., Steegborn, C., Steele, J., Stefanis, L., Steffan, J., Stellrecht, C., Stenmark, H., Stepkowski, T., Stern, S., Stevens, C., Stockwell, B., Stoka, V., Storchova, Z., Stork, B., Stratoulias, V., Stravopodis, D., Strnad, P., Strohecker, A., Ström, A., Stromhaug, P., Stulik, J., Su, Y., Su, Z., Subauste, C., Subramaniam, S., Sue, C., Suh, S., Sui, X., Sukseree, S., Sulzer, D., Sun, F., Sun, J., Sun, S., Sun, Y., Sundaramoorthy, V., Sung, J., Suzuki, H., Suzuki, K., Suzuki, N., Suzuki, T., Suzuki, Y., Swanson, M., Swanton, C., Swärd, K., Swarup, G., Sweeney, S., Sylvester, P., Szatmari, Z., Szegezdi, E., Szlosarek, P., Taegtmeyer, H., Tafani, M., Taillebourg, E., Tait, S., Takacs-Vellai, K., Takahashi, Y., Takáts, S., Takemura, G., Takigawa, N., Talbot, N., Tamagno, E., Tamburini, J., Tan, C., Tan, L., Tan, M., Tan, Y., Tanaka, K., Tanaka, M., Tang, D., Tang, G., Tanida, I., Tanji, K., Tannous, B., Tapia, J., Tasset-Cuevas, I., Tatar, M., Tavassoly, I., Tavernarakis, N., Taylor, A., Taylor, G., Taylor, J., Taylor, M., Tchetina, E., Tee, A., Teixeira-Clerc, F., Telang, S., Tencomnao, T., Teng, B., Teng, R., Terro, F., Tettamanti, G., Theiss, A., Theron, A., Thomas, K., Thomé, M., Thomes, P., Thorburn, A., Thorner, J., Thum, T., Thumm, M., Thurston, T., Tian, L., Till, A., Ting, J., Titorenko, V., Toker, L., Toldo, S., Tooze, S., Topisirovic, I., Torgersen, M., Torosantucci, L., Torriglia, A., Torrisi, M., Tournier, C., Towns, R., Trajkovic, V., Travassos, L., Triola, G., Tripathi, D., Trisciuoglio, D., Troncoso, R., Trougakos, I., Truttmann, A., Tsai, K., Tschan, M., Tseng, Y., Tsukuba, T., Tsung, A., Tsvetkov, A., Tu, S., Tuan, H., Tucci, M., Tumbarello, D., Turk, B., Turk, V., Turner, R., Tveita, A., Tyagi, S., Ubukata, M., Uchiyama, Y., Udelnow, A., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Underwood, B., Ungermann, C., Ureshino, R., Ushioda, R., Uversky, V., Uzcátegui, N., Vaccari, T., Vaccaro, M., Váchová, L., Vakifahmetoglu-Norberg, H., Valdor, R., Valente, E., Vallette, F., Valverde, A., Van den Berghe, G., Van Den Bosch, L., van den Brink, G., van der Goot, F., van der Klei, I., van der Laan, L., van Doorn, W., van Egmond, M., van Golen, K., Van Kaer, L., van Lookeren Campagne, M., Vandenabeele, P., Vandenberghe, W., Vanhorebeek, I., Varela-Nieto, I., Vasconcelos, M., Vasko, R., Vavvas, D., Vega-Naredo, I., Velasco, G., Velentzas, A., Velentzas, P., Vellai, T., Vellenga, E., Vendelbo, M., Venkatachalam, K., Ventura, N., Ventura, S., Veras, P., Verdier, M., Vertessy, B., Viale, A., Vidal, M., Vieira, H., Vierstra, R., Vigneswaran, N., Vij, N., Vila, M., Villar, M., Villar, V., Villarroya, J., Vindis, C., Viola, G., Viscomi, M., Vitale, G., Vogl, D., Voitsekhovskaja, O., von Haefen, C., von Schwarzenberg, K., Voth, D., Vouret-Craviari, V., Vuori, K., Vyas, J., Waeber, C., Walker, C., Walker, M., Walter, J., Wan, L., Wan, X., Wang, B., Wang, C., Wang, D., Wang, F., Wang, G., Wang, H., Wang, J., Wang, M., Wang, P., Wang, R., Wang, S., Wang, T., Wang, X., Wang, Y., Wang, Z., Wappner, P., Ward, C., Ward, D., Warnes, G., Watada, H., Watanabe, Y., Watase, K., Weaver, T., Weekes, C., Wei, J., Weide, T., Weihl, C., Weindl, G., Weis, S., Wen, L., Wen, X., Wen, Y., Westermann, B., Weyand, C., White, A., White, E., Whitton, J., Whitworth, A., Wiels, J., Wild, F., Wildenberg, M., Wileman, T., Wilkinson, D., Wilkinson, S., Willbold, D., Williams, C., Williams, K., Williamson, P., Winklhofer, K., Witkin, S., Wohlgemuth, S., Wollert, T., Wolvetang, E., Wong, E., Wong, G., Wong, R., Wong, V., Woodcock, E., Wright, K., Wu, C., Wu, D., Wu, G., Wu, J., Wu, M., Wu, S., Wu, W., Wu, Y., Wu, Z., Xavier, C., Xavier, R., Xia, G., Xia, T., Xia, W., Xia, Y., Xiao, H., Xiao, J., Xiao, S., Xiao, W., Xie, C., Xie, Z., Xilouri, M., Xiong, Y., Xu, C., Xu, F., Xu, H., Xu, J., Xu, L., Xu, X., Xu, Y., Xu, Z., Xue, Y., Yamada, T., Yamamoto, A., Yamanaka, K., Yamashina, S., Yamashiro, S., Yan, B., Yan, X., Yan, Z., Yanagi, Y., Yang, D., Yang, J., Yang, L., Yang, M., Yang, P., Yang, Q., Yang, W., Yang, X., Yang, Y., Yang, Z., Yao, M., Yao, P., Yao, X., Yao, Z., Yasui, L., Ye, M., Yedvobnick, B., Yeganeh, B., Yeh, E., Yeyati, P., Yi, F., Yi, L., Yin, X., Yip, C., Yoo, Y., Yoon, S., Yoshida, K., Yoshimori, T., Young, K., Yu, H., Yu, J., Yu, L., Yu, W., Yu, X., Yu, Z., Yuan, J., Yuan, Z., Yue, B., Yue, J., Yue, Z., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zaglia, T., Zakeri, Z., Zecchini, V., Zeng, J., Zeng, M., Zeng, Q., Zervos, A., Zhang, D., Zhang, F., Zhang, G., Zhang, H., Zhang, J., Zhang, L., Zhang, M., Zhang, X., Zhang, Y., Zhao, M., Zhao, W., Zhao, X., Zhao, Y., Zhao, Z., Zheng, D., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, G., Zhou, H., Zhou, S., Zhou, X., Zhu, H., Zhu, W., Zhu, X., Zhu, Y., Zhuang, S., Zhuang, X., Ziparo, E., Zois, C., Zoladek, T., Zong, W., Zorzano, A., Zughaier, S., Klionsky, Daniel J, Abdelmohsen, Kotb, Abe, Akihisa, Abedin, Md Joynal, Abeliovich, Hagai, Acevedo Arozena, Abraham, Adachi, Hiroaki, Adams, Christopher M, Adams, Peter D, Adeli, Khosrow, Adhihetty, Peter J, Adler, Sharon G, Agam, Galila, Agarwal, Rajesh, Aghi, Manish K, Agnello, Maria, Agostinis, Patrizia, Aguilar, Patricia V, Aguirre Ghiso, Julio, Airoldi, Edoardo M, Ait Si Ali, Slimane, Akematsu, Takahiko, Akporiaye, Emmanuel T, Al Rubeai, Mohamed, Albaiceta, Guillermo M, Albanese, Chri, Albani, Diego, Albert, Matthew L, Aldudo, Jesu, Algül, Hana, Alirezaei, Mehrdad, Alloza, Iraide, Almasan, Alexandru, Almonte Beceril, Maylin, Alnemri, Emad S, Alonso, Covadonga, Altan Bonnet, Nihal, Altieri, Dario C, Alvarez, Silvia, Alvarez Erviti, Lydia, Alves, Sandro, Amadoro, Giuseppina, Amano, Atsuo, Amantini, Consuelo, Ambrosio, Santiago, Amelio, Ivano, Amer, Amal O, Amessou, Mohamed, Amon, Angelika, An, Zhenyi, Anania, Frank A, Andersen, Stig U, Andley, Usha P, Andreadi, Catherine K, Andrieu Abadie, Nathalie, Anel, Alberto, Ann, David K, Anoopkumar Dukie, Shailendra, Antonioli, Manuela, Aoki, Hiroshi, Apostolova, Nadezda, Aquila, Saveria, Aquilano, Katia, Araki, Koichi, Arama, Eli, Aranda, Agustin, Araya, Jun, Arcaro, Alexandre, Arias, Esperanza, Arimoto, Hirokazu, Ariosa, Aileen R, Armstrong, Jane L, Arnould, Thierry, Arsov, Ivica, Asanuma, Katsuhiko, Askanas, Valerie, Asselin, Eric, Atarashi, Ryuichiro, Atherton, Sally S, Atkin, Julie D, Attardi, Laura D, Auberger, Patrick, Auburger, Georg, Aurelian, Laure, Autelli, Riccardo, Avagliano, Laura, Avantaggiati, Maria Laura, Avrahami, Limor, Awale, Suresh, Azad, Neelam, Bachetti, Tiziana, Backer, Jonathan M, Bae, Dong Hun, Bae, Jae Sung, Bae, Ok Nam, Bae, Soo Han, Baehrecke, Eric H, Baek, Seung Hoon, Baghdiguian, Stephen, Bagniewska Zadworna, Agnieszka, Bai, Hua, Bai, Jie, Bai, Xue Yuan, Bailly, Yannick, Balaji, Kithiganahalli Narayanaswamy, Balduini, Walter, Ballabio, Andrea, Balzan, Rena, Banerjee, Rajkumar, Bánhegyi, Gábor, Bao, Haijun, Barbeau, Benoit, Barrachina, Maria D, Barreiro, Esther, Bartel, Bonnie, Bartolomé, Alberto, Bassham, Diane C, Bassi, Maria Teresa, Bast, Robert C, Basu, Alakananda, Batista, Maria Teresa, Batoko, Henri, Battino, Maurizio, Bauckman, Kyle, Baumgarner, Bradley L, Bayer, K. Ulrich, Beale, Rupert, Beaulieu, Jean Françoi, Beck, George R, Becker, Christoph, Beckham, J. David, Bédard, Pierre André, Bednarski, Patrick J, Begley, Thomas J, Behl, Christian, Behrends, Christian, Behrens, Georg Mn, Behrns, Kevin E, Bejarano, Eloy, Belaid, Amine, Belleudi, Francesca, Bénard, Giovanni, Berchem, Guy, Bergamaschi, Daniele, Bergami, Matteo, Berkhout, Ben, Berliocchi, Laura, Bernard, Amélie, Bernard, Monique, Bernassola, Francesca, Bertolotti, Anne, Bess, Amanda S, Besteiro, Sébastien, Bettuzzi, Saverio, Bhalla, Savita, Bhattacharyya, Shalmoli, Bhutia, Sujit K, Biagosch, Caroline, Bianchi, Michele Wolfe, Biard Piechaczyk, Martine, Billes, Viktor, Bincoletto, Claudia, Bingol, Bari, Bird, Sara W, Bitoun, Marc, Bjedov, Ivana, Blackstone, Craig, Blanc, Lionel, Blanco, Guillermo A, Blomhoff, Heidi Kiil, Boada Romero, Emilio, Böckler, Stefan, Boes, Marianne, Boesze Battaglia, Kathleen, Boise, Lawrence H, Bolino, Alessandra, Boman, Andrea, Bonaldo, Paolo, Bordi, Matteo, Bosch, Jürgen, Botana, Luis M, Botti, Joelle, Bou, German, Bouché, Marina, Bouchecareilh, Marion, Boucher, Marie Josée, Boulton, Michael E, Bouret, Sebastien G, Boya, Patricia, Boyer Guittaut, Michaël, Bozhkov, Peter V, Brady, Nathan, Braga, Vania Mm, Brancolini, Claudio, Braus, Gerhard H, Bravo San Pedro, José M, Brennan, Lisa A, Bresnick, Emery H, Brest, Patrick, Bridges, Dave, Bringer, Marie Agnè, Brini, Marisa, Brito, Glauber C, Brodin, Bertha, Brookes, Paul S, Brown, Eric J, Brown, Karen, Broxmeyer, Hal E, Bruhat, Alain, Brum, Patricia Chakur, Brumell, John H, BRUNETTI PIERRI, Nicola, Bryson Richardson, Robert J, Buch, Shilpa, Buchan, Alastair M, Budak, Hikmet, Bulavin, Dmitry V, Bultman, Scott J, Bultynck, Geert, Bumbasirevic, Vladimir, Burelle, Yan, Burke, Robert E, Burmeister, Margit, Bütikofer, Peter, Caberlotto, Laura, Cadwell, Ken, Cahova, Monika, Cai, Dongsheng, Cai, Jingjing, Cai, Qian, Calatayud, Sara, Camougrand, Nadine, Campanella, Michelangelo, Campbell, Grant R, Campbell, Matthew, Campello, Silvia, Candau, Robin, Caniggia, Isabella, Cantoni, Lavinia, Cao, Lizhi, Caplan, Allan B, Caraglia, Michele, Cardinali, Claudio, Cardoso, Sandra Morai, Carew, Jennifer S, Carleton, Laura A, Carlin, Cathleen R, Carloni, Silvia, Carlsson, Sven R, Carmona Gutierrez, Didac, Carneiro, Leticia Am, Carnevali, Oliana, Carra, Serena, Carrier, Alice, Carroll, Bernadette, Casas, Caty, Casas, Josefina, Cassinelli, Giuliana, Castets, Perrine, Castro Obregon, Susana, Cavallini, Gabriella, Ceccherini, Isabella, Cecconi, Francesco, Cederbaum, Arthur I, Ceña, Valentín, Cenci, Simone, Cerella, Claudia, Cervia, Davide, Cetrullo, Silvia, Chaachouay, Hassan, Chae, Han Jung, Chagin, Andrei S, Chai, Chee Yin, Chakrabarti, Gopal, Chamilos, Georgio, Chan, Edmond Yw, Chan, Matthew Tv, Chandra, Dhyan, Chandra, Pallavi, Chang, Chih Peng, Chang, Raymond Chuen Chung, Chang, Ta Yuan, Chatham, John C, Chatterjee, Saurabh, Chauhan, Santosh, Che, Yongsheng, Cheetham, Michael E, Cheluvappa, Rajkumar, Chen, Chun Jung, Chen, Gang, Chen, Guang Chao, Chen, Guoqiang, Chen, Hongzhuan, Chen, Jeff W, Chen, Jian Kang, Chen, Min, Chen, Mingzhou, Chen, Peiwen, Chen, Qi, Chen, Quan, Chen, Shang Der, Chen, Si, Chen, Steve S. L, Chen, Wei, Chen, Wei Jung, Chen, Wen Qiang, Chen, Wenli, Chen, Xiangmei, Chen, Yau Hung, Chen, Ye Guang, Chen, Yin, Chen, Yingyu, Chen, Yongshun, Chen, Yu Jen, Chen, Yue Qin, Chen, Yujie, Chen, Zhen, Chen, Zhong, Cheng, Alan, Cheng, Christopher Hk, Cheng, Hua, Cheong, Heesun, Cherry, Sara, Chesney, Jason, Cheung, Chun Hei Antonio, Chevet, Eric, Chi, Hsiang Cheng, Chi, Sung Gil, Chiacchiera, Fulvio, Chiang, Hui Ling, Chiarelli, Roberto, Chiariello, Mario, Chieppa, Marcello, Chin, Lih Shen, Chiong, Mario, Chiu, Gigi Nc, Cho, Dong Hyung, Cho, Ssang Goo, Cho, William C, Cho, Yong Yeon, Cho, Young Seok, Choi, Augustine Mk, Choi, Eui Ju, Choi, Eun Kyoung, Choi, Jayoung, Choi, Mary E, Choi, Seung Il, Chou, Tsui Fen, Chouaib, Salem, Choubey, Divaker, Choubey, Vinay, Chow, Kuan Chih, Chowdhury, Kamal, Chu, Charleen T, Chuang, Tsung Hsien, Chun, Taehoon, Chung, Hyewon, Chung, Taijoon, Chung, Yuen Li, Chwae, Yong Joon, Cianfanelli, Valentina, Ciarcia, Roberto, Ciechomska, Iwona A, Ciriolo, Maria Rosa, Cirone, Mara, Claerhout, Sofie, Clague, Michael J, Clària, Joan, Clarke, Peter Gh, Clarke, Robert, Clementi, Emilio, Cleyrat, Cédric, Cnop, Miriam, Coccia, Eliana M, Cocco, Tiziana, Codogno, Patrice, Coers, Jörn, Cohen, Ezra Ew, Colecchia, David, Coletto, Luisa, Coll, Núria S, Colucci Guyon, Emma, Comincini, Sergio, Condello, Maria, Cook, Katherine L, Coombs, Graham H, Cooper, Cynthia D, Cooper, J. Mark, Coppens, Isabelle, Corasaniti, Maria Tiziana, Corazzari, Marco, Corbalan, Ramon, Corcelle Termeau, Elisabeth, Cordero, Mario D, Corral Ramos, Cristina, Corti, Olga, Cossarizza, Andrea, Costelli, Paola, Costes, Safia, Cotman, Susan L, Coto Montes, Ana, Cottet, Sandra, Couve, Eduardo, Covey, Lori R, Cowart, L. Ashley, Cox, Jeffery S, Coxon, Fraser P, Coyne, Carolyn B, Cragg, Mark S, Craven, Rolf J, Crepaldi, Tiziana, Crespo, Jose L, Criollo, Alfredo, Crippa, Valeria, Cruz, Maria Teresa, Cuervo, Ana Maria, Cuezva, Jose M, Cui, Taixing, Cutillas, Pedro R, Czaja, Mark J, Czyzyk Krzeska, Maria F, Dagda, Ruben K, Dahmen, Uta, Dai, Chunsun, Dai, Wenjie, Dai, Yun, Dalby, Kevin N, Dalla Valle, Luisa, Dalmasso, Guillaume, D'Amelio, Marcello, Damme, Marku, Darfeuille Michaud, Arlette, Dargemont, Catherine, Darley Usmar, Victor M, Dasarathy, Srinivasan, Dasgupta, Biplab, Dash, Srikanta, Dass, Crispin R, Davey, Hazel Marie, Davids, Lester M, Dávila, David, Davis, Roger J, Dawson, Ted M, Dawson, Valina L, Daza, Paula, de Belleroche, Jackie, de Figueiredo, Paul, de Figueiredo, Regina Celia Bressan Queiroz, de la Fuente, José, DE MARTINO, Luisa, De Matteis, Antonella, De Meyer, Guido Ry, De Milito, Angelo, De Santi, Mauro, de Souza, Wanderley, De Tata, Vincenzo, De Zio, Daniela, Debnath, Jayanta, Dechant, Reinhard, Decuypere, Jean Paul, Deegan, Shane, Dehay, Benjamin, Del Bello, Barbara, Del Re, Dominic P, Delage Mourroux, Régi, Delbridge, Lea Md, Deldicque, Louise, Delorme Axford, Elizabeth, Deng, Yizhen, Dengjel, Joern, Denizot, Melanie, Dent, Paul, Der, Channing J, Deretic, Vojo, Derrien, Benoît, Deutsch, Eric, Devarenne, Timothy P, Devenish, Rodney J, Di Bartolomeo, Sabrina, Di Daniele, Nicola, Di Domenico, Fabio, Di Nardo, Alessia, Di Paola, Simone, Di Pietro, Antonio, Di Renzo, Livia, Diantonio, Aaron, Díaz Araya, Guillermo, Díaz Laviada, Ine, Diaz Meco, Maria T, Diaz Nido, Javier, Dickey, Chad A, Dickson, Robert C, Diederich, Marc, Digard, Paul, Dikic, Ivan, Dinesh Kumar, Savithrama P, Ding, Chan, Ding, Wen Xing, Ding, Zufeng, Dini, Luciana, Distler, Jörg Hw, Diwan, Abhinav, Djavaheri Mergny, Mojgan, Dmytruk, Kostyantyn, Dobson, Renwick Cj, Doetsch, Volker, Dokladny, Karol, Dokudovskaya, Svetlana, Donadelli, Massimo, Dong, X. Charlie, Dong, Xiaonan, Dong, Zheng, Donohue, Terrence M, Doran, Kelly S, D'Orazi, Gabriella, Dorn, Gerald W, Dosenko, Victor, Dridi, Sami, Drucker, Liat, Du, Jie, Du, Li Lin, Du, Lihuan, du Toit, André, Dua, Priyamvada, Duan, Lei, Duann, Pu, Dubey, Vikash Kumar, Duchen, Michael R, Duchosal, Michel A, Duez, Helene, Dugail, Isabelle, Dumit, Verónica I, Duncan, Mara C, Dunlop, Elaine A, Dunn, William A, Dupont, Nicola, Dupuis, Luc, Durán, Raúl V, Durcan, Thomas M, Duvezin Caubet, Stéphane, Duvvuri, Umamaheswar, Eapen, Vinay, Ebrahimi Fakhari, Dariu, Echard, Arnaud, Eckhart, Leopold, Edelstein, Charles L, Edinger, Aimee L, Eichinger, Ludwig, Eisenberg, Tobia, Eisenberg Lerner, Avital, Eissa, N. Tony, El Deiry, Wafik S, El Khoury, Victoria, Elazar, Zvulun, Eldar Finkelman, Hagit, Elliott, Chris Jh, Emanuele, Enzo, Emmenegger, Urban, Engedal, Nikolai, Engelbrecht, Anna Mart, Engelender, Simone, Enserink, Jorrit M, Erdmann, Ralf, Erenpreisa, Jekaterina, Eri, Rajaraman, Eriksen, Jason L, Erman, Andreja, Escalante, Ricardo, Eskelinen, Eeva Liisa, Espert, Lucile, Esteban Martínez, Lorena, Evans, Thomas J, Fabri, Mario, Fabrias, Gemma, Fabrizi, Cinzia, Facchiano, Antonio, Færgeman, Nils J, Faggioni, Alberto, Fairlie, W. Dougla, Fan, Chunhai, Fan, Daping, Fan, Jie, Fang, Shengyun, Fanto, Manoli, Fanzani, Alessandro, Farkas, Thoma, Faure, Mathia, Favier, Francois B, Fearnhead, Howard, Federici, Massimo, Fei, Erkang, Felizardo, Tania C, Feng, Hua, Feng, Yibin, Feng, Yuchen, Ferguson, Thomas A, Fernández, Álvaro F, Fernandez Barrena, Maite G, Fernandez Checa, Jose C, Fernández López, Arsenio, Fernandez Zapico, Martin E, Feron, Olivier, Ferraro, Elisabetta, Ferreira Halder, Carmen Veríssima, Fesus, Laszlo, Feuer, Ralph, Fiesel, Fabienne C, Filippi Chiela, Eduardo C, Filomeni, Giuseppe, Fimia, Gian Maria, Fingert, John H, Finkbeiner, Steven, Finkel, Toren, Fiorito, Filomena, Fisher, Paul B, Flajolet, Marc, Flamigni, Flavio, Florey, Oliver, Florio, Salvatore, Floto, R. Andre, Folini, Marco, Follo, Carlo, Fon, Edward A, Fornai, Francesco, Fortunato, Franco, Fraldi, Alessandro, Franco, Rodrigo, Francois, Arnaud, François, Aurélie, Frankel, Lisa B, Fraser, Iain Dc, Frey, Norbert, Freyssenet, Damien G, Frezza, Christian, Friedman, Scott L, Frigo, Daniel E, Fu, Dongxu, Fuentes, José M, Fueyo, Juan, Fujitani, Yoshio, Fujiwara, Yuuki, Fujiya, Mikihiro, Fukuda, Mitsunori, Fulda, Simone, Fusco, Carmela, Gabryel, Bozena, Gaestel, Matthia, Gailly, Philippe, Gajewska, Malgorzata, Galadari, Sehamuddin, Galili, Gad, Galindo, Inmaculada, Galindo, Maria F, Galliciotti, Giovanna, Galluzzi, Lorenzo, Galluzzi, Luca, Galy, Vincent, Gammoh, Noor, Gandy, Sam, Ganesan, Anand K, Ganesan, Swamynathan, Ganley, Ian G, Gannagé, Monique, Gao, Fen Biao, Gao, Feng, Gao, Jian Xin, García Nannig, Lorena, García Véscovi, Eleonora, Garcia Macía, Marina, Garcia Ruiz, Carmen, Garg, Abhishek D, Garg, Pramod Kumar, Gargini, Ricardo, Gassen, Nils Christian, Gatica, Damián, Gatti, Evelina, Gavard, Julie, Gavathiotis, Evripidi, Ge, Liang, Ge, Pengfei, Ge, Shengfang, Gean, Po Wu, Gelmetti, Vania, Genazzani, Armando A, Geng, Jiefei, Genschik, Pascal, Gerner, Lisa, Gestwicki, Jason E, Gewirtz, David A, Ghavami, Saeid, Ghigo, Eric, Ghosh, Debabrata, Giammarioli, Anna Maria, Giampieri, Francesca, Giampietri, Claudia, Giatromanolaki, Alexandra, Gibbings, Derrick J, Gibellini, Lara, Gibson, Spencer B, Ginet, Vanessa, Giordano, Antonio, Giorgini, Flaviano, Giovannetti, Elisa, Girardin, Stephen E, Gispert, Suzana, Giuliano, Sandy, Gladson, Candece L, Glavic, Alvaro, Gleave, Martin, Godefroy, Nelly, Gogal, Robert M, Gokulan, Kuppan, Goldman, Gustavo H, Goletti, Delia, Goligorsky, Michael S, Gomes, Aldrin V, Gomes, Ligia C, Gomez, Hernando, Gomez Manzano, Candelaria, Gómez Sánchez, Rubén, Gonçalves, Dawit Ap, Goncu, Ebru, Gong, Qingqiu, Gongora, Céline, Gonzalez, Carlos B, Gonzalez Alegre, Pedro, Gonzalez Cabo, Pilar, González Polo, Rosa Ana, Goping, Ing Swie, Gorbea, Carlo, Gorbunov, Nikolai V, Goring, Daphne R, Gorman, Adrienne M, Gorski, Sharon M, Goruppi, Sandro, Goto Yamada, Shino, Gotor, Cecilia, Gottlieb, Roberta A, Gozes, Illana, Gozuacik, Devrim, Graba, Yacine, Graef, Martin, Granato, Giovanna E, Grant, Gary Dean, Grant, Steven, Gravina, Giovanni Luca, Green, Douglas R, Greenhough, Alexander, Greenwood, Michael T, Grimaldi, Benedetto, Gros, Frédéric, Grose, Charle, Groulx, Jean Francoi, Gruber, Florian, Grumati, Paolo, Grune, Tilman, Guan, Jun Lin, Guan, Kun Liang, Guerra, Barbara, Guillen, Carlo, Gulshan, Kailash, Gunst, Jan, Guo, Chuanyong, Guo, Lei, Guo, Ming, Guo, Wenjie, Guo, Xu Guang, Gust, Andrea A, Gustafsson, Åsa B, Gutierrez, Elaine, Gutierrez, Maximiliano G, Gwak, Ho Shin, Haas, Albert, Haber, James E, Hadano, Shinji, Hagedorn, Monica, Hahn, David R, Halayko, Andrew J, Hamacher Brady, Anne, Hamada, Kozo, Hamai, Ahmed, Hamann, Andrea, Hamasaki, Maho, Hamer, Isabelle, Hamid, Qutayba, Hammond, Ester M, Han, Feng, Han, Weidong, Handa, James T, Hanover, John A, Hansen, Malene, Harada, Masaru, Harhaji Trajkovic, Ljubica, Harper, J. Wade, Harrath, Abdel Halim, Harris, Adrian L, Harris, Jame, Hasler, Udo, Hasselblatt, Peter, Hasui, Kazuhisa, Hawley, Robert G, Hawley, Teresa S, He, Congcong, He, Cynthia Y, He, Fengtian, He, Gu, He, Rong Rong, He, Xian Hui, He, You Wen, He, Yu Ying, Heath, Joan K, Hébert, Marie Josée, Heinzen, Robert A, Helgason, Gudmundur Vignir, Hensel, Michael, Henske, Elizabeth P, Her, Chengtao, Herman, Paul K, Hernández, Agustín, Hernandez, Carlo, Hernández Tiedra, Sonia, Hetz, Claudio, Hiesinger, P. Robin, Higaki, Katsumi, Hilfiker, Sabine, Hill, Bradford G, Hill, Joseph A, Hill, William D, Hino, Keisuke, Hofius, Daniel, Hofman, Paul, Höglinger, Günter U, Höhfeld, Jörg, Holz, Marina K, Hong, Yonggeun, Hood, David A, Hoozemans, Jeroen Jm, Hoppe, Thorsten, Hsu, Chin, Hsu, Chin Yuan, Hsu, Li Chung, Hu, Dong, Hu, Guochang, Hu, Hong Ming, Hu, Hongbo, Hu, Ming Chang, Hu, Yu Chen, Hu, Zhuo Wei, Hua, Fang, Hua, Ya, Huang, Canhua, Huang, Huey Lan, Huang, Kuo How, Huang, Kuo Yang, Huang, Shile, Huang, Shiqian, Huang, Wei Pang, Huang, Yi Ran, Huang, Yong, Huang, Yunfei, Huber, Tobias B, Huebbe, Patricia, Huh, Won Ki, Hulmi, Juha J, Hur, Gang Min, Hurley, James H, Husak, Zvenyslava, Hussain, Sabah Na, Hussain, Salik, Hwang, Jung Jin, Hwang, Seungmin, Hwang, Thomas I, Ichihara, Atsuhiro, Imai, Yuzuru, Imbriano, Carol, Inomata, Megumi, Into, Takeshi, Iovane, Valentina, Iovanna, Juan L, Iozzo, Renato V, Ip, Nancy Y, Irazoqui, Javier E, Iribarren, Pablo, Isaka, Yoshitaka, Isakovic, Aleksandra J, Ischiropoulos, Harry, Isenberg, Jeffrey S, Ishaq, Mohammad, Ishida, Hiroyuki, Ishii, Isao, Ishmael, Jane E, Isidoro, Ciro, Isobe, Ken Ichi, Isono, Erika, Issazadeh Navikas, Shohreh, Itahana, Koji, Itakura, Eisuke, Ivanov, Andrei I, Iyer, Anand Krishnan V, Izquierdo, José M, Izumi, Yotaro, Izzo, Valentina, Jäättelä, Marja, Jaber, Nadia, Jackson, Daniel John, Jackson, William T, Jacob, Tony George, Jacques, Thomas S, Jagannath, Chinnaswamy, Jain, Ashish, Jana, Nihar Ranjan, Jang, Byoung Kuk, Jani, Alkesh, Janji, Bassam, Jannig, Paulo Roberto, Jansson, Patric J, Jean, Steve, Jendrach, Marina, Jeon, Ju Hong, Jessen, Niel, Jeung, Eui Bae, Jia, Kailiang, Jia, Lijun, Jiang, Hong, Jiang, Hongchi, Jiang, Liwen, Jiang, Teng, Jiang, Xiaoyan, Jiang, Xuejun, Jiang, Ying, Jiang, Yongjun, Jiménez, Alberto, Jin, Cheng, Jin, Hongchuan, Jin, Lei, Jin, Meiyan, Jin, Shengkan, Jinwal, Umesh Kumar, Jo, Eun Kyeong, Johansen, Terje, Johnson, Daniel E, Johnson, Gail Vw, Johnson, James D, Jonasch, Eric, Jones, Chri, Joosten, Leo Ab, Jordan, Joaquin, Joseph, Anna Maria, Joseph, Bertrand, Joubert, Annie M, Ju, Dianwen, Ju, Jingfang, Juan, Hsueh Fen, Juenemann, Katrin, Juhász, Gábor, Jung, Hye Seung, Jung, Jae U, Jung, Yong Keun, Jungbluth, Heinz, Justice, Matthew J, Jutten, Barry, Kaakoush, Nadeem O, Kaarniranta, Kai, Kaasik, Allen, Kabuta, Tomohiro, Kaeffer, Bertrand, Kågedal, Katarina, Kahana, Alon, Kajimura, Shingo, Kakhlon, Or, Kalia, Manjula, Kalvakolanu, Dhan V, Kamada, Yoshiaki, Kambas, Konstantino, Kaminskyy, Vitaliy O, Kampinga, Harm H, Kandouz, Mustapha, Kang, Chanhee, Kang, Rui, Kang, Tae Cheon, Kanki, Tomotake, Kanneganti, Thirumala Devi, Kanno, Haruo, Kanthasamy, Anumantha G, Kantorow, Marc, Kaparakis Liaskos, Maria, Kapuy, Orsolya, Karantza, Vassiliki, Karim, Md Razaul, Karmakar, Parimal, Kaser, Arthur, Kaushik, Susmita, Kawula, Thoma, Kaynar, A. Murat, Ke, Po Yuan, Ke, Zun Ji, Kehrl, John H, Keller, Kate E, Kemper, Jongsook Kim, Kenworthy, Anne K, Kepp, Oliver, Kern, Andrea, Kesari, Santosh, Kessel, David, Ketteler, Robin, Kettelhut, Isis do Carmo, Khambu, Bilon, Khan, Muzamil Majid, Khandelwal, Vinoth Km, Khare, Sangeeta, Kiang, Juliann G, Kiger, Amy A, Kihara, Akio, Kim, Arianna L, Kim, Cheol Hyeon, Kim, Deok Ryong, Kim, Do Hyung, Kim, Eung Kweon, Kim, Hye Young, Kim, Hyung Ryong, Kim, Jae Sung, Kim, Jeong Hun, Kim, Jin Cheon, Kim, Jin Hyoung, Kim, Kwang Woon, Kim, Michael D, Kim, Moon Moo, Kim, Peter K, Kim, Seong Who, Kim, Soo Youl, Kim, Yong Sun, Kim, Yonghyun, Kimchi, Adi, Kimmelman, Alec C, Kimura, Tomonori, King, Jason S, Kirkegaard, Karla, Kirkin, Vladimir, Kirshenbaum, Lorrie A, Kishi, Shuji, Kitajima, Yasuo, Kitamoto, Katsuhiko, Kitaoka, Yasushi, Kitazato, Kaio, Kley, Rudolf A, Klimecki, Walter T, Klinkenberg, Michael, Klucken, Jochen, Knævelsrud, Helene, Knecht, Erwin, Knuppertz, Laura, Ko, Jiunn Liang, Kobayashi, Satoru, Koch, Jan C, Koechlin Ramonatxo, Christelle, Koenig, Ulrich, Koh, Young Ho, Köhler, Katja, Kohlwein, Sepp D, Koike, Masato, Komatsu, Masaaki, Kominami, Eiki, Kong, Dexin, Kong, Hee Jeong, Konstantakou, Eumorphia G, Kopp, Benjamin T, Korcsmaros, Tama, Korhonen, Laura, Korolchuk, Viktor I, Koshkina, Nadya V, Kou, Yanjun, Koukourakis, Michael I, Koumenis, Constantino, Kovács, Attila L, Kovács, Tibor, Kovacs, Werner J, Koya, Daisuke, Kraft, Claudine, Krainc, Dimitri, Kramer, Helmut, Kravic Stevovic, Tamara, Krek, Wilhelm, Kretz Remy, Carole, Krick, Roswitha, Krishnamurthy, Malathi, Kriston Vizi, Jano, Kroemer, Guido, Kruer, Michael C, Kruger, Rejko, Ktistakis, Nicholas T, Kuchitsu, Kazuyuki, Kuhn, Christian, Kumar, Addanki Pratap, Kumar, Anuj, Kumar, Ashok, Kumar, Deepak, Kumar, Dhiraj, Kumar, Rakesh, Kumar, Sharad, Kundu, Mondira, Kung, Hsing Jien, Kuno, Atsushi, Kuo, Sheng Han, Kuret, Jeff, Kurz, Tino, Kwok, Terry, Kwon, Taeg Kyu, Kwon, Yong Tae, Kyrmizi, Irene, La Spada, Albert R, Lafont, Frank, Lahm, Tim, Lakkaraju, Aparna, Lam, Truong, Lamark, Trond, Lancel, Steve, Landowski, Terry H, Lane, Darius J. R, Lane, Jon D, Lanzi, Cinzia, Lapaquette, Pierre, Lapierre, Louis R, Laporte, Jocelyn, Laukkarinen, Johanna, Laurie, Gordon W, Lavandero, Sergio, Lavie, Lena, Lavoie, Matthew J, Law, Betty Yuen Kwan, Law, Helen Ka Wai, Law, Kelsey B, Layfield, Robert, Lazo, Pedro A, Le Cam, Laurent, Le Roch, Karine G, Le Stunff, Hervé, Leardkamolkarn, Vijittra, Lecuit, Marc, Lee, Byung Hoon, Lee, Che Hsin, Lee, Erinna F, Lee, Gyun Min, Lee, He Jin, Lee, Hsinyu, Lee, Jae Keun, Lee, Jongdae, Lee, Ju Hyun, Lee, Jun Hee, Lee, Michael, Lee, Myung Shik, Lee, Patty J, Lee, Sam W, Lee, Seung Jae, Lee, Shiow Ju, Lee, Stella Y, Lee, Sug Hyung, Lee, Sung Sik, Lee, Sung Joon, Lee, Sunhee, Lee, Ying Ray, Lee, Yong J, Lee, Young H, Leeuwenburgh, Christiaan, Lefort, Sylvain, Legouis, Renaud, Lei, Jinzhi, Lei, Qun Ying, Leib, David A, Leibowitz, Gil, Lekli, Istvan, Lemaire, Stéphane D, Lemasters, John J, Lemberg, Marius K, Lemoine, Antoinette, Leng, Shuilong, Lenz, Guido, Lenzi, Paola, Lerman, Lilach O, Lettieri Barbato, Daniele, Leu, Julia I. Ju, Leung, Hing Y, Levine, Beth, Lewis, Patrick A, Lezoualc'H, Frank, Li, Chi, Li, Faqiang, Li, Feng Jun, Li, Jun, Li, Ke, Li, Lian, Li, Min, Li, Qiang, Li, Rui, Li, Sheng, Li, Wei, Li, Xiaotao, Li, Yumin, Lian, Jiqin, Liang, Chengyu, Liang, Qiangrong, Liao, Yulin, Liberal, Joana, Liberski, Pawel P, Lie, Pearl, Lieberman, Andrew P, Lim, Hyunjung Jade, Lim, Kah Leong, Lim, Kyu, Lima, Raquel T, Lin, Chang Shen, Lin, Chiou Feng, Lin, Fang, Lin, Fangming, Lin, Fu Cheng, Lin, Kui, Lin, Kwang Huei, Lin, Pei Hui, Lin, Tianwei, Lin, Wan Wan, Lin, Yee Shin, Lin, Yong, Linden, Rafael, Lindholm, Dan, Lindqvist, Lisa M, Lingor, Paul, Linkermann, Andrea, Liotta, Lance A, Lipinski, Marta M, Lira, Vitor A, Lisanti, Michael P, Liton, Paloma B, Liu, Bo, Liu, Chong, Liu, Chun Feng, Liu, Fei, Liu, Hung Jen, Liu, Jianxun, Liu, Jing Jing, Liu, Jing Lan, Liu, Ke, Liu, Leyuan, Liu, Liang, Liu, Quentin, Liu, Rong Yu, Liu, Shiming, Liu, Shuwen, Liu, Wei, Liu, Xian De, Liu, Xiangguo, Liu, Xiao Hong, Liu, Xinfeng, Liu, Xu, Liu, Xueqin, Liu, Yang, Liu, Yule, Liu, Zexian, Liu, Zhe, Liuzzi, Juan P, Lizard, Gérard, Ljujic, Mila, Lodhi, Irfan J, Logue, Susan E, Lokeshwar, Bal L, Long, Yun Chau, Lonial, Sagar, Loos, Benjamin, López Otín, Carlo, López Vicario, Cristina, Lorente, Mar, Lorenzi, Philip L, Lõrincz, Péter, Los, Marek, Lotze, Michael T, Lovat, Penny E, Lu, Binfeng, Lu, Bo, Lu, Jiahong, Lu, Qing, Lu, She Min, Lu, Shuyan, Lu, Yingying, Luciano, Frédéric, Luckhart, Shirley, Lucocq, John Milton, Ludovico, Paula, Lugea, Aurelia, Lukacs, Nicholas W, Lum, Julian J, Lund, Anders H, Luo, Honglin, Luo, Jia, Luo, Shouqing, Luparello, Claudio, Lyons, Timothy, Ma, Jianjie, Ma, Yi, Ma, Yong, Ma, Zhenyi, Machado, Juliano, Machado Santelli, Glaucia M, Macian, Fernando, Macintosh, Gustavo C, Mackeigan, Jeffrey P, Macleod, Kay F, Macmicking, John D, MacMillan Crow, Lee Ann, Madeo, Frank, Madesh, Muniswamy, Madrigal Matute, Julio, Maeda, Akiko, Maeda, Tatsuya, Maegawa, Gustavo, Maellaro, Emilia, Maes, Hannelore, Magariños, Marta, Maiese, Kenneth, Maiti, Tapas K, Maiuri, Luigi, Maiuri, MARIA CHIARA, Maki, Carl G, Malli, Roland, Malorni, Walter, Maloyan, Alina, Mami Chouaib, Fathia, Man, Na, Mancias, Joseph D, Mandelkow, Eva Maria, Mandell, Michael A, Manfredi, Angelo A, Manié, Serge N, Manzoni, Claudia, Mao, Kai, Mao, Zixu, Mao, Zong Wan, Marambaud, Philippe, Marconi, Anna Maria, Marelja, Zvonimir, Marfe, Gabriella, Margeta, Marta, Margittai, Eva, Mari, Muriel, Mariani, Francesca V, Marin, Concepcio, Marinelli, Sara, Mariño, Guillermo, Markovic, Ivanka, Marquez, Rebecca, Martelli, Alberto M, Martens, Sascha, Martin, Katie R, Martin, Seamus J, Martin, Shaun, Martin Acebes, Miguel A, Martín Sanz, Paloma, Martinand Mari, Camille, Martinet, Wim, Martinez, Jennifer, Martinez Lopez, Nuria, Martinez Outschoorn, Ubaldo, Martínez Velázquez, Moisé, Martinez Vicente, Marta, Martins, Waleska Kerllen, Mashima, Hirosato, Mastrianni, James A, Matarese, Giuseppe, Matarrese, Paola, Mateo, Roberto, Matoba, Satoaki, Matsumoto, Naomichi, Matsushita, Takehiko, Matsuura, Akira, Matsuzawa, Takeshi, Mattson, Mark P, Matus, Soledad, Maugeri, Norma, Mauvezin, Caroline, Mayer, Andrea, Maysinger, Dusica, Mazzolini, Guillermo D, Mcbrayer, Mary Kate, Mccall, Kimberly, Mccormick, Craig, Mcinerney, Gerald M, Mciver, Skye C, Mckenna, Sharon, Mcmahon, John J, Mcneish, Iain A, Mechta Grigoriou, Fatima, Medema, Jan Paul, Medina, Diego L, Megyeri, Klara, Mehrpour, Maryam, Mehta, Jawahar L, Mei, Yide, Meier, Ute Christiane, Meijer, Alfred J, Meléndez, Alicia, Melino, Gerry, Melino, Sonia, de Melo, Edesio Jose Tenorio, Mena, Maria A, Meneghini, Marc D, Menendez, Javier A, Menezes, Regina, Meng, Liesu, Meng, Ling Hua, Meng, Songshu, Menghini, Rossella, Menko, A. Sue, Menna Barreto, Rubem F, Menon, Manoj B, Meraz Ríos, Marco A, Merla, Giuseppe, Merlini, Luciano, Merlot, Angelica M, Meryk, Andrea, Meschini, Stefania, Meyer, Joel N, Mi, Man Tian, Miao, Chao Yu, Micale, Lucia, Michaeli, Simon, Michiels, Carine, Migliaccio, Anna Rita, Mihailidou, Anastasia Susie, Mijaljica, Dalibor, Mikoshiba, Katsuhiko, Milan, Enrico, Miller Fleming, Leonor, Mills, Gordon B, Mills, Ian G, Minakaki, Georgia, Minassian, Berge A, Ming, Xiu Fen, Minibayeva, Farida, Minina, Elena A, Mintern, Justine D, Minucci, Saverio, Miranda Vizuete, Antonio, Mitchell, Claire H, Miyamoto, Shigeki, Miyazawa, Keisuke, Mizushima, Noboru, Mnich, Katarzyna, Mograbi, Baharia, Mohseni, Simin, Moita, Luis Ferreira, Molinari, Marco, Molinari, Maurizio, Møller, Andreas Buch, Mollereau, Bertrand, Mollinedo, Faustino, Mongillo, Marco, Monick, Martha M, Montagnaro, Serena, Montell, Craig, Moore, Darren J, Moore, Michael N, Mora Rodriguez, Rodrigo, Moreira, Paula I, Morel, Etienne, Morelli, Maria Beatrice, Moreno, Sandra, Morgan, Michael J, Moris, Arnaud, Moriyasu, Yuji, Morrison, Janna L, Morrison, Lynda A, Morselli, Eugenia, Moscat, Jorge, Moseley, Pope L, Mostowy, Serge, Motori, Elisa, Mottet, Deni, Mottram, Jeremy C, Moussa, Charbel E. H, Mpakou, Vassiliki E, Mukhtar, Hasan, Mulcahy Levy, Jean M, Muller, Sylviane, Muñoz Moreno, Raquel, Muñoz Pinedo, Cristina, Münz, Christian, Murphy, Maureen E, Murray, James T, Murthy, Aditya, Mysorekar, Indira U, Nabi, Ivan R, Nabissi, Massimo, Nader, Gustavo A, Nagahara, Yukitoshi, Nagai, Yoshitaka, Nagata, Kazuhiro, Nagelkerke, Anika, Nagy, Péter, Naidu, Samisubbu R, Nair, Sreejayan, Nakano, Hiroyasu, Nakatogawa, Hitoshi, Nanjundan, Meera, Napolitano, Gennaro, Naqvi, Naweed I, Nardacci, Roberta, Narendra, Derek P, Narita, Masashi, Nascimbeni, Anna Chiara, Natarajan, Ramesh, Navegantes, Luiz C, Nawrocki, Steffan T, Nazarko, Taras Y, Nazarko, Volodymyr Y, Neill, Thoma, Neri, Luca M, Netea, Mihai G, Netea Maier, Romana T, Neves, Bruno M, Ney, Paul A, Nezis, Ioannis P, Nguyen, Hang Tt, Nguyen, Huu Phuc, Nicot, Anne Sophie, Nilsen, Hilde, Nilsson, Per, Nishimura, Mikio, Nishino, Ichizo, Niso Santano, Mireia, Niu, Hua, Nixon, Ralph A, Njar, Vincent Co, Noda, Takeshi, Noegel, Angelika A, Nolte, Elsie Magdalena, Norberg, Erik, Norga, Koenraad K, Noureini, Sakineh Kazemi, Notomi, Shoji, Notterpek, Lucia, Nowikovsky, Karin, Nukina, Nobuyuki, Nürnberger, Thorsten, O'Donnell, Valerie B, O'Donovan, Tracey, O'Dwyer, Peter J, Oehme, Ina, Oeste, Clara L, Ogawa, Michinaga, Ogretmen, Besim, Ogura, Yuji, Oh, Young J, Ohmuraya, Masaki, Ohshima, Takayuki, Ojha, Rani, Okamoto, Koji, Okazaki, Toshiro, Oliver, F. Javier, Ollinger, Karin, Olsson, Stefan, Orban, Daniel P, Ordonez, Paulina, Orhon, Idil, Orosz, Laszlo, O'Rourke, Eyleen J, Orozco, Helena, Ortega, Angel L, Ortona, Elena, Osellame, Laura D, Oshima, Junko, Oshima, Shigeru, Osiewacz, Heinz D, Otomo, Takanobu, Otsu, Kinya, Ou, Jing Hsiung Jame, Outeiro, Tiago F, Ouyang, Dong Yun, Ouyang, Hongjiao, Overholtzer, Michael, Ozbun, Michelle A, Ozdinler, P. Hande, Ozpolat, Bulent, Pacelli, Consiglia, Paganetti, Paolo, Page, Guylène, Pages, Gille, Pagnini, Ugo, Pajak, Beata, Pak, Stephen C, Pakos Zebrucka, Karolina, Pakpour, Nazzy, Palková, Zdena, Palladino, Francesca, Pallauf, Kathrin, Pallet, Nicola, Palmieri, Marta, Paludan, Søren R, Palumbo, Camilla, Palumbo, Silvia, Pampliega, Olatz, Pan, Hongming, Pan, Wei, Panaretakis, Theochari, Pandey, Aseem, Pantazopoulou, Areti, Papackova, Zuzana, Papademetrio, Daniela L, Papassideri, Issidora, Papini, Alessio, Parajuli, Nirmala, Pardo, Julian, Parekh, Vrajesh V, Parenti, Giancarlo, Park, Jong In, Park, Junsoo, Park, Ohkmae K, Parker, Roy, Parlato, Rosanna, Parys, Jan B, Parzych, Katherine R, Pasquet, Jean Max, Pasquier, Benoit, Pasumarthi, Kishore B, Patschan, Daniel, Patterson, Cam, Pattingre, Sophie, Pattison, Scott, Pause, Arnim, Pavenstädt, Hermann, Pavone, Flaminia, Pedrozo, Zully, Peña, Fernando J, Peñalva, Miguel A, Pende, Mario, Peng, Jianxin, Penna, Fabio, Penninger, Josef M, Pensalfini, Anna, Pepe, Salvatore, Pereira, Gustavo J, Pereira, Paulo C, Pérez de la Cruz, Verónica, Pérez Pérez, María Esther, Pérez Rodríguez, Diego, Pérez Sala, Dolore, Perier, Celine, Perl, Andra, Perlmutter, David H, Perrotta, Ida, Pervaiz, Shazib, Pesonen, Maija, Pessin, Jeffrey E, Peters, Godefridus J, Petersen, Morten, Petrache, Irina, Petrof, Basil J, Petrovski, Goran, Phang, James M, Piacentini, Mauro, Pierdominici, Marina, Pierre, Philippe, Pierrefite Carle, Valérie, Pietrocola, Federico, Pimentel Muiños, Felipe X, Pinar, Mario, Pineda, Benjamin, Pinkas Kramarski, Ronit, Pinti, Marcello, Pinton, Paolo, Piperdi, Bilal, Piret, James M, Platanias, Leonidas C, Platta, Harald W, Plowey, Edward D, Pöggeler, Stefanie, Poirot, Marc, Polčic, Peter, Poletti, Angelo, Poon, Audrey H, Popelka, Hana, Popova, Blagovesta, Poprawa, Izabela, Poulose, Shibu M, Poulton, Joanna, Powers, Scott K, Powers, Ted, Pozuelo Rubio, Mercede, Prak, Krisna, Prange, Reinhild, Prescott, Mark, Priault, Muriel, Prince, Sharon, Proia, Richard L, Proikas Cezanne, Tassula, Prokisch, Holger, Promponas, Vasilis J, Przyklenk, Karin, Puertollano, Rosa, Pugazhenthi, Subbiah, Puglielli, Luigi, Pujol, Aurora, Puyal, Julien, Pyeon, Dohun, Qi, Xin, Qian, Wen Bin, Qin, Zheng Hong, Qiu, Yu, Qu, Ziwei, Quadrilatero, Joe, Quinn, Frederick, Raben, Nina, Rabinowich, Hannah, Radogna, Flavia, Ragusa, Michael J, Rahmani, Mohamed, Raina, Komal, Ramanadham, Sasanka, Ramesh, Rajagopal, Rami, Abdelhaq, Randall Demllo, Sarron, Randow, Felix, Rao, Hai, Rao, V. Ashutosh, Rasmussen, Blake B, Rasse, Tobias M, Ratovitski, Edward A, Rautou, Pierre Emmanuel, Ray, Swapan K, Razani, Babak, Reed, Bruce H, Reggiori, Fulvio, Rehm, Marku, Reichert, Andreas S, Rein, Theo, Reiner, David J, Reits, Eric, Ren, Jun, Ren, Xingcong, Renna, Maurizio, Reusch, Jane Eb, Revuelta, Jose L, Reyes, Leticia, Rezaie, Alireza R, Richards, Robert I, Richardson, Des R, Richetta, Clémence, Riehle, Michael A, Rihn, Bertrand H, Rikihisa, Yasuko, Riley, Brigit E, Rimbach, Gerald, Rippo, Maria Rita, Ritis, Konstantino, Rizzi, Federica, Rizzo, Elizete, Roach, Peter J, Robbins, Jeffrey, Roberge, Michel, Roca, Gabriela, Roccheri, Maria Carmela, Rocha, Sonia, Rodrigues, Cecilia Mp, Rodríguez, Clara I, de Cordoba, Santiago Rodriguez, Rodriguez Muela, Natalia, Roelofs, Jeroen, Rogov, Vladimir V, Rohn, Troy T, Rohrer, Bärbel, Romanelli, Davide, Romani, Luigina, Romano, Patricia Silvia, Roncero, M. Isabel G, Rosa, Jose Lui, Rosello, Alicia, Rosen, Kirill V, Rosenstiel, Philip, Rost Roszkowska, Magdalena, Roth, Kevin A, Roué, Gael, Rouis, Mustapha, Rouschop, Kasper M, Ruan, Daniel T, Ruano, Diego, Rubinsztein, David C, Rucker, Edmund B, Rudich, Assaf, Rudolf, Emil, Rudolf, Ruediger, Ruegg, Markus A, Ruiz Roldan, Carmen, Ruparelia, Avnika Ashok, Rusmini, Paola, Russ, David W, Russo, Gian Luigi, Russo, Giuseppe, Russo, Rossella, Rusten, Tor Erik, Ryabovol, Victoria, Ryan, Kevin M, Ryter, Stefan W, Sabatini, David M, Sacher, Michael, Sachse, Carsten, Sack, Michael N, Sadoshima, Junichi, Saftig, Paul, Sagi Eisenberg, Ronit, Sahni, Sumit, Saikumar, Pothana, Saito, Tsunenori, Saitoh, Tatsuya, Sakakura, Koichi, Sakoh Nakatogawa, Machiko, Sakuraba, Yasuhito, Salazar Roa, María, Salomoni, Paolo, Saluja, Ashok K, Salvaterra, Paul M, Salvioli, Rosa, Samali, Afshin, Sanchez, Anthony Mj, Sánchez Alcázar, José A, Sanchez Prieto, Ricardo, Sandri, Marco, Sanjuan, Miguel A, Santaguida, Stefano, Santambrogio, Laura, Santoni, Giorgio, Dos Santos, Claudia Nune, Saran, Shweta, Sardiello, Marco, Sargent, Graeme, Sarkar, Pallabi, Sarkar, Sovan, Sarrias, Maria Rosa, Sarwal, Minnie M, Sasakawa, Chihiro, Sasaki, Motoko, Sass, Miklo, Sato, Ken, Sato, Miyuki, Satriano, Joseph, Savaraj, Niramol, Saveljeva, Svetlana, Schaefer, Liliana, Schaible, Ulrich E, Scharl, Michael, Schatzl, Hermann M, Schekman, Randy, Scheper, Wiep, Schiavi, Alfonso, Schipper, Hyman M, Schmeisser, Hana, Schmidt, Jen, Schmitz, Ingo, Schneider, Bianca E, Schneider, E. Marion, Schneider, Jaime L, Schon, Eric A, Schönenberger, Miriam J, Schönthal, Axel H, Schorderet, Daniel F, Schröder, Bernd, Schuck, Sebastian, Schulze, Ryan J, Schwarten, Melanie, Schwarz, Thomas L, Sciarretta, Sebastiano, Scotto, Kathleen, Scovassi, A. Ivana, Screaton, Robert A, Screen, Mark, Seca, Hugo, Sedej, Simon, Segatori, Laura, Segev, Nava, Seglen, Per O, Seguí Simarro, Jose M, Segura Aguilar, Juan, Seki, Ekihiro, Sell, Christian, Seiliez, Iban, Semenkovich, Clay F, Semenza, Gregg L, Sen, Utpal, Serra, Andreas L, Serrano Puebla, Ana, Sesaki, Hiromi, Setoguchi, Takao, Settembre, Carmine, Shacka, John J, Shajahan Haq, Ayesha N, Shapiro, Irving M, Sharma, Shweta, She, Hua, Shen, C. K. Jame, Shen, Chiung Chyi, Shen, Han Ming, Shen, Sanbing, Shen, Weili, Sheng, Rui, Sheng, Xianyong, Sheng, Zu Hang, Shepherd, Trevor G, Shi, Junyan, Shi, Qiang, Shi, Qinghua, Shi, Yuguang, Shibutani, Shusaku, Shibuya, Kenichi, Shidoji, Yoshihiro, Shieh, Jeng Jer, Shih, Chwen Ming, Shimada, Yohta, Shimizu, Shigeomi, Shin, Dong Wook, Shinohara, Mari L, Shintani, Michiko, Shintani, Takahiro, Shioi, Tetsuo, Shirabe, Ken, Shiri Sverdlov, Ronit, Shirihai, Orian, Shore, Gordon C, Shu, Chih Wen, Shukla, Deepak, Sibirny, Andriy A, Sica, Valentina, Sigurdson, Christina J, Sigurdsson, Einar M, Sijwali, Puran Singh, Sikorska, Beata, Silveira, Wilian A, Silvente Poirot, Sandrine, Silverman, Gary A, Simak, Jan, Simmet, Thoma, Simon, Anna Katharina, Simon, Hans Uwe, Simone, Cristiano, Simons, Matia, Simonsen, Anne, Singh, Rajat, Singh, Shivendra V, Singh, Shrawan K, Sinha, Debasish, Sinha, Sangita, Sinicrope, Frank A, Sirko, Agnieszka, Sirohi, Kapil, Sishi, Balindiwe Jn, Sittler, Annie, Siu, Parco M, Sivridis, Efthimio, Skwarska, Anna, Slack, Ruth, Slaninová, Iva, Slavov, Nikolai, Smaili, Soraya S, Smalley, Keiran Sm, Smith, Duncan R, Soenen, Stefaan J, Soleimanpour, Scott A, Solhaug, Anita, Somasundaram, Kumaravel, Son, Jin H, Sonawane, Avinash, Song, Chunjuan, Song, Fuyong, Song, Hyun Kyu, Song, Ju Xian, Song, Wei, Soo, Kai Y, Sood, Anil K, Soong, Tuck Wah, Soontornniyomkij, Virawudh, Sorice, Maurizio, Sotgia, Federica, Soto Pantoja, David R, Sotthibundhu, Areechun, Sousa, Maria João, Spaink, Herman P, Span, Paul N, Spang, Anne, Sparks, Janet D, Speck, Peter G, Spector, Stephen A, Spies, Claudia D, Springer, Wolfdieter, Clair, Daret St, Stacchiotti, Alessandra, Staels, Bart, Stang, Michael T, Starczynowski, Daniel T, Starokadomskyy, Petro, Steegborn, Clemen, Steele, John W, Stefanis, Leonida, Steffan, Joan, Stellrecht, Christine M, Stenmark, Harald, Stepkowski, Tomasz M, Stern, Stęphan T, Stevens, Craig, Stockwell, Brent R, Stoka, Veronika, Storchova, Zuzana, Stork, Björn, Stratoulias, Vassili, Stravopodis, Dimitrios J, Strnad, Pavel, Strohecker, Anne Marie, Ström, Anna Lena, Stromhaug, Per, Stulik, Jiri, Su, Yu Xiong, Su, Zhaoliang, Subauste, Carlos S, Subramaniam, Srinivasa, Sue, Carolyn M, Suh, Sang Won, Sui, Xinbing, Sukseree, Supawadee, Sulzer, David, Sun, Fang Lin, Sun, Jiaren, Sun, Jun, Sun, Shi Yong, Sun, Yang, Sun, Yi, Sun, Yingjie, Sundaramoorthy, Vinod, Sung, Joseph, Suzuki, Hidekazu, Suzuki, Kuninori, Suzuki, Naoki, Suzuki, Tadashi, Suzuki, Yuichiro J, Swanson, Michele S, Swanton, Charle, Swärd, Karl, Swarup, Ghanshyam, Sweeney, Sean T, Sylvester, Paul W, Szatmari, Zsuzsanna, Szegezdi, Eva, Szlosarek, Peter W, Taegtmeyer, Heinrich, Tafani, Marco, Taillebourg, Emmanuel, Tait, Stephen Wg, Takacs Vellai, Krisztina, Takahashi, Yoshinori, Takáts, Szabolc, Takemura, Genzou, Takigawa, Nagio, Talbot, Nicholas J, Tamagno, Elena, Tamburini, Jerome, Tan, Cai Ping, Tan, Lan, Tan, Mei Lan, Tan, Ming, Tan, Yee Joo, Tanaka, Keiji, Tanaka, Masaki, Tang, Daolin, Tang, Dingzhong, Tang, Guomei, Tanida, Isei, Tanji, Kunikazu, Tannous, Bakhos A, Tapia, Jose A, Tasset Cuevas, Inmaculada, Tatar, Marc, Tavassoly, Iman, Tavernarakis, Nektario, Taylor, Allen, Taylor, Graham S, Taylor, Gregory A, Taylor, J. Paul, Taylor, Mark J, Tchetina, Elena V, Tee, Andrew R, Teixeira Clerc, Fatima, Telang, Sucheta, Tencomnao, Tewin, Teng, Ba Bie, Teng, Ru Jeng, Terro, Faraj, Tettamanti, Gianluca, Theiss, Arianne L, Theron, Anne E, Thomas, Kelly Jean, Thomé, Marcos P, Thomes, Paul G, Thorburn, Andrew, Thorner, Jeremy, Thum, Thoma, Thumm, Michael, Thurston, Teresa Lm, Tian, Ling, Till, Andrea, Ting, Jenny Pan Yun, Titorenko, Vladimir I, Toker, Lilach, Toldo, Stefano, Tooze, Sharon A, Topisirovic, Ivan, Torgersen, Maria Lyngaa, Torosantucci, Liliana, Torriglia, Alicia, Torrisi, Maria Rosaria, Tournier, Cathy, Towns, Roberto, Trajkovic, Vladimir, Travassos, Leonardo H, Triola, Gemma, Tripathi, Durga Nand, Trisciuoglio, Daniela, Troncoso, Rodrigo, Trougakos, Ioannis P, Truttmann, Anita C, Tsai, Kuen Jer, Tschan, Mario P, Tseng, Yi Hsin, Tsukuba, Takayuki, Tsung, Allan, Tsvetkov, Andrey S, Tu, Shuiping, Tuan, Hsing Yu, Tucci, Marco, Tumbarello, David A, Turk, Bori, Turk, Vito, Turner, Robin Fb, Tveita, Anders A, Tyagi, Suresh C, Ubukata, Makoto, Uchiyama, Yasuo, Udelnow, Andrej, Ueno, Takashi, Umekawa, Midori, Umemiya Shirafuji, Rika, Underwood, Benjamin R, Ungermann, Christian, Ureshino, Rodrigo P, Ushioda, Ryo, Uversky, Vladimir N, Uzcátegui, Néstor L, Vaccari, Thoma, Vaccaro, Maria I, Váchová, Libuše, Vakifahmetoglu Norberg, Helin, Valdor, Rut, Valente, Enza Maria, Vallette, Francoi, Valverde, Angela M, Van den Berghe, Greet, Van Den Bosch, Ludo, van den Brink, Gijs R, van der Goot, F. Gisou, van der Klei, Ida J, van der Laan, Luc Jw, van Doorn, Wouter G, van Egmond, Marjolein, van Golen, Kenneth L, Van Kaer, Luc, van Lookeren Campagne, Menno, Vandenabeele, Peter, Vandenberghe, Wim, Vanhorebeek, Ilse, Varela Nieto, Isabel, Vasconcelos, M. Helena, Vasko, Radovan, Vavvas, Demetrios G, Vega Naredo, Ignacio, Velasco, Guillermo, Velentzas, Athanassios D, Velentzas, Panagiotis D, Vellai, Tibor, Vellenga, Edo, Vendelbo, Mikkel Holm, Venkatachalam, Kartik, Ventura, Natascia, Ventura, Salvador, Veras, Patrícia St, Verdier, Mireille, Vertessy, Beata G, Viale, Andrea, Vidal, Michel, Vieira, Helena L. A, Vierstra, Richard D, Vigneswaran, Nadarajah, Vij, Neeraj, Vila, Miquel, Villar, Margarita, Villar, Victor H, Villarroya, Joan, Vindis, Cécile, Viola, Giampietro, Viscomi, Maria Teresa, Vitale, Giovanni, Vogl, Dan T, Voitsekhovskaja, Olga V, von Haefen, Clarissa, von Schwarzenberg, Karin, Voth, Daniel E, Vouret Craviari, Valérie, Vuori, Kristina, Vyas, Jatin M, Waeber, Christian, Walker, Cheryl Lyn, Walker, Mark J, Walter, Jochen, Wan, Lei, Wan, Xiangbo, Wang, Bo, Wang, Caihong, Wang, Chao Yung, Wang, Chengshu, Wang, Chenran, Wang, Chuangui, Wang, Dong, Wang, Fen, Wang, Fuxin, Wang, Guanghui, Wang, Hai Jie, Wang, Haichao, Wang, Hong Gang, Wang, Hongmin, Wang, Horng Dar, Wang, Jing, Wang, Junjun, Wang, Mei, Wang, Mei Qing, Wang, Pei Yu, Wang, Peng, Wang, Richard C, Wang, Shuo, Wang, Ting Fang, Wang, Xian, Wang, Xiao Jia, Wang, Xiao Wei, Wang, Xin, Wang, Xuejun, Wang, Yan, Wang, Yanming, Wang, Ying, Wang, Ying Jan, Wang, Yipeng, Wang, Yu, Wang, Yu Tian, Wang, Yuqing, Wang, Zhi Nong, Wappner, Pablo, Ward, Carl, Ward, Diane McVey, Warnes, Gary, Watada, Hirotaka, Watanabe, Yoshihisa, Watase, Kei, Weaver, Timothy E, Weekes, Colin D, Wei, Jiwu, Weide, Thoma, Weihl, Conrad C, Weindl, Günther, Weis, Simone Nardin, Wen, Longping, Wen, Xin, Wen, Yunfei, Westermann, Benedikt, Weyand, Cornelia M, White, Anthony R, White, Eileen, Whitton, J. Lindsay, Whitworth, Alexander J, Wiels, Joëlle, Wild, Franziska, Wildenberg, Manon E, Wileman, Tom, Wilkinson, Deepti Sriniva, Wilkinson, Simon, Willbold, Dieter, Williams, Chri, Williams, Katherine, Williamson, Peter R, Winklhofer, Konstanze F, Witkin, Steven S, Wohlgemuth, Stephanie E, Wollert, Thoma, Wolvetang, Ernst J, Wong, Esther, Wong, G. William, Wong, Richard W, Wong, Vincent Kam Wai, Woodcock, Elizabeth A, Wright, Karen L, Wu, Chunlai, Wu, Defeng, Wu, Gen Sheng, Wu, Jian, Wu, Junfang, Wu, Mian, Wu, Min, Wu, Shengzhou, Wu, William Kk, Wu, Yaohua, Wu, Zhenlong, Xavier, Cristina Pr, Xavier, Ramnik J, Xia, Gui Xian, Xia, Tian, Xia, Weiliang, Xia, Yong, Xiao, Hengyi, Xiao, Jian, Xiao, Shi, Xiao, Wuhan, Xie, Chuan Ming, Xie, Zhiping, Xie, Zhonglin, Xilouri, Maria, Xiong, Yuyan, Xu, Chuanshan, Xu, Congfeng, Xu, Feng, Xu, Haoxing, Xu, Hongwei, Xu, Jian, Xu, Jianzhen, Xu, Jinxian, Xu, Liang, Xu, Xiaolei, Xu, Yangqing, Xu, Ye, Xu, Zhi Xiang, Xu, Ziheng, Xue, Yu, Yamada, Takahiro, Yamamoto, Ai, Yamanaka, Koji, Yamashina, Shunhei, Yamashiro, Shigeko, Yan, Bing, Yan, Bo, Yan, Xianghua, Yan, Zhen, Yanagi, Yasuo, Yang, Dun Sheng, Yang, Jin Ming, Yang, Liu, Yang, Minghua, Yang, Pei Ming, Yang, Peixin, Yang, Qian, Yang, Wannian, Yang, Wei Yuan, Yang, Xuesong, Yang, Yi, Yang, Ying, Yang, Zhifen, Yang, Zhihong, Yao, Meng Chao, Yao, Pamela J, Yao, Xiaofeng, Yao, Zhenyu, Yao, Zhiyuan, Yasui, Linda S, Ye, Mingxiang, Yedvobnick, Barry, Yeganeh, Behzad, Yeh, Elizabeth S, Yeyati, Patricia L, Yi, Fan, Yi, Long, Yin, Xiao Ming, Yip, Calvin K, Yoo, Yeong Min, Yoo, Young Hyun, Yoon, Seung Yong, Yoshida, Ken Ichi, Yoshimori, Tamotsu, Young, Ken H, Yu, Huixin, Yu, Jane J, Yu, Jin Tai, Yu, Jun, Yu, Li, Yu, W. Haung, Yu, Xiao Fang, Yu, Zhengping, Yuan, Junying, Yuan, Zhi Min, Yue, Beatrice Yjt, Yue, Jianbo, Yue, Zhenyu, Zacks, David N, Zacksenhaus, Eldad, Zaffaroni, Nadia, Zaglia, Tania, Zakeri, Zahra, Zecchini, Vincent, Zeng, Jinsheng, Zeng, Min, Zeng, Qi, Zervos, Antonis S, Zhang, Donna D, Zhang, Fan, Zhang, Guo, Zhang, Guo Chang, Zhang, Hao, Zhang, Hong, Zhang, Hongbing, Zhang, Jian, Zhang, Jiangwei, Zhang, Jianhua, Zhang, Jing Pu, Zhang, Li, Zhang, Lin, Zhang, Long, Zhang, Ming Yong, Zhang, Xiangnan, Zhang, Xu Dong, Zhang, Yan, Zhang, Yang, Zhang, Yanjin, Zhang, Yingmei, Zhang, Yunjiao, Zhao, Mei, Zhao, Wei Li, Zhao, Xiaonan, Zhao, Yan G, Zhao, Ying, Zhao, Yongchao, Zhao, Yu Xia, Zhao, Zhendong, Zhao, Zhizhuang J, Zheng, Dexian, Zheng, Xi Long, Zheng, Xiaoxiang, Zhivotovsky, Bori, Zhong, Qing, Zhou, Guang Zhou, Zhou, Guofei, Zhou, Huiping, Zhou, Shu Feng, Zhou, Xu Jie, Zhu, Hongxin, Zhu, Hua, Zhu, Wei Guo, Zhu, Wenhua, Zhu, Xiao Feng, Zhu, Yuhua, Zhuang, Shi Mei, Zhuang, Xiaohong, Ziparo, Elio, Zois, Christos E, Zoladek, Teresa, Zong, Wei Xing, Zorzano, Antonio, Zughaier, Susu M., MEDINA SANABRIA, Diego Luis, RS: GROW - R2 - Basic and Translational Cancer Biology, RS: NUTRIM - R2 - Gut-liver homeostasis, Molecular Genetics, Beeldvorming, Genetica & Celbiologie, Medical oncology laboratory, CCA - Target Discovery & Preclinial Therapy Development, Pathology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, CCA - Clinical Therapy Development, Human genetics, Surgery, Molecular cell biology and Immunology, Klionsky, Dj, Abdelmohsen, K, Abe, A, Abedin, Mj, Abeliovich, H, Acevedo Arozena, A, Adachi, H, Adams, Cm, Adams, Pd, Adeli, K, Adhihetty, Pj, Adler, Sg, Agam, G, Agarwal, R, Aghi, Mk, Agnello, M, Agostinis, P, Aguilar, Pv, Aguirre Ghiso, J, Airoldi, Em, Ait Si Ali, S, Akematsu, T, Akporiaye, Et, Al Rubeai, M, Albaiceta, Gm, Albanese, C, Albani, D, Albert, Ml, Aldudo, J, Algül, H, Alirezaei, M, Alloza, I, Almasan, A, Almonte Beceril, M, Alnemri, E, Alonso, C, Altan Bonnet, N, Altieri, Dc, Alvarez, S, Alvarez Erviti, L, Alves, S, Amadoro, G, Amano, A, Amantini, C, Ambrosio, S, Amelio, I, Amer, Ao, Amessou, M, Amon, A, An, Z, Anania, Fa, Andersen, Su, Andley, Up, Andreadi, Ck, Andrieu Abadie, N, Anel, A, Ann, Dk, Anoopkumar Dukie, S, Antonioli, M, Aoki, H, Apostolova, N, Aquila, S, Aquilano, K, Araki, K, Arama, E, Aranda, A, Araya, J, Arcaro, A, Arias, E, Arimoto, H, Ariosa, Ar, Armstrong, Jl, Arnould, T, Arsov, I, Asanuma, K, Askanas, V, Asselin, E, Atarashi, R, Atherton, S, Atkin, Jd, Attardi, Ld, Auberger, P, Auburger, G, Aurelian, L, Autelli, R, Avagliano, L, Avantaggiati, Ml, Avrahami, L, Awale, S, Azad, N, Bachetti, T, Backer, Jm, Bae, Dh, Bae, J, Bae, On, Bae, Sh, Baehrecke, Eh, Baek, Sh, Baghdiguian, S, Bagniewska Zadworna, A, Bai, H, Bai, J, Bai, Xy, Bailly, Y, Balaji, Kn, Balduini, W, Ballabio, A, Balzan, R, Banerjee, R, Bánhegyi, G, Bao, H, Barbeau, B, Barrachina, Md, Barreiro, E, Bartel, B, Bartolomé, A, Bassham, Dc, Bassi, Mt, Bast RC, Jr, Basu, A, Batista, Mt, Batoko, H, Battino, M, Bauckman, K, Baumgarner, Bl, Bayer, Ku, Beale, R, Beaulieu, Jf, Beck GR, Jr, Becker, C, Beckham, Jd, Bédard, Pa, Bednarski, Pj, Begley, Tj, Behl, C, Behrends, C, Behrens, Gm, Behrns, Ke, Bejarano, E, Belaid, A, Belleudi, F, Bénard, G, Berchem, G, Bergamaschi, D, Bergami, M, Berkhout, B, Berliocchi, L, Bernard, A, Bernard, M, Bernassola, F, Bertolotti, A, Bess, A, Besteiro, S, Bettuzzi, S, Bhalla, S, Bhattacharyya, S, Bhutia, Sk, Biagosch, C, Bianchi, Mw, Biard Piechaczyk, M, Billes, V, Bincoletto, C, Bingol, B, Bird, Sw, Bitoun, M, Bjedov, I, Blackstone, C, Blanc, L, Blanco, Ga, Blomhoff, Hk, Boada Romero, E, Böckler, S, Boes, M, Boesze Battaglia, K, Boise, Lh, Bolino, A, Boman, A, Bonaldo, P, Bordi, M, Bosch, J, Botana, Lm, Botti, J, Bou, G, Bouché, M, Bouchecareilh, M, Boucher, Mj, Boulton, Me, Bouret, Sg, Boya, P, Boyer Guittaut, M, Bozhkov, Pv, Brady, N, Braga, Vm, Brancolini, C, Braus, Gh, Bravo San Pedro, Jm, Brennan, La, Bresnick, Eh, Brest, P, Bridges, D, Bringer, Ma, Brini, M, Brito, Gc, Brodin, B, Brookes, P, Brown, Ej, Brown, K, Broxmeyer, He, Bruhat, A, Brum, Pc, Brumell, Jh, Brunetti Pierri, N, Bryson Richardson, Rj, Buch, S, Buchan, Am, Budak, H, Bulavin, Dv, Bultman, Sj, Bultynck, G, Bumbasirevic, V, Burelle, Y, Burke, Re, Burmeister, M, Bütikofer, P, Caberlotto, L, Cadwell, K, Cahova, M, Cai, D, Cai, J, Cai, Q, Calatayud, S, Camougrand, N, Campanella, M, Campbell, Gr, Campbell, M, Campello, S, Candau, R, Caniggia, I, Cantoni, L, Cao, L, Caplan, Ab, Caraglia, M, Cardinali, C, Cardoso, Sm, Carew, J, Carleton, La, Carlin, Cr, Carloni, S, Carlsson, Sr, Carmona Gutierrez, D, Carneiro, La, Carnevali, O, Carra, S, Carrier, A, Carroll, B, Casas, C, Casas, J, Cassinelli, G, Castets, P, Castro Obregon, S, Cavallini, G, Ceccherini, I, Cecconi, F, Cederbaum, Ai, Ceña, V, Cenci, S, Cerella, C, Cervia, D, Cetrullo, S, Chaachouay, H, Chae, Hj, Chagin, A, Chai, Cy, Chakrabarti, G, Chamilos, G, Chan, Ey, Chan, Mt, Chandra, D, Chandra, P, Chang, Cp, Chang, Rc, Chang, Ty, Chatham, Jc, Chatterjee, S, Chauhan, S, Che, Y, Cheetham, Me, Cheluvappa, R, Chen, Cj, Chen, G, Chen, Gc, Chen, H, Chen, Jw, Chen, Jk, Chen, M, Chen, P, Chen, Q, Chen, Sd, Chen, S, Chen, W, Chen, Wj, Chen, Wq, Chen, X, Chen, Yh, Chen, Yg, Chen, Y, Chen, Yj, Chen, Yq, Chen, Z, Cheng, A, Cheng, Ch, Cheng, H, Cheong, H, Cherry, S, Chesney, J, Cheung, Ch, Chevet, E, Chi, Hc, Chi, Sg, Chiacchiera, F, Chiang, Hl, Chiarelli, R, Chiariello, M, Chieppa, M, Chin, L, Chiong, M, Chiu, Gn, Cho, Dh, Cho, Sg, Cho, Wc, Cho, Yy, Cho, Y, Choi, Am, Choi, Ej, Choi, Ek, Choi, J, Choi, Me, Choi, Si, Chou, Tf, Chouaib, S, Choubey, D, Choubey, V, Chow, Kc, Chowdhury, K, Chu, Ct, Chuang, Th, Chun, T, Chung, H, Chung, T, Chung, Yl, Chwae, Yj, Cianfanelli, V, Ciarcia, R, Ciechomska, Ia, Ciriolo, Mr, Cirone, M, Claerhout, S, Clague, Mj, Clària, J, Clarke, Pg, Clarke, R, Clementi, E, Cleyrat, C, Cnop, M, Coccia, Em, Cocco, T, Codogno, P, Coers, J, Cohen, Ee, Colecchia, D, Coletto, L, Coll, N, Colucci Guyon, E, Comincini, S, Condello, M, Cook, Kl, Coombs, Gh, Cooper, Cd, Cooper, Jm, Coppens, I, Corasaniti, Mt, Corazzari, M, Corbalan, R, Corcelle Termeau, E, Cordero, Md, Corral Ramos, C, Corti, O, Cossarizza, A, Costelli, P, Costes, S, Cotman, Sl, Coto Montes, A, Cottet, S, Couve, E, Covey, Lr, Cowart, La, Cox, J, Coxon, Fp, Coyne, Cb, Cragg, M, Craven, Rj, Crepaldi, T, Crespo, Jl, Criollo, A, Crippa, V, Cruz, Mt, Cuervo, Am, Cuezva, Jm, Cui, T, Cutillas, Pr, Czaja, Mj, Czyzyk Krzeska, Mf, Dagda, Rk, Dahmen, U, Dai, C, Dai, W, Dai, Y, Dalby, Kn, Dalla Valle, L, Dalmasso, G, D'Amelio, M, Damme, M, Darfeuille Michaud, A, Dargemont, C, Darley Usmar, Vm, Dasarathy, S, Dasgupta, B, Dash, S, Dass, Cr, Davey, Hm, Davids, Lm, Dávila, D, Davis, Rj, Dawson, Tm, Dawson, Vl, Daza, P, de Belleroche, J, de Figueiredo, P, de Figueiredo, Rc, de la Fuente, J, De Martino, L, De Matteis, A, De Meyer, Gr, De Milito, A, De Santi, M, de Souza, W, De Tata, V, De Zio, D, Debnath, J, Dechant, R, Decuypere, Jp, Deegan, S, Dehay, B, Del Bello, B, Del Re, Dp, Delage Mourroux, R, Delbridge, Lm, Deldicque, L, Delorme Axford, E, Deng, Y, Dengjel, J, Denizot, M, Dent, P, Der, Cj, Deretic, V, Derrien, B, Deutsch, E, Devarenne, Tp, Devenish, Rj, Di Bartolomeo, S, Di Daniele, N, Di Domenico, F, Di Nardo, A, Di Paola, S, Di Pietro, A, Di Renzo, L, Diantonio, A, Díaz Araya, G, Díaz Laviada, I, Diaz Meco, Mt, Diaz Nido, J, Dickey, Ca, Dickson, Rc, Diederich, M, Digard, P, Dikic, I, Dinesh Kumar, Sp, Ding, C, Ding, Wx, Ding, Z, Distler, Jh, Diwan, A, Djavaheri Mergny, M, Dmytruk, K, Dobson, Rc, Doetsch, V, Dokladny, K, Dokudovskaya, S, Donadelli, M, Dong, Xc, Dong, X, Dong, Z, Donohue TM, Jr, Doran, K, D'Orazi, G, Dorn GW, 2nd, Dosenko, V, Dridi, S, Drucker, L, Du, J, Du, Ll, Du, L, du Toit, A, Dua, P, Duan, L, Duann, P, Dubey, Vk, Duchen, Mr, Duchosal, Ma, Duez, H, Dugail, I, Dumit, Vi, Duncan, Mc, Dunlop, Ea, Dunn WA, Jr, Dupont, N, Dupuis, L, Durán, Rv, Durcan, Tm, Duvezin Caubet, S, Duvvuri, U, Eapen, V, Ebrahimi Fakhari, D, Echard, A, Eckhart, L, Edelstein, Cl, Edinger, Al, Eichinger, L, Eisenberg, T, Eisenberg Lerner, A, Eissa, Nt, El Deiry, W, El Khoury, V, Elazar, Z, Eldar Finkelman, H, Elliott, Cj, Emanuele, E, Emmenegger, U, Engedal, N, Engelbrecht, Am, Engelender, S, Enserink, Jm, Erdmann, R, Erenpreisa, J, Eri, R, Eriksen, Jl, Erman, A, Escalante, R, Eskelinen, El, Espert, L, Esteban Martínez, L, Evans, Tj, Fabri, M, Fabrias, G, Fabrizi, C, Facchiano, A, Færgeman, Nj, Faggioni, A, Fairlie, Wd, Fan, C, Fan, D, Fan, J, Fang, S, Fanto, M, Fanzani, A, Farkas, T, Faure, M, Favier, Fb, Fearnhead, H, Federici, M, Fei, E, Felizardo, Tc, Feng, H, Feng, Y, Ferguson, Ta, Fernández, Áf, Fernandez Barrena, Mg, Fernandez Checa, Jc, Fernández López, A, Fernandez Zapico, Me, Feron, O, Ferraro, E, Ferreira Halder, Cv, Fesus, L, Feuer, R, Fiesel, Fc, Filippi Chiela, Ec, Filomeni, G, Fingert, Jh, Finkbeiner, S, Finkel, T, Fiorito, F, Fisher, Pb, Flajolet, M, Flamigni, F, Florey, O, Florio, S, Floto, Ra, Folini, M, Follo, C, Fon, Ea, Fornai, F, Fortunato, F, Fraldi, A, Franco, R, Francois, A, François, A, Frankel, Lb, Fraser, Id, Frey, N, Freyssenet, Dg, Frezza, C, Friedman, Sl, Frigo, De, Fu, D, Fuentes, Jm, Fueyo, J, Fujitani, Y, Fujiwara, Y, Fujiya, M, Fukuda, M, Fulda, S, Fusco, C, Gabryel, B, Gaestel, M, Gailly, P, Gajewska, M, Galadari, S, Galili, G, Galindo, I, Galindo, Mf, Galliciotti, G, Galluzzi, L, Galy, V, Gammoh, N, Gandy, S, Ganesan, Ak, Ganesan, S, Ganley, Ig, Gannagé, M, Gao, Fb, Gao, F, Gao, Jx, García Nannig, L, García Véscovi, E, Garcia Macía, M, Garcia Ruiz, C, Garg, Ad, Garg, Pk, Gargini, R, Gassen, Nc, Gatica, D, Gatti, E, Gavard, J, Gavathiotis, E, Ge, L, Ge, P, Ge, S, Gean, Pw, Gelmetti, V, Genazzani, Aa, Geng, J, Genschik, P, Gerner, L, Gestwicki, Je, Gewirtz, Da, Ghavami, S, Ghigo, E, Ghosh, D, Giammarioli, Am, Giampieri, F, Giampietri, C, Giatromanolaki, A, Gibbings, Dj, Gibellini, L, Gibson, Sb, Ginet, V, Giordano, A, Giorgini, F, Giovannetti, E, Girardin, Se, Gispert, S, Giuliano, S, Gladson, Cl, Glavic, A, Gleave, M, Godefroy, N, Gogal RM, Jr, Gokulan, K, Goldman, Gh, Goletti, D, Goligorsky, M, Gomes, Av, Gomes, Lc, Gomez, H, Gomez Manzano, C, Gómez Sánchez, R, Gonçalves, Da, Goncu, E, Gong, Q, Gongora, C, Gonzalez, Cb, Gonzalez Alegre, P, Gonzalez Cabo, P, González Polo, Ra, Goping, I, Gorbea, C, Gorbunov, Nv, Goring, Dr, Gorman, Am, Gorski, Sm, Goruppi, S, Goto Yamada, S, Gotor, C, Gottlieb, Ra, Gozes, I, Gozuacik, D, Graba, Y, Graef, M, Granato, Ge, Grant, Gd, Grant, S, Gravina, Gl, Green, Dr, Greenhough, A, Greenwood, Mt, Grimaldi, B, Gros, F, Grose, C, Groulx, Jf, Gruber, F, Grumati, P, Grune, T, Guan, Jl, Guan, Kl, Guerra, B, Guillen, C, Gulshan, K, Gunst, J, Guo, C, Guo, L, Guo, M, Guo, W, Guo, Xg, Gust, Aa, Gustafsson, Åb, Gutierrez, E, Gutierrez, Mg, Gwak, H, Haas, A, Haber, Je, Hadano, S, Hagedorn, M, Hahn, Dr, Halayko, Aj, Hamacher Brady, A, Hamada, K, Hamai, A, Hamann, A, Hamasaki, M, Hamer, I, Hamid, Q, Hammond, Em, Han, F, Han, W, Handa, Jt, Hanover, Ja, Hansen, M, Harada, M, Harhaji Trajkovic, L, Harper, Jw, Harrath, Ah, Harris, Al, Harris, J, Hasler, U, Hasselblatt, P, Hasui, K, Hawley, Rg, Hawley, T, He, C, He, Cy, He, F, He, G, He, Rr, He, Xh, He, Yw, He, Yy, Heath, Jk, Hébert, Mj, Heinzen, Ra, Helgason, Gv, Hensel, M, Henske, Ep, Her, C, Herman, Pk, Hernández, A, Hernandez, C, Hernández Tiedra, S, Hetz, C, Hiesinger, Pr, Higaki, K, Hilfiker, S, Hill, Bg, Hill, Ja, Hill, Wd, Hino, K, Hofius, D, Hofman, P, Höglinger, Gu, Höhfeld, J, Holz, Mk, Hong, Y, Hood, Da, Hoozemans, Jj, Hoppe, T, Hsu, C, Hsu, Cy, Hsu, Lc, Hu, D, Hu, G, Hu, Hm, Hu, H, Hu, Mc, Hu, Yc, Hu, Zw, Hua, F, Hua, Y, Huang, C, Huang, Hl, Huang, Kh, Huang, Ky, Huang, S, Huang, Wp, Huang, Yr, Huang, Y, Huber, Tb, Huebbe, P, Huh, Wk, Hulmi, Jj, Hur, Gm, Hurley, Jh, Husak, Z, Hussain, Sn, Hussain, S, Hwang, Jj, Hwang, S, Hwang, Ti, Ichihara, A, Imai, Y, Imbriano, C, Inomata, M, Into, T, Iovane, V, Iovanna, Jl, Iozzo, Rv, Ip, Ny, Irazoqui, Je, Iribarren, P, Isaka, Y, Isakovic, Aj, Ischiropoulos, H, Isenberg, J, Ishaq, M, Ishida, H, Ishii, I, Ishmael, Je, Isidoro, C, Isobe, Ki, Isono, E, Issazadeh Navikas, S, Itahana, K, Itakura, E, Ivanov, Ai, Iyer, Ak, Izquierdo, Jm, Izumi, Y, Izzo, V, Jäättelä, M, Jaber, N, Jackson, Dj, Jackson, Wt, Jacob, Tg, Jacques, T, Jagannath, C, Jain, A, Jana, Nr, Jang, Bk, Jani, A, Janji, B, Jannig, Pr, Jansson, Pj, Jean, S, Jendrach, M, Jeon, Jh, Jessen, N, Jeung, Eb, Jia, K, Jia, L, Jiang, H, Jiang, L, Jiang, T, Jiang, X, Jiang, Y, Jiménez, A, Jin, C, Jin, H, Jin, L, Jin, M, Jin, S, Jinwal, Uk, Jo, Ek, Johansen, T, Johnson, De, Johnson, Gv, Johnson, Jd, Jonasch, E, Jones, C, Joosten, La, Jordan, J, Joseph, Am, Joseph, B, Joubert, Am, Ju, D, Ju, J, Juan, Hf, Juenemann, K, Juhász, G, Jung, H, Jung, Ju, Jung, Yk, Jungbluth, H, Justice, Mj, Jutten, B, Kaakoush, No, Kaarniranta, K, Kaasik, A, Kabuta, T, Kaeffer, B, Kågedal, K, Kahana, A, Kajimura, S, Kakhlon, O, Kalia, M, Kalvakolanu, Dv, Kamada, Y, Kambas, K, Kaminskyy, Vo, Kampinga, Hh, Kandouz, M, Kang, C, Kang, R, Kang, Tc, Kanki, T, Kanneganti, Td, Kanno, H, Kanthasamy, Ag, Kantorow, M, Kaparakis Liaskos, M, Kapuy, O, Karantza, V, Karim, Mr, Karmakar, P, Kaser, A, Kaushik, S, Kawula, T, Kaynar, Am, Ke, Py, Ke, Zj, Kehrl, Jh, Keller, Ke, Kemper, Jk, Kenworthy, Ak, Kepp, O, Kern, A, Kesari, S, Kessel, D, Ketteler, R, Kettelhut, Id, Khambu, B, Khan, Mm, Khandelwal, Vk, Khare, S, Kiang, Jg, Kiger, Aa, Kihara, A, Kim, Al, Kim, Ch, Kim, Dr, Kim, Dh, Kim, Ek, Kim, Hy, Kim, Hr, Kim, J, Kim, Jh, Kim, Jc, Kim, Kw, Kim, Md, Kim, Mm, Kim, Pk, Kim, Sw, Kim, Sy, Kim, Y, Kimchi, A, Kimmelman, Ac, Kimura, T, King, J, Kirkegaard, K, Kirkin, V, Kirshenbaum, La, Kishi, S, Kitajima, Y, Kitamoto, K, Kitaoka, Y, Kitazato, K, Kley, Ra, Klimecki, Wt, Klinkenberg, M, Klucken, J, Knævelsrud, H, Knecht, E, Knuppertz, L, Ko, Jl, Kobayashi, S, Koch, Jc, Koechlin Ramonatxo, C, Koenig, U, Koh, Yh, Köhler, K, Kohlwein, Sd, Koike, M, Komatsu, M, Kominami, E, Kong, D, Kong, Hj, Konstantakou, Eg, Kopp, Bt, Korcsmaros, T, Korhonen, L, Korolchuk, Vi, Koshkina, Nv, Kou, Y, Koukourakis, Mi, Koumenis, C, Kovács, Al, Kovács, T, Kovacs, Wj, Koya, D, Kraft, C, Krainc, D, Kramer, H, Kravic Stevovic, T, Krek, W, Kretz Remy, C, Krick, R, Krishnamurthy, M, Kriston Vizi, J, Kroemer, G, Kruer, Mc, Kruger, R, Ktistakis, Nt, Kuchitsu, K, Kuhn, C, Kumar, Ap, Kumar, A, Kumar, D, Kumar, R, Kumar, S, Kundu, M, Kung, Hj, Kuno, A, Kuo, Sh, Kuret, J, Kurz, T, Kwok, T, Kwon, Tk, Kwon, Yt, Kyrmizi, I, La Spada, Ar, Lafont, F, Lahm, T, Lakkaraju, A, Lam, T, Lamark, T, Lancel, S, Landowski, Th, Lane, Dj, Lane, Jd, Lanzi, C, Lapaquette, P, Lapierre, Lr, Laporte, J, Laukkarinen, J, Laurie, Gw, Lavandero, S, Lavie, L, Lavoie, Mj, Law, By, Law, Hk, Law, Kb, Layfield, R, Lazo, Pa, Le Cam, L, Le Roch, Kg, Le Stunff, H, Leardkamolkarn, V, Lecuit, M, Lee, Bh, Lee, Ch, Lee, Ef, Lee, Gm, Lee, Hj, Lee, H, Lee, Jk, Lee, J, Lee, Jh, Lee, M, Lee, Pj, Lee, Sw, Lee, Sj, Lee, Sy, Lee, Sh, Lee, S, Lee, Yr, Lee, Yj, Lee, Yh, Leeuwenburgh, C, Lefort, S, Legouis, R, Lei, J, Lei, Qy, Leib, Da, Leibowitz, G, Lekli, I, Lemaire, Sd, Lemasters, Jj, Lemberg, Mk, Lemoine, A, Leng, S, Lenz, G, Lenzi, P, Lerman, Lo, Lettieri Barbato, D, Leu, Ji, Leung, Hy, Levine, B, Lewis, Pa, Lezoualc'H, F, Li, C, Li, F, Li, Fj, Li, J, Li, K, Li, L, Li, M, Li, Q, Li, R, Li, S, Li, W, Li, X, Li, Y, Lian, J, Liang, C, Liang, Q, Liao, Y, Liberal, J, Liberski, Pp, Lie, P, Lieberman, Ap, Lim, Hj, Lim, Kl, Lim, K, Lima, Rt, Lin, C, Lin, Cf, Lin, F, Lin, Fc, Lin, K, Lin, Kh, Lin, Ph, Lin, T, Lin, Ww, Lin, Y, Linden, R, Lindholm, D, Lindqvist, Lm, Lingor, P, Linkermann, A, Liotta, La, Lipinski, Mm, Lira, Va, Lisanti, Mp, Liton, Pb, Liu, B, Liu, C, Liu, Cf, Liu, F, Liu, Hj, Liu, J, Liu, Jj, Liu, Jl, Liu, K, Liu, L, Liu, Q, Liu, Ry, Liu, S, Liu, W, Liu, Xd, Liu, X, Liu, Xh, Liu, Y, Liu, Z, Liuzzi, Jp, Lizard, G, Ljujic, M, Lodhi, Ij, Logue, Se, Lokeshwar, Bl, Long, Yc, Lonial, S, Loos, B, López Otín, C, López Vicario, C, Lorente, M, Lorenzi, Pl, Lõrincz, P, Los, M, Lotze, Mt, Lovat, Pe, Lu, B, Lu, J, Lu, Q, Lu, Sm, Lu, S, Lu, Y, Luciano, F, Luckhart, S, Lucocq, Jm, Ludovico, P, Lugea, A, Lukacs, Nw, Lum, Jj, Lund, Ah, Luo, H, Luo, J, Luo, S, Luparello, C, Lyons, T, Ma, J, Ma, Y, Ma, Z, Machado, J, Machado Santelli, Gm, Macian, F, Macintosh, Gc, Mackeigan, Jp, Macleod, Kf, Macmicking, Jd, MacMillan Crow, La, Madeo, F, Madesh, M, Madrigal Matute, J, Maeda, A, Maeda, T, Maegawa, G, Maellaro, E, Maes, H, Magariños, M, Maiese, K, Maiti, Tk, Maiuri, L, Maiuri, Mc, Maki, Cg, Malli, R, Malorni, W, Maloyan, A, Mami Chouaib, F, Man, N, Mancias, Jd, Mandelkow, Em, Mandell, Ma, Manfredi, Aa, Manié, Sn, Manzoni, C, Mao, K, Mao, Z, Mao, Zw, Marambaud, P, Marconi, Am, Marelja, Z, Marfe, G, Margeta, M, Margittai, E, Mari, M, Mariani, Fv, Marin, C, Marinelli, S, Mariño, G, Markovic, I, Marquez, R, Martelli, Am, Martens, S, Martin, Kr, Martin, Sj, Martin, S, Martin Acebes, Ma, Martín Sanz, P, Martinand Mari, C, Martinet, W, Martinez, J, Martinez Lopez, N, Martinez Outschoorn, U, Martínez Velázquez, M, Martinez Vicente, M, Martins, Wk, Mashima, H, Mastrianni, Ja, Matarese, G, Matarrese, P, Mateo, R, Matoba, S, Matsumoto, N, Matsushita, T, Matsuura, A, Matsuzawa, T, Mattson, Mp, Matus, S, Maugeri, N, Mauvezin, C, Mayer, A, Maysinger, D, Mazzolini, Gd, Mcbrayer, Mk, Mccall, K, Mccormick, C, Mcinerney, Gm, Mciver, Sc, Mckenna, S, Mcmahon, Jj, Mcneish, Ia, Mechta Grigoriou, F, Medema, Jp, Medina, Dl, Megyeri, K, Mehrpour, M, Mehta, Jl, Mei, Y, Meier, Uc, Meijer, Aj, Meléndez, A, Melino, G, Melino, S, de Melo, Ej, Mena, Ma, Meneghini, Md, Menendez, Ja, Menezes, R, Meng, L, Meng, Lh, Meng, S, Menghini, R, Menko, A, Menna Barreto, Rf, Menon, Mb, Meraz Ríos, Ma, Merla, G, Merlini, L, Merlot, Am, Meryk, A, Meschini, S, Meyer, Jn, Mi, Mt, Miao, Cy, Micale, L, Michaeli, S, Michiels, C, Migliaccio, Ar, Mihailidou, A, Mijaljica, D, Mikoshiba, K, Milan, E, Miller Fleming, L, Mills, Gb, Mills, Ig, Minakaki, G, Minassian, Ba, Ming, Xf, Minibayeva, F, Minina, Ea, Mintern, Jd, Minucci, S, Miranda Vizuete, A, Mitchell, Ch, Miyamoto, S, Miyazawa, K, Mizushima, N, Mnich, K, Mograbi, B, Mohseni, S, Moita, Lf, Molinari, M, Møller, Ab, Mollereau, B, Mollinedo, F, Mongillo, M, Monick, Mm, Montagnaro, S, Montell, C, Moore, Dj, Moore, Mn, Mora Rodriguez, R, Moreira, Pi, Morel, E, Morelli, Mb, Moreno, S, Morgan, Mj, Moris, A, Moriyasu, Y, Morrison, Jl, Morrison, La, Morselli, E, Moscat, J, Moseley, Pl, Mostowy, S, Motori, E, Mottet, D, Mottram, Jc, Moussa, Ce, Mpakou, Ve, Mukhtar, H, Mulcahy Levy, Jm, Muller, S, Muñoz Moreno, R, Muñoz Pinedo, C, Münz, C, Murphy, Me, Murray, Jt, Murthy, A, Mysorekar, Iu, Nabi, Ir, Nabissi, M, Nader, Ga, Nagahara, Y, Nagai, Y, Nagata, K, Nagelkerke, A, Nagy, P, Naidu, Sr, Nair, S, Nakano, H, Nakatogawa, H, Nanjundan, M, Napolitano, G, Naqvi, Ni, Nardacci, R, Narendra, Dp, Narita, M, Nascimbeni, Ac, Natarajan, R, Navegantes, Lc, Nawrocki, St, Nazarko, Ty, Nazarko, Vy, Neill, T, Neri, Lm, Netea, Mg, Netea Maier, Rt, Neves, Bm, Ney, Pa, Nezis, Ip, Nguyen, Ht, Nguyen, Hp, Nicot, A, Nilsen, H, Nilsson, P, Nishimura, M, Nishino, I, Niso Santano, M, Niu, H, Nixon, Ra, Njar, Vc, Noda, T, Noegel, Aa, Nolte, Em, Norberg, E, Norga, Kk, Noureini, Sk, Notomi, S, Notterpek, L, Nowikovsky, K, Nukina, N, Nürnberger, T, O'Donnell, Vb, O'Donovan, T, O'Dwyer, Pj, Oehme, I, Oeste, Cl, Ogawa, M, Ogretmen, B, Ogura, Y, Oh, Yj, Ohmuraya, M, Ohshima, T, Ojha, R, Okamoto, K, Okazaki, T, Oliver, Fj, Ollinger, K, Olsson, S, Orban, Dp, Ordonez, P, Orhon, I, Orosz, L, O'Rourke, Ej, Orozco, H, Ortega, Al, Ortona, E, Osellame, Ld, Oshima, J, Oshima, S, Osiewacz, Hd, Otomo, T, Otsu, K, Ou, Jj, Outeiro, Tf, Ouyang, Dy, Ouyang, H, Overholtzer, M, Ozbun, Ma, Ozdinler, Ph, Ozpolat, B, Pacelli, C, Paganetti, P, Page, G, Pages, G, Pagnini, U, Pajak, B, Pak, Sc, Pakos Zebrucka, K, Pakpour, N, Palková, Z, Palladino, F, Pallauf, K, Pallet, N, Palmieri, M, Paludan, Sr, Palumbo, C, Palumbo, S, Pampliega, O, Pan, H, Pan, W, Panaretakis, T, Pandey, A, Pantazopoulou, A, Papackova, Z, Papademetrio, Dl, Papassideri, I, Papini, A, Parajuli, N, Pardo, J, Parekh, Vv, Parenti, G, Park, Ji, Park, J, Park, Ok, Parker, R, Parlato, R, Parys, Jb, Parzych, Kr, Pasquet, Jm, Pasquier, B, Pasumarthi, Kb, Patschan, D, Patterson, C, Pattingre, S, Pattison, S, Pause, A, Pavenstädt, H, Pavone, F, Pedrozo, Z, Peña, Fj, Peñalva, Ma, Pende, M, Peng, J, Penna, F, Penninger, Jm, Pensalfini, A, Pepe, S, Pereira, Gj, Pereira, Pc, Pérez de la Cruz, V, Pérez Pérez, Me, Pérez Rodríguez, D, Pérez Sala, D, Perier, C, Perl, A, Perlmutter, Dh, Perrotta, I, Pervaiz, S, Pesonen, M, Pessin, Je, Peters, Gj, Petersen, M, Petrache, I, Petrof, Bj, Petrovski, G, Phang, Jm, Piacentini, M, Pierdominici, M, Pierre, P, Pierrefite Carle, V, Pietrocola, F, Pimentel Muiños, Fx, Pinar, M, Pineda, B, Pinkas Kramarski, R, Pinti, M, Pinton, P, Piperdi, B, Piret, Jm, Platanias, Lc, Platta, Hw, Plowey, Ed, Pöggeler, S, Poirot, M, Polčic, P, Poletti, A, Poon, Ah, Popelka, H, Popova, B, Poprawa, I, Poulose, Sm, Poulton, J, Powers, Sk, Powers, T, Pozuelo Rubio, M, Prak, K, Prange, R, Prescott, M, Priault, M, Prince, S, Proia, Rl, Proikas Cezanne, T, Prokisch, H, Promponas, Vj, Przyklenk, K, Puertollano, R, Pugazhenthi, S, Puglielli, L, Pujol, A, Puyal, J, Pyeon, D, Qi, X, Qian, Wb, Qin, Zh, Qiu, Y, Qu, Z, Quadrilatero, J, Quinn, F, Raben, N, Rabinowich, H, Radogna, F, Ragusa, Mj, Rahmani, M, Raina, K, Ramanadham, S, Ramesh, R, Rami, A, Randall Demllo, S, Randow, F, Rao, H, Rao, Va, Rasmussen, Bb, Rasse, Tm, Ratovitski, Ea, Rautou, Pe, Ray, Sk, Razani, B, Reed, Bh, Reggiori, F, Rehm, M, Reichert, A, Rein, T, Reiner, Dj, Reits, E, Ren, J, Ren, X, Renna, M, Reusch, Je, Revuelta, Jl, Reyes, L, Rezaie, Ar, Richards, Ri, Richardson, Dr, Richetta, C, Riehle, Ma, Rihn, Bh, Rikihisa, Y, Riley, Be, Rimbach, G, Rippo, Mr, Ritis, K, Rizzi, F, Rizzo, E, Roach, Pj, Robbins, J, Roberge, M, Roca, G, Roccheri, Mc, Rocha, S, Rodrigues, Cm, Rodríguez, Ci, de Cordoba, Sr, Rodriguez Muela, N, Roelofs, J, Rogov, Vv, Rohn, Tt, Rohrer, B, Romanelli, D, Romani, L, Romano, P, Roncero, Mi, Rosa, Jl, Rosello, A, Rosen, Kv, Rosenstiel, P, Rost Roszkowska, M, Roth, Ka, Roué, G, Rouis, M, Rouschop, Km, Ruan, Dt, Ruano, D, Rubinsztein, Dc, Rucker EB, 3rd, Rudich, A, Rudolf, E, Rudolf, R, Ruegg, Ma, Ruiz Roldan, C, Ruparelia, Aa, Rusmini, P, Russ, Dw, Russo, Gl, Russo, G, Russo, R, Rusten, Te, Ryabovol, V, Ryan, Km, Ryter, Sw, Sabatini, Dm, Sacher, M, Sachse, C, Sack, Mn, Sadoshima, J, Saftig, P, Sagi Eisenberg, R, Sahni, S, Saikumar, P, Saito, T, Saitoh, T, Sakakura, K, Sakoh Nakatogawa, M, Sakuraba, Y, Salazar Roa, M, Salomoni, P, Saluja, Ak, Salvaterra, Pm, Salvioli, R, Samali, A, Sanchez, Am, Sánchez Alcázar, Ja, Sanchez Prieto, R, Sandri, M, Sanjuan, Ma, Santaguida, S, Santambrogio, L, Santoni, G, Dos Santos, Cn, Saran, S, Sardiello, M, Sargent, G, Sarkar, P, Sarkar, S, Sarrias, Mr, Sarwal, Mm, Sasakawa, C, Sasaki, M, Sass, M, Sato, K, Sato, M, Satriano, J, Savaraj, N, Saveljeva, S, Schaefer, L, Schaible, Ue, Scharl, M, Schatzl, Hm, Schekman, R, Scheper, W, Schiavi, A, Schipper, Hm, Schmeisser, H, Schmidt, J, Schmitz, I, Schneider, Be, Schneider, Em, Schneider, Jl, Schon, Ea, Schönenberger, Mj, Schönthal, Ah, Schorderet, Df, Schröder, B, Schuck, S, Schulze, Rj, Schwarten, M, Schwarz, Tl, Sciarretta, S, Scotto, K, Scovassi, Ai, Screaton, Ra, Screen, M, Seca, H, Sedej, S, Segatori, L, Segev, N, Seglen, Po, Seguí Simarro, Jm, Segura Aguilar, J, Seki, E, Sell, C, Selliez, I, Semenkovich, Cf, Semenza, Gl, Sen, U, Serra, Al, Serrano Puebla, A, Sesaki, H, Setoguchi, T, Settembre, C, Shacka, Jj, Shajahan Haq, An, Shapiro, Im, Sharma, S, She, H, Shen, Cj, Shen, Cc, Shen, Hm, Shen, S, Shen, W, Sheng, R, Sheng, X, Sheng, Zh, Shepherd, Tg, Shi, J, Shi, Q, Shi, Y, Shibutani, S, Shibuya, K, Shidoji, Y, Shieh, Jj, Shih, Cm, Shimada, Y, Shimizu, S, Shin, Dw, Shinohara, Ml, Shintani, M, Shintani, T, Shioi, T, Shirabe, K, Shiri Sverdlov, R, Shirihai, O, Shore, Gc, Shu, Cw, Shukla, D, Sibirny, Aa, Sica, V, Sigurdson, Cj, Sigurdsson, Em, Sijwali, P, Sikorska, B, Silveira, Wa, Silvente Poirot, S, Silverman, Ga, Simak, J, Simmet, T, Simon, Ak, Simon, Hu, Simone, C, Simons, M, Simonsen, A, Singh, R, Singh, Sv, Singh, Sk, Sinha, D, Sinha, S, Sinicrope, Fa, Sirko, A, Sirohi, K, Sishi, Bj, Sittler, A, Siu, Pm, Sivridis, E, Skwarska, A, Slack, R, Slaninová, I, Slavov, N, Smaili, S, Smalley, K, Smith, Dr, Soenen, Sj, Soleimanpour, Sa, Solhaug, A, Somasundaram, K, Son, Jh, Sonawane, A, Song, C, Song, F, Song, Hk, Song, Jx, Song, W, Soo, Ky, Sood, Ak, Soong, Tw, Soontornniyomkij, V, Sorice, M, Sotgia, F, Soto Pantoja, Dr, Sotthibundhu, A, Sousa, Mj, Spaink, Hp, Span, Pn, Spang, A, Sparks, Jd, Speck, Pg, Spector, Sa, Spies, Cd, Springer, W, Clair, D, Stacchiotti, A, Staels, B, Stang, Mt, Starczynowski, Dt, Starokadomskyy, P, Steegborn, C, Steele, Jw, Stefanis, L, Steffan, J, Stellrecht, Cm, Stenmark, H, Stepkowski, Tm, Stern, St, Stevens, C, Stockwell, Br, Stoka, V, Storchova, Z, Stork, B, Stratoulias, V, Stravopodis, Dj, Strnad, P, Strohecker, Am, Ström, Al, Stromhaug, P, Stulik, J, Su, Yx, Su, Z, Subauste, C, Subramaniam, S, Sue, Cm, Suh, Sw, Sui, X, Sukseree, S, Sulzer, D, Sun, Fl, Sun, J, Sun, Sy, Sun, Y, Sundaramoorthy, V, Sung, J, Suzuki, H, Suzuki, K, Suzuki, N, Suzuki, T, Suzuki, Yj, Swanson, M, Swanton, C, Swärd, K, Swarup, G, Sweeney, St, Sylvester, Pw, Szatmari, Z, Szegezdi, E, Szlosarek, Pw, Taegtmeyer, H, Tafani, M, Taillebourg, E, Tait, Sw, Takacs Vellai, K, Takahashi, Y, Takáts, S, Takemura, G, Takigawa, N, Talbot, Nj, Tamagno, E, Tamburini, J, Tan, Cp, Tan, L, Tan, Ml, Tan, M, Tan, Yj, Tanaka, K, Tanaka, M, Tang, D, Tang, G, Tanida, I, Tanji, K, Tannous, Ba, Tapia, Ja, Tasset Cuevas, I, Tatar, M, Tavassoly, I, Tavernarakis, N, Taylor, A, Taylor, G, Taylor, Ga, Taylor, Jp, Taylor, Mj, Tchetina, Ev, Tee, Ar, Teixeira Clerc, F, Telang, S, Tencomnao, T, Teng, Bb, Teng, Rj, Terro, F, Tettamanti, G, Theiss, Al, Theron, Ae, Thomas, Kj, Thomé, Mp, Thomes, Pg, Thorburn, A, Thorner, J, Thum, T, Thumm, M, Thurston, Tl, Tian, L, Till, A, Ting, Jp, Titorenko, Vi, Toker, L, Toldo, S, Tooze, Sa, Topisirovic, I, Torgersen, Ml, Torosantucci, L, Torriglia, A, Torrisi, Mr, Tournier, C, Towns, R, Trajkovic, V, Travassos, Lh, Triola, G, Tripathi, Dn, Trisciuoglio, D, Troncoso, R, Trougakos, Ip, Truttmann, Ac, Tsai, Kj, Tschan, Mp, Tseng, Yh, Tsukuba, T, Tsung, A, Tsvetkov, A, Tu, S, Tuan, Hy, Tucci, M, Tumbarello, Da, Turk, B, Turk, V, Turner, Rf, Tveita, Aa, Tyagi, Sc, Ubukata, M, Uchiyama, Y, Udelnow, A, Ueno, T, Umekawa, M, Umemiya Shirafuji, R, Underwood, Br, Ungermann, C, Ureshino, Rp, Ushioda, R, Uversky, Vn, Uzcátegui, Nl, Vaccari, T, Vaccaro, Mi, Váchová, L, Vakifahmetoglu Norberg, H, Valdor, R, Valente, Em, Vallette, F, Valverde, Am, Van den Berghe, G, Van Den Bosch, L, van den Brink, Gr, van der Goot, Fg, van der Klei, Ij, van der Laan, Lj, van Doorn, Wg, van Egmond, M, van Golen, Kl, Van Kaer, L, van Lookeren Campagne, M, Vandenabeele, P, Vandenberghe, W, Vanhorebeek, I, Varela Nieto, I, Vasconcelos, Mh, Vasko, R, Vavvas, Dg, Vega Naredo, I, Velasco, G, Velentzas, Ad, Velentzas, Pd, Vellai, T, Vellenga, E, Vendelbo, Mh, Venkatachalam, K, Ventura, N, Ventura, S, Veras, P, Verdier, M, Vertessy, Bg, Viale, A, Vidal, M, Vieira, H, Vierstra, Rd, Vigneswaran, N, Vij, N, Vila, M, Villar, M, Villar, Vh, Villarroya, J, Vindis, C, Viola, G, Viscomi, Mt, Vitale, G, Vogl, Dt, Voitsekhovskaja, Ov, von Haefen, C, von Schwarzenberg, K, Voth, De, Vouret Craviari, V, Vuori, K, Vyas, Jm, Waeber, C, Walker, Cl, Walker, Mj, Walter, J, Wan, L, Wan, X, Wang, B, Wang, C, Wang, Cy, Wang, D, Wang, F, Wang, G, Wang, Hj, Wang, H, Wang, Hg, Wang, Hd, Wang, J, Wang, M, Wang, Mq, Wang, Py, Wang, P, Wang, Rc, Wang, S, Wang, Tf, Wang, X, Wang, Xj, Wang, Xw, Wang, Y, Wang, Yj, Wang, Yt, Wang, Zn, Wappner, P, Ward, C, Ward, Dm, Warnes, G, Watada, H, Watanabe, Y, Watase, K, Weaver, Te, Weekes, Cd, Wei, J, Weide, T, Weihl, Cc, Weindl, G, Weis, Sn, Wen, L, Wen, X, Wen, Y, Westermann, B, Weyand, Cm, White, Ar, White, E, Whitton, Jl, Whitworth, Aj, Wiels, J, Wild, F, Wildenberg, Me, Wileman, T, Wilkinson, D, Wilkinson, S, Willbold, D, Williams, C, Williams, K, Williamson, Pr, Winklhofer, Kf, Witkin, S, Wohlgemuth, Se, Wollert, T, Wolvetang, Ej, Wong, E, Wong, Gw, Wong, Rw, Wong, Vk, Woodcock, Ea, Wright, Kl, Wu, C, Wu, D, Wu, G, Wu, J, Wu, M, Wu, S, Wu, Wk, Wu, Y, Wu, Z, Xavier, Cp, Xavier, Rj, Xia, Gx, Xia, T, Xia, W, Xia, Y, Xiao, H, Xiao, J, Xiao, S, Xiao, W, Xie, Cm, Xie, Z, Xilouri, M, Xiong, Y, Xu, C, Xu, F, Xu, H, Xu, J, Xu, L, Xu, X, Xu, Y, Xu, Zx, Xu, Z, Xue, Y, Yamada, T, Yamamoto, A, Yamanaka, K, Yamashina, S, Yamashiro, S, Yan, B, Yan, X, Yan, Z, Yanagi, Y, Yang, D, Yang, Jm, Yang, L, Yang, M, Yang, Pm, Yang, P, Yang, Q, Yang, W, Yang, Wy, Yang, X, Yang, Y, Yang, Z, Yao, Mc, Yao, Pj, Yao, X, Yao, Z, Yasui, L, Ye, M, Yedvobnick, B, Yeganeh, B, Yeh, E, Yeyati, Pl, Yi, F, Yi, L, Yin, Xm, Yip, Ck, Yoo, Ym, Yoo, Yh, Yoon, Sy, Yoshida, Ki, Yoshimori, T, Young, Kh, Yu, H, Yu, Jj, Yu, Jt, Yu, J, Yu, L, Yu, Wh, Yu, Xf, Yu, Z, Yuan, J, Yuan, Zm, Yue, By, Yue, J, Yue, Z, Zacks, Dn, Zacksenhaus, E, Zaffaroni, N, Zaglia, T, Zakeri, Z, Zecchini, V, Zeng, J, Zeng, M, Zeng, Q, Zervos, A, Zhang, Dd, Zhang, F, Zhang, G, Zhang, Gc, Zhang, H, Zhang, J, Zhang, Jp, Zhang, L, Zhang, My, Zhang, X, Zhang, Xd, Zhang, Y, Zhao, M, Zhao, Wl, Zhao, X, Zhao, Yg, Zhao, Y, Zhao, Yx, Zhao, Z, Zhao, Zj, Zheng, D, Zheng, Xl, Zheng, X, Zhivotovsky, B, Zhong, Q, Zhou, Gz, Zhou, G, Zhou, H, Zhou, Sf, Zhou, Xj, Zhu, H, Zhu, Wg, Zhu, W, Zhu, Xf, Zhu, Y, Zhuang, Sm, Zhuang, X, Ziparo, E, Zois, Ce, Zoladek, T, Zong, Wx, Zorzano, A, Zughaier, Sm, AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, Other departments, CCA -Cancer Center Amsterdam, Center of Experimental and Molecular Medicine, Radiotherapy, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, ANS - Cellular & Molecular Mechanisms, Cell Biology and Histology, Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adam, Peter D Adam, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostini, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez- Erviti, Sandro Alve, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu- Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Aria, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askana, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong- Hun Bae, Jae-sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast Jr, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R. Beck Jr, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrend, Georg MN Behren, Kevin E Behrn, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Be, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Bille, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boe, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie- Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H Brau, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridge, MarieAgnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brooke, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwell, Monika Cahova, Dongsheng Cai, Jingjing Cai, Qian Cai, Sara Calatayud, Nadine Camougrand, Michelangelo Campanella, Grant R Campbell, Matthew Campbell, Silvia Campello, Robin Candau, Isabella Caniggia, Lavinia Cantoni, Lizhi Cao, Allan B Caplan, Michele Caraglia, Claudio Cardinali, Sandra Morais Cardoso, Jennifer S Carew, Laura A Carleton, Cathleen R Carlin, Silvia Carloni, Sven R Carlsson, Didac Carmona-Gutierrez, Leticia AM Carneiro, Oliana Carnevali, Serena Carra, Alice Carrier, Bernadette Carroll, Caty Casa, Josefina Casa, Giuliana Cassinelli, Perrine Castet, Susana Castro-Obregon, Gabriella Cavallini, Isabella Ceccherini, Francesco Cecconi, Arthur I Cederbaum, Valentín Ceña, Simone Cenci, Claudia Cerella, Davide Cervia, Silvia Cetrullo, Hassan Chaachouay, Han-Jung Chae, Andrei S Chagin, Chee-Yin Chai, Gopal Chakrabarti, Georgios Chamilo, Edmond YW Chan, Matthew TV Chan, Dhyan Chandra, Pallavi Chandra, Chih-Peng Chang, Raymond Chuen-Chung Chang, Ta Yuan Chang, John C Chatham, Saurabh Chatterjee, Santosh Chauhan, Yongsheng Che, Michael E Cheetham, Rajkumar Cheluvappa, Chun-Jung Chen, Gang Chen, Guang-Chao Chen, Guoqiang Chen, Hongzhuan Chen, Jeff W Chen, Jian-Kang Chen, Min Chen, Mingzhou Chen, Peiwen Chen, Qi Chen, Quan Chen, Shang- Der Chen, Si Chen, Steve S-L Chen, Wei Chen, Wei-Jung Chen, Wen Qiang Chen, Wenli Chen, Xiangmei Chen, Yau-Hung Chen, Ye-Guang Chen, Yin Chen, Yingyu Chen, Yongshun Chen, Yu- Jen Chen, Yue-Qin Chen, Yujie Chen, Zhen Chen, Zhong Chen, Alan Cheng, Christopher HK Cheng, Hua Cheng, Heesun Cheong, Sara Cherry, Jason Chesney, Chun Hei Antonio Cheung, Eric Chevet, Hsiang Cheng Chi, Sung-Gil Chi, Fulvio Chiacchiera, Hui-Ling Chiang, Roberto Chiarelli, Mario Chiariello, Marcello Chieppa, Lih-Shen Chin, Mario Chiong, Gigi NC Chiu, Dong-Hyung Cho, Ssang-Goo Cho, William C Cho, Yong-Yeon Cho, Young-Seok Cho, Augustine MK Choi, Eui-Ju Choi, Eun-Kyoung Choi, Jayoung Choi, Mary E Choi, Seung-Il Choi, Tsui-Fen Chou, Salem Chouaib, Divaker Choubey, Vinay Choubey, Kuan-Chih Chow, Kamal Chowdhury, Charleen T Chu, Tsung-Hsien Chuang, Taehoon Chun, Hyewon Chung, Taijoon Chung, Yuen-Li Chung, Yong-Joon Chwae, Valentina Cianfanelli, Roberto Ciarcia, Iwona A Ciechomska, Maria Rosa Ciriolo, Mara Cirone, Sofie Claerhout, Michael J Clague, Joan Clària, Peter GH Clarke, Robert Clarke, Emilio Clementi, Cédric Cleyrat, Miriam Cnop, Eliana M Coccia, Tiziana Cocco, Patrice Codogno, Jörn Coer, Ezra EW Cohen, David Colecchia, Luisa Coletto, Núria S Coll, Emma Colucci-Guyon, Sergio Comincini, Maria Condello, Katherine L Cook, Graham H Coomb, Cynthia D Cooper, J Mark Cooper, Isabelle Coppen, Maria Tiziana Corasaniti, Marco Corazzari, Ramon Corbalan, Elisabeth Corcelle-Termeau, Mario D Cordero, Cristina Corral-Ramo, Olga Corti, Andrea Cossarizza, Paola Costelli, Safia Coste, Susan L Cotman, Ana Coto-Monte, Sandra Cottet, Eduardo Couve, Lori R Covey, L Ashley Cowart, Jeffery S Cox, Fraser P Coxon, Carolyn B Coyne, Mark S Cragg, Rolf J Craven, Tiziana Crepaldi, Jose L Crespo, Alfredo Criollo, Valeria Crippa, Maria Teresa Cruz, Ana Maria Cuervo, Jose M Cuezva, Taixing Cui, Pedro R Cutilla, Mark J Czaja, Maria F Czyzyk-Krzeska, Ruben K Dagda, Uta Dahmen, Chunsun Dai, Wenjie Dai, Yun Dai, Kevin N Dalby, Luisa Dalla Valle, Guillaume Dalmasso, Marcello D'Amelio, Markus Damme, Arlette Darfeuille-Michaud, Catherine Dargemont, Victor M Darley-Usmar, Srinivasan Dasarathy, Biplab Dasgupta, Srikanta Dash, Crispin R Da, Hazel Marie Davey, Lester M David, David Dávila, Roger J Davi, Ted M Dawson, Valina L Dawson, Paula Daza, Jackie de Belleroche, Paul de Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, José de la Fuente, Luisa De Martino, Antonella De Mattei, Guido RY De Meyer, Angelo De Milito, Mauro De Santi, Wanderley de Souza, Vincenzo De Tata, Daniela De Zio, Jayanta Debnath, Reinhard Dechant, Jean-Paul Decuypere, Shane Deegan, Benjamin Dehay, Barbara Del Bello, Dominic P Del Re, Régis Delage-Mourroux, Lea MD Delbridge, Louise Deldicque, Elizabeth Delorme-Axford, Yizhen Deng, Joern Dengjel, Melanie Denizot, Paul Dent, Channing J Der, Vojo Deretic, Benoît Derrien, Eric Deutsch, Timothy P Devarenne, Rodney J Devenish, Sabrina Di Bartolomeo, Nicola Di Daniele, Fabio Di Domenico, Alessia Di Nardo, Simone Di Paola, Antonio Di Pietro, Livia Di Renzo, Aaron DiAntonio, Guillermo Díaz-Araya, Ines Díaz-Laviada, Maria T Diaz-Meco, Javier Diaz-Nido, Chad A Dickey, Robert C Dickson, Marc Diederich, Paul Digard, Ivan Dikic, Savithrama P Dinesh-Kumar, Chan Ding, Wen-Xing Ding, Zufeng Ding, Luciana Dini, Jörg HW Distler, Abhinav Diwan, Mojgan Djavaheri-Mergny, Kostyantyn Dmytruk, Renwick CJ Dobson, Volker Doetsch, Karol Dokladny, Svetlana Dokudovskaya, Massimo Donadelli, X Charlie Dong, Xiaonan Dong, Zheng Dong, Terrence M Donohue Jr, Kelly S Doran, Gabriella D'Orazi, Gerald W Dorn II, Victor Dosenko, Sami Dridi, Liat Drucker, Jie Du, Li-Lin Du, Lihuan Du, André du Toit, Priyamvada Dua, Lei Duan, Pu Duann, Vikash Kumar Dubey, Michael R Duchen, Michel A Duchosal, Helene Duez, Isabelle Dugail, Verónica I Dumit, Mara C Duncan, Elaine A Dunlop, William A Dunn Jr, Nicolas Dupont, Luc Dupui, Raúl V Durán, Thomas M Durcan, Stéphane Duvezin-Caubet, Umamaheswar Duvvuri, Vinay Eapen, Darius Ebrahimi-Fakhari, Arnaud Echard, Leopold Eckhart, Charles L Edelstein, Aimee L Edinger, Ludwig Eichinger, Tobias Eisenberg, Avital Eisenberg-Lerner, N Tony Eissa, Wafik S El-Deiry, Victoria El-Khoury, Zvulun Elazar, Hagit Eldar-Finkelman, Chris JH Elliott, Enzo Emanuele, Urban Emmenegger, Nikolai Engedal, Anna-Mart Engelbrecht, Simone Engelender, Jorrit M Enserink, Ralf Erdmann, Jekaterina Erenpreisa, Rajaraman Eri, Jason L Eriksen, Andreja Erman, Ricardo Escalante, Eeva- Liisa Eskelinen, Lucile Espert, Lorena Esteban-Martínez, Thomas J Evan, Mario Fabri, Gemma Fabria, Cinzia Fabrizi, Antonio Facchiano, Nils J Færgeman, Alberto Faggioni, W Douglas Fairlie, Chunhai Fan, Daping Fan, Jie Fan, Shengyun Fang, Manolis Fanto, Alessandro Fanzani, Thomas Farka, Mathias Faure, Francois B Favier, Howard Fearnhead, Massimo Federici, Erkang Fei, Tania C Felizardo, Hua Feng, Yibin Feng, Yuchen Feng, Thomas A Ferguson, Álvaro F Fernández, Maite G Fernandez-Barrena, Jose C Fernandez-Checa, Arsenio Fernández-López, Martin E Fernandez-Zapico, Olivier Feron, Elisabetta Ferraro, Carmen Veríssima Ferreira-Halder, Laszlo Fesu, Ralph Feuer, Fabienne C Fiesel, Eduardo C Filippi-Chiela, Giuseppe Filomeni, Gian Maria Fimia, John H Fingert, Steven Finkbeiner, Toren Finkel, Filomena Fiorito, Paul B Fisher, Marc Flajolet, Flavio Flamigni, Oliver Florey, Salvatore Florio, R Andres Floto, Marco Folini, Carlo Follo, Edward A Fon, Francesco Fornai, Franco Fortunato, Alessandro Fraldi, Rodrigo Franco, Arnaud Francoi, Aurélie Françoi, Lisa B Frankel, Iain DC Fraser, Norbert Frey, Damien G Freyssenet, Christian Frezza, Scott L Friedman, Daniel E Frigo, Dongxu Fu, José M Fuente, Juan Fueyo, Yoshio Fujitani, Yuuki Fujiwara, Mikihiro Fujiya, Mitsunori Fukuda, Simone Fulda, Carmela Fusco, Bozena Gabryel, Matthias Gaestel, Philippe Gailly, Malgorzata Gajewska, Sehamuddin Galadari, Gad Galili, Inmaculada Galindo, Maria F Galindo, Giovanna Galliciotti, Lorenzo Galluzzi, Luca Galluzzi, Vincent Galy, Noor Gammoh, Sam Gandy, Anand K Ganesan, Swamynathan Ganesan, Ian G Ganley, Monique Gannagé, Fen-Biao Gao, Feng Gao, Jian-Xin Gao, Lorena García Nannig, Eleonora García Véscovi, Marina Garcia-Macía, Carmen Garcia- Ruiz, Abhishek D Garg, Pramod Kumar Garg, Ricardo Gargini, Nils Christian Gassen, Damián Gatica, Evelina Gatti, Julie Gavard, Evripidis Gavathioti, Liang Ge, Pengfei Ge, Shengfang Ge, Po-Wu Gean, Vania Gelmetti, Armando A Genazzani, Jiefei Geng, Pascal Genschik, Lisa Gerner, Jason E Gestwicki, David A Gewirtz, Saeid Ghavami, Eric Ghigo, Debabrata Ghosh, Anna Maria Giammarioli, Francesca Giampieri, Claudia Giampietri, Alexandra Giatromanolaki, Derrick J Gibbing, Lara Gibellini, Spencer B Gibson, Vanessa Ginet, Antonio Giordano, Flaviano Giorgini, Elisa Giovannetti, Stephen E Girardin, Suzana Gispert, Sandy Giuliano, Candece L Gladson, Alvaro Glavic, Martin Gleave, Nelly Godefroy, Robert M Gogal Jr, Kuppan Gokulan, Gustavo H Goldman, Delia Goletti, Michael S Goligorsky, Aldrin V Gome, Ligia C Gome, Hernando Gomez, Candelaria Gomez-Manzano, Rubén Gómez-Sánchez, Dawit AP Gonçalve, Ebru Goncu, Qingqiu Gong, Céline Gongora, Carlos B Gonzalez, Pedro Gonzalez-Alegre, Pilar Gonzalez-Cabo, Rosa Ana González-Polo, Ing Swie Goping, Carlos Gorbea, Nikolai V Gorbunov, Daphne R Goring, Adrienne M Gorman, Sharon M Gorski, Sandro Goruppi, Shino Goto- Yamada, Cecilia Gotor, Roberta A Gottlieb, Illana Goze, Devrim Gozuacik, Yacine Graba, Martin Graef, Giovanna E Granato, Gary Dean Grant, Steven Grant, Giovanni Luca Gravina, Douglas R Green, Alexander Greenhough, Michael T Greenwood, Benedetto Grimaldi, Frédéric Gro, Charles Grose, Jean-Francois Groulx, Florian Gruber, Paolo Grumati, Tilman Grune, Jun-Lin Guan, Kun-Liang Guan, Barbara Guerra, Carlos Guillen, Kailash Gulshan, Jan Gunst, Chuanyong Guo, Lei Guo, Ming Guo, Wenjie Guo, Xu-Guang Guo, Andrea A Gust, Åsa B Gustafsson, Elaine Gutierrez, Maximiliano G Gutierrez, Ho-Shin Gwak, Albert Haa, James E Haber, Shinji Hadano, Monica Hagedorn, David R Hahn, Andrew J Halayko, Anne Hamacher-Brady, Kozo Hamada, Ahmed Hamai, Andrea Hamann, Maho Hamasaki, Isabelle Hamer, Qutayba Hamid, Ester M Hammond, Feng Han, Weidong Han, James T Handa, John A Hanover, Malene Hansen, Masaru Harada, Ljubica Harhaji-Trajkovic, J Wade Harper, Abdel Halim Harrath, Adrian L Harri, James Harri, Udo Hasler, Peter Hasselblatt, Kazuhisa Hasui, Robert G Hawley, Teresa S Hawley, Congcong He, Cynthia Y He, Fengtian He, Gu He, Rong-Rong He, Xian-Hui He, You-Wen He, Yu- Ying He, Joan K Heath, Marie-Josée Hébert, Robert A Heinzen, Gudmundur Vignir Helgason, Michael Hensel, Elizabeth P Henske, Chengtao Her, Paul K Herman, Agustín Hernández, Carlos Hernandez, Sonia Hernández-Tiedra, Claudio Hetz, P Robin Hiesinger, Katsumi Higaki, Sabine Hilfiker, Bradford G Hill, Joseph A Hill, William D Hill, Keisuke Hino, Daniel Hofiu, Paul Hofman, Günter U Höglinger, Jörg Höhfeld, Marina K Holz, Yonggeun Hong, David A Hood, Jeroen JM Hoozeman, Thorsten Hoppe, Chin Hsu, Chin-Yuan Hsu, Li-Chung Hsu, Dong Hu, Guochang Hu, Hong-Ming Hu, Hongbo Hu, Ming Chang Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Ya Hua, Canhua Huang, Huey-Lan Huang, Kuo-How Huang, Kuo-Yang Huang, Shile Huang, Shiqian Huang, Wei-Pang Huang, Yi-Ran Huang, Yong Huang, Yunfei Huang, Tobias B Huber, Patricia Huebbe, Won-Ki Huh, Juha J Hulmi, Gang Min Hur, James H Hurley, Zvenyslava Husak, Sabah NA Hussain, Salik Hussain, Jung Jin Hwang, Seungmin Hwang, Thomas IS Hwang, Atsuhiro Ichihara, Yuzuru Imai, Carol Imbriano, Megumi Inomata, Takeshi Into, Valentina Iovane, Juan L Iovanna, Renato V Iozzo, Nancy Y Ip, Javier E Irazoqui, Pablo Iribarren, Yoshitaka Isaka, Aleksandra J Isakovic, Harry Ischiropoulo, Jeffrey S Isenberg, Mohammad Ishaq, Hiroyuki Ishida, Isao Ishii, Jane E Ishmael, Ciro Isidoro, Ken-ichi Isobe, Erika Isono, Shohreh Issazadeh- Navika, Koji Itahana, Eisuke Itakura, Andrei I Ivanov, Anand Krishnan V Iyer, José M Izquierdo, Yotaro Izumi, Valentina Izzo, Marja Jäättelä, Nadia Jaber, Daniel John Jackson, William T Jackson, Tony George Jacob, Thomas S Jacque, Chinnaswamy Jagannath, Ashish Jain, Nihar Ranjan Jana, Byoung Kuk Jang, Alkesh Jani, Bassam Janji, Paulo Roberto Jannig, Patric J Jansson, Steve Jean, Marina Jendrach, Ju-Hong Jeon, Niels Jessen, Eui-Bae Jeung, Kailiang Jia, Lijun Jia, Hong Jiang, Hongchi Jiang, Liwen Jiang, Teng Jiang, Xiaoyan Jiang, Xuejun Jiang, Ying Jiang, Yongjun Jiang, Alberto Jiménez, Cheng Jin, Hongchuan Jin, Lei Jin, Meiyan Jin, Shengkan Jin, Umesh Kumar Jinwal, Eun-Kyeong Jo, Terje Johansen, Daniel E Johnson, Gail VW Johnson, James D Johnson, Eric Jonasch, Chris Jone, Leo AB Joosten, Joaquin Jordan, Anna-Maria Joseph, Bertrand Joseph, Annie M Joubert, Dianwen Ju, Jingfang Ju, Hsueh-Fen Juan, Katrin Juenemann, Gábor Juhász, Hye Seung Jung, Jae U Jung, Yong-Keun Jung, Heinz Jungbluth, Matthew J Justice, Barry Jutten, Nadeem O Kaakoush, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Bertrand Kaeffer, Katarina Kågedal, Alon Kahana, Shingo Kajimura, Or Kakhlon, Manjula Kalia, Dhan V Kalvakolanu, Yoshiaki Kamada, Konstantinos Kamba, Vitaliy O Kaminskyy, Harm H Kampinga, Mustapha Kandouz, Chanhee Kang, Rui Kang, Tae-Cheon Kang, Tomotake Kanki, Thirumala- Devi Kanneganti, Haruo Kanno, Anumantha G Kanthasamy, Marc Kantorow, Maria Kaparakis- Liasko, Orsolya Kapuy, Vassiliki Karantza, Md Razaul Karim, Parimal Karmakar, Arthur Kaser, Susmita Kaushik, Thomas Kawula, A Murat Kaynar, Po-Yuan Ke, Zun-Ji Ke, John H Kehrl, Kate E Keller, Jongsook Kim Kemper, Anne K Kenworthy, Oliver Kepp, Andreas Kern, Santosh Kesari, David Kessel, Robin Ketteler, Isis do Carmo Kettelhut, Bilon Khambu, Muzamil Majid Khan, Vinoth KM Khandelwal, Sangeeta Khare, Juliann G Kiang, Amy A Kiger, Akio Kihara, Arianna L Kim, Cheol Hyeon Kim, Deok Ryong Kim, Do-Hyung Kim, Eung Kweon Kim, Hye Young Kim, Hyung-Ryong Kim, Jae-Sung Kim, Jeong Hun Kim, Jin Cheon Kim, Jin Hyoung Kim, Kwang Woon Kim, Michael D Kim, Moon-Moo Kim, Peter K Kim, Seong Who Kim, Soo-Youl Kim, Yong-Sun Kim, Yonghyun Kim, Adi Kimchi, Alec C Kimmelman, Tomonori Kimura, Jason S King, Karla Kirkegaard, Vladimir Kirkin, Lorrie A Kirshenbaum, Shuji Kishi, Yasuo Kitajima, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Rudolf A Kley, Walter T Klimecki, Michael Klinkenberg, Jochen Klucken, Helene Knævelsrud, Erwin Knecht, Laura Knuppertz, Jiunn-Liang Ko, Satoru Kobayashi, Jan C Koch, Christelle Koechlin-Ramonatxo, Ulrich Koenig, Young Ho Koh, Katja Köhler, Sepp D Kohlwein, Masato Koike, Masaaki Komatsu, Eiki Kominami, Dexin Kong, Hee Jeong Kong, Eumorphia G Konstantakou, Benjamin T Kopp, Tamas Korcsmaro, Laura Korhonen, Viktor I Korolchuk, Nadya V Koshkina, Yanjun Kou, Michael I Koukouraki, Constantinos Koumeni, Attila L Kovác, Tibor Kovác, Werner J Kovac, Daisuke Koya, Claudine Kraft, Dimitri Krainc, Helmut Kramer, Tamara Kravic-Stevovic, Wilhelm Krek, Carole Kretz-Remy, Roswitha Krick, Malathi Krishnamurthy, Janos Kriston-Vizi, Guido Kroemer, Michael C Kruer, Rejko Kruger, Nicholas T Ktistaki, Kazuyuki Kuchitsu, Christian Kuhn, Addanki Pratap Kumar, Anuj Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Rakesh Kumar, Sharad Kumar, Mondira Kundu, Hsing-Jien Kung, Atsushi Kuno, Sheng-Han Kuo, Jeff Kuret, Tino Kurz, Terry Kwok, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert R La Spada, Frank Lafont, Tim Lahm, Aparna Lakkaraju, Truong Lam, Trond Lamark, Steve Lancel, Terry H Landowski, Darius JR Lane, Jon D Lane, Cinzia Lanzi, Pierre Lapaquette, Louis R Lapierre, Jocelyn Laporte, Johanna Laukkarinen, Gordon W Laurie, Sergio Lavandero, Lena Lavie, Matthew J LaVoie, Betty Yuen Kwan Law, Helen Ka-wai Law, Kelsey B Law, Robert Layfield, Pedro A Lazo, Laurent Le Cam, Karine G Le Roch, Hervé Le Stunff, Vijittra Leardkamolkarn, Marc Lecuit, Byung-Hoon Lee, Che- Hsin Lee, Erinna F Lee, Gyun Min Lee, He-Jin Lee, Hsinyu Lee, Jae Keun Lee, Jongdae Lee, Juhyun Lee, Jun Hee Lee, Michael Lee, Myung-Shik Lee, Patty J Lee, Sam W Lee, Seung-Jae Lee, Shiow-Ju Lee, Stella Y Lee, Sug Hyung Lee, Sung Sik Lee, Sung-Joon Lee, Sunhee Lee, Ying- Ray Lee, Yong J Lee, Young H Lee, Christiaan Leeuwenburgh, Sylvain Lefort, Renaud Legoui, Jinzhi Lei, Qun-Ying Lei, David A Leib, Gil Leibowitz, Istvan Lekli, Stéphane D Lemaire, John J Lemaster, Marius K Lemberg, Antoinette Lemoine, Shuilong Leng, Guido Lenz, Paola Lenzi, Lilach O Lerman, Daniele Lettieri Barbato, Julia I-Ju Leu, Hing Y Leung, Beth Levine, Patrick A Lewi, Frank Lezoualc'h, Chi Li, Faqiang Li, Feng-Jun Li, Jun Li, Ke Li, Lian Li, Min Li, Qiang Li, Rui Li, Sheng Li, Wei Li, Xiaotao Li, Yumin Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Yulin Liao, Joana Liberal, Pawel P Liberski, Pearl Lie, Andrew P Lieberman, Hyunjung Jade Lim, Kah-Leong Lim, Kyu Lim, Raquel T Lima, Chang-Shen Lin, Chiou-Feng Lin, Fang Lin, Fangming Lin, Fu-Cheng Lin, Kui Lin, Kwang-Huei Lin, Pei-Hui Lin, Tianwei Lin, Wan-Wan Lin, Yee-Shin Lin, Yong Lin, Rafael Linden, Dan Lindholm, Lisa M Lindqvist, Paul Lingor, Andreas Linkermann, Lance A Liotta, Marta M Lipinski, Vitor A Lira, Michael P Lisanti, Paloma B Liton, Bo Liu, Chong Liu, Chun-Feng Liu, Fei Liu, Hung-Jen Liu, Jianxun Liu, Jing-Jing Liu, Jing-Lan Liu, Ke Liu, Leyuan Liu, Liang Liu, Quentin Liu, Rong-Yu Liu, Shiming Liu, Shuwen Liu, Wei Liu, Xian-De Liu, Xiangguo Liu, Xiao-Hong Liu, Xinfeng Liu, Xu Liu, Xueqin Liu, Yang Liu, Yule Liu, Zexian Liu, Zhe Liu, Juan P Liuzzi, Gérard Lizard, Mila Ljujic, Irfan J Lodhi, Susan E Logue, Bal L Lokeshwar, Yun Chau Long, Sagar Lonial, Benjamin Loo, Carlos López-Otín, Cristina López-Vicario, Mar Lorente, Philip L Lorenzi, Péter Lõrincz, Marek Lo, Michael T Lotze, Penny E Lovat, Binfeng Lu, Bo Lu, Jiahong Lu, Qing Lu, She-Min Lu, Shuyan Lu, Yingying Lu, Frédéric Luciano, Shirley Luckhart, John Milton Lucocq, Paula Ludovico, Aurelia Lugea, Nicholas W Lukac, Julian J Lum, Anders H Lund, Honglin Luo, Jia Luo, Shouqing Luo, Claudio Luparello, Timothy Lyon, Jianjie Ma, Yi Ma, Yong Ma, Zhenyi Ma, Juliano Machado, Glaucia M Machado-Santelli, Fernando Macian, Gustavo C MacIntosh, Jeffrey P MacKeigan, Kay F Macleod, John D MacMicking, Lee Ann MacMillan-Crow, Frank Madeo, Muniswamy Madesh, Julio Madrigal-Matute, Akiko Maeda, Tatsuya Maeda, Gustavo Maegawa, Emilia Maellaro, Hannelore Mae, Marta Magariño, Kenneth Maiese, Tapas K Maiti, Luigi Maiuri, Maria Chiara Maiuri, Carl G Maki, Roland Malli, Walter Malorni, Alina Maloyan, Fathia Mami-Chouaib, Na Man, Joseph D Mancia, Eva-Maria Mandelkow, Michael A Mandell, Angelo A Manfredi, Serge N Manié, Claudia Manzoni, Kai Mao, Zixu Mao, Zong-Wan Mao, Philippe Marambaud, Anna Maria Marconi, Zvonimir Marelja, Gabriella Marfe, Marta Margeta, Eva Margittai, Muriel Mari, Francesca V Mariani, Concepcio Marin, Sara Marinelli, Guillermo Mariño, Ivanka Markovic, Rebecca Marquez, Alberto M Martelli, Sascha Marten, Katie R Martin, Seamus J Martin, Shaun Martin, Miguel A Martin- Acebe, Paloma Martín-Sanz, Camille Martinand-Mari, Wim Martinet, Jennifer Martinez, Nuria Martinez-Lopez, Ubaldo Martinez-Outschoorn, Moisés Martínez-Velázquez, Marta Martinez- Vicente, Waleska Kerllen Martin, Hirosato Mashima, James A Mastrianni, Giuseppe Matarese, Paola Matarrese, Roberto Mateo, Satoaki Matoba, Naomichi Matsumoto, Takehiko Matsushita, Akira Matsuura, Takeshi Matsuzawa, Mark P Mattson, Soledad Matu, Norma Maugeri, Caroline Mauvezin, Andreas Mayer, Dusica Maysinger, Guillermo D Mazzolini, Mary Kate McBrayer, Kimberly McCall, Craig McCormick, Gerald M McInerney, Skye C McIver, Sharon McKenna, John J McMahon, Iain A McNeish, Fatima Mechta-Grigoriou, Jan Paul Medema, Diego L Medina, Klara Megyeri, Maryam Mehrpour, Jawahar L Mehta, Yide Mei, Ute-Christiane Meier, Alfred J Meijer, Alicia Meléndez, Gerry Melino, Sonia Melino, Edesio Jose Tenorio de Melo, Maria A Mena, Marc D Meneghini, Javier A Menendez, Regina Meneze, Liesu Meng, Ling-hua Meng, Songshu Meng, Rossella Menghini, A Sue Menko, Rubem FS Menna-Barreto, Manoj B Menon, Marco A Meraz-Río, Giuseppe Merla, Luciano Merlini, Angelica M Merlot, Andreas Meryk, Stefania Meschini, Joel N Meyer, Man-tian Mi, Chao-Yu Miao, Lucia Micale, Simon Michaeli, Carine Michiel, Anna Rita Migliaccio, Anastasia Susie Mihailidou, Dalibor Mijaljica, Katsuhiko Mikoshiba, Enrico Milan, Leonor Miller-Fleming, Gordon B Mill, Ian G Mill, Georgia Minakaki, Berge A Minassian, Xiu-Fen Ming, Farida Minibayeva, Elena A Minina, Justine D Mintern, Saverio Minucci, Antonio Miranda-Vizuete, Claire H Mitchell, Shigeki Miyamoto, Keisuke Miyazawa, Noboru Mizushima, Katarzyna Mnich, Baharia Mograbi, Simin Mohseni, Luis Ferreira Moita, Marco Molinari, Maurizio Molinari, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Marco Mongillo, Martha M Monick, Serena Montagnaro, Craig Montell, Darren J Moore, Michael N Moore, Rodrigo Mora-Rodriguez, Paula I Moreira, Etienne Morel, Maria Beatrice Morelli, Sandra Moreno, Michael J Morgan, Arnaud Mori, Yuji Moriyasu, Janna L Morrison, Lynda A Morrison, Eugenia Morselli, Jorge Moscat, Pope L Moseley, Serge Mostowy, Elisa Motori, Denis Mottet, Jeremy C Mottram, Charbel E-H Moussa, Vassiliki E Mpakou, Hasan Mukhtar, Jean M Mulcahy Levy, Sylviane Muller, Raquel Muñoz-Moreno, Cristina Muñoz-Pinedo, Christian Münz, Maureen E Murphy, James T Murray, Aditya Murthy, Indira U Mysorekar, Ivan R Nabi, Massimo Nabissi, Gustavo A Nader, Yukitoshi Nagahara, Yoshitaka Nagai, Kazuhiro Nagata, Anika Nagelkerke, Péter Nagy, Samisubbu R Naidu, Sreejayan Nair, Hiroyasu Nakano, Hitoshi Nakatogawa, Meera Nanjundan, Gennaro Napolitano, Naweed I Naqvi, Roberta Nardacci, Derek P Narendra, Masashi Narita, Anna Chiara Nascimbeni, Ramesh Natarajan, Luiz C Navegante, Steffan T Nawrocki, Taras Y Nazarko, Volodymyr Y Nazarko, Thomas Neill, Luca M Neri, Mihai G Netea, Romana T Netea-Maier, Bruno M Neve, Paul A Ney, Ioannis P Nezi, Hang TT Nguyen, Huu Phuc Nguyen, Anne-Sophie Nicot, Hilde Nilsen, Per Nilsson, Mikio Nishimura, Ichizo Nishino, Mireia Niso-Santano, Hua Niu, Ralph A Nixon, Vincent CO Njar, Takeshi Noda, Angelika A Noegel, Elsie Magdalena Nolte, Erik Norberg, Koenraad K Norga, Sakineh Kazemi Noureini, Shoji Notomi, Lucia Notterpek, Karin Nowikovsky, Nobuyuki Nukina, Thorsten Nürnberger, Valerie B O'Donnell, Tracey O'Donovan, Peter J O'Dwyer, Ina Oehme, Clara L Oeste, Michinaga Ogawa, Besim Ogretmen, Yuji Ogura, Young J Oh, Masaki Ohmuraya, Takayuki Ohshima, Rani Ojha, Koji Okamoto, Toshiro Okazaki, F Javier Oliver, Karin Ollinger, Stefan Olsson, Daniel P Orban, Paulina Ordonez, Idil Orhon, Laszlo Orosz, Eyleen J O'Rourke, Helena Orozco, Angel L Ortega, Elena Ortona, Laura D Osellame, Junko Oshima, Shigeru Oshima, Heinz D Osiewacz, Takanobu Otomo, Kinya Otsu, Jing-hsiung James Ou, Tiago F Outeiro, Dong-yun Ouyang, Hongjiao Ouyang, Michael Overholtzer, Michelle A Ozbun, P Hande Ozdinler, Bulent Ozpolat, Consiglia Pacelli, Paolo Paganetti, Guylène Page, Gilles Page, Ugo Pagnini, Beata Pajak, Stephen C Pak, Karolina Pakos-Zebrucka, Nazzy Pakpour, Zdena Palková, Francesca Palladino, Kathrin Pallauf, Nicolas Pallet, Marta Palmieri, Søren R Paludan, Camilla Palumbo, Silvia Palumbo, Olatz Pampliega, Hongming Pan, Wei Pan, Theocharis Panaretaki, Aseem Pandey, Areti Pantazopoulou, Zuzana Papackova, Daniela L Papademetrio, Issidora Papassideri, Alessio Papini, Nirmala Parajuli, Julian Pardo, Vrajesh V Parekh, Giancarlo Parenti, Jong-In Park, Junsoo Park, Ohkmae K Park, Roy Parker, Rosanna Parlato, Jan B Pary, Katherine R Parzych, Jean-Max Pasquet, Benoit Pasquier, Kishore BS Pasumarthi, Daniel Patschan, Cam Patterson, Sophie Pattingre, Scott Pattison, Arnim Pause, Hermann Pavenstädt, Flaminia Pavone, Zully Pedrozo, Fernando J Peña, Miguel A Peñalva, Mario Pende, Jianxin Peng, Fabio Penna, Josef M Penninger, Anna Pensalfini, Salvatore Pepe, Gustavo JS Pereira, Paulo C Pereira, Verónica Pérez-de la Cruz, María Esther Pérez-Pérez, Diego Pérez-Rodríguez, Dolores Pérez-Sala, Celine Perier, Andras Perl, David H Perlmutter, Ida Perrotta, Shazib Pervaiz, Maija Pesonen, Jeffrey E Pessin, Godefridus J Peter, Morten Petersen, Irina Petrache, Basil J Petrof, Goran Petrovski, James M Phang, Mauro Piacentini, Marina Pierdominici, Philippe Pierre, Valérie Pierrefite-Carle, Federico Pietrocola, Felipe X Pimentel-Muiño, Mario Pinar, Benjamin Pineda, Ronit Pinkas-Kramarski, Marcello Pinti, Paolo Pinton, Bilal Piperdi, James M Piret, Leonidas C Platania, Harald W Platta, Edward D Plowey, Stefanie Pöggeler, Marc Poirot, Peter Polčic, Angelo Poletti, Audrey H Poon, Hana Popelka, Blagovesta Popova, Izabela Poprawa, Shibu M Poulose, Joanna Poulton, Scott K Power, Ted Power, Mercedes Pozuelo- Rubio, Krisna Prak, Reinhild Prange, Mark Prescott, Muriel Priault, Sharon Prince, Richard L Proia, Tassula Proikas-Cezanne, Holger Prokisch, Vasilis J Prompona, Karin Przyklenk, Rosa Puertollano, Subbiah Pugazhenthi, Luigi Puglielli, Aurora Pujol, Julien Puyal, Dohun Pyeon, Xin Qi, Wen-bin Qian, Zheng-Hong Qin, Yu Qiu, Ziwei Qu, Joe Quadrilatero, Frederick Quinn, Nina Raben, Hannah Rabinowich, Flavia Radogna, Michael J Ragusa, Mohamed Rahmani, Komal Raina, Sasanka Ramanadham, Rajagopal Ramesh, Abdelhaq Rami, Sarron Randall- Demllo, Felix Randow, Hai Rao, V Ashutosh Rao, Blake B Rasmussen, Tobias M Rasse, Edward A Ratovitski, Pierre-Emmanuel Rautou, Swapan K Ray, Babak Razani, Bruce H Reed, Fulvio Reggiori, Markus Rehm, Andreas S Reichert, Theo Rein, David J Reiner, Eric Reit, Jun Ren, Xingcong Ren, Maurizio Renna, Jane EB Reusch, Jose L Revuelta, Leticia Reye, Alireza R Rezaie, Robert I Richard, Des R Richardson, Clémence Richetta, Michael A Riehle, Bertrand H Rihn, Yasuko Rikihisa, Brigit E Riley, Gerald Rimbach, Maria Rita Rippo, Konstantinos Riti, Federica Rizzi, Elizete Rizzo, Peter J Roach, Jeffrey Robbin, Michel Roberge, Gabriela Roca, Maria Carmela Roccheri, Sonia Rocha, Cecilia MP Rodrigue, Clara I Rodríguez, Santiago Rodriguez de Cordoba, Natalia Rodriguez-Muela, Jeroen Roelof, Vladimir V Rogov, Troy T Rohn, Bärbel Rohrer, Davide Romanelli, Luigina Romani, Patricia Silvia Romano, M Isabel G Roncero, Jose Luis Rosa, Alicia Rosello, Kirill V Rosen, Philip Rosenstiel, Magdalena Rost-Roszkowska, Kevin A Roth, Gael Roué, Mustapha Roui, Kasper M Rouschop, Daniel T Ruan, Diego Ruano, David C Rubinsztein, Edmund B Rucker III, Assaf Rudich, Emil Rudolf, Ruediger Rudolf, Markus A Ruegg, Carmen Ruiz-Roldan, Avnika Ashok Ruparelia, Paola Rusmini, David W Ru, Gian Luigi Russo, Giuseppe Russo, Rossella Russo, Tor Erik Rusten, Victoria Ryabovol, Kevin M Ryan, Stefan W Ryter, David M Sabatini, Michael Sacher, Carsten Sachse, Michael N Sack, Junichi Sadoshima, Paul Saftig, Ronit Sagi-Eisenberg, Sumit Sahni, Pothana Saikumar, Tsunenori Saito, Tatsuya Saitoh, Koichi Sakakura, Machiko Sakoh-Nakatogawa, Yasuhito Sakuraba, María Salazar-Roa, Paolo Salomoni, Ashok K Saluja, Paul M Salvaterra, Rosa Salvioli, Afshin Samali, Anthony MJ Sanchez, José A Sánchez-Alcázar, Ricardo Sanchez-Prieto, Marco Sandri, Miguel A 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Subjects
[SDV]Life Sciences [q-bio], autophagosome, Review Article, ddc:616.07, stress, stre, LC3, MESH: Animals, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, Settore BIO/06 - Anatomia Comparata E Citologia, chaperone-mediated autophagy, ComputingMilieux_MISCELLANEOUS, Settore BIO/11, Pharmacology. Therapy, Settore BIO/13, standards [Biological Assay], autolysosome, MESH: Autophagy*/physiology, lysosome, methods [Biological Assay], Biological Assay, Settore BIO/17 - ISTOLOGIA, Erratum, Human, Biochemistry & Molecular Biology, Settore BIO/06, physiology [Autophagy], Chaperonemediated autophagy, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, NO, autophagy, guidelines, molecular biology, ultrastructure, flux, macroautophagy, phagophore, vacuole, MESH: Biological Assay/methods, MESH: Computer Simulation, ddc:570, Autolysosome, Autophagosome, Chaperonemediated autophagy, Flux, LC3, Lysosome, Macroautophagy, Phagophore, Stress, Vacuole, Autophagy, Animals, Humans, Computer Simulation, Settore BIO/10, ddc:612, Biology, MESH: Humans, Animal, 0601 Biochemistry And Cell Biology, MESH: Biological Assay/standards, Human medicine
Abstract

Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes.For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure flux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy.Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation, it is imperative to target by gene knockout or RNA interference more than one autophagy-related protein. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways implying that not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular assays, we hope to encourage technical innovation in the field.

Published
2016

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