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Abstract The COVID-19 pandemic has caused significant mortality and morbidity for millions of people. Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) virus is capable of causing severe and fatal diseases. We evaluated the antiviral properties of Aspergillus tamarii SP73-EGY isolate extract against low pathogenic coronavirus (229E), Adeno-7- and Herpes-2 viruses. The extract showed a high selectivity index (SI = 43.4) and a significant inhibition of 229E (IC50 = 8.205 μg/ml). It was stronger than the drug control, remdesivir (IC50 = 38.2 μg/ml, SI = 7.29). However, the extract showed minimal efficacy against Adeno-7- and Herpes-2-Viruses (IC50 = 22.52, 47.79 μg/ml, and SI = 6.75, 5.08, respectively). It exhibited profound efficacy against the highly pathogenic SARS-CoV-2 (IC50 = 8.306 μg/ml, SI = 42.2). Kojic acid, the primary component of the extract, showed substantial antiviral activity against SARS-CoV-2 (IC50 = 23.4 μg/ml, SI = 5.6), Remdesivir (IC50 = 4.55 μg/ml, SI = 61.45). Therefore, the extract demonstrated the most notable antiviral characteristics against coronavirus infection. Co-infecting microorganisms may contribute to immune system deterioration and airway injury caused by SARS-CoV-2. The extract showed significant efficacy against E. coli and P. aeruginosa , with an inhibition range of 3.5–10 mm at a concentration of 200 mg/ml. A molecular docking study showed that hexadecanoic, Kojic, octanoic acids, and 4(4-Methylbenzylidene)cyclohexane-1,3-dione have stronger binding affinity to the SARS-CoV-2 Mpro than Remdesivir. Molecular dynamics simulations were employed to examine the structural stability and flexibility of these complexes. This confirmed the high binding affinities of Kojic acid and 4(4-Methylbenzylidene)cyclohexane-1,3-dione, thereby proving their potential as novel anti-SARS-CoV-2.

Abstract Background Maternal diabetes during pregnancy may alter the metabolomic profile of the offspring, increasing the risk of perinatal complications and potentially predisposing them to adverse metabolic consequences during later life. To assess this risk, we aimed to study the levels of amino acids and acylcarnitines in the cord blood of infants of diabetic mothers (IDMs). Methods Fifty term-IDMs were compared to 25 healthy newborns. Of the diabetic mothers, 37 had gestational diabetes mellitus (GDM), and 13 had pre-gestational diabetes mellitus (PGDM). Amino acid and acylcarnitine concentrations were measured in dried spot samples of cord blood using ultra-performance liquid chromatography–mass spectrometry (UPLC-MS). Results We observed significantly higher levels of valine, aspartic acid, the leucine-to-isoleucine (Leu:Ile), and leucine-to-phenylalanine (Leu:Phe), and decreased values of methionine and the phenylalanine-to-tyrosine (Phe:Tyr) in neonates in the GDM group compared to controls. Neonates of mothers with GDM showed higher levels of C2-carnitine, C5-carnitine, C5:1, and C4-OH (C3-DC) compared to controls. Neonates of mothers with PGDM also showed higher levels of C2-carnitine, C0-carnitine, and C5:1 compared to controls. There were no significant differences in amino acids or acylcarnitine levels between IDMs with GDMs and PGDMs. Principle component analysis (PCA) showed that principal component 1 (PC1) was responsible for the majority of differences between IDMs and controls. PC1 consisted of aspartic, valine, leu:lle, C4-OH(C3-DC), C2-carnitine, C0-carinitine, C5-carnitine, C18:1, and C16:1. Variable importance in projection (VIP) scores based on PLS-DA loadings showed high values for aspartic, valine, leu:lle, Leu:Phe, C4-OH(C3-DC), C2-carnitine, C0-carnitine, C5:1, C5-DC, C18:1, C16:1, C5-carnitine in IDMs, and high values for Met:Phe, methionine, and Phe:Tyr in controls. Conclusion Maternal diabetes leads to alterations in amino acid concentrations and the carnitine shuttle pathway of their offspring.

Abstract Background Premature rupture of the membrane (PROM), refers to rupture of the fetal membranes prior to the onset of regular uterine contractions. When this occurs at term (≥ 37 weeks of gestation), it is classified as PROM, whereas if it occurs before 37 weeks, it is termed preterm premature rupture of membranes (PPROM). PROM and PPROM are linked to adverse outcomes for both mother and newborn. Objectives To investigate the factors associated with PROM and the outcomes of pregnancies complicated with PROM. Methods This was a retrospective cohort study. The participants were divided into three groups; those with PROM, those with PPROM and a control group who had normal onset of membranes rupture. The groups were compared with respect to predictors of PROM (maternal demographic profile, obstetrical history, and comorbidities), in addition to outcomes (postpartum hemorrhage, hospital stay, low APGAR scores, sepsis, low birthweight, preterm rate, and admission to neonatal Intensive care Unit (NICU)). Multivariable logistic regression model was used for predicting risk factors associated with PROM and PPROM. Results A total of 1,894 pregnant women were enrolled in the study, 77.6% had normal onset of ruptured membranes, while 382 (20.1%) were diagnosed with a PROM and 43 (2.3%) diagnosed with PPROM. Primiparous mothers were more likely to develop PROM (AOR = 1.56, 95% CI (1.10–2.22)) as compared to multiparous, while obese and overweight mothers were less likely to develop PPROM (AOR = 0.86, 95% CI (0.94 − 0.49)). Significantly more mothers with PPROM were delivered by emergency cesarean Sect. (30.2% vs. 22.9%, P

Background/aim Ellagic acid (EA) is widely recognized as a natural compound with pharmacological potency as a polyphenolic molecule, possessing antioxidant, anti-inflammatory, antimutagenic, and antiproliferative characteristics. The present study aims to evaluate the potential neuroprotective effect of EA in retinal degeneration induced experimentally in rabbits. Material and methods A total of 27 male white New Zealand rabbits, with an average weight ranging from 1.5 to 2 kg, were divided into three groups (nine each). Group I served as the control group, while group II and group III, the macular degeneration (MD) induction groups that received a single intravitreal injection of sodium iodate (SI). Following the injection, group III was given 50 mg/kg of EA powder for 21 days, starting immediately after MD induction. Ophthalmic examinations of the retinas were conducted on days 7, 14, and 21 using a fundus camera, followed by electroretinogram (ERG) recording after MD induction. Apoptotic caspase-3 and caspase-7 activities in the retina tissues were also measured postdecapitation. Results The results showed a significant decrease (P≤0.05) in electroretinogram ‘a- and b-waves’ following intravitreal SI injection in group II and III comparing with control group. The pattern of internucleosomal fragmentation, indicating apoptosis, was time-dependent. The injection also increased relative caspase-3 and caspase-7 activity. However, group III of rabbits that is treated with EA exhibited noticeable improvements in these outcomes in comparing with group of MD-induced rabbits. Conclusions The administration of EA demonstrated a notable impact in improving the retina’s function, and decreased the apoptosis levels in MD model of rabbits

Abstract Inflammation serves as an intricate defense mechanism for tissue repair. However, overactivation of TLR4-mediated inflammation by lipopolysaccharide (LPS) can lead to detrimental outcomes such as sepsis, acute lung injury, and chronic inflammation, often associated with cancer and autoimmune diseases. This study delves into the anti-inflammatory properties of “Aspergillus unguis isolate SP51-EGY” on LPS-stimulated RAW 264.7 macrophages. Through real-time qPCR, we assessed the expression levels of pivotal inflammatory genes, including iNOS, COX-2, TNF-α, and IL-6. Remarkably, our fungal extracts significantly diminished NO production and showed noteworthy reductions in the mRNA expression levels of the aforementioned genes. Furthermore, while Nrf2 is typically associated with modulating inflammatory responses, our findings indicate that the anti-inflammatory effects of our extracts are not Nrf2-dependent. Moreover, the chemical diversity of the potent extract (B Sh F) was elucidated using Q-TOF LC-HRMS, identifying 54 compounds, some of which played vital roles in suppressing inflammation. Most notably, compounds like granisetron, fenofibrate, and umbelliprenin were found to downregulate TNF-α, IL-1β, and IL-6 through the NF-κB signaling pathway. In conclusion, “Aspergillus unguis isolate SP51-EGY”, isolated from the Red Sea, Egypt, has been unveiled as a promising TLR4 inhibitor with significant anti-inflammatory potentials, presenting novel insights for their potential therapeutic use in inflammation.

Abstract Background Since many newly diagnosed breast cancer patients have breast MRI, the value of preoperative breast magnetic resonance imaging would improve if molecular subtypes could be consistently identified, and prognostic information provided in addition to diagnostic imaging. Breast edema may improve the ability to predict molecular subtypes and clinical and pathological outcomes in invasive breast cancer patients. The prognosis for breast cancer prognosis based on the findings of breast edema by magnetic resonance imaging will be useful in both pretreatment planning and prognosis. Breast edema on T2-weighted images and STIR was scored on a scale of 1 to 4, as follows: (a) breast edema score (BES) 1, no edema; (b) BES 2, peritumoral edema; (c) BES 3, pre pectoral edema; and (d) BES 4, subcutaneous edema (suspicious for occult inflammatory breast cancer “IBC”). Axillary lymph node status and number were also evaluated in T2 and STIR and after contrast administration. The aim of this work was to assess the role of tumour-related breast edema MRI features in distinguishing molecular subtypes of breast cancer and its effect on pathological axillary lymph nodes in patients with breast cancer. Results There was a highly significant difference between BES with respect to the molecular subtypes of breast cancer, size of the mass, Ki-67 expression, LN status, and LN number (p

Background: Chronic Myelomonocytic Leukemia (CMML) is a rare and aggressive form of leukemia with characteristics of both myeloproliferative neoplasms (MPNs) and myelodysplastic syndromes (MDSs). This study aims to explore the clinical features, survival outcomes, and prognostic factors in CMML patients over the past 20 years using a large sample. Methods: The study data from 4124 patients diagnosed with CMML between 2000 and 2017 were sourced from the SEER database. Demographic and clinical characteristics, along with overall and cancer-specific mortality, were examined. Factors with a p-value < 0.01 in univariate Cox regression were included in the multivariate Cox model to identify independent prognostic factors, with hazard ratios (HRs) greater than one indicating adverse outcomes. Results: The majority of the cohort were male (61.57%), and most diagnoses occurred between ages 60–79 (55.16%), with a small percentage under 40 (1.41%). Non-Hispanic whites represented the largest racial group (79.03%). Multivariate analysis showed higher mortality in males, those aged 80+, residents in metropolitan areas with populations between 250,000 and 1 million, single or widowed individuals, and those who underwent chemotherapy. Conversely, lower mortality was associated with an annual income of $75,000+. Conclusions: CMML remains a rare and highly aggressive hematologic disorder. This U.S.-based retrospective cohort study identified male gender, advanced age, single or widowed status, and chemotherapy as independent poor prognostic factors. While it is expected that older patients and those requiring chemotherapy would have a poorer prognosis, the higher mortality risk in single or widowed patients, as well as males, warrants further investigation. The early involvement of family and community support may help reduce mortality in these groups, suggesting a need for larger prospective studies to explore these associations further.

Background and aim: Malnutrition is one of the most troublesome comorbidities among hemodialysis patients (HD). Myostatin (MSTN) belongs to the transforming growth factor-β superfamily. In HD patients, MSTN effects are not limited to skeletal muscle growth. The present study aimed to assess MSTN levels in HD patients and its relation to various clinical and biochemical parameters. Patients and methods: The present case control study included 60 patients on HD for at least three years. In addition, there were age and sex-matched healthy subjects who constitutes the control group. Nutritional status was evaluated using the malnutrition inflammation score (MIS). Muscle wasting in the present study was evaluated using the lean tissue index (LTI) as assessed by the body composition monitor (BCM). Rectus Femoris Muscle (RFM) thickness was also measured as indicator for nutritional status of patient. Results: The present study included 60 HD patients, and ageand sex-matched healthy controls. Patients expressed significantly higher myostatin levels when compared to controls [median (IQR): 221.3 (153.5-688.2) versus 144.8 (97.0-281.7), p < 0.001]. According to MIS, patients were classified into those with no/mild malnutrition (n = 22) and others with moderate/severe malnutrition (n = 38). Comparison between the two subgroups revealed that the former group had significantly lower myostatin levels [167.7 (150.3-236.3) versus 341.7 (160.9-955.9), p = 0.004]. According to LTI, patients were classified into those with muscle wasting (n = 23) and others without muscle wasting (n = 37). Comparative analysis showed that patients in the former group had significantly higher myostatin levels [775.1 (325.1-2133.7) versus 161.8 (142.6-302.3), p < 0.001]. Conclusions: Myostatin seems to be a promising marker for identification of malnutrition and muscle wasting in HD patients.

Objective: To point out our experience and assess the efficacy and safety of real-time ultrasound-guided central internal jugular vein (IJV) catheterization in the treatment of hemodialysis patients. Methods: This retrospective study comprised 150 patients with end-stage renal disease (ESRD) who had real-time ultrasonography (US)-guided IJV HD catheters placed in our hospital between March 2019 and March 2021. Patients were examined for their demographic data, etiology, site of catheter insertion, type (acute or chronic) of renal failure, technical success, operative time, number of needle punctures, and procedure-related complications. Patients who have had multiple catheter insertions, prior catheterization challenges, poor compliance, obesity, bony deformity, and coagulation disorders were considered at high-operative risk. Results: All patients experienced technical success. In terms of patient clinical features, an insignificant difference was observed between the normal and high-risk groups (p-value > 0.05). Of the 150 catheters, 62 (41.3%) were placed in high-risk patients. The first-attempt success rate was 89.8% for the normal group and 72.5% for the high-risk group (p = 0.006). IJV cannulation took less time in the normal-risk group compared to the highrisk group (21.2 ± 0.09) minutes vs (35.4 ± 0.11) minutes, (p < 0.001). There were no serious complications. During the placing of the catheter in the internal jugular vein, four patients (6.4%) experienced arterial puncture in the high-risk group. Two participants in each group got a small neck hematoma. One patient developed a pneumothorax in the high-risk group, which was managed with an intercostal chest tube insertion. Conclusions: Even in the high-risk group, the real-time US-guided placement of a central catheter into the IJV is associated with a low complication rate and a high success rate. Even under US guidance, experience lowers complication rates. Real-time USguided is recommended to be used routinely during central venous catheter insertion.

Purpose: For patients with a failed forearm autogenous fistula (AF) and an exhausted cephalic vein, there is controversy about whether a brachial basilic AF with transposition or an arteriovenous prosthetic bridging graft (BG) must be the second vascular access option. This work measured and compared these two modalities according to patency rates, complications, and revisions. Patients and methods: A retrospective study of 104 cases that had either a brachial basilic AF (72) or an Arteriovenous BG (32). Technical success, operative complications, procedurerelated mortality, maturation time, functional primary, secondary, and overall patency rates were all assessed. Results: Technical success was obtained in all participants. No procedure-linked mortality. Maturation time for BGs was significantly shorter than AFs. The complication rate was significantly higher in BGs than in AFs. The most prevalent complication was access thrombosis. The functional primary patency rate was significantly higher in AF than in BG at 12-month followup: 77.7% vs 53.1% (p < 0.012). secondary patency rate was higher in AF than in BG at 1-year follow-up 62.5% vs 42.8% (p = 0.063), respectively. In addition, BGs required more interventions to preserve patency. Conclusions: AF had higher primary, secondary and overall functional patency rates and needed fewer procedures to keep patency than BGs. Cases that need early vascular access as a result of central venous catheter complications or who have a reduced life expectancy may benefit from BGs.

هدف هذا البحث إلى تحليل الاحتياج التدريبي للجدارات التقنية المعرفية النظرية والتطبيقية العملية وتلك المرتبطة بالسلامة والصحة المهنية للمدربين والمتدربين، والتواصل الفعال مع ذوي الاعاقة في الوسط المائي قبل وبعد واثناء فترة التدريب، وتقييم درجة امتلاكهم للجدارات المهنية التي تم التوصل اليها واقتراحها في هذا البحث وتحليل حاجتهم للتدرب عليها. اختار الباحثون المنهج الوصفي التحليلي كطريقة لإجراء البحث ،والاستبانة التي تم تقنينها من قبل خبراء كأداة لجمع البيانات، بجانب تقنين الجدارات المقترحة بتمريرها على الخبراء وتجريبها على عينة تجريبية، ثم تمريرها لعينة البحث الأساسية، وتكونت عينة البحث الاساسية والتجريبية من خبراء ومتخصصين ومدربين ومدربات بلغ عددهم (84) فرداً، ثم لخص الباحثون، أهم نتائج البحث على أساس أسئلة وأهداف البحث وقد اتفقت عينة البحث على الحاجة للتدريب على جدارة تحقيق السلامة والصحة للمدربين والمتدربين 98% بدرجة كبيرة جدا تليها جدارة التمرينات العلاجية في الماء باستخدام أجهزة وأدوات مساعدة 97% ثم جدارة اسس تصميم البرامج العلاجية بالتركيز على درجة الاصابة الطرفية 95%،فجدارة إجراء الاختبارات التشخيصية ،والتمرينات العلاجية في الماء 93%، وقد اوصى الباحثون باعتماد قائمة الجدارات التي تم التوصل اليها في هذا البحث كدليل للتدريب المهني للعاملين من التقنين الكوادر الطبية المساعدة وخريجي كليات التربية البدنية والرياضة بجانب تناولها بالتطوير للمواكبة دورياً.

Background: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.Aim of the work: This study aimed to evaluate the effect of Silymarin/Curcumin in ameliorating the hepatotoxic effect induced in albino rats following oral administration of BPA.Patients and Methods: Fourty adult male albino rats were included and randomly categorized into four equal groups. The control group and BPA-exposed [50 mg/kg] group. Groups 3 and 4 for rats received oral BPA [50 mg/kg] plus [100 mg/ kg] of curcumin or silymarin. Serum liver enzymes, pro-inflammatory cytokines [TNF-α & IL-1,6,8] and the oxidant/antioxidant profile were assessed in the serum. SOD, GPX and CAT levels, MDA and H2O2 were assessed. Histopathological changes of the liver, immunohistochemical detection of caspase 3 and area density of collagen fibres were also assessed.Results: Bisphenol-A administration for 30 days was associated with a significant increase in the number of pro-inflammatory markers as interleukin 1,6,8 and tumor necrosis factor‑α [TNF-α]. It also, stimulates oxidative stress with structural changes, apoptosis and fibrosis in hepatic cells. Treatment with curcumin or silymarin for 30 days lead to a reduction of pro‑inflammatory mediators and significant amelioration of structural changes.Conclusion: Silymarin/Curcumin had an ameliorative of harmful effects of BPA on the liver cells through potent anti-inflammatory, antiapoptotic and antioxidant effects.

Abstract Hepatitis B virus (HBV) infection is a significant health issue worldwide.. We attempted to fulfill the molecular mechanisms of epigenetic and genetic factors associated with chronic HBV (CHBV). Expression levels of the lncRNA growth arrest-specific 5 (GAS5) and miR-137 and their corresponding SNPs, rs2067079 (C/T) and rs1625579 (G/T) were analyzed in 117 CHBV patients and 120 controls to investigate the probable association between these biomarkers and CHBV pathogenesis in the Egyptian population. Serum expression levels of GAS5 and miR-137 were significantly down-regulated in cases vs controls. Regarding GAS5 (rs2067079), the mutant TT genotype showed an increased risk of CHBV (p

Background/aim:IFNG-AS1 is a long noncoding RNA that works as an enhancer for the Interferon-gamma (IFN-γ) transcript. GAS5 (growth arrest-specific 5) is a lncRNA that is associated with glucocorticoid resistance. Aberrant expressions of IFNG-AS1 and GAS5 are directly linked to numerous autoimmune disorders but their levels in childhood ITP are still obscure. This study aims to elucidate expressions of target lncRNAs in childhood ITP and their association with pathophysiology and clinical features of the disease as well as their association with types and treatment responses.Method: The fold changes of target lncRNAs in blood samples from children with ITP and healthy controls were analyzed using quantitative real-time PCR (qRT-PCR).Results: There were overexpressed lncRNAs IFNG-AS1 and GAS5 in serum of childhood ITP patients [(median (IQR) = 3.08 (0.2–22.39) and 4.19 (0.9–16.91) respectively, Also, significant higher IFNG-AS1 and GAS5 (p < 0.05) were present in persistent ITP (3–12 months) [ median (IQR) = 4.58 (0.31–22.39) and 3.77 (0.87–12.36) respectively] or chronic ITP (>12 months) [ median (IQR) = 5.6 (0.25–12.59) and 5.61 (1.15–16.91) respectively] when compared to newly diagnosed

Abstract Background To identify and report flaws of Internet-published articles in the Journal of the Egyptian National Cancer Institute (JENCI), Cairo University, through a retrospective documentary study on articles published during the period from 2011 to 2016. All sections were reviewed against a collective checklist. Articles were grouped by publication year into 2 intervals: early (from 2011 to 2013) and recent (from 2014 to 2016) to identify changes in study characteristics over time. Results The study included 139 original articles. Half of the titles represented aim and 9.4% represented study design. Abstracts were concise, clear, with structured writing format in 98.6%, 93.5%, and 35.3%, respectively. Most introductions included the study aim, while 41% had a rationale. Study timing was reported in 59.0%, while the study design was reported in 25.9%. Inclusion and exclusion criteria were clearly reported in 43.1% and 40.1%, respectively. Statistical methods were mentioned in 80.6%, complete in 30.4%, and appropriate in 85.7%. Four studies reported sample size estimation. Only 52.5% and 58.3% of results were exhaustive and answer the research question, respectively. Incorrect statistical calculations occurred in 41.0%, inappropriate statistical tests or descriptive parameter selection in 26.6%, while inappropriate test application occurred in 49.1%. About 60% of discussions did not completely cover results, 31.7% fully justified the findings, 56.1% followed a logical flow, and 36.7% had contradiction within the text. Conclusions were mostly linked to aim, imprecise, and extrapolating beyond results. On comparing both periods, only a significant less misuse of statistical terms, more reporting conflict of interest, more missing references for cited texts in the recent period, and more participation of NCI over other institutes in the early period were found. Conclusion Articles published in JENCI (from 2011 to 2016) had many methodological and reporting defects and some points of strength. Using the collective checklist developed by this study, continuous training of researchers, involving epidemiologists throughout the whole research process, and applying strict journal reporting and publication rules should be encouraged.

Magic squares is n×n matrix with positive integer entries as well as the sum of rows, columns and mains diagonal have the same magic constant, one of the most oldest magic square was discovered in china. In this paper the history of magic square is displayed and some definition of its kind is given the prove of two theorems about properties of magic square is introduced.

Abstract Objectives The current study revealed that the used stabilizers greatly affect the morphology as well as the aspect ratio of the obtained gold nanoparticles. Background Control of the morphology and dimensions of gold nanoparticles during the preparation is an important task for targeting certain applications in demand. Material and methods Gold nanoparticles were prepared by the reduction of tetrachloroauric(III) acid in the presence of different stabilizers: polyethyleneimine (PEI), polyvinylpyrrolidone (PVP), and chitosan. Results In the case of using polyethyleneimine, the produced nanoparticles showed a homogenous spherical structure. Meanwhile, in the case of using polyvinylpyrrolidone and chitosan, the produced nanoparticles experience non-homogenous morphology with great diversity. Transmission electron microscopy (TEM) and UV-visible spectrophotometry (UV-vis) techniques were employed to study the criteria of the obtained gold nanoparticles. Conclusions It was obviously concluded that the type and concentration of the reducing agents that were added during gold preparation and acted as stabilizer templates affect to a great extent the morphology and particle shape. Also, stabilizers affect the homogeneity of the produced gold nanoparticles. In the case of using polyethyleneimine, the produced nanoparticles showed a homogenous spherical structure. Meanwhile, in the case of polyvinylpyrrolidone and chitosan, the produced nanoparticles experience non-homogenous morphology with great diversity.

BackgroundThe decrease in the number of adolescents showing genuine interest in the fields of healthcare has been one of the recent concerns worldwide. A plethora of studies have discussed the factors that influence career choices of high school students, including science educational pedagogies, gender, environment, the student’s cognitive capabilities, and social perceptions of occupations being gender-based. As reported in 2012, a majority of the Qatari high-school students have shown a greater interest in business, technological, and administrative careers and a lower interest in healthcare. Comprehensive national and institutional strategies have since been utilized to direct the interest of Qatari generation toward healthcare careers.ObjectiveThe primary objective of this case-control study is to assess the effect of schooling type on the enrollment in the Empower Generations (EG) career training in healthcare at the Qatar University. The secondary objectives are: (1) to describe the effect of initial career interest on the EG and healthcare majors composite’s enrollments and (2) assess the association between the history of enrollment in EG and university GPAs.MethodThis is a case-control study that utilized the Qatar University’s enrollment databases for the health professions majors, that is, Health Sciences, Medicine, Pharmacy, and Dentistry. The datasets were collected from the registration records between 2013 and 2020. The statistical analysis was performed on the Statistical Package for the Social Sciences (SPSS) software version 26; the study used Chi-Square Test and Independence and logistic regression to assess the effect of schooling type and initial career interest on the enrollment in the EG training at the Qatar University. All statistics were tested for p = 0.05 and 95% CI.ResultsTotal QU-Health records of admissions from 2013 to 2020 involve 562 eligible students. A total of 180 students (32%) attended EG training before they were admitted to QU-Health, whereas a total of 382 (68%) were enrolled to QU-Health without attending EG training. The study revealed significant findings regarding the association between EG training and international schools (p < 0.001). Among the group who attended EG training, there were 63 students (75%) who reported that they did not have an initial career interest before they joined the EG training compared to 21 students (25%) reported that they did not have an initial career interest but enrolled immediately to healthcare majors. The findings indicate insignificant association between the history of EG training and the high school percentage p = 0.397. However, the association between a history of EG training and the university’s GPA is significant, with a p < 0.001, OR 5.016 (2.954–8.518).ConclusionThe study has shown significant association between the EG training enrollment and the type of school and the initial career interest of high school students. The EG training is perceived to direct the interest of high school students toward the careers of healthcare and is thought to enhance the performance of college students through their university’s GPAs.

Abstract Background As the copper ferrite gains more attention due to its unique electronic, thermal, and catalytic properties, the need to explore the mechanism of its formation is becoming a task to be studied. Results The mechanism of copper ferrite formation was studied by in situ XRD, and IR results showed comparison that the formation of Fe3O4 was formed by in situ heating. Conclusions These results shed light on the formation of ferrite first begun with the formation of Fe3O4, and then, incorporation of Cu2+ ion is done.

Abstract Background Green synthesis as a technique of preparation of metal/metal oxide nanomaterials is becoming an important and competitive method of preparation replacing the conventional method of preparation. Among metal oxides, nanocatalyst copper(II) oxide is considered as a very important and potent catalyst/photocatalyst with a very wide range of applications. Results In this work, copper(II) oxide nanoparticles were prepared with the assist of aqueous spinach extract from copper metal powder. Spinach extract catalyzes the formation of copper oxide nanoparticles with manipulation of chlorophyll that exists in the extract. The produced copper(II) oxide nanoparticles were characterized using scanning electron microscopy (SEM), energy dispersive X-ray (EDX), and X-ray diffraction (XRD). Conclusions It was proved that spinach extract catalyzes the preparation of copper(II) oxide nanocatalyst. It was elucidated from the characterization technique that the produced nanoparticles are pure copper oxide with particle size range of 60–100 nm.

Background Vaspin is a compensatory adipokine with anti-inflammatory properties that can improve insulin sensitivity and plays a cardioprotective role. Aim The aim of this study was to evaluate the level of vaspin in patients with end-stage renal disease on hemodialysis (HD) and to determine whether it has any relation to the presence of ischemic heart disease (IHD) in these patients. Patients and methods The study was carried out on 45 HD patients who were divided into 15 patients with risk factors of developing IHD (group I) and 30 patients (group II) proved to have IHD by echocardiography and ECG compared with 20 healthy individuals (group III). Results We found that the mean±SD of serum vaspin was significantly lower in HD patients with IHD (0.57±0.27) ng/ml compared with the control group (0.74±0.20) ng/ml and there was a negative correlation between serum vaspin and serum creatinine in group I and group II. Also, an receiver operating characteristics study for patients with IHD (group II) yielded a vaspin cut-off value of 0.410 ng/ml with a sensitivity of 40%, a specificity of 100%, a positive predictive value of 100%, and an negative predictive value of 53%, whereas the cut-off value for serum vaspin was 0.485 ng/ml in patients at risk of developing IHD, with a sensitivity of 100%, a specificity of 85%, a positive predictive value of 83%, and an negative predictive value of 100%. Conclusion Lower vaspin level is associated independently with IHD in HD patients and can be used as a predictor of IHD in patients with end-stage renal disease.

Probiotics can potentially prevent and treat diseases. We examined the inhibitory activity of bacteriocin-like inhibitory substances (BLISs) from potentially probiotic lactobacilli and streptococci on Candida albicans and non-Candida albicans clinical isolates from women with vulvovaginitis. Using agar well diffusion assays, BLISs inhibited both Candida albicans and non-Candida albicans isolates. The BLIS from L. pentosus isolates had the highest anti-Candida activity (33/45; 73.3%), followed by BLISs from isolates of L. paracasei subsp. paracasei (31/45; 68.9%), L. rhamnosus I (30/45; 66.7%), L. delbrueckii subsp. lactis I (30/45; 66.7%), and S. uberis II (30/45; 66.7%). Upon characterization according to the retained activity under variable physical and chemical conditions, the BLISs showed stability against heat, pH, and surfactants, but were protease-sensitive, which suggests a proteinaceous nature of the active substances. Using crystal violet assays, the BLISs reduced the Candida biofilm biomass significantly as compared to a control group that lacked BLISs. In vivo testing of the antagonistic activity was performed using the Galleria mellonella (G. mellonella) larvae model. BLISs significantly improved survival in G. mellonella larvae treated with Candida isolates on the first, second, and seventh days, as compared to larvae inoculated with Candida only (p < 0.01). The results show that BLISs can be used as biotherapeutic agents in vulvovaginal candidiasis.

The study of the Arabian Peninsula in terms of religion that preceded the emergence of Islam from the important studies that concern the history of the Arabs because of the relevance of the events that contributed in one way or another in the crystallization of the Arab social system later and formed one of the elements of the historical development of the Arabs. Their religious life is generally characterized by paganism, although it is a pagan of a special kind. It recognizes the existence of God, yet idols take a means to approach him. Paganism emerged alongside the pagan religious streams that played an active and important role in influencing the Arab mindset and preparing it to accept its historical role in embracing the last great divine messages. The research dealt with these monotheistic religious currents that were represented in Judaism, Christianity and Tafsia and discussed their existence and their impact on the Arab mentality in the Arabian Peninsula before Islam and was based on a number of mothers of primary sources and important references.

As the need to use green chemistry routes increases, environmentally friendly catalytic processes are a demand. One of the most important and abundant naturally occurring catalysts is chlorophyll. Chlorophyll is the first recognized catalyst; it is a reducing agent due to its electron-rich structure. The effects of spinach on the preparation of zinc oxide nanoparticles and the photocatalytic degradation of methyl orange and paraquat in sunlight and under a UV lamp and photocatalytic degradation in sunlight were studied. Different parameters of the catalytic preparation process and photocatalytic degradation process were studied. Characterization of differently prepared samples was carried out using different analytical techniques such as XRD, SEM, and EDX and finally the photocatalytic activity towards decomposition of methyl orange and paraquat.

Objective: Primary objective was to verify whether breast cancer patients aged less than 40 years at diagnosis have poorer prognosis than older patients. Secondary to assess prognostic factors influencing disease free survival. Methods: 941 women were diagnosed with non-metastatic breast cancer at NCI, Cairo in 2003. Epidemiologic, clinico-pathological characteristics, treatment modalities and disease free survival were compared among the two age groups. Prognostic factors were evaluated for association with disease-free survival. Results: One hundred-eighty-one patients (19.2%) were younger than 40 years and 760 (80.8%) were older. Older women presented with higher rates of comorbidities and younger women presented with more hormone non-responsive tumors. Young women presented with larger tumors pT4 = 13.8% compared to 8.6% in older women, yet not significant. Young women were treated with more conservative surgery, more adjuvant chemotherapy and radiotherapy while older women with more radical mastectomies and more hormonal treatment. Recurrence rates were significantly higher among young women 44.2% compared to 34.5% in older women. Five year disease free survival in young women was 38.9% ± 4.6% compared to 48.6% ± 2.5% with adjusted hazard ratio of 1.22 95% CI (0.91–1.64), p = 0.19. Multivariate analyses identified positive axillary lymph nodes (pN2-pN3), larger tumor size (pT3-pT4), hypertension, lobular carcinoma type and lack of adjuvant systemic treatment as independent factors associated with poor DFS. Conclusion: Young women were not found to have poorer prognosis, yet they presented with more ER negative tumors. Most of women presented with advanced stage and young women had higher recurrence rates.

A lot of educational institutions attention to children tried in many ways based on scientific studies Saiklogih, aimed at evaluating the child and his behavior and build character, to be an individual active role in the progress of society, in terms of the puppet theater is an integral part of the Children's Theatre, is an educational institution related directly affecting the child,therefore, it contributes in a manner effective in building character through the guidance and transmit the educational values ​​of ideas and links to social, cultural and moral, as well as recreation and entertainment as it provides proper behavior for a child about a lot of experience going through at the beginning of his life, contributed puppet theater in the formation of a group of structures, educationalthat have a positive impact in the construction of the child in all respects, and here the current defined research problem

The researcher studied at the current research character traits Hercules and representation in personalities text theatrical tragic Greek, where the combined search study the first to study the character traits of Hercules, including in respect of the basic features accompanied throughout his life and features a central appear in different positions as well as the attributes of secondary, and it was the second part had studied the book tragedy Greek, went researcher indicators framework for consideration of the character of Hercules stationed to represent Intellectual hub around which the events of legend where contributed actively in the growth of the events and their evolution, what was characterized by its richness in features and began appearing actual theater of Greek at the hands of Thespec who lived mid-sixth century before Birth was the first texts that come to us from Athens, where he grew up the dramatic form of songs exchange followed by talking between one representative and chorus as in plays of Aeschylus.