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Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media of different pH. Methods: Different formulations of slow-release matrix tablets of ciprofloxacin hydrochloride were prepared with polymers, namely, ethyl cellulose (Etc), hydroxyethyl cellulose (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using matrix embedding technique. The matrix tablets were characterized and studies of their dissolution profiles were studied in 0.1 N HCl (pH 1.2) and in simulated intestinal fluid (excluding enzymes) of pH 4.0, 6.0, and 7.4. Results: The tablets had the following characteristics: weight, 659.25 ± 7.96 to 661.65 ± 6.53 mg; hardness, 7.05 ± 0.21 to 9.60 ± 0.40 kgf; friability, 0.212 to 0.292 %; and drug content, 91.47 ± 0.53 to 112.50 ± 4.14 %. In batches prepared with ethyl cellulose, Eudragit L-100, and hydroxypropyl methylcellulose, drug release increased with a decrease in pH. However, matrix tablets prepared with hydroxyethyl cellulose displayed the highest drug release at pH 4.0 with Cmax of 108.75 % and T50% of 30.86 min; thereafter, drug release decreased with increase in pH. The pattern of drug release was Hec > Hpc > Eud > Etc in most media with more drug release in acidic than at alkaline pH. Conclusion: Release of ciprofloxacin from the formulated matrix tablets was pH-sensitive in vitro. This should be taken into consideration in designing sustained release oral form of ciprofloxacin.

This study was aimed at evaluating the effects of methanol extract of Imperata cylindrica and Jathropha curcas roots on testosterone-induced benign prostate hyperplasia (BPH) in male albino rats. A total of 27 male albino rats were divided into 9 Groups of 3 rats each. BPH was induced using 25 mg/kg b.w of testosterone propionate subcutaneously for 28 days in all the groups with exception of the normal control group, followed by treatment immediately, for 14 days. Biochemical assays such as liver function test (ALT, AST and ALP), kidney function test (Urea and Creatinine), antioxidant (SOD and CAT), MDA, testosterone, zinc concentration and prostate specific antigen (PSA) levels were analyzed using standard procedures. Prostate weight (prostate/body weight ratio) and percentage inhibition of prostate weights, were also calculated. The result obtained revealed a decrease in mean body weight from day 1 to day 14. The results showed a non-significant (p > 0.05) difference in the level of liver enzymes. The Malondialdehyde (MDA) concentrations significantly (p < 0.05) decreased was observed within the groups. A noticeable change was also observed in antioxidants enzymes. The prostate weight significantly decreased when decrease in prostatic index. These results suggest that methanol extract of Jathropha curcas roots and its combination with Imperata cylindrical may be effectively used in the management of BPH. Key words: Imperata cylindrical roots, Jathropha curcas roots, testosterone and benign prostate hyperplasia (BPH)