657 results on '"Alzari, Pedro M."'
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2. Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation
3. Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1
4. High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase
5. Actinobacteria challenge the paradigm : A unique protein architecture for a well-known, central metabolic complex
6. Gp29 LysA of mycobacteriophage TM4 can hydrolyze peptidoglycan through an N-acetyl-muramoyl-L-alanine amidase activity
7. Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response
8. Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress
9. 3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme
10. SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system
11. Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts
12. Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases
13. Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity
14. New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach
15. Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
16. Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to controlPlasmodiumSub1 subtilisin-like activity prior to prime merozoite egress
17. 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor
18. Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum
19. Plasmodium falciparum Subtilisin-Like Protease 2, a Merozoite Candidate for the Merozoite Surface Protein 1-42 Maturase
20. Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria
21. Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis
22. High resolution cryo-EM and crystallographic snapshots of the large actinobacterial 2-oxoglutarate dehydrogenase: an all-in-one fusion with unique properties
23. Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG
24. Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis
25. FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales
26. The Antibacterial Type VII Secretion System of Bacillus subtilis: Structure and Interactions of the Pseudokinase YukC/EssB
27. Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c
28. Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe–S center
29. The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase‐like conformation
30. Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
31. Mechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from Mycobacteria
32. Structural Plasticity and Catalysis Regulation of a Thermosensor Histidine Kinase
33. Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity
34. 3-Keto-5-aminohexanoate Cleavage Enzyme: A COMMON FOLD FOR AN UNCOMMON CLAISEN-TYPE CONDENSATION
35. Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket
36. Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism
37. Remodeling a DNA-Binding Protein as a Specific in vivo Inhibitor of Bacterial Secretin PulD
38. Crystal Structure, Catalytic Mechanism, and Mitogenic Properties of Trypanosoma Cruzi Proline Racemase
39. Molecular Basis of Phosphatidyl-myo-inositol Mannoside Biosynthesis and Regulation in Mycobacteria
40. Induction of Protective Immunity by Synthetic Vibrio cholerae Hexasaccharide Derived from V. cholerae O1 Ogawa Lipopolysaccharide Bound to a Protein Carrier
41. A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG
42. Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria: IMPLICATIONS FOR CATALYSIS
43. Functional in vitro assembly of the integral membrane bacterial thermosensor DesK
44. Three-Dimensional Structure of a Heteroclitic Antigen-Antibody Cross- Reaction Complex
45. Three-Dimensional Structure of Rat Liver 3α-Hydroxysteroid/ Dihydrodiol Dehydrogenase: A Member of the Aldo-Keto Reductase Superfamily
46. Resolution of Hypervariable Regions in T-Cell Receptor β Chains by a Modified Wu-Kabat Index of Amino Acid Diversity
47. Three-Dimensional Structure of Two Crystal Forms of FabR19.9 from a Monoclonal Anti-Arsonate Antibody
48. Mycobacterial Ser/Thr protein kinases and phosphatases: Physiological roles and therapeutic potential
49. Structural insights into sialic acid enzymology
50. Rising standards for tuberculosis drug development
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