1. Brains, genes, and primates
- Author
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Terrence J. Sejnowski, Shoukhrat Mitalipov, Afonso C. Silva, Patricia Smith Churchland, J. Anthony Movshon, Alysson R. Moutri, Kuo-Fen Lee, Dario L. Ringach, Cory T. Miller, John V. Reynolds, Peter L. Strick, Sarah J. Caddick, David A. Leopold, Gregg E. Homanics, Hideyuki Okano, Guoping Feng, Edward M. Callaway, Feng Zhang, Juan Carlos Izpisua Belmonte, Jude F. Mitchell, Jun Wu, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Feng, Guoping, and Zhang, Feng
- Subjects
Primates ,1.1 Normal biological development and functioning ,Neuroscience(all) ,Biology ,Genome ,Models, Biological ,Article ,Substance Misuse ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Models ,Underpinning research ,Genetics ,medicine ,Psychology ,Premovement neuronal activity ,Animals ,Humans ,Gene ,030304 developmental biology ,0303 health sciences ,Neurology & Neurosurgery ,Extramural ,General Neuroscience ,Neurosciences ,Brain ,Cognition ,Biological evolution ,Human brain ,Biological ,Biological Evolution ,Brain Disorders ,3. Good health ,Mental Health ,medicine.anatomical_structure ,Expression (architecture) ,Genes ,Neurological ,Cognitive Sciences ,Neuron ,Drug Abuse (NIDA only) ,Neuroscience ,030217 neurology & neurosurgery - Abstract
One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward., Poitras Center for Affective Disorders Research, Stanley Center for Psychiatric Research, Brain Research Foundation (Science Innovation Award)
- Published
- 2015