1. Multiphoton imaging of tumor biomarkers in situ using highly oriented conjugates of single-domain antibodies and quantum dots
- Author
-
Alyona Sukhanova, Hilal Hafian, Michel Pluot, Jacques H. M. Cohen, Jean-Marc Millot, Igor Nabiev, Alyona Sukhanava, Marc Turini, Patrick Chames, Daniel Baty, Laboratoire de Recherche en Nanosciences - EA 4682 (LRN), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Aix Marseille Université (AMU), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-SFR Condorcet, and Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
In situ ,Materials science ,medicine.diagnostic_test ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Nanotechnology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Conjugated system ,Immunofluorescence ,Fluorescence ,3. Good health ,Nuclear magnetic resonance ,Quantum dot ,medicine ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Single domain ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,Immunostaining ,Conjugate - Abstract
International audience; High-quality imaging for immunofluorescence diagnosis in medical practice requires a high sensitivity of labeling and discrimination between the fluorescence of immunostaining probes and tissue autofluorescence. Multiphoton microscopy with excitation in the near-infrared spectral region, far from the region of excitation of tissue autofluorescence, enables deep imaging of biological tissues. CdSe/ZnS quantum dots (QDs) conjugated to single-domain antibodies (sdAbs) are efficient diagnostic nanoprobes with diameters 40 times higher than that for one-photon excitation.
- Published
- 2015