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10. Maintenance Tyrosine Kinase Inhibitors Following Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia: A Center for International Blood and Marrow Transplant Research Study

Author

DeFilipp, Z, Ancheta, R, Liu, Y, Hu, Z-H, Gale, RP, Snyder, D, Schouten, HC, Kalaycio, M, Hildebrandt, GC, Ustun, C, Daly, A, Ganguly, S, Inamoto, Y, Litzow, M, Szer, J, Savoie, ML, Hossain, N, Kharfan-Dabaja, MA, Hamadani, M, Reshef, R, Bajel, A, Schultz, KR, Gadalla, S, Gerds, A, Liesveld, J, Juckett, MB, Kamble, R, Hashmi, S, Abdel-Azim, H, Solh, M, Bacher, U, Lazarus, H, Olsson, R, Cahn, J-Y, Grunwald, MR, Savani, BN, Yared, J, Rowe, JM, Cerny, J, Chaudhri, NA, Aljurf, M, Beitinjaneh, A, Seo, S, Nishihori, T, Hsu, JW, Ramanathan, M, Alyea, E, Popat, U, Sobecks, R, Saber, W, DeFilipp, Z, Ancheta, R, Liu, Y, Hu, Z-H, Gale, RP, Snyder, D, Schouten, HC, Kalaycio, M, Hildebrandt, GC, Ustun, C, Daly, A, Ganguly, S, Inamoto, Y, Litzow, M, Szer, J, Savoie, ML, Hossain, N, Kharfan-Dabaja, MA, Hamadani, M, Reshef, R, Bajel, A, Schultz, KR, Gadalla, S, Gerds, A, Liesveld, J, Juckett, MB, Kamble, R, Hashmi, S, Abdel-Azim, H, Solh, M, Bacher, U, Lazarus, H, Olsson, R, Cahn, J-Y, Grunwald, MR, Savani, BN, Yared, J, Rowe, JM, Cerny, J, Chaudhri, NA, Aljurf, M, Beitinjaneh, A, Seo, S, Nishihori, T, Hsu, JW, Ramanathan, M, Alyea, E, Popat, U, Sobecks, R, and Saber, W

Abstract

It remains unknown whether the administration of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 after allogeneic hematopoietic cell transplantation (HCT) is associated with improved outcomes for patients with chronic myelogenous leukemia (CML). In this registry study, we analyzed clinical outcomes of 390 adult patients with CML who underwent transplantation between 2007 and 2014 and received maintenance TKI following HCT (n = 89) compared with no TKI maintenance (n = 301), as reported to the Center for International Blood and Marrow Transplant Research. All patients received TKI therapy before HCT. The majority of patients had a disease status of first chronic phase at HCT (n = 240; 62%). The study was conducted as a landmark analysis, excluding patients who died, relapsed, had chronic graft-versus-host disease, or were censored before day +100 following HCT. Of the 89 patients who received TKI maintenance, 77 (87%) received a single TKI and the other 12 (13%) received multiple sequential TKIs. The most common TKIs used for maintenance were dasatinib (n = 50), imatinib (n = 27), and nilotinib (n = 27). As measured from day +100, the adjusted estimates for 5-year relapse (maintenance, 35% versus no maintenance, 26%; P = .11), leukemia-free survival (maintenance, 42% versus no maintenance, 44%; P = .65), or overall survival (maintenance, 61% versus no maintenance, 57%; P = .61) did not differ significantly between patients receiving TKI maintenance or no maintenance. These results remained unchanged in multivariate analysis and were not modified by disease status before transplantation. In conclusion, our data from this day +100 landmark analysis do not demonstrate a significant impact of maintenance TKI therapy on clinical outcomes. The optimal approach to TKI administration in the post-transplantation setting in patients with CML remains undetermined.

Published
2020

16. Study of single muons with the Large Volume Detector at the Gran Sasso Laboratory

Author

Aglietta, M., Alyea, E. D., Antonioli, P., Badino, G., Bari, G., Basile, M., Berezinsky, V. S., Bersani, F., Bertaina, M., Bertoni, R., Bruni, G., Cara Romeo, G., Castagnoli, C., Castellina, A., Chiavassa, A., Chinellato, J. A., Cifarelli, L., Cindolo, F., Contin, A., Dadykin, V. L., Dos Santos, L. G., Enikeev, R. I., Fulgione, W., Galeotti, P., Ghia, P., Giusti, P., Gomez, F., Granella, R., Grianti, F., Gurentsov, V. I., Iacobucci, G., Inoue, N., Kemp, E., Khalchukov, F. F., Korolkova, E. V., Korchaguin, P. V., Korchaguin, V. B., Kudryavtsev, V. A., Luvisetto, M., Malguin, A. S., Massam, T., Mengotti Silva, N., Morello, C., Nania, R., Navarra, G., Periale, L., Pesci, A., Picchi, P., Pless, I. A., Ryazhskaya, O. G., Saavedra, O., Saitoh, K., Sartorelli, G., Selvi, M., Taborgna, N., Talochkin, V. P., Trinchero, G. C., Tsuji, S., Turtelli, A., Vallania, P., Vernetto, S., Vigorito, C., Votano, L., Wada, T., Weinstein, R., Widgoff, M., Yakushev, V. F., Yamamoto, I., Zatsepin, G. T., and Zichich, A.

Published
2003
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24. First observation of high-energy cosmic-ray events obtained in coincidence between EAS-TOP and LVD at Gran Sasso

Author

Aglietta, M., Alpat, B., Alyea, E. D., Alessandro, B., Antonioli, P., Anzivino, G., Arneodo, F., Badino, G., Ban, Y., Bari, G., Basile, M., Bellagamba, L., Benelli, A., Berezinsky, V. S., Bergamasco, L., Bianco, S., Bizzetti, A., Bruni, G., Campos Fauth, A., Cao, Y., Cara Romeo, G., Casaccia, R., Castagnoli, C., Castellina, A., Cattadori, C., Chen, K., Chen, R., Chinellato, J. A., Chiavassa, A., Cifarelli, L., Cini, G., Cong, S., Contin, A., Dadikin, V. L., Dardo, M., De Silva, A., D’Ettorre Piazzoli, B., Deutsch, M., Di Sciascio, G., Dos Santos, L. G., Enikeev, R. I., Fabbri, F. L., Fulgione, W., Galeotti, P., Ghia, P. L., Giusti, P., Grianti, F., Gu, S., Hafen, E. S., Haridas, P., Iacobucci, G., Iacovacci, M., Inoue, N., Khalchukov, F. F., Korolkova, E. V., Kortchaguin, P. V., Kortchaguin, V. B., Kudryavtsev, V. A., Landi, G., Lau, K., Lin, X., Lu, L., Ma, J., Ma, Z., Maccarrone, G., Malguin, A. S., Mannocchi, G., Mao, Z., Margotti, A., Markov, M. A., Massam, T., Mayes, B., Mengotti Silva, N., Misaki, A., Mo, G. H., Monteleoni, B., Morello, C., Moromisato, J., Nania, R., Navarra, G., Panaro, L., Parks, D., Pelfer, P. G., Periale, L., Picchi, P., Pinna, P., Pinsky, L., Pless, I. A., Pu, M., Pyrlyk, J., Qiu, J., Riccati, L., Ryasny, V. G., Ryazhskaya, O. G., Saavedra, O., Saitoh, K., Sanders, D., Sartorelli, G., Sarwar, S., Shen, D., Talochkin, V. P., Tang, H., Tang, J., Tian, W., Trinchero, G. C., Turtelli, A., Uman, I., Vallania, P., Vernetto, S., von Goeler, E., Votano, L., Wada, T., Wang, F., Wang, H., Wang, S., Weathers, R., Weinstein, R., Widgoff, M., Xu, L., Xu, Z., Yakushev, V. F., Yamamoto, I., Yi, G., Zallo, A., Zatsepin, G. T., Zhou, X., Zhu, Q., Zhu, X., Zhuan, B., Zichichi, A., and EAS-TOP and LVD Collaborations

Published
1992
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25. The most powerful scintillator supernovae detector: LVD

Author

Aglietta, M., Alpat, B., Alyea, E. D., Antonioli, P., Anzivino, G., Badino, G., Ban, Y., Bari, G., Basile, M., Benelli, A., Berezinsky, V. S., Bergamasco, L., Bianco, S., Bizzetti, A., Bruni, G., Cao, Y., Cara Romeo, G., Casaccia, R., Castagnoli, C., Castellina, A., Chen, K., Chen, R., Chinellato, J. A., Cifarelli, L., Cini, G., Cong, S., Contin, A., Dadikin, V. L., Dardo, M., De Silva, A., Deutsch, M., Dos Santos, L. G., Enikeev, R. I., Fabbri, F. L., Fulgione, W., Galeotti, P., Ghia, P. L., Giusti, P., Grianti, F., Gu, S., Hafen, E. S., Haridas, P., Iacobucci, G., Inoue, N., Khalchukov, F. F., Korolkova, E. V., Kortchaguin, P. V., Kortchaguin, V. B., Kudryavtsev, V. A., Landi, G., Lau, K., Lin, X., Lu, L., Ma, J., Ma, Z., Maccarrone, G., Malguin, A. S., Mao, Z., Markov, M. A., Massam, T., Mayes, B., Mengotti Silva, N., Misaki, A., Mo, G. H., Monteleoni, B., Morello, C., Moromisato, J., Nania, R., Navarra, G., Panaro, L., Parks, D., Pelfer, P. G., Periale, L., Picchi, P., Pinna, P., Pinsky, L., Pless, I. A., Pu, M., Pyrlyk, J., Qiu, J., Ryasny, V. G., Ryazhskaya, O. G., Saavedra, O., Saitoh, K., Sanders, D., Sartorelli, G., Sarwar, S., Shen, D., Talochkin, V. P., Tang, H., Tang, J., Tian, W., Trinchero, G. C., Turtelli, A., Uman, I., Vallania, P., Vernetto, S., von Goeler, E., Votano, L., Wada, T., Wang, F., Wang, H., Wang, S., Weathers, R., Weinstein, R., Widgoff, M., Xu, L., Xu, Z., Yakushev, V. F., Yamamoto, I., Yi, G., Zallo, A., Zatsepin, G. T., Zhou, X., Zhu, Q., Zhu, X., Zhuan, B., and Zichichi, A.

Published
1992
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27. A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation

Author

Nikiforow, S., primary, Kim, H. T., additional, Daley, H., additional, Reynolds, C., additional, Jones, K. T., additional, Armand, P., additional, Ho, V. T., additional, Alyea, E. P., additional, Cutler, C. S., additional, Ritz, J., additional, Antin, J. H., additional, Soiffer, R. J., additional, and Koreth, J., additional

Published
2016
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28. The exclusive channel π-π-π+p in π-p interactions at 147 GeV/c

Author

Fong, D., Heller, M., Shapiro, A. M., Widgoff, M., Bruyant, F., Bogert, D., Johnson, M., Burnstein, R., Fu, C., Petersen, D., Robertson, M., Rubin, H., Sard, R., Snyder, A., Tortora, J., Alyea, E. D., Chien, C. -Y., Lucas, P., Pevsner, A., Zdanis, R., Brau, J., Grunhaus, J., Hafen, E. S., Hulsizer, R. I., Karshon, U., Kistiakowsky, V., Levy, A., Napier, A., Pless, I. A., Silverman, J. P., Trepagnier, P. C., Wolfson, J., Yamamoto, R. K., Cohn, H. O., Ou, T. C., Plano, R. J., Watts, T. L., Brucker, E. B., Koller, E., Stamer, P., Taylor, S., Bugg, W. M., Condo, C., Handler, T., Hart, E., Kraybill, H., Ljung, D., Ludlam, T., and Taft, H. D.

Published
1976
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31. Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation

Author

Murase, K., primary, Kim, H. T., additional, Bascug, O. R. G., additional, Kawano, Y., additional, Ryan, J., additional, Matsuoka, K.-i., additional, Davids, M. S., additional, Koreth, J., additional, Ho, V. T., additional, Cutler, C., additional, Armand, P., additional, Alyea, E. P., additional, Blazar, B. R., additional, Antin, J. H., additional, Soiffer, R. J., additional, Letai, A., additional, and Ritz, J., additional

Published
2014
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32. An energy signature for very deep underground muons observed by the LVD experiment

Author

Aglietta, M., Alpat, B., Alyea, E. D., Antonioli, P., Badino, G., Bari, G., Basile, M., Berezinsky, V. S., Bersani, F., Bertaina, M., Bertoni, R., Bonoli, G., Bosco, A., Bruni, G., Cara Romeo, G., Castagnoli, C., Castellina, A., Chiavassa, A., Chinellato, J. A., Cifarelli, L., Cindolo, F., Conforto, G., Contin, A., Dadykin, V. L., Desilva, A., Deutsch, M., Dominici, P., Dos Santos, L. G., Emaldi, L., Enikeev, R. I., Fabbri, F. L., Fulgione, W., Galeotti, P., Ghetti, C., Ghia, P. L., Giusti, P., Granella, R., Grianti, F., Guidi, G., Hafen, Elizabeth S., Haridas, P., Iacobucci, G., Inoue, N., Kemp, E., Khalchukov, F. F., Korolkova, E. V., Korchagin, P. V., Korchagin, V. B., Kudryavtsev, V. A., Lau, K., Luvisetto, M., Maccarone, G., Malguin, A. S., Mantovani, R., Massam, T., Mayes, B., Megna, A., Melagrana, C., Mengotti Silva, N., Morello, C., Moromisato, J., Nania, R., Navarra, G., Panaro, L., Periale, L., Pesci, A., Picchi, P., Pinsky, Lawrence S., Pless, I. A., Pyrlik, J., Ryasnii, V. G., Ryazhskaya, O. G., Saavedra, O., Marco Selvi, Saitoh, K., Santini, S., Sartorelli, G., Taborgna, N., Talochkin, V. P., Tang, J., Trinchero, G. C., Tsuji, S., Turtelli, A., Uman, I., Vallania, P., Buren, G., Vernetto, S., Vetrano, F., Vigorito, C., Goeler, E., Votano, L., Wada, T., Weinstein, R., Widgoff, M., Yakushev, V. F., Yamamoto, I., Zatsepin, G. T., and Zichichi, A.

Subjects
Astrophysics and Astronomy
Published
1997

33. Long-term follow-up of reduced-intensity allogeneic stem cell transplantation for chronic lymphocytic leukemia: prognostic model to predict outcome

Author

Brown, J R, primary, Kim, H T, additional, Armand, P, additional, Cutler, C, additional, Fisher, D C, additional, Ho, V, additional, Koreth, J, additional, Ritz, J, additional, Wu, C, additional, Antin, J H, additional, Soiffer, R J, additional, Gribben, J G, additional, and Alyea, E P, additional

Published
2012
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35. Neutrino-induced and Atmospheric Single-muon Fluxes Measured Over 5 Decades of Intensity By Lvd At Gran-sasso-laboratory

Author

Aglietta, M., Alpat, B., Alyea, E. D., Antonioli, P., Badino, Giovanni, Ban, Y., Bari, G., Basile, M., Benelli, A., Berezinsky, V. S., Bertoni, R., Bianco, S., Bizzeti, A., Bosco, A., Brugnola, G., Bruni, G., Cao, Y., Romeo, G. C., Castagnoli, Carlo, Castellina, A., Chen, K., Chen, R., Chiavassa, Andrea, Chinellato, J. A., Cifarelli, L., Cindolo, F., Conforto, G., Cong, S., Contin, A., Dadykin, V. L., Desiati, P., Depasquale, S., Desilva, A., Deutsch, M., Dominici, P., Dossantos, L. G., Enikeev, R. I., Fabbri, F. L., Fulgione, W., Galeotti, Piero, Ghia, P., Giusti, P., Grianti, F., Gu, S., Guidi, G., Guo, Y., Hafen, E. S., Haridas, P., Iacobucci, G., Inoue, N., Khalchukov, F. F., Korolkova, E. V., Kortchaguin, P. V., Kortchaguin, V. B., Kudryavtsev, V. A., Landi, G., Lau, K., Lin, X., Lu, L., Luvisetto, M., Ma, J., Ma, Z., Maccarrone, G., Malguin, A. S., Mantovani, R., Mao, Z., Markov, M. A., Massam, T., Mayes, B., Melagrana, C., Silva, N. M., Misaki, A., G. H., Mo, Monteleoni, B., Morello, C., Moromisato, J., Nania, R., Navarra, Gianni Maria, Panaro, L., Parks, D., Pelfer, P. G., Periale, L., Picchi, Pio, Pinna, P., Pinsky, L., Pless, I. A., Pu, M., Pyrlik, J., Santini, S., Sartorelli, G., Shen, D., Taborgna, N., Talochkin, V. P., Tang, H., Tang, J., Tian, W., Trinchero, G. C., Turtelli, A., Uman, I., Vallania, P., Vernetto, S., Vetrano, F., Vigorito, Carlo Francesco, Vongoeler, E., Votano, L., Wada, T., Wang, F., Wang, H., Wang, S., Weinstein, R., Widgoff, M., Xu, L., Xu, Z., Yakushev, V. F., Yamamoto, I., Zatsepin, G. T., Zhou, X., Zhu, Q., Zhu, X., Zhuang, B., and Zichichi, A.

Subjects
cosmic rays, muons, neutrino interaction
Published
1995

36. Ex Vivo Treatment of Hematopoietic Stem Cells With 16,16-Dimethyl Prostaglandin E2 (FT1050) Improves Engraftment and Hematopoietic Reconstitution

Author

Cutler, C.S., primary, Desponts, C., additional, Robbins, D., additional, North, T.E., additional, Goessling, W., additional, Kao, G., additional, Ritz, J., additional, Ballen, K.K., additional, Antin, J.H., additional, Spitzer, T.R., additional, SoifferChenY.-B.A., R.J., additional, Ho, V.T., additional, Armand, P., additional, Koreth, J., additional, Alyea, E., additional, McAfee, S., additional, Dey, B.R., additional, Shoemaker, D., additional, and Multani, P.S., additional

Published
2011
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37. Immune Reconstitution After Double Umbilical Cord Blood Stem Cell Transplantation: Comparison With Peripheral Blood Stem Cell Transplantation

Author

Jacobson, C., primary, Turki, A., additional, McDonough, S., additional, Stevenson, K., additional, Kim, H., additional, Herrera, M., additional, Reynolds, C., additional, Alyea, E., additional, Ho, V., additional, Koreth, J., additional, Soiffer, R., additional, Antin, J., additional, Ballen, K., additional, Cutler, C., additional, and Ritz, J., additional

Published
2011
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38. Anti-HLA Antibodies Predict Graft Failure, Time to Engraftment and Umbilical Cord Unit Dominance in Double Umbilical Cord Blood Transplantation

Author

Cutler, C., primary, Kim, H.T., additional, Sun, L., additional, Sese, D., additional, Kao, G., additional, Vasquez, M., additional, Armand, P., additional, Koreth, J., additional, Ho, V.T., additional, Alyea, E., additional, Soiffer, R.J., additional, Ballen, K., additional, Ritz, J., additional, Milford, E., additional, and Antin, J.H., additional

Published
2011
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40. Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis

Author

Cutler, C, primary, Stevenson, K, additional, Kim, H T, additional, Brown, J, additional, McDonough, S, additional, Herrera, M, additional, Reynolds, C, additional, Liney, D, additional, Kao, G, additional, Ho, V, additional, Armand, P, additional, Koreth, J, additional, Alyea, E, additional, Dey, B R, additional, Attar, E, additional, Spitzer, T, additional, Boussiotis, V A, additional, Ritz, J, additional, Soiffer, R, additional, Antin, J H, additional, and Ballen, K, additional

Published
2010
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42. Serologic Markers of Effective Tumor Immunity against Chronic Lymphocytic Leukemia Include Nonmutated B-Cell Antigens

Author

Marina, O., primary, Hainz, U., additional, Biernacki, M. A., additional, Zhang, W., additional, Cai, A., additional, Duke-Cohan, J. S., additional, Liu, F., additional, Brusic, V., additional, Neuberg, D., additional, Kutok, J. L., additional, Alyea, E. P., additional, Canning, C. M., additional, Soiffer, R. J., additional, Ritz, J., additional, and Wu, C. J., additional

Published
2010
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43. Prediction of VOD Using Biomarkers of Endothelial Injury

Author

Cutler, C., primary, Aldridge, J., additional, Kim, H.T., additional, Ayanian, S., additional, Bradwin, G., additional, Revta, C., additional, Murga, G., additional, Ho, V., additional, Alyea, E., additional, Koreth, J., additional, Armand, P., additional, Richardson, P.G., additional, Soiffer, R., additional, Ritz, J., additional, and Antin, J.H., additional

Published
2009
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44. Prediction of VOD Using Biomarkers of Endothelial Injury.

Author

Cutler, Corey, primary, Aldridge, J., additional, Kim, H. T., additional, Ayanian, S., additional, Bradwin, G., additional, Revta, C., additional, Murga, G., additional, Ho, V., additional, Alyea, E., additional, Koreth, J., additional, Armand, P., additional, Richardson, P. G., additional, Soiffer, R. J., additional, Ritz, J., additional, and Antin, J. H., additional

Published
2008
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46. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation

Author

Haspel, R L, primary, Kao, G, additional, Yeap, B Y, additional, Cutler, C, additional, Soiffer, R J, additional, Alyea, E P, additional, Ho, V T, additional, Koreth, J, additional, Dey, B R, additional, McAfee, S L, additional, Attar, E C, additional, Spitzer, T, additional, Antin, J H, additional, and Ballen, K K, additional

Published
2007
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49. Vaccine-associated immune and WT-1 responses are associated with better relapse-free survival in patients with AML in remission treated with a GM-CSF secreting leukemia vaccine and autologous stem cell transplant (ASCT)

Author

Borrello, I., primary, Levitsky, H., additional, Damon, L., additional, Linker, C., additional, Deangelo, D., additional, Alyea, E., additional, Stock, W., additional, Sher, D., additional, Donnelly, A., additional, and Hege, K., additional

Published
2005
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50. Rituxan for steroid-refractory chronic GVHD

Author

Cutler, C., primary, Miklos, D., additional, Lee, S.J., additional, Woo, S.-B., additional, Treister, N., additional, Bienfang, D., additional, Klickstein, L., additional, Levin, J., additional, Windawi, S., additional, Pasek, M., additional, Ho, V., additional, Ritz, J., additional, Antin, J., additional, Soiffer, R., additional, and Alyea, E., additional

Published
2005
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