7 results on '"Alves da Costa J"'
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2. Nosotros somos testigos. Itinerario espiritual para los laicos de nuestro tiempo.
- Author
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ALVES DA COSTA, J. Artenildo
- Published
- 2009
3. La muerte, la esperanza, la fe.
- Author
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ALVES DA COSTA, J. Artenildo
- Published
- 2009
4. Care around Medical devices: infusion sets and devices
- Author
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Claire Chapuis, Pierrick Bedouch, Valérie Sautou, Lise Bernard, Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), F. Alves da Costa, J. W. Foppe van Mil, A. Alvarez-Risco, Bonnefoy, Stéphanie, F. Alves da Costa, J. W. F. Van Mil, A. Alvarez-Risco, CHU Clermont-Ferrand, J. W. F. Van Mil, and F. Alves da Costa, J. W. Foppe van Mil, A. Alvarez-Risco
- Subjects
Drug ,medicine.medical_specialty ,Intravenous drug ,business.industry ,media_common.quotation_subject ,[SDV]Life Sciences [q-bio] ,education ,Pharmacist ,Patient comfor ,3. Good health ,[SDV] Life Sciences [q-bio] ,03 medical and health sciences ,0302 clinical medicine ,Pharmaceutical care ,030202 anesthesiology ,Hospital Infusion sets ,Medicine ,Medical devices ,030212 general & internal medicine ,business ,Intensive care medicine ,ComputingMilieux_MISCELLANEOUS ,media_common ,Patient comfort - Abstract
International audience; Patients who receive intravenous (IV) medications as a rule should be given special attention. As pharmacists we want to assist to optimize the treatment and prevent medication errors. Intravenous drug administration is complex and subject to iatrogenic risk. The choice of the appropriate medical devices is therefore important in each infusion setup. By his knowledge of injectable drugs and medical devices, the pharmacist can contribute to the selection of appropriate tools to control infusion rates, avoid drug incompatibilities, container–content interactions, prevent allergies or infectious complications, and improve the patient comfort.
- Published
- 2018
5. Assessment of acute toxicity, genotoxicity, and anti-inflammatory activity of SteLL, a lectin from Schinus terebinthifolia Raddi. Leaves, in mice.
- Author
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de Oliveira Marinho A, Alves da Costa J, Silva Dos Santos AN, Cavalcanti de Barros M, Pimentel CDN, Arnaldo da Silva A, Guedes Paiva PM, Napoleão TH, and Leite de Siqueira Patriota L
- Subjects
- Animals, Mice, Male, Plant Lectins pharmacology, Plant Lectins isolation & purification, Toxicity Tests, Acute, Peritonitis drug therapy, Peritonitis chemically induced, Micronucleus Tests, Female, Carrageenan, Comet Assay, DNA Damage drug effects, Dose-Response Relationship, Drug, Schinus, Plant Leaves, Anacardiaceae chemistry, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents isolation & purification, Edema drug therapy, Edema chemically induced, Plant Extracts pharmacology
- Abstract
Ethnopharmacology Relevance: Schinus terebinthifolia Raddi (Anacardiaceae), known as Brazilian pepper tree, stands out as a medicinal plant widely used in traditional medicine. The leaves are popularly used as anti-inflammatory agent and to relieve inflammatory conditions such as bronchitis, ulcers, and wounds, for example., Aim of the Study: The present study evaluated the acute toxicity, genotoxicity, and anti-inflammatory activity of S. terebinthifolia leaf lectin (SteLL) in mice (Mus musculus)., Materials and Methods: In the acute toxicity assay, the animals were treated intraperitoneally (i.p.) or orally (per os) with a single dose of 100 mg/kg. Genotoxicity was assessed by the comet and micronucleus assays. Carrageenan-induced peritonitis and paw edema models were used to evaluate the anti-inflammatory effects of SteLL (1, 5 and 10 mg/kg, i.p.)., Results: No animal died and no signs of intoxication or histopathological damage were observed in the acute toxicity assay. Genotoxic effect was not detected. In peritonitis assay, SteLL reduced in 56-69% leukocyte migration to the peritoneal cavity; neutrophil count decreased by 25-32%, while mononuclear cell count increased by 67-74%. SteLL promoted a notable reduction of paw edema after 4 h (61.1-63.4%). Morphometric analysis showed that SteLL also decreased the thickness of epidermal edema (30.2-40.7%). Furthermore, SteLL decreased MPO activity, plasma leakage, NO release, and modulated cytokines in both peritoneal fluid and paw homogenate., Conclusion: SteLL did not induce acute toxicity or genotoxicity in mice and stands out as a promising candidate in the development of new phytopharmaceuticals with anti-inflammatory action., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
6. The lectin from Schinus terebinthifolia leaf (SteLL) reduces immobility of mice on the tail suspension test dependent on the monoaminergic and nitric oxide signaling.
- Author
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Raíssa Ferreira de Lima B, Leite de Siqueira Patriota L, de Oliveira Marinho A, Alves da Costa J, Henrique Napoleão T, Melgarejo da Rosa M, and Maria Guedes Paiva P
- Subjects
- Mice, Animals, Schinus, Hindlimb Suspension, Plant Leaves, Carbohydrates, Depression drug therapy, Swimming, Nitric Oxide, Lectins
- Abstract
Depression underlies a common psychiatric disorder that has been rising in the diagnosis of long-term disabilities worldwide. Natural products have been studied as an antidepressant and anxiolytic agents aiming to make available new options for the daily basis treatment of those psychological disorders. SteLL is a lectin extracted from Schinus terebinthifolia leaf that has been revealed as an antimicrobial, immunomodulatory, antitumor, and antinociceptive agent. Nonetheless, the efficacy of SteLL in the treatment of depression has not yet been explored. In view of this, the aim of this study was to investigate the effect of SteLL in an acute protocol for symptoms of depression using the tail suspension test (TST) to assess despair. Administration of SteLL (1, 2 e 4 mg/kg) significantly diminished the immobility time of animals in the TST and this anti-immobility action was dependent on the carbohydrate-recognizing domain (CRD) since the prior incubation with casein (an inhibitor of SteLL carbohydrate-binding property) blocked the effect. SteLL effect was also reversed by pre-treatment with pharmacological antagonists of α2-adrenoceptor, 5-HT2A/2C serotonin receptor, and D1 dopamine receptor as well as by a selective inhibitor of iNOS (aminoguanidine). l-arginine, a precursor of NO, potentiated SteLL anti-immobility effect. In a subacute evaluation, the anti-immobility effect of SteLL persisted after seven days of treatment. Our findings suggest a role of SteLL in the modulation of depression mostly through monoaminergic and nitric oxide signaling., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
7. Yellow Fever: Factors Associated with Death in a Hospital of Reference in Infectious Diseases, São Paulo, Brazil, 2018.
- Author
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Ribeiro AF, Cavalin RF, Abdul Hamid Suleiman JM, Alves da Costa J, Januaria de Vasconcelos M, Sant'Ana Málaque CM, and Sztajnbok J
- Subjects
- Adolescent, Adult, Brazil epidemiology, Child, Female, Hospitals, Humans, Male, Middle Aged, Retrospective Studies, Yellow Fever epidemiology, Young Adult, Yellow Fever diagnosis, Yellow Fever mortality
- Abstract
Faced with the reemergence of yellow fever (YF) in the metropolitan region of São Paulo, Brazil, we developed a retrospective study to describe the cases of YF attended at the Institute of Infectology Emilio Ribas from January to March 2018 and analyze the factors associated with death, from the information obtained in the hospital epidemiological investigation. A total of 72 cases of sylvatic YF were confirmed, with 21 deaths (29.2% lethality rate). Cases were concentrated in males (80.6%) and in the age group of 30 to 59 years (56.9%). Two logistic regression models were performed, with continuous variables adjusted for the time between onset of symptoms and hospitalization. The first model indicated age (odds ratios
adjusted [ORadj ]: 1.038; CI 95%: 1.008-1.212), aspartate aminotransferase (AST) (ORadj : 1.038; CI 95%: 1.005-1.072), and creatinine (ORadj : 2.343; CI 95%: 1.205-4.553) were independent factors associated with mortality. The second model indicated age (ORadj : 1.136; CI 95%: 1.013-1.275), alanine aminotransferase (ALT) (ORadj : 1.118; CI 95%: 1.018-1.228), and creatinine (ORadj : 2.835; CI 95%: 1.352-5,941). The risk of death in the model with continuous variables was calculated from the increase of 1 year (age), 1 mg/dL (creatinine), and 100 U/L for AST and ALT. Another logistic regression analysis with dichotomous variables indicated AST > 1,841 IU/L (ORadj : 12.92; CI 95%: 1.50-111.37) and creatinine > 1.2 mg/dL (ORadj : 81.47; CI 95%: 11.33-585.71) as independent factors associated with death. These results may contribute to the appropriate clinical management of patients with YF in health-care services and improve the response to outbreaks and public health emergencies.- Published
- 2019
- Full Text
- View/download PDF
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