29 results on '"Alvarez-Sanchez M"'
Search Results
2. Suturas transconjuntivales del tapete escleral en maculopatía hipotónica tardía tras esclerectomía profunda no perforante
- Author
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Galindo-Bocero, J., Álvarez-Sánchez, M., Rodríguez-Balsera, C., and Saa, J.
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- 2018
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3. The effects of environmental factors on the virulence of Trichomonas vaginalis
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Figueroa-Angulo, Elisa E., Rendón-Gandarilla, Francisco J., Puente-Rivera, Jonathan, Calla-Choque, Jaeson S., Cárdenas-Guerra, Rosa E., Ortega-López, Jaime, Quintas-Granados, Laura I., Alvarez-Sánchez, M. Elizbeth, and Arroyo, Rossana
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- 2012
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4. Oral Administration of Hyperimmune Anti-Cryptosporidium parvum Ovine Colostral Whey Confers a High Level of Protection against Cryptosporidiosis in Newborn NMRI Mice
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Martín-Gómez, S., Álvarez-Sánchez, M. A., and Rojo-Vázquez, F. A.
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- 2005
5. Assessing the non-motor symptoms of Parkinsonʼs disease: MDS-UPDRS and NMS Scale
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Martinez-Martin, P., Chaudhuri, K. R., Rojo-Abuin, J. M., Rodriguez-Blazquez, C., Alvarez-Sanchez, M., Arakaki, T., Bergareche-Yarza, A., Chade, A., Garretto, N., Gershanik, O., Kurtis, M. M., Martinez-Castrillo, J. C., Mendoza-Rodriguez, A., Moore, H. P., Rodriguez-Violante, M., Singer, C., Tilley, B. C., Huang, J., Stebbins, G. T., and Goetz, C. G.
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- 2015
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6. Systematic pancreatic stenting after endoscopic snare papillectomy may reduce the risk of postinterventional pancreatitis
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Napoléon, Bertrand, Alvarez-Sanchez, M. Victoria, Leclercq, Philippe, Mion, François, Pialat, Jean, Gincul, Rodica, Ribeiro, Daniel, Cambou, Marie, Lefort, Christine, Rodríguez-Girondo, Mar, and Scoazec, Jean Yves
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- 2013
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7. Patients’ evaluation of the radiation oncology department
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Corral Garcia, A., primary, Carnicero Montoro, S., additional, Márquez Parro, R., additional, Mancha Pescador, M., additional, Fernández Romarategui, N., additional, Vázquez Camello, V., additional, Cantarero Valenzuela, N., additional, Alvarez Sanchez, M., additional, Gavela Robles, N., additional, Santiago Novillo, A., additional, Martín Jorge, N., additional, Gómez Fervienza, J., additional, Principe Mellado, M., additional, Arminio Diaz, E., additional, Rodríguez Pérez, A., additional, López Fernández, A., additional, Rodríguez Rodríguez, C., additional, Bermudez Luna, R., additional, Ludeña, B., additional, de Torres, M., additional, Garcia, T., additional, Caballero, B., additional, and Martín, G., additional
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- 2013
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8. Dosimetric effect of daily setup correction in prostate IMRT
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Corral Garcia, A., primary, Gómez Fervienza, J., additional, Marquez Parro, R., additional, Martin Jorge, N., additional, Vázquez Camello, V., additional, Cantarero Valenzuela, N., additional, Carnicero Montoro, S., additional, Gavela Robles, N., additional, Mancha Pescador, M., additional, Fenandez Romarategui, N., additional, Alvarez Sanchez, M., additional, Santiago Novillo, A., additional, Principe Mellado, M., additional, Arminio Diaz, E., additional, Ludeña, B., additional, Torres, M., additional, Rodriguez, A., additional, López, A., additional, Rodríguez, C., additional, and Bermudez, R., additional
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- 2013
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9. Assessing the non-motor symptoms of Parkinson's disease: MDS-UPDRS and NMS Scale
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Martinez-Martin, P., primary, Chaudhuri, K. R., additional, Rojo-Abuin, J. M., additional, Rodriguez-Blazquez, C., additional, Alvarez-Sanchez, M., additional, Arakaki, T., additional, Bergareche-Yarza, A., additional, Chade, A., additional, Garretto, N., additional, Gershanik, O., additional, Kurtis, M. M., additional, Martinez-Castrillo, J. C., additional, Mendoza-Rodriguez, A., additional, Moore, H. P., additional, Rodriguez-Violante, M., additional, Singer, C., additional, Tilley, B. C., additional, Huang, J., additional, Stebbins, G. T., additional, and Goetz, C. G., additional
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- 2013
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10. FEMALE (IN)FERTILITY
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Kanta Goswami, S., primary, Banerjee, S., additional, Saha, P., additional, Chakraborty, P., additional, Kabir, S. N., additional, Karimzadeh, M. A., additional, Mohammadian, F., additional, Mashayekhy, M., additional, Saldeen, P., additional, Kallen, K., additional, Karlstrom, P. O., additional, Rodrigues-Wallberg, K. A., additional, Salerno, A., additional, Nazzaro, A., additional, Di Iorio, L., additional, Marino, S., additional, Granato, C., additional, Landino, G., additional, Pastore, E., additional, Ghoshdastidar, B., additional, Chakraborty, C., additional, Ghoshdastidar, B. N., additional, Ghoshdastidar, S., additional, Partsinevelos, G. A., additional, Papamentzelopoulou, M., additional, Mavrogianni, D., additional, Marinopoulos, S., additional, Dinopoulou, V., additional, Theofanakis, C., additional, Anagnostou, E., additional, Loutradis, D., additional, Franz, C., additional, Nieuwland, R., additional, Montag, M., additional, Boing, A., additional, Rosner, S., additional, Germeyer, A., additional, Strowitzki, T., additional, Toth, B., additional, Mohamed, M., additional, Vlismas, A., additional, Sabatini, L., additional, Caragia, A., additional, Collins, B., additional, Leach, A., additional, Zosmer, A., additional, Al-Shawaf, T., additional, Beyhan, Z., additional, Fisch, J. D., additional, Danner, C., additional, Keskintepe, L., additional, Aydin, Y., additional, Ayca, P., additional, Oge, T., additional, Hassa, H., additional, Papanikolaou, E., additional, Pados, G., additional, Grimbizis, G., additional, Bili, H., additional, Karastefanou, K., additional, Fatemi, H., additional, Kyrou, D., additional, Humaidan, P., additional, Tarlatzis, B., additional, Gungor, F., additional, Karamustafaoglu, B., additional, Iyibozkurt, A. C., additional, Ozsurmeli, M., additional, Bastu, E., additional, Buyru, F., additional, Di Emidio, G., additional, Vitti, M., additional, Mancini, A., additional, Baldassarra, T., additional, D'Alessandro, A. M., additional, Polsinelli, F., additional, Tatone, C., additional, Leperlier, F., additional, Lammers, J., additional, Dessolle, L., additional, Lattes, S., additional, Barriere, P., additional, Freour, T., additional, Elodie, P., additional, Assou, S., additional, Van den Abbeel, E., additional, Arce, J. C., additional, Hamamah, S., additional, Dechaud, H., additional, Haouzi, D., additional, Tiplady, S., additional, Johnson, S., additional, Jones, G., additional, Ledger, W., additional, Eizadyar, N., additional, Ahmad Nia, S., additional, Seyed Mirzaie, M., additional, Azin, S. A., additional, Yazdani Safa, M., additional, Onaran, Y., additional, Iltemir Duvan, C., additional, Keskin, E., additional, Ayrim, A., additional, Kafali, H., additional, Kadioglu, N., additional, Guler, B., additional, Var, T., additional, Cicek, M. N., additional, Batioglu, A. S., additional, Lichtblau, I., additional, Olivennes, F., additional, de Mouzon, J., additional, Dumont, M., additional, Junca, A. M., additional, Cohen-Bacrie, M., additional, Hazout, A., additional, Belloc, S., additional, Cohen-Bacrie, P., additional, Allegra, A., additional, Marino, A., additional, Sammartano, F., additional, Coffaro, F., additional, Scaglione, P., additional, Gullo, S., additional, Volpes, A., additional, Prisant, N., additional, Saare, M., additional, Vaidla, K., additional, Salumets, A., additional, Peters, M., additional, Jindal, U. N., additional, Thakur, M., additional, Shvell, V., additional, Diamond, M. P., additional, Awonuga, A. O., additional, Veljkovic, M., additional, Macanovic, B., additional, Milacic, I., additional, Borogovac, D., additional, Arsic, B., additional, Pavlovic, D., additional, Lekic, D., additional, Bojovic Jovic, D., additional, Garalejic, E., additional, Jayaprakasan, K., additional, Eljabu, H., additional, Hopkisson, J., additional, Campbell, B., additional, Raine-Fenning, N., additional, Kop, P., additional, van Wely, M., additional, Mol, B. W., additional, Melker, A. A., additional, Janssens, P. M. W., additional, Nap, A., additional, Arends, B., additional, Roovers, J. P. W. R., additional, Ruis, H., additional, Repping, S., additional, van der Veen, F., additional, Mochtar, M. H., additional, Sargin, A., additional, Yilmaz, N., additional, Gulerman, C., additional, Guven, A., additional, Polat, B., additional, Ozel, M., additional, Bardakci, Y., additional, Vidal, C., additional, Giles, J., additional, Remohi, J., additional, Pellicer, A., additional, Garrido, N., additional, Javdani, M., additional, Fallahzadeh, H., additional, Davar, R., additional, Sheibani, H., additional, Leary, C., additional, Killick, S., additional, Sturmey, R. G., additional, Kim, S. G., additional, Lee, K. H., additional, Park, I. H., additional, Sun, H. G., additional, Lee, J. H., additional, Kim, Y. Y., additional, Choi, E. M., additional, Van Loendersloot, L. L., additional, Van Wely, M., additional, Bossuyt, P. M. M., additional, Van Der Veen, F., additional, Roychoudhury Sarkar, M., additional, Roy, D., additional, Sahu, R., additional, Bhattacharya, J., additional, Eguiluz Gutierrez- Barquin, I., additional, Sanchez Sanchez, V., additional, Torres Afonso, A., additional, Alvarez Sanchez, M., additional, De Leon Socorro, S., additional, Molina Cabrillana, J., additional, Seara Fernandez, S., additional, Garcia Hernandez, J. A., additional, Ozkan, Z. S., additional, Simsek, M., additional, Kumbak, B., additional, Atilgan, R., additional, Sapmaz, E., additional, Agirregoikoa, J. A., additional, DePablo, J. L., additional, Abanto, E., additional, Gonzalez, M., additional, Anarte, C., additional, Barrenetxea, G., additional, Aleyasin, A., additional, Mahdavi, A., additional, Agha Hosseini, M., additional, Safdarian, L., additional, Fallahi, P., additional, Bahmaee, F., additional, Sarikaya, E., additional, Segawa, T., additional, Teramoto, S., additional, Tsuchiyama, S., additional, Miyauchi, O., additional, Watanabe, Y., additional, Ohkubo, T., additional, Shozu, M., additional, Ishikawa, H., additional, Yelian, F., additional, Papaioannou, S., additional, Knowles, T., additional, Aslam, M., additional, Milnes, R., additional, Takashima, A., additional, Takeshita, N., additional, Kinoshita, T., additional, Chapman, M. G., additional, Kilani, S., additional, Dadras, N., additional, Parsanezhad, M. E., additional, Zolghadri, J., additional, Younesi, M., additional, Floehr, J., additional, Dietzel, E., additional, Wessling, J., additional, Neulen, J., additional, Rosing, B., additional, Tan, S., additional, Jahnen-Dechent, W., additional, Lee, K. S., additional, Joo, J. K., additional, Son, J. B., additional, Joo, B. S., additional, Risquez, F., additional, Confino, E., additional, Llavaneras, F., additional, Marval, I., additional, D'Ommar, G., additional, Gil, M., additional, Risquez, M., additional, Lozano, L., additional, Paublini, A., additional, Piras, M., additional, Risquez, A., additional, Prochazka, R., additional, Blaha, M., additional, Nemcova, L., additional, Weghofer, A., additional, Kim, A., additional, Barad, D. H., additional, Gleicher, N., additional, Kilic, Y., additional, Ergun, B., additional, Howard, B., additional, Weiss, H., additional, Doody, K., additional, Schafer, C., additional, Ensslen, S., additional, Denecke, B., additional, Veitinger, T., additional, Spehr, M., additional, Tropartz, T., additional, Tolba, R., additional, Egert, A., additional, Schorle, H., additional, Alanya, S., additional, and Yumru, H., additional
- Published
- 2012
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11. Contrast-enhanced harmonic endoscopic ultrasound in solid lesions of the pancreas: results of a pilot study
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Napoleon, B., primary, Alvarez-Sanchez, M., additional, Gincoul, R., additional, Pujol, B., additional, Lefort, C., additional, Lepilliez, V., additional, Labadie, M., additional, Souquet, J., additional, Queneau, P., additional, Scoazec, J., additional, Chayvialle, J., additional, and Ponchon, T., additional
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- 2010
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12. Positioning protocol image guided for radiotheraphy
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Gómez Fervienza, J., Corral García, A., Márquez Parro, R., Mancha Pescador, M., Ferdandez de Romarategui, N., Martín Jorge, N., Vázquez Camello, V., Cantarero Valenzuela, N., Alvarez Sánchez, M., Carnicero Montoro, S., Gavela Robles, N., Santiago Novillo, A., Rodriguez Perez, A., López Fernandez, A., Rodríguez Rodríguez, C., Bermudez Luna, R., and Martín Martín, G.
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- 2013
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13. EUS 2010 in Shanghai - Highlights and Scientific Abstracts.
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Leong Ang, T., De Angelis, C. G., Alvarez-Sanchez, M. V., Chak, A., Chang, K. J., Chen, R., Eloubeidi, M., Herth, F. J. F., Hirooka, K., Irisawa, A., Jin, Z., Kida, M., Kitano, M., Levy, M. J., Maguchi, H., Napoleon, B. V., Penman, I., Seewald, S., Wang, G., and Wallace, M.
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ENDOSCOPIC ultrasonography ,LUNG cancer diagnosis ,MEDIASTINUM diseases ,DIAGNOSIS - Abstract
The article presents abstracts related to endoscopic ultrasound (EUS) which includes the education on EUS in the U.S., the use of EUS with fine needle aspiration for staging of lung cancer, and the diagnosis of mediastinal node through EUS with traditional transbronchial needle aspiration.
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- 2011
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14. Contrast-enhanced harmonic endoscopic ultrasound in solid lesions of the pancreas: results of a pilot study.
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Pujol, B., Napoleon, B., Alvarez-Sanchez, M. V., Lefort, C., Gincoul, R., Lepilliez, V., Souquet, J. C., Queneau, P. E., Chayvialle, J. A., Ponchon, T., Labadie, M., and Scoazec, J. Y.
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ULTRASONIC imaging ,ENDOSCOPY ,TISSUE wounds ,PANCREAS ,ADENOCARCINOMA - Abstract
Background and study aims: Distinguishing pancreatic adenocarcinoma from other pancreatic masses remains challenging with current imaging techniques. This prospective study aimed to evaluate the accuracy of a new procedure, imaging the microcirculation pattern of the pancreas by contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) with a new Olympus prototype echo endoscope.Patients and methods: 35 patients presenting with solid pancreatic lesions were prospectively enrolled. All patients had conventional B mode and power Doppler EUS. After an intravenous bolus injection of 2.4 ml of a second-generation ultrasound contrast agent (SonoVue) CEH-EUS was then performed with a new Olympus prototype echo endoscope (xGF-UCT 180). The microvascular pattern was compared with the final diagnosis based on the pathological examination of specimens from surgery or EUS-guided fine-needle aspiration (EUS-FNA) or on follow-up for at least 12 months.Results: The final diagnoses were: 18 adenocarcinomas, 9 neuroendocrine tumors, 7 chronic pancreatitis, and 1 stromal tumor. Power Doppler failed to display microcirculation, whereas harmonic imaging demonstrated it in all cases. Out of 18 lesions with a hypointense signal on CEH-EUS, 16 were adenocarcinomas. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy of hypointensity for diagnosing pancreatic adenocarcinoma were 89 %, 88 %, 88 %, 89 %, and 88.5 %, compared with corresponding values of 72 %, 100 %, 77 %, 100 %, and 86 % for EUS-FNA. Of five adenocarcinomas with false-negative results at EUS-FNA, four had a hypointense echo signal at CEH-EUS.Conclusions: CEH-EUS with the new Olympus prototype device successfully visualizes the microvascular pattern in pancreatic solid lesions, and may be useful for distinguishing adenocarcinomas from other pancreatic masses. [ABSTRACT FROM AUTHOR]- Published
- 2010
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15. Evaluation of official eradication-campaigns data for investigating small-ruminant brucellosis in the province of Leon, Spain
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Lithg-Pereira, P. L., Mainar-Jaime, R. C., Alvarez-Sanchez, M. A., and Rojo-Vazquez, F. A.
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- 2001
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16. 97. Sleep disorders in Parkinson’s disease
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Pedroso Ibañez, I., Bringas Vega, M.L., Álvarez González, L., Álvarez Sánchez, M., Padrón Sánchez, A., and Diaz de la Fé, A.
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- 2008
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17. Relationship between the MDS-UPDRS and quality of life in Parkinson's disease: A large international multicenter study of 3206 patients (the QUALPD study)
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Skorvanek, M., Martinez-Martin, P., Kovacs, N., Zezula, I., Rodriguez-Violante, M., Corvol, J. C., Taba, P., Seppi, K., Levin, O., Schrag, A. E., Foltynie, T., Alvarez-Sanchez, M., Arakaki, T., Aschermann, Z., ICIAR AVILES-OLMOS, Benchetrit, E., Benoit, C., Bergareche-Yarza, A., Cervantes-Arriaga, A., Chade, A., Cormier, F., Datieva, V., Gallagher, D. A., Garretto, N., Gdovinova, Z., Gerschanik, O., Grofik, M., Han, V., Huang, J., Kadastik-Eerme, L., Kurtis, M. M., Mangone, G., Martinez-Castrillo, J. C., Mendoza-Rodriguez, A., Minar, M., Moore, H. P., Muldmaa, M., Mueller, C., Pinter, B., Poewe, W., Rallmann, K., Reiter, E., Rodriguez-Blazquez, C., Singer, C., Tilley, B. C., Valkovic, P., Goetz, C. G., and Stebbins, G. T.
18. Differences in MDS-UPDRS scores based on Hoehn and Yahr stage and disease duration: Results of a large international multicenter study of 3206 patients (the QUALPD study)
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Skorvanek, M., Martinez-Martin, P., Kovacs, N., Zezula, I., Rodriguez-Violante, M., Corvol, J. -C, Taba, P., Seppi, K., Levin, O., Schrag, A., Foltynie, T., Alvarez-Sanchez, M., Arakaki, T., Aschermann, Z., Aviles-Olmos, I., Benchetrit, E., Benoit, C., Bergareche-Yarza, A., Cervantes-Arriaga, A., Chade, A., Cormier, F., Datieva, V., Gallagher, D. A., Garretto, N., Gdovinova, Z., Gershanik, O., Grofik, M., Han, V., Huang, J., Kadastik-Eerme, L., Kurtis, M. M., Mangone, G., Juan Carlos Martinez Castrillo, Mendoza-Rodriguez, A., Minar, M., Moore, H. P., Muldmaa, M., Mueller, C., Pinter, B., Poewe, W., Rallmann, K., Reiter, E., Rodriguez-Blazquez, C., Singer, C., Tilley, B. C., Valkovic, P., Goetz, C. G., and Stebbins, G. T.
19. Nutrition and physical activity programs for obesity treatment (PRONAF study): methodological approach of the project
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Zapico Augusto G, Benito Pedro J, González-Gross Marcela, Peinado Ana B, Morencos Esther, Romero Blanca, Rojo-Tirado Miguel A, Cupeiro Rocio, Szendrei Barbara, Butragueño Javier, Bermejo Maite, Alvarez-Sánchez María, García-Fuentes Miguel, Gómez-Candela Carmen, Bermejo Laura M, Fernandez-Fernandez Ceila, and Calderón Francisco J
- Subjects
Overweight ,Obesity ,Caloric restriction ,Exercise ,Weight loss ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background At present, scientific consensus exists on the multifactorial etiopatogenia of obesity. Both professionals and researchers agree that treatment must also have a multifactorial approach, including diet, physical activity, pharmacology and/or surgical treatment. These two last ones should be reserved for those cases of morbid obesities or in case of failure of the previous ones. The aim of the PRONAF study is to determine what type of exercise combined with caloric restriction is the most appropriate to be included in overweigth and obesity intervention programs, and the aim of this paper is to describe the design and the evaluation methods used to carry out the PRONAF study. Methods/design One-hundred nineteen overweight (46 males) and 120 obese (61 males) subjects aged 18–50 years were randomly assigned to a strength training group, an endurance training group, a combined strength + endurance training group or a diet and physical activity recommendations group. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure estimated by accelerometry). 29–34% of the total energy intake came from fat, 14–20% from protein, and 50–55% from carbohydrates. The mayor outcome variables assesed were, biochemical and inflamatory markers, body composition, energy balance, physical fitness, nutritional habits, genetic profile and quality of life. 180 (75.3%) subjects finished the study, with a dropout rate of 24.7%. Dropout reasons included: personal reasons 17 (28.8%), low adherence to exercise 3 (5.1%), low adherence to diet 6 (10.2%), job change 6 (10.2%), and lost interest 27 (45.8%). Discussion Feasibility of the study has been proven, with a low dropout rate which corresponds to the estimated sample size. Transfer of knowledge is foreseen as a spin-off, in order that overweight and obese subjects can benefit from the results. The aim is to transfer it to sports centres. Effectiveness on individual health-related parameter in order to determine the most effective training programme will be analysed in forthcoming publications. Trial registration ClinicalTrials.gov NCT01116856
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- 2012
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20. Recuperacion de las agudizaciones asmaticas en mujeres. Influencia de la edad y años de evolucion de la enfermedad
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Alvarez Sanchez, M<ce:sup loc='post">a</ce:sup>.T., Del Busto de Lorenzo, B., Diez Fernandez, L.F., Menendez del Campo, J.L., Roman Rojo, A., and Fernandez Rego, G.
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- 1983
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21. Evolucion clinico-radiologica de las neumonias por anaerobios
- Author
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Alvarez Sanchez, M.<ce:sup loc='post">a</ce:sup> T., Arias Alba, E., Ortega Alvarez, M., Alcazar Serrano, J.L., Gaspar Diego, E., Cabezudo Hernandez, M., Mendez Lanza, A., Muñoz Martinez, J., Sala Felis, J., and Mosquera Pestaña., J.
- Published
- 1982
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22. CHAPTER 16 - EUS in Bile Duct, Gallbladder, and Ampullary Lesions
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Napoléon, Bertrand, Alvarez-Sánchez, M. Victoria, Markoglou, Costas, and Lefort, Christine
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23. Contributors
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Alvarez-Sánchez, M. Victoria, Al-Haddad, Mohammad, Annema, Jouke T., Brugge, William R., DeWitt, John, Eloubeidi, Mohamad A., Faigel, Douglas O., Halligan, Steve, Harewood, Gavin C., Hwang, Joo Ha, Jhala, Darshana, Jhala, Nirag, Kim, Eun Young (Ann), Kimmey, Michael B., Lefort, Christine, Lennon, Anne Marie, Levy, Michael J., Markoglou, Costas, Meenan, John, Murad, Faris, Napoléon, Bertrand, Paquin, Sarto C., Penman, Ian D., Peter, Shajan, Rabe, Klaus F., Romagnuolo, Joseph, Rösch, Thomas, Sahai, Anand V., Sanders, Michael K., Savides, Thomas J., Seifert, Hans, Topazian, Mark, and Vu, Charles
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24. A Single 60.000 IU Dose of Erythropoietin Does Not Improve Short-Term Aerobic Exercise Performance in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.
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Haider T, Diaz V, Albert J, Alvarez-Sanchez M, Thiersch M, Maggiorini M, Hilty MP, Spengler CM, and Gassmann M
- Abstract
Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity. Twenty-nine healthy subjects (14 males/15 females; age: 25 ± 3 years) were included in a randomized, double-blind, placebo-controlled crossover study to assess peak work load and cardiopulmonary variables during submaximal and maximal cycling tests following a single dose of 60.000 IU of recombinant erythropoietin (EPO) or placebo (PLA). Submaximal exercise at 40%/60% of peak work load revealed no main effect of EPO on oxygen uptake (27.9 ± 8.7 ml min
-1 ⋅kg-1 / 37.1 ± 13.2 ml min-1 ⋅kg-1 ) versus PLA (25.2 ± 3.7 ml min-1 ⋅kg-1 / 33.1 ± 5.3 ml min-1 ⋅kg-1 ) condition ( p = 0.447/ p = 0.756). During maximal exercise peak work load (PLA: 3.5 ± 0.6 W⋅kg-1 vs. EPO: 3.5 ± 0.6 W kg-1 , p = 0.892) and peak oxygen uptake (PLA: 45.1 ± 10.4 ml⋅min-1 kg-1 vs. EPO: 46.1 ± 14.2 ml⋅min-1 kg-1 , p = 0.344) reached comparable values in the two treatment conditions. Other cardiopulmonary variables (ventilation, cardiac output, heart rate) also reached similar levels in the two treatment conditions. An interaction effect was found between treatment condition and sex resulting in higher peak oxygen consumption ( p = 0.048) and ventilation ( p = 0.044) in EPO-treated males. In conclusion, in a carefully conducted study using placebo-controlled design the present data failed to support the hypothesis that a single high dose of EPO has a measurable impact on work capacity in healthy subjects., (Copyright © 2020 Haider, Diaz, Albert, Alvarez-Sanchez, Thiersch, Maggiorini, Hilty, Spengler and Gassmann.)- Published
- 2020
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25. Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients.
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Skorvanek M, Martinez-Martin P, Kovacs N, Zezula I, Rodriguez-Violante M, Corvol JC, Taba P, Seppi K, Levin O, Schrag A, Aviles-Olmos I, Alvarez-Sanchez M, Arakaki T, Aschermann Z, Benchetrit E, Benoit C, Bergareche-Yarza A, Cervantes-Arriaga A, Chade A, Cormier F, Datieva V, Gallagher DA, Garretto N, Gdovinova Z, Gershanik O, Grofik M, Han V, Kadastik-Eerme L, Kurtis MM, Mangone G, Martinez-Castrillo JC, Mendoza-Rodriguez A, Minar M, Moore HP, Muldmaa M, Mueller C, Pinter B, Poewe W, Rallmann K, Reiter E, Rodriguez-Blazquez C, Singer C, Valkovic P, Goetz CG, and Stebbins GT
- Subjects
- Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Regression Analysis, Parkinson Disease diagnosis, Psychiatric Status Rating Scales, Quality of Life, Severity of Illness Index
- Abstract
Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients., Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items., Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue., Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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26. Differences in MDS-UPDRS Scores Based on Hoehn and Yahr Stage and Disease Duration.
- Author
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Skorvanek M, Martinez-Martin P, Kovacs N, Rodriguez-Violante M, Corvol JC, Taba P, Seppi K, Levin O, Schrag A, Foltynie T, Alvarez-Sanchez M, Arakaki T, Aschermann Z, Aviles-Olmos I, Benchetrit E, Benoit C, Bergareche-Yarza A, Cervantes-Arriaga A, Chade A, Cormier F, Datieva V, Gallagher DA, Garretto N, Gdovinova Z, Gershanik O, Grofik M, Han V, Huang J, Kadastik-Eerme L, Kurtis MM, Mangone G, Martinez-Castrillo JC, Mendoza-Rodriguez A, Minar M, Moore HP, Muldmaa M, Mueller C, Pinter B, Poewe W, Rallmann K, Reiter E, Rodriguez-Blazquez C, Singer C, Tilley BC, Valkovic P, Goetz CG, and Stebbins GT
- Abstract
Background: The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed tool to assess Parkinson's disease (PD). Changes in scores on the scale over the course of PD, including increasing disease duration and Hoehn and Yahr (HY) stages, have not been described. The objectives of this study were to analyze MDS-UPDRS scores on Parts I through IV and their differences based on HY stage and disease duration in a large cohort of patients with PD., Methods: For this cross-sectional study, demographic data and MDS-UPDRS scores were collected, including HY stage. Subscores on MDS-UPDRS Parts I through IV were analyzed using 1-way analyses of variance for each HY stage and in 5-year increments of disease duration. Part III (motor assessment) scores were analyzed separately for on and off states., Results: The mean age of the 3206 patients was 65.8 ± 10.6 years, 53.3% were men, the mean disease duration was 11.5 ± 4.6 years, and the median HY stage was 2 (range, 0-5); 2156 patients were examined in an on state and 987 were examined in an off state. Scores for all MDS-UPDRS parts increased significantly through HY stages 1 through 5, with an average increase of 3.8, 7.7, 14.6, and 2.0 points consecutively for parts I through IV, respectively. For the 5-year increments of disease duration, MDS-UPDRS subscores increased by an average of 1.6, 3.3, 4.2, and 1.4 points consecutively for parts I through IV, respectively. This increase was significant only during the first 15 years of disease for all 4 parts, including part III scores evaluated in both on and off states., Conclusions: MDS-UPDRS scores for all 4 parts increase significantly with every HY stage and also with 5-year increments of disease duration in the first 15 years of the disease.
- Published
- 2017
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27. The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease.
- Author
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Rodriguez-Blazquez C, Rojo-Abuin JM, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martinez-Castrillo JC, Mendoza-Rodriguez A, Moore HP, Rodriguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, Goetz CG, and Martinez-Martin P
- Subjects
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Disease Progression, Female, Health Status, Humans, Linear Models, Logistic Models, Male, Middle Aged, Parkinson Disease diagnosis, Predictive Value of Tests, Psychomotor Performance physiology, Quality of Life, Reproducibility of Results, Socioeconomic Factors, Surveys and Questionnaires, Activities of Daily Living, Disability Evaluation, Movement physiology, Parkinson Disease physiopathology
- Abstract
Objective: To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure., Methods: International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated., Results: MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and -0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p < 0.001). Cut-off values for the M-EDL were: 0-2 points, no disability; 3-16, mild; 17-31, moderate; and 32 points or more, severe. Linear regression analysis identified the MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59%)., Conclusions: MDS-UPDRS M-EDL proved to be useful for assessing disability in PD., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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28. Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
- Author
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Martinez-Martin P, Rodriguez-Blazquez C, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martinez-Castrillo JC, Mendoza-Rodriguez A, Moore HP, Rodriguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, and Goetz CG
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Female, Humans, International Cooperation, Male, Middle Aged, Observation, Reproducibility of Results, Retrospective Studies, Disability Evaluation, Neurologic Examination standards, Parkinson Disease diagnosis, Severity of Illness Index, Societies, Medical standards
- Abstract
The Movement Disorder Society-UPDRS (MDS-UPDRS) was published in 2008, showing satisfactory clinimetric results and has been proposed as the official benchmark scale for Parkinson's disease. The present study, based on the official MDS-UPDRS Spanish version, performed the first independent testing of the scale and adds information on its clinimetric properties. The cross-culturally adapted MDS-UPDRS Spanish version showed a comparative fit index ≥ 0.90 for each part (I-IV) relative to the English-language version and was accepted as the Official MDS-UPDRS Spanish version. Data from this scale, applied with other assessments to Spanish-speaking Parkinson's disease patients in five countries, were analyzed for an independent and complementary clinimetric evaluation. In total, 435 patients were included. Missing data were negligible and moderate floor effect (30 %) was found for Part IV. Cronbach's α index ranged between 0.79 and 0.93 and only five items did not reach the 0.30 threshold value of item-total correlation. Test-retest reliability was adequate with only two sub-scores of the item 3.17, Rest tremor amplitude, reaching κ values lower than 0.60. The intraclass correlation coefficient was higher than 0.85 for the total score of each part. Correlation of the MDS-UPDRS parts with other measures for related constructs was high (≥ 0.60) and the standard error of measurement lower than one-third baseline standard deviation for all subscales. Results confirm those of the original study and add information on scale reliability, construct validity, and precision. The MDS-UPDRS Spanish version shows satisfactory clinimetric characteristics.
- Published
- 2013
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29. Presyndromic phase: proposal for a new term for an emerging concept.
- Author
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Alvarez-Sanchez M and Alvarez-Sanchez M
- Subjects
- Humans, Parkinson Disease diagnosis
- Published
- 2012
- Full Text
- View/download PDF
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