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Your search keyword '"Alvarez‐Baron, Elena"' showing total 14 results
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14 results on '"Alvarez‐Baron, Elena"'

2. Value contribution of cenobamate for the treatment of Focal-Onset Seizures (FOS) in patients with drug-resistant epilepsy (DRE) in Spain through reflective Multi-Criteria Decision Analysis (MCDA)

Author

Falip, Mercè, López González, Francisco Javier, Martín-Herranz, Isabel, Merino-Bohórquez, Vicente, Montoya, Javier, Rey Gómez-Serranillos, Isabel, Rodriguez Uranga, Juan Jesús, Ruiz, Elías, Sancho-López, Aranzazu, Trillo Mata, Jose Luis, Antoni Vallès, Joan, Álvarez-Barón, Elena, Sabaniego, Joel, Subías-Labazuy, Silvia, and Gil, Alicia

Published
2023
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14. RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization.

Author

Alvarez-Baron, Elena, Michel, Katrin, Mittelstaedt, Tobias, Opitz, Thoralf, Schmitz, Frank, Beck, Heinz, Dietrich, Dirk, Becker, Albert J., and Schoch, Susanne

Subjects
*NEURONS, *INTERMOLECULAR interactions, *DENDRITES, *CELL culture, *SYNAPTIC vesicles, *EXOCYTOSIS
Abstract

The large isoforms of the Rab3 interacting molecule (RIM) family, RIM 1 α/γ and RIM2α/γ, have been shown to be centrally involved in mediating presynaptic active zone function. The RIM protein family contains two additional small isoforms, RIM3γ and RIM4γ, which are composed only of the RIM-specific C-terminal C2B domain and varying N-terminal sequences and whose function remains to be elucidated. Here, we report that both, RIM3γ and RIM4γ, play an essential role for the development of neuronal arborization and of dendritic spines independent of synaptic function. γ-RIM knock-down in rat primary neuronal cultures and in vivo resulted in a drastic reduction in the complexity of neuronal arborization, affecting both axonal and dendritic outgrowth, independent of the time point of γ-RIM downregulation during dendrite development. Rescue experiments revealed that the phenotype is caused by a function common to both γ-RIMs. These findings indicate that γ-RIMs are involved in cell biological functions distinct from the regulation of synaptic vesicle exocytosis and play a role in the molecular mechanisms controlling the establishment of dendritic complexity and axonal outgrowth. [ABSTRACT FROM AUTHOR]

Published
2013
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