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1. Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study

Author

Alvarez, Marifé, Andersen, Peter, Angeli, Paolo, Ardèvol, Alba, Arslanow, Anita, Beggiato, Luca, Ben Abdesselam, Zahia, Bennett, Lucy, Boutouria, Bajiha, Brocca, Alessandra, Broquetas, M. Teresa, Caballeria, Llorenç, Calvino, Valeria, Camacho, Judith, Capdevila, Aura, Carol, Marta, Castera, Laurent, Cervera, Marta, Cucchietti, Fernando, de Fuentes, Anna, de Knegt, Rob, de Koning, Harry J, Detlefsen, Sonke, Diaz, Alba, Diéguez Bande, José, Esnault, Vanessa, Fabrellas, Núria, Falcó, Josep Lluis, Fernández, Rosa, Fournier, Céline, Fuentes, Matilde, Galle, Peter, García, Edgar, García-Retortillo, Montserrat, Garrido, Esther, Ginès, Pere, Gordillo Medina, Rosa, Gratacós-Ginès, Jordi, Graupera, Isabel, Grgurevic, Ivica, Guha, Indra Neil, Guix, Eva, Hansen, Johanne Kragh, Harris, Rebecca, Hernández Boluda, Elena, Hernández-Ibañez, Rosario, Hoyo, Jordi, Ikram, Arfan, Incicco, Simone, Israelsen, Mads, Juan, Marta, Juanola, Adrià, Kaiser, Ralf, Kamath, Patrick S, Karlsen, Tom H, Kjærgaard, Maria, Korenjak, Marko, Krag, Aleksander, Krawczyk, Marcin, Laboulaye, Philippe, Lambert, Irina, Lammert, Frank, Langkjær Sørensen, Simon, Laserna-Jiménez, Cristina, Lazaro Pi, Sonia, Ledain, Elsa, Levy, Vincent, Lindvig, Katrine Prier, Llorca, Anne, Londoño, Vanessa, Loyer, Guirec, Ma, Ann T., Madir, Anita, Manns, Michael, Marshall, Denise, Martí, M. Lluïsa, Martínez, Sara, Martínez Sala, Ricard, Masa-Font, Roser, Møller Jensen, Jane, Morillas, Rosa M, Muñoz, Laura, Nadal, Ruth, Napoleone, Laura, Navarrete, JM, Newsome, Phillip N, Nielsen, Vibeke, Pérez, Martina, Pericás-Pulido, Juan Manuel, Piano, Salvatore, Pich, Judit, Pose, Elisa, Presas Escobet, Judit, Reichert, Matthias, Riba, Carlota, Roulot, Dominique, Rubio, Ana Belén, Sánchez-Morata, Maria, Schattenberg, Jörn, Serra-Burriel, Miquel, Serra-Burriel, Feliu, Skovborg Just, Louise, Sonneveld, Milan, Soria, Anna, Stern, Christiane, Such, Patricia, Thiele, Maja, Tonon, Marta, Toran, Pere, Torrejón, Antoni, Tsochatzis, Emmanuel A, van Kleef, Laurens, van Wijngaarden, Paulien, Velázquez, Vanessa, Viu, Ana, Weber, Susanne Nicole, Wildsmith, Tracey, Pera, Guillem, Reichert, Mathias, Pericàs, Juan M, Schattenberg, Jörn M, Tsochatztis, Emmanuel A, Garcia-Retortillo, Montserrat, Hernández, Rosario, Expósito, Carmen, Martínez, Alba, Detlefsen, Sönke, Martini, Andrea, Ma, Ann T, Pich, Judith, Bonfill, Eva, Navarrete, J M, Hernáez, Rubén, Allen, Alina, de Knegt, Robert J, and Wong, Vincent Wai-Sun

Published
2023
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2. Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study

Author

Serra-Burriel, Miquel, primary, Juanola, Adrià, additional, Serra-Burriel, Feliu, additional, Thiele, Maja, additional, Graupera, Isabel, additional, Pose, Elisa, additional, Pera, Guillem, additional, Grgurevic, Ivica, additional, Caballeria, Llorenç, additional, Piano, Salvatore, additional, van Kleef, Laurens, additional, Reichert, Mathias, additional, Roulot, Dominique, additional, Pericàs, Juan M, additional, Schattenberg, Jörn M, additional, Tsochatztis, Emmanuel A, additional, Guha, Indra Neil, additional, Garcia-Retortillo, Montserrat, additional, Hernández, Rosario, additional, Hoyo, Jordi, additional, Fuentes, Matilde, additional, Expósito, Carmen, additional, Martínez, Alba, additional, Such, Patricia, additional, Madir, Anita, additional, Detlefsen, Sönke, additional, Tonon, Marta, additional, Martini, Andrea, additional, Ma, Ann T, additional, Pich, Judith, additional, Bonfill, Eva, additional, Juan, Marta, additional, Soria, Anna, additional, Carol, Marta, additional, Gratacós-Ginès, Jordi, additional, Morillas, Rosa M, additional, Toran, Pere, additional, Navarrete, J M, additional, Torrejón, Antoni, additional, Fournier, Céline, additional, Llorca, Anne, additional, Arslanow, Anita, additional, de Koning, Harry J, additional, Cucchietti, Fernando, additional, Manns, Michael, additional, Newsome, Phillip N, additional, Hernáez, Rubén, additional, Allen, Alina, additional, Angeli, Paolo, additional, de Knegt, Robert J, additional, Karlsen, Tom H, additional, Galle, Peter, additional, Wong, Vincent Wai-Sun, additional, Fabrellas, Núria, additional, Castera, Laurent, additional, Krag, Aleksander, additional, Lammert, Frank, additional, Kamath, Patrick S, additional, Ginès, Pere, additional, Alvarez, Marifé, additional, Andersen, Peter, additional, Ardèvol, Alba, additional, Beggiato, Luca, additional, Ben Abdesselam, Zahia, additional, Bennett, Lucy, additional, Boutouria, Bajiha, additional, Brocca, Alessandra, additional, Broquetas, M. Teresa, additional, Calvino, Valeria, additional, Camacho, Judith, additional, Capdevila, Aura, additional, Cervera, Marta, additional, de Fuentes, Anna, additional, de Knegt, Rob, additional, Detlefsen, Sonke, additional, Diaz, Alba, additional, Diéguez Bande, José, additional, Esnault, Vanessa, additional, Falcó, Josep Lluis, additional, Fernández, Rosa, additional, García, Edgar, additional, García-Retortillo, Montserrat, additional, Garrido, Esther, additional, Gordillo Medina, Rosa, additional, Guix, Eva, additional, Hansen, Johanne Kragh, additional, Harris, Rebecca, additional, Hernández Boluda, Elena, additional, Hernández-Ibañez, Rosario, additional, Ikram, Arfan, additional, Incicco, Simone, additional, Israelsen, Mads, additional, Kaiser, Ralf, additional, Kjærgaard, Maria, additional, Korenjak, Marko, additional, Krawczyk, Marcin, additional, Laboulaye, Philippe, additional, Lambert, Irina, additional, Langkjær Sørensen, Simon, additional, Laserna-Jiménez, Cristina, additional, Lazaro Pi, Sonia, additional, Ledain, Elsa, additional, Levy, Vincent, additional, Lindvig, Katrine Prier, additional, Londoño, Vanessa, additional, Loyer, Guirec, additional, Ma, Ann T., additional, Marshall, Denise, additional, Martí, M. Lluïsa, additional, Martínez, Sara, additional, Martínez Sala, Ricard, additional, Masa-Font, Roser, additional, Møller Jensen, Jane, additional, Muñoz, Laura, additional, Nadal, Ruth, additional, Napoleone, Laura, additional, Navarrete, JM, additional, Nielsen, Vibeke, additional, Pérez, Martina, additional, Pericás-Pulido, Juan Manuel, additional, Pich, Judit, additional, Presas Escobet, Judit, additional, Reichert, Matthias, additional, Riba, Carlota, additional, Rubio, Ana Belén, additional, Sánchez-Morata, Maria, additional, Schattenberg, Jörn, additional, Serra-Burriel, Miquel, additional, Skovborg Just, Louise, additional, Sonneveld, Milan, additional, Stern, Christiane, additional, Tsochatzis, Emmanuel A, additional, van Wijngaarden, Paulien, additional, Velázquez, Vanessa, additional, Viu, Ana, additional, Weber, Susanne Nicole, additional, and Wildsmith, Tracey, additional

Published
2023
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3. LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries

Author

Graupera, Isabel, Thiele, Maja, Ma, Ann T., Serra-Burriel, Miquel, Pich, Judit, Fabrellas, Núria, Caballeria, Llorenç, de Knegt, Robert J., Grgurevic, Ivica, Reichert, Mathias, Roulot, Dominique, Schattenberg, Jörn M., Pericas, Juan M., Angeli, Paolo, Tsochatzis, Emmanuel A., Guha, Indra Neil, Garcia-Retortillo, Montserrat, Morillas, Rosa M., Hernández, Rosario, Hoyo, Jordi, Fuentes, Matilde, Madir, Anita, Juanola, Adrià, Soria, Anna, Juan, Marta, Carol, Marta, Diaz, Alba, Detlefsen, Sönke, Toran, Pere, Fournier, Céline, Llorca, Anne, Newsome, Phillip N., Manns, Michael, de Koning, Harry J., Serra- Burriel, Feliu, Cucchietti, Fernando, Arslanow, Anita, Korenjak, Marko, van Kleef, Laurens, Falcó, Josep Lluis, Kamath, Patrick S., Karlsen, Tom H., Castera, Laurent, Lammert, Frank, Krag, Aleksander, Ginès, Pere, Alvarez, Marifé, Andersen, Peter, Ardèvol, Alba, Beggiato, Luca, Abdesselam, Zahia Ben, Bennett, Lucy, Boutouria, Bajiha, Brocca, Alessandra, Broquetas, M. Teresa, Caballeria, Llorenc, Calvino, Valeria, Camacho, Judith, Capdevila, Aura, Cervera, Marta, de Fuentes, Anna, de Knegt, Rob, Detlefsen, Sonke, Bande, José Diéguez, Esnault, Vanessa, Falco, Josep lluis, Fernández, Rosa, Fournier, Celine, Galle, Peter, García, Edgar, García-Retortillo, Montserrat, Garrido, Esther, Medina, Rosa Gordillo, Gratacós- Gines, Jordi, Guix, Eva, Harris, Rebecca, Boluda, Elena Hernández, Hernández-Ibañez, Rosario, Ikram, Arfan, Incicco, Simone, Israelsen, Mads, Juanola, Adria, Kaiser, Ralf, Kjærgaard, Maria, Hansen, Johanne Kragh, Krawczyk, Marcin, Lambert, Irina, Laboulaye, Philippe, Sørensen, Simon Langkjær, Laserna- Jiménez, Cristina, Pi, Sonia Lazaro, Ledain, Elsa, Levy, Vincent, Londoño, Vanessa, Loyer, Guirec, Marshall, Denise, Martí, M. Lluïsa, Martínez, Sara, Sala, Ricard Martínez, Font, Roser Masa, Jensen, Jane Møller, Muñoz, Laura, Nadal, Ruth, Napoleone, Laura, Navarrete, J. M., Nielsen, Vibeke, Pérez, Martina, Pulido, Juan Manuel Pericas, Piano, Salvatore, Escobet, Judit Presas, Pose, Elisa, Lindvig, Katrine Prier, Reichert, Matthias, Riba, Carlota, Rubio, Ana Belén, Sánchez- Morata, Maria, Schattenberg, Jörn, Just, Louise Skovborg, Sonneveld, Milan, Stern, Christiane, Such, Patricia, Torrejón, Antoni, Tonon, Marta, van Wijngaarden, Paulien, Velázquez, Vanessa, Viu, Ana, Weber, Susanne Nicole, Wildsmith, Tracey, for the LiverScreen Consortium investigators, Gastroenterology & Hepatology, Public Health, and Epidemiology

Subjects
Liver Cirrhosis, Cirrosi hepàtica, Biopsy, Chronic liver disease, Liver fibrosis, Public Health, Environmental and Occupational Health, NASH, Cirrhosis, NAFLD, Screening, Vibration-controlled transient elastography, Europe, Humans, Elasticity Imaging Techniques, Mass Screening, Diagnòstic per la imatge, SDG 3 - Good Health and Well-being, Hepatic cirrhosis, Diagnostic imaging, Biòpsia
Abstract

Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. Trial registration This study is registered on Clinicaltrials.gov (NCT03789825).

Published
2022

4. WED-284-YI The Fatty Liver Index (FLI) is more accurate than FIB-4 for detection of advanced liver fibrosis in patients with type-2 Diabetes Mellitus (T2DM) in Primary Care

Author

Nadal, Ruth, Juanola, Adrià, Hoyo, Jordi, Martinez, Sara, Carvelli, Ana, Soria, Anna, Sanz-Rodríguez, Maria, Carol, Marta, Perez-Guasch, Martina, Cervera, Marta, Garcia, Ana Belen Rubio, Pellon, Miriam, Alvarez, Marife, Lopez, Marina Gigante, Herreros, Yolanda, Pozo, Cristina, Riba, Carlota, Moreta, Maria Jose, Gratacós-Ginès, Jordi, Pose, Elisa, Graupera, Isabel, Ginès, Pere, and Fabrellas, Nuria

Published
2024
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5. SAT-415 - Patients with risk factors for liver diseases associated with hepatic steatosis constitute the target population for liver fibrosis assessment in primary care

Author

Hernández, Rosario, Hoyo, Jordi, Carol, Marta, Nadal, Ruth, Juanola, Adria, Soria, Anna, Rubio Garcia, Ana Belen, Cervera, Marta, Perez, Martina, Fuentes, Matilde, Pera, Guillem, Martinez, Sara, Chacon, Carla, Sanchez, Maria, Capdevila, Aura, Alvarez, Marife, Gratacos, Jordi, Torán, Pere, Graupera, Isabel, Pose, Elisa, Martínez-Escudé, Alba, Ginès, Pere, Caballeria, Llorenç, and Fabrellas, Núria

Published
2023
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