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12 results on '"Alvarez, Luis I."'

11. Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice

Author

Pensel, Patricia E., primary, Ullio Gamboa, Gabriela, additional, Fabbri, Julia, additional, Ceballos, Laura, additional, Sanchez Bruni, Sergio, additional, Alvarez, Luis I., additional, Allemandi, Daniel, additional, Benoit, Jean Pierre, additional, Palma, Santiago D., additional, and Elissondo, María C., additional

Published
2015
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12. Testing Albendazole Resistance in Fasciola hepatica.

Author

Alvarez LI, Valladares MM, Canton C, Lanusse CE, and Ceballos L

Subjects
Animals, Cattle, Eggs parasitology, Fascioliasis parasitology, Feces parasitology, Sheep parasitology, Sheep Diseases parasitology, Albendazole pharmacology, Drug Resistance drug effects, Fasciola hepatica drug effects, Fascioliasis drug therapy, Sheep Diseases drug therapy
Abstract

The egg development test is a useful in vitro tool to detect albendazole (ABZ) resistance in Fasciola hepatica. ABZ is the only flukicidal compound with ovicidal activity. The described test is based on the ABZ capacity to affect parasite egg development and hatching in susceptible parasites, while this effect is lost in ABZ-resistant liver fluke isolates. Among many advantages, it is noted that the diagnostic test can be performed on eggs isolated from fecal samples (sheep and cattle), avoiding the sacrifice of animals necessary in controlled efficacy trials. The egg development test described here is a simple, inexpensive, and accessible method, previously employed for diagnosis of ABZ resistance in F. hepatica.

Published
2020
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