1. t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
- Author
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Vizmanos-Pérez, J.L. (José Luis), Larrayoz, M.J. (María J.), Lahortiga, I. (Idoya), Floristan, F. (Filomena), Alvarez, C. (Carmen), Odero, M.D. (Maria Dolores), Novo-Villaverde, F. J. (Francisco Javier), and Calasanz-Abinzano, M.J. (Maria Jose)
- Subjects
Nuclear Proteins/genetics ,congenital, hereditary, and neonatal diseases and abnormalities ,hemic and lymphatic diseases ,Chromosomes, Human, Pair 10/genetics ,Leukemia, Monocytic, Acute/genetics ,Oncogene Proteins, Fusion/genetics ,Saccharomyces cerevisiae Proteins/genetics ,Chromosomes, Human, Pair 16/genetics ,neoplasms ,Trans-Activators/genetics - Abstract
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML.
- Published
- 2003