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2. Study of the Optimization of a Dental Articulator System

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Guzmán-Mercado, Verónica, Beltrán-Fernández, Juan Alfonso, González-Rebattú y González, Mauricio, Alvarado-Alcántara, Erik Omar, Vázquez-Thierry, Karen Pamela, Alvarado-Moreno, Carolina, Moreno-Garibaldi, Pablo, Hermida-Ochoa, Juan Carlos, Öchsner, Andreas, Series Editor, da Silva, Lucas F. M., Series Editor, and Altenbach, Holm, Series Editor

Published
2024
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6. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

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Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, Patel, Chetna, Patel, Sunaina, Patel, Vitan, Patel, Deep, Patel, Harshad, Patil, Girish, Peter, Deepu, Prasad, Durga, Purohit, Vimlesh, Rabindrarajan, Ebenezer, Ranganathan, Lakshmiarasimhan, Rao, Tushara, Rao, Chakradhara, Rathod, Chirag, Raval, Devang, Ray, Avik, Reddy, Kamini, Rege, Sujata, Revathi, Ayyasamy, Roy, Dhara, Saigal, Saurabh, Sane, Suvarna, Sangale, Shashi, Seetharaman, Krishnamoorthy, Selvamuthu, Poongulali, Seshaiah, Kurada Venkata, Shadrach, Benhur, Shah, Jignesh, Shah, Sonal, Sharma, Swati, Sharma, Raman, Sharma, Shrikant, Singh, Krishna, Singh, Anil, Singh, Arjeet, Singhai, Abhishek, Soneja, Manish, Soni, Kapil Dev, Subhan, Thasneem banu, Subramaniam, Sudharshini, Sudarsanam, Thambu David, Sudarsi, Ravindra Kumar, Suleman, Dawood, Suthar, Nilay, Talati, Shriraj, Tambe, Murlidhar, Tejomurtula, Tilak, Tirupakuzhi Vijayaraghavan, Bharatkumar, Trikha, Anjan, Trivedi, Aarti, Udwadia, Zarir, Upadhyay, Kamlesh, Vasava, Ashwin, Vasudevan, Damodaran, Velayudham, Rajendran, Venkatasubramanian, Ramasubramanian, Verma, Mamta, Waghmare, Rakesh, Waikar, Anushka, Wig, Naveet, Afrilia, Annisa Rizky, Amin, Muhammad, Arlinda, Dona, Avrina, Rossa, Bang, Lois, Djaharuddin, Irawaty, Djojo, Aryan, Driyah, Sri Laning, Erastuti, Mila, Fajarwati, Tetra, Harsini, Harsini, Hartantri, Yovita, Herman, Deddy, Isbaniah, Fathiyah, Karyana, Muhammad, Kusuma, Indra, Mahmudji, Harli Amir, Medison, Irvan, Nugroho, Agung, Nurhayati, Nurhayati, Opitasari, Cicih, Pitoyo, Ceva Wicaksono, Pradana, Antonius Arditya, Raharjo, Sofyan Budi, Rahmaini, Ade, Risniati, Yenni, Riyanto, Bambang Sigit, Sajinadiyasa, I Gede Ketut, Sari, Flora Eka, Sitompul, Pompini Agustina, Soedarsono, Soedarsono, Somia, I Ketut Agus, Sugiri, Yani Jane, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Syarif, Armaji Kamaludi, Yulianto, Aris, Afsharian, Mandana, Akhavi Mirab, Atefehsadat, Amini, Fatemeh, Amini, Mahnaz, Ansarin, Khalil, Baba Mahmoodi, Farhang, Baghaei, Parvaneh, Barazandeh, Fateme, Bayani, Masomeh, Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt

Published
2022
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8. Manufacturing of a Human’s Hand Prosthesis with Electronic Movable Phalanges Based on a CT Image: An Amputation Case

Author

Beltrán-Fernández, Juan Alfonso, Hernández, Itzel Alejandrina Aguirre, Bantle-Chávez, Itzel, Alvarado-Moreno, Carolina, Hernández-Gómez, Luis Héctor, Moreno-Garibaldi, Pablo, Chipol, Nefi Pava, Ochoa, Juan Carlos Hermida, Lievano, Adolfo Lopez, Urriolagoitia-Calderón, Guillermo Manuel, Öchsner, Andreas, Series Editor, da Silva, Lucas F. M., Series Editor, and Altenbach, Holm, Series Editor

Published
2020
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10. Numerical and Experimental Analysis of a Personalized Prosthesis for a Patient with Unilateral Hip Osteoarthritis

Author

Beltrán-Fernández, Juan Alfonso, Ruiz-Muñoz, Omar Rolando, Hernández-Gómez, Luis Héctor, González-Rebattú y González, Alejandro, Bantle-Chávez, Itzel, Alvarado-Moreno, Carolina, Moreno-Garibaldi, Pablo, Chipol, Nefi Pava, Öchsner, Andreas, Series Editor, da Silva, Lucas F. M., Series Editor, and Altenbach, Holm, Series Editor

Published
2020
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13. Identification of genetic risk factors associated with ischaemic stroke in young Mexican patients

Author

M.C. Jiménez-González, D. Santiago-Germán, E.F. Castillo-Henkel, J.A. Alvarado-Moreno, J. Hernández-Juárez, A. Leaños-Miranda, A. Majluf-Cruz, and I. Isordia-Salas

Subjects
TAFI, PAI-1, GP IIb/IIIa, eNOS, 5,10 MTHFR, EVC., Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: Numerous polymorphisms in candidate genes coding for haemostatic system proteins have been proposed as risk factors for thrombosis. Methods: We performed a case-control study of consecutive ischaemic stroke survivors aged ≤45 years, treated at our neurology department from 2006 to 2014. Polymerase chain reaction–restriction fragment length polymorphism identified the following polymorphisms: Thr325Ile and Ala147Thr in TAFI, 4 G/5 G in PAI-1, PLA1/A2 in platelet glycoprotein IIb/IIIa, Glu298Asp in eNOS, and C677 T in 5,10-MTHFR. A multivariate logistic regression analysis was performed to evaluate the independent risk of stroke. Results: 204 cases and 204 age- and sex-matched controls were included in the study. Clinical and genetic variables associated with ischaemic stroke were hypertension (P = .03), tobacco use (P = .02), and the polymorphisms Glu298Asp (genotype: P = .001, allele frequency: P = .001) and C677 T (genotype: P = .01); the Ala147Thr, Thr325IIe, 4 G/5 G, and PLA1/A2 mutations were not associated with ischaemic stroke. The 298Asp (P = .03) and T (P = .01) alleles, hypertension (P = .03), tobacco use (P = .01) and family history of stroke (P = .04) were identified as independent risk factors. Conclusion: The polymorphisms Glu298Asp and C677T, affecting the eNOS and 5,10-MTHFR enzymes, respectively, and smoking, hypertension, and family history of stroke were associated with ischaemic stroke in young Mexican patients; this was not the case for the Thr325Ile, Ala147Thr, 4 G/5 G, and PLA1/A2 polymorphisms of the genes coding for fibrinolytic proteins and platelet receptors. Resumen: Introducción: Diversos polimorfismos en genes candidatos que codifican proteínas del sistema hemostático se han propuesto como factores de riesgo para el desarrollo de trombosis. Métodos: Casos y controles, sobrevivientes de enfermedad vascular cerebral (EVC) isquémico idiopático ≤ 45 años de edad del servicio de Neurología incluidos de manera consecutiva del 2006 al 2014. Por PCR-RFLP se identificaron los polimorfismos: Thr325Ile y Ala147Thr del gen de TAFI, 4 G/5 G del gen de PAI-1, PLA1/A2 del gen de la glicoproteína plaquetaria IIb/IIIa, Glu298Asp del gen de eNOS, y C677 T del gen de la 5,10 MTHFR. Se realizó un análisis multivariado de regresión logística para calcular el riesgo independiente de EVC. Resultados: 204 casos y 204 controles pareados por edad y sexo. Se asoció al polimorfismo Glu298Asp (genotipo p=0.001 y frecuencia alélica p=0.001), C677 T (genotipo p=0.01), hipertensión (p=0.03) y tabaquismo (p=0.02) con la presencia de EVC isquémico, no así para los polimorfismos Ala147Thr, Thr325IIe, 4 G/5 G, y PLA1/A2. Se identificó como factor de riesgo independiente al alelo 298Asp (p = 0.03), T (p = 0.01), hipertensión (p = 0.03), tabaquismo (p = 0.01) y AHFEAT (p = 0.04). Conclusiones: Los polimorfismos Glu298Asp y C677 T de los genes que codifican a la enzima eNOS y 5,10 MTHFR, tabaquismo, hipertensión y AHFEAT, se asociaron a la presencia de EVC isquémico en jóvenes mexicanos, no así el Thr325Ile, Ala147Thr, 4 G/5 G, PLA1/A2 en genes que codifican proteínas del sistema de fibrinólisis y receptores plaquetarios.

Published
2021
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14. Characterization of Scaffold Structures for the Development of Prostheses and Biocompatible Materials

Author

Hernández-Gómez, Luis Héctor, Beltrán-Fernández, Juan Alfonso, Ramírez-Jarquín, Marcelino, Bantle-Chávez, Itzel, Alvarado-Moreno, Carolina, González-Rebattú y González, Alejandro, González-Rebattú y González, Mauricio, Flores-Campos, Juan Alejandro, Moreno-Garibaldi, Pablo, Pava-Chipol, Nefi, Pérez-Montejo, Salatiel, Öchsner, Andreas, Series Editor, da Silva, Lucas F. M., Series Editor, and Altenbach, Holm, Series Editor

Published
2019
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15. Design and Characterization of a Mandibular Prosthesis Prototype by Hemimandibulectomy

Author

Beltrán-Fernández, Juan Alfonso, Picco-Díaz, Iliana, Bantle-Chávez, Itzel, Alvarado-Moreno, Carolina, Hernández-Gómez, Luis Héctor, Cuevas-Andrade, Juan Luis, González-Rebattú, Mauricio, López-Lievano, Adolfo, Flores-Campos, Juan Alejandro, Moreno-Garibaldi, Pablo, Öchsner, Andreas, Series Editor, da Silva, Lucas F. M., Series Editor, and Altenbach, Holm, Series Editor

Published
2019
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16. Sistema de Gestión Ambiental en el Distrito de Ventanilla

Author

José Luis Alvarado Moreno

Subjects
factores ambientales, índice de calidad ambiental, matriz de evaluación ambiental, sistema de gestión ambiental, Mining engineering. Metallurgy, TN1-997, Engineering (General). Civil engineering (General), TA1-2040, Geography (General), G1-922
Abstract

El Centro Poblado de Mi Perú en la actualidad cuenta con una población de 43,000 habitantes y posee una superficie total de 1.89 Km2. Para esta localidad, una solución de gestión ambiental municipal, es presentada, la cual está orientada a objetivos, y trabaja bajo el enfoque del desarrollo sostenible. La gestión ambiental municipal es considerada como una importante herramienta de gestión para el municipio, por ello es necesario comprender que es realmente y que beneficios se logran, así como también, reconocer la importancia de incorporar variables y factores ambientales en la gestión municipal. En esta investigación se priorizaron tres aspectos: 1) los diagnósticos Ambientales, para determinar el nivel de calidad ambiental en el Centro Poblado Mi Perú; 2) el marco conceptual y teórico de la Gestión Ambiental Municipal, que rodea la gestión ambiental municipal, sus diferentes instrumentos, el área de aplicación del estudio; 3) el Sistema de Gestión Ambiental propuesto, del cual se presenta su arquitectura, funcionamiento y características. Finalmente se presentan los resultados, conclusiones y recomendaciones obtenidas producto del estudio realizado.

Published
2019
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17. Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells

Author

Patricia Torres-Barrera, Dafne Moreno-Lorenzana, José Antonio Alvarado-Moreno, Elena García-Ruiz, Cesar Lagunas, Hector Mayani, and Antonieta Chávez-González

Subjects
Leukemic Stem Cells, CML, Microenvironment, Endothelial Cells, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Chronic Myeloid Leukemia (CML) originates in a leukemic stem cell that resides in the bone marrow microenvironment, where they coexist with cellular and non-cellular elements. The vascular microenvironment has been identified as an important element in CML development since an increase in the vascularization has been suggested to be related with poor prognosis; also, using murine models, it has been reported that bone marrow endothelium can regulate the quiescence and proliferation of leukemic stem and progenitor cells. This observation, however, has not been evaluated in primary human cells. In this report, we used a co-culture of primitive (progenitor and stem) CML cells with endothelial colony forming cells (ECFC) as an in vitro model to evaluate the effects of the vascular microenvironment in the leukemic hematopoiesis. Our results show that this interaction allows the in vitro maintenance of primitive CML cells through an inflammatory microenvironment able to regulate the proliferation of progenitor cells and the permanence in a quiescent state of leukemic stem cells.

Published
2022
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20. High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse

Author

Velázquez-Avila, Martha, Balandrán, Juan Carlos, Ramírez-Ramírez, Dalia, Velázquez-Avila, Mirella, Sandoval, Antonio, Felipe-López, Alfonso, Nava, Porfirio, Alvarado-Moreno, José Antonio, Dozal, David, Prieto-Chávez, Jessica L., Schaks, Matthias, Rottner, Klemens, Dorantes-Acosta, Elisa, López-Martínez, Briceida, Schnoor, Michael, and Pelayo, Rosana

Published
2019
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21. El caso del licenciamiento de una invención científica mexicana y su relación con el prestigio universitario: una lectura desde Bourdieu.

Author

FELIPE ALVARADO-MORENO

Subjects
Transferencia Tecnológica, Patentamiento, Licenciamiento, Propiedad Intelectual, Desarrollo Socioeconómico., Technology, Sociology (General), HM401-1281
Abstract

En México hay muy pocas universidades públicas que obtienen certificados de patente y muy pocas de ellas llegan al sector empresarial. El objetivo de este documento es describir y explicar el caso del licenciamiento de una patente académica, aplicando como marco teórico-conceptual la Teoría de Campos de Pierre Bourdieu. El análisis se centra en la diferenciación de perspectivas e intereses entre los actores involucrados: el inventor, la universidad licenciante y el empresario licenciatario. Al final, se reflexiona sobre el impacto social de las invenciones científicas (como la que aquí se presenta) cuando son colocadas en el mercado.

Published
2020

26. Manufacturing of a Human’s Hand Prosthesis with Electronic Movable Phalanges Based on a CT Image: An Amputation Case

Author

Beltrán-Fernández, Juan Alfonso, primary, Hernández, Itzel Alejandrina Aguirre, additional, Bantle-Chávez, Itzel, additional, Alvarado-Moreno, Carolina, additional, Hernández-Gómez, Luis Héctor, additional, Moreno-Garibaldi, Pablo, additional, Chipol, Nefi Pava, additional, Ochoa, Juan Carlos Hermida, additional, Lievano, Adolfo Lopez, additional, and Urriolagoitia-Calderón, Guillermo Manuel, additional

Published
2019
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27. Characterization of Scaffold Structures for the Development of Prostheses and Biocompatible Materials

Author

Hernández-Gómez, Luis Héctor, primary, Beltrán-Fernández, Juan Alfonso, additional, Ramírez-Jarquín, Marcelino, additional, Bantle-Chávez, Itzel, additional, Alvarado-Moreno, Carolina, additional, González-Rebattú y González, Alejandro, additional, González-Rebattú y González, Mauricio, additional, Flores-Campos, Juan Alejandro, additional, Moreno-Garibaldi, Pablo, additional, Pava-Chipol, Nefi, additional, and Pérez-Montejo, Salatiel, additional

Published
2018
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28. Design and Characterization of a Mandibular Prosthesis Prototype by Hemimandibulectomy

Author

Beltrán-Fernández, Juan Alfonso, primary, Picco-Díaz, Iliana, additional, Bantle-Chávez, Itzel, additional, Alvarado-Moreno, Carolina, additional, Hernández-Gómez, Luis Héctor, additional, Cuevas-Andrade, Juan Luis, additional, González-Rebattú, Mauricio, additional, López-Lievano, Adolfo, additional, Flores-Campos, Juan Alejandro, additional, and Moreno-Garibaldi, Pablo, additional

Published
2018
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30. Defect detection in textiles using special techniques fortexture analysis

Author

José David Alvarado Moreno

Subjects
análisis de textura, distancia de mahalanobis, defectos en textiles, matriz de co-ocurrencia, patrones locales binarios, filtrado de imágenes., Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract

This paper presents the use of spatial analysis techniques texture images for defects identification in textiles, where the application of pre-processing techniques is presented, and the analysis of texture local binary patterns and co-occurrence matrix to extract features to highlight differences and identify defects in textiles using classifier based on the Mahalanobis distance.

Published
2016
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31. El Papel de las Oficinas de Transferencia Tecnológica (OTT) en las Universidades: Una Perspectiva de la Última Década.

Author

Felipe Alvarado Moreno

Subjects
Oficinas de Transferencia de Tecnología, Universidad, Empresa, Innovación, Comercialización del Conocimiento., Technology, Technology (General), T1-995
Abstract

In the framework of a global economy based on knowledge, entrepreneurial universities implement new guiding axes to become generators of knowledge that trigger technological development. In this context, the creation of the Technology Transfer Offices (TTOs) in universities is a vital strategy for the scientific-governmental-business-social ecosystem to subsist with balance and grow simultaneously. In this document, the configuration, performance, and problems of these offices are analyzed, based on a general literature review of the last decade. Keywords: Technology Transfer Offices; University; Company; Innovation; Knowledge Comercialization. -------------------------------------------------------------------- En el marco de una economía mundial basada en el conocimiento, las universidades emprendedoras implementan nuevos ejes rectores para convertirse en generadoras de conocimiento que detone desarrollo tecnológico. En este contexto, la creación de Oficinas de Transferencia Tecnológica (OTT) en las universidades es una estrategia vital para que el ecosistema científico-gubernamental-empresarial-social subsista con equilibrio y crezca simultáneamente. En este documento, se analiza la configuración, el desempeño y las problemáticas de estas oficinas, a partir de una revisión general de literatura de la última década. Palabras Clave: Oficinas de Transferencia Tecnológica; Universidad; Empresa; Innovación; Comercialización del Conocimiento.

Published
2018
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33. Morphological and functional alterations in endothelial colony-forming cells from recovered COVID-19 patients

Author

José Antonio Alvarado-Moreno, Antonieta Chávez-González, Rodrigo Arreola-Diaz, Irma Isordia-Salas, Abraham Majluf-Cruz, Jorge Davila-Moreno, and Víctor Domínguez-Reyes

Subjects
Adult, Male, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Endothelial cells, Article, Young Adult, Recurrence, Medicine, Humans, Cells, Cultured, Cell Proliferation, Endothelial Progenitor Cells, Cell growth, business.industry, SARS-CoV-2, COVID-19, Thrombosis, Endothelial Colony-Forming Cells, Hematology, Venous Thromboembolism, Middle Aged, Virology, Endothelial cell dysfunction, Cytokines, Female, business, Reactive Oxygen Species
Abstract

Endothelial cells (ECs) are an important component of the blood coagulation system because it maintains blood fluid. Because in patients with venous thromboembolic disease (VTD) a thrombophilic condition is not found sometimes, we investigated if endothelial colony-forming cells (ECFCs) from these patients have biological and functional abnormalities.Human mononuclear cells (MNCs) were obtained from peripheral blood from patients with VTD and controls to obtain ECFCs. These cells were assayed for their immunophenotype and electron microscopy characteristics and their ability to form capillary-like structures and to produce pro-inflammatory and pro-angiogenic cytokines and reactive oxygen species (ROS).ECFCs appeared at 7 and 21 days of culture in VTD patients and controls, respectively. ECFCs increased 8-fold in patients and emerged 1 week earlier. No differences in the size of the colonies of ECFCs were found. Numbers and time of appearance of ECFCs was different between groups. ECFC-derived ECs (ECFC-ECs) of both groups expressed CD31, CD34, CD146, and CD-309 but none expressed CD45, CD14, or CD90. Interest CD34 was highly expressed in ECFC-ECs from patients. In both groups, ECFC-ECs showed similar capacity to form capillary-like structures but ECFC-ECs from patients had significant abnormalities in the mitochondrial membrane. We found a significant increase in ROS production in ECFC-ECs from patients. There were significant differences in cytokine profiles between VTD patients and controls.We found a dysfunctional state in ECFC from VTD patients resembling some characteristics of dysfunctional ECs. These findings may help to understand some pathophysiological aspects of VTD.

Published
2021

34. Reflexiones sobre los modelos tecnopedagógicos para la continuidad académica vía remota, implementados durante la suspensión de clases presenciales por situaciones de emergencia sanitaria.

Author

Alvarado Moreno, Katty Isabel, Ramírez-López, Martha, and Farías Coelho, Patrícia Margarida

Subjects
UNIVERSITIES & colleges, CONTENT analysis, COMPARATIVE studies, EXPERIMENTAL design
Abstract

Copyright of Veredas: Revista Interdisciplinar de Ciências Humanas is the property of Obras Sociais e Educacionais de Luz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

36. Reduced proliferation of endothelial colony-forming cells in unprovoked venous thromboembolic disease as a consequence of endothelial dysfunction.

Author

Rubicel Hernandez-Lopez, Antonieta Chavez-Gonzalez, Patricia Torres-Barrera, Dafne Moreno-Lorenzana, Norma Lopez-DiazGuerrero, David Santiago-German, Irma Isordia-Salas, David Smadja, Mervin C Yoder, Abraham Majluf-Cruz, and J Antonio Alvarado-Moreno

Subjects
Medicine, Science
Abstract

Venous thromboembolic disease (VTD) is a public health problem. We recently reported that endothelial colony-forming cells (ECFCs) derived from endothelial cells (EC) (ECFC-ECs) from patients with VTD have a dysfunctional state. For this study, we proposed that a dysfunctional status of these cells generates a reduction of its proliferative ability, which is also associated with senescence and reactive oxygen species (ROS).Human mononuclear cells (MNCs) were obtained from peripheral blood from 40 healthy human volunteers (controls) and 50 patients with VTD matched by age (20-50 years) and sex to obtain ECFCs. We assayed their proliferative ability with plasma of patients and controls and supernatants of cultures from ECFC-ECs, senescence-associated β-galactosidase (SA-β-gal), ROS, and expression of ephrin-B2/Eph-B4 receptor. Compared with cells from controls, cells from VTD patients showed an 8-fold increase of ECFCs that emerged 1 week earlier, reduced proliferation at long term (39%) and, in passages 4 and 10, a highly senescent rate (30±1.05% vs. 91.3±15.07%, respectively) with an increase of ROS and impaired expression of ephrin-B2/Eph-4 genes. Proliferation potential of cells from VTD patients was reduced in endothelial medium [1.4±0.22 doubling population (DP)], control plasma (1.18±0.31 DP), or plasma from VTD patients (1.65±0.27 DP).As compared with controls, ECFC-ECs from individuals with VTD have higher oxidative stress, proliferation stress, cellular senescence, and low proliferative potential. These findings suggest that patients with a history of VTD are ECFC-ECs dysfunctional that could be associated to permanent risk for new thrombotic events.

Published
2017
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38. Diversity and distribution of endophytic fungi in different tissues of Hevea brasiliensis native to the Brazilian Amazon forest

Author

Marisa Vieira de Queiroz, Tomás Gomes Reis Veloso, Olinto Liparini Pereira, Eduardo S. G. Mizubuti, Tiago S. de Leite, Braz Tavares da Hora Junior, Hanna Lorena Alvarado Moreno, Vanessa Nascimento Brito, Kaliane S. Araújo, and Janaina L. Alves

Subjects
0106 biological sciences, Trichocomaceae, 0303 health sciences, biology, Diaporthaceae, Hypocreaceae, Nectriaceae, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Agricultural and Biological Sciences (miscellaneous), Plant use of endophytic fungi in defense, 030308 mycology & parasitology, 03 medical and health sciences, Genus, Botany, Hevea brasiliensis, Ecology, Evolution, Behavior and Systematics, Hevea
Abstract

The genus Hevea is native to the Brazilian Amazon forest, and H. brasiliensis, popularly known as the rubber tree, is the main source of raw material for the production of natural rubber in the world. To characterize the fungal communities that inhabit the tissues of this species, a total of 550 endophytic fungi were isolated, of which 212 were from native trees located in the state of Acre and 338 in the state of Amazonas. These fungi were grouped into 115 OTUs. The phylum Ascomycota was dominant (93%) and the most abundant isolates belonged to the families Glomerallaceae (genus Colletotrichum), Diaporthaceae (genus Diaporthe), Nectriaceae (genus Fusarium), Hypocreaceae (genus Trichoderma), and Trichocomaceae (genus Penicillium). The diversity and richness of fungi in the state of Acre did not differ significantly between leaves, stems, and roots; however, in the state of Amazonas, the diversity was greater in the stems and roots than in the leaves. In general, the diversity of endophytic fungi was greater in the state of Acre. Comparisons between communities of fungi showed more differences between those that inhabit different tissues than in different states. Furthermore, the fungal communities of roots and stems were similar, and both these were dissimilar from leaves. Isolates identified in this study will be tested for their potential to produce metabolites of interest for industry and for the sustainable development of agribusiness.

Published
2020

39. Self-regulation of TNF-α Induces Dysfunction of Endothelial Colony-forming Cells from Patients with Venous Thromboembolic Disease

Author

Dafné Moreno-Lorenzana, Patricia Torres-Barrera, Gabriela Flores-Lopez, María Antonieta Chávez-González, Irma Isordia-Salas, Mervin C. Yoder, Abraham Majluf-Cruz, and José Antonio Alvarado-Moreno

Subjects
Adult, Young Adult, Tumor Necrosis Factor-alpha, NF-kappa B, Humans, Endothelial Cells, General Medicine, Middle Aged, Tumor Suppressor Protein p53, Self-Control
Abstract

Endothelial colony-forming cells (ECFCs) contribute to postnatal vasculogenesis. In venous thromboembolic disease (VTD), they are functionally abnormal and produce high concentrations of TNF-α.To analyze the TNF-α signaling pathway and its relationship with the expression of cell-cycle regulators.Mononuclear cells (MNCs) were collected from the peripheral blood of 20 healthy human volunteers (controls) and 30 patients with VTD matched by age (20-50 years) and sex to obtain ECFCs. We analyzed the relative quantification of the gene transcripts of TNF, NFkB1, PLAU, HMOX1, GSS, eNOS, CDKN1A, and CDKN1B through quantitative RT-PCR (qRT-PCR assays). Identification of NF-κB and activated targets of each pathway: NF-κB (Ser536); IκBα (Ser32/Ser36); p38 (Thr180/Tyr182) JNK (Thr183/Tyr185), p53 and cell-cycle regulators: p16, p18, p21, p27, p57, Cyclin D, Cyclin E, Cyclin A, Cyclin B, CDK2, CDK4; cell-cycle status was determined by KI-67 and 7-AAD. Cells were analyzed with flow cytometry and the FlowJo vX software.In ECFCs from VTD patients, TNF-α receptor and NFkB were overexpressed and hyper-phosphorylated; eNOS and HMOX1 were down-regulated; cell-cycle regulators (p53, p18, p21) were elevated. In addition, the cell cycle was locked in the G2 phase.Our results strongly suggest that these molecular alterations in the pathway of TNF-α and cell cycle regulation induce endothelial dysfunction, reduced proliferation potential and vascular regeneration, and consequently, the occurrence of new thrombotic events.

Published
2022

40. Diabetic Ketoacidosis Associated with Thyroxine (T4) Toxicosis and Thyrotoxic Cardiomyopathy

Author

Edinson Dante Meregildo Rodriguez, Luis Iván Gordillo Velásquez, and José Gustavo Alvarado Moreno

Subjects
thyroid storm, thyrotoxicosis, diabetic ketoacidosis, cardiomyopathy, Medicine (General), R5-920
Abstract

Thyrotoxicosis and diabetic ketoacidosis (DKA) both may present as endocrine emergencies and may have devastating consequences if not diagnosed and managed promptly and effectively. The combination of diabetes mellitus (DM) with thyrotoxicosis is well known, and one condition usually precedes the other. Furthermore, thyrotoxicosis is complicated by some degree of cardiomyopathy in at least 5% de patients; but the coexistence of DKA, thyroxin (T4) toxicosis, and acute cardiomyopathy is extremely rare. We describe a case of a man, previously diagnosed with DM but with no past history of thyroid disease, who presented with shock and severe DKA that did not improve despite optimal therapy. The patient evolved with acute pulmonary edema, elevated troponin levels, severe left ventricular systolic dysfunction, and clinical and laboratory evidence of thyroxin (T4) toxicosis and thyrotoxic cardiomyopathy. Subsequently, the patient evolved favorably with general support and appropriate therapy for DKA and thyrotoxicosis (hydrocortisone, methimazole, Lugol’s solution) and was discharged a few days later.

Published
2018
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41. Estudio comparativo de técnicas espaciales para la identificación de defectos en textiles

Author

José Armando Fernández, José David Alvarado Moreno, Diego Mauricio Florián, and César Augusto Sánchez

Subjects
textura, procesamiento de imágenes, redes neuronales, patrones locales binarios, energía de laws, matriz de co-ocurrencia., Technology, Engineering (General). Civil engineering (General), TA1-2040
Abstract

En este artículo se utilizan técnicas de procesamiento de imágenes para la detección de defectos en textiles en el sector industrial. Se evalúa el desempeño de tres técnicas espaciales con descriptores estadísticos para la extracción de características que son finalmente clasificados mediante una red neuronal. Para el desarrollo del proyecto se utilizó la base de datos texUAN del grupo de investigación GEPRO de la universidad Antonio Nariño.

Published
2010
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42. Abo Blood Group, Atherothrombotic Comorbidities, and COVID-19: A Case-Control Study of their Association in the Mexican Population

Author

Gamboa-Aguilar, Jacqueline, primary, Zamorano-Montaño, Ángela Carele, additional, Enríquez-Osorio, Aldo, additional, Torres-Cubillas, Wendoline, additional, López-Arroyo, José Luis, additional, Chapol, José Agustín Mata, additional, Zurita-Martínez, Hugo, additional, Pascual, Julio Robledo, additional, Saldaña-Campos, Eli, additional, Rojas-Castillejos, Flavio, additional, Madera-Maldonado, Cristina Elizabeth, additional, Peñafiel, Christian Omar Ramos, additional, Maldonado, Emanuel Bermeo, additional, Rascón, Rafael García, additional, Hernández-Juárez, Jesús, additional, Silos-Briones, Graciela, additional, Domínguez, Salvador de la Maza, additional, Pérez-Ramírez, Óscar de Jesús, additional, Sosa-Camas, Rosa Elena, additional, Romero-López, Cuauhtémoc, additional, Guzmán-Chores, Laura, additional, Amador-Sánchez, Raquel, additional, Ledesma-de la Cruz, Cindy, additional, Campos-Cabrera, Gregorio, additional, Ramírez-Chávez, Laura L., additional, Esparza-García, Juan Carlos, additional, Vela-Ojeda, Jorge, additional, García-Chávez, Jaime, additional, González-Trejo, José Joaquín, additional, Rodríguez-Mejorada, Silvia Margarita, additional, Rosado-Castro, Rilke Armando, additional, de Arredondo, Raúl Agustín Sobrino-Martínez, additional, Pérez-Hernández, Víctor Hugo, additional, Majluf-Cruz, Karim, additional, Domínguez-Reyes, Víctor, additional, Arreola-Diaz, Rodrigo, additional, Alvarado-Moreno, José Antonio, additional, and Majluf-Cruz, Abraham, additional

Published
2022
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43. Las redes sociales un tema de salud pública

Author

Alvarado Moreno, Karen Eliana, Ruiz, Eduardo, and Ruiz Cárdenas, Eduardo

Subjects
REDES SOCIALES, social networks, communication, Health, salud, comunicación, News, SALUD PUBLICA, Noticias
Abstract

No cabe la menor duda que las redes sociales son parte esencial de la vida, gracias a estas se puede contactar con gente alrededor del mundo en segundos. Y no solo se han vuelto el canal más eficiente, y óptimo para poder comunicarse sin importar la distancia; también son el medio de tráfico masivo de información más grande, jamás imaginado desde la creación de internet. Solo basta con contar con un celular con cámara, y señal de internet, para trasmitir algo y que lo puedan ver en cualquier parte del mundo. Compartir todo tipo de información es el pan de cada día de las redes sociales, no solo información privada entre dos personas en un chat en particular; asimismo información pública de toda clase, desde información gubernamental, hasta datos personales, sin autorización previa de la persona, que muchas veces viola las reglas y políticas con las que cuentan las redes sociales. Se puede decir que aquel que no cuente con redes sociales podría tener una gran desventaja frente a los demás, no solo perdería la oportunidad de comunicarse lo más rápido posible con un familiar o amigo que este en otra latitud. También perdería la ventaja de “informarse”, y no solo acerca de la economía, la política, la ciencia, y tantas otras cosas que contribuyen al conocimiento humano, haciéndolo mucho más rápido de lo que lo puede hacer la televisión, un periódico físico, o un libro. De la misma manera tiene una gran desventaja por no conocer al instante cosas tan simples y cotidianas como: que cierres viales se podrían estar presentando, cuales superficies de comercio abrirán o no abrirán, que medidas tomará la alcaldía municipal con respecto a algo, o que puntos de vacunación están habilitados para vacunarse contra el covid-19. There is no doubt that social networks are an essential part of life, thanks to them you can contact people around the world in seconds. And not only have they become the most efficient channel, and optimal to be able to communicate regardless of distance; They are also the largest mass traffic medium ever imagined since the creation of the internet. All you have to do is have a cell phone with a camera, and an internet signal, to transmit something and be able to see it anywhere in the world. Sharing all kinds of information is the daily bread of social networks, not just private information between two people in a particular chat; also public information of all kinds, from government information to personal data, without prior authorization of the person, which often violates the rules and policies of social networks. It can be said that those who do not have social networks could have a great disadvantage compared to others, not only would they lose the opportunity to communicate as quickly as possible with a family member or friend who is in another latitude. You would also lose the advantage of “getting informed”, and not only about economics, politics, science, and so many other things that contribute to human knowledge, doing it much faster than television, a physical newspaper, can do it. or a book. In the same way, it has a great disadvantage for not knowing instantly things as simple and everyday as: what road closures could be occurring, which commercial areas will open or not open, what measures the municipal mayor's office will take with respect to something, or what Vaccination points are authorized to be vaccinated against covid-19. Pregrado

Published
2021

46. High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse

Author

Martha Velázquez-Avila, Elisa Dorantes-Acosta, José Antonio Alvarado-Moreno, Klemens Rottner, Briceida López-Martínez, Juan Carlos Balandrán, David Dozal, Mirella Velázquez-Avila, Dalia Ramírez-Ramírez, Michael Schnoor, Rosana Pelayo, Alfonso Felipe-López, Matthias Schaks, Porfirio Nava, Antonio Sandoval, Jessica L Prieto-Chávez, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
0301 basic medicine, Male, Cancer Research, Cell, Apoptosis, Mice, 0302 clinical medicine, Tumor Cells, Cultured, Child, biology, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Gene Expression Regulation, Neoplastic, Survival Rate, Leukemia, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Bone marrow neoplasm, Child, Preschool, Female, Infiltration (medical), Cortactin, Cell biology, Adolescent, Mice, Nude, macromolecular substances, Article, 03 medical and health sciences, Precursor cell, medicine, Biomarkers, Tumor, Animals, Humans, Cell Proliferation, Acute lymphocytic leukaemia, business.industry, Cell growth, Infant, Newborn, Transendothelial and Transepithelial Migration, Infant, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, biology.protein, Cancer research, Bone marrow, Neoplasm Recurrence, Local, business, Bone Marrow Neoplasms, Follow-Up Studies
Abstract

Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leukemia (B-ALL) being the most frequent childhood malignancy. Relapse, treatment failure and organ infiltration worsen the prognosis, warranting a better understanding of the implicated mechanisms. Cortactin is an actin-binding protein involved in cell adhesion and migration that is overexpressed in many solid tumors and in adult B-cell chronic lymphocytic leukemia. Here, we investigated cortactin expression and potential impact on infiltration and disease prognosis in childhood B-ALL. B-ALL cell lines and precursor cells from bone marrow (BM) and cerebrospinal fluid (CSF) of B-ALL patients indeed overexpressed cortactin. In CXCL12-induced transendothelial migration assays, transmigrated B-ALL cells had highest cortactin expression. In xenotransplantation models, only cortactinhigh-leukemic cells infiltrated lungs, brain, and testis; and they colonized more easily hypoxic BM organoids. Importantly, cortactin-depleted B-ALL cells were significantly less efficient in transendothelial migration, organ infiltration and BM colonization. Clinical data highlighted a significant correlation between high cortactin levels and BM relapse in drug-resistant high-risk B-ALL patients. Our results emphasize the importance of cortactin in B-ALL organ infiltration and BM relapse and its potential as diagnostic tool to identify high-risk patients and optimize their treatments.

Published
2018

48. Design of an Auxiliary Mechanical System for the Diagnosis of Lordosis and Scoliosis

Author

Pablo Moreno-Garibaldi, Juan Carlos Hermida-Ochoa, Erik Omar Alvarado-Alcántara, Carolina Alvarado-Moreno, Juan Alfonso Beltrán-Fernández, Itzel Bantle-Chávez, and Luis Héctor Hernández-Gómez

Subjects
Mechanical system, Orthodontics, medicine.medical_specialty, Lordosis, business.industry, Radiological weapon, Orthopedic surgery, Work (physics), medicine, Scoliosis, medicine.disease, business
Abstract

Scoliosis and lordosis are medical conditions, which present an atypical curvature of the spine. These deformations can be easily diagnosed, altogether with the degree of their severity through orthopedic measurement processes and clinical reviews. However, the preformed studies which classify the severity of these deformations are, in their majority, empirical and present great opportunity for improvement. Therefore, they are based on radiographies that offer a clear image of the spine, but present the problem of a constant patient’s exposition to ionizing radiation and as a consequence an increment of potential hazards for health. This also means, results are subject to the physician’s interpretation and expertise. The present work intends to describe and analyze the design and function of a mechanical system that is capable of significantly reducing the radiological exposure of patients with scoliosis and lordosis. The main goal of this device is to diagnose both deformations by obtaining the angles of curvature of the patient’s spine, using a method that does not depend entirely on human interpretation.

Published
2021

49. Diseño e implementación de un Gateway IoT multiprotocolo

Author

Macías Naranjo, Robert José, Pinilla, Harold, Castellano, Eduardo Ernesto, Sánchez, Andrés Armando, Alvarado Moreno, José David, Macías Naranjo, Robert José, Pinilla, Harold, Castellano, Eduardo Ernesto, Sánchez, Andrés Armando, and Alvarado Moreno, José David

Abstract

This paper describes the implementation of an IoT gateway that allows the exchange of data through different wireless technologies and forwarding of such data to the Internet. The proposed gateway has important advantages such as: supporting for multiprotocol interconnectivity; the remote configuration of wireless nodes for sensor and actuators management; a flexible algorithm to translate the data obtained by sensors into a uniform format for transmission to a cloud server; low energy consumption due to efficient data transfer over the MQTT protocol. In order to demonstrate the usefulness of the developed gateway, a proof-of-concept test was implemented. The implemented scenario consists of 2 wireless nodes responsible for sensing environmental variables and transmitting data to the gateway node through different communication protocols. The obtained results show the feasibility for simultaneous data transmission from the remote wireless nodes to the gateway. Metrics on energy consumption in the devices are also presented., En este artículo se describe la implementación de un gateway IoT que permite el intercambio de datos a través de diferentes tecnologías inalámbricas y el reenvío de dichos datos a Internet. El gateway propuesto incorpora importantes ventajas como: la interconectividad con diferentes protocolos; permite la configuración remota de nodos inalámbricos para la gestión de sensores y actuadores; utiliza un algoritmo flexible para traducir los datos obtenidos por los sensores a un formato uniforme para la transmisión hacia un servidor en la nube; utiliza el protocolo MQTT, el cual permite la difusión de datos de forma simple para minimizar los recursos utilizados del gateway. Con el fin de demostrar el funcionamiento del gateway desarrollado, se implementó una prueba de concepto compuesta por 2 nodos inalámbricos encargados de sensar 6 variables ambientales y transmitiendo dichos datos al gateway a través de diferentes protocolos de comunicación. Los resultados presentados muestran la transmisión de la información de manera simultánea, desde los nodos inalámbricos remotos hacia el gateway. Además, se presentan métricas sobre el consumo de energía en los diferentes dispositivos que componen el escenario desarrollado.

Published
2021

50. Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1

Author

Jessica Purizaca, Adriana Contreras-Quiroz, Elisa Dorantes-Acosta, Eduardo Vadillo, Lourdes Arriaga-Pizano, Silvestre Fuentes-Figueroa, Horacio Villagomez-Barragán, Patricia Flores-Guzmán, Antonio Alvarado-Moreno, Hector Mayani, Isaura Meza, Rosaura Hernandez, Sara Huerta-Yepez, and Rosana Pelayo

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Substantial progress on understanding the cell hierarchy within ALL bone marrow (BM) has been recorded in the last few years, suggesting that both primitive cell fractions and committed lymphoid blasts with immature stem cell-like properties contain leukemia-initiating cells. Nevertheless, the biology of the early progenitors that initiate the lymphoid program remains elusive. The aim of the present study was to investigate the ability of lymphoid progenitors from B-cell precursor ALL BM to proliferate and undergo multilineage differentiation. By phenotype analyses, in vitro proliferation assays, and controlled culture systems, the lymphoid differentiation potentials were evaluated in BM primitive populations from B-cell precursor ALL pediatric patients. When compared to their normal counterparts, functional stem and progenitor cell contents were substantially reduced in ALL BM. Moreover, neither B nor NK or dendritic lymphoid-cell populations developed recurrently from highly purified ALL-lymphoid progenitors, and their proliferation and cell cycle status revealed limited proliferative capacity. Interestingly, a number of quiescence-associated transcription factors were elevated, including the transcriptional repressor Gfi-1, which was highly expressed in primitive CD34+ cells. Together, our findings reveal major functional defects in the primitive hematopoietic component of ALL BM. A possible contribution of high levels of Gfi-1 expression in the regulation of the stem/progenitor cell biology is suggested.

Published
2013
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