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Decisions about when to start, how long to continue and how to end cardiopulmonary resuscitation (CPR) are important in the management of these critically ill patients. The aim of our study is to determine the factors that can help in the early prediction of patients in whom spontaneous circulation can be restored during CPR. Patients who had arrest due to nontraumatic causes were included in the study. The patients whose spontaneous circulation (ROSC) was restored in the emergency service and who were hospitalized in intensive care were included in ROSC (+) group, while the patients who did not have ROSC and who became exitus were included in ROSC (-) group. Patients’ demographic characteristics, chronic diseases, places of arrest, admission laboratory values and possible causes of death were compared between ROSC groups. This study was conducted with the retrospective examination of 309, 118 (38.2%) female and 191 (61.8%) male, cardiopulmonary arrest cases. ROSC was achieved in 94 (30.4%) of the patients who underwent CPR. It was found that a 0,1 unit increase in pH value increased the probability of ROSC by 38% [OR: 1,38 (95% CI: 1.22-1.55), p

Beta-adrenergic receptor antagonists potentially risk causing fatal poisoning when taken over the daily recommended doses. The aim of this study is to investigate the differences and potential dose-related effects of propranolol and metoprolol toxicity depending on their selectivity. This 7-year-long retrospective cohort study was conducted among on 43 adult patients who received overdose propranolol (n= 22) and metoprolol (n= 21). Patients were divided into groups, with a daily overdose ≥ 240 mg/day for propranolol, ≥ 200 mg/day for metoprolol, and toxic dose ≥ 400 mg/day for both drugs. The groups were compared in terms of admission symptoms, heart rate, blood pressure, electrocardiography findings, cardiovascular effects, toxicity severity scores, treatment, follow-up times, and outcomes. Thirty-four (79.1%) of the patients who exceeded the daily dose were female, and there were no statistically significant differences between the groups in terms of gender (p= 0,281). The mean age was 29 (18-72) years, and there were no statistically significant differences between groups in terms of mean age (p= 0,192). When the vitals of the patients who exceeded the daily dose was examined, it was found that 23 (54.8%) patients had bradycardia, and 20 (46.5%) patients had hypotension. 65.2% of the bradycardia patients and 70% of the hypotensive patients were in the propranolol overdose group (p= 0,030 p= 0,021, respectively). Mean dose of symptomatic propranolol overdose patients (n= 12) was found as 1256 (280-2000) mg, mean dose of symptomatic metoprolol overdose patients (n= 11) was found as 559 (250-1000) mg. When toxic dose (≥ 400 mg) intakes were compared, more cardiovascular effects were observed in the propranolol group (p= 0,014). As a result, it was determined that Propranolol overdose has more cardiovascular effects than metoprolol overdose and there is a linear dose-symptom relationship for Propranolol.

Aortic dissection is a fatal cardiovascular health problem. Chest and back pain are among the common complaints of the patients, and they may also apply with atypical clinics. It is very difficult to diagnose with examination and anamnesis, especially in patients who present with poor consciousness and stroke symptoms. In this study, we wanted to present a 62-year-old female patient who had syncope at home and was unconscious for about 1 hour, has stroke symptoms, and aortic dissection was detected in her examinations. When no hemorrhage was detected in non-contrast brain CT, neck and brain contrast-enhanced CT angiography imaging was performed. Aortic dissection flap extending to the right carotid communis was detected in the imaging. Clinicians should pay attention to detailed examination and be alert for further examinations in order not to harm the patient in terms of underlying causes, especially in unconscious patients who have a stroke clinic and cannot express their complaints in a healthy way.

Bu çalışmanın amacı Borsa İstanbul’da (BİST) yer alan altı endeks için (XU100, XTUMY, XUHIZ, XUMAL, XUSIN, XUTEK) etkin piyasa hipotezinin (EPH) geçerliliğini test etmektir. Bunun için ADF, RALS-ADF, Fourier-ADF ve Fourier-KSS birim kök testlerinden yararlanılmıştır. Analiz dönemi olarak veri bulunabilirliği açısından her bir endeks için en uzun dönem kullanılmıştır. Literatürden farklı olarak BİST’de yer alan altı endeks için EPH’nin geçerliliği aynı anda hem yapısal kırılmalar hem normal dağılmama durumu hem de doğrusal olmama durumu dikkate alınarak kapsamlı ve karşılaştırmalı bir şekilde incelenmiştir. Elde edilen ampirik bulgulara göre XUHIZ endeksinde uygulanan tüm birim kök testlerinde boş hipotez reddedilememiştir. Yani XUHIZ endeksi için etkin piyasa hipotezi geçerli doğrultusunda güçlü kanıtlar elde edilmiştir. Aksine XUMAL endeksinde ise uygulanan bütün birim kök testleri sonucunda boş hipotez reddedilerek etkin piyasa hipotezinin geçersiz olduğuna yönelik sonuçlar elde edilmiştir. Diğer endekslerde ise yapısal kırılmaların ve doğrusal olmama durumunun dikkate alınmasının sonuçlar üzerinde farklılıklara neden olduğu gözlemlenmiştir. Bu durum da veri setine uygun test seçiminin önemini öne çıkarmaktadır., The aim of this study is to test the validity of the efficient market hypothesis for six indexes (XU100, XTUMY, XUHIZ, XUMAL, XUSIN, XUTEK) in BIST. For this, ADF, RALS-ADF, Fourier-ADF and Fourier-KSS unit root tests were used. The longest period was used for each index in terms of data availability as the analysis period. Unlike the literature, the validity of the efficient market hypothesis for six indices in the BIST has been comprehensively and comparatively examined by considering both structural breaks, non-normal distribution and non-linearity at the same time. According to the empirical findings, the null hypothesis could not be rejected in all unit root tests applied in the XUHIZ index. In other words, strong evidence has been obtained for the XUHIZ index in line with the effective market hypothesis. On the contrary, as a result of all unit root tests applied in the XUMAL index, the null hypothesis was rejected and the results indicating that the efficient market hypothesis was invalid were obtained. In other indices, it was observed that considering structural breaks and nonlinearity caused differences in the results. This situation highlights the importance of choosing the appropriate test for the data set.