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29 results on '"Altimiras, Francisco"'

1. Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease

Author

Hurley, Michael J, Urra, Claudio, Garduno, B Maximiliano, Bruno, Agostino, Kimbell, Allison, Wilkinson, Brent, Marino-Buslje, Cristina, Ezquer, Marcelo, Ezquer, Fernando, Aburto, Pedro F, Poulin, Elie, Vasquez, Rodrigo A, Deacon, Robert, Avila, Ariel, Altimiras, Francisco, Vanderklish, Peter Whitney, Zampieri, Guido, Angione, Claudio, Constantino, Gabriele, Holmes, Todd C, Coba, Marcelo P, Xu, Xiangmin, and Cogram, Patricia

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative, Brain Disorders, Aging, Genetics, Human Genome, Acquired Cognitive Impairment, Dementia, Aetiology, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Neurological, Alzheimer's disease, aging, genome, APOE, amyloids, lipid droplets, Octodon degus, drug development, Biochemistry and Cell Biology, Cognitive Sciences, Biological psychology
Abstract

The degu (Octodon degus) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E (Apoe) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease.

Published
2022

3. A Binary Whale Algorithm Applied to Knapsack Problem

Author

Moraga, Paola, Valenzuela, Pamela, Altimiras, Francisco, Lopez, Luis, Rubio, José-Miguel, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2021
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4. A Machine Learning Whale Algorithm Applied to the Resource Allocation Problems

Author

Jorquera, Lorena, Moraga, Paola, Altimiras, Francisco, Valenzuela, Pamela, Rubio, José-Miguel, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2021
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6. A Percentil Gravitational Search Algorithm an Aplication to the Set Covering Problem

Author

Pavez, Leonardo, Altimiras, Francisco, Villavicencio, Gabriel, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2020
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7. A K-means Bat Algorithm Applied to the Knapsack Problem

Author

Pavez, Leonardo, Altimiras, Francisco, Villavicencio, Gabriel, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2020
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8. A K-means Bat Optimisation Algorithm Applied to the Set Covering Problem

Author

Pavez, Leonardo, Altimiras, Francisco, Villavicencio, Gabriel, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Silhavy, Radek, editor, Silhavy, Petr, editor, and Prokopova, Zdenka, editor

Published
2020
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9. A K-Means Grasshopper Optimisation Algorithm Applied to the Set Covering Problem

Author

Villavicencio, Gabriel, Valenzuela, Matias, Altimiras, Francisco, Moraga, Paola, Pinto, Hernan, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Silhavy, Radek, editor

Published
2020
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10. A Percentil Bat Algorithm an Application to the Set Covering Problem

Author

Jorquera, Lorena, Valenzuela, Pamela, Altimiras, Francisco, Moraga, Paola, Villavicencio, Gabriel, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Silhavy, Radek, editor

Published
2020
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11. Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

Author

Reyes, Samantha T., Deacon, Robert M. J., Guo, Scarlett G., Altimiras, Francisco J., Castillo, Jessa B., van der Wildt, Berend, Morales, Aimara P., Park, Jun Hyung, Klamer, Daniel, Rosenberg, Jarrett, Oberman, Lindsay M., Rebowe, Nell, Sprouse, Jeffrey, Missling, Christopher U., McCurdy, Christopher R., Cogram, Patricia, Kaufmann, Walter E., and Chin, Frederick T.

Published
2021
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17. Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease

Author

Hurley, Michael J., primary, Urra, Claudio, additional, Garduno, B. Maximiliano, additional, Bruno, Agostino, additional, Kimbell, Allison, additional, Wilkinson, Brent, additional, Marino-Buslje, Cristina, additional, Ezquer, Marcelo, additional, Ezquer, Fernando, additional, Aburto, Pedro F., additional, Poulin, Elie, additional, Vasquez, Rodrigo A., additional, Deacon, Robert, additional, Avila, Ariel, additional, Altimiras, Francisco, additional, Whitney-Vanderklish, Peter, additional, Zampieri, Guido, additional, Angione, Claudio, additional, Constantino, Gabriele, additional, Holmes, Todd C., additional, Coba, Marcelo P., additional, Xu, Xiangmin, additional, and Cogram, Patricia, additional

Published
2022
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19. A Binary Machine Learning Cuckoo Search Algorithm Improved by a Local Search Operator for the Set-Union Knapsack Problem

Author

García, José, primary, Lemus-Romani, José, additional, Altimiras, Francisco, additional, Crawford, Broderick, additional, Soto, Ricardo, additional, Becerra-Rozas, Marcelo, additional, Moraga, Paola, additional, Becerra, Alex Paz, additional, Fritz, Alvaro Peña, additional, Rubio, Jose-Miguel, additional, and Astorga, Gino, additional

Published
2021
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22. Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy

Author

Reyes, Samantha T., primary, Deacon, Robert M.J., additional, Guo, Scarlett G., additional, Castillo, Jessa B., additional, Wildt, Berend van der, additional, Morales, Aimara P., additional, Park, Jun Hyung, additional, Klamer, Daniel, additional, Rosenberg, Jarrett, additional, Oberman, Lindsay M., additional, Rebowe, Nell, additional, Sprouse, Jeffrey, additional, Missling, Christopher U., additional, Cogram, Patricia, additional, Kaufmann, Walter E., additional, Chin, Frederick T., additional, McCurdy, Christopher R., additional, and Altimiras, Francisco J., additional

Published
2021
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26. Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease

Author

Altimiras, Francisco, primary, Uszczynska-Ratajczak, Barbara, additional, Camara, Francisco, additional, Vlasova, Anna, additional, Palumbo, Emilio, additional, Newhouse, Stephen, additional, Deacon, Robert M. J., additional, Farias, Leandro A. E., additional, Hurley, Michael J., additional, Loyola, David E., additional, Vásquez, Rodrigo A., additional, Dobson, Richard, additional, Guigó, Roderic, additional, and Cogram, Patricia, additional

Published
2017
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28. Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation

Author

Deacon, Robert, primary, Altimiras, Francisco, additional, Bazan-Leon, Enrique, additional, Pyarasani, Rhada, additional, Nachtigall, Fabiane, additional, Santos, Leonardo, additional, Tsolaki, Anthony, additional, Pednekar, Lina, additional, Kishore, Uday, additional, Biekofsky, Rodolfo, additional, Vasquez, Rodrigo, additional, and Cogram, Patricia, additional

Published
2015
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29. Natural AD-Like Neuropathology in Octodon degus: Impaired Burrowing and Neuroinflammation

Author

M.J. Deacon, Robert, J. Altimiras, Francisco, A. Bazan-Leon, Enrique, D. Pyarasani, Rhada, M. Nachtigall, Fabiane, S. Santos, Leonardo, G. Tsolaki, Anthony, Pednekar, Lina, Kishore, Uday, R. Biekofsky, Rodolfo, A. Vasquez, Rodrigo, and Cogram, Patricia

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs of AD, including amyloid- (A) and tau deposits, as well as a decline in cognition with age. Firstly, the present work introduces a novel behavioral assessment for O. degus - the burrowing test - which appears to be a useful tool for detecting neurodegeneration in the O. degus model for AD. Such characterization has potentially wide-ranging implications, because many of these changes in species-typical behaviors are reminiscent of the impairments in activities of daily living (ADL), so characteristic of human AD. Furthermore, the present work characterizes the ADlike neuropathology in O. degus from a gene expression point of view, revealing a number of previously unreported AD biomarkers, which are found in human AD: amyloid precursor protein (APP), apolipoprotein E (ApoE), oxidative stressrelated genes from the NFE2L2 and PPAR pathway, as well as pro-inflammatory cytokines and complement proteins, in agreement with the known link between neurodegeneration and neuroinflammation. In summary, the present results confirm a natural neuropathology in O. degus with similar characteristics to AD at behavioral, cellular and molecular levels. These characteristics put O. degus in a singular position as a natural rodent model for research into AD pathogenesis and therapeutics against AD.

Published
2015

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