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4. Research Agenda in Childhood Impairing Emotional Outbursts: A Report of the AACAP Presidential Taskforce on Emotional Dysregulation

Author

Althoff, Robert R., Singh, Manpreet K., Stringaris, Argyris, Constantino, John N., Amaya-Jackson, Lisa, Benton, Tami D., Bellonci, Christopher, Bostic, Jeff Q., Chua, Jaclyn Datar, Findling, Robert L., Galanter, Cathryn A., Gerson, Ruth S., McClellan, Jon M., Sorter, Michael T., Waxmonsky, James G., and Carlson, Gabrielle A.

Published
2024
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5. Editors’ Note and Special Communication: Research Priorities in Child and Adolescent Mental Health Emerging From the COVID-19 Pandemic

Author

Novins, Douglas K, Stoddard, Joel, Althoff, Robert R, Charach, Alice, Cortese, Samuele, Cullen, Kathryn Regan, Frazier, Jean A, Glatt, Stephen J, Henderson, Schuyler W, Herringa, Ryan J, Hulvershorn, Leslie, Kieling, Christian, McBride, Anne B, McCauley, Elizabeth, Middeldorp, Christel M, Reiersen, Angela M, Rockhill, Carol M, Sagot, Adam J, Scahill, Lawrence, Simonoff, Emily, Stewart, S Evelyn, Szigethy, Eva, Taylor, Jerome H, White, Tonya, and Zima, Bonnie T

Subjects
Pediatric, Mental Health, Behavioral and Social Science, 8.1 Organisation and delivery of services, Health and social care services research, Mental health, Good Health and Well Being, Adolescent, COVID-19, Child, Communication, Humans, Interdisciplinary Research, Pandemics, Research, SARS-CoV-2, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology
Abstract

Over the last year, the coronavirus disease 2019 (COVID-19) pandemic has resulted in profound disruptions across the globe, with school closures, social isolation, job loss, illness, and death affecting the lives of children and families in myriad ways. In an Editors' Note in our June 2020 issue,1 our senior editorial team described this Journal's role in advancing knowledge in child and adolescent mental health during the pandemic and outlined areas we identified as important for science and practice in our field. Since then, the Journal has published articles on the impacts of the pandemic on child and adolescent mental health and service systems,2-5 which are available in a special collection accessible through the Journal's website.6 Alongside many opinion papers, the pace of publication of empirical research in this area is rapidly expanding, covering important issues such as increased frequency of mental health symptoms among children and adolescents3,5,7-10 and changes in patterns of clinical service use such as emergency department visits.11-14 As the Senior Editors prepared that Editors' Note, they were acutely aware that the priorities that they identified were broad and generated by only a small group of scientists and clinicians. Although this had the advantage of enabling us to get this information out to readers quickly, we decided that a more systematic approach to developing recommendations for research priorities would be of greater long-term value. We were particularly influenced by the efforts of the partnership between the UK Academy of Medical Scientists and a UK mental health research charity (MQ: Transforming Mental Health) to detail COVID-19-related research priorities for "Mental Health Science" that was published online by Holmes et al. in The Lancet Psychiatry in April 2020.15 Consistent with its focus on mental health research across the lifespan, several recommendations highlighted child development and children's mental health. However, a more detailed assessment of research priorities related to child and adolescent mental health was beyond the scope of that paper. Furthermore, the publication of that position paper preceded the death of George Floyd at the hands of Minneapolis police on May 25, 2020, which re-energized efforts to acknowledge and to address racism and healthcare disparities in the United States and many other countries. To build upon the JAACAP Editors' Note1 and the work of Holmes et al.,15 we conducted an international survey of professionals-practitioners and researchers-working on child and adolescent development and pediatric mental health to identify concerns about the impact of the pandemic on children, adolescents, and their families, as well as what is helping families navigate these impacts, and the specific research topics that are of greatest importance.

Published
2021

6. Commentary on "The Challenge of Transforming the Diagnostic System of Personality Disorders".

Author

Hopwood, Christopher J, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clerq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins-Sweatt, Stephanie N, Ormel, Johan, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Psychology, Clinical and Health Psychology, Social and Personality Psychology, Applied and Developmental Psychology, Psychiatry, Applied and developmental psychology, Clinical and health psychology, Social and personality psychology
Published
2020

8. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Author

Thompson, Paul M, Jahanshad, Neda, Ching, Christopher RK, Salminen, Lauren E, Thomopoulos, Sophia I, Bright, Joanna, Baune, Bernhard T, Bertolín, Sara, Bralten, Janita, Bruin, Willem B, Bülow, Robin, Chen, Jian, Chye, Yann, Dannlowski, Udo, de Kovel, Carolien GF, Donohoe, Gary, Eyler, Lisa T, Faraone, Stephen V, Favre, Pauline, Filippi, Courtney A, Frodl, Thomas, Garijo, Daniel, Gil, Yolanda, Grabe, Hans J, Grasby, Katrina L, Hajek, Tomas, Han, Laura KM, Hatton, Sean N, Hilbert, Kevin, Ho, Tiffany C, Holleran, Laurena, Homuth, Georg, Hosten, Norbert, Houenou, Josselin, Ivanov, Iliyan, Jia, Tianye, Kelly, Sinead, Klein, Marieke, Kwon, Jun Soo, Laansma, Max A, Leerssen, Jeanne, Lueken, Ulrike, Nunes, Abraham, Neill, Joseph O', Opel, Nils, Piras, Fabrizio, Piras, Federica, Postema, Merel C, Pozzi, Elena, Shatokhina, Natalia, Soriano-Mas, Carles, Spalletta, Gianfranco, Sun, Daqiang, Teumer, Alexander, Tilot, Amanda K, Tozzi, Leonardo, van der Merwe, Celia, Van Someren, Eus JW, van Wingen, Guido A, Völzke, Henry, Walton, Esther, Wang, Lei, Winkler, Anderson M, Wittfeld, Katharina, Wright, Margaret J, Yun, Je-Yeon, Zhang, Guohao, Zhang-James, Yanli, Adhikari, Bhim M, Agartz, Ingrid, Aghajani, Moji, Aleman, André, Althoff, Robert R, Altmann, Andre, Andreassen, Ole A, Baron, David A, Bartnik-Olson, Brenda L, Marie Bas-Hoogendam, Janna, Baskin-Sommers, Arielle R, Bearden, Carrie E, Berner, Laura A, Boedhoe, Premika SW, Brouwer, Rachel M, Buitelaar, Jan K, Caeyenberghs, Karen, Cecil, Charlotte AM, Cohen, Ronald A, Cole, James H, Conrod, Patricia J, De Brito, Stephane A, de Zwarte, Sonja MC, Dennis, Emily L, Desrivieres, Sylvane, Dima, Danai, Ehrlich, Stefan, Esopenko, Carrie, Fairchild, Graeme, Fisher, Simon E, Fouche, Jean-Paul, and Francks, Clyde

Subjects
ENIGMA Consortium, Brain, Humans, Magnetic Resonance Imaging, Reproducibility of Results, Depressive Disorder, Major, Neuroimaging, Neurosciences, Clinical Research, Mental Health, Brain Disorders, Behavioral and Social Science, Genetics, Basic Behavioral and Social Science, Prevention, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Mental health, Neurological, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

Published
2020

9. Redefining Phenotypes to Advance Psychiatric Genetics: Implications From Hierarchical Taxonomy of Psychopathology

Author

Waszczuk, Monika A, Eaton, Nicholas R, Krueger, Robert F, Shackman, Alexander J, Waldman, Irwin D, Zald, David H, Lahey, Benjamin B, Patrick, Christopher J, Conway, Christopher C, Ormel, Johan, Hyman, Steven E, Fried, Eiko I, Forbes, Miriam K, Docherty, Anna R, Althoff, Robert R, Bach, Bo, Chmielewski, Michael, DeYoung, Colin G, Forbush, Kelsie T, Hallquist, Michael, Hopwood, Christopher J, Ivanova, Masha Y, Jonas, Katherine G, Latzman, Robert D, Markon, Kristian E, Mullins-Sweatt, Stephanie N, Pincus, Aaron L, Reininghaus, Ulrich, South, Susan C, Tackett, Jennifer L, Watson, David, Wright, Aidan GC, and Kotov, Roman

Subjects
Biotechnology, Genetics, Human Genome, Brain Disorders, Mental Health, Genetic Testing, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Humans, Mental Disorders, Phenotype, Psychiatry, Psychology, Clinical, behavior genetics, comorbidity, general factor, molecular genetics, nosology
Abstract

Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic categories. Specifically, genes are expected to operate at different levels of the HiTOP hierarchy, with some highly pleiotropic genes influencing higher order psychopathology (e.g., the general factor), whereas other genes conferring more specific risk for individual spectra (e.g., internalizing), subfactors (e.g., fear disorders), or narrow symptoms (e.g., mood instability). We propose that the HiTOP model aligns well with the current understanding of the higher order genetic structure of psychopathology that has emerged from a large body of family and twin studies. We also discuss the convergence between the HiTOP model and findings from recent molecular studies of psychopathology indicating broad genetic pleiotropy, such as cross-disorder SNP-based shared genetic covariance and polygenic risk scores, and we highlight molecular genetic studies that have successfully redefined phenotypes to enhance precision and statistical power. Finally, we suggest how to integrate a HiTOP approach into future molecular genetic research, including quantitative and hierarchical assessment tools for future data-collection and recommendations concerning phenotypic analyses. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Published
2020

11. Commentary on "The Challenge of Transforming the Diagnostic System of Personality Disorders".

Author

Hopwood, Christopher J, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clerq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins-Sweatt, Stephanie N, Ormel, Johan, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Psychology, Psychiatry
Published
2019

13. Brief Report: Me, Reporting on Myself--Preliminary Evaluation of the Criterion-Related Validity of the Theory of Mind Inventory-2 When Completed by Autistic Young Adults

Author

Crehan, Eileen T., Althoff, Robert R., Riehl, Hannah, Prelock, Patricia A., and Hutchins, Tiffany

Abstract

There is a need for increased understanding of self-report measures for autistic individuals. In this preliminary study, we examine how a theory of mind self-report relates to other self-report measures for groups of autistic and neurotypical individuals, as well as eye tracking outcomes. Expected patterns of relatedness emerged between self-reports and the eye tracking findings, which lends validity to the theory of mind measure. Self-report measures are critical for autistic individuals to share their own experiences and this is the first step in establishing a theory of mind self-report tool.

Published
2020
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14. The time has come for dimensional personality disorder diagnosis

Author

Hopwood, Christopher J, Kotov, Roman, Krueger, Robert F, Watson, David, Widiger, Thomas A, Althoff, Robert R, Ansell, Emily B, Bach, Bo, Bagby, R Michael, Blais, Mark A, Bornovalova, Marina A, Chmielewski, Michael, Cicero, David C, Conway, Christopher, De Clercq, Barbara, De Fruyt, Filip, Docherty, Anna R, Eaton, Nicholas R, Edens, John F, Forbes, Miriam K, Forbush, Kelsie T, Hengartner, Michael P, Ivanova, Masha Y, Leising, Daniel, Livesley, W John, Lukowitsky, Mark R, Lynam, Donald R, Markon, Kristian E, Miller, Joshua D, Morey, Leslie C, Mullins‐Sweatt, Stephanie N, Ormel, J Hans, Patrick, Christopher J, Pincus, Aaron L, Ruggero, Camilo, Samuel, Douglas B, Sellbom, Martin, Slade, Tim, Tackett, Jennifer L, Thomas, Katherine M, Trull, Timothy J, Vachon, David D, Waldman, Irwin D, Waszczuk, Monika A, Waugh, Mark H, Wright, Aidan GC, Yalch, Mathew M, Zald, David H, and Zimmermann, Johannes

Subjects
Biomedical and Clinical Sciences, Clinical and Health Psychology, Social and Personality Psychology, Clinical Sciences, Psychology, Humans, International Classification of Diseases, Personality Disorders, Public Health and Health Services, Clinical sciences, Clinical and health psychology, Social and personality psychology
Published
2018

15. Irritability in Youths: A Critical Integrative Review

Author

Leibenluft, Ellen, primary, Allen, Laura E., additional, Althoff, Robert R., additional, Brotman, Melissa A., additional, Burke, Jeffrey D., additional, Carlson, Gabrielle A., additional, Dickstein, Daniel P., additional, Dougherty, Lea R., additional, Evans, Spencer C., additional, Kircanski, Katharina, additional, Klein, Daniel N., additional, Malone, Eleanor P., additional, Mazefsky, Carla A., additional, Nigg, Joel, additional, Perlman, Susan B., additional, Pine, Daniel S., additional, Roy, Amy Krain, additional, Salum, Giovanni A., additional, Shakeshaft, Amy, additional, Silver, Jamilah, additional, Stoddard, Joel, additional, Thapar, Anita, additional, Tseng, Wan-Ling, additional, Vidal-Ribas, Pablo, additional, Wakschlag, Lauren S., additional, and Stringaris, Argyris, additional

Published
2024
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16. Editors’ Best of 2023

Author

Althoff, Robert R., primary, Bagot, Kara S., additional, Dickstein, Daniel P., additional, Drury, Stacy S., additional, Findling, Robert L., additional, and Singh, Manpreet K., additional

Published
2024
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20. Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders

Author

Rapp, Dr. Michael, Artiges, Dr. Eric, Schneider, Sophia, Bach, Christine, Paus, Dr. Tomas, Barbot, Alexis, Barker, Dr. Gareth, Bokde, Dr. Arun, Vetter, Dr. Nora, Büchel, Dr. Christian, Cattrell, Dr. Anna, Constant, Patrick, Gowland, Penny, Crombag, Dr. Hans, Czech, Katharina, Dalley, Dr. Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Dr. Tamzin, Heym, Dr. Nadja, Flor, Herta, Sommer, Dr. Wolfgang, Fuchs, Birgit, Gallinat, Dr. Jürgen, Garavan, Dr. Hugh, Spanagel, Dr. Rainer, Kaviani, Mehri, Heinrichs, Dr. Bert, Heinz, Dr. Andreas, Subramaniam, Naresh, Jia, Dr. Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Dr. Bernd, Conrod, Dr. Patricia, Banaschewski, Dr. Tobias, Jones, Jennifer, Klaassen, Dr. Arno, Lalanne, Christophe, Lanzerath, Dr. Dirk, Lawrence, Dr. Claire, Lemaitre, Dr. Hervé, Desrivieres, Dr. Sylvane, Mallik, Catherine, Mann, Dr. Karl, Mar, Dr. Adam, Martinez-Medina, Lourdes, Martinot, Dr. Jean-Luc, Mennigen, Eva, Mesquita de Carvahlo, Dr. Fabiana, Schwartz, Yannick, Bruehl, Dr. Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Dr. Mark, Robbins, Dr. Trevor, Pausova, Dr. Zdenka, Pentilla, Dr. Jani, Biondo, Dr. Francesca, Poline, Dr. Jean-Baptiste, Poustka, Dr. Luise, Millenet, Sabina, Smolka, Dr. Michael, Fröhner, Juliane, Struve, Dr. Maren, Williams, Dr. Steve, Hübner, Dr. Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Dr. Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Dr. Mercedes, Schubert, Dr. Florian, Pena-Oliver, Dr. Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Dr. Robert, Speiser, Dr. Claudia, Fadai, Tahmine, Stephens, Dr. Dai, Ströhle, Dr. Andreas, Paillere, Dr. Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Dr. Helene, Miranda, Ruben, Yacubilin, Dr. Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, Weiss, Katharina, Walter, Dr. Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Dr. Barbara, Xu, Bing, Macare, Christine, Chu, Dr. Congying, Hanratty, Eanna, Burke Quinlan, Dr. Erin, Robert, Dr. Gabriel, Schumann, Dr. Gunter, Yu, Dr. Tao, Ziesch, Veronika, Stedman, Alicia, Chaarani, Bader, Kan, Kees-Jan, Mackey, Scott, Spechler, Philip A., Potter, Alexandra, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Gallinat, Jürgen, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Stringaris, Argyris, Higgins, Stephen T., Schumann, Gunter, Garavan, Hugh, and Althoff, Robert R.

Published
2020
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23. Editors’ Best of 2023

Author

Novins, Douglas K., primary, Althoff, Robert R., additional, Brotman, Melissa A., additional, DelBello, Melissa P., additional, Doyle, Alysa E., additional, Fortuna, Lisa R., additional, Fristad, Mary A., additional, Middeldorp, Christel M., additional, Njoroge, Wanjikũ F.M., additional, Rogers, Cynthia E., additional, and Singh, Manpreet Kaur, additional

Published
2024
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26. Editors’ Note: Third Annual Report Regarding JAACAP’s Antiracist Journey

Author

Novins, Douglas K., primary, Singh, Manpreet K., additional, Althoff, Robert R., additional, Bagot, Kara S., additional, Brotman, Melissa A., additional, DelBello, Melissa P., additional, Dickstein, Daniel P., additional, Doyle, Alysa E., additional, Drury, Stacy S., additional, Findling, Robert L., additional, Fortuna, Lisa R., additional, Fristad, Mary A., additional, Middeldorp, Christel M., additional, Njoroge, Wanjikũ F.M., additional, Rogers, Cynthia E., additional, Pumariega, Andrés J., additional, Bath, Eraka, additional, Tobón, Amalia Londoño, additional, Thompson-Felix, Tara, additional, and Billingsley, Mary K., additional

Published
2023
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28. Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

Author

Banaschewski, Tobias, Barker, Gareth, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Artiges, Eric, Lemaitre, Herve, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Vetter, Nora C., Jurk, Sarah, Mennigen, Eva, Walter, Henrik, Whelan, Robert, Schumann, Gunter, Spechler, Philip A., Chaarani, Bader, Orr, Catherine, Mackey, Scott, Higgins, Stephen T., Conrod, Patricia J., Fröhner, Juliane H., and Althoff, Robert R.

Published
2019
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30. Brief Report: Me, Reporting on Myself: Preliminary Evaluation of the Criterion-Related Validity of the Theory of Mind Inventory-2 when Completed by Autistic Young Adults

Author

Crehan, Eileen T., Althoff, Robert R., Riehl, Hannah, Prelock, Patricia A., and Hutchins, Tiffany

Subjects
Young adults -- Psychological aspects -- Social aspects, Theory of mind -- Evaluation, Health
Abstract

There is a need for increased understanding of self-report measures for autistic individuals. In this preliminary study, we examine how a theory of mind self-report relates to other self-report measures for groups of autistic and neurotypical individuals, as well as eye tracking outcomes. Expected patterns of relatedness emerged between self-reports and the eye tracking findings, which lends validity to the theory of mind measure. Self-report measures are critical for autistic individuals to share their own experiences and this is the first step in establishing a theory of mind self-report tool., Author(s): Eileen T. Crehan [sup.1] , Robert R. Althoff [sup.2] , Hannah Riehl [sup.1] , Patricia A. Prelock [sup.3] , Tiffany Hutchins [sup.3] Author Affiliations: (1) grid.429997.8, 0000 0004 1936 [...]

Published
2020
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31. Low Smoking Exposure, the Adolescent Brain, and the Modulating Role of CHRNA5 Polymorphisms

Author

Mann, Karl, Struve, Maren, Rietschel, Marcella, Spanagel, Rainer, Fauth-Bühler, Mira, Millenet, Sabina, Grimmer, Yvonne, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Bricaud, Zuleima, Briand, Fanny Gollier, Lemaitre, Hervé, Massicotte, Jessica, Vulser, Helene, Pentillä, Jani, Galinowski, André, Jia, Tianye, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Stueber, Kerstin, Stringaris, Argyris, Constant, Patrick, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Rodehacke, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Jones, Jennifer, Poline, Jean-Baptiste, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Pausova, Zdenka, Tahmasebi, Amir, Chaarani, Bader, Kan, Kees-Jan, Mackey, Scott, Spechler, Philip A., Potter, Alexandra, Orr, Catherine, D’Alberto, Nicholas, Hudson, Kelsey E., Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Higgins, Stephen T., Schumann, Gunter, Althoff, Robert R., Stein, Elliot A., and Garavan, Hugh

Published
2019
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32. Future Directions: The Phenomenology of Irritable Mood and Outbursts: Hang Together or Hang Separately.

Author

Carlson, Gabrielle A., Althoff, Robert R., and Singh, Manpreet Kaur

Subjects
*PHENOMENOLOGY, *MEASURING instruments
Abstract

Recognition of the importance of irritable mood and outbursts has been increasing over the past several decades. This “Future Directions” aims to develop a set of recommendations for future research emphasizing that irritable mood and outbursts “hang together,” but have important distinctions and thus also need to “hang separately.” Outbursts that are the outcome of irritable mood may be quite different from outbursts that are the trigger or driving force that make youth and his/her environment miserable. What, then, is the relation between irritable mood and outbursts? As the field currently stands, we not only cannot answer this question, but we may also lack the tools to effectively do so. Here, we will propose recommendations for understanding the phenomenology of irritable mood and outbursts so that more directed and clinically useful assessment tools can be designed. We discuss the transdiagnostic and treatment implications that relate to improvements in measurement. We describe the need to do more than repurpose our current assessment tools, specifically interviews and rating scales, which were designed for different purposes. The future directions of the study and treatment of irritable mood and outbursts will require, among others, using universally accepted nomenclature, supporting the development of tools to measure the characteristics of each irritable mood and outbursts, understanding the effects of question order, informant, development and longitudinal course, and studying the ways in which outbursts and irritable mood respond to treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Our Hopes for JAACAP Open

Author

Singh, Manpreet K., primary, Althoff, Robert R., additional, Bagot, Kara S., additional, Dickstein, Daniel P., additional, Drury, Stacy S., additional, Findling, Robert L., additional, Billingsley, Mary K., additional, and Novins, Douglas K., additional

Published
2023
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40. List of Contributors

Author

Abdu-Glass, Eliza, primary, Althoff, Robert R., additional, Becker, Jessica E., additional, Beresin, Eugene V., additional, Bostic, Jeff Q., additional, Cavazos-Rehg, Patricia A., additional, Chaudhary, Neha P., additional, Echevarria, Ruben, additional, Evans, Jabari, additional, Feldmeier, Michael, additional, Ferguson, Christopher J., additional, Fortuna, Lisa, additional, Fremont, Wanda P., additional, Hightower, Brianna, additional, Hudziak, James J., additional, Judge, Abigail M., additional, Krinsky, Sylvia J., additional, Kutner, Lawrence A., additional, Lauricella, Alexis R., additional, Lisotto, Maria Jose, additional, Lovato, Silvia B., additional, Martin, Ardis C., additional, Olson, Cheryl K., additional, Optican, Allison, additional, Parekh, Ranna, additional, Pataki, Caroly, additional, Peek, Holly S., additional, Piacentini, Eric, additional, Pila, Sarah, additional, Powell, Paulina, additional, Rettew, David C., additional, Rubin, David H., additional, Sargent, John, additional, Schlozman, Steven C., additional, Smith, Sven, additional, Sossong, Anthony D., additional, Szeftel, Roxy, additional, Tabor-Furmark, Kara Sydelle, additional, Vallejos, Elvira Perez, additional, Wartella, Ellen A., additional, and Zhrebker, Liora, additional

Published
2019
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44. Editors’ Best of 2022

Author

Novins, Douglas K., primary, Althoff, Robert R., additional, Brotman, Melissa A., additional, Cortese, Samuele, additional, DelBello, Melissa, additional, Doyle, Alysa, additional, Drury, Stacy S., additional, Fortuna, Lisa, additional, Frazier, Jean A., additional, Fristad, Mary, additional, Henderson, Schuyler W., additional, McCauley, Elizabeth, additional, Middeldorp, Christel, additional, Njoroge, Wanjikũ F.M., additional, Rogers, Cynthia E., additional, and White, Tonya, additional

Published
2023
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46. Editors’ Note: Second Annual Report Regarding JAACAP’s Antiracist Journey

Author

Novins, Douglas K., primary, Althoff, Robert R., additional, Cortese, Samuele, additional, Drury, Stacy S., additional, Frazier, Jean A., additional, Henderson, Schuyler W., additional, McCauley, Elizabeth, additional, Njoroge, Wanjikũ F.M., additional, Singh, Manpreet Kaur, additional, White, Tonya, additional, Bath, Eraka, additional, and Billingsley, Mary K., additional

Published
2022
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48. Candidate Gene Associations with Withdrawn Behavior

Author

Rubin, David H., Althoff, Robert R., Ehli, Erik A., Davies, Gareth E., Rettew, David C., Crehan, Eileen T., Walkup, John T., and Hudziak, James J.

Abstract

Background: Social withdrawal is a core neuropsychiatric phenomenon in developmental psychopathology. Its presence predicts psychopathology across many domains, including depression, psychosis, autism, anxiety, and suicide. Withdrawn behavior is highly heritable, persistent, and characteristically worsens without intervention. To date, few studies have successfully identified genetic associations with withdrawn behavior, despite the abundance of evidence of its heritability. This may be due to reliance of categorical over dimensional measures of the behaviorally inhibited phenotype. The aim of this study is to identify associations between known psychiatric candidate genes and a dimensionally derived measure of withdrawn behavior. Methods: Genetic information was collected on 20 single-nucleotide polymorphisms (SNPs) from a custom-designed SNP chip and TAQMAN arrays of 4 variable number of tandem repeat (VNTR) genes for 551 individuals from 187 families. Linear mixed modeling was employed to examine the relationship between genotypes of interest and Child Behavior Checklist (CBCL) Withdrawn Behavior Subscale Score (WBS) while controlling for gender and age through multiple linear regressions. Results: Withdrawn behavior was highly associated with polymorphism "rs6314" of the serotonin receptor 2A ("HTR2A") [p = 0.009, estimate = 0.310 (bootstrap 95% CI 0.155-0.448), bootstrap p = 0.001] and "rs1800544" of the alpha 2-adrenergic ("ADRA2A") [ p = 0.001, estimate = -0.310 (bootstrap 95% CI -0.479 to -0.126), bootstrap p = 0.001] genes after correction for gender and age. The association between withdrawn behavior and "ADRA2A" was stronger for younger children. Conclusions: "HTR2A" and "ADRA2A" genes are associated with withdrawn behavior. This reinforces the role of catecholaminergic genes in the heritability of withdrawn behavior.

Published
2013
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