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Your search keyword '"Althafar, Ziyad M."' showing total 15 results
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15 results on '"Althafar, Ziyad M."'

7. Gramine Exerts Cytoprotective Effects and Antioxidant Properties Against H2O2-Induced Oxidative Stress in HEK 293 Cells.

Author

Sabi, Essa M., AlAfaleq, Nouf O., Mujamammi, Ahmed H, Al-Shouli, Samia T., Althafar, Ziyad M., Bin Dahman, Lotfi S., and Sumaily, Khalid M.

Abstract

Oxidative stress caused due to the perturbations in the oxidant-antioxidant system can damage molecules and cause cellular alteration leading to the pathogenesis of multiple diseases. This study was designed and performed to investigate the antioxidant and anti-inflammatory effects of an alkaloid, gramine on H2O2-induced oxidative stress on HEK 293 cells. Cell viability and morphometric analysis of cells treated with H2O2 and gramine were studied. Oxidative stress and inflammatory and antioxidant enzymes such as ROS, LPO, NO, SOD, GSH, and CAT were analyzed. Furthermore, mRNA expression of SOD, CAT, and COX-2 was also evaluated. H2O2 at concentration > 0.3 mM and gramine at concentration > 80 μg/mL affect the proliferation. Viability and morphometric analysis showed that gramine has protective effects. Treating cells with gramine suppressed oxidative stress and inflammatory enzymes, whereas antioxidant enzymes were enhanced. SOD and CAT mRNA levels were overexpressed and COX-2 mRNA levels were decreased in the treated groups. Gramine possesses effective antioxidant potential and can regulate oxidative stress and damages associated with it. [ABSTRACT FROM AUTHOR]

Published
2024
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14. 10-Dehydrogingerdione Attenuates Tramadol-Induced Nephrotoxicity by Modulating Renal Oxidative Stress, Inflammation and Apoptosis in Experimental Rats: Role of HO-1 Activation and TLR4/NF-κB/ERK Inhibition

Author

Elnagar, Gehad M., primary, Elseweidy, Mohamed M., additional, Mahmoud, Yasmin K., additional, Elkomy, Nesreen M. I. M., additional, Althafar, Ziyad M., additional, Alnomasy, Sultan F., additional, Al-Gabri, Naif A., additional, and Shawky, Mohamed, additional

Published
2022
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15. Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats

Author

Al-Gabri, Naif, primary, Elnagar, Gehad M., additional, Saghir, Sultan A. M., additional, El-Shaibany, Amina, additional, Alnomasy, Sultan F., additional, Althafar, Ziyad M., additional, Elkomy, Nesreen M. I. M., additional, Elaasser, Mahmoud M., additional, Abdoh, Maisa Siddiq, additional, and Yosri, Mohammed, additional

Published
2022
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