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12. The Significance of Hematuria in Podocytopathies

Author

Marchel, Dorota, Trachtman, Howard, Larkina, Maria, Helmuth, Margaret, Lai Yee, Jennifer Y., Fermin, Damian, Bomback, Andrew S., Canetta, Pietro A., Gipson, Debbie S., Mottl, Amy K., Parekh, Rulan S., Saha, Manish K., Sampson, Matthew G., Lafayette, Richard A., Mariani, Laura H., Massengill, S., Lo, L., Dell, K., Sedor, J., Martin, B., Lemley, K., Fajardo, C., Sharma, S., Srivastava, T., Markus, K., Sethna, C., Vento, S., Canetta, P., Pradhan, A., Gbadegesin, R., Olabisi, O., Smith, M., Greenbaum, L., Wang, C.S., Yun, E., Adler, S., LaPage, J., Amarah, A., Itteera, M., Atkinson, M., Williams, M., Fervenza, F., Hogan, M., Lieske, J., Selewski, D., Alston, C., Kaskel, F., Ross, M., Flynn, P., Kopp, J., Malaga-Dieguez, L., Zhdanova, O., Pehrson, L.J., Almaani, S., Roberts, L., Lafayette, R., Dave, S., Lee, I., Pfeffer, Z., Shah, S., Deslandes, A., Reich, H., Hladunewich, M., Ling, P., Romano, M., Brakeman, P, Podoll, A., Rogers, N., McCarthy, E., Landry, E., Fornoni, A., Bidot, C., Kretzler, M., Gipson, D., Williams, A., Stelzer, M., Nachman, P., Rheault, M., Rao, V., Derebail, V., Gibson, K., Froment, A., Ochoa-Toro, F., Holzman, L., Meyers, K., Kallem, K., Swenson, A., Sharma, K., Sambandam, K., Robles, E., Turk, M., Jefferson, A., Hingorani, S., Tuttle, K., Manahan, L., Pao, E., Kuykendall K, K., Lin, J.J., Cody, E., Kretzler, M., Barisoni, L., Gadegbeku, C., Gillespie, B., Gipson, D., Holzman, L., Mariani, L., Sampson, M.G., Sedor, J., Smith, A., Zee, J., Alter, G., Desmond, H., Eddy, S., Fermin, D., Ju, W., Larkina, M., Li, S., Lienczewski, C.C., Mainieri, T., Scherr, R., Troost, J., Williams, A., Wang, Y., Avila-Casado, Carmen, Bagnasco, Serena, Cassol, Clarissa, Bu, Lihong, Caltharp, Shelley, Demeke, Dawit, Gillespie, Brenda, Hassler, Jared, Herlitz, Leal, Hewitt, Stephen, Hodgin, Jeff, Holanda, Danni, Kambham, Neeraja, Lemley, Kevin, Mariani, Laura, Messias, Nidia, Mikhailov, Alexei, Najafian, Behzad, Palmer, Matthew, Rosenberg, Avi, Royal, Virginie, Stokes, Barry, Thomas, David, Yamashita, Michifumi, Yin, Hong, Zee, Jarcy, Zuo, Yiqin, Barisoni, Laura, Nast, Cynthia, Ahn, Wooin, Appel, Gerald, Appelbaum, Paul, Babayev, Revekka, Bomback, Andrew, Canetta, Pietro, Chan, Brenda, DʼAgati, Vivette Denise, Dogra, Samitri, Fernandez, Hilda, Gharavi, Ali, Hines, William, Husain, Syed Ali, Jain, Namrata, Kiryluk, Krzysztof, Lin, Fangming, Marasa, Maddalena, Markowitz, Glen, Rasouly, Hila Milo, Mohan, Sumit, Mongera, Nicola, Nestor, Jordan, Nickolas, Thomas, Radhakrishnan, Jai, Rao, Maya, Sanna-Cherchi, Simone, Shirazian, Shayan, Stokes, Michael Barry, Uy, Natalie, Valeri, Anthony, Vena, Natalie, Foroncewicz, Bartosz, Moszczuk, Barbara, Mucha, Krzysztof, Perkowska-Ptasińska, Agnieszka, Ghiggeri, Gian Marco, Lugani, Francesca, Ambruzs, Josephine, Liapis, Helen, Baracco, Rossana, Jain, Amrish, Ashoor, Isa, Aviles, Diego, Srivastava, Tarak, Ahn, Sun-Young, Devarajan, Prasad, Erkan, Elif, Claes, Donna, Stone, Hillarey, Mason, Sherene, Gbadegesin, Rasheed, Gomez-Mendez, Liliana, Greenbaum, Larry, Wang, Chia-shi, Yin, Hong (Julie), Cai, Yi, Jens, Goebel, Steinke, Julia, Weaver, Donald, Lane, Jerome, Cramer, Carl, Pan, Cindy, Paloian, Neil, Sreedharan, Rajasree, Selewski, David, Twombley, Katherine, Bowers, Corinna, Dreher, Mary, Kallash, Mahmoud, Mahan, John, Sharpe, Samantha, Smoyer, William, Al-Uzri, Amira, Iragorri, Sandra, Khalid, Myda, Belsha, Craig, Alge, Joseph, Braun, Michael, Gomez, AC, Wenderfer, Scott, Vasylyeva, Tetyana, Feig, Daniel, Fuentes, Gabriel Cara, Hannah, Melisha, Nester, Carla, Chishti, Aftab, Klein, Jon, Katsoufis, Chryso, Seeherunvong, Wacharee, Rheault, Michelle, Wong, Craig, Mathews, Nisha, Barcia, John, Swiatecka-Urban, Agnes, Bartosh, Sharon, Hunley, Tracy, Dharnidharka, Vikas, Gaut, Joseph, Laurin, Louis-Philippe, Royal, Virginie, Achanti, Anand, Budisavljevic, Milos, Self, Sally, Ghossein, Cybele, Peleg, Yonatan, Wadhwani, Shikha, Almaani, Salem, Ayoub, Isabelle, Nadasdy, Tibor, Samir, Parikh, Rovin, Brad, Chang, Anthony, Fatima, Huma, Julian, Bruce, Novak, Jan, Renfrow, Matthew, Rizk, Dana, Chen, Dhruti, Derebail, Vimal, Falk, Ronald, Gibson, Keisha, Glenn, Dorey, Hogan, Susan, Jain, Koyal, Jennette, J. Charles, Mottl, Amy, Poulton, Caroline, Saha, Manish Kanti, Fogo, Agnes, Sanghani, Neil, Kidd, Jason, Muthusamy, Selvaraj, Schelling, Jeffrey, Hou, Jean, Lemley, Kevin, Mika, Warren, Russo, Pierre, Denburg, Michelle, Kogon, Amy, Meyers, Kevin, Pradhan, Madhura, Matar, Raed Bou, OʼToole, John, Sedor, John, Sethna, Christine, Vento, Suzanne, Atta, Mohamed, Bagnasco, Serena, Neu, Alicia, Sperati, John, Adler, Sharon, Dai, Tiane, Dukkipati, Ram, Fervenza, Fernando, Sethi, Sanjeev, Kaskel, Frederick, Brathwaite, Kaye, Reidy, Kimberly, Weisstuch, Joseph, Wu, Ming, Zhdanova, Olga, Heymann, Jurgen, Kopp, Jeffrey, Waldman, Meryl, Winkler, Cheryl, Tuttle, Katherine, Krissberg, Jill, Lafayette, Richard, Fahmeedah, Kamal, Talley, Elizabeth, Hladunewich, Michelle, Parekh, Rulan, Avila-Casado, Carmen, Cattran, Daniel, Heather, Reich, Boll, Philip, Drexler, Yelena, Fornoni, Alessia, Gipson, Patrick, Hodgin, Jeffrey, Oliverio, Andrea, Hogan, Jon, Holzman, Lawrence, Palmer, Matthew, Coppock, Gaia, Abromovitz, Blaise, Mortiz, Michael, Alpers, Charles, Jefferson, J. Ashley, Brown, Elizabeth, Sambandam, Kamal, Roehm, Bethany, Smith, Abigail, Nast, Cynthia, Barisoni, Laura, Gillespie, Brenda, Robinson, Bruce, Kretzler, Matthias, Mariani, Laura, and Guay-Woodford, Lisa M.

Published
2024
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13. Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

Author

Collier, A.Y., McMahan, K., Yu, J., Tostanoski, L.H., Aguayo, R., Ansel, J., Chandrashekar, A., Patel, S., Apraku Bondzie, E., Sellers, D., Barrett, J., Sanborn, O., Wan, H., Chang, A., Anioke, T., Nkolola, J., Bradshaw, C., Jacob-Dolan, C., Feldman, J., Gebre, M., Borducchi, E.N., Liu, J., Schmidt, A.G., Suscovich, T., Linde, C., Alter, G., Hacker, M.R., and Barouch, D.H.

Published
2022
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14. Promoting an open research culture

Author

Nosek, BA, Alter, G, Banks, GC, Borsboom, D, Bowman, SD, Breckler, SJ, Buck, S, Chambers, CD, Chin, G, Christensen, G, Contestabile, M, Dafoe, A, Eich, E, Freese, J, Glennerster, R, Goroff, D, Green, DP, Hesse, B, Humphreys, M, Ishiyama, J, Karlan, D, Kraut, A, Lupia, A, Mabry, P, Madon, TA, Malhotra, N, Mayo-Wilson, E, McNutt, M, Miguel, E, Paluck, E Levy, Simonsohn, U, Soderberg, C, Spellman, BA, Turitto, J, VandenBos, G, Vazire, S, Wagenmakers, EJ, Wilson, R, and Yarkoni, T

Subjects
Information and Computing Sciences, Education, Library and Information Studies, Access to Information, Disclosure, Guidelines as Topic, Peer Review, Research, Periodicals as Topic, Reproducibility of Results, Research, General Science & Technology
Abstract

Author guidelines for journals could help to promote transparency, openness, and reproducibility

Published
2015

15. A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced Fc RIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques

Author

Moldt, B., Shibata-Koyama, M., Rakasz, E. G, Schultz, N., Kanda, Y., Dunlop, D. C, Finstad, S. L, Jin, C., Landucci, G., Alpert, M. D, Dugast, A.-S., Parren, P. W. H. I, Nimmerjahn, F., Evans, D. T, Alter, G., Forthal, D. N, Schmitz, J. E, Iida, S., Poignard, P., Watkins, D. I, Hessell, A. J, and Burton, D. R

Subjects
Animals, Antibodies, Monoclonal/*administration & dosage/immunology/isolation & purification/metabolism, Cells, Cultured, Female, HIV Antibodies/*administration & dosage/immunology/isolation & purification/metabolism, HIV-1/*immunology, Humans, Macaca mulatta, Receptors, IgG/*immunology/metabolism, Simian Acquired Immunodeficiency Syndrome/pathology/*prevention & control/virology, Simian Immunodeficiency Virus/*immunology/pathogenicity, Viral Load
Abstract

Eliciting neutralizing antibodies is thought to be a key activity of a vaccine against human immunodeficiency virus (HIV). However, a number of studies have suggested that in addition to neutralization, interaction of IgG with Fc gamma receptors (FcγR) may play an important role in antibody-mediated protection. We have previously obtained evidence that the protective activity of the broadly neutralizing human IgG1 anti-HIV monoclonal antibody (MAb) b12 in macaques is diminished in the absence of FcγR binding capacity. To investigate antibody-dependent cellular cytotoxicity (ADCC) as a contributor to FcγR-associated protection, we developed a nonfucosylated variant of b12 (NFb12). We showed that, compared to fully fucosylated (referred to as wild-type in the text) b12, NFb12 had higher affinity for human and rhesus macaque FcγRIIIa and was more efficient in inhibiting viral replication and more effective in killing HIV-infected cells in an ADCC assay. Despite these more potent in vitro antiviral activities, NFb12 did not enhance protection in vivo against repeated low-dose vaginal challenge in the simian-human immunodeficiency virus (SHIV)/macaque model compared to wild-type b12. No difference in protection, viral load, or infection susceptibility was observed between animals given NFb12 and those given fully fucosylated b12, indicating that FcγR-mediated activities distinct from FcγRIIIa-mediated ADCC may be important in the observed protection against SHIV challenge.

Published
2012

16. Altered distribution of mucosal NK cells during HIV infection.

Author

Sips, M, Sciaranghella, G, Diefenbach, T, Dugast, A-S, Berger, CT, Liu, Q, Kwon, D, Ghebremichael, M, Estes, JD, Carrington, M, Martin, JN, Deeks, SG, Hunt, PW, and Alter, G

Subjects
Intestinal Mucosa, Killer Cells, Natural, Lymphocyte Subsets, Humans, HIV, HIV Infections, HLA Antigens, Biopsy, Antiretroviral Therapy, Highly Active, DNA Mutational Analysis, Cell Movement, Genotype, Polymorphism, Genetic, Biomarkers, Pharmacological, Receptors, KIR, Killer Cells, Natural, Antiretroviral Therapy, Highly Active, Polymorphism, Genetic, Biomarkers, Pharmacological, Receptors, KIR, Immunology, Biological Sciences, Medical and Health Sciences
Abstract

The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s) by which they mediate antiviral activity in the gut is unclear. Here, we show that two distinct subsets of NK cells exist in the gut, one localized to intraepithelial spaces (intraepithelial lymphocytes, IELs) and the other to the lamina propria (LP). The frequency of both subsets of NK cells was reduced in chronic infection, whereas IEL NK cells remained stable in spontaneous controllers with protective killer immunoglobulin-like receptor/human leukocyte antigen genotypes. Both IEL and LP NK cells were significantly expanded in immunological non-responsive patients, who incompletely recovered CD4+ T cells on highly active antiretroviral therapy (HAART). These data suggest that both IEL and LP NK cells may expand in the gut in an effort to compensate for compromised CD4+ T-cell recovery, but that only IEL NK cells may be involved in providing durable control of HIV in the gut.

Published
2012

17. Waning and boosting of functional humoral immunity to SARS-CoV-2

Author

Tong, X., primary, McNamara, R.P., additional, Avendaño, M.J., additional, Serrano, E.F., additional, García-Salum, T., additional, Pardo-Roa, C., additional, Levican, J., additional, Poblete, E., additional, Salina, E., additional, Muñoz, A., additional, Riquelme, A., additional, Alter, G., additional, and Medina, R.A., additional

Published
2022
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18. Defining discriminatory antibody fingerprints in active and latent tuberculosis

Author

Nziza, N., Cizmeci, D., Davies, L., Irvine, E.B., Jung, W.Y., Fenderson, B.A., Kock, M. de, Hanekom, W.A., Franken, K.L.M.C., Day, C.L., Ottenhoff, T.H.M., and Alter, G.

Subjects
active and latent tuberculosis, Latent Tuberculosis, Immunology, diagnostics, Immunology and Allergy, COVID-19, Humans, Tuberculosis, antibodies, HIV, biomarkers, HIV Infections
Abstract

Tuberculosis (TB) is among the leading causes of death worldwide from a single infectious agent, second only to COVID-19 in 2020. TB is caused by infection with Mycobacterium tuberculosis (Mtb), that results either in a latent or active form of disease, the latter associated with Mtb spread. In the absence of an effective vaccine, epidemiologic modeling suggests that aggressive treatment of individuals with active TB (ATB) may curb spread. Yet, clinical discrimination between latent (LTB) and ATB remains a challenge. While antibodies are widely used to diagnose many infections, the utility of antibody-based tests to diagnose ATB has only regained significant traction recently. Specifically, recent interest in the humoral immune response to TB has pointed to potential differences in both targeted antigens and antibody features that can discriminate latent and active TB. Here we aimed to integrate these observations and broadly profile the humoral immune response across individuals with LTB or ATB, with and without HIV co-infection, to define the most discriminatory humoral properties and diagnose TB disease more easily. Using 209 Mtb antigens, striking differences in antigen-recognition were observed across latently and actively infected individuals that was modulated by HIV serostatus. However, ATB and LTB could be discriminated, irrespective of HIV-status, based on a combination of both antibody levels and Fc receptor-binding characteristics targeting both well characterized (like lipoarabinomannan, 38 kDa or antigen 85) but also novel Mtb antigens (including Rv1792, Rv1528, Rv2435C or Rv1508). These data reveal new Mtb-specific immunologic markers that can improve the classification of ATB versus LTB.

Published
2022

19. Delayed booster dosing improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine

Author

Nielsen, CM, primary, Barrett, JR, additional, Davis, C, additional, Fallon, JK, additional, Goh, C, additional, Michell, AR, additional, Griffin, C, additional, Kwok, A, additional, Loos, C, additional, Darko, S, additional, Laboune, F, additional, Silk, SE, additional, Tekman, M, additional, Francica, JR, additional, Ransier, A, additional, Payne, RO, additional, Minassian, AM, additional, Lauffenburger, DA, additional, Seder, RA, additional, Douek, DC, additional, Alter, G, additional, and Draper, SJ, additional

Published
2022
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21. Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis

Author

Zee, Jarcy, Liu, Qian, Smith, Abigail R., Hodgin, Jeffrey B., Rosenberg, Avi, Gillespie, Brenda W., Holzman, Lawrence B., Barisoni, Laura, Mariani, Laura H., Adler, S., Alter, G., Athavale, A., Atkinson, M., Avila-Casado, C., Bagnasco, S., Baker, S., Barisoni, L., Bidot, C., Blake, J., Bray, M., Canetta, P., Chernitskiy, V., Cooper, A., Dell, K., Dell, T., Derebail, V., Desmond, H., Eddy, S., Fermin, D., Fervenza, F., Flynn, P., Fornoni, A., Froment, A., Gadegbeku, C., Gaut, J., Gibson, K., Gillespie, B., Gipson, D., Greenbaum, L., Hewitt, S., Hingorani, S., Hladunewich, M., Hodgin, J., Hogan, M., Holzman, L., Itteera, M., Jefferson, A., Kallem, K., Kaskel, F., Klida, C., Kretzler, M., Kopp, J., Kretzler, M., Kurtz, V., Lafayette, R., LaPage, J., Larkina, M., Lemley, K., Lieske, J., Li, S., Li, S., Lienczewski, C.C., Lin, J.J., Ling, P., Liu, J., Mainieri, T., Mariani, L., Meyers, K., Modersitzki, F., Morrison, S., Nast, C., Negrey, J., Ormond-Foster, J., Palmer, M., Pao, E., Pfaiff, M., Pradhan, A., Romano, M., Rosenberg, A., Royal, V., Quinn-Boyle, S., Reich, H., Rogers, M., Ross, M., Sambandam, K., Sampson, M., Schachere, M., Sedor, J., Sethna, C., Srivastava, T., Smith, A., Swenson, A., Tang, S., Thomas, D., Trachtman, H., Tuttle, K., Vento, S., Wang, C., Wang, Z., Williams, A., Yeung, B., Yun, E., Zee, J., Zhdanova, O., Adler, S., Alter, G., Athavale, A., Atkinson, M., Avila-Casado, C., Bagnasco, S., Baker, S., Barisoni, L., Bidot, C., Blake, J., Bray, M., Canetta, P., Cassol, C., Chernitskiy, V., Cooper, A., Dell, K., Dell, T., Demeke, D., Derebail, V., Desmond, H., Eddy, S., Fermin, D., Fervenza, F., Flynn, P., Fornoni, A., Froment, A., Gadegbeku, C., Gaut, J., Gibson, K., Gillespie, B., Gipson, D., Greenbaum, L., Hewitt, S., Hingorani, S., Hladunewich, M., Hodgin, J., Hogan, M., Holanda, D., Holzman, L., Itteera, M., Jefferson, A., Kallem, K., Kaskel, F., Klida, C., Kopp, J., Kretzler, M., Kurtz, V., Lafayette, R., LaPage, J., Larkina, M., Lemley, K., Lieske, J., Li, S., Li, S., Lienczewski, C.C., Lin, J.J., Ling, P., Liu, J., Mainieri, T., Mariani, L., Messias, N., Meyers, K., Michailov, A., Modersitzki, F., Morrison, S., Nast, C., Negrey, J., Ormond-Foster, J., Palmer, M., Pao, E., Pfaiff, M., Pradhan, A., Romano, M., Rosenberg, A., Royal, V., Quinn-Boyle, S., Reich, H., Rogers, M., Ross, M., Sambandam, K., Sampson, M., Schachere, M., Sedor, J., Sethna, C., Srivastava, T., Smith, A., Swenson, A., Tang, S., Thomas, D., Trachtman, H., Tuttle, K., Vento, S., Wang, C., Wang, Z., Williams, A., Yamashita, M., Yeung, B., Yun, E., Zee, J., Zhdanova, O., and Zuo, Y.

Abstract

The classification of podocytopathies, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), has historically been based on limited glomerular features. This study used supervised machine learning methods to identify the most important clinical and histopathologic predictors of disease progression, complete proteinuria remission, and treatment response in MCD/FSGS. The top predictors included conventional and novel glomerular and tubulointerstitial features. Biopsy reporting for podocytopathies should be standardized by including these prognostic morphologic features to inform risk stratification.

Published
2022
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23. SCIENTIFIC STANDARDS: Promoting an open research culture: Author guidelines for journals could help to promote transparency, openness, and reproducibility

Author

Nosek, B. A., Alter, G., Banks, G. C., Borsboom, D., Bowman, S. D., Breckler, S. J., Buck, S., Chambers, C. D., Chin, G., Christensen, G., Contestabile, M., Dafoe, A., Eich, E., Freese, J., Glennerster, R., Goroff, D., Green, D. P., Hesse, B., Humphreys, M., Ishiyama, J., Karlan, D., Kraut, A., Lupia, A., Mabry, P., Madon, T. A., Malhotra, N., Mayo-Wilson, E., McNutt, M., Miguel, E., Paluck, E. Levy, Simonsohn, U., Soderberg, C., Spellman, B. A., Turitto, J., VandenBos, G., Vazire, S., Wagenmakers, E. J., Wilson, R., and Yarkoni, T.

Published
2015

27. International AIDS Society global scientific strategy: towards an HIV cure 2016

Author

Deeks, Sg, Lewin, Sr, Ross, Al, Ananworanich, J, Benkirane, M, Cannon, P, Chomont, N, Douek, D, Lifson, Jd, Lo, Yr, Kuritzkes, D, Margolis, D, Mellors, J, Persaud, D, Tucker, Jd, Barre-Sinoussi, F, International Aids Society Towards a Cure Working Group, International Aids Society Towards a Cure Working Group, Alter, G, Auerbach, J, Autran, B, Barouch, Dh, Behrens, G, Cavazzana, M, Chen, Z, Cohen, Ea, Corbelli, Gm, Eholié, S, Eyal, N, Fidier, S, Garcia, L, Grossman, C, Henderson, G, Henrich, Tj, Jefferys, R, Kiem, Hp, Mccune, J, Moodley, K, Newman, Pa, Nijhuis, M, Nsubuga, Ms, Ott, M, Palmer, S, Richman, D, Saez-Cirion, A, Sharp, M, Siliciano, J, Silvestri, G, Singh, J, Spire, B, Taylor, J, Tolstrup, M, Valente, S, van Lunzen, J, Walensky, R, Wilson, I, Zack, J, Department of Medicine [San Francisco], University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia, International and Scientific Relations Office, ANRS, Paris, France, Walter Reed Army Institute of Research, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Southern California (USC), Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), National Institutes of Health [Bethesda] (NIH), Frederick National Laboratory for Cancer Research (FNLCR), World Health Organization Regional Office for the Western Pacific, Manila, Philippines, Brigham and Women's Hospital [Boston], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Institut Pasteur [Paris] (IP), Ragon Institute of MGH, MIT and Harvard, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS), Clinic for Immunology and Rhematology, Hannover Medical School, Hanover, Germany, Département de Biothérapie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AIDS Institute, The University of Hong Kong, Pok Fu Lam, Hong Kong, Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal (UdeM), European AIDS Treatment Group, Italy, Programme PAC-CI, Centre Hospitalier Universitaire de Treichville, Abidjan, Côte d'Ivoire, Harvard School of Public Health, Imperial College London, The B-Change Group, Manila, Philippines, Treatment Action Group (TAG), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Stellenbosch University, Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada, University Medical Center [Utrecht], Joint Clinical Research Centre, University of California (UC), The Westmead Institute for Medical Research, University of California [San Diego] (UC San Diego), Independent HIV Education and Advocacy Consultant, San Francisco, California, USA, Emory University [Atlanta, GA], Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CARE Collaboratory Community Advisory Board, Palm Springs, California, USA., Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark., The Scripps Research Institute [La Jolla, San Diego], ViiV Healthcare, London, United Kingdom., Massachusetts General Hospital [Boston], Brown University School of Public Health, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California [San Francisco] (UCSF), University of California-University of California, Institut Pasteur [Paris], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5), Department of Medicine, Imperial College London, London, United Kingdom, University of California, Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Scripps Research Institute, Imperial College Healthcare NHS Trust- BRC Funding, American Foundation for AIDS Research, Medical Research Council (MRC), MRC DCS, British HIV Association (BHIVA), and Larose, Catherine

Subjects
CD4(+) T-CELLS, 0301 basic medicine, International Cooperation, [SDV]Life Sciences [q-bio], VIRAL RESERVOIR, Human immunodeficiency virus (HIV), Stakeholder engagement, HIV Infections, [SDV.GEN] Life Sciences [q-bio]/Genetics, Research & Experimental Medicine, medicine.disease_cause, Medicine, Societies, Medical, IN-VIVO, ComputingMilieux_MISCELLANEOUS, HIGHLY PATHOGENIC SIV, virus diseases, LATENT HIV-1, 11 Medical And Health Sciences, General Medicine, TREATMENT INTERRUPTION, 3. Good health, [SDV] Life Sciences [q-bio], International AIDS Society Towards a Cure Working Group, Medicine, Research & Experimental, Goals, Life Sciences & Biomedicine, BROADLY NEUTRALIZING ANTIBODIES, Biochemistry & Molecular Biology, medicine.medical_specialty, RALTEGRAVIR INTENSIFICATION, Immunology, education, Article, General Biochemistry, Genetics and Molecular Biology, HISTONE DEACETYLASE INHIBITOR, 03 medical and health sciences, Global population, Acquired immunodeficiency syndrome (AIDS), SUPPRESSIVE ANTIRETROVIRAL THERAPY, Journal Article, Humans, Organizational Objectives, Acquired Immunodeficiency Syndrome, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, business.industry, Research, Cell Biology, medicine.disease, Antiretroviral therapy, 030104 developmental biology, Treatment interruption, Family medicine, business
Abstract

Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.

Published
2016

28. Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection

Author

Scully, E.P., primary, Rutishauser, R.L., additional, Simoneau, C.R., additional, Delagrèverie, H., additional, Euler, Z., additional, Thanh, C., additional, Li, J.Z., additional, Hartig, H., additional, Bakkour, S., additional, Busch, M., additional, Alter, G., additional, Marty, F.M., additional, Wang, C -C, additional, Deeks, S.G., additional, Lorch, J., additional, and Henrich, T.J., additional

Published
2018
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29. Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein

Author

King, L.B., primary, Fusco, M.L., additional, Flyak, A.I., additional, Ilinykh, P.A., additional, Huang, K., additional, Gunn, B., additional, Kirchdoerfer, R.N., additional, Hastie, K.M., additional, Sangha, A.K., additional, Meiler, J., additional, Alter, G., additional, Bukreyev, A., additional, Crowe, J.E.J., additional, and Saphire, E.O., additional

Published
2018
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31. Program and abstracts for the 2011 Meeting of the Society for Glycobiology

Author

Hollingsworth, MT, Hart, GW, Paulson, JC, Stansell, E, Canis, K, Huang, IC, Panico, M, Morris, H, Haslam, S, Farzan, M, Dell, A, Desrosiers, R, von Itzstein, M, Matroscovich, M, Luther, KB, Hülsmeier, AJ, Schegg, B, Hennet, T, Nycholat, C, McBride, R, Ekiert, D, Xu, R, Peng, W, Razi, N, Gilbert, M, Wakarchuk, W, Wilson, IA, Gahlay, G, Geisler, C, Aumiller, JJ, Moremen, K, Steel, J, Labaer, J, Jarvis, DL, Drickamer, K, Taylor, M, Nizet, V, Rabinovich, G, Lewis, C, Cobb, B, Kawasaki, N, Rademacher, C, Chen, W, Vela, J, Maricic, I, Crocker, P, Kumar, V, Kronenberg, M, Paulson, J, Glenn, K, Mallinger, A, Wen, H, Srivastava, L, Tundup, S, Harn, D, Menon, AK, Yamaguchi, Y, Mkhikian, H, Grigorian, A, Li, C, Chen, HL, Newton, B, Zhou, RW, Beeton, C, Torossian, S, Tatarian, GG, Lee, SU, Lau, K, Walker, E, Siminovitch, KA, Chandy, KG, Yu, Z, Dennis, JW, Demetriou, M, Pandey, MS, Baggenstoss, BA, Washburn, JL, Weigel, PH, Chen, CI, Keusch, JJ, Klein, D, Hofsteenge, J, Gut, H, Szymanski, C, Feldman, M, Schaffer, C, Gao, Y, Strum, S, Liu, B, Schutzbach, JS, Druzhinina, TN, Utkina, NS, Torgov, VI, Szarek, WA, Wang, L, Brockhausen, I, Hitchen, P, Peyfoon, E, Meyer, B, Albers, SV, Chen, C, Newburg, DS, Jin, C, Dinglasan, RD, Beverley, SM, Guo, H, Novozhilova, N, Hickerson, S, Elnaiem, DE, Sacks, D, Turco, SJ, McKay, D, Castro, E, Takahashi, H, Straus, AH, Stalnaker, SH, Live, D, Boons, GJ, Wells, L, Stuart, R, Aoki, K, Boccuto, L, Zhang, Q, Wang, H, Bartel, F, Fan, X, Saul, R, Chaubey, A, Yang, X, Steet, R, Schwartz, C, Tiemeyer, M, Pierce, M, Kraushaar, DC, Condac, E, Nakato, H, Nishihara, S, Sasaki, N, Hirano, K, Nasirikenari, M, Collins, CC, Lau, JT, Devarapu, SK, Jeyaweerasinkam, S, Albiez, RS, Kiessling, L, Gu, J, Clark, GF, Gagneux, P, Ulm, C, Mahavadi, P, Müller, S, Rinné, S, Geyer, H, Gerardy-Schahn, R, Mühlenhoff, M, Günther, A, Geyer, R, Galuska, SP, Shibata, T, Sugihara, K, Nakayama, J, Fukuda, M, Fukuda, MN, Ishikawa, A, Terao, M, Kimura, A, Kato, A, Katayama, I, Taniguchi, N, Miyoshi, E, Aderem, A, Yoneyama, T, Angata, K, Bao, X, Chanda, S, Lowe, J, Sonon, R, Ishihara, M, Talabnin, K, Wang, Z, Black, I, Naran, R, Heiss, C, Azadi, P, Hurum, D, Rohrer, J, Balland, A, Valliere-Douglass, J, Kodama, P, Mujacic, M, Eakin, C, Brady, L, Wang, WC, Wallace, A, Treuheit, M, Reddy, P, Schuman, B, Fisher, S, Borisova, S, Coates, L, Langan, P, Evans, S, Yang, SJ, Zhang, H, Hizal, DB, Tian, Y, Sarkaria, V, Betenbaugh, M, Lütteke, T, Agravat, S, Cholleti, S, Morris, T, Saltz, J, Song, X, Cummings, R, Smith, D, Hofhine, T, Nishida, C, Mialy, R, Sophie, D, Sebastien, F, Patricia, C, Eric, S, Stephane, H, Mokros, D, Joosten, RP, Dominik, A, Vriend, G, Nguyen, LD, Martinez, J, Hinderlich, S, Reissig, HU, Reutter, W, Fan, H, Saenger, W, Moniot, S, Asada, H, Nakahara, T, Miura, Y, Stevenson, T, Yamazaki, T, De Castro, C, Burr, T, Lanzetta, R, Molinaro, A, Parrilli, M, Sule, S, Gerken, TA, Revpredo, L, Thome, J, Cardenas, G, Almeida, I, Leung, MY, Yan, S, Paschinger, K, Bleuler-Martinez, S, Jantsch, V, Wilson, I, Yoshimura, Y, Adlercreutz, D, Mannerstedt, K, Wakarchuk, WW, Dovichi, NJ, Hindsgaul, O, Palcic, MM, Chandrasekaran, A, Bharadwaj, R, Deng, K, Adams, P, Singh, A, Datta, A, Konasani, V, Imamura, A, Lowry, T, Scaman, C, Zhao, Y, Zhou, YD, Yang, K, Zhang, XL, Leymarie, N, Hartshorn, K, White, M, Cafarella, T, Seaton, B, Rynkiewicz, M, Zaia, J, Acosta-Blanco, I, Ortega-Francisco, S, Dionisio-Vicuña, M, Hernandez-Flores, M, Fuentes-Romero, L, Newburg, D, Soto-Ramirez, LE, Ruiz-Palacios, G, Viveros-Rogel, M, Tong, C, Li, W, Kong, L, Qu, M, Jin, Q, Lukyanov, P, Zhang, W, Chicalovets, I, Molchanova, V, Wu, AM, Liu, JH, Yang, WH, Nussbaum, C, Grewal, PK, Sperandio, M, Marth, JD, Yu, R, Usuki, S, Wu, HC, O'Brien, D, Piskarev, V, Ramadugu, SK, Kashyap, HK, Ghirlanda, G, Margulis, C, Brewer, C, Gomery, K, Müller-Loennies, S, Brooks, CL, Brade, L, Kosma, P, Di Padova, F, Brade, H, Evans, SV, Asakawa, K, Kawakami, K, Kushi, Y, Suzuki, Y, Nozaki, H, Itonori, S, Malik, S, Lebeer, S, Petrova, M, Balzarini, J, Vanderleyden, J, Naito-Matsui, Y, Takematsu, H, Murata, K, Kozutsumi, Y, Subedi, GP, Satoh, T, Hanashima, S, Ikeda, A, Nakada, H, Sato, R, Mizuno, M, Yuasa, N, Fujita-Yamaguchi, Y, Vlahakis, J, Nair, DG, Wang, Y, Allingham, J, Anastassiades, T, Strachan, H, Johnson, D, Orlando, R, Harenberg, J, Haji-Ghassemi, O, Mackenzie, R, Lacerda, T, Toledo, M, Straus, A, Takahashi, HK, Woodrum, B, Ruben, M, O'Keefe, B, Samli, KN, Yang, L, Woods, RJ, Jones, MB, Maxwell, J, Song, EH, Manganiello, M, Chow, YH, Convertine, AJ, Schnapp, LM, Stayton, PS, Ratner, DM, Yegorova, S, Rodriguez, MC, Minond, D, Jiménez-Barbero, J, Calle, L, Ardá, A, Gabius, HJ, André, S, Martinez-Mayorga, K, Yongye, AB, Cudic, M, Ali, MF, Chachadi, VB, Cheng, PW, Kiwamoto, T, Na, HJ, Brummet, M, Finn, MG, Hong, V, Polonskaya, Z, Bovin, NV, Hudson, S, Bochner, B, Gallogly, S, Krüger, A, Hanley, S, Gerlach, J, Hogan, M, Ward, C, Joshi, L, Griffin, M, Demarco, C, Deveny, R, Aggeler, R, Hart, C, Nyberg, T, Agnew, B, Akçay, G, Ramphal, J, Calabretta, P, Nguyen, AD, Kumar, K, Eggers, D, Terrill, R, d'Alarcao, M, Ito, Y, Vela, JL, Matsumura, F, Hoshino, H, Lee, H, Kobayashi, M, Borén, T, Jin, R, Seeberger, PH, Pitteloud, JP, Cudic, P, Von Muhlinen, N, Thurston, T, von Muhlinen, N, Wandel, M, Akutsu, M, Foeglein, AÁ, Komander, D, Randow, F, Maupin, K, Liden, D, Haab, B, Dam, TK, Brown, RK, Wiltzius, M, Jokinen, M, Andre, S, Kaltner, H, Bullen, J, Balsbaugh, J, Neumann, D, Hardie, G, Shabanowitz, J, Hunt, D, Hart, G, Mi, R, Ding, X, Van Die, I, Chapman, AB, Cummings, RD, Ju, T, Aryal, R, Ashley, J, Feng, X, Hanover, JA, Wang, P, Keembiyehetty, C, Ghosh, S, Bond, M, Krause, M, Love, D, Radhakrishnan, P, Grandgenet, PM, Mohr, AM, Bunt, SK, Yu, F, Hollingsworth, MA, Ethen, C, Machacek, M, Prather, B, Wu, Z, Kotu, V, Zhao, P, Zhang, D, van der Wel, H, Johnson, JM, West, CM, Abdulkhalek, S, Amith, SR, Jayanth, P, Guo, M, Szewczuk, M, Ohtsubo, K, Chen, M, Olefsky, J, Marth, J, Zapater, J, Foley, D, Colley, K, Kawashima, N, Fujitani, N, Tsuji, D, Itoh, K, Shinohara, Y, Nakayama, K, Zhang, L, Ten Hagen, K, Koren, S, Yehezkel, G, Cohen, L, Kliger, A, Khalaila, I, Finkelstein, E, Parker, R, Kohler, J, Sacoman, J, Badish, L, Hollingsworth, R, Tian, E, Hoffman, M, Hou, X, Tashima, Y, Stanley, P, Kizuka, Y, Kitazume, S, Yoshida, M, Kunze, A, Nasir, W, Bally, M, Hook, F, Larson, G, Mahan, A, Alter, G, Zeidan, Q, Copeland, R, Pokrovskaya, I, Willett, R, Smith, R, Morelle, W, Kudlyk, T, Lupashin, V, Vasudevan, D, Takeuchi, H, Majerus, E, Haltiwanger, RS, Boufala, S, Lee, YA, Min, D, Kim, SH, Shin, MH, Gesteira, T, Pol-Fachin, L, Coulson-Thomas, VJ, Verli, H, Nader, H, Liu, X, Yang, P, Thoden, J, Holden, H, Tytgat, H, Sánchez-Rodríguez, A, Schoofs, G, Verhoeven, T, De Keersmaecker, S, Marchal, K, Ventura, V, Sarah, N, Joann, P, Ding, Y, Jarrell, K, Cook, MC, Gibeault, S, Filippenko, V, Ye, Q, Wang, J, Kunkel, JP, Arteaga-Cabello, FJ, Arciniega-Fuentes, MT, McCoy, J, Ruiz-Palacios, GM, Francoleon, D, Loo, RO, Loo, J, Ytterberg, AJ, Kim, U, Gunsalus, R, Costello, C, Soares, R, Assis, R, Ibraim, I, Noronha, F, De Godoy, AP, Bale, MS, Xu, Y, Brown, K, Blader, I, West, C, Chen, S, Ye, X, Xue, C, Li, G, Yu, G, Yin, L, Chai, W, Gutierrez-Magdaleno, G, Tan, C, Wu, D, Li, Q, Hu, H, Ye, M, Liu, D, Mink, W, Kaese, P, Fujiwara, M, Uchimura, K, Sakai, Y, Nakada, T, Mabashi-Asazuma, H, Toth, AM, Scott, DW, Chacko, BK, Patel, RP, Batista, F, Mercer, N, Ramakrishnan, B, Pasek, M, Boeggeman, E, Verdi, L, Qasba, PK, Tran, D, Lim, JM, Liu, M, Mo, KF, Kirby, P, Yu, X, Lin, C, Costello, CE, Akama, TO, Nakamura, T, Huang, Y, Shi, X, Han, L, Yu, SH, Zhang, Z, Knappe, S, Till, S, Nadia, I, Catarello, J, Quinn, C, Julia, N, Ray, J, Tran, T, Scheiflinger, F, Szabo, C, Dockal, M, Niimi, S, Hosono, T, Michikawa, M, Kannagi, R, Takashima, S, Amano, J, Nakamura, N, Kaneda, E, Nakayama, Y, Kurosaka, A, Takada, W, Matsushita, T, Hinou, H, Nishimura, S, Igarashi, K, Abe, H, Mothere, M, Leonhard-Melief, C, Johnson, H, Nagy, T, Nairn, A, Rosa, MD, Porterfield, M, Kulik, M, Dalton, S, Pierce, JM, Hansen, SF, McAndrew, R, Degiovanni, A, McInerney, P, Pereira, JH, Hadi, M, Scheller, HV, Barb, A, Prestegard, J, Zhang, S, Jiang, J, Tharmalingam, T, Pluta, K, McGettigan, P, Gough, R, Struwe, W, Fitzpatrick, E, Gallagher, ME, Rudd, PM, Karlsson, NG, Carrington, SD, Katoh, T, Panin, V, Gelfenbeyn, K, Freire-de-Lima, L, Handa, K, Hakomori, SI, Bielik, AM, McLeod, E, Landry, D, Mendoza, V, Guthrie, EP, Mao, Y, Wang, X, Moremen, KW, Meng, L, Ramiah, AP, Gao, Z, Johnson, R, Xiang, Y, Rosa, MDEL, Wu, SC, Gilbert, HJ, Karaveg, K, Chen, L, Wang, BC, Mast, S, Sun, B, Fulton, S, Kimzey, M, Pourkaveh, S, Minalla, A, Haxo, T, Wegstein, J, Murray, AK, Nichols, RL, Giannini, S, Grozovsky, R, Begonja, AJ, Hoffmeister, KM, Suzuki-Anekoji, M, Suzuki, A, Yu, SY, Khoo, KH, van Alphen, L, Fodor, C, Wenzel, C, Ashmus, R, Miller, W, Stahl, M, Stintzi, A, Lowary, T, Wiederschain, G, Saba, J, Zumwalt, A, Meitei, NS, Apte, A, Viner, R, Gandy, M, Debowski, A, Stubbs, K, Witzenman, H, Pandey, D, Repnikova, E, Nakamura, M, Islam, R, Kc, N, Caster, C, Chaubard, JL, Krishnamurthy, C, Hsieh-Wilson, L, Pranskevich, J, Rangarajan, J, Guttman, A, Szabo, Z, Karger, B, Chapman, J, Chavaroche, A, Bionda, N, Fields, G, Jacob, F, Tse, BW, Guertler, R, Nixdorf, S, Hacker, NF, Heinzelmann-Schwarz, V, Yang, F, Kohler, JJ, Losfeld, ME, Ng, B, Freeze, HH, He, P, Wondimu, A, Liu, Y, Zhang, Y, Su, Y, Ladisch, S, Grewal, P, Mann, C, Ditto, D, Lardone, R, Le, D, Varki, N, Kulinich, A, Kostjuk, O, Maslak, G, Pismenetskaya, I, Shevtsova, A, Takeishi, S, Okudo, K, Moriwaki, K, Terao, N, Kamada, Y, Kuroda, S, Li, Y, Peiris, D, Markiv, A, Dwek, M, Adamczyk, B, Thanabalasingham, G, Huffman, J, Kattla, J, Novokmet, M, Rudan, I, Gloyn, A, Hayward, C, Reynolds, R, Hansen, T, Klimes, I, Njolstad, P, Wilson, J, Hastie, N, Campbell, H, McCarthy, M, Rudd, P, Owen, K, Lauc, G, Wright, A, Goletz, S, Stahn, R, Danielczyk, A, Baumeister, H, Hillemann, A, Löffler, A, Stöckl, L, Jahn, D, Bahrke, S, Flechner, A, Schlangstedt, M, Karsten, U, Goletz, C, Mikolajczyk, S, Ulsemer, P, Gao, N, Cline, A, Flanagan-Steet, H, Sadler, KC, Lehrman, MA, Coulson-Thomas, YM, Gesteira, TF, Mader, AM, Waisberg, J, Pinhal, MA, Friedl, A, Toma, L, Nader, HB, Mbua, EN, Johnson, S, Wolfert, M, Dimitrievska, S, Huizing, M, Niklason, L, Perdivara, I, Petrovich, R, Tokar, EJ, Waalkes, M, Fraser, P, Tomer, K, Chu, J, Rosa, S, Mir, A, Lehrman, M, Sadler, K, Lauer, M, Hascall, V, Calabro, A, Cheng, G, Swaidani, S, Abaddi, A, Aronica, M, Yuzwa, S, Shan, X, Macauley, M, Clark, T, Skorobogatko, Y, Vosseller, K, Vocadlo, D, Banerjee, A, Baksi, K, Banerjee, D, Melcher, R, Kraus, I, Moeller, D, Demmig, S, Rogoll, D, Kudlich, T, Scheppach, W, Scheurlen, M, Hasilik, A, Steirer, L, Lee, J, Moe, G, Troy, FA, Wang, F, Xia, B, Wang, B, Yi, S, Yu, H, Suzuki, M, Kobayashi, T, Sato, Y, Zhou, H, Briscoe, A, Lee, R, Wolfert, MA, Matsumoto, Y, Hamamura, K, Yoshida, T, Akita, K, Okajima, T, Furukawa, K, Urano, T, Ruhaak, LR, Miyamoto, S, and Lebrilla, CB

Subjects
Embryogenesis, Cancer screening, Cancer research, medicine, Cell migration, Neural cell adhesion molecule, Biology, medicine.disease, Biochemistry, Metastasis
Abstract

Cell surface mucins configure the cell surface by presenting extended protein backbones that are heavily O-glycosylated. The glycopeptide structures establish physicochemical properties at the cell surface that enable and block the formation of biologically important molecular complexes. Some mucins, such as MUC1, associate with receptor tyrosine kinases and other cell surface receptors, and engage in signal transduction in order to communicate information regarding conditions at the cell surface to the nucleus. In that context, the MUC1 cytoplasmic tail (MUC1CT) receives phosphorylation signals from receptor tyrosine kinases and serine/threonine kinases, which enables its association with different signaling complexes that conduct these signals to the nucleus and perhaps other subcellular organelles. We have detected the MUC1CT at promoters of over 500 genes, in association with several different transcription factors, and have shown that promoter occupancy can vary under different growth factor conditions. However, the full biochemical nature of the nuclear forms of MUC1 and its function at these promoter regions remain undefined. I will present evidence that nuclear forms of the MUC1CT include extracellular and cytoplasmic tail domains. In addition, I will discuss evidence for a hypothesis that the MUC1CT possesses a novel catalytic function that enables remodeling of the transcription factor occupancy of promoters, and thereby engages in regulation of gene expression.

Published
2016

32. IgG binding characteristics of rhesus macaque FcgR

Author

Chan, Y.N., Boesch, A.W., Osei-Owusu, N.Y., Emileh, A., Crowley, A.R., Cocklin, S.L., Finstad, S.L., Linde, C.H., Howell, R.A., Zentner, I., Cocklin, S., Miles, A.R., Eckman, J.W., Alter, G., Schmitz, J.E., Ackerman, M.E., and Publica

Abstract

Indian rhesus macaques (Macaca mulatta) are routinely used in preclinical studies to evaluate therapeutic Abs and candidate vaccines. The efficacy of these interventions in many cases is known to rely heavily on the ability of Abs to interact with a set of Ab FcgR expressed on innate immune cells. Yet, despite their presumed functional importance, M. mulatta Ab receptors are largely uncharacterized, posing a fundamental limit to ensuring accurate interpretation and translation of results from studies in this model. In this article, we describe the binding characteristics of the most prevalent allotypic variants of M. mulatta FcgR for binding to both human and M. mulatta IgG of varying subclasses. The resulting determination of the affinity, specificity, and glycan sensitivity of these receptors promises to be useful in designing and evaluating studies of candidate vaccines and therapeutic Abs in this key animal model and exposes significant evolutionary divergence between humans and macaques.

Published
2016

35. Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

Author

Sips, M., primary, Krykbaeva, M., additional, Diefenbach, T.J., additional, Ghebremichael, M., additional, Bowman, B.A., additional, Dugast, A-S, additional, Boesch, A.W., additional, Streeck, H., additional, Kwon, D.S., additional, Ackerman, M.E., additional, Suscovich, T.J., additional, Brouckaert, P., additional, Schacker, T.W., additional, and Alter, G., additional

Published
2016
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36. Prevention of SHIV transmission by topical IFN-β treatment

Author

Veazey, R.S., primary, Pilch-Cooper, H.A., additional, Hope, T.J., additional, Alter, G., additional, Carias, A.M., additional, Sips, M., additional, Wang, X., additional, Rodriguez, B., additional, Sieg, S.F., additional, Reich, A., additional, Wilkinson, P., additional, Cameron, M.J., additional, and Lederman, M.M., additional

Published
2016
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37. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16

Author

Gunn, B.M., primary, Schneider, J.R., additional, Shansab, M., additional, Bastian, A.R., additional, Fahrbach, K.M., additional, Smith, A.D., additional, Mahan, A.E., additional, Karim, M.M., additional, Licht, A.F., additional, Zvonar, I., additional, Tedesco, J., additional, Anderson, M.R., additional, Chapel, A., additional, Suscovich, T.J., additional, Malaspina, D.C., additional, Streeck, H., additional, Walker, B.D., additional, Kim, A., additional, Lauer, G., additional, Altfeld, M., additional, Pillai, S., additional, Szleifer, I., additional, Kelleher, N.L., additional, Kiser, P.F., additional, Hope, T.J., additional, and Alter, G., additional

Published
2016
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38. Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells

Author

Townsley, E, primary, O'Connor, G, additional, Cosgrove, C, additional, Woda, M, additional, Co, M, additional, Thomas, S J, additional, Kalayanarooj, S, additional, Yoon, I-K, additional, Nisalak, A, additional, Srikiatkhachorn, A, additional, Green, S, additional, Stephens, H A F, additional, Gostick, E, additional, Price, D A, additional, Carrington, M, additional, Alter, G, additional, McVicar, D W, additional, Rothman, A L, additional, and Mathew, A, additional

Published
2015
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40. Correction: Copy Number Variation of KIR Genes Influences HIV-1 Control

Author

Pelak, K, Need, A, Fellay, J, Shianna, K, Feng, S, Urban, T, Ge, D, De Luca, A, Martinez-Picado, J, Wolinsky, S, Martinson, J, Jamieson, B, Bream, J, Martin, M, Borrow, P, Letvin, N, McMichael, A, Haynes, B, Telenti, A, Carrington, M, Goldstein, D, Alter, G, and (CHAVI), on behalf of NIAID Center for HIV/AIDS Vaccine Immunology

Subjects
Genetics, General Immunology and Microbiology, QH301-705.5, General Neuroscience, Human immunodeficiency virus (HIV), Cancer, Correction, Biology, medicine.disease_cause, medicine.disease, General Biochemistry, Genetics and Molecular Biology, medicine, Copy-number variation, Biology (General), General Agricultural and Biological Sciences, Gene
Abstract

The affiliation for the twentieth author was incorrect. Mary Carrington is not affiliated with #10 but with #12 Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America. The author’s affiliation to #18 is unaffected.

Published
2011

43. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

Author

Klatt, N R, primary, Estes, J D, additional, Sun, X, additional, Ortiz, A M, additional, Barber, J S, additional, Harris, L D, additional, Cervasi, B, additional, Yokomizo, L K, additional, Pan, L, additional, Vinton, C L, additional, Tabb, B, additional, Canary, L A, additional, Dang, Q, additional, Hirsch, V M, additional, Alter, G, additional, Belkaid, Y, additional, Lifson, J D, additional, Silvestri, G, additional, Milner, J D, additional, Paiardini, M, additional, Haddad, E K, additional, and Brenchley, J M, additional

Published
2012
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