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5. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Author

Posth, C., Yu, H., Ghalichi, A., Rougier, H., Crevecoeur, I., Huang, Y., Ringbauer, H., Rohrlach, A., Nägele, K., Villalba-Mouco, V., Radzeviciute, R., Ferraz, T., Stoessel, A., Tukhbatova, R., Drucker, D., Lari, M., Modi, A., Vai, S., Saupe, T., Scheib, C., Catalano, G., Pagani, L., Talamo, S., Fewlass, H., Klaric, L., Morala, A., Rué, M., Madelaine, S., Crépin, L., Caverne, J., Bocaege, E., Ricci, S., Boschin, F., Bayle, P., Maureille, B., Le Brun-Ricalens, F., Bordes, J., Oxilia, G., Bortolini, E., Bignon-Lau, O., Debout, G., Orliac, M., Zazzo, A., Sparacello, V., Starnini, E., Sineo, L., van der Plicht, J., Pecqueur, L., Merceron, G., Garcia, G., Leuvrey, J., Garcia, C., Gómez-Olivencia, A., Połtowicz-Bobak, M., Bobak, D., Le Luyer, M., Storm, P., Hoffmann, C., Kabaciński, J., Filimonova, T., Shnaider, S., Berezina, N., González-Rabanal, B., Morales, G., R., M., Marín-Arroyo, A., López, B., Alonso-Llamazares, C., Ronchitelli, A., Polet, C., Jadin, I., Cauwe, N., Soler, J., Coromina, N., Rufí, I., Cottiaux, R., Clark, G., Straus, L., Julien, M., Renhart, S., Talaa, D., Benazzi, S., Romandini, M., Amkreutz, L., Bocherens, H., Wißing, C., Villotte, S., de Pablo, Fernández-López, J., Gómez-Puche, M., Esquembre-Bebia, M., Bodu, P., Smits, L., Souffi, B., Jankauskas, R., Kozakaitė, J., Cupillard, C., Benthien, H., Wehrberger, K., Schmitz, R., Feine, S., Schüler, T., Thevenet, C., Grigorescu, D., Lüth, F., Kotula, A., Piezonka, H., Schopper, F., Svoboda, J., Sázelová, S., Chizhevsky, A., Khokhlov, A., Conard, N., Valentin, F., Harvati, K., Semal, P., Jungklaus, B., Suvorov, A., Schulting, R., Moiseyev, V., Mannermaa, K., Buzhilova, A., Terberger, T., Caramelli, D., Altena, E., Haak, W., and Krause, J.

Abstract

Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants. Ancient DNA data generation Before the LGM LGM in southwestern and western Europe Post-LGM in the Italian peninsula Post-LGM in western and central Europe Post-14 ka to Neolithic Phenotypically relevant variants Discussion and conclusions Methods

Published
2023

6. The Anglo-Saxon migration and the formation of the early English gene pool

Author

Gretzinger, J, Sayer, D, Justeau, P, Altena, E, Pala, M, Dulias, K, Edwards, CJ, Jodoin, S, Lacher, L, Sabin, S, Vågene, ÅJ, Haak, W, Ebenesersdóttir, SS, Moore, KHS, Radzeviciute, R, Schmidt, K, Brace, S, Bager, MA, Patterson, N, Papac, L, Broomandkhoshbacht, N, Callan, K, Harney, É, Iliev, L, Lawson, AM, Michel, M, Stewardson, K, Zalzala, F, Rohland, N, Kappelhoff-Beckmann, S, Both, F, Winger, D, Neumann, D, Saalow, L, Krabath, S, Beckett, S, Van Twest, M, Faulkner, N, Read, C, Barton, T, Caruth, J, Hines, J, Krause-Kyora, B, Warnke, U, Schuenemann, VJ, Barnes, I, Dahlström, H, Clausen, JJ, Richardson, A, Popescu, E, Dodwell, N, Ladd, S, Phillips, T, Mortimer, R, Sayer, F, Swales, D, Stewart, A, Powlesland, D, Kenyon, R, Ladle, L, Peek, C, Grefen-Peters, S, Ponce, P, Daniels, R, Spall, C, Woolcock, J, Jones, AM, Roberts, AV, Symmons, R, Rawden, AC, Cooper, A, Bos, KI, Booth, T, Schroeder, H, Thomas, MG, Helgason, A, Richards, MB, Reich, D, Krause, J, Schiffels, S, Gretzinger, J, Sayer, D, Justeau, P, Altena, E, Pala, M, Dulias, K, Edwards, CJ, Jodoin, S, Lacher, L, Sabin, S, Vågene, ÅJ, Haak, W, Ebenesersdóttir, SS, Moore, KHS, Radzeviciute, R, Schmidt, K, Brace, S, Bager, MA, Patterson, N, Papac, L, Broomandkhoshbacht, N, Callan, K, Harney, É, Iliev, L, Lawson, AM, Michel, M, Stewardson, K, Zalzala, F, Rohland, N, Kappelhoff-Beckmann, S, Both, F, Winger, D, Neumann, D, Saalow, L, Krabath, S, Beckett, S, Van Twest, M, Faulkner, N, Read, C, Barton, T, Caruth, J, Hines, J, Krause-Kyora, B, Warnke, U, Schuenemann, VJ, Barnes, I, Dahlström, H, Clausen, JJ, Richardson, A, Popescu, E, Dodwell, N, Ladd, S, Phillips, T, Mortimer, R, Sayer, F, Swales, D, Stewart, A, Powlesland, D, Kenyon, R, Ladle, L, Peek, C, Grefen-Peters, S, Ponce, P, Daniels, R, Spall, C, Woolcock, J, Jones, AM, Roberts, AV, Symmons, R, Rawden, AC, Cooper, A, Bos, KI, Booth, T, Schroeder, H, Thomas, MG, Helgason, A, Richards, MB, Reich, D, Krause, J, and Schiffels, S

Abstract

The history of the British Isles and Ireland is characterized by multiple periods of major cultural change, including the influential transformation after the end of Roman rule, which precipitated shifts in language, settlement patterns and material culture1. The extent to which migration from continental Europe mediated these transitions is a matter of long-standing debate2–4. Here we study genome-wide ancient DNA from 460 medieval northwestern Europeans—including 278 individuals from England—alongside archaeological data, to infer contemporary population dynamics. We identify a substantial increase of continental northern European ancestry in early medieval England, which is closely related to the early medieval and present-day inhabitants of Germany and Denmark, implying large-scale substantial migration across the North Sea into Britain during the Early Middle Ages. As a result, the individuals who we analysed from eastern England derived up to 76% of their ancestry from the continental North Sea zone, albeit with substantial regional variation and heterogeneity within sites. We show that women with immigrant ancestry were more often furnished with grave goods than women with local ancestry, whereas men with weapons were as likely not to be of immigrant ancestry. A comparison with present-day Britain indicates that subsequent demographic events reduced the fraction of continental northern European ancestry while introducing further ancestry components into the English gene pool, including substantial southwestern European ancestry most closely related to that seen in Iron Age France5,6.

Published
2022

7. Insomnia evaluation and treatment during peripartum: a joint position paper from the European Insomnia Network task force 'Sleep and Women,' the Italian Marcè Society and international experts task force for perinatal mental health

Author

Palagini, L., Bramante, A., Baglioni, C., Tang, N., Grassi, L., Altena, E., Johann, A. F., Geoffroy, P. A., Biggio, G., Mencacci, C., Sharma, V., and Riemann, D.

Subjects
Treatment, Cognitive behavioral therapy for insomnia (CBT-I), Insomnia, Pregnancy, Socio-culturale, Evaluation, Peripartum
Published
2022

9. Ten millennia of hepatitis B virus evolution

Author

Kocher, A, Papac, L, Barquera, R, Key, FM, Spyrou, MA, Hubler, R, Rohrlach, AB, Aron, F, Stahl, R, Wissgott, A, van Bommel, F, Pfefferkorn, M, Mittnik, A, Villalba-Mouco, V, Neumann, GU, Rivollat, M, van de Loosdrecht, MS, Majander, K, Tukhbatova, R, Musralina, L, Ghalichi, A, Penske, S, Sabin, S, Michel, M, Gretzinger, J, Nelson, EA, Ferraz, T, Nagele, K, Parker, C, Keller, M, Guevara, EK, Feldman, M, Eisenmann, S, Skourtanioti, E, Giffin, K, Gnecchi-Ruscone, GA, Friederich, S, Schimmenti, V, Khartanovich, V, Karapetian, MK, Chaplygin, MS, Kufterin, VV, Khokhlov, AA, Chizhevsky, AA, Stashenkov, DA, Kochkina, AF, Tejedor-Rodriguez, C, Garcia-Martinez de Lagran, I, Arcusa-Magallon, H, Garrido-Pena, R, Ignacio Royo-Guillen, J, Novacek, J, Rottier, S, Kacki, S, Saintot, S, Kaverzneva, E, Belinskiy, AB, Veleminsky, P, Limbursky, P, Kostka, M, Loe, L, Popescu, E, Clarke, R, Lyons, A, Mortimer, R, Sajantila, A, Chinique de Armas, Y, Hernandez Godoy, ST, Hernandez-Zaragoza, D, Pearson, J, Binder, D, Lefranc, P, Kantorovich, AR, Maslov, VE, Lai, L, Zoledziewska, M, Beckett, JF, Langova, M, Ingman, T, Garcia Atienzar, G, de Miguel Ibanez, MP, Romero, A, Sperduti, A, Beckett, S, Salter, SJ, Zilivinskaya, ED, Vasil, DV, von Heyking, K, Burger, RL, Salazar, LC, Amkreutz, L, Navruzbekov, M, Rosenstock, E, Alonso-Fernandez, C, Slavchev, V, Kalmykov, AA, Atabiev, BC, Batieva, E, Alvarez Calmet, M, Llamas, B, Schultz, M, Krauss, R, Jimenez-Echevarria, J, Francken, M, Shnaider, S, de Knijff, P, Altena, E, Van de Vijver, K, Fehren-Schmitz, L, Tung, TA, Losch, S, Dobrovolskaya, M, Makarov, N, Read, C, Van Twest, M, Sagona, C, Ramsl, PC, Akar, M, Yener, KA, Carmona Ballestero, E, Cucca, F, Mazzarello, V, Utrilla, P, Rademaker, K, Fernandez-Dominguez, E, Baird, D, Semal, P, Marquez-Morfin, L, Roksandic, M, Steiner, H, Carlos Salazar-Garcia, D, Shishlina, N, Erdal, YS, Hallgren, F, Boyadzhiev, Y, Boyadzhiev, K, Kuessner, M, Sayer, D, Onkamo, P, Skeates, R, Rojo-Guerra, M, Buzhilova, A, Khussainova, E, Djansugurova, LB, Beisenov, AZ, Samashev, Z, Massy, K, Mannino, M, Moiseyev, V, Mannermaa, K, Balanovsky, O, Deguilloux, M-F, Reinhold, S, Hansen, S, Kitov, EP, Dobes, M, Ernee, M, Meller, H, Alt, KW, Prufer, K, Warinner, C, Schiffels, S, Stockhammer, PW, Bos, K, Posth, C, Herbig, A, Haak, W, Krause, J, Kuehnert, D, Kocher, A, Papac, L, Barquera, R, Key, FM, Spyrou, MA, Hubler, R, Rohrlach, AB, Aron, F, Stahl, R, Wissgott, A, van Bommel, F, Pfefferkorn, M, Mittnik, A, Villalba-Mouco, V, Neumann, GU, Rivollat, M, van de Loosdrecht, MS, Majander, K, Tukhbatova, R, Musralina, L, Ghalichi, A, Penske, S, Sabin, S, Michel, M, Gretzinger, J, Nelson, EA, Ferraz, T, Nagele, K, Parker, C, Keller, M, Guevara, EK, Feldman, M, Eisenmann, S, Skourtanioti, E, Giffin, K, Gnecchi-Ruscone, GA, Friederich, S, Schimmenti, V, Khartanovich, V, Karapetian, MK, Chaplygin, MS, Kufterin, VV, Khokhlov, AA, Chizhevsky, AA, Stashenkov, DA, Kochkina, AF, Tejedor-Rodriguez, C, Garcia-Martinez de Lagran, I, Arcusa-Magallon, H, Garrido-Pena, R, Ignacio Royo-Guillen, J, Novacek, J, Rottier, S, Kacki, S, Saintot, S, Kaverzneva, E, Belinskiy, AB, Veleminsky, P, Limbursky, P, Kostka, M, Loe, L, Popescu, E, Clarke, R, Lyons, A, Mortimer, R, Sajantila, A, Chinique de Armas, Y, Hernandez Godoy, ST, Hernandez-Zaragoza, D, Pearson, J, Binder, D, Lefranc, P, Kantorovich, AR, Maslov, VE, Lai, L, Zoledziewska, M, Beckett, JF, Langova, M, Ingman, T, Garcia Atienzar, G, de Miguel Ibanez, MP, Romero, A, Sperduti, A, Beckett, S, Salter, SJ, Zilivinskaya, ED, Vasil, DV, von Heyking, K, Burger, RL, Salazar, LC, Amkreutz, L, Navruzbekov, M, Rosenstock, E, Alonso-Fernandez, C, Slavchev, V, Kalmykov, AA, Atabiev, BC, Batieva, E, Alvarez Calmet, M, Llamas, B, Schultz, M, Krauss, R, Jimenez-Echevarria, J, Francken, M, Shnaider, S, de Knijff, P, Altena, E, Van de Vijver, K, Fehren-Schmitz, L, Tung, TA, Losch, S, Dobrovolskaya, M, Makarov, N, Read, C, Van Twest, M, Sagona, C, Ramsl, PC, Akar, M, Yener, KA, Carmona Ballestero, E, Cucca, F, Mazzarello, V, Utrilla, P, Rademaker, K, Fernandez-Dominguez, E, Baird, D, Semal, P, Marquez-Morfin, L, Roksandic, M, Steiner, H, Carlos Salazar-Garcia, D, Shishlina, N, Erdal, YS, Hallgren, F, Boyadzhiev, Y, Boyadzhiev, K, Kuessner, M, Sayer, D, Onkamo, P, Skeates, R, Rojo-Guerra, M, Buzhilova, A, Khussainova, E, Djansugurova, LB, Beisenov, AZ, Samashev, Z, Massy, K, Mannino, M, Moiseyev, V, Mannermaa, K, Balanovsky, O, Deguilloux, M-F, Reinhold, S, Hansen, S, Kitov, EP, Dobes, M, Ernee, M, Meller, H, Alt, KW, Prufer, K, Warinner, C, Schiffels, S, Stockhammer, PW, Bos, K, Posth, C, Herbig, A, Haak, W, Krause, J, and Kuehnert, D

Abstract

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.

Published
2021

10. Ten millennia of hepatitis B virus evolution

Author

Ingman, Tara, Kocher, A.; Papac, L.; Barquera, R.; Key, FM.; Spyrou, MA.; Hubler, R.; Rohrlach, AB.; Aron, F.; Stahl, R.; Wissgott, A.; van Bommel, F.; Pfefferkorn, M.; Mittnik, A.; Villalba-Mouco, V.; Neumann, GU.; Rivollat, M.; van de Loosdrecht, MS.; Majander, K.; Tukhbatova, RI.; Musralina, L.; Ghalichi, A.; Penske, S.; Sabin, S.; Michel, M.; Gretzinger, J.; Nelson, EA.; Ferraz, T.; Nagele, K.; Parker, C.; Keller, M.; Guevara, EK.; Feldman, M.; Eisenmann, S.; Skourtanioti, E.; Giffin, K.; Gnecchi-Ruscone, GA.; Friederich, S.; Schimmenti, V.; Khartanovich, V.; Karapetian, MK.; Chaplygin, MS.; Kufterin, VV.; Khokhlov, AA.; Chizhevsky, AA.; Stashenkov, DA.; Kochkina, AF.; Tejedor-Rodriguez, C.; de Lagran, IGM.; Arcusa-Magallon, H.; Garrido-Pena, R.; Royo-Guillen, JI.; Novacek, J.; Rottier, S.; Kacki, S.; Saintot, S.; Kaverzneva, E.; Belinskiy, AB.; Veleminsky, P.; Limbursky, P.; Kostka, M.; Loe, L.; Popescu, E.; Clarke, R.; Lyons, A.; Mortimer, R.; Sajantila, A.; de Armas, YC.; Godoy, STH.; Hernandez-Zaragoza, DI.; Pearson, J.; Binder, D.; Lefranc, P.; Kantorovich, AR.; Maslov, VE.; Lai, L.; Zoledziewska, M.; Beckett, JF.; Langova, M.; Atienzar, GG.; Ibanez, MPD; Romero, A.; Sperduti, A.; Beckett, S.; Salter, SJ.; Zilivinskaya, ED.; Vasil, DV.; von Heyking, K.; Burger, RL.; Salazar, LC.; Amkreutz, L.; Navruzbekov, M.; Rosenstock, E.; Alonso-Fernandez, C.; Slavchev, V.; Kalmykov, AA.; Atabiev, BC.; Batieva, E; Calmet, MA.; Llamas, B.; Schultz, M.; Krauss, R.; Jimenez-Echevarria, J.; Francken, M.; Shnaider, S.; de Knijff, P.; Altena, E.; Van de Vijver, K.; Fehren-Schmitz, L.; Tung, TA.; Losch, S.; Dobrovolskaya, M.; Makarov, N.; Read, C.; Van Twest, M.; Sagona, C.; Ramsl, PC.; Akar, M.; Yener, KA.; Ballestero, EC.; Cucca, F.; Mazzarello, V.; Utrilla, P.; Rademaker, K.; Fernandez-Dominguez, E.; Baird, D.; Semal, P.; Marquez-Morfin, L; Roksandic, M.; Steiner, H.; Salazar-Garcia, DC.; Shishlina, N. Erdal, YS.; Hallgren, F.; Boyadzhiev, Y.; Boyadzhiev, K.; Kussner, M.; Sayer, D.; Onka, Koç University Research Center for Anatolian Civilizations (ANAMED) / Koç Üniversitesi Anadolu Medeniyetleri Araştırma Merkezi (ANAMED), Ingman, Tara, Kocher, A.; Papac, L.; Barquera, R.; Key, FM.; Spyrou, MA.; Hubler, R.; Rohrlach, AB.; Aron, F.; Stahl, R.; Wissgott, A.; van Bommel, F.; Pfefferkorn, M.; Mittnik, A.; Villalba-Mouco, V.; Neumann, GU.; Rivollat, M.; van de Loosdrecht, MS.; Majander, K.; Tukhbatova, RI.; Musralina, L.; Ghalichi, A.; Penske, S.; Sabin, S.; Michel, M.; Gretzinger, J.; Nelson, EA.; Ferraz, T.; Nagele, K.; Parker, C.; Keller, M.; Guevara, EK.; Feldman, M.; Eisenmann, S.; Skourtanioti, E.; Giffin, K.; Gnecchi-Ruscone, GA.; Friederich, S.; Schimmenti, V.; Khartanovich, V.; Karapetian, MK.; Chaplygin, MS.; Kufterin, VV.; Khokhlov, AA.; Chizhevsky, AA.; Stashenkov, DA.; Kochkina, AF.; Tejedor-Rodriguez, C.; de Lagran, IGM.; Arcusa-Magallon, H.; Garrido-Pena, R.; Royo-Guillen, JI.; Novacek, J.; Rottier, S.; Kacki, S.; Saintot, S.; Kaverzneva, E.; Belinskiy, AB.; Veleminsky, P.; Limbursky, P.; Kostka, M.; Loe, L.; Popescu, E.; Clarke, R.; Lyons, A.; Mortimer, R.; Sajantila, A.; de Armas, YC.; Godoy, STH.; Hernandez-Zaragoza, DI.; Pearson, J.; Binder, D.; Lefranc, P.; Kantorovich, AR.; Maslov, VE.; Lai, L.; Zoledziewska, M.; Beckett, JF.; Langova, M.; Atienzar, GG.; Ibanez, MPD; Romero, A.; Sperduti, A.; Beckett, S.; Salter, SJ.; Zilivinskaya, ED.; Vasil, DV.; von Heyking, K.; Burger, RL.; Salazar, LC.; Amkreutz, L.; Navruzbekov, M.; Rosenstock, E.; Alonso-Fernandez, C.; Slavchev, V.; Kalmykov, AA.; Atabiev, BC.; Batieva, E; Calmet, MA.; Llamas, B.; Schultz, M.; Krauss, R.; Jimenez-Echevarria, J.; Francken, M.; Shnaider, S.; de Knijff, P.; Altena, E.; Van de Vijver, K.; Fehren-Schmitz, L.; Tung, TA.; Losch, S.; Dobrovolskaya, M.; Makarov, N.; Read, C.; Van Twest, M.; Sagona, C.; Ramsl, PC.; Akar, M.; Yener, KA.; Ballestero, EC.; Cucca, F.; Mazzarello, V.; Utrilla, P.; Rademaker, K.; Fernandez-Dominguez, E.; Baird, D.; Semal, P.; Marquez-Morfin, L; Roksandic, M.; Steiner, H.; Salazar-Garcia, DC.; Shishlina, N. Erdal, YS.; Hallgren, F.; Boyadzhiev, Y.; Boyadzhiev, K.; Kussner, M.; Sayer, D.; Onka, and Koç University Research Center for Anatolian Civilizations (ANAMED) / Koç Üniversitesi Anadolu Medeniyetleri Araştırma Merkezi (ANAMED)

Abstract

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic., European Union (EU); Horizon 2020; European Research Council (ERC); Research and Innovation Program; PALEoRIDER; CoDisEASe; ARCHCAUCASUS; Seventh Framework Programme; Marie Curie Actions; Programme SASPRO; ERA.NET RUS Plus-S&T Programme; Institute of Archaeology of the Czech Academy of Sciences; Russian Foundation for Basic Research; German Research Foundation; French National Research Agency; Wenner-Gren Dissertation Fieldwork Grant; Ministry of Education and Science of the Republic of Kazakhstan; Max Planck Society; Slovak Academy of Sciences; Werner Siemens Stiftung; Paleobiochemistry; Award Praemium Academiae of the Czech Academy of Sciences

Published
2021

12. Poster abstracts

Author

Ferrie, J., Shipley, M., Cappuccio, F., Brunner, E., Miller, M., Kumari, M., Marmot, M., Coenen, A., Castillo, J. L., Araya, F., Bustamante, G., Montecino, L., Torres, C., Oporto, S., Gronli, J., Fiske, E., Murison, R., Bjorvatn, B., Sorensen, E., Ursin, R., Portas, C. M., Rajaraman, S., Gribok, A., Wesensten, N., Balkin, T., Reifman, J., Dursunoglu, N., Ozkurt, S., Baser, S., Delen, O., Sarikaya, S., Sadler, P., Mitchell, P., Françon, D., Decobert, M., Herve, B., Richard, A., Griebel, G., Avenet, P., Scatton, B., Fur, G. L., Eckert, D., Jordan, A., Wellman, A., Smith, S., Malhotra, A., White, D., Bruck, D., Thomas, I., Kritikos, A., Oertel, W., Stiasny-Kolster, K., Garcia-Borreguero, D., Poewe, W., Hoegl, B., Kohnen, R., Schollmayer, E., Keffel, J., Trenkwalder, C., Valle, A., Roizenblatt, S., Fregni, F., Boggio, P., Tufik, S., Ward, K., Robertson, L., Palmer, L., Eastwood, P., Hillman, D., Lee, J., Mukherjee, S., de Padova, V., Barbato, G., Ficca, G., Zilli, I., Salzarulo, P., Veldi, M., Hion, T., Vasar, V., Kull, M., Nowak, L., Davis, J., Latzer, Y., Tzischinsky, O., Crowley, S., Carskadon, M., Anca-Herschkovitsch, M., Frey, D., Ortega, J., Wiseman, C., Farley, C., Wright, K., Campbell, A., Neill, A., Spiegel, K., Leproult, R., Tasali, E., Scherberg, N., van Cauter, E., Noradina, A. T., Karim, N. A., Norlinah, I., Raymond, A. A., Sahathevan, R., Hamidon, B., Werth, E., Poryazova, R., Khatami, R., Bassetti, C., Beran, R. G., Ainley, L., Holand, G., Duncan, J., Kinney, H., Davis, B., Hood, B., Frey, S., Schmidt, C., Hofstetter, M., Peigneux, P., Cajochen, C., Hu, W.-P., Li, J.-D., Zhang, C., Boehmer, L., Siegel, J., Zhou, Q.-Y., Sagawa, Y., Kondo, H., Takemura, T., Kanayama, H., Kaneko, Y., Sato, M., Kanbayashi, T., Hishikawa, Y., Shimizu, T., Viola, A., James, L., Schlangen, L., Dijk, D.-J., Andretic, R., Kim, Y.-C., Han, K.-A., Jones, F., Greenspan, R., Sanford, L., Yang, L., Tang, X., Dieter, K., Uta, E., Sven, H., Richard, M., Oyane, N., Pallesen, S., Holsten, F., Inoue, Y., Fujita, M., Emura, N., Kuroda, K., Uchimura, N., Johnston, A., Astbury, J., Kennedy, G., Hoedlmoser, K., Schabus, M., Pecherstorfer, T., Moser, S., Gruber, G., Anderer, P., Klimesch, W., Naidoo, N., Ferber, M., Pack, A., Neu, D., Mairesse, O., Hoffmann, G., Dris, A., Lambrecht, L., Linkowski, P., Verbanck, P., Le Bon, O., Matsuura, N., Yamao, M., Adachi, N., Aritomi, R., Komada, Y., Tanaka, H., Shirakawa, S., Kondoh, H., Takemura, F., Ohnuma, S., Suzuki, M., Uemura, S., Iskra-Golec, I., Smith, L., Thanh, D.-V., Boly, M., Phillips, C., Steven, L., Luxen, A., Maquet, M., Jay, S., Dawson, D., Lamond, N., Basner, M., Fomberstein, K., Dinges, D., Ogawa, K., Nittono, H., Yamazaki, K., Hori, T., Glamann, C., Hornung, O., Hansen, M.-L, Danker-Hopfe, H., Jung, C., Kecklund, G., Anund, A., Peters, B., Åkerstedt, T., Verster, J., Roehrs, T., Mets, M., de Senerpont Domis, L., Olivier, B., Volkerts, E., Knutson, K., Lauderdale, D., Rathouz, P., Christie, M., Chen, L., Bolortuya, Y., Lee, E., Mckenna, J., Mccarley, R., Strecker, R., Tamaki, M., Matsuoka, T., Aritake, S., Suzuki, H., Kuriyama, K., Ozaki, A., Abe, Y., Enomoto, M., Tagaya, H., Mishima, K., Matsuura, M., Uchiyama, M., Lima-Pacheco, E., Davis, K., Sabourin, C., Lortie-Lussier, M., de Koninck, J., van Der Werf, Y., van Der Helm, E., Schoonheim, M., van Someren, E., Tokley, M., Ball, M., Sato, T., Ghilardi, M. F., Moisello, C., Bove, M., Busi, M., Pelosin, E., Tononi, G., Eguchi, N., Sakata, M., Urade, Y., Doe, N., Yoshihara, K., Abe, K., Manabe, Y., Iwatsuki, K., Hayashi, T., Shoji, M., Kamiya, T., Gooley, J., Brainard, G., Rajaratnam, S., Kronauer, R., Czeisler, C., Lockley, S., Phillips, A., Robinson, P., Burgess, H., Revell, V., Eastman, C., Bihari, S., Ramakrishnan, N., Camerino, D., Conway, P. M., Costa, G., Vandewalle, G., Albouy, G., Sterpenich, V., Darsaud, A., Rauchs, G., Berken, P.-Y, Balteau, E., Maquet, P., Tendero, J. A., Domenech, M. P., Isern, F. S., Martínez, C., Roure, N., Sancho, E. E., Moreno, C. R., Silva, M., Marqueze, E. C., Waage, S., Bobko, N., Chernyuk, V., Yavorskiy, Y., Saxvig, I., Sørensen, E., de Mello, M. T., Esteves, A., Teixeira, C., Bittencourt, L. R., Silva, R., Pires, M. L., Mottram, V., Middelton, B., Arendt, J., Amaral, O., Rodrigues, M., Pereira, C., Tavares, I., Baba, K., Honma, S., Honma, K.-I., Yamanaka, Y., Hashimoto, S., Tanahashi, Y., Nishide, S.-Y, Honma, K.-I, Sletten, T., Middleton, B., Lederle, K., Skene, D., Roth, T., Walsh, J., Hogben, A., Ellis, J., Archer, S., von Schantz, M., Chen, N.-H., Wang, P.-C., Chen, C.-W., Lin, Y., Shih, T.-S., Armstrong, S., Redman, J., Stephan, E., David, M., Delanaud, S., Chardon, K., Libert, J.-P., Bach, V., Telliez, F., Reid, K., Jaksa, A., Eisengart, J., Kane, P., Naylor, E., Zee, P., Viola, A. U., de Valck, E., Hofmans, J., Theuns, P., Cluydts, R., Alexander, G., Karel, M., Christina, R., Sohn, I.-K., Cho, I. H., Kim, S. J., Yu, S.-H., Kim, H., Yoo, S. Y., Koh, S.-H., Cho, S.-J., Rotenberg, L., Silva-Costa, A., Griep, R. H., Amely, T., Kennedy, G. 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Y. S., Cassaglia, P., Yu, V. Y. H., Walker, A. M., Kohler, M., Kennedy, D., Martin, J., van Den Heuvel, C., Lushington, K., Herron, K., Khurana, C., Sterr, A., Olivadoti, M., Toth, L., Opp, M., Dang-Vu, T., Degueldre, C., Gais, S., Dang-Vu, T. T., Desseilles, M., Philips, C., Chijavadze, E., Babilodze, M., Chkhartishvili, E., Nachkebia, N., Mchedlidze, O., Dzadzamia, S., Griffiths, R., Walker, A., Horovitz, S., Fukunaga, M., Carr, W., Picchioni, D., de Zwart, J., van Gelderen, P., Braun, A., Duyn, J., Hanlon, E. H., Faraguna, U., Vyazovskiy, V., Cirelli, C., Ocampo-Garcés, A., Ibáñez, F., López, S., Vivaldi, E., Torrealba, F., Romanowski, C. P. 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L., Nagai, R., do Rosário Dias De Oliveira Latorre, M., Marina, F., Paterson, J., Jackson, M., Johnston, P., Papafotiou, K., Croft, R., Dawson, S., Leenaars, C., Sandberg, H., Joosten, R., Dematteis, M., Feenstra, M., Wehrle, R., Rieger, M., Widmann, A., Dietl, T., Philipp, S., Wetter, T., Drummond, S., Czisch, M., Cairns, A., Lebourgeois, M., Harsh, J., Baulk, S., Vakulin, A., Catcheside, P., Antic, N., Mcevoy, D., Orff, H., Salamat, J., Meloy, M. 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V., Faria Sa, P., Yoon, I.-Y., Chung, S., Hee Lee, C., Kim, J.-W., Faludi, B., Wang, X., Li, Q., Wan, H., Li, M., Pallayova, M., Donic, V., Tomori, Z., Ioacara, S., Olech, T., Mccallum, C., Bowes, M., Bowes, J., Chia, M., Gilbert, S. S., Sajkov, D., Teichtahl, H., Stevenson, I., Cunnington, D., Kalman, J., Szaboova, E., Higami, S., Kryger, M., Higami, Y., Suzuki, C., Kitano, H., Carin, S., Olof, S., Yngve, G., Gösta, B., Carlberg, B., Stenlund, H., Franklin, K. A., Oliveira, A., Vasconcelos, L., Martinez, D., Goncalves, S. C., Gus, M., Silva, E. O. A., Fuchs, S. C., Fuchs, F. D., Li, A., Au, J., Ho, C., Sung, R., Wing, Y., Tada, H., Terada, N., Togawa, K., Nakagawa, Y., Kishida, K., Kihara, S., Hirata, A., Sonoda, M., Nishizawa, H., Nakamura, T., Shimomura, I., Funahashi, T., Andrewartha, P., Sasse, A., Becker, M., Troester, N., Olschewski, H., Lisamayerkard, L., Glos, M., Blau, A., Peter, J.-G., Chesworth, W., Wilson, G., Piper, A., Chuang, L.-P., Lin, S.-W., Wang, C.-J., Li, H.-Y., Chou, Y.-T., Fu, J.-Y., Liao, Y.-F., Tsai, Y.-H., Chan, K., Laks, L., Nishibayashi, M., Miyamoto, M., Miyamoto, T., Hirata, K., Hoever, P., De Haas, S., Chiossi, E., Van Gerven, J., Dingemanse, J., Winkler, J., Cavallaro, M., Narui, K., Kasai, T., Dohl, T., Takaya, H., Kawana, F., Ueno, K., Panjwani, U., Thakur, L., Anand, J. P., Banerjee, P. K., Leigh, M., Paduch, A., Armstrong, J., Sampson, D., Kotajima, F., Mochizuki, T., Lorr, D., Harder, H., Chesworth, M., Becker, H., Abd-Elaty, N. M., Elprince, M., Ismail, N., Elserogi, W., Yeo, A., George, K., Thomson, K., Stadler, D., Bradley, J., Paul, D., Schwartz, A., Hagander, L., Harlid, R., Hultcrantz, E., Haraldsson, P., Cho, J.-G., Narayan, J., Nagarajah, M., Perri, R., Johnson, P., Burgess, K., Chau, N., Mcevoy, R. D., Arnardottir, E. S., Thorleifsdottir, B., Olafsson, I., Gislason, T., Tsuiki, S., Fujimatsu, S., Munezawa, T., Sato, Y., Subedi, P., Ainslie, P., Topor, Z., Whitelaw, W., Chan, M., So, H., Lam, H., Ng, S., Chan, I., Lam, C., Saigusa, H., Higurashi, N., He, Z. M., Cui, X. C., Li, J., Dong, X., Lv, Y., Zhou, M., Han, X., An, P., Wang, L., Macey, P. M., Serber, S., Cross, R., Yan-Go, F., Marshall, M., Rees, D., Lee, S. H., Ho Cho, J. I., Shin, C., Lee, J. Y., Kwon, S. Y., Kim, T.-H., Vedam, H., Barnes, D., Walter, H., Karin, J., Hermann, P., Belyavskiy, E., Galitsyn, P., Arbolishvili, G., Litvin, A., Chazova, I., Mareev, V., Ramar, K., Khan, A., Gay, P., Strömberg, A., Ulander, M., Fridlund, B., Mårtensson, J., Yee, B., Desai, A., Buchanan, P., Crompton, R., Melehan, K., Wong, P., Tee, A., Ng, A., Darendeliler, M. A., Ye, L., Maislin, G., Hurley, S., Mccluskey, S., Weaver, T., Yun, C.-H., Ji, K.-H., Ahn, J. Y., Lee, H.-W., Zhang, X., Yin, K., Zhaofang, G., Chong, L., Navailles, B., Zenou, E., Cheze, L., Pignat, J.-C., Tang, T., Remmers, J., Vasilakos, K., Denotti, A., Gilholme, J., Castronovo, V., Marelli, S., Aloia, M., Fantini, M. L., Kuo, T., Manconi, M., Zucconi, M., Ferini-Strambi, L., Livia Fantini, M., Giarolli, L., Oldani, A., Lee, Y., Trenell, M., Berend, N., Wang, M., Liang, Z., Lei, F., Komada, I., Nishikawa, M., Sriram, K., Mignone, L., Antic, R., Fujiwara, K., Beaudry, M., Gauthier, L., Laforte, M., Lavigne, G., Wylie, P., Orr, W., Grover, S., Geisler, P., Engelke, E., Cossa, G., Veitch, E., Brillante, R., Mcardle, N., Murphy, M., Singh, B., Gain, K., Maguire, C., Mutch, S., Brown, S., Asciuto, T., Newsam, C., Fransson, A., Ísacsson, G., Tsou, M.-C., Hsu, S.-P., Almendros, I., Acerbi, I., Vilaseca, I., Dcruz, O., Vaughn, B., Muenzer, J., Lacassagne, L., Montemayor, T., Roch-Paoli, J., Qian, J., Petocz, P., Chan, M. R., Munro, J., Zimmerman, M., Stanchina, M., Millman, R., Cassel, W., Ploch, T., Loh, A., Koehler, U., Jerrentrup, A., Greulich, T., Doyle, G., Pascoe, T., Jorgensen, G., Baglioni, C., Lombardo, C., Espie, C., Violani, C., Edell-Gustafsson, U., Swahn, E., Ejdeback, J., Tygesen, H., Johansson, A., Neckelmann, D., Hilde Nordhus, I., Zs-Kovács, Á., Vámos, E., Zs-Molnár, M., Maisuradze, L., Gugushvili, J., Darchia, N., Gvilia, I., Lortkipanidze, N., Oniani, N., Wang-Weigand, S., Mayer, G., Roth-Schechter, B., Hsu, S.-C., Yang, C.-M., Liu, C.-Y., Ito, H., Omvik, S., Nordhus, I. H., Farber, R., Scharf, M., Harris-Collazo, R., Pereira, J., Andras, S., Ohayon, M., David, B., Morgan, K., Voorn, T., Vis, J., Kuijer, J., Fortier-Brochu, E., Beaulieu-Bonneau, S., Ivers, H., Morin, C., Beaulieu-Benneau, S., Harris, J., Bartlett, D., Paisley, L., Moncada, S., Toelle, B., Bonnet, M. H., Arand, D., Bonnet, J., Bonnet, M., Doi, Y., Edéll-Gustafsson, U., Strijers, R., Fernando, A., Arroll, B., Warman, G., Funakura, M., Shikano, S., Unemoto, Y., Fujisawa, M., Hong, S.-C., Jeong, J.-H., Shin, Y.-K., Han, J.-H., Lee, S.-P., Lee, J.-H., Mignot, E., Nakajima, T., Hayashida, K., Honda, M., Ardestani, P., Etemadifar, M., Nejadnik, H., Maghzi, A. H., Basiri, K., Ebrahimi, A., Davoodi, M., Peraita-Adrados, R., Vicario, J. L., Shin, H.-B., Marti, I., Carriero, L., Fulda, S., Beitinger, P., Pollmacher, T., Lam, J. S. P., Fong, S. Y. Y., Tang, N. L. S., Ho, C. K. W., Li, A. M. C., Wing, Y. K., Guilleminault, C., Black, J., Wells, C., Kantor, S., Janisiewicz, A., Scammell, T., Tanaka, S., Smith, A., Neufing, P., Gordon, T., Fuller, P., Gompf, H., Pedersen, N., Saper, C., Lu, J., Sasai, T., Donjacour, C., Fronczek, R., Le Cessie, S., Lammers, G. J., van Dijk, J. G., Hayashi-Ogawa, Y., Okuda, M., Lam, V. K.-H., Chen, A. L., Ho, C. K.-W., Wing, Y.-K., Lehrhaft, B., Brilliante, R., van Der Zande, W., Overeem, S., van Dijk, G., Lammers, J. G., Opazo, C. J., Jeong, D.-U., Sung, Y. H., Lyoo, I. K., Takahashi, Y., Murasaki, M., Bloch, K., Jung, H., Dahab, M. M., Campos, T. F., Mccabe, S., Maravic, K., Wiggs, L., Connelly, V., Barnes, J., Saito, Y., Ogawa, M., Murata, M., Nadig, U., Rahman, A., Aritake, K., D’Cruz, O., Suzuki, K., Kaji, Y., Takekawa, H., Nomura, T., Yasui, K., Nakashima, K., Bahammam, A., Rab, M. G., Owais, S., Alsuwat, K., Hamam, K., Zs, M., Boroojerdi, B., Giladi, N., Wood, D., Sherman, D., Chaudhuri, R., Partinen, M., Abdo, F., Bloem, B., Kremer, B., Verbeek, M., Cronlein, T., Mueller, U., Hajak, G., Zulley, J., Namba, K., Li, L., Mtsuura, M., Kaneita, Y., Ohida, T., Cappeliez, B., Moutrier, R., De, S., Dwivedi, S., Chambers, D., Gabbay, E., Watanabe, A., Valle, C., Kauati, A., Watanabe, R., Chediek, F., Botte, S., Azevedo, E., Kempf, J., Cizza, G., Torvik, S., Brancati, G., Smirne, N., Bruni, A., Goff, E., Freilich, S., Malaweera, A., Simonds, A., Mathias, C., Morrell, M., Rinsky, B., Fonarow, G., Gradinger, F. P., Boldt, C., Geyh, S., Stucki, A., Dahlberg, A., Michel, F., Savard, M.-H., Savard, J., Quesnel, C., Hirose, K., Takahara, M., Mizuno, K., Sadachi, H., Nagashima, Y., Yada, Y., Cheung, C.-F., Lau, C., Lai, W., Sin, K., Tam, C., Hellgren, J., Omenaas, E., Gíslason, T., Jögi, R., Franklin, K., Torén, K., Wang, F., Kadono, M., Shigeta, M., Nakazawa, A., Ueda, M., Fukui, M., Hasegawa, G., Yoshikawa, T., de Niet, G., Tiemens, B., Lendemeijer, B., Hutschemaekers, G., Gauthier, A.-K., Chevrette, T., Chevrier, E., Bouvier, H., Parry, B., Meliska, C., Nowakowski, S., Lopez, A., Martinez, F., Sorenson, D., Lien, M. L., Lattova, Z., Maurovich-Horvat, E., Nia, S., Pollmächer, T., Poulin, J., Chouinard, S., Stip, E., Guillem, F., Venne, D., Caouette, M., Lamont, M.-E., Lázár, A., Lázár, Z., Bíró, A., Gyõri, M., Tárnok, Z., Prekop, C., Gádoros, J., Halász, P., Bódizs, R., Okun, M., Hanusa, B., Hall, M., Wisner, K., Pereira, M., Kumar, R. A. J. E. S. H., Macey, P. A. U. L., Woo, M. A. R. Y., Serber, S. T. A. C. Y., Valladares, E. D. W. I. N., Harper, R. E. B. E. C. C. A., Harper, R. O. N. A. L. D., Puttonen, S., Härmä, M., Vahtera, J., Kivimäki, M., Lamarche, L., Hemmeter, U. M., Thum, A., Rocamora, R., Giesler, M., Haag, A., Dodel, R., Krieg, J. C., Shechter, A., L’Esperance, P., Boivin, D. B., Vu, M.-T., and Richards, H.

Published
2007
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13. The Dutch Y-chromosomal landscape

Author

Altena, E, Smeding, R, van der Gaag, KJ, Larmuseau, MHD, Decorte, R, Lao Grueso, Oscar, Kayser, Manfred, Kraaijenbrink, T, de Knijff, P, Altena, E, Smeding, R, van der Gaag, KJ, Larmuseau, MHD, Decorte, R, Lao Grueso, Oscar, Kayser, Manfred, Kraaijenbrink, T, and de Knijff, P

Published
2020

20. The Dutch Y-chromosomal landscape

Author

Altena, E. (Eveline), Smeding, R. (Risha), Gaag, K. (Kristiaan) van der, Larmuseau, M.H.D. (Maarten), Decorte, R. (Ronny), Lao Grueso, O. (Oscar), Kayser, M.H. (Manfred), Kraaijenbrink, T. (Thirsa), Knijff, P. (Peter) de, Altena, E. (Eveline), Smeding, R. (Risha), Gaag, K. (Kristiaan) van der, Larmuseau, M.H.D. (Maarten), Decorte, R. (Ronny), Lao Grueso, O. (Oscar), Kayser, M.H. (Manfred), Kraaijenbrink, T. (Thirsa), and Knijff, P. (Peter) de

Abstract

Previous studies indicated existing, albeit limited, genetic-geographic population substructure in the Dutch population based on genome-wide data and a lack of this for mitochondrial SNP based data. Despite the aforementioned studies, Y-chromosomal SNP data from the Netherlands remain scarce and do not cover the territory of the Netherlands well enough to allow a reliable investigation of genetic-geographic population substructure. Here we provide the first substantial dataset of detailed spatial Y-chromosomal haplogroup information in 2085 males collected across the Netherlands and supplemented with previously published data from northern Belgium. We found Y-chromosomal evidence for genetic–geographic population substructure, and several Y-haplogroups demonstrating significant clinal frequency distributions in different directions. By means of prediction surface maps we could visualize (complex) distribution patterns of individual Y-haplogroups in detail. These results highlight the value of a micro-geographic approach and are of great use for forensic and epidemiological investigations and our understanding of the Dutch population history. Moreover, the previously noted absence of genetic-geographic population substructure in the Netherlands based on mitochondrial DNA in contrast to our Y-chromosome results, hints at different population histories for women and men in the Netherlands.

Published
2019
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23. The Beaker Phenomenon and the genomic transformation of Northwest Europe

Author

Olalde, I., Brace, S., Allentoft, M., Armit, I., Kristiansen, K., Rohland, N., Mallick, S., Booth, T., Szécsényi-Nagy, A., Mittnik, A., Altena, E., Lipson, M., Lazaridis, I., Patterson, N., Broomandkhoshbacht, N., Diekmann, Y., Faltyskova, Z., Fernandes, D., Ferry, M., Harney, E., de Knijff, P., Michel, M., Oppenheimer, J., Stewardson, K., Barclay, A., Alt, K., Fernández, A., Bánffy, E., Bernabò-Brea, M., Billoin, D., Blasco, C., Bonsall, C., Bonsall, L., Allen, T., Büster, L., Carver, S., Navarro, L., Craig, O., Cook, G., Cunliffe, B., Denaire, A., Dinwiddy, K., Dodwell, N., Ernée, M., Evans, C., Kuchařík, M., Farré, J., Fokkens, H., Fowler, C., Gazenbeek, M., Pena, R., Haber-Uriarte, M., Haduch, E., Hey, G., Jowett, N., Knowles, T., Massy, K., Pfrengle, S., Lefranc, P., Lemercier, O., Lefebvre, A., Maurandi, J., Majó, T., McKinley, J., McSweeney, K., Gusztáv, M., Modi, A., Kulcsár, G., Kiss, V., Czene, A., Patay, R., Endródi, A., Köhler, K., Hajdu, T., Cardoso, J., Liesau, C., Pearson, M., Włodarczak, P., Price, T., Prieto, P., Rey, P., Ríos, P., Risch, R., Guerra, M., Schmitt, A., Serralongue, J., Silva, A., Smrčka, V., Vergnaud, L., Zilhão, J., Caramelli, D., Higham, T., Heyd, V., Sheridan, A., Sjögren, K., Thomas, M., Stockhammer, P., Pinhasi, R., Krause, J., Haak, W., Barnes, I., Lalueza-Fox, C., and Reich, D.

Published
2017

32. Merovingers in een villa 2 : romeinse villa en merovingisch grafveld Borgharen - Pasestraat : onderzoek 2012

Author

Lauwerier, Roel C.G.M., Kort, Jan Willem de, Altena, E., Brandenburgh, C.R., Brinkkemper, Otto, Deeben, Jos H.C., Groot, Tessa de, Hendriks, J., Huisman, Hans D.J., Jagt, Inge M.M. van der, Kars, M., Knijff, P. de, Kootker, Lisette M., Kuijper, W.J., Laarman, Frits J., Meijvogel, E., Muller, S.A., Ngan-Tillard, Dominique J.M., Nieman, A.M., Os, Bertil J.H. van, Panhuysen, R.G.A.M., Rooijen, Cees A.M. van, Roomberg, P., Smeding, M., Soeters, G.C., Theunissen, Liesbeth, Theuws, Frans C.W.J., Tolboom, Hendrik Jan, Verwaal. W., Vogelzang, R.M., Zwaan, J.C., R.C.G.M. Lauwerier en J.W. de Kort (red.), auteurs: E Altena ... [et al.], and Rijksdienst voor Archeologie, Cultuurlandschap en Monumenten

Subjects
Romeinse tijd, villa's, Archaeology, Merovingische tijd, grafvelden, archeologie
Abstract

Met lit.opg. en bijl.

Published
2014

33. Het Merovingisch grafveld

Author

Lauwerier, R.C.G.M., de Kort, J.W., Altena, E., Brandenburgh, C.R., Hendriks, J., van der Jagt, I.M.M., Kars, M., Kootker, L.M., Panhuysen, R.G.A.M., Lauwerier, R.C.G.M, and Art and Culture, History, Antiquity

Published
2014

34. Mesolitische man uit de Noordzee

Author

Storm, P., Altena, E., van der Kolk, T., Kootker, L.M., Mol, D., Post, K., and Geology and Geochemistry

Published
2014

37. Imaging causes and consequences of insomnia and sleep complaints

Author

van Someren, E.J.W., Altena, E., Ramauter, J.R., Stoffers, D., Benjamins, J.S., Moens, S., Hoo, E.Y., Hong, S.B., van der Werf, Y.D., Nofzinger, E., Maquet, P., Thorpy, M.J., Integrative Neurophysiology, and Neuroscience Campus Amsterdam - Neurobiology of Mental Health

Published
2013

38. Een knekelveld maakt geschiedenis : het archeologisch onderzoek van het koor en het grafveld van de middeleeuwse Catharinakerk in Eindhoven, circa 1200-1850

Author

Arts, Nico, Altena, E., redactie: Nico Arts, met bijdragen van: Eveline Altena, Nico Arts, Steffen Baetsen, Ben van den Broek, Kinie Esser, Candice Johns, Peter de Knijff, Marga Lambregtse, Jan Melssen, Joeske Nollen, Jan Pelsdonk, Risha Smeding, Maaike Sonders, Jakob Wallinga, Leonie Weterings-Korthorst, and Uitgeverij Matrijs

Subjects
Kerkgebouwen, Organisch materiaal, Anorganisch materiaal, Archaeology, grafvelden, Skeletonderzoek, Nieuwe tijd, Archeologisch onderzoek, Late middeleeuwen, archeologie
Abstract

Uitgave in samenwerking met de gemeente Einhoven, afdeling Stedenbouw

Published
2013

40. Stroop Kleur-Woord Test (Stroop KWT)

Author

Bouma, J.M., Mulder, Jacqueline, Altena, E., Schmand, B, Lindeboom, J, Mulder, J., Lindeboom, J., Schmand, B., Neuropsychology across the Life-Span, and Experimental Psychotherapy & Psychopathology

Published
2012

41. Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning

Author

van der Werf, Y.D., Altena, E., Vis, J.C., Koene, T., van Someren, E.J.W., Anatomy and neurosciences, Neurology, NCA - Attention & Cognition, Medical psychology, Netherlands Institute for Neuroscience (NIN), Integrative Neurophysiology, and Neuroscience Campus Amsterdam - Attention & Cognition

Subjects
behavioral disciplines and activities, psychological phenomena and processes
Abstract

Total sleep deprivation in healthy subjects has a profound effect on the performance on tasks measuring sustained attention or vigilance. We here report how a selective disruption of deep sleep only, that is, selective slow-wave activity (SWA) reduction, affects the performance of healthy well-sleeping subjects on several tasks: a " simple" and a " complex" vigilance task, a declarative learning task, and an implicit learning task despite unchanged duration of sleep.We used automated electroencephalogram (EEG) dependent acoustic feedback aimed at selective interference with-and reduction of-SWA. In a within-subject repeated measures crossover design, performance on the tasks was assessed in 13 elderly adults without sleep complaints after either SWA-reduction or after normal sleep.The number of vigilance lapses increased as a result of SWA reduction, irrespective of the type of vigilance task. Recognition on the declarative memory task was also affected by SWA reduction, associated with a decreased activation of the right hippocampus on encoding (measured with fMRI) suggesting a weaker memory trace. SWA reduction, however, did not affect reaction time on either of the vigilance tasks or implicit memory task performance.These findings suggest a specific role of slow oscillations in the subsequent daytime ability to maintain sustained attention and to encode novel declarative information but not to maintain response speed or to build implicit memories. Of particular interest is that selective SWA reduction can mimic some of the effects of total sleep deprivation, while not affecting sleep duration. © 2011 Elsevier B.V.

Published
2011
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46. Do sleep complaints contribute to age-related cognitive decline?

Author

Altena, E., Ramautar, J.R., van der Werf, Y.D., van Someren, E.J.W., Neuroscience Campus Amsterdam - Neurodegeneration, Neuroscience Campus Amsterdam - Brain Imaging, Neuroscience Campus Amsterdam - Attention & Cognition, Neurology, Anatomy and neurosciences, Medical psychology, NCA - Brain Imaging, NCA - Attention & Cognition, NCA - Neurodegeneration, and Netherlands Institute for Neuroscience (NIN)

Subjects
SDG 16 - Peace, SDG 16 - Peace, Justice and Strong Institutions, Justice and Strong Institutions
Abstract

The cognitive changes that occur with ageing are usually referred to as 'age-related cognitive decline'. The most pronounced changes may be found in the executive functions that require integrity of the prefrontal cortical circuitry. With age, sleep also changes profoundly, with more sleep fragmentation, earlier awakenings and less slow wave sleep as its main features. Interestingly, experimental sleep deprivation studies in healthy young adults showed a particularly consistent effect on executive functions, suggesting that sleep problems might contribute to the cognitive changes accompanying older age. We here investigate this possibility by reviewing reports on age-related and insomnia-related changes in cognition and brain function and structure, as found in studies investigating subjective complaints, objective functioning in everyday life, neuropsychological assessment, psychometry, structural and functional magnetic resonance imaging, electroencephalography, positron emission tomography and transcranial magnetic stimulation. The chapter focuses on the 'normal' age-related sleep changes that are experienced as insomnia - that is, fragmentation of sleep, more superficial sleep, more wake after sleep onset and earlier awakenings - rather than on specific sleep disturbances as sleep-disordered breathing, restless legs or periodic limb movements during sleep, for all of which the risk increases with age. It turned out that relatively few studies directly addressed the question whether elderly with different degrees of sleep complaints are differentially affected by 'age-related cognitive decline'. Still, several similarities between age-related and insomnia-related cognitive and brain changes are apparent, notably with respect to performance requiring integrity of the prefrontal cortical system. We suggest that at least part of what we regard as age-related changes may, in fact, be due to poor sleep, which is in some cases a treatable condition. Further research directly comparing aged good sleepers versus aged insomniacs will need to elucidate how sleep disturbances are involved in the cognitive, structural and functional changes observed with increasing age. The findings suggest that discrimination of subtypes of poor sleep at high age will aid in understanding the mechanisms by which it affects cognition and brain function. © 2010 Elsevier B.V.

Published
2010
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47. Prefrontal involvement related to cognitive impairment in progressive muscular atrophy

Author

Raaphorst, J., Tol, M.J. van, Groot, P.F.M., Altena, E., Werf, Y.D. van der, Majoie, C.B., Kooi, A.J. van der, Berg, L.H. van den, Schmand, B.A., Visser, M de, Veltman, D.J., Raaphorst, J., Tol, M.J. van, Groot, P.F.M., Altena, E., Werf, Y.D. van der, Majoie, C.B., Kooi, A.J. van der, Berg, L.H. van den, Schmand, B.A., Visser, M de, and Veltman, D.J.

Abstract

Item does not contain fulltext, OBJECTIVE: To examine brain activation patterns during verbal fluency performance in patients with progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS). METHODS: fMRI was used to examine the blood oxygen level-dependent response during letter and category fluency performance in 18 patients with PMA, 21 patients with ALS, and 17 healthy control subjects, matched for age and education. fMRI results are reported at p < 0.05, family-wise error (FWE)-corrected for multiple comparisons. We analyzed effects of performance, age-related white matter changes (ARWMC), and regional brain volumes; all participants underwent neuropsychological investigation. RESULTS: Disease duration of patients with PMA (mean 26.0 months, SD 13.6) and ALS (22.2 months, SD 11.4) was comparable. Patients with PMA and ALS had mild to moderate disease severity and showed impaired letter fluency compared with controls. Between-group analysis showed a main effect of group in the left inferior frontal gyrus (IFG, Brodmann area 45) during letter fluency, which was unaffected by performance, ARWMC, and IFG volume: patients with PMA showed lower activation than controls but higher than that of patients with ALS (ALS < PMA < healthy controls; pFWE = 0.035; z score 4.11; cluster size = 11). A more caudal region in the IFG showed lower activation in patients with PMA than controls during letter fluency performance (post hoc test; pFWE = 0.026). No activation differences were observed during the category fluency task. CONCLUSION: Prefrontal activation abnormalities are related to an important clinical measure of executive dysfunction in patients with motor neuron disease with and without upper motor neuron signs.

Published
2014

48. G.P.290

Author

Raaphorst, J., primary, van Tol, M.J., additional, de Groot, P.F.C., additional, Altena, E., additional, van der Werf, Y.D., additional, Majoie, C.B., additional, van der Kooi, A.J., additional, van den Berg, L.H., additional, Schmand, B.A., additional, de Visser, M., additional, and Veltman, D.J., additional

Published
2014
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50. Clinal distribution of human genomic diversity across the Netherlands despite archaeological evidence for genetic discontinuities in Dutch population history

Author

Lao Grueso, O. (Oscar), Altena, E. (Eveline), Becker, C.R. (Christian), Brauer, S. (Silke), Kraaijenbrink, T. (Thirsa), Oven, M. (Mannis) van, Nürnberg, P. (Peter), Knijff, P. (Peter) de, Kayser, M.H. (Manfred), Lao Grueso, O. (Oscar), Altena, E. (Eveline), Becker, C.R. (Christian), Brauer, S. (Silke), Kraaijenbrink, T. (Thirsa), Oven, M. (Mannis) van, Nürnberg, P. (Peter), Knijff, P. (Peter) de, and Kayser, M.H. (Manfred)

Abstract

Background: The presence of a southeast to northwest gradient across Europe in human genetic diversity is a well-established observation and has recently been confirmed by genome-wide single nucleotide polymorphism (SNP) data. This pattern is traditionally explained by major prehistoric human migration events in Palaeolithic and Neolithic times. Here, we investigate whether (similar) spatial patterns in human genomic diversity also occur on a micro-geographic scale within Europe, such as in the Netherlands, and if so, whether these patterns could also be explained by more recent demographic events, such as those that occurred in Dutch population history.Methods: We newly collected data on a total of 999 Dutch individuals sampled at 54 sites across the country at 443,816 autosomal SNPs using the Genome-Wide Human SNP Array 5.0 (Affymetrix). We studied the individual genetic relationships by means of classical multidimensional scaling (MDS) using different genetic distance matrices, spatial ancestry analysis (SPA), and ADMIXTURE software. We further performed dedicated analyses to search for spatial patterns in the genomic variation and conducted simulations (SPLATCHE2) to provide a historical interpretation of the observed spatial patterns.Results: We detected a subtle but clearly noticeable genomic population substructure in the Dutch population, allowing differentiation of a north-eastern, central-western, central-northern and a southern group. Furthermore, we observed a statistically significant southeast to northwest cline in the distribution of genomic diversity across the Netherlands, similar to earlier findings from across Europe. Simulation analyses indicate that this genomic gradient could similarly be caused by ancient as well as by the more recent events in Dutch history.Conclusions: Considering the strong archaeological evidence for genetic discontinuity in the Netherlands, we interpret the observed clinal pattern of genomic diversity as being caused by r

Published
2013
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