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2. Teaching Sciences and Mathematics -- A Challenge for Higher Education Institutions: A Systematic Review

Author

Vedrenne-Gutiérrez, Fernand, Altamirano-Bustamante, Myriam M., Monroy-Fraustro, Daniela, de Hoyos Bermea, Adalberto, and Lopez-Suero, Carolina

Abstract

The current job market requires scientifically literate human resources. At a time in which scientific reasoning should be part of the higher education curriculum, the general population is pulling away from it. This review aims to identify how students' and teachers' attitudes and values influence academic performance in science courses. PICO and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approaches were used to explore four databases and 6488 articles were retrieved. Articles had to be relevant to the research question and published within the last 10 years. Articles without an identifiable author or articles unrelated to the research question were excluded. Following three rounds of quality screening, 10 articles were finally selected for analysis. Study designs and quality varied across the selected articles. Self-efficacy, having mastery goals, perceiving the course as valuable, and having a student identity were consistently associated with good learning outcomes. Cooperation was found to increase task value and autonomy when taking science courses; conversely, a performance approach and a consumer identity were negatively correlated with good learning outcomes. In the past 10 years, there was paucity in research studying the role of teacher attitudes towards science courses on learning outcomes. This article proposes a hypothetical model that describes how attitudes and values may lead to mastery and a good academic performance in undergraduate science courses. With this model, we seek to enhance and strengthen the nature and scope of science education in universities.

Published
2021
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3. Unpacking the aggregation-oligomerization-fibrillization process of naturally-occurring hIAPP amyloid oligomers isolated directly from sera of children with obesity or diabetes mellitus

Author

Altamirano-Bustamante, Myriam M., Altamirano-Bustamante, Nelly F., Larralde-Laborde, Mateo, Lara-Martínez, Reyna, Leyva-García, Edgar, Garrido-Magaña, Eulalia, Rojas, Gerardo, Jiménez-García, Luis Felipe, Revilla-Monsalve, Cristina, Altamirano, Perla, and Calzada-León, Raúl

Published
2019
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4. Revisión de modelos para el análisis de dilemas éticos

Author

Ruíz-Cano, Jennifer, Cantú-Quintanilla, Guillermo R., Ávila-Montiel, Diana, Gamboa-Marrufo, José Domingo, Juárez-Villegas, Luis E., de Hoyos-Bermea, Adalberto, Chávez-López, Adrián, Estrada-Ramírez, Karla P., Merelo-Arias, Carlos A., Altamirano-Bustamante, Myriam M., de la Vega-Morell, Nahum, Peláez-Ballestas, Ingris, Guadarrama-Orozco, Jessica H., Muñoz-Hernández, Onofre, and Garduño-Espinosa, Juan

Published
2015
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5. Protein Science Meets Artificial Intelligence: A Systematic Review and a Biochemical Meta-Analysis of an Inter-Field

Author

Villalobos-Alva, Jalil, primary, Ochoa-Toledo, Luis, additional, Villalobos-Alva, Mario Javier, additional, Aliseda, Atocha, additional, Pérez-Escamirosa, Fernando, additional, Altamirano-Bustamante, Nelly F., additional, Ochoa-Fernández, Francine, additional, Zamora-Solís, Ricardo, additional, Villalobos-Alva, Sebastián, additional, Revilla-Monsalve, Cristina, additional, Kemper-Valverde, Nicolás, additional, and Altamirano-Bustamante, Myriam M., additional

Published
2022
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6. ¿Qué hacer en casos de niños que requieren tratamientos no autorizados por padres por cuestiones religiosas?

Author

Quintanilla, Guillermo R., primary, Guadarrama-Orozco, Jéssica H., additional, Altamirano- Bustamante, Myriam M., additional, Peláez-Ballestas, Ingrid, additional, Juárez-Villegas, Luis E., additional, de la Vega- Morell, Nahúm, additional, Kelly-García, Javier, additional, de Hoyos-Bermea, Adalberto, additional, Caballero- Velarde, Ma. Cristina, additional, Ávila-Montiel, Diana, additional, Gamboa-Marrufo, José D., additional, Muñoz-Hernández, Onofre, additional, and Garduño-Espinosa, Juan, additional

Published
2022
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12. Bibliotherapy as a Non-pharmaceutical Intervention to Enhance Mental Health in Response to the COVID-19 Pandemic: A Mixed-Methods Systematic Review and Bioethical Meta-Analysis

Author

Monroy-Fraustro, Daniela, primary, Maldonado-Castellanos, Isaac, additional, Aboites-Molina, Mónica, additional, Rodríguez, Susana, additional, Sueiras, Perla, additional, Altamirano-Bustamante, Nelly F., additional, de Hoyos-Bermea, Adalberto, additional, and Altamirano-Bustamante, Myriam M., additional

Published
2021
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17. Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes

Author

Altamirano-Bustamante, Nelly F., primary, Garrido-Magaña, Eulalia, additional, Morán, Eugenia, additional, Calderón, Aurora, additional, Pasten-Hidalgo, Karina, additional, Castillo-Rodríguez, Rosa Angélica, additional, Rojas, Gerardo, additional, Lara-Martínez, Reyna, additional, Leyva-García, Edgar, additional, Larralde-Laborde, Mateo, additional, Domíguez, Guadalupe, additional, Murata, Chiharu, additional, Margarita-Vazquez, Yolanda, additional, Payro, Rafael, additional, Barbosa, Manuel, additional, Valderrama, Alejandro, additional, Montesinos, Hortencia, additional, Domínguez-Camacho, Alejandra, additional, García-Olmos, Víctor H., additional, Ferrer, Regina, additional, Medina-Bravo, Patricia G., additional, Santoscoy, Fernanda, additional, Revilla-Monsalve, Cristina, additional, Jiménez-García, Luis Felipe, additional, Morán, Julio, additional, Villalobos-Alva, Jalil, additional, Villalobos, Mario Javier, additional, Calzada-León, Raúl, additional, Altamirano, Perla, additional, and Altamirano-Bustamante, Myriam M., additional

Published
2020
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18. Novel insight into streptozotocin-induced diabetic rats from the protein misfolding perspective

Author

Leyva-García, Edgar, primary, Lara-Martínez, Reyna, additional, Morán-Zanabria, Liborio, additional, Revilla-Monsalve, Cristina, additional, Jiménez-García, Luis Felipe, additional, Oviedo, Norma, additional, Murata, Chiharu, additional, Garrido-Magaña, Eulalia, additional, Altamirano-Bustamante, Nelly F., additional, and Altamirano-Bustamante, Myriam M., additional

Published
2017
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19. Today´s medical self and the other: Challenges and evolving solutions for enhanced humanization and quality of care

Author

Sueiras, Perla, primary, Romano-Betech, Victoria, additional, Vergil-Salgado, Alejandro, additional, de Hoyos, Adalberto, additional, Quintana-Vargas, Silvia, additional, Ruddick, William, additional, Castro-Santana, Anaclara, additional, Islas-Andrade, Sergio, additional, Altamirano-Bustamante, Nelly F., additional, and Altamirano-Bustamante, Myriam M., additional

Published
2017
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20. Bioética en tiempo real: El Límite de la viabilidad en los recién nacidos

Author

Zamorano Jiménez, Clara Aurora, Chirino-Barceló, Yazmin, Baptista González, Héctor Alfredo, and Altamirano Bustamante, Myriam M

Subjects
Ethics, Recién Nacidos, Prematuros, Ética, Viabilidad Fetal, Fetal viability, Premature newborns
Abstract

Introducción: los avances en la medicina perinatal en sociedades con mayor desarrollo industrial, han generado reducción en las tasas de mortalidad neonatal con una gradual disminución en la edad gestacional con posibilidades de supervivencia. Objetivo: analizar los elementos bioéticos considerados en la toma de decisiones para establecer los límites de viabilidad en el recién nacido. Metodología: se realizó una búsqueda bibliográfica en distintas fuentes y bases de datos electrónicas sobre los aspectos éticos, legal y humanista en relación con el límite de la viabilidad en los recién nacidos. Resultados y conclusiones: se describen dos escenarios clínicos, que son la plataforma para ejemplificar e iniciar el análisis del dilema ético que condiciona el límite de la viabilidad; se discute la zona gris de la neonatología de acuerdo a tasas de sobrevivencia y tasas de mortalidad en distintos países con diferentes características, dividiéndolos en países desarrollados o subdesarrollados. Se realiza el análisis bioético del dilema, en base a las teorías éticas y modelos de discernimiento: teorías utilitarista, deontológica y aretológica. (MÉD UIS.2013;26(3):23-31) IAdvances in perinatal medicine over the past decades have led to reduced rates in neonatal mortality with a gradual decrease in gestational age with chances of survival. The aim of this review is to analyze the elements considered in bioethical decision making to establish the limits of viability in the newborn infant. A literature search was conducted in different sources and electronic databases on different ethics, legal and humanitarian aspects in relation to the limit of neonatal viability. We describe two clinical scenarios, which are the platform to start the analysis of the ethical dilemma that determines the limit of viability. We discuss the "gray zone" of neonatology according to survival and mortality rates in different countries with distinctive characteristics, dividing them into developed and developing countries. Bioethical analysis is performed of the dilemma, based on ethical theories and models of judgment: utilitarian, deontological and aretological theories. (MÉD UIS.2013;26(3):23-31)

Published
2013

21. Drug Development in Conformational Diseases: A Novel Family of Chemical Chaperones that Bind and Stabilise Several Polymorphic Amyloid Structures

Author

Sablón-Carrazana, Marquiza, primary, Fernández, Isaac, additional, Bencomo, Alberto, additional, Lara-Martínez, Reyna, additional, Rivera-Marrero, Suchitil, additional, Domínguez, Guadalupe, additional, Pérez-Perera, Rafaela, additional, Jiménez-García, Luis Felipe, additional, Altamirano-Bustamante, Nelly F., additional, Diaz-Delgado, Massiel, additional, Vedrenne, Fernand, additional, Rivillas-Acevedo, Lina, additional, Pasten-Hidalgo, Karina, additional, Segura-Valdez, María de Lourdes, additional, Islas-Andrade, Sergio, additional, Garrido-Magaña, Eulalia, additional, Perera-Pintado, Alejandro, additional, Prats-Capote, Anaís, additional, Rodríguez-Tanty, Chryslaine, additional, and Altamirano-Bustamante, Myriam M., additional

Published
2015
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22. Diabetes Drug Discovery: hIAPP1–37 Polymorphic Amyloid Structures as Novel Therapeutic Targets.

Author

Fernández-Gómez, Isaac, Sablón-Carrazana, Marquiza, Bencomo-Martínez, Alberto, Domínguez, Guadalupe, Lara-Martínez, Reyna, Altamirano-Bustamante, Nelly F., Jiménez-García, Luis Felipe, Pasten-Hidalgo, Karina, Castillo-Rodríguez, Rosa Angélica, Altamirano, Perla, Marrero, Suchitil Rivera, Revilla-Monsalve, Cristina, Valdés-Sosa, Peter, Salamanca-Gómez, Fabio, Garrido-Magaña, Eulalia, Rodríguez-Tanty, Chryslaine, and Altamirano-Bustamante, Myriam M.

Abstract

Human islet amyloid peptide (hIAPP1–37) aggregation is an early step in Diabetes Mellitus. We aimed to evaluate a family of pharmaco-chaperones to act as modulators that provide dynamic interventions and the multi-target capacity (native state, cytotoxic oligomers, protofilaments and fibrils of hIAPP1–37) required to meet the treatment challenges of diabetes. We used a cross-functional approach that combines in silico and in vitro biochemical and biophysical methods to study the hIAPP1–37 aggregation-oligomerization process as to reveal novel potential anti-diabetic drugs. The family of pharmaco-chaperones are modulators of the oligomerization and fibre formation of hIAPP1–37. When they interact with the amino acid in the amyloid-like steric zipper zone, they inhibit and/or delay the aggregation-oligomerization pathway by binding and stabilizing several amyloid structures of hIAPP1–37. Moreover, they can protect cerebellar granule cells (CGC) from the cytotoxicity produced by the hIAPP1–37 oligomers. The modulation of proteostasis by the family of pharmaco-chaperones A–F is a promising potential approach to limit the onset and progression of diabetes and its comorbidities. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review.

Author

Avila-Vazquez, Maria Fernanda, Altamirano-Bustamante, Nelly F., and Altamirano-Bustamante, Myriam M.

Subjects
AMYLOID, PROTEOMICS, BIOLOGICAL tags, ALZHEIMER'S disease, OLIGOMERS, ENZYME-linked immunosorbent assay
Abstract

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Fe de errores de “Revisión de modelos para el análisis de dilemas éticos”

Author

Ruíz-Cano, Jennifer, primary, Cantú-Quintanilla, Guillermo R., additional, Ávila-Montiel, Diana, additional, Gamboa-Marrufo, José Domingo, additional, Juárez-Villegas, Luis E., additional, de Hoyos-Bermea, Adalberto, additional, Chávez-López, Adrián, additional, Estrada-Ramírez, Karla P., additional, Merelo-Arias, Carlos A., additional, Altamirano-Bustamante, Myriam M., additional, de la Vega-Morell, Nahum, additional, Peláez-Ballestas, Ingris, additional, Guadarrama-Orozco, Jessica H., additional, Muñoz-Hernández, Onofre, additional, and Garduño-Espinosa, Juan, additional

Published
2015
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25. Diabetes mellitus as a conformational disease: a novel potential therapeutic approach

Author

Fernandez-Gomez, Isaac, primary, Sablon-Carrazana, Marquiza, additional, Bencomo, Alberto, additional, Pasten-Hidalgo, Karina, additional, Castillo-Rodriguez, Rosa Angelica, additional, Dominguez, Guadalupe, additional, Lara, Reyna, additional, Jimenez, Luis Felipe, additional, Moran, Julio, additional, Altamirano-Bustamante, Nelly, additional, Islas-Andrade, Sergio, additional, Rodriguez-Tanty, Chryslaine, additional, Garrido-Magana, Eulalia, additional, and Altamirano-Bustamante, Myriam M, additional

Published
2015
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27. Novel ethical dilemmas arising in geriatric clinical practice

Author

Calleja-Sordo, Elisa Constanza, primary, de Hoyos, Adalberto, additional, Méndez-Jiménez, Jorge, additional, Altamirano-Bustamante, Nelly F., additional, Islas-Andrade, Sergio, additional, Valderrama, Alejandro, additional, García-Peña, Carmen, additional, and Altamirano-Bustamante, Myriam M., additional

Published
2014
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28. Cardiovascular medicine at face value: a qualitative pilot study on clinical axiology

Author

de Hoyos, Adalberto, primary, Nava-Diosdado, Rodrigo, additional, Mendez, Jorge, additional, Ricco, Sergio, additional, Serrano, Ana, additional, Flores Cisneros, Carmen, additional, Macías-Ojeda, Carlos, additional, Cisneros, Héctor, additional, Bialostozky, David, additional, Altamirano-Bustamante, Nelly, additional, and Altamirano-Bustamante, Myriam M, additional

Published
2013
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29. Promoting networks between evidence-based medicine and values-based medicine in continuing medical education

Author

Altamirano-Bustamante, Myriam M, primary, Altamirano-Bustamante, Nelly F, additional, Lifshitz, Alberto, additional, Mora-Magaña, Ignacio, additional, de Hoyos, Adalberto, additional, Ávila-Osorio, María Teresa, additional, Quintana-Vargas, Silvia, additional, Aguirre, Jorge A, additional, Méndez, Jorge, additional, Murata, Chiharu, additional, Nava-Diosdado, Rodrigo, additional, Martínez-González, Oscar, additional, Calleja, Elisa, additional, Vargas, Raúl, additional, Mejía-Arangure, Juan Manuel, additional, Cortez-Domínguez, Araceli, additional, Vedrenne-Gutiérrez, Fernand, additional, Sueiras, Perla, additional, Garduño, Juan, additional, Islas-Andrade, Sergio, additional, Salamanca, Fabio, additional, Kumate-Rodríguez, Jesús, additional, and Reyes-Fuentes, Alejandro, additional

Published
2013
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30. Reexamining Healthcare Justice in the Light of Empirical Data.

Author

Hoyos, Adalberto, Monteón, Yareni, and Altamirano‐Bustamante, Myriam M.

Subjects
ATTITUDE (Psychology), COMMUNICATIVE competence, COMPARATIVE studies, DECISION making, HUMAN rights, INTERVIEWING, LONGITUDINAL method, RESEARCH methodology, MEDICAL care, MEDICAL ethics, MEDICAL personnel, PATIENT-professional relations, SCIENTIFIC observation, LEGAL status of patients, TRUST, DATA analysis software, PATIENTS' attitudes
Abstract

This article discusses the notion of justice from a capabilities approach. We undertake an empirical analysis of the concepts of justice held by healthcare personnel, gleaned from a qualitative analysis of interviews on the subject of ethical dilemmas in everyday practice. The article states that Justice undoubtedly presents a work in progress, which implicates the link between justice as capability and human dignity. We empirically found a contrast between the views of justice based on the patient's own perceptions and those based on the perceptions of healthcare personnel. We establish the kind of actions, communication skills and justice required to build a stronger relationship between patients and healthcare professionals, which would improve prognosis, treatment efficiency and therapeutic adhesion. [ABSTRACT FROM AUTHOR]

Published
2015
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32. Evaluación del crecimiento: estado nutricional.

Author

Altamirano-Bustamante, Nelly F., Altamirano-Bustamante, Myriam M., Valderrama-Hernández, Alejandro, and Montesinos-Correa, Hortencia

Subjects
*CHILD nutrition, *PREVENTION of childhood obesity, *CHILD development, *MALNUTRITION in children, *BODY weight, *PARAMETERS (Statistics), *PREVENTION
Published
2014
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33. La evaluación del crecimiento.

Author

Altamirano-Bustamante, Nelly F., Altamirano-Bustamante, Myriam M., Valderrama-Hernández, Alejandro, and Montesinos-Correa, Hortencia

Published
2014

34. Del proteoma humano a la medicina transfuncional personalizada.

Author

Altamirano Bustamante, Myriam M., Altamirano Bustamante, Nelly F., Espinosa, Juan Garduño, Hernández, Onofre Muñoz, López, Javier Torres, and Bustamante, Eréndira Altamirano

Subjects
*HUMAN genetics, *MEDICAL publishing, *DIGNITY, *VIRTUES, *DIAGNOSIS, *THERAPEUTICS, *PROTEINS
Published
2010

35. Consentimiento informado en grupos vulnerables: participación de niños y adolescentes en protocolos de investigación.

Author

Bustamante, Nelly Altamirano, Bustamante, Eréndira Altamirano, Vargas, Alberto Olaya, de Rubens, Jesús, de la Puente, Silvestre García, and Altamirano Bustamante, Myriam M.

Subjects
INFORMED consent (Medical law), AUTONOMY (Psychology), CHILD psychology, ADOLESCENT psychology, DECISION making in children, PHYSICIAN-patient relations, MEDICAL practice
Published
2010

36. ¿Cómo prepararnos para la deliberación ética en la práctica clínica en pediatría?

Author

Altamirano Bustamante, Nelly F., Aguirre, Alfredo Bobadilla, Bustamante, Eréndira Altamirano, Espinosa, Juan Garduño, Ávila Osorio, María Teresa, Hernández, Onofre Muñoz, Pavon, Rafael García, and Altamirano Bustamante, Myriam M.

Subjects
MEDICAL ethics, DECISION making in children, MEDICAL practice, EVIDENCE-based medicine, BIOETHICS, MEDICAL publishing
Published
2010

37. Economic Family Burden of Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus.

Author

Altamirano-Bustamante, Nelly, Islas-Ortega, Laura, Robles-Valdés, Carlos, Garduño-Espinosa, Juan, Morales-Cisneros, Gabriela, Valderrama, Alejandro, Calzada-León, Raúl, Cuevas, Ma. Luisa, Xancopinca, José Luis, and Altamirano-Bustamante, Myriam M.

Abstract

The article presents information on a study which investigated the economic family burden of metabolic control in children and adolescent with type-1 diabetes mellitus (DM1) at the Instituto Nacional de Pediatria in Mexico City, Mexico. A brief overview is given on DM1 as one of the most frequently encountered chronic metabolic pediatric diseases. The study obtains DM1 family direct costs from a standardized economic survey in children with no chronic severe complications. The study reveals that the highest economic burden was due to self-monitoring of blood glucose and insulin.

Published
2008
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39. Fe de errores de “Revisión de modelos para el análisis de dilemas éticos”.

Author

Ruíz-Cano, Jennifer, Cantú-Quintanilla, Guillermo R., Ávila-Montiel, Diana, Gamboa-Marrufo, José Domingo, Juárez-Villegas, Luis E., de Hoyos-Bermea, Adalberto, Chávez-López, Adrián, Estrada-Ramírez, Karla P., Merelo-Arias, Carlos A., Altamirano-Bustamante, Myriam M., de la Vega-Morell, Nahum, Peláez-Ballestas, Ingris, Guadarrama-Orozco, Jessica H., Muñoz-Hernández, Onofre, and Garduño-Espinosa, Juan

Published
2015
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41. Diabetes Drug Discovery: hIAPP 1-37 Polymorphic Amyloid Structures as Novel Therapeutic Targets.

Author

Fernández-Gómez I, Sablón-Carrazana M, Bencomo-Martínez A, Domínguez G, Lara-Martínez R, Altamirano-Bustamante NF, Jiménez-García LF, Pasten-Hidalgo K, Castillo-Rodríguez RA, Altamirano P, Marrero SR, Revilla-Monsalve C, Valdés-Sosa P, Salamanca-Gómez F, Garrido-Magaña E, Rodríguez-Tanty C, and Altamirano-Bustamante MM

Subjects
Animals, Cell Survival drug effects, Cerebellum pathology, Curcumin chemistry, Curcumin therapeutic use, Diabetes Mellitus pathology, Humans, Islet Amyloid Polypeptide toxicity, Islet Amyloid Polypeptide ultrastructure, Kinetics, Mice, Molecular Docking Simulation, Protein Aggregates, Protein Folding, Protein Multimerization, Rats, Wistar, Amyloid chemistry, Diabetes Mellitus drug therapy, Drug Discovery, Islet Amyloid Polypeptide chemistry, Molecular Targeted Therapy
Abstract

Human islet amyloid peptide (hIAPP 1-37 ) aggregation is an early step in Diabetes Mellitus. We aimed to evaluate a family of pharmaco-chaperones to act as modulators that provide dynamic interventions and the multi-target capacity (native state, cytotoxic oligomers, protofilaments and fibrils of hIAPP 1-37 ) required to meet the treatment challenges of diabetes. We used a cross-functional approach that combines in silico and in vitro biochemical and biophysical methods to study the hIAPP 1-37 aggregation-oligomerization process as to reveal novel potential anti-diabetic drugs. The family of pharmaco-chaperones are modulators of the oligomerization and fibre formation of hIAPP 1-37 . When they interact with the amino acid in the amyloid-like steric zipper zone, they inhibit and/or delay the aggregation-oligomerization pathway by binding and stabilizing several amyloid structures of hIAPP 1-37 . Moreover, they can protect cerebellar granule cells (CGC) from the cytotoxicity produced by the hIAPP 1-37 oligomers. The modulation of proteostasis by the family of pharmaco-chaperones A - F is a promising potential approach to limit the onset and progression of diabetes and its comorbidities., Competing Interests: The author declares having filled two patent applications WO2010118706 A2 and WO2014131374 A1.

Published
2018
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42. Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review.

Author

Avila-Vazquez MF, Altamirano-Bustamante NF, and Altamirano-Bustamante MM

Subjects
Animals, Enzyme-Linked Immunosorbent Assay, Humans, Protein Aggregates, Amyloid metabolism, Biomarkers analysis, Disease, Protein Conformation
Abstract

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones., Competing Interests: The authors declare no conflict of interest.

Published
2017
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43. [Teenager].

Author

Altamirano-Bustamante N and Altamirano-Bustamante MM

Subjects
Adolescent, Adolescent Nutritional Physiological Phenomena, Animals, Bone Density physiology, Calcium metabolism, Calcium, Dietary administration & dosage, Dairy Products, Female, Humans, Male, Milk, Osteoporosis prevention & control, Pregnancy, Pregnancy in Adolescence, Puberty physiology, Vitamin D administration & dosage, Vitamins administration & dosage, Bone Development physiology, Life Style, Minerals metabolism
Abstract

The bone mass peak is the maximum bone quantity to be achieved through bone modeling. About 40% of the total bone mass is achieved at puberty; therefore, adolescence is critical on the skeletal development. This paper is about the transfunctional analysis of nutrition, mineral metabolism, endocrinology and life style in adolescence. Core factors to achieve the maximum potential of bone modeling through puberty and prevent osteoporosis from a pediatric stage are addressed.

Published
2016

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