1. Desferrioxamine-caffeine (DFCAF) as a cell permeant moderator of the oxidative stress caused by iron overload.
- Author
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Alta EC, Goswami D, Machini MT, Silvestre DM, Nomura CS, and Espósito BP
- Subjects
- Antioxidants administration & dosage, Antioxidants pharmacology, Caffeine administration & dosage, Cell Membrane Permeability, Deferoxamine administration & dosage, Drug Evaluation, Preclinical, Ferric Compounds metabolism, Ferric Compounds toxicity, Fluoresceins analysis, Fluorescent Dyes analysis, HeLa Cells, Humans, Iron Chelating Agents administration & dosage, Molecular Structure, Nitrilotriacetic Acid analogs & derivatives, Nitrilotriacetic Acid metabolism, Nitrilotriacetic Acid toxicity, Caffeine pharmacology, Deferoxamine pharmacology, Iron Chelating Agents pharmacology, Iron Overload drug therapy, Oxidative Stress drug effects
- Abstract
Desferrioxamine (DFO) is a potent iron chelator used in the treatment of iron overload (IO) disorders. However, due to its low cell permeability and fast clearance, DFO administration is usually prolonged and of limited use for the treatment of IO in tissues such as the brain. Caffeine is a safe, rapidly absorbable molecule that can be linked to other compounds to improve their cell permeability. In this work, we successfully prepared and described DFO-caffeine, a conjugate with iron scavenging ability, antioxidant properties and enhanced permeation in the HeLa cell model.
- Published
- 2014
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