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1. Textbook outcome in urgent early cholecystectomy for acute calculous cholecystitis: results post hoc of the S.P.Ri.M.A.C.C study

Author

Fugazzola, P, Carbonell-Morote, S, Cobianchi, L, Coccolini, F, Rubio-Garcia, J, Sartelli, M, Biffl, W, Catena, F, Ansaloni, L, Ramia, J, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Agnoletti, V, Bova, R, Convertini, G, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Ciof, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofa, S, Licari, L, Tomasoni, M, Dominioni, T, Fare, C, Maestri, M, Vigano, J, Sargenti, B, Anderloni, A, Musella, V, Frassini, S, Gambini, G, Improta, M, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Landaluce, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Ruta, F, Di Martino, M, Dal Mas, F, Abu-Zidan, F, Di Saverio, S, Leppaniemi, A, Martin-Perez, E, de la Hoz Rodriguez, A, Moore, E, Peitzman, A, Fugazzola P., Carbonell-Morote S., Cobianchi L., Coccolini F., Rubio-Garcia J. J., Sartelli M., Biffl W., Catena F., Ansaloni L., Ramia J. M., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Agnoletti V., Bova R., Convertini G., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Ciof S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofa S., Licari L., Tomasoni M., Dominioni T., Fare C. N., Maestri M., Vigano J., Sargenti B., Anderloni A., Musella V., Frassini S., Gambini G., Improta M., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Landaluce A., Estraviz-Mateos B., Markinez-Gordobil I., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Ruta F., Di Martino M., Dal Mas F., Abu-Zidan F. M., Di Saverio S., Leppaniemi A., Martin-Perez E., de la Hoz Rodriguez A., Moore E. E., Peitzman A. B., Fugazzola, P, Carbonell-Morote, S, Cobianchi, L, Coccolini, F, Rubio-Garcia, J, Sartelli, M, Biffl, W, Catena, F, Ansaloni, L, Ramia, J, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Agnoletti, V, Bova, R, Convertini, G, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Ciof, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofa, S, Licari, L, Tomasoni, M, Dominioni, T, Fare, C, Maestri, M, Vigano, J, Sargenti, B, Anderloni, A, Musella, V, Frassini, S, Gambini, G, Improta, M, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Landaluce, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Ruta, F, Di Martino, M, Dal Mas, F, Abu-Zidan, F, Di Saverio, S, Leppaniemi, A, Martin-Perez, E, de la Hoz Rodriguez, A, Moore, E, Peitzman, A, Fugazzola P., Carbonell-Morote S., Cobianchi L., Coccolini F., Rubio-Garcia J. J., Sartelli M., Biffl W., Catena F., Ansaloni L., Ramia J. M., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Agnoletti V., Bova R., Convertini G., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Ciof S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofa S., Licari L., Tomasoni M., Dominioni T., Fare C. N., Maestri M., Vigano J., Sargenti B., Anderloni A., Musella V., Frassini S., Gambini G., Improta M., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Landaluce A., Estraviz-Mateos B., Markinez-Gordobil I., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Ruta F., Di Martino M., Dal Mas F., Abu-Zidan F. M., Di Saverio S., Leppaniemi A., Martin-Perez E., de la Hoz Rodriguez A., Moore E. E., and Peitzman A. B.

Abstract

Introduction: A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis. Objetive: The objective of this study is to analyze the achievement of TO in patients with urgent early cholecystectomy (UEC) for Acute Cholecystitis. and to identify which factors are related to achieving TO. Materials and methods: This is a post hoc study of the SPRiMACC study. It ́s a prospective multicenter observational study run by WSES. The criteria to define TO in urgent early cholecystectomy (TOUEC) were no 30-day mortality, no 30-day postoperative complications, no readmission within 30 days, and hospital stay ≤ 7 days (75th percentile), and full laparoscopic surgery. Patients who met all these conditions were taken as presenting a TOUEC. Outcomes: 1246 urgent early cholecystectomies for ACC were included. In all, 789 patients (63.3%) achieved all TOUEC parameters, while 457 (36.6%) failed to achieve one or more parameters and were considered non-TOUEC. The patients who achieved TOUEC were younger had significantly lower scores on all the risk scales analyzed. In the serological tests, TOUEC patients had lower values for in a lot of variables than non-TOUEC patients. The TOUEC group had lower rates of complicated cholecystitis. Considering operative time, a shorter duration was also associated with a higher probability of reaching TOUEC. Conclusion: Knowledge of the factors that influence the TOUEC can allow us to improve our results in terms of textbook outcome.

Published
2024

2. Prospective validation of the Israeli Score for the prediction of common bile duct stones in patients with acute calculous cholecystitis

Author

Fugazzola, P, Cobianchi, L, Dal Mas, F, Cicuttin, E, Dominioni, T, Frassini, S, Tomasoni, M, Vigano, J, Catena, F, Ansaloni, L, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Bova, R, Convertini, G, Agnoletti, V, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Cioffi, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofia, S, Licari, L, Anderloni, A, Maestri, M, Fare, C, Sargenti, B, Improta, M, Musella, V, Gambini, G, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Carbonell-Morote, S, Rubio-Garcia, J, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Landaluce-Olavarria, A, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Martin-Perez, E, de la Hoz Rodriguez, A, Di Martino, M, Di Saverio, S, Leppaniemi, A, Moore, E, Peitzman, A, Sartelli, M, Biffl, W, Fugazzola P., Cobianchi L., Dal Mas F., Cicuttin E., Dominioni T., Frassini S., Tomasoni M., Vigano J., Catena F., Ansaloni L., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Bova R., Convertini G., Agnoletti V., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Cioffi S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofia S., Licari L., Anderloni A., Maestri M., Fare C. N., Sargenti B., Improta M., Musella V., Gambini G., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Carbonell-Morote S., Rubio-Garcia J. J., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Estraviz-Mateos B., Markinez-Gordobil I., Landaluce-Olavarria A., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Martin-Perez E., de la Hoz Rodriguez A., Di Martino M., Di Saverio S., Leppaniemi A., Moore E. E., Peitzman A. B., Sartelli M., Biffl W., Fugazzola, P, Cobianchi, L, Dal Mas, F, Cicuttin, E, Dominioni, T, Frassini, S, Tomasoni, M, Vigano, J, Catena, F, Ansaloni, L, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Bova, R, Convertini, G, Agnoletti, V, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Cioffi, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofia, S, Licari, L, Anderloni, A, Maestri, M, Fare, C, Sargenti, B, Improta, M, Musella, V, Gambini, G, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Carbonell-Morote, S, Rubio-Garcia, J, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Landaluce-Olavarria, A, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Martin-Perez, E, de la Hoz Rodriguez, A, Di Martino, M, Di Saverio, S, Leppaniemi, A, Moore, E, Peitzman, A, Sartelli, M, Biffl, W, Fugazzola P., Cobianchi L., Dal Mas F., Cicuttin E., Dominioni T., Frassini S., Tomasoni M., Vigano J., Catena F., Ansaloni L., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Bova R., Convertini G., Agnoletti V., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Cioffi S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofia S., Licari L., Anderloni A., Maestri M., Fare C. N., Sargenti B., Improta M., Musella V., Gambini G., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Carbonell-Morote S., Rubio-Garcia J. J., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Estraviz-Mateos B., Markinez-Gordobil I., Landaluce-Olavarria A., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Martin-Perez E., de la Hoz Rodriguez A., Di Martino M., Di Saverio S., Leppaniemi A., Moore E. E., Peitzman A. B., Sartelli M., and Biffl W.

Abstract

Background: Existing guidelines for predicting common bile duct stones (CBDS) are not specific for acute calculous cholecystitis (ACC). This paper is a posthoc analysis of the S.P.Ri.M.A.C.C study aiming to prospectively validate on a large independent cohort of patients the Israeli Score (IS) in predicting CBDS in patients with ACC. Methods: The S.P.Ri.M.A.C.C. study is an observational multicenter prospective study endorsed by the World Society of Emergency Surgery (WSES). Between September 1st, 2021, and September 1st, 2022, 1201 participants were included. The Chi-Square test was used to compare categorical data. A Cochran-Armitage test was run to determine whether a linear trend existed between the IS and the presence of CBDS. To assess the accuracy of the prediction model, the receiver operating characteristic (ROC) curve was generated, and the area under the ROC curve (AUC) was calculated. Logistic regression was run to obtain Odds Ratio (OR). A two-tailed p < 0.05 was considered statistically significant. Results: The rate of CBDS was 1.8% in patients with an IS of 0, 4.2% in patients with an IS of 1, 24.5% in patients with 2 and 56.3% in patients with 3 (p < 0.001). The Cochran-Armitage test of trend showed a statistically significant linear trend, p < 0.001. Patients with an IS of 3 had 64.4 times (95% CI 24.8–166.9) higher odds of having associated CBDS than patients with an IS of 0. The AUC of the ROC curve of IS for the prediction of CBDS was 0.809 (95% CI 0.752–0.865, p < 0.001). By applying the highest cut-off point (3), the specificity reached 99%, while using the lowest cut-off value (0), the sensitivity reached 100%. Conclusion: The IS is a reliable tool to predict CBDS associated with ACC. The algorithm derived from the IS could optimize the management of patients with ACC.

Published
2023

3. The study of healthcare professionals' perspective towards the quality of diabetic care services in Abha.

Author

EASWARAN, V., KHAN, N. A., IQBAL, M. J., ALSHAHRANI, S. M., ORAYJ, K., ALMELEEBIA, T. M., SADIQ, M. M. J., VIJAYARAGHAVALU, S., and HUSSAIN, A. T. M.

Abstract

OBJECTIVE: The aim of this study was to investigate the relationship between organizational characteristics and diabetes care from the perspective of healthcare professionals (HCPs) in Abha, Kingdom of Saudi Arabia. SUBJECTS AND METHODS: A cross-sectional, self-reported survey of healthcare professionals was done. The study comprised a total of 106 HCPs from various departments involved with diabetes patient clinics or service providers. The electronic data collecting form was used to gather the data. RESULTS: The study revealed a stronger association between the availability of bed facilities and better glycemic control. Moreover, the majority of HCPs believes that urbanization and sedentary lifestyles are the main contributors to the rise of diabetes mellitus in Saudi Arabia. Depending on organizational features, the regulations that are available for monitoring defaulter patients and running continuous medical education (CME) programs are vastly different. The main cause of the reported lack of medications for managing diabetic care was described as being a problem with the central medical supply store's drug supply, which was influenced by the type of health sector. CONCLUSIONS: Facilitating change at all levels, including patient education, HCPs education, and organizational development, can improve the quality of treatment. The current study can provide insight into the focus of interventional strategies to deliver diabetes patients with high-quality patient care. [ABSTRACT FROM AUTHOR]

Published
2023

4. Knowledge, beliefs, and attitudes among general population towards bipolar disorders: a cross-sectional report from the Southern region of Saudi Arabia.

Author

EASWARAN, V., ALSHAHRANI, S. M., SADIQ, M. M. J., KHAN, N. A., ALAVUDEEN, S. S., ALMELEEBIA, T. M., ALKHALDI, B. A., ALSHURAYMI, M. K., ASIRI, M. Y., and KHULAIF, N. W.

Abstract

OBJECTIVE: The aim of this study was to understand the impact of demographic characteristics and to describe the gender differences in knowledge, beliefs, and attitudes towards bipolar disorders among common residents in the southern region of Saudi Arabia. SUBJECTS AND METHODS: This cross-sectional survey was conducted between January 2021 and March 2021. The survey was conducted among the common residents in the Southern region of the Kingdom of Saudi Arabia. The data were collected by using a structured, self-administered, validated questionnaire comprised of a dichotomous type of questions along with Likert scale. RESULTS: There is a significant difference in the distribution of knowledge scores between male and female study participants (p=0.000). No significant gender differences have been identified in beliefs and attitudes toward bipolar disorder (p=0.229) and in overall score (p=0.159). The traumatic event was reported as the major cause of bipolar disorder. The age group and employment status were found to be the major predictor of knowledge, beliefs, and attitudes about bipolar disorder. CONCLUSIONS: Although the knowledge awareness rate on bipolar disorder is high among public in the Southern region, there is a vast scope for improving it. Education should be disseminated to promote mental health awareness and improve attitudes and beliefs on bipolar disorders and reduce stigma and discrimination against patients with bipolar disorders. [ABSTRACT FROM AUTHOR]

Published
2023

5. Assessment of knowledge and practice of mammography and breast self-examination among the general female population in Asir region of KSA.

Author

ALQAHTANI, T., ALQAHTANI, A. M., ALSHAHRANI, S. M., ORAYJ, K., ALMANASEF, M., ALAMRI, A. H., EASWARAN, V., and KHAN, N. A.

Abstract

OBJECTIVE: Breast cancer is the most common malignancy in Kingdom of Saudi Arabia (KSA) and an increasing burden in terms of incidence, morbidity and mortality. It accounts for about 28.7% of all new cancers in women. In 2015, the Saudi cancer registry shows that breast cancer was graded first among women and it accounts for 16.7% of all cancers reported among Saudi nationals. This study was designed to assess breast cancer screening knowledge and practices among women in the Asir region, Kingdom of Saudi Arabia. MATERIALS AND METHODS: A cross-sectional study recruiting 1,021 female participants was performed. The variables included breast cancer knowledge, socio-demograph-ic features, breast self-examination knowledge and practice. Descriptive statistics was used to compare and analyze the collected data while chi-square test was used to check the statistical significance among the selected variables. Saudi married women from Asir region were the participants of this cross-sectional study. ReSULTS: Our findings suggested that participants had a satisfactory level of knowledge about breast self-examination and mammo-grams at a rate of > 90% and 44.76% respectively. Over 90% of participants had good breast self-exam knowledge, however, only 6.37% was always performed breast self-examination. Similarly, nearly 40% of participants performed mammograms, while 40.5% were unaware. Leaflets and doctors were the primary sources of information for participants regarding the information of breast cancer screening. CONCLUSIONS: Breast self-examination is a crucial approach to the timely detection of breast cancer and is subsequently critical for effective treatment. From the findings of this study we concluded that most women in the Asir region have a good awareness of breast cancer screening methods. However, either screening of self-examination or mammogram for breast cancer was not carried out thoroughly and regularly. This means that we must continue to emphasize the importance of primary health care in the earliest stages of breast cancer. [ABSTRACT FROM AUTHOR]

Published
2021

6. Experimental study on the kinetic behavior of moxifloxacin hydrochloride

Author

Baloch, N., Bhatti, W. S., Mugheri, D., Malik, E., Khan, M., Tunio, A. G., Shah, K., Bibi, H., Rehman, F. -U, Mangi, A. A., Khan, H., Kamal, T., Malhani, W. A., Shahwani, G. R., Parveen, S., YASER ALAHMADI, Aloayan, S., Alshahrani, S. M., Dar, E., Shah, S. S. A., Shahzad, M. A., Nawaz, T., Ahraf, Z., Al Thagfan, S. S., and Baloch, K.

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