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Your search keyword '"Alsalahat, Izzeddin"' showing total 27 results
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27 results on '"Alsalahat, Izzeddin"'

5. Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies

Author

Shaker, Mohamed E., primary, Goma, Hesham A. M., additional, Alsalahat, Izzeddin, additional, Elkanzi, Nadia A. A., additional, Azouz, Amany A., additional, Abdel-Bakky, Mohamed Sadek, additional, Ghoneim, Mohammed M., additional, Hazem, Sara H., additional, El-Mesery, Mohamed E., additional, Farouk, Amr, additional, Alzarea, Sami I., additional, Alsahli, Tariq G., additional, Alotaibi, Nasser Hadal, additional, Musa, Arafa, additional, Abdelgawad, Mohamed A., additional, and Bakr, Rania B., additional

Published
2023
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6. Potential covalent modification of amyloid-beta protein and its effect on aggregation

Author

Alsalahat, Izzeddin and Freeman, Sally

Subjects
616.832
Abstract

The pathogenesis of Alzheimer's disease (AD) is mainly correlated to the misfolding and aggregation of the beta-amyloid peptide. This causes extracellular amyloid-beta peptide deposition as monomers, oligomers, fibrils and plaques in the brain. Compounds that may covalently interact with amyloid-beta protein might have a role in altering the pathogenesis of AD. Some beta-lactam antibiotics (e.g. amoxicillin), orlistat, resveratrol, vanillin, o-vanillin and ethyl vanillin have been shown to modulate the process of amyloid-beta peptide aggregation using a range of techniques. Several approaches have been used to investigate modulation of amyloid-beta peptide by these compounds. These methods include molecular modelling using both covalent and non-covalent docking, investigation of covalent interaction by MALDI and LC-MS/MS mass spectrometry, and synthesis of model peptides representing key motifs in the amyloid-beta peptide, aggregation studies of amyloid-beta peptide by using the thioflavin T (ThT) fluorescence assay, studying the morphology of aggregation by atomic force microscopy (AFM), and investigating their ability to inhibit amyloid-beta peptide cell toxicity by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell toxicity assay. In non-covalent docking, amoxicillin gave the best results after curcumin when docked with amyloid-beta peptides, while in covalent docking, the binding of vanillin with Lys16 in amyloid-beta peptide was favourable. Except orlistat and resveratrol, the other compounds were found to modulate amyloid-beta peptide aggregation by covalent interaction as confirmed by mass spectrometry. Vanillin derivatives were found to interact with Lys16 in the full length amyloid-beta peptide and synthesised model peptide fragments of amyloid-beta peptide. Penicillins were also shown to covalently interact with amyloid-beta peptide, probably by interacting with a serine residue in the amyloid-beta peptide. Surprisingly, orlistat and resveratrol were shown to induce hydrolysis of amyloid-beta peptide after 10 days of incubation. All of the compounds were found to inhibit aggregation of amyloid-beta peptide as confirmed by both the ThT fluorescence assay and AFM. In addition, the compounds showed significant cytoprotective activity against amyloid-beta peptide (Aβ(1-42)) cell toxicity as shown by the MTT cell toxicity assay. The best inhibitor was orlistat, with complete cell protection, and then resveratrol. Vanillin derivatives showed similar activity, whilst the weakest inhibitor was amoxicillin.

Published
2012

8. Greenness Assessment of Chromatographic Methods Used for Analysis of Empagliflozin: A Comparative Study

Author

Santali, Eman Y., primary, Naguib, Ibrahim A., additional, Alshehri, Abdullah M., additional, Alzahrani, Yazeed A., additional, Alharthi, Abdullah E., additional, Alosaimi, Turki S., additional, Alsayali, Bandar D., additional, Alsalahat, Izzeddin, additional, Almahri, Albandary, additional, Abourehab, Mohammed A. S., additional, and Abdallah, Fatma F., additional

Published
2022
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9. Tunable Polymeric Mixed Micellar Nanoassemblies of Lutrol F127/Gelucire 44/14 for Oral Delivery of Praziquantel: A Promising Nanovector against Hymenolepis nana in Experimentally-Infected Rats

Author

Arafa, Waleed M., primary, Elkomy, Mohammed H., additional, Aboud, Heba M., additional, Ali, Mona Ibrahim, additional, Abdel Gawad, Samah S., additional, Aboelhadid, Shawky M., additional, Mahdi, Emad A., additional, Alsalahat, Izzeddin, additional, and Abdel-Tawab, Heba, additional

Published
2022
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11. Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats

Author

Elkomy, Mohammed H., primary, Eid, Hussein M., additional, Elmowafy, Mohammed, additional, Shalaby, Khaled, additional, Zafar, Ameeduzzafar, additional, Abdelgawad, Mohamed A., additional, Rateb, Mostafa E., additional, Ali, Mohammed R.A., additional, Alsalahat, Izzeddin, additional, and Abou-Taleb, Heba A., additional

Published
2022
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14. Green Assessment of Chromatographic Methods Used for the Analysis of Four Methamphetamine Combinations with Commonly Abused Drugs

Author

Alharthy, Saif A., primary, Alharthi, Muath A., additional, Almalki, Sultan A., additional, Alosaimi, Sattam H., additional, Aqeel, Abdullah H., additional, Altowairqi, Sultan A., additional, Alsalahat, Izzeddin, additional, Panda, Dibya Sundar, additional, Alsheikh, Mona Y., additional, and Naguib, Ibrahim A., additional

Published
2022
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25. Peppermint Aqueous Extract Counteracts Smooth Muscle Contraction in Rat Ileum.

Author

Abuirmeileh, Amjad, Alkhodari, Abdulrahman, Alnnjeeli, Amal, Talhouni, Ahmad, Alsalahat, Izzeddin, and Naddaf, Ahmad

Subjects
PEPPERMINT, GASTROINTESTINAL diseases, PHARMACOLOGY, LABORATORY rats, SMOOTH muscle
Abstract

Copyright of Jordan Journal of Pharmaceutical Sciences is the property of University of Jordan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2014
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26. Targeting -Aminobutyric Acid (GABA) Carriers to the Brain: Potential Relevance as Antiepileptic Pro-Drugs

Author

Semreen, Mohammad, El-Shorbagi, Abdel-Nasser, Al-Tel, Taleb, and Alsalahat, Izzeddin

Abstract

The search for antiepileptic compounds with more selective activity continues to be an area of intensive investigation in medicinal chemistry. 3,5-Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives, 3a-g, potential prodrugs incorporating the neurotransmitter GABA were synthesized and studied for crossing the blood-brain barrier (BBB). Compounds were prepared from primary amines and carbon disulfide to give dithiocarbamates 2a-g which upon reaction in situ with formaldehyde provided the intermediates Ia-g. Addition of Ia-g onto GABA furnished the title compounds 3a-g. The structures were verified by spectral data and the amounts of the compounds in the brain were investigated by using HPLC. The concentration profiles of the tested compounds in mice brain were determined and the in vivo anticonvulsant activity was measured.

Published
2010

27. Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro / in vivo evaluation.

Author

Elkomy MH, El Menshawe SF, Kharshoum RM, Abdeltwab AM, Hussein RRS, Hamad DS, Alsalahat I, and Aboud HM

Subjects
Animals, Bronchodilator Agents, Child, Humans, Lung, Particle Size, Rats, Asthma drug therapy, Terbutaline therapeutic use
Abstract

Asthma represents a globally serious non-communicable ailment with significant public health outcomes for both pediatrics and adults triggering vast morbidity and fatality in critical cases. The β 2 -adrenoceptor agonist, terbutaline sulfate (TBN), is harnessed as a bronchodilator for monitoring asthma noising symptoms. Nevertheless, the hepatic first-pass metabolism correlated with TBN oral administration mitigates its clinical performance. Likewise, the regimens of inhaled TBN dosage forms restrict its exploitation. Consequently, this work is concerned with the assimilation of TBN into a novel non-phospholipid nanovesicular paradigm termed novasomes (NVS) for direct and effective TBN pulmonary targeting. TBN-NVS were tailored based on the thin film hydration method and Box-Behnken design was applied to statistically optimize the formulation variables. Also, the aerodynamic pattern of the optimal TBN-NVS was explored via cascade impaction. Moreover, comparative pharmacokinetic studies were conducted using a rat model. TBN elicited encapsulation efficiency as high as 70%. The optimized TBN-NVS formulation disclosed an average nano-size of 223.89 nm, ζ potential of -31.17 mV and a sustained drug release up to 24 h. Additionally, it manifested snowballed in vitro lung deposition behavior in cascade impactor with a fine particle fraction of 86.44%. In vivo histopathological studies verified safety of intratracheally-administered TBN-NVS. The pharmacokinetic studies divulged 3.88-fold accentuation in TBN bioavailability from the optimum TBN-NVS versus the oral TBN solution. Concisely, the results proposed that NVS are an auspicious nanovector for TBN pulmonary delivery with integral curbing of the disease owing to target specificity.

Published
2022
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