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Inappropriate use of drugs will have a large and detrimental impact on the unit or health care institution for patients and the community. Therefore, it is necessary to select and use drugs appropriately, so that drug interventions can achieve their goals (patient healing) with minimal drug side effects. This study aims to determine the pattern of use of antihypertensive drugs in patients with hypertension in the outpatient unit of Kowel Health Center, Pamekasan Regency. Samples were taken from medical records of hypertensive patients from January to May 2022 with a total sample of 75 patients. The research variables included the type of drug, dose, frequency, duration of use, side effects, drug interactions, and patient control routines. The most widely used single dose drug was calcium antagonist, namely amlodipine in 46 patients (61.33%). And the highest combination dose was found in calcium antagonist + Ace Inhibitor, namely amlodipine and captopril in 3 patients (4%). [ABSTRACT FROM AUTHOR]