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Danah Abdullah Albarrak,1 Abdulrahman Bandar Alotaibi,2 Roaa Faisal Alotaibi,3 Sara Hussain Alramadhan,3 Alhanouf Ibrahim Bin Muhanna,1 Abdulrahman Mohammed Aldehan,2 Khalid A Bin Abdulrahman4 1College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Department of Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, 13317, Saudi Arabia; 3Department of Medicine, College of Medicine, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia; 4Department of Medical Education, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317-4233, Saudi ArabiaCorrespondence: Abdulrahman Bandar Alotaibi, Department of Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, 13317, Saudi Arabia, Email abdulrahmanbto@gmail.comBackground: High prevalence of mental disorders is associated with psychoactive substances, significantly contributing to morbidity, disability, and premature mortality. Worldwide, individuals who use electronic-cigarettes (EC) and have a mental health diagnosis are more likely to experience stress, depression, and drug use. This study aims to measure the prevalence of both EC use and mental health disorders namely, anxiety and depression additionally to investigate the association between EC use and mental health status among the general population of Saudi Arabia.Methods: A cross-sectional analytical study was conducted across Saudi Arabia from November 2022 to May 2023. The survey was divided into three sections. The first section focuses on the demographics, while the second part asked about both conventional and EC smoking and their frequency. The third section assessed mental health status using a Patient Health Questionnaire with a 9-item depression scale (PHQ-9) and a 7-item Generalized Anxiety Disorder scale (GAD-7).Results: The study revealed 21.1% reporting EC use in the past thirty days. While 19.8% reported smoking tobacco one or more days within the last thirty days. Regarding mental health, 36.6% of individuals had minimal anxiety, while 42.4% experienced mild anxiety. Moreover, most of the participant were considered to have mild followed by minimal depression accounting for 36.7% and 31.9%, respectively. The results indicated a positive and significant correlation between perceived depression scores and nicotine dependence among EC users. Additionally, there was a strong relationship between gender and nicotine dependence, with men being more inclined than women.Conclusion: There is a correlation between nicotine use and mental health outcomes; people who use nicotine products are more likely to experience anxiety and depression.Keywords: e-cigarettes, EC, mental health, anxiety, depression

Background: The World Health Organization defines health as complete physical, mental, and social well-being. Chronic diseases impact health-related quality of life (QoL). Health services for ill populations, including end-stage renal disease (ESRD), focus on QoL issues and mental health promotion. Kidney transplantation is the optimal form, but most patients require dialysis, which can be hemodialysis (HD) or peritoneal dialysis (PD). It is believed that choosing the proper modality will help in improving patient's QoL and satisfaction rate. To help patients select the mode of dialysis that best meets their needs while they have ESRD, this study intends to investigate differences in QoL between dialysis modalities., Methodology: It was a multicenter cross-sectional study conducted in Saudi Arabia, focusing on HD and PD patients in specific hospitals. Data was collected through a specially designed online questionnaire and analyzed with IBM SPSS 29 (IBM Corp. Released 2023. IBM SPSS Statistics for Windows, Version 29.0.2.0 Armonk, NY: IBM Corp)., Results: Our study, including 307 dialysis patients in Saudi Arabia, revealed a male predominance (56.0%), primarily aged 45-64 years (43.0%), with 91.5% Saudi nationals. Employment varied (27.4% professionals), and most earned 10,000-20,000 SAR monthly (50.5%). Positive life changes post-dialysis were reported by 98.7%, with 94.5% not requiring post-dialysis absence from work. Incenter HD patients constitute 45.3% while PD patients constitute 54.7% of the study sample. Physical well-being showed significant differences in nausea (p=0.035). Social and emotional well-being exhibited acceptance variations (p=0.012) and coping satisfaction (p=0.014). Linear regression indicated monthly income impact on HD QoL (B=-3.706, p=0.075), while age influenced PD QoL (B=0.113, p=0.927)., Conclusion: Our study underscores positive life changes and minimal work absence is prevalent among dialysis patients. PD exhibits higher nausea and lower family acceptance. HD participants report greater coping satisfaction. The study reveals nuanced differences in well-being dimensions, contributing insights for tailored interventions and patient-centered care in renal replacement therapies., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Almaarefa University issued approval IRB23057. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2025, Alhabib et al.)

Objective: Oral plasma cell mucositis (PCM) or localized plasma cell gingivitis (PCG) is an idiopathic inflammatory condition often associated with hypersensitivity reactions. This study aimed to evaluate the frequency and features of PCM/PCG in a large biopsy service over a time period of more than 20 years., Study Design: The biopsy archives at University of Florida College of Dentistry were searched from 2000 through the first quarter of 2023 for cases of oral PCM or PCG. Case data were aggregated and analyzed., Results: A total of 107 cases were included. Between 2000 and 2019, PCM/PCG was diagnosed in 0.03% of all biopsy cases. Starting in 2020 through 2023, the percentage of biopsies diagnosed as PCM/PCG increased threefold to 0.10% of all biopsy cases, and the mean patient age increased by 3 years. There were no statistically significant differences between cases diagnosed from 2000 to 2019 and those from 2020 to 2023 regarding age, sex, location, or histology., Conclusions: A significant increase in PCM/PCG was identified in this study at one institution coinciding with the start of the COVID-19 pandemic. Further investigation is recommended to determine if this is a widespread phenomenon and identify possible etiologic mechanisms., Competing Interests: Declaration of interest None., (Copyright © 2023 Elsevier Inc. All rights reserved.)