881 results on '"Alopecia complications"'
Search Results
2. Association of Primary Cicatricial Alopecia with Subsequent Cardiovascular Disease.
- Author
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Kim SR, Yu DA, Cho SI, and Kwon O
- Subjects
- Humans, Female, Male, Middle Aged, Cicatrix etiology, Cicatrix pathology, Cicatrix complications, Adult, Aged, Alopecia pathology, Alopecia complications, Alopecia etiology, Cardiovascular Diseases etiology
- Published
- 2024
- Full Text
- View/download PDF
3. Secondary syphilis presenting with alopecia and leukoderma in a stable HIV-positive patient in a resource-limited setting: a case report.
- Author
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Khumalo S, Mafulu Y, Williams V, Musarapasi N, Haumba S, and Dube N
- Subjects
- Adult, Female, Humans, Alopecia complications, Black People, HIV Infections complications, HIV Infections drug therapy, HIV Seropositivity complications, Hypopigmentation complications, Syphilis complications, Syphilis diagnosis, Syphilis drug therapy
- Abstract
Background: Syphilis is an infection caused by the bacteria Treponema pallidum. It is mainly transmitted through oral, vaginal and anal sex, in pregnancy and through blood transfusion. Syphilis develops in primary, secondary, latent and tertiary stages and presents with different clinical features at each stage. Infected patients can remain asymptomatic for several years and, without treatment, can, in extreme cases, manifest as damage in several organs and tissues, including the brain, nervous tissue, eyes, ear and soft tissues. In countries with a high human immunodeficiency virus (HIV) burden, syphilis increases the risk of HIV infections. We report the case of a young HIV-positive black woman who presented with alopecia and hypopigmentation as features of secondary syphilis., Case Presentation: A virologically suppressed 29-year-old woman on Anti-retroviral Therapy (ART) presented with a short history of generalized hair loss associated with a non-itchy maculopapular rash and skin depigmentation on the feet. Limited laboratory testing confirmed a diagnosis of secondary syphilis. She was treated with Benzathine Penicillin 2.4MU. After receiving three doses of the recommended treatment, the presenting features cleared, and the patient recovered fully., Conclusion: This case demonstrates the importance of a high index of clinical suspicion and testing for syphilis in patients presenting with atypical clinical features of secondary syphilis, such as hair loss and hypopigmentation. It also highlights the challenges in diagnosing and clinically managing syphilis in a resource-limited setting., (© 2024. The Author(s).)
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- 2024
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4. Skin manifestations in adults with gender dysphoria on hormone treatment in the outpatient clinic of Hospital de San José, Bogotá-Colombia.
- Author
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Castañeda MFO, Cortés HT, Isaac NG, and Cárdenas CM
- Subjects
- Male, Adult, Humans, Female, Adolescent, Young Adult, Colombia epidemiology, Cross-Sectional Studies, Quality of Life, Alopecia chemically induced, Alopecia drug therapy, Alopecia complications, Ambulatory Care Facilities, Hormones adverse effects, Gender Dysphoria drug therapy, Gender Dysphoria complications, Acne Vulgaris drug therapy, Acne Vulgaris etiology
- Abstract
Background: Comprehensive healthcare for patients with gender dysphoria includes access to gender-affirming hormone therapy. It may cause cutaneous and adnexal side effects, which often affect quality of life, are underdiagnosed, and do not receive timely treatment. The literature on this subject is scarce. The main objective was to identify skin manifestations secondary to hormone treatment in adults with gender dysphoria., Methods: Observational, descriptive, cross-sectional study. A search was performed in the database of patients with gender dysphoria older than 18 years treated at the dermatology and/or endocrinology outpatient clinic of the Hospital de San José de Bogotá in the period 2015-2021. Medical records of patients on hormone therapy with skin manifestations were selected, while patients using other medications as possible triggers were excluded., Results: In total, 85 patients were included, with a predominance of young transgender men (average age was 27 ± 9 years) in whom the main manifestation was acne (87%), followed by androgenetic alopecia and acanthosis nigricans. Transgender women presented more acne, androgenetic alopecia, hypertrichosis, seborrheic dermatitis, and melasma. The majority received treatment, mainly topical therapies. More than half of the patients were treated by the endocrinology and dermatology services., Conclusions: Skin manifestations in patients with gender dysphoria on hormone therapy are frequent, so they should be known and taken into account in the multidisciplinary approach to these patients, which should involve dermatologists. This is the first Colombian and Latin American study focused on documenting skin manifestations in patients with gender dysphoria undergoing hormone therapy., (© 2023 the International Society of Dermatology.)
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- 2024
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5. Sensitisation to ethylhexyl salicylate: Another piece of the frontal fibrosing alopecia puzzle.
- Author
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Pastor-Nieto MA, Gatica-Ortega ME, and Borrego L
- Subjects
- Humans, Female, Middle Aged, Sunscreening Agents adverse effects, Alopecia complications, Patch Tests adverse effects, Salicylates adverse effects, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Dermatitis, Allergic Contact epidemiology, Cosmetics
- Abstract
Background: There is speculation that some environmental factors may be impacting the increasing incidence of frontal fibrosing alopecia (FFA). In a recent publication, sensitisation to benzyl salicylate was shown to be prevalent among 36 patients with FFA. Ethylhexyl salicylate (EHS), a light stabiliser, ultraviolet (UV) B absorber and UV filter, frequently found in photoprotectors/cosmetics and, rarely reported as a sensitiser, was not patch tested in said research., Methods: From January 2021 to February 2022, 33 patients with FFA were patch-tested with the European Photopatch Series, including EHS 10% pet. in two hospitals. In addition, we conducted a literature review and a market survey., Results: Patch test reactions to EHS were identified in 9 of 33 (27.3%). Four of nine also reacted to their personal sunscreens (containing EHS). All involved women with a mean age of 54 (30-65). Five patients had been diagnosed with FFA before the patch tests; and, four were diagnosed with FFA during the patch test investigations., Conclusion: Sensitisation to EHS was frequently found in a selected population of patients with FFA. We propose to expand the spectrum of contact allergens described in patients with FFA to include EHS and discuss the possible need for optimization of the patch test preparation., (© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2024
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6. Comorbidities in patients with central centrifugal cicatricial alopecia: a case-control study.
- Author
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Joshi TP, Duruewuru A, Garcia D, Mireles N, Truong P, and Cockerell CJ
- Subjects
- Humans, Case-Control Studies, Scalp pathology, Comorbidity, Cicatrix complications, Cicatrix epidemiology, Alopecia complications, Alopecia epidemiology, Alopecia pathology, Dermatitis pathology
- Published
- 2024
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7. Clinical effects of autologous follicular unit extraction transplantation in the treatment of secondary cicatricial alopecia after infections.
- Author
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Niu Y, Ren C, Liao H, Jin Z, and Zhu L
- Subjects
- Humans, Alopecia surgery, Alopecia complications, Postoperative Complications etiology, Postoperative Complications surgery, Skin Transplantation methods, Transplantation, Autologous adverse effects, Retrospective Studies, Cicatrix etiology, Cicatrix surgery, Hair Follicle pathology
- Abstract
Objective: To explore the clinical effects of autologous follicular unit extraction (FUE) transplantation in the treatment of secondary scarring alopecia caused by infections, and to evaluate its effectiveness., Methods: A retrospective observational study has been conducted, which included nine patients with secondary scarring alopecia caused by infections. All patients underwent initial autologous FUE hair transplantation surgery, and the occurrence of postoperative complications was monitored. Patient satisfaction was evaluated after 12 months post-surgery., Results: At the follow-up, postoperative satisfaction was 88.9% in nine patients, with only one case of postoperative infection and no incidence of skin necrosis, significant bruising and swelling, unnatural appearance or temporary hair loss., Conclusions: Autologous FUE hair transplantation is an effective method for treating secondary scarring alopecia caused by infections. This procedure is minimally invasive, resulting in high patient satisfaction and minimal complications postoperatively., (© 2023 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
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- 2024
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8. Role of zinc in chronic telogen effluvium in serum and hair of patients with alopecia.
- Author
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Zufishan S, Haque Z, Nazar S, Afaq E, Aamir E, and Rafique S
- Subjects
- Male, Female, Humans, Young Adult, Adult, Case-Control Studies, Alopecia complications, Alopecia diagnosis, Hair, Zinc, Alopecia Areata
- Abstract
Objectives: To determine the levels of zinc in hair and serum samples of chronic telogen effluvium patients., Methods: The case-control study was conducted at the Dow University of Health Sciences, Karachi, from April 2017 to May 2018, and comprised diagnosed cases of chronic telogen effluvium in group A, and healthy controls matched for age and gender in group B. Hair pull test was done, and level of zinc in hair and serum samples was determined using atomic absorption spectrophotometer. Data was analysed using SPSS 21., Results: Of the 100 subjects, 50(50%) were in group A; 28(56%) females ad 22(44%) males with mean age 27.46±4.98 years. There were 50(50%) subejcts in group B; 26(52%) males ad 24(48%) females with mean age 28.34±4.92 years (p>0.05). Significantly low levels of zinc were observed in serum as well as hair samples in group A compared to group B (p<0.05). A positive significant association was observed in the level of zinc in hair with their concentration in the serum of subjects in both the groups (r=0.310, p<0.05)., Conclusions: Low levels of zinc in hair and serum were found to be associated with chronic telogen effluvium.
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- 2024
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9. The Gabrin sign's potential for identifying high-risk patients for COVID-19 with androgenic alopecia.
- Author
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Mohta A, Pareek S, Prasad V, Mohta A, and Nyati A
- Subjects
- Humans, Alopecia complications, Alopecia diagnosis, Scalp, COVID-19
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- 2024
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10. Male-Pattern Vertex Baldness Trajectories, Chest Hair Patterns, and Odds of Overall and Aggressive Prostate Cancer.
- Author
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Salmon C, Mesidor M, Rousseau MC, Richard H, Weiss D, Spence AR, and Parent ME
- Subjects
- Humans, Male, Adult, Case-Control Studies, Alopecia epidemiology, Alopecia complications, Prostate pathology, Hair, Prostatic Neoplasms epidemiology, Prostatic Neoplasms pathology
- Abstract
Background: The link between hormones and hair growth is well established. Inconsistent associations have been found between hair patterns and cancer of the prostate, a hormone-dependent organ. We assessed vertex baldness trajectories, chest hair amount, and their relationships with the odds of developing prostate cancer in a large case-control study in Montreal, Canada., Methods: In-person interviews were conducted with 1,931 incident prostate cancer cases and 1,994 population-based age-matched (±5 years) controls. Participants reported their hair patterns using the validated Hamilton-Norwood scale of baldness for 10-year increments starting at age 30, and their current amount of chest hair. Group-based trajectories were used to identify men sharing similar patterns of vertex baldness severity over adulthood. Multivariable logistic regression assessed associations between indicators of baldness (frontal, vertex, age at onset, severity, and trajectories), chest hair, and odds of prostate cancer., Results: Vertex balding onset at age 30 was associated with increased odds of overall prostate cancer [Odds ratio (OR), 1.30; 95% confidence interval (CI), 1.03-1.64]. Men in the trajectory characterized by early moderate vertex baldness and developing severe baldness had increased odds of overall (OR, 1.42; 95% CI, 1.03-1.96) and especially aggressive prostate cancer (OR, 1.98; 95% CI, 1.21-3.22) compared with men without baldness. Men with little chest hair had higher odds of aggressive tumors than those with a moderate amount/a lot of chest hair., Conclusions: Early-onset moderate vertex baldness that progresses and having little chest hair may be useful biomarkers of aggressive prostate cancer., Impact: Integration of early-onset vertex balding patterns into risk prediction models of aggressive prostate cancer should be envisaged., (©2023 American Association for Cancer Research.)
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- 2024
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11. Association Between LDL-C and Androgenetic Alopecia Among Female Patients in a Specialty Alopecia Clinic.
- Author
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Devjani S, Ezemma O, Jothishankar B, Kelley KJ, and Senna MM
- Subjects
- Humans, Female, Cholesterol, LDL, Alopecia diagnosis, Alopecia complications
- Published
- 2024
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12. Woodhouse-Sakati syndrome in an Indian patient with a novel pathogenic variant.
- Author
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Amalnath SD, Jothivanan, Oshima J, Buchan JG, and Paolucci S
- Subjects
- Humans, Male, Hemoptysis, Nuclear Proteins genetics, Alopecia complications, Alopecia diagnosis, Alopecia genetics, Ubiquitin-Protein Ligase Complexes, Diabetes Mellitus diagnosis, Diabetes Mellitus genetics, Diabetes Mellitus pathology, Intellectual Disability diagnosis, Intellectual Disability genetics, Intellectual Disability pathology, Hypogonadism diagnosis, Hypogonadism genetics, Hypogonadism pathology
- Abstract
Woodhouse-Sakati syndrome consists of hypogonadism, diabetes mellitus, alopecia, ECG abnormalities, and dystonia. This condition is caused by the loss of function of the DCAF17 gene. Most of the patients have been reported from Greater Middle Eastern countries. We report a 38 male from southern India who presented with syncope and massive hemoptysis due to ruptured bronchopulmonary collaterals. He also had alopecia, cataracts, recently diagnosed diabetes and hypogonadism. Whole exome sequencing showed a novel homozygous truncating variant in the DCAF17 gene. Despite embolization of the aortopulmonary collaterals, the patient died of recurrent hemoptysis., (© 2023 Wiley Periodicals LLC.)
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- 2024
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13. [Systemic lupus erythematosus associated macrophage activation syndrome with neuropsychiatric symptoms: A report of 2 cases].
- Author
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Luo ZJ, Wu JJ, Song Y, Mei CL, and DU R
- Subjects
- Humans, Female, Adult, Rituximab therapeutic use, Retrospective Studies, Methylprednisolone therapeutic use, Fever drug therapy, Erythema complications, Erythema drug therapy, Hormones therapeutic use, Alopecia complications, Alopecia drug therapy, Triglycerides therapeutic use, Ferritins therapeutic use, Macrophage Activation Syndrome diagnosis, Macrophage Activation Syndrome drug therapy, Macrophage Activation Syndrome etiology, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic drug therapy, Lupus Vasculitis, Central Nervous System, Anemia
- Abstract
Systemic lupus erythematosus (SLE) associated macrophage activation syndrome (MAS) is clinically severe, with a high mortality rate and rare neuropsychiatric symptoms. In the course of diagnosis and treatment, it is necessary to actively determine whether the neuropsychiatric symptoms in patients are caused by neuropsychiatric systemic lupus erythematosus (NPSLE) or macrophage activation syndrome. This paper retrospectively analyzed the clinical data of 2 cases of SLE associated MAS with neuropsychiatric lesions, Case 1: A 30-year-old female had obvious alopecia in 2019, accompanied by emaciation, fatigue and dry mouth. In March 2021, she felt weak legs and fell down, followed by fever and chills without obvious causes. After completing relevant examinations, she was diagnosed with SLE and given symptomatic treatments such as hormones and anti-infection, but the patient still had fever. The relevant examinations showed moderate anemia, elevated ferritin, elevated triglycerides, decreased NK cell activity, and a perforin positivity rate of 4.27%, which led to the diagnosis of "pre-hemophagocytic syndrome (HPS)". In May 2021, the patient showed mental trance and babble, and was diagnosed with "SLE-associated MAS"after completing relevant examinations. After treatment with methylprednisolone, anti-infection and psychotropic drugs, the patient's temperature was normal and mental symptoms improved. Case 2: A 30-year-old female patient developed butterfly erythema on both sides of the nose on her face and several erythema on her neck in June 2019, accompanied by alopecia, oral ulcers, and fever. She was diagnosed with "SLE" after completing relevant examinations, and her condition was relieved after treatment with methylprednisolone and human immunoglobulin. In October 2019, the patient showed apathy, no lethargy, and fever again, accompanied by dizziness and vomiting. The relevant examination indicated moderate anemia, decreased NK cell activity, elevated triglycerides, and elevated ferritin. The patient was considered to be diagnosed with "SLE, NPSLE, and SLE-associated MAS". After treatment with hormones, human immunoglobulin, anti-infection, rituximab (Mabthera), the patient's condition improved and was discharged from the hospital. After discharge, the patient regularly took methylprednisolone tablets (Medrol), and her psychiatric symptoms were still intermittent. In November 2019, she developed symptoms of fever, mania, and delirium, and later turned to an apathetic state, and was given methylprednisolone intravenous drip and olanzapine tablets (Zyprexa) orally. After the mental symptoms improved, she was treated with rituximab (Mabthera). Later, due to repeated infections, she was replaced with Belizumab (Benlysta), and she was recovered from her psychiatric anomalies in March 2021. Through the analysis of clinical symptoms, imaging examination, laboratory examination, treatment course and effect, it is speculated that the neuropsychiatric symptoms of case 1 are more likely to be caused by MAS, and that of case 2 is more likely to be caused by SLE. At present, there is no direct laboratory basis for the identification of the two neuropsychiatric symptoms. The etiology of neuropsychiatric symptoms can be determined by clinical manifestations, imaging manifestations, cerebrospinal fluid detection, and the patient's response to treatment. Early diagnosis is of great significance for guiding clinical treatment, monitoring the condition and judging the prognosis. The good prognosis of the two cases in this paper is closely related to the early diagnosis, treatment and intervention of the disease.
- Published
- 2023
14. Response to "Lack of association between comorbidities and central centrifugal cicatricial alopecia: a retrospective cohort study of 153 patients".
- Author
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Leung BW, Glass DA 2nd, and Ayoade K
- Subjects
- Humans, Retrospective Studies, Scalp, Alopecia complications, Alopecia epidemiology, Dermatitis
- Abstract
Competing Interests: Conflicts of interest None disclosed.
- Published
- 2023
- Full Text
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15. Non-scarring alopecia of lupus erythematosus: A comprehensive review.
- Author
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Perales A, Lipsker D, Cribier B, and Lenormand C
- Subjects
- Humans, Cicatrix etiology, Cicatrix pathology, Alopecia complications, Panniculitis, Lupus Erythematosus complications, Skin Diseases complications, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Cutaneous pathology
- Abstract
Background: Although non-scarring alopecia (NSA) is a frequent clinical finding in patients with systemic lupus erythematosus (SLE), it has been poorly described in the literature. It is considered a nonspecific sign in the current classification of skin lesions of LE. The aim of this study was to give an updated overview of the spectrum of NSA in LE patients, with emphasis on the clinical significance thereof., Method: We conducted a review of the English literature using the PubMed-Medline database using the keywords "Alopecia" + "Lupus erythematosus". Publications describing LE patients with NSA were included., Results: Data for 237 patients from 27 publications were analyzed. Ninety-one patients had diffuse NSA, 43 had patchy NSA, 83 had lupus hair, 3 had alopecia of dermal cutaneous LE, and 17 had alopecia of linear and annular lupus panniculitis of the scalp. Patients with diffuse/patchy NSA and lupus hair shared the following features: strong association with systemic activity of LE, subtle clinical/trichoscopic signs of inflammation, histological aspect consistent with lesions specific to cutaneous LE, high likelihood of response to SLE therapy, and absence of progression to scarring alopecia. Association with SLE was rare in patients with dermal cutaneous LE or linear and annular lupus panniculitis of the scalp, and skin-directed therapies were most often effective. One patient of each subtype progressed to scarring alopecia., Discussion: Diffuse/patchy NSA and lupus hair may represent a topographic variation of a single entity specific for LE. Prospective studies are warranted to further document the clinical significance of this manifestation., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
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- 2023
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16. Patients with autosomal recessive congenital ichthyosis present a distinctive pattern of alopecia.
- Author
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Challamel C, Hernandez-Martin A, Tchitchiama C, Jonca N, Rossel SVJ, Gostyński A, and Mazereeuw-Hautier J
- Subjects
- Humans, Alopecia complications, Alopecia genetics, Genes, Recessive, Ichthyosis, Lamellar genetics
- Published
- 2023
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17. Frontal fibrosing alopecia coexisting with vitiligo: is there a true association?
- Author
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Damke JP, Schoenardie BO, Figini Maciel R, and Peruzzo J
- Subjects
- Humans, Alopecia complications, Fibrosis, Vitiligo complications, Lichen Planus complications, Hypopigmentation
- Published
- 2023
- Full Text
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18. Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector.
- Author
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Kise S, Iijima A, Nagao C, Okada T, Nishikawa M, Ikushiro S, Nakanishi T, Sato S, Yasuda K, and Sakaki T
- Subjects
- Female, Rats, Animals, Receptors, Calcitriol genetics, Receptors, Calcitriol metabolism, Alopecia genetics, Alopecia therapy, Alopecia complications, Genetic Therapy, Adenoviridae genetics, Adenoviridae metabolism, Vitamin D therapeutic use, Rickets, Bone Diseases, Developmental
- Abstract
Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is no suitable treatment for alopecia. In this study, we verified whether gene therapy using an adenoviral vector (AdV) had a therapeutic effect on alopecia in Vdr-KO rats. The VDR-expressing AdV was injected into six 7-week-old female Vdr-KO rats (VDR-AdV rats). On the other hand, control-AdV was injected into 7-week-old female rats (control-AdV rats); non-infected Vdr-KO rats (control rats) were also examined. The hair on the backs of the rats was shaved with hair clippers, and VDR-AdV or control-AdV was intradermally injected. Part of the back skin was collected from each rat after AdV administration. Hair follicles were observed using hematoxylin and eosin staining, and VDR expression was examined using immunostaining and western blotting. VDR-AdV rats showed significant VDR expression in the skin, enhanced hair growth, and low cyst formation, whereas control-AdV and non-infected rats did not show any of these effects. The effect of VDR-AdV lasted for nearly 60 days. These results indicate that gene therapy using VDR-AdV may be useful to treat alopecia associated with type II rickets, if multiple injections are possible after a sufficient period of time., (© 2023. The Author(s).)
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- 2023
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19. A Recurrent Nonsense Mutation in NECTIN4 Underlying Ectodermal Dysplasia-Syndactyly Syndrome with a Novel Phenotype in a Consanguineous Kashmiri Family.
- Author
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Ali G, Sadia S, Ain-Ul-Batool S, Azeem Z, Awan NB, Kazmi SAR, Ur-Rehman Z, Anjum Z, Ur-Rehman F, Wali A, Khan K, Zaman N, Ayub M, Sajid M, and Hassan N
- Subjects
- Humans, Alopecia complications, Cell Adhesion Molecules genetics, Codon, Nonsense genetics, Consanguinity, Mutation, Pedigree, Phenotype, Syndrome, Cleft Lip genetics, Cleft Lip complications, Ectodermal Dysplasia genetics, Ectodermal Dysplasia complications, Jaw Abnormalities complications, Nectins genetics, Syndactyly genetics, Syndactyly complications
- Abstract
EDSS1, a syndrome characterized by ectodermal dysplasia-syndactyly, is inherited in an autosomal recessive manner due to mutations in the NECTIN4/PVRL4 gene. Clinical manifestations of the syndrome include defective nail plate, sparse to absent scalp and body hair, spaced teeth with enamel hypoplasia, and bilateral cutaneous syndactyly in the fingers and toes. Here, we report a consanguineous family of Kashmiri origin presenting features of EDSS1. Using whole exome sequencing, we found a recurrent nonsense mutation (NM_030916: c.181C > T, p.(Gln61 ∗ )) in the NECTIN4 gene. The variant segregated perfectly with the disorder within the family. The candidate variant was absent in 50 in-house exomes pertaining to other disorders from the same population. In addition to the previously reported clinical phenotype, an upper lip cleft was found in one of the affected members as a novel phenotype that is not reported by previous studies in EDSS1 patients. Therefore, the study presented here, which was conducted on the Kashmiri population, is the first to document a NECTIN4 mutation associated with the upper lip cleft as a novel phenotype. This finding broadens the molecular and phenotypic spectrum of EDSS1., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Ghazanfar Ali et al.)
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- 2023
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20. Association between androgenetic alopecia and periodontitis.
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Karasu YÖ, Orbak R, Kaşalı K, Berker E, and Kantarci A
- Subjects
- Male, Humans, Nutrition Surveys, Alopecia complications, Testosterone, Periodontitis complications, Periodontal Diseases complications
- Abstract
Aim: Androgenic alopecia (AGA) is men's most common form of hair loss. It is affected by changes in the expression and activity of 5αR and the metabolism of testosterone and DHT. There is an association between AGA and systemic inflammatory diseases. We hypothesized that there is an association between AGA and periodontal disease, as inflamed gingiva and periodontal fibroblasts have been shown to express more 5αR. Thus, this study aimed to evaluate the relationship between periodontal disease and AGA and the potential effect of aging on this association., Materials and Methods: Out of a cohort of 1088 individuals, 385 white males aged 25-65 with similar socioeconomic levels and without systemic disease were included. Periodontitis was defined using NHANES data. AGA was evaluated using the Norwood-Hamilton scale. The relationship between AGA, periodontal disease severity, and age was assessed., Results: There was a correlation between age and baldness (r = .421, p < .001). There was a significant correlation between AGA and periodontal disease in younger patients aged 25-34 and 35-44. (p < .042 and p < .036, respectively). There was no significant correlation between AGA and periodontal disease in the 45-54 and 55-65 age groups (p > .05)., Conclusion: There may be a relationship between periodontal disease and AGA in the 25-44 age range, suggesting that this association starts at an early age in adulthood., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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- 2023
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21. [Review of the post-COVID-19 syndrome associated to acute telogen effluvium].
- Author
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Chávez-Chavira G
- Subjects
- Humans, Post-Acute COVID-19 Syndrome, Quality of Life, SARS-CoV-2, Alopecia etiology, Alopecia complications, Acute Disease, COVID-19 complications, Alopecia Areata etiology
- Abstract
Coronavirus disease 2019 (COVID-19) has impacted our society in numerous ways. So far (November 2022) around 640 million SARS-CoV-2 infections have been confirmed worldwide. It is known that this disease has a main affection at the cardiopulmonary level, however, it affects almost all the organs and systems of the body, including the skin. Post-COVID-19 syndrome occurs in some patients, leaving significant sequelae that impact their quality of life. Among the most common sequelae are: cough, dyspnea, chronic fatigue, hyposmia and dysosmia. In addition to these, other sequelae not related to respiratory syndrome have been reported, such as hair loss, which has been observed in around 20% of post-COVID-19 patients, this could be attributable to acute telogen effluvium (TE). To date, no study has been conducted to determine the relationship of ET in those who have had COVID-19. Acute ET is defined as diffuse, non-scarring hair loss, usually self-limited, lasting for about 6 months. Within its etiology, severe systemic febrile illness, pregnancy, restrictive diets, severe stress and various drugs have been described. It seriously affects the quality of life of patients and is often associated with loss of confidence and low self-esteem., (Licencia CC 4.0 (BY-NC-ND) © 2023 Revista Médica del Instituto Mexicano del Seguro Social.)
- Published
- 2023
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22. Clinical and metabolic characteristics of males with early-onset androgenetic alopecia.
- Author
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Vinay K, Bhattachajee R, Bishnoi A, Kaushik A, Sachdeva N, Pal A, Narang T, and Dogra S
- Subjects
- Male, Humans, Cross-Sectional Studies, Alopecia diagnosis, Alopecia epidemiology, Alopecia complications, Metabolic Syndrome diagnosis, Metabolic Syndrome epidemiology, Metabolic Syndrome complications, Insulin Resistance, Insulins
- Abstract
Background Men with early-onset androgenetic alopecia (AGA) often have an abnormal hormonal milieu. Objective To ascertain the clinico-phenotypic characteristics and the prevalence of hormonal and metabolic changes in men with early-onset AGA. Methods Consecutive male patients less than 30 years of age with a Norwood-Hamilton grade ≥3 AGA were recruited in this comparative cross-sectional study. After endocrine evaluation they were classified into two groups, that is, Group A consisting of subjects with an altered hormonal profile and Group B with normal hormonal profiles. The groups were assessed for differences in disease phenotype and severity (Norwood-Hamilton grade), insulin resistance and parameters of metabolic syndrome (ATP III guidelines). Results Altered hormonal profiles were seen in 34 of the 100 subjects with AGA, while insulin resistance and metabolic syndrome were noted in 44 and 26 respectively. Altered hormonal profiles were significantly associated with insulin resistance and severe alopecia (grade 4 and above Hamilton-Norwood Scale). Insulin resistant Group A patients had a significantly higher prevalence of severe alopecia (>grade 4) (P = 0.0036). The prevalence of metabolic syndrome was similar in both groups. Limitation The cross sectional study design was a drawback of this study. Further, a control arm without AGA was not included and the sample size of 100 was selected arbitrarily. Conclusion An altered hormonal profile and insulin resistance was noted in a third of the males with early-onset AGA. Subjects with altered hormonal profiles had a higher prevalence of insulin resistance and were likely to have severe grades of AGA.
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- 2023
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23. Traction alopecia secondary to obsessive-compulsive disorder.
- Author
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Dogru H
- Subjects
- Humans, Alopecia complications, Alopecia diagnosis, Traction, Obsessive-Compulsive Disorder complications, Obsessive-Compulsive Disorder diagnosis
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- 2023
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24. When Recurrent Strokes, Back Pain, and Alopecia Constitute a Hereditary Cause of Small-Vessel Disease, CARASIL in an Arabic Woman.
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Al Nidawi F, Wael M, Alkhater N, Asil T, and Fida M
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- Female, Humans, Adult, Cerebral Infarction, Alopecia complications, Alopecia genetics, Back Pain, Ischemic Stroke, Cerebrovascular Disorders, Cerebral Arterial Diseases
- Abstract
Introduction: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare autosomal recessive etiology of cerebral small-vessel disease. The bulk of CARASIL cases reported in the literature was from Japan and China. Herein, we report the first genetically confirmed case of CARASIL in the Arabic population., Case Presentation: We present the case of a 35-year-old Bahraini woman diagnosed with an acute ischemic stroke after experiencing right-sided weakness and slurred speech. She had complained of persistent headaches, decreased memory, hair loss, joint pain, and personality changes. CARASIL was suspected on her medical history and brain imaging results, and genetic testing confirmed the diagnosis., Conclusion: This case contributes to our understanding of CARASIL, which is an extremely rare disease. It adds to the growing data on disease reporting outside China and Japan. We also report the first case of CARASIL in an Arabic patient and describe magnetic resonance spectroscopy finding partially different from what has been reported before., Competing Interests: The authors declare no conflict of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2023
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25. Basaloid follicular hamartoma syndrome: acquired sporadic variant with hypothyroidism, hypohidrosis and alopecia, a rare case.
- Author
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Ashraf U, Ahmed N, Jamal N, and Ahmed R
- Subjects
- Female, Humans, Middle Aged, Alopecia complications, Hypohidrosis complications, Skin Diseases, Hamartoma complications, Hamartoma diagnosis, Hypothyroidism diagnosis, Hypothyroidism complications, Skin Neoplasms complications
- Abstract
Basaloid follicular hamartoma is a rare benign malformation of hair follicles, characterised clinically as generalised or localised multiple brown papules mostly on face, scalp and trunk. It may be congenital or acquired with or without any associated disease. Histologically it is composed of epithelial proliferation of basaloid cells with radial disposition enclosed in a fibrous stroma. It is of important consideration because it can be mistaken for basal cell carcinoma both clinically and histologically. Here we report the case of a 51-year-old female with acquired, generalised basaloid follicular hamartomas associated with alopecia, hypothyroidism and hypohidrosis which is an extremely rare disease.
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- 2023
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26. Recalcitrant Cutaneous Lupus Erythematosus during COVID-19 Pandemic: A Case Report.
- Author
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Yunus M, Dahliana AP, Habar W, Ilyas F, and Wijaya JK
- Subjects
- Female, Humans, Adult, Pandemics, Alopecia complications, COVID-19 complications, Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Systemic complications
- Abstract
A 30-year-old woman visited the dermatology and venereology clinic with red rashes on her cheeks with spreading wounds to the ears present for 6 months. Similar ailments were also found on the chest and upper arms accompanying black spots on both palms. Initially, red rashes appeared intermittently, observed around the eyes and cheeks, especially at sun exposure. Tenderness or pruritus was not present; however, the patient had joints ache, sore fingers, hair loss as well as frequent fever.
- Published
- 2023
27. Novel blended SNRPE-related spliceosomopathy phenotype characterized by microcephaly and congenital atrichia.
- Author
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Amudhavalli SM, Paolillo V, Lawson C, Patterson M, Kussmann J, Nopper AJ, Lypka M, and Saunders C
- Subjects
- Humans, Phenotype, Alopecia complications, snRNP Core Proteins genetics, Microcephaly diagnosis, Microcephaly genetics, Microcephaly complications, Hypotrichosis genetics, Abnormalities, Multiple diagnosis, Abnormalities, Multiple genetics
- Abstract
Variants in genes encoding core components of the spliceosomes are associated with craniofacial syndromes, collectively called craniofacial spliceosomopathies. SNRPE encodes a core component of pre-mRNA processing U-rich small nuclear ribonuclear proteins (UsnRNPs). Heterozygous variants in SNRPE have been reported in six families with isolated hypotrichosis simplex in addition to one case of isolated non syndromic congenital microcephaly. Here, we report a patient with a novel blended phenotype of microcephaly and congenital atrichia with multiple congenital anomalies due to a de novo intronic SNRPE deletion, c.82-28_82-16del, which results in exon skipping. As discussed within, this phenotype, which we propose be named SNRPE-related syndromic microcephaly and hypotrichosis, overlaps other craniofacial splicesosomopathies., (© 2023 Wiley Periodicals LLC.)
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- 2023
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28. Genotypic Spectrum and its Correlation with Alopecia and Clinical Response in Hereditary Vitamin D Resistant Rickets: Our Experience and Systematic Review.
- Author
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Dodamani MH, Lila AR, Memon SS, Sarathi V, Arya S, Rane A, Sehemby MK, Garg R, Bhandare VV, Karlekar M, Patil VA, Kunwar A, and Bandgar TR
- Subjects
- Humans, Infant, Receptors, Calcitriol genetics, Calcium, Ligands, Retrospective Studies, Alopecia genetics, Alopecia complications, Alopecia drug therapy, Mutation, Vitamin D therapeutic use, Familial Hypophosphatemic Rickets drug therapy, Familial Hypophosphatemic Rickets genetics, Familial Hypophosphatemic Rickets complications
- Abstract
Alopecia in hereditary vitamin D resistant rickets (HVDRR) has some correlation with severe rickets and poor overall response. However, these observations are based on small series. Hence, we aim to assess the genotypic spectrum of HVDRR and its correlation with alopecia and clinical response. Seven genetically-proven HVDDR patients from five unrelated families and 119 probands from systematic review were analysed retrospectively for phenotypic and genotypic data and overall response to therapy. In our cohort mean age at rickets onset was 12 (± 3.4) months. Alopecia was present in all patients but one. All patients had poor overall response to oral high-dose calcium and calcitriol and most required intravenous calcium. Genetic analyses revealed four novel variants. On systematic review, alopecia was present in majority (81.5%) and preceded the onset of rickets. Patients with alopecia had higher serum calcium (7.6 vs.6.9 mg/dl, p = 0.008), lower 1, 25(OH)
2 D (200 vs.320 pg/ml, p = 0.03) and similar overall response to oral therapy (28.7% vs. 35.3%, p = 0.56). Alopecia was present in 51.4% of non-truncating (NT) ligand-binding domain (LBD) variants, whereas it was universal in truncating LBD and all DNA binding-domain (DBD) variants. Overall response to oral therapy was highest in LBD-NT (46.4%) as compared to 7.6% in LBD-truncating and 19% in DBD-NT variants. Among LBD-NT variants, those affecting RXR heterodimerization, but not those affecting ligand affinity, were associated with alopecia. Both alopecia and overall response have genotypic correlation. Age at diagnosis and overall response to oral therapy were similar between patients with and without alopecia in genetically proven HVDRR., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2023
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29. Androgenetic alopecia: Traditional cardiovascular risk factors, metabolic syndrome, and component traits among Nigerian adults.
- Author
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Oiwoh SO, Akinboro AO, Olayemi O, Salawu AA, Olasode OA, and Onayemi EO
- Subjects
- Humans, Adult, Male, Female, Risk Factors, Obesity, Abdominal complications, Obesity, Abdominal epidemiology, Cross-Sectional Studies, Obesity complications, Heart Disease Risk Factors, Alopecia complications, Alopecia diagnosis, Metabolic Syndrome epidemiology, Metabolic Syndrome complications, Cardiovascular Diseases epidemiology, Cardiovascular Diseases complications, Dyslipidemias epidemiology, Dyslipidemias complications
- Abstract
Background: Androgenetic alopecia (AGA) has been linked to cardiovascular diseases (CVDs) and metabolic syndrome (MetS). Works on AGA, cardiovascular risk factors (CVRFs) and MetS are rare among Nigerians., Aim: This study set out to determine the relationship among CVRFs, MetS, and AGA., Subjects and Methods: This is a cross-sectional study done among adults who were 18 years and above in selected communities in Ogbomoso on 260 consenting AGA participants as well as 260 age controls without AGA. They were matched for age and sex using a multistage sampling method. Anthropometric measurements, fasting blood glucose, and lipid profile samples were collected. MetS was diagnosed using International Diabetes Federation criteria. Data were analyzed using IBM SPSS version 20. Ethical approval was gotten before commencement of the study (LTH/OGB/EC/2017/162)., Result: Metabolic syndrome in AGA was higher than in controls (8.08% vs. 7.69%, p = 0.742). AGA was significantly associated with elevated mean systolic blood pressure (SBP) (p = 0.008), low High Density Lipoprotein (HDL-c) (p < 0.001), alcohol intake (p < 0.001), dyslipidaemia (p = 0.002), and sedentary lifestyle (p = 0.010). The correlates of AGA severity in male and female gender are age (p < 0.001 and 0.009 respectively), SBP (p = 0.024) and abdominal obesity (p = 0.027) in male gender., Conclusion: AGA in Nigerians is associated with dyslipidaemia, alcohol intake, and sedentary lifestyle. AGA severity is related to age, higher mean SBP, abdominal obesity and low HDL-c in male and age, and Body mass index in females. Nigerians with AGA should be screened for dyslipidaemia and counseled against the use of alcohol and sedentary lifestyle., Competing Interests: None
- Published
- 2023
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30. Case Report: Scarring Alopecia After Scalp Avulsion.
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Lorei NC, Sullivan JF, Lennon RP, Milder EA, and Roman JW
- Subjects
- Humans, Cicatrix complications, Risk Factors, Alopecia complications, Alopecia pathology, Scalp injuries, Scalp pathology, Amputation, Traumatic complications
- Abstract
Scalp avulsion is a rare trauma in the developed world but is a common injury in countries with poorly established infrastructure and safety regulations. This case reports the long-term sequelae of this injury, observed while conducting a humanitarian mission, and discusses immediate actions for management in an acute setting. We aim to increase awareness about this injury, its risk factors, and treatment options to better prepare clinicians in the developed world to provide care for this condition in the austere environment, which may include not only chronic pain, functional, and aesthetic concerns, but also a psychological impact that persists years after the initial injury., (Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
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- 2023
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31. Impending central retinal vein occlusion and granulomatous uveitis in a patient with Satoyoshi syndrome.
- Author
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Saima Y, Tanaka Y, Kakehashi A, and Kaburaki T
- Subjects
- Humans, Female, Child, Adult, Alopecia complications, Spasm, Retinal Vein Occlusion complications, Retinal Vein Occlusion diagnosis, Retinal Vein Occlusion drug therapy, Uveitis complications, Uveitis diagnosis, Uveitis drug therapy
- Abstract
Rationale: Satoyoshi syndrome is a rare systemic autoimmune disease that presents with painful muscle spasms. We report a case of impending central retinal vein occlusion (CRVO) secondary to granulomatous pan-uveitis in a 32-year-old woman with Satoyoshi syndrome., Patient Concerns: At the age of 7 years, she developed generalized hair loss and painful spasms and was diagnosed with Satoyoshi syndrome. Her current symptoms included sudden metamorphopsia and decreased visual acuity in the left eye. She visited our hospital with extensive intraretinal hemorrhage (including the macula), meandering of the retinal veins, and swelling of the optic disc. Fluorescence fundus angiography demonstrated hyper fluorescence of the optic disc and leakage from the retinal veins, suggesting CRVO associated with optic papillitis and segmental periphlebitis., Diagnoses: In the left eye, there were 2 + cells in the anterior chamber and 1 + in the anterior vitreous., Interventions: We increased the existing dose of prednisolone for the treatment of uveitis and started her on oral aspirin and kallidinogenase for CRVO., Outcomes: The impending CRVO gradually subsided, and her visual acuity improved. However, during the subsequent treatment course, angle nodules were observed in the left eye, and the intraocular pressure (IOP) gradually increased. Although the angled nodules disappeared with topical corticosteroid treatment, the IOP did not reduce and became uncontrolled. Therefore, we performed trabeculotomy first, followed by trabeculectomy, after which the IOP decreased to approximately 10 mm Hg., Lessons: Unilateral granulomatous pan-uveitis and impending CRVO were observed in this patient. Several cases of Satoyoshi syndrome complicated by various autoimmune or immunological disorders have been reported. However, to the best of our knowledge, no reports of Satoyoshi syndrome presenting with uveitis or CRVO have been published. Physicians should consider uveitis as a complication of Satoyoshi syndrome., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2023
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32. Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.
- Author
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Krysiak R, Basiak M, Szkróbka W, and Okopień B
- Subjects
- Male, Humans, Bromocriptine adverse effects, Prolactin, C-Reactive Protein analysis, Uric Acid, Risk Factors, Testosterone, Cholesterol, HDL, Fibrinogen analysis, Triglycerides, Alopecia drug therapy, Alopecia complications, Insulin Resistance, Cardiovascular Diseases drug therapy
- Abstract
Both hyperprolactinemia and early-onset androgenic alopecia are associated with increased cardiometabolic risk. The aim of this study was to assess whether early-onset male-pattern baldness modifies cardiometabolic effects of bromocriptine in men with prolactin excess. The study included 2 groups of men with prolactin excess: individuals with early-onset androgenic alopecia (group 1) and individuals with normal hair growth (group 2). Both groups were matched for age, smoking habits, body mass index, blood pressure, and prolactin levels. Over the entire study period (4 months), all participants were treated with bromocriptine (7.5 mg daily). Plasma levels of hormones (prolactin, total testosterone, and bioavailable testosterone), glucose homeostasis markers, lipids, uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and the urinary albumin-to-creatinine ratio (UACR) were measured at the beginning and at the end of the study period. The two groups differed in total testosterone, bioavailable testosterone, insulin sensitivity, high-density lipoprotein (HDL) cholesterol, triglycerides, uric acid, hsCRP, fibrinogen, homocysteine, and UACR. In both groups, bromocriptine reduced prolactin, increased total and bioavailable testosterone, improved insulin sensitivity, and decreased uric acid, hsCRP, and homocysteine. The impact on prolactin, insulin sensitivity, uric acid, hsCRP, and homocysteine was stronger in group 2 than in group 1. Only in group 2 did the drug increase HDL cholesterol and decrease triglycerides, fibrinogen, and UACR. The impact on cardiometabolic risk factors correlated with a reduction in prolactin levels and an improvement in insulin sensitivity, and, in group 1, inversely correlated with testosterone levels. The obtained results suggest that men with early-onset androgenic alopecia are partially resistant to the cardiometabolic effects of bromocriptine., (© 2022, The American College of Clinical Pharmacology.)
- Published
- 2023
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33. Cronkhite-Canada Syndrome- The first case from Pakistan: a case report.
- Author
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Ramzi HT, Zainab Y, Manzoor S, and Malik A
- Subjects
- Male, Humans, Middle Aged, Pakistan, Alopecia complications, Abdominal Pain etiology, Weight Loss, Peripheral Nervous System Diseases, Intestinal Polyposis complications, Intestinal Polyposis diagnosis, Intestinal Polyposis drug therapy, Hyperpigmentation etiology, Hyperpigmentation complications
- Abstract
Chronkhite-Canada Syndrome is characterised by diffuse gastrointestinal polyposis, dystrophic changes of the fingernails, cutaneous hyperpigmentation, alopecia, diarrhoea, weight loss, and abdominal pain. This disease is also associated with peripheral neuropathies and autoimmune disorders. Its association with other diseases may cause the polyps to turn into malignant tumours and worsen the condition. The first-line treatment is a combination of prednisone and mesalamine. NSAIDs and antibiotic administration is based on the symptoms and needs of patients. Here, we describe a 51-year-old male who presented to us with abdominal pain and significant weight loss. His physical examination showed dystrophic nails, alopecia and hyperpigmentation. Endoscopy and colonoscopy showed multiple polyps. His manifestations were consistent with Cronkhite-Canada syndrome. We prescribed oral corticosteroids, which improved his condition.
- Published
- 2023
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34. Comprehensive treatment of Cronkhite-Canada syndrome: A case report and literature review.
- Author
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Hu H, Wu Y, Zhang Y, Zhang L, Zhang J, and Zhang R
- Subjects
- Humans, Alopecia therapy, Alopecia complications, Intestinal Polyposis complications, Intestinal Polyposis diagnosis, Hyperpigmentation etiology, Hyperpigmentation therapy, Nail Diseases diagnosis, Nail Diseases etiology
- Abstract
Introduction: Cronkhite-Canada syndrome (CCS) is currently considered to be a non-hereditary disease, which is relatively rare clinically. It is also known as polyposis hyperpigmentation alopecia nail dystrophy syndrome, it is a syndrome characterized by gastrointestinal polyposis and ectodermal changes, the main manifestations are gastrointestinal symptoms, skin pigmentation, alopecia, and hypothyroidism., Case Presentation: In this paper, the clinical characteristics, diagnosis and treatment of a case of CCS admitted to Huanghe Sanmenxia Hospital were analyzed. In the course of treatment, traditional Chinese medicine was used, but no hormone, and the patient's clinical symptoms were greatly relieved., Conclusions: CCS is rare, there is no specific treatment, and traditional Chinese medicine may can greatly relieve the clinical symptoms of patients. However, it's still having to be verified by a large sample, multi-center, long-term treatment follow-up studies., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2023
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35. Comorbidities in patients with central centrifugal cicatricial alopecia: A retrospective chart review of 53 patients.
- Author
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Leung B, Lindley L, Reisch J, Glass DA 2nd, and Ayoade K
- Subjects
- Humans, Retrospective Studies, Comorbidity, Cicatrix epidemiology, Cicatrix etiology, Alopecia complications, Alopecia epidemiology, Dermatitis
- Abstract
Competing Interests: Conflicts of interest None disclosed.
- Published
- 2023
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36. Lack of association between comorbidities and central centrifugal cicatricial alopecia: A retrospective cohort study of 153 patients.
- Author
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Jafari AJ, Brown C, Echuri H, and Murina AT
- Subjects
- Humans, Retrospective Studies, Cicatrix epidemiology, Cicatrix etiology, Cicatrix pathology, Alopecia complications, Alopecia epidemiology, Dermatitis
- Abstract
Competing Interests: Conflicts of interest Drs Jafari, Brown, and Echuri have no conflicts of interest. Dr Andrea Murina is a speaker for Abbvie, Amgen, Bristol-Meyers-Squibb, Eli Lilly and Company, Janssen, and Ortho-Dermatologics. She has served as a consultant for Bristol-Meyers-Squibb, Janssen, Novartis, Ortho-Dermatologics, and UCB.
- Published
- 2023
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37. The psychological consequences of androgenetic alopecia: A systematic review.
- Author
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Aukerman EL and Jafferany M
- Subjects
- Male, Female, Humans, Hair, Self Concept, Anxiety etiology, Anxiety psychology, Quality of Life psychology, Alopecia complications
- Abstract
Introduction: Androgenetic alopecia is the most common cause of hair loss in both males and females. In a society that places significant value on hair and associates it with attractiveness, a lack there of can have damaging psychological consequences. The psychosocial impact of hair loss is often overlooked due to the medically benign nature of offending conditions. Addressing the psychological aspects of androgenetic alopecia can improve holistic patient care and patient outcomes., Methods: A search was conducted in PubMed using the following search strategy: androgenetic alopecia AND anxiety OR depression OR psychological OR psychosocial OR self-esteem. Studies were excluded if they focused on any other type of alopecia or were published in a language other than English., Results: A total of 13 studies were retained after the initial search process. The included studies date from 1992 to 2021. They all conclude that androgenetic alopecia serves as a significant psychosocial stressor in the lives of those affected. It impairs quality of life according to multiple measures., Conclusion: The data examined from these studies shed light on the increased need to attend to the psychosocial comorbidity associated with androgenetic alopecia. These hair-loss patients often present to dermatology clinics to seek treatment but would also benefit from psychological support., (© 2022 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
- Published
- 2023
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38. A cross-sectional, multicenter survey of the prevalence and risk factors for Long COVID.
- Author
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Imoto W, Yamada K, Kawai R, Imai T, Kawamoto K, Uji M, Kanda H, Takada M, Ohno Y, Ohtani H, Kono M, Hikiishi A, Eguchi Y, Namikawa H, Kawaguchi T, and Kakeya H
- Subjects
- Humans, Cross-Sectional Studies, Post-Acute COVID-19 Syndrome, Quality of Life, Anosmia, Dysgeusia, Prevalence, Risk Factors, Chest Pain, Dyspnea epidemiology, Fatigue epidemiology, Fatigue complications, Alopecia complications, COVID-19 epidemiology, COVID-19 complications, Sleep Initiation and Maintenance Disorders complications
- Abstract
Long-term sequelae of the coronavirus disease (COVID-19) constitute Long COVID. Although Long COVID has been reported globally, its risk factors and effects on quality of life (QOL) remain unclear. We conducted a cross-sectional study using questionnaires and electronic medical records of COVID-19 patients who were diagnosed or hospitalized at five facilities in Japan. Responses were obtained from 285 out of 1,150 patients. More than half of the participants reported Long COVID symptoms of varying severity 1 year after COVID-19. Common sequelae included fatigue, dyspnea, alopecia, concentration problems, memory problems, sleeplessness, and joint pain, which often significantly reduced their QOL. COVID-19 severity was strongly associated with sputum production, chest pain, dyspnea, sore throat, and diarrhea, but not with fatigue, dysgeusia, anosmia, alopecia, and sleeplessness. Fatigue, dysgeusia, anosmia, alopecia, and sleeplessness affected the QOL among participants with asymptomatic or mild COVID-19 during the acute phase. Moreover, these sequelae persisted for prolonged periods., (© 2022. The Author(s).)
- Published
- 2022
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39. Tinea amiantacea with Secondary Cicatricial Alopecia.
- Author
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Cerejeira A, Pedrosa A, and Azevedo F
- Subjects
- Humans, Alopecia complications, Cicatrix complications, Tinea Capitis, Pityriasis
- Published
- 2022
40. Chronic radiation dermatitis induced by cardiac catheterization: a case report and literature review.
- Author
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Cheng TT and Yang HJ
- Subjects
- Humans, Fluoroscopy adverse effects, Risk Factors, Alopecia complications, Cardiac Catheterization adverse effects, Radiodermatitis diagnosis, Radiodermatitis etiology, Radiodermatitis pathology
- Abstract
Fluoroscopy-induced chronic radiation dermatitis (FICRD) is an uncommon but increasing complication that is challenging to diagnose due to its varied symptoms and delayed onset, usually from months to years after radiation exposure. For patients undergoing cardiac catheterization, high-risk factors for radiodermatitis include obesity, the presence of complex or chronic total occlusion lesions, the use of a fixed large beam angulation, and a procedure time of more than 2 hours. We present an individual with FICRD that had an indurated plaque on his back for 7 years to familiarize physicians with high-risk groups and early recognition of the disease.
- Published
- 2022
41. Dystrophic xanthomization secondary to lichen planus pigmentosus associated with frontal fibrosing alopecia.
- Author
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Lobato-Berezo A, Gonzalez-Farré M, Marcantonio O, and Pujol RM
- Subjects
- Humans, Alopecia complications, Alopecia diagnosis, Hyperpigmentation diagnosis, Hyperpigmentation etiology, Lichen Planus complications, Lichen Planus diagnosis
- Published
- 2022
- Full Text
- View/download PDF
42. Response to the study by Collins et al "Retrospective review of adverse events associated with oral hydroxychloroquine use in patients with cicatricial alopecia."
- Author
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Klein EJ, Karim M, Lo Sicco K, and Shapiro J
- Subjects
- Humans, Retrospective Studies, Alopecia drug therapy, Alopecia complications, Cicatrix complications, Hydroxychloroquine adverse effects, Lichen Planus complications
- Abstract
Competing Interests: Conflicts of interest Dr Shapiro is a consultant for Aclaris Therapeutics, Incyte, and Replicel Life Sciences. Drs. Shapiro and Lo Sicco have been investigators for Regen Lab and are investigators for Pfizer. Authors Klein and Karim have no conflicts to declare.
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- 2022
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43. Reply to "Response to Collins et al.'s 'Retrospective review of adverse events associated with oral hydroxychloroquine use in patients with cicatricial alopecia'".
- Author
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Collins MS, Ezemma O, Devjani S, and Senna MM
- Subjects
- Humans, Retrospective Studies, Cicatrix pathology, Hydroxychloroquine adverse effects, Alopecia drug therapy, Alopecia complications
- Abstract
Competing Interests: Conflicts of interest None disclosed.
- Published
- 2022
- Full Text
- View/download PDF
44. PCOS and Depression: Common Links and Potential Targets.
- Author
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Kolhe JV, Chhipa AS, Butani S, Chavda V, and Patel SS
- Subjects
- Female, Humans, Hirsutism, Quality of Life, Androgens, Depression, Obesity complications, Alopecia complications, Alopecia epidemiology, Polycystic Ovary Syndrome complications, Polycystic Ovary Syndrome epidemiology, Polycystic Ovary Syndrome diagnosis, Insulin Resistance, Acne Vulgaris epidemiology, Acne Vulgaris etiology
- Abstract
PCOS or polycystic ovary syndrome is a common endocrine disorder that occurs during the reproductive age in females. It manifests in the form of a wide range of symptoms including (but not limited to) hirsutism, amenorrhea, oligomenorrhea, obesity, acne vulgaris, infertility, alopecia, and insulin resistance. The incidence of depression in PCOS population is increasing as compared to the general population. Increased depression in PCOS significantly alters the quality of life (QOL) of affected females. Also, self-esteem is found to be low in both depression and PCOS. The loss in self-esteem in such patients can be largely attributed to the associated factors including (but not limited to) obesity, acne, androgenic alopecia, and hirsutism. The reason behind the occurrence of depression in PCOS remains elusive to date. Literature suggests that there is an overlap of clinical symptoms between depression and PCOS. As the symptoms overlap, there is a possibility of common associations between depression, PCOS, and PCOS-associated abnormalities including insulin resistance (IR), obesity, CVD, and androgen excess. Studies demonstrate that depression is an inflammatory disorder marked with increased levels of inflammatory markers. On the other hand, PCOS is also regarded as a pro-inflammatory state that is characterized by increased levels of pro-inflammatory markers. Thus, there is a possibility of an inflammatory relationship existing between depression and PCOS. It is also possible that the inflammatory markers in PCOS can cross the blood-brain barrier (BBB) leading to the development of depression. Through the present review, we have attempted to shed light on common associations/shared links between depression and PCOS with respect to the levels of cortisol, androgen, vitamin D, neurotransmitters, monoaminoxidase (MAO), and insulin-like growth factor-1 (IGF-1). Tracking down common associations between depression and PCOS will help find potential drug therapies and improve the QOL of females with depression in PCOS., (© 2021. Society for Reproductive Investigation.)
- Published
- 2022
- Full Text
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45. A first case of childhood chronic inflammatory demyelinating polyneuropathy associated with alopecia universalis.
- Author
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Okubo Y, Miyabayashi T, Sato R, Endo W, Inui T, Togashi N, and Haginoya K
- Subjects
- Female, Humans, Child, Immunoglobulins, Intravenous therapeutic use, Muscle Weakness, Alopecia complications, Alopecia drug therapy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating complications, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating diagnosis, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating drug therapy, Alopecia Areata complications
- Abstract
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired demyelinating disease of the peripheral nervous system with unknown etiology. Alopecia universalis, an advanced form of alopecia areata (AA), is a condition characterized by complete hair loss. Here we report the first case of childhood CIDP associated with AA who was successfully treated with a combination of intravenous immunoglobulin (IVIg) and corticosteroids. CASE REPORT: This case describes a nine-year-old Japanese girl who developed alopecia, progressive muscle weakness, and eventually loss of walking ability (at ages 2, 4, and 7, respectively). She was treated with IVIg and prednisolone combination therapy, which improved muscle weakness and alopecia. She was positive for serum IgG-GM2 type anti-glycolipid antibodies, which may be associated with this rare combination of diseases., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2022
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46. Coexistence of vitiligo and frontal fibrosing alopecia: A case report and analysis of its physiopathology.
- Author
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Trujillo-Gaviria L, Gómez-Osorio D, Ruiz-Restrepo JD, and Valencia-Ocampo OJ
- Subjects
- Humans, Alopecia complications, Vitiligo complications, Hypopigmentation, Lichen Planus complications, Lichen Planus diagnosis
- Published
- 2022
- Full Text
- View/download PDF
47. Nonscarring Alopecia Secondary to Secukinumab.
- Author
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Tirelli LL, Alfaro A, Citera G, and Echeverría CM
- Subjects
- Humans, Cicatrix pathology, Alopecia chemically induced, Alopecia complications, Antibodies, Monoclonal, Humanized adverse effects
- Published
- 2022
- Full Text
- View/download PDF
48. Alopecia and hyperpigmentation in a neonatal patient with lanosterol synthase gene deficiency and Spectrin alpha, non-erythrocytic 1 mutation.
- Author
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Xiao TL and Rosenblatt AE
- Subjects
- Infant, Newborn, Humans, Alopecia genetics, Alopecia complications, Mutation, Spectrin genetics, Hyperpigmentation genetics, Hyperpigmentation complications
- Abstract
Lanosterol synthase is required for cholesterol synthesis, and deficiencies have been associated with hypotrichosis as well as neuroectodermal syndromes including intellectual delay and epilepsy. Here, we report a case of lanosterol synthase deficiency in a 4-day-old patient who presented with alopecia and a previously unreported dermatologic manifestation of congenital localized hyperpigmentation., (© 2022 The Authors. Pediatric Dermatology published by Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
49. Nonscarring Alopecia Secondary to Secukinumab.
- Author
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Tirelli LL, Alfaro A, Citera G, and Echeverría CM
- Subjects
- Humans, Alopecia chemically induced, Alopecia complications, Antibodies, Monoclonal, Humanized adverse effects
- Published
- 2022
- Full Text
- View/download PDF
50. [Hyperandrogenism after menopause: Ovarian or adrenal origin?]
- Author
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Sarfati J, Moraillon-Bougerolle M, and Christin-Maitre S
- Subjects
- Alopecia complications, Androgens, Androstenedione, Female, Follicle Stimulating Hormone, Humans, Menopause, Ovary, Progesterone, Testosterone, Adrenal Gland Neoplasms complications, Hyperandrogenism etiology
- Abstract
Postmenopausal hyperandrogenism is an androgen excess originating from either the adrenals and/or the ovaries. Clinically, symptoms can be moderate (increase in terminal hair growth, acnea) or severe with signs of virilization (alopecia, clitoridomegaly). In either setting, physicians need to exclude relatively rare but potentially life-threatening underlying tumorous causes, such as adrenal androgen-secreting tumors. The objectives of this review are to evaluate which hormonal measurements (T, delta 4 androstenedione, 17 OH progesterone, SDHEA, FSH, LH) and/or imaging (pelvic ultrasound, MRI or adrenal CT-scan) could be useful identifying the origin of the androgen excess. Our review illustrates that the rate of progression of hirsutism and/or alopecia, and serum testosterone levels are in favor of tumors. Pelvic MRI and adrenal CT-scan are useful tools for identifying the different causes of androgen excess., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
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