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13 results on '"Alonso-Calviño, Elena"'

4. Normal Cortical Myelination in Galectin-4-Deficient Mice

Author

Brocca, María Elvira, primary, Mora-Rubio, Arancha, additional, Alonso-Calviño, Elena, additional, Fernández-López, Elena, additional, Díez-Revuelta, Natalia, additional, Martos-Puñal, David, additional, Aguilar, Juan, additional, Higuero, Alonso M., additional, and Abad-Rodríguez, José, additional

Published
2022
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10. Protocol for stimulating specific rodent limb receptive fields while recording in vivosomatosensory-evoked activity.

Author

Zaforas, Marta, Miguel-Quesada, Claudia, Fernández-López, Elena, Alonso-Calviño, Elena, Barranco-Maresca, Verónica, Misol-Ortiz, Andrea, Aguilar, Juan, and Rosa, Juliana M.

Abstract

Studies on sensory information processing typically focus on whisker-related tactile information, overlooking the question of how sensory inputs from other body areas are processed at cortical levels. Here, we present a protocol for stimulating specific rodent limb receptive fields while recording in vivo somatosensory-evoked activity. We describe steps for localizing cortical-hindlimb coordinates using acute peripheral stimulation, electrode placement, and the application of electrical stimulation. This protocol overcomes the challenge of inducing a reproducible and consistent stimulation of specific limbs.

Published
2024
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13. Spinal Cord Injury Immediately Changes the State of the Brain.

Author

Aguilar, Juan, Humanes-Valera, Desiré, Alonso-Calviño, Elena, Yague, Josué G., Moxon, Karen A., Oliviero, Antonio, and Foffani, Guglielmo

Subjects
SPINAL cord injuries, BRAIN, CEREBRAL cortex, NEURAL stimulation, LABORATORY rats
Abstract

Spinal cord injury can produce extensive long-term reorganization of the cerebral cortex. Little is known, however, about the sequence of cortical events starting immediately after the lesion. Here we show that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats. Besides the obvious loss of cortical responses to hindpaw stimuli (below the level of the lesion), cortical responses evoked by forepaw stimuli (above the level of the lesion) markedly increase. Importantly, these increased responses correlate with a slower and overall more silent cortical spontaneous activity, representing a switch to a network state of slow-wave activity similar to that observed during slow-wave sleep. The same immediate cortical changes are observed after reversible pharmacological block of spinal cord conduction, but not after sham. We conclude that the deafferentation due to spinal cord injury can immediately (within minutes) change the state of large cortical networks, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury. [ABSTRACT FROM AUTHOR]

Published
2010
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