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2. 4CPS-058 Symbaloo as digital tool for haemophilia

Author

Martín López, A, primary, Ocaña Gómez, MÁ, additional, Joy Carmona, P, additional, Díaz Díaz, CL, additional, Esquivel Negrín, J, additional, Montero Delgado, JA, additional, Santos Fagundo, A, additional, Avanzini Martínez, G, additional, Merino Alonso, FJ, additional, Plasencia García, I, additional, and Álvarez Tosco, KI, additional

Published
2023
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5. Management and Long-term Outcomes of Crohn's Disease Complicated with Enterocutaneous Fistula: ECUFIT Study from GETECCU

Author

Barreiro-de Acosta, M, Riestra, S, Calafat, M, Soto, MP, Calvo, M, Rodriguez, ES, Caballol, B, Vela, M, Rivero, M, Munoz, F, de Castro, L, Calvet, X, Garcia-Alonso, FJ, Fornals, AU, Ferreiro-Iglesias, R, Gonzalez-Munoza, C, Chaparro, M, Bujanda, L, Sicilia, B, Alfambra, E, Rodriguez, A, Fernandez, RP, Rodriguez, C, Almela, P, Arguelles, F, Busquets, D, Tamarit-Sebastian, S, Castro, CR, Jimenez, L, Marin-Jimenez, I, Alcaide, N, Fernandez-Salgado, E, Iglesias, A, Ponferrada, A, Pajares, R, Roncero, O, Morales-Alvarado, VJ, Ispizua-Madariaga, N, Sainz, E, Merino, O, Marquez-Mosquera, L, Garcia-Sepulcre, M, Elorza, A, Estrecha, S, Suris, G, Van Domselaar, M, Brotons, A, de Francisco, R, Canete, F, Iglesias, E, Vera, MI, Mesonero, F, Lorente, R, Zabana, Y, Cabriada, JL, Domenech, E, Rodriguez-Lago, I, and Registry, ESGFTE

Subjects
surgery, Crohn's disease, enterocutaneous fistula, fistula
Abstract

Background and aims Crohn's disease [CD] can develop penetrating complications at any time during the disease course. Enterocutaneous fistulae [ECF] are disease-related complications with an important impact on quality of life. Our aim was to describe the outcomes of this complication, including its medical and/or surgical management and their temporal trends. The primary endpoint was fistula closure, defined as the absence of drainage, with no new abscess or surgery, over the preceding 6 months. Methods Clinical information from all adult patients with CD and at least one ECF-excluding perianal fistulae-were identified from the prospectively-maintained ENEIDA registry. All additional information regarding treatment for this complication was retrospectively reviewed. Results A total of 301 ECF in 286 patients [January 1970-September 2020] were analysed out of 30 088 records. These lesions were mostly located in the ileum [67%] and they had a median of one external opening [range 1-10]. After a median follow-up of 146 months (interquartile range [IQR], 69-233), 69% of patients underwent surgery. Fistula closure was achieved in 84%, mostly after surgery, and fistula recurrence was uncommon [13%]. Spontaneous and low-output fistulae were associated with higher closure rates (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.17-1.93, p = 0.001, and HR 1.49, 95% CI 1.07-2.06, p = 0.03, respectively); this was obtained more frequently with medical therapy since biologics have been available. Conclusions ECF complicating CD are rare but entail a high burden of medical and surgical resources. Closure rates are high, usually after surgery, and fistula recurrence is uncommon. A significant proportion of patients receiving medical therapy can achieve fistula closure.

Published
2022

6. Long-term outcomes of enterocutaneous fistula complicating Crohn's Disease: The ECUFIT study from GETECCU

Author

Rodriguez-Lago, I, Perez, CG, Calafat, M, Soto, MP, Calvo, M, Rodriguez, ES, Caballol, B, Vela, M, Rivero, M, Munnoz, F, De Castro, L, Calvet, X, Garcia-Alonso, FJ, Fornals, AU, Ferreiro-Iglesias, R, Gonzalez-Munoza, C, Chaparro, M, Luis, B, Sicilia, B, Alfambra, E, Rodriguez, A, Fernandez, RP, Rodriguez, C, Almela, P, Arguelles, F, Busquets, D, Tamarit-Sebastian, S, Castro, CR, Jimenez, L, Marin-Jimenez, I, Alcaide, N, Fernandez-Salgado, E, Gomez, AI, Ponferrada, A, Pajares, R, Roncero, O, Morales-Alvarado, VJ, Cabriada, JL, Domenech, E, and Barreiro-de Acosta, M

Published
2021

7. Long-term outcomes of biologic therapy in Crohn's disease complicated with internal fistulizing disease: BIOSCOPE study from GETECCU

Author

Rodriguez-Lago, I, Fernandez-Clotet, A, Mesonero, F, Garcia-Alonso, FJ, Casanova, MJ, Fernandez-de la Varga, M, Canete, F, de Castro, L, Gutierrez, A, Sicilia, B, Cano, V, Merino, O, Riestra, S, Gonzalez-Partida, I, Suris, G, Torrealba, L, Ferreiro-Iglesias, R, Castro, B, Marquez, L, Sobrino, A, Elorza, A, Calvet, X, Varela, P, Betore, E, Bujanda, L, Lario, L, Mancenido, N, Garcia-Sepulcre, M, Iglesias, E, Rodriguez, C, Piqueras, M, Rosique, JAF, Lucendo, A, Benitez, O, Garcia, M, Olivares, D, Gonzalez-Munoza, C, Cabriada, JL, Domenech, E, and Barreiro-de Acosta, N

Published
2021

8. Eus-Guided Gastroenterostomy (EUS-GE) For Gastric Outlet Obstruction (GOO) With A Lumen-Apposing Metal Stent (LAMS): Prospective Multicenter Procedural Standardization Of The Parallel Enteral Catheter (PEC) Method

Author

Chavarría, C, additional, Martín-Álvarez, V, additional, Aparicio, JR, additional, Subtil, JC, additional, Garcia Alonso, FJ, additional, Vila, JJ, additional, Martínez-Moreno, B, additional, Busto Bea, V, additional, de la Serna-Higuera, C, additional, and Perez-Miranda, M, additional

Published
2021
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10. Appropriate Treatment For Non-Pedunculated Colorectal Polyps > 20 MM According To Western And Eastern Approach: Conditional Inference-Tree From A Prospective Multicenter Cohort

Author

da Costa-Seixas, J, additional, López-Cerón, M, additional, Arnau, A, additional, Rosiñol, Ò, additional, Cuatrecasas, M, additional, Herreros-de-Tejada, A, additional, Ferrández, Á, additional, Serra-Burriel, M, additional, Nogales, Ó, additional, de Castro, L, additional, López-Vicente, J, additional, Vega, P, additional, Álvarez-González, MA, additional, González-Santiago, JM, additional, Hernández-Conde, M, additional, Díez-Redondo, P, additional, Rivero-Sánchez, L, additional, Gimeno-García, AZ, additional, Burgos, A, additional, García-Alonso, FJ, additional, Bustamante-Balén, M, additional, Martínez-Bauer, E, additional, Peñas, B, additional, Rodríguez-Alcalde, D, additional, Pellisé, M, additional, and Puig, I, additional

Published
2021
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11. Prospective and Multicenter Evaluation of the Impact Of Eus-Guided Gastroenterostomy (EUS-GE) On The Quality Of Life Of Patients With Malignant Gastric Outlet Obstruction (GOO)

Author

Garcia Alonso, FJ, additional, Martín-Álvarez, V, additional, Chavarria, C, additional, Aparicio, JR, additional, Martinez-Moreno, B, additional, Subtil, JC, additional, Vila, JJ, additional, Busto Bea, V, additional, de la Serna-Higuera, C, additional, and Perez-Miranda, M, additional

Published
2021
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15. LUMEN APPOSING METAL STENTS RELATED ADVERSE EVENTS. RESULTS FROM A NATIONWIDE PROSPECTIVE REGISTRY

Author

Bazaga, S, additional, Aparicio, JR, additional, Sanchiz, V, additional, Gornals, J, additional, Loras, C, additional, Pedraza, R, additional, Terán, A, additional, Vazquez-Sequeiros, E, additional, Vila, J, additional, Guardiola, A, additional, Guarner, C, additional, Huertas, C, additional, Garcia-Fernandez, F, additional, Bernad, B, additional, Perez, A, additional, Villanueva, R, additional, Gonzalez-Huix, F, additional, Pinto, I, additional, Vilella, A, additional, Castro, JL, additional, Colán, J, additional, Nuñez-Otero, J, additional, Subtil, JC, additional, Pérez-Carazo, L, additional, Couto, I, additional, Sanchez, E, additional, Uceda, F, additional, Martinez, B, additional, Garcia-Alonso, FJ, additional, de la Serna, C, additional, and Perez-Miranda, M, additional

Published
2020
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18. Accuracy of the Narrow-Band Imaging International Colorectal Endoscopic Classification System in Identification of Deep Invasion in Colorectal Polyps

Author

Puig, I, Lopez-Ceron, M, Arnau, A, Rosinol, O, Cuatrecasas, M, Herreros-de-Tejada, A, Ferrandez, A, Serra-Burriel, M, Nogales, O, Vida, F, de Castro, L, Lopez-Vicente, J, Vega, P, Alvarez-Gonzalez, MA, Gonzalez-Santiago, J, Hernandez-Conde, M, Diez-Redondo, P, Rivero-Sanchez, L, Gimeno-Garcia, AZ, Burgos, A, Garcia-Alonso, FJ, Bustamante-Balen, M, Martinez-Bauer, E, Penas, B, Pellise, M, EndoCAR Grp, Spanish Gastroenterological Assoc, and Spanish Digestive Endoscopy Soc

Subjects
Colon Cancer, Prognostic Factor, Early Detection, CRC
Abstract

BACKGROUND & AIMS: T1 colorectal polyps with at least 1 risk factor for metastasis to lymph node should be treated surgically and are considered endoscopically unresectable. Optical analysis, based on the Narrow-Band Imaging International Colorectal Endoscopic (NICE) classification system, is used to identify neoplasias with invasion of the submucosa that require endoscopic treatment. We assessed the accuracy of the NICE classification, along with other morphologic characteristics, in identifying invasive polyps that are endoscopically unresectable (have at least 1 risk factor for metastasis to lymph node). METHODS: We performed a multicenter, prospective study of data collected by 58 endoscopists, from 1634 consecutive patients (examining 2123 lesions) at 17 university and community hospitals in Spain from July 2014 through June 2016. All consecutive lesions >10 mm assessed with narrow-band imaging were included. The primary end point was the accuracy of the NICE classification for identifying lesions with deep invasion, using findings from histology analysis as the reference standard. Conditional inference trees were fitted for the analysis of diagnostic accuracy. RESULTS: Of the 2123 lesions analyzed, 89 (4.2%) had features of deep invasion and 91 (4.3%) were endoscopically unresectable. The NICE classification system identified lesions with deep invasion with 58.4% sensitivity (95% CI, 47.5-68.8), 96.4% specificity (95% CI, 95.5-97.2), a positive-predictive value of 41.6% (95% CI, 32.9-50.8), and a negative-predictive value of 98.1% (95% CI, 97.5-98.7). A conditional inference tree that included all variables found the NICE classification to most accurately identify lesions with deep invasion (P10 mm, we found the NICE classification and morphologic features identify those with deep lesions with >96% specificity-even in non-expert hands and without magnification. ClinicalTrials. gov number NCT02328066.

Published
2019

19. A retrospective, multicenter analysis of incidents associated with Axios (TM) lumen-apposing stents

Author

Bazaga Pérez de Rozas S, Carbajo AY, Garcia-Alonso FJ, Martí D, Sánchiz Soler V, Martinez B, Aparicio J, Pedraza Sanz R, Vila Costas J, Vázquez-Sequeiros E, Villanueva Hernández R, Jordán Castro JA, Jiménez Palacios M, de la Serna Higuera C, and Perez-Miranda Castillo M

Subjects
Complications, Axios (TM), Retrospective, Removal, Lumen-apposing stent
Abstract

Introduction: there is controversy with regard to the risks associated with lumen-apposing metal stents (LAMSs), with significant variations between available reports. Objectives: to describe the types and proportions of complications that arise during the permanence time and removal of Axios (TM) LAMS. Furthermore, the relationship between patency time, therapeutic target and the presence of complications was also described. Methods: a retrospective, multicenter case series study was performed of all patients with an implanted LAMS to access extra-luminal structures during 2017. Only technically successful cases were recorded. Results: a total of 179 patients from seven sites (range, 4-68 cases/site) were included in the study, with a mean age of 64.3 years (SD: 15.8; range: 24.6-98.8 years) and 122 (68.2%) were male. Most common indications included encapsulated necrosis (58, 32.4%), pseudocysts (31, 17.3%) and gallbladder drains (26, 14.5%). Complications during LAMS stay were reported in 19 patients (10.9%); stent lumen or gastroduodenal obstruction (8, 4.5%) and bleeding (7, 3.9%) were the most common. LAMS were not removed in 86 (48%) patients due to the following reasons: a permanent stent was used (46, 53.5%), loss to follow-up (18, 20.9%), patient demise (16, 18.6%) and stent migration (6, 7%). Five (5.4%) complications were reported during stent removal, which were three bleeds and two perforations. No association was found between stent duration and complications (p = 0.67). Conclusion: complications secondary to LAMS insertion are uncommon but may be serious. This study found no association between complications and stent duration.

Published
2019

20. Hemostatic spray powder TC-325 for GI bleeding in a nationwide study: survival and predictors of failure via competing risks analysis

Author

Rodríguez de Santiago E, Burgos-Santamaria D, Pérez-Carazo L, Brullet E, Ciriano L, Pons FR, Ángel de Jorge Turrión M, Prados S, Pérez-Corte D, Becerro-Gonzalez I, Martinez-Moneo E, Barturen A, Fernández-Urién I, López-Serrano A, Ferre-Aracil C, Lopez-Ibañez M, Carbonell C, Nogales O, Martínez-Bauer E, Lantarón ÁT, Pagano G, Vázquez-Sequeiros E, Albillos A, TC-325 collaboration project. Endoscopy group of the Spanish Association of Gast, García AG, Volpato N, Rodriguez-Escaja C, García-Alonso FJ, Sevilla-Ribota S, Marcos Prieto HM, Chavarría-Herbozo CM, Murcia O, Aranda-Hernández J, Borobia R, Lledó JG, Santander C, Coto D, Oyón D, Polo IO, González-Haba Ruíz M, Torres CF, De Benito Sanz M, Peñas B, Parejo S, Juzgado D, and Ibañez A

Abstract

Background and Aims: TC-325 (Hemospray, Cook Medical, Winston-Salem, NC) is an inorganic hemostatic powder recently approved by the U.S. Food and Drug Administration. This study aimed to examine the effectiveness, safety, and predictors of TC-325 failure in a large real-life cohort. Methods: This was a retrospective study conducted at 21 Spanish centers. All patients treated with TC-325 until September 2018 were included. The primary outcome was treatment failure, defined as failed intraprocedural hemostasis or recurrent bleeding within the first 30 postprocedural days. Secondary outcomes included safety and survival. Risk and predictors of failure were assessed via competing-risk models. Results: The cohort comprised 261 patients, of whom 219 (83.9%) presented with upper gastrointestinal bleeding (GIB). The most common causes were pepticulcer (28%), malignancy (18.4%), and therapeutic endoscopy-related GIB (17.6%). TC-325 was used as rescue therapy in 191 (73.2%) patients. The rate of intraprocedural hemostasis was 93.5% (95% confidence interval [CI], 90%-96%). Risks of TC-325 failure at postprocedural days 3, 7, and 30 were 21.1%, 24.6%, and 27.4%, respectively. On multivariate analysis, spurting bleeding (P = .004), use of vasoactive drugs (P = .02), and hypotension (P = .008) were independent predictors of failure. Overall 30-day survival was 81.9% (95% CI, 76%-86%) and intraprocedural hemostasis was associated with a better prognosis (adjusted hazard ratio, 0.29; P = .006). Two severe adverse events were noted. Conclusion: TC-325 was safe and effective for intraprocedural hemostasis in more than 90% of patients, regardless of the cause or site of bleeding and its use as rescue therapy. In this high-risk cohort treated with TC-325, the 30-day failure rate exceeded 25% and was highest with spurting bleeding or hemodynamic instability.

Published
2019

21. A retrospective, multicenter analysis of incidents associated with Axios™ lumen-apposing stents

Author

Bazaga Pérez de Rozas S, Carbajo AY, Garcia-Alonso FJ, Martí D, Sánchiz Soler V, Martínez Moreno B, Aparicio Tormo JR, Pedraza Sanz R, Vila Costas J, Vázquez-Sequeiros E, Villanueva Hernández R, Jordán Castro JA, Jiménez Palacios M, de la Serna Higuera C, and Perez-Miranda Castillo M

Subjects
Complications, Axios (TM), Retrospective, equipment and supplies, Removal, Lumen-apposing stent
Abstract

there is controversy with regard to the risks associated with lumen-apposing metal stents (LAMSs), with significant variations between available reports.

Published
2019

23. COMBINED RETROGRADE/ANTEGRADE ENDOSCOPIC APPROACH TO DISCONNECTED BILE-DUCT (DBD) AS A RESULT OF SEVERE POSTOPERATIVE INJURY

Author

de Benito, M, additional, Carbajo, AY, additional, Peñas-Herrero, I, additional, García-Alonso, FJ, additional, Bazaga, S, additional, Tejedor-Tejeda, J, additional, Sánchez-Ocaña, R, additional, De la Serna, C, additional, García-Pajares, F, additional, Almohalla, C, additional, Sánchez-Antolín, G, additional, and Pérez-Miranda, M, additional

Published
2019
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26. HEMOSPRAY FOR GASTROINTESTINAL BLEEDING: EFFECTIVENESS, PREDICTORS OF FAILURE AND SURVIVAL IN A NATIONWIDE STUDY

Author

Rodríguez de Santiago, E, additional, Burgos Santamaría, D, additional, Pérez Carazo, L, additional, Teran Lantaron, A, additional, Brullet, E, additional, Prados Leira, S, additional, Riu Pons, F, additional, Fernández-Urién Sainz, I, additional, Becerro González, I, additional, Angel de Jorge Turrión, M, additional, Ferre Aracil, C, additional, Rodríguez Escaja, C, additional, Perez Corte, D, additional, Volpato Machado, N, additional, Martínez Moneo, E, additional, García Alonso, FJ, additional, Chavarría Herbozo, CM, additional, Sevilla Ribota, S, additional, Borobia Sanchez, R, additional, Martínez Bauer, E, additional, Ciriano Hernández, L, additional, Barturen Barroso, A, additional, Santander Vaquero, C, additional, Guerrero García, A, additional, Prieto, HMM, additional, López Serrano, A, additional, López Ibañez, M, additional, Murcia Palomares, O, additional, Pagano, G, additional, Oyón Lara, D, additional, Froilan Torres, C, additional, Coto Ugarte, D, additional, González-Haba Ruíz, M, additional, de Benito Sanz, M, additional, Carbonell Blanco, C, additional, Nogales Rincón, O, additional, Ortiz Polo, I, additional, Juzgado de Lucas, D, additional, Parejo Carbonell, S, additional, Peñas García, B, additional, Aranda Hernández, J, additional, García Lledó, J, additional, Ibañez Pinto, A, additional, Vazquez Sequeiros, E, additional, and Albillos, A, additional

Published
2019
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34. TEMPORARY EUS-GUIDED ANASTOMOSES (TEA) AS THERAPEUTIC ACCESS FISTULAS (TAF) IN BENIGN BILIARY OBSTRUCTION (BBO) NOT AMENABLE TO ERCP: EMERGING APPLICATION OF EUS-GUIDED BILIARY DRAINAGE (EUS-BD)

Author

De Benito, M, additional, Yaiza Carbajo, A, additional, Bazaga, S, additional, Garcia-Alonso, FJ, additional, Sanchez-Ocaña, R, additional, Peñas-Herrero, I, additional, Garcia-Pajares, F, additional, De la Serna Higuera, C, additional, and Perez-Miranda, M, additional

Published
2019
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35. 5PSQ-001 Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid

Author

Mesa Expósito, R, primary, Díaz Ruiz, MDP, additional, Suárez González, M, additional, Tevar Afonso, E, additional, Navarro Dávila, MA, additional, González Rodríguez, A, additional, Pérez Hernández, F, additional, Diaz Diaz, CL, additional, González García, I, additional, and Merino Alonso, FJ, additional

Published
2019
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45. RETROSPECTIVE COHORT STUDY EVALUATING CLINICAL OUTCOMES OF PERCUTANEOUS AND ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF UPPER ABDOMINAL ABSCESSES

Author

Carbajo López, AY, additional, Brunie Vegas, FJ, additional, García Alonso, FJ, additional, Torres Yuste, R, additional, Cimavilla Román, M, additional, Sánchez-Ocaña, R, additional, Peñas-Herrero, I, additional, de la Serna-Higuera, C, additional, Fernández Pérez, GC, additional, and Pérez-Miranda, M, additional

Published
2018
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49. 6ER-029 Spanish hospital pharmacy twittersphere: a quantitative study

Author

Delgado, JA Montero, primary, Manuel, MS Jose, additional, Pourcq, JT de, additional, Paniagua, S Plata, additional, Romero, MM Viña, additional, García, I Plasencia, additional, Melini, E Gomez, additional, Santana, E Ramos, additional, Expósito, R Mesa, additional, Rojas, S Hernández, additional, and Alonso, FJ Merino, additional

Published
2018
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