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8. Dementia and glaucoma: Results from a Nationwide French Study between 2006 and 2018.

Author

Chamard, Chloé, Alonso, Sandrine, Carrière, Isabelle, Villain, Max, Arnould, Louis, Debourdeau, Eloi, Huguet, Héléna, Mura, Thibault, and Daien, Vincent

Subjects
*GLAUCOMA, *DEMENTIA, *INTRAOCULAR pressure, *DISEASE risk factors, *DATABASES, *DIABETIC retinopathy
Abstract

Purpose: Glaucoma is the leading cause of irreversible blindness worldwide. The brain and eye share many characteristics, so the eye may provide an easy‐access window on brain processes. The aim of the study was to evaluate the link between glaucoma as well as intraocular pressure (IOP)‐lowering drops load and all‐cause dementia. Methods: This was a nested case‐control study based on the French national healthcare database from 1 January 2006 to 31 December 2018in individuals aged ≥60 years. We compared cases of incident all‐cause dementia with 1:5 controls matched by date of case diagnosis (index date), age, sex, and income. We set a 5‐year exposure to glaucoma period ending 2 years before the index date (lag‐time period to avoid protopathic bias). The main outcome was glaucoma defined with hospitalization related to POAG and/or dispensations of IOP‐lowering drops. The secondary outcome was the IOP‐lowering drops load. Results: In total, 4810 incident all‐cause dementia and 24 050 matched controls were analysed (median [IQR] age 82 [10] years; 66.6% women). The prevalence of glaucoma was 14.0% in controls and cases. Risk of all‐cause dementia was not associated with glaucoma (crude OR, 1.02; 95% CI [0.93–1.11]; p = 0.7; adjusted OR, 0.99; 95% CI [0.91–1.09]; p = 0.9) or IOP‐lowering drops load (p = 0.2). Conclusion: The present study in general population ≥60 years old in France did not find any association between glaucoma and incident all‐cause dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Présentation clinique des patients souffrant de rachialgie inflammatoire chronique récente évocatrice de spondyloarthrite : la cohorte Desir

Author

Dougados, Maxime, Etcheto, Adrien, Molto, Anna, Alonso, Sandrine, Bouvet, Sophie, Daurès, Jean-Pierre, Landais, Paul, d’Agostino, Maria-Antonietta, Berenbaum, Francis, Breban, Maxime, Claudepierre, Pascal, Combe, Bernard, Fautrel, Bruno, Feydy, Antoine, Goupille, Philippe, Richette, Pascal, Pham, Thao, Roux, Christian, Tréluyer, Jean-Marc, Saraux, Alain, van der Heijde, Désirée, and Wendling, Daniel

Published
2015
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20. Personalized dietary advices provided by a dietitian increase calcium intake in outpatients with multiple sclerosis—Results from a randomized, controlled, single-blind trial

Author

Fiorella, Sandrine, primary, Agherbi, Hanane, additional, El Houjeiry, Emilia, additional, Castelnovo, Giovanni, additional, Renard, Dimitri, additional, Privat, Pauline, additional, Santamaria, Elodie, additional, Vallayer, Virginie, additional, Alonso, Sandrine, additional, Chevallier, Thierry, additional, Bancal, Candice, additional, Laurent-Chabalier, Sabine, additional, and Thouvenot, Eric, additional

Published
2023
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21. Clinical presentation of patients suffering from recent onset chronic inflammatory back pain suggestive of spondyloarthritis: The DESIR cohort

Author

Dougados, Maxime, Etcheto, Adrien, Molto, Anna, Alonso, Sandrine, Bouvet, Sophie, Daurès, Jean-Pierre, Landais, Paul, d’Agostino, Maria-Antonietta, Berenbaum, Francis, Breban, Maxime, Claudepierre, Pascal, Combe, Bernard, Fautrel, Bruno, Feydy, Antoine, Goupille, Philippe, Richette, Pascal, Pham, Thao, Roux, Christian, Treluyer, Jean-Marc, Saraux, Alain, van der Heijde, Désirée, and Wendling, Daniel

Published
2015
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24. Association between brain metabolism and clinical course of motor functional neurological disorders

Author

Conejero, Ismael, primary, Collombier, Laurent, additional, Lopez-Castroman, Jorge, additional, Mura, Thibault, additional, Alonso, Sandrine, additional, Olié, Emilie, additional, Boudousq, Vincent, additional, Boulet, Fabrice, additional, Arquizan, Caroline, additional, Boulet, Charlotte, additional, Wacongne, Anne, additional, Heitz, Camille, additional, Castelli, Christel, additional, Mouchabac, Stéphane, additional, Courtet, Philippe, additional, Abbar, Mocrane, additional, and Thouvenot, Eric, additional

Published
2022
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27. Post‐operative opioid‐related adverse events with intravenous oxycodone compared to morphine: A randomized controlled trial

Author

Cuvillon, Philippe, primary, Alonso, Sandrine, additional, L’Hermite, Joel, additional, Reubrecht, Vanessa, additional, Zoric, Lana, additional, Vialles, Nathalie, additional, Luc Faillie, Jean, additional, Kouyoumdjian, Pascal, additional, Boisson, Christope, additional, Raux, Mathieu, additional, and Langeron, Olivier, additional

Published
2020
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29. Intravenous oxycodone compared to morphine for post-operative opioid-related adverse events in opioid naïve patients: a prospective randomized controlled trial

Author

cuvillon, philippe, primary, Alonso, Sandrine, additional, Lhermite, Joel, additional, Reubrecht, Vanessa, additional, Zoric, Lana, additional, Vialees, Nathalie, additional, faillie, jean-luc., additional, Kouyoumdjian, Pascal, additional, Boisson, Christope, additional, raux, mathieu, additional, and langeron, olivier, additional

Published
2020
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31. Inertial measurement unit compared to an optical motion capturing system in post-stroke individuals with foot-drop syndrome

Author

Feuvrier, François, Sijobert, Benoît, Froger, Jérome, Azevedo Coste, Christine, Griffiths, Karolina M., Alonso, Sandrine, Dupeyron, Arnaud, Laffont, Isabelle, Froger, Jérôme, Hôpital Universitaire de Réadaptation, de Rééducation et d'Addictologie du CHU de Nîmes [Grau-du-Roi] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Control of Artificial Movement and Intuitive Neuroprosthesis (CAMIN), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Unité de Rééducation Neurologique, Centre Hélio-Marin CHU Nîmes, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), BESPIM, Euromov (EuroMov), Université de Montpellier (UM), CCSD, Accord Elsevier, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM)

Subjects
Male, 030506 rehabilitation, Foot drop, Pilot Projects, 0302 clinical medicine, Accelerometry, Orthopedics and Sports Medicine, Prospective Studies, Range of Motion, Articular, Stroke, Gait, Foot-drop, Aged, 80 and over, Rehabilitation, Stroke Rehabilitation, Syndrome, Middle Aged, Functional electrostimulation, Biomechanical Phenomena, medicine.anatomical_structure, Inertial measurement unit, Female, medicine.symptom, 0305 other medical science, Gait Analysis, Algorithms, medicine.medical_specialty, Correlation coefficient, Mean squared error, Electric Stimulation Therapy, [SPI.AUTO]Engineering Sciences [physics]/Automatic, 03 medical and health sciences, Motion, Physical medicine and rehabilitation, Spatio-Temporal Analysis, medicine, Functional electrical stimulation, Humans, Gait Disorders, Neurologic, Aged, business.industry, Foot, Reproducibility of Results, medicine.disease, [SPI.AUTO] Engineering Sciences [physics]/Automatic, Kinematic parameters, Ankle, business, human activities, 030217 neurology & neurosurgery, Arithmetic mean
Abstract

Functional electrical stimulation (FES) can be used for compensation of foot-drop for post-stroke individuals by pre-programmed fixed stimulation; however, this stimulation seems no more effective than mechanical ankle foot orthoses.We evaluated the metrological quality of inertial sensors for movement reconstruction as compared with the gold-standard motion capturing system, to couple FES with inertial sensors to improve dorsiflexion on the paretic side, by using an adaptive stimulation taking into account individuals' performance post-stroke.Adults with ischemic or hemorrhagic stroke presenting foot-drop and able to walk 10m, were included from May 2016 to June 2017. Those with passive ankle dorsiflexion0° with the knee stretched were excluded. Synchronous gait was analyzed with the VICON© system as the gold standard and inertial measurement units (IMUs) worn by participants. The main outcome was the dorsiflexion angle at the heel strike and mid-swing phase obtained from IMUs and the VICON system. Secondary outcomes were: stride length, walking speed, maximal ankle dorsiflexion velocity and fatigue detection.We included 26 participants [18 males; mean age 58 (range 45-84) years]. During heel strike, the dorsiflexion angle measurements demonstrated a root mean square error (RMSE) of 5.5°; a mean average error (MAE) of 3.9°; Bland-Altman bias of -0.1° with limits of agreement -10.9° to+10.7° and good intra-class correlation coefficient (ICC) at 0.87 between the 2 techniques. During the mid-swing phase, the RMSE was 5.6; MAE 3.7°; Bland-Altman bias -0.9° with limits of agreement -11.7° to+9.8° and ICC 0.88. Good agreement was demonstrated for secondary outcomes and fatigue detection.IMU-based reconstruction algorithms were effective in measuring ankle dorsiflexion with small biases and good ICCs in adults with ischemic or hemorrhagic stroke presenting foot-drop. The precision obtained is sufficient to observe the fatigue influence on the dorsiflexion and therefore to use IMUs to adapt FES.

Published
2018

32. Intravenous oxycodone compared to morphine for post-operative opioid-related adverse events in opioid naïve patients: a prospective randomized controlled trial

Author

cuvillon, philippe, primary, Alonso, Sandrine, additional, L’Hermite, Joel, additional, Reubrecht, Vanessa, additional, Zoric, Lana, additional, Vialles, Nathalie, additional, Faillie, Jean Luc, additional, Kouyoumdjian, Pascal, additional, Boisson, Christope, additional, Raux, Mathieu, additional, and Langeron, Olivier, additional

Published
2019
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36. Post‐operative opioid‐related adverse events with intravenous oxycodone compared to morphine: A randomized controlled trial.

Author

Cuvillon, Philippe, Alonso, Sandrine, L'Hermite, Joel, Reubrecht, Vanessa, Zoric, Lana, Vialles, Nathalie, Luc Faillie, Jean, Kouyoumdjian, Pascal, Boisson, Christope, Raux, Mathieu, and Langeron, Olivier

Subjects
*OXYCODONE, *POSTOPERATIVE pain treatment, *RANDOMIZED controlled trials, *TOTAL hip replacement, *MORPHINE
Abstract

Background: The value of intravenous oxycodone compared to morphine remains controversial. The purpose of this trial was to compare opioid‐related adverse events (ORAES) of intravenous oxycodone and morphine after total hip arthroplasty. Methods: Patients scheduled for total hip arthroplasty were enrolled in this study of post‐operative pain treatment with intravenous oxycodone or intravenous morphine (ratio 1:1). After surgery, patients received similar drug regimens for titration in the post‐operative care unit followed by intravenous patient‐controlled analgesia (PCA). The primary outcome was the number of patients with ≥1 ORAEs within the first 24 hours defined as either nausea, vomiting, respiratory depression, pruritus, urinary retention requiring evacuation, allergy, hallucinations. Secondary outcomes included pain scores and opioid consumption. Results: The analysis included 238 patients with similar characteristics. There were 55 patients with at least one ORAEs in the oxycodone group vs 46 in the morphine group: 48% vs 40%, P =.19; relative risk = 1.22 (0.91:1.63). Intravenous oxycodone vs intravenous morphine requirements were respectively (median, IQR): 6 (0‐11) vs 8 (0‐12) mg (P =.06) for titration, 15 (8‐26) vs 8 (5‐16) mg (P =.001) for PCA, and 22 (12‐37) mg vs 19 (11‐28) mg for cumulated intravenous consumption (P =.048). During the first 24 hours, there was no difference in secondary outcomes (oxycodone vs morphine, respectively, in %): nausea (15 vs 13), vomiting (5 vs 5), urinary retention (20 vs 12) or pain scores. Conclusion: This study demonstrates that IV oxycodone did not significantly reduce ORAEs within the first 24 hours compared to similar ratio of IV morphine. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Back Belief Questionnaire--French Version

Author

Dupeyron, Arnaud, primary, Lanhers, Charlotte, additional, Bastide, Sophie, additional, Alonso, Sandrine, additional, Toulotte, Matthias, additional, Jourdan, Claire, additional, and Coudeyre, Emmanuel, additional

Published
2017
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42. Assessment of Neutrophil Gelatinase-associated Lipocalin in the Brain-dead Organ Donor to Predict Immediate Graft Function in Kidney Recipients

Author

Muller, Laurent, Nicolas-Robin, Armelle, Bastide, Sophie, Martinez, Orianne, Louart, Guillaume, Colavolpe, Jean-Christian, Vachiery, Florence, Alonso, Sandrine, Lefrant, Jean-Yves, Riou, Bruno, Group, Azurea, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Génétique, pharmacologie et physiopathologie des maladies cardiovasculaires, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), BESPIM, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service d'anesthésie et de réanimation [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
Brain dead, medicine.medical_specialty, Kidney, business.industry, Donor selection, Incidence (epidemiology), Urology, Lipocalin, Neutrophil gelatinase-associated lipocalin, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Multicenter study, Immunology, Medicine, Organ donation, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background: Delayed graft function is a major determinant of long-term renal allograft survival. Despite considerable efforts to improve donor selection and matching, incidence of delayed graft function remains close to 25%. As neutrophil gelatinase-associated lipocalin (NGAL) has been shown to predict acute renal failure, the authors tested the hypothesis that NGAL measurement in brain-dead donors predicts delayed graft function in kidney recipients. Methods: In a prospective, multicenter, observational study, serum NGAL was measured in donors at the time of transfer to operating room. The primary endpoint was the delayed graft function, defined as the need for renal replacement therapy during the first week posttransplantation. Results: Among 159 included brain-dead donors, 146 were analyzable leading to 243 renal transplantations. Of these, 56 (23%) needed renal replacement therapy. Donors’ NGAL values were similar in case of both delayed and normal graft function in recipients. The area under the receiver-operating curve for NGAL to predict the need for renal replacement therapy before day 8 was 0.50 (95% CI, 0.42 to 0.59). The area under curve for NGAL to predict failure to return to a normal graft function at day 8 was 0.51 (95% CI, 0.44 to 0.59). Using multivariate analysis, NGAL was not associated to the need for renal replacement therapy (odds ratio, 0.99; 95% CI, 0.98 to1.00) or failure to return to a normal graft function at day 8 (odds ratio, 1.00; 95% CI, 0.99 to 1.00). Conclusion: NGAL measurement in brain-dead donors at the time of recovery failed to predict delayed or normal graft function in kidney recipients.

Published
2015

45. Influence of Diaphragmatic Motion on Inferior Vena Cava Diameter Respiratory Variations in Healthy Volunteers

Author

Gignon, Lucile, primary, Roger, Claire, additional, Bastide, Sophie, additional, Alonso, Sandrine, additional, Zieleskiewicz, Laurent, additional, Quintard, Hervé, additional, Zoric, Lana, additional, Bobbia, Xavier, additional, Raux, Mathieu, additional, Leone, Marc, additional, Lefrant, Jean-Yves, additional, and Muller, Laurent, additional

Published
2016
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49. Performances of Four Real-Time PCR Assays for Diagnosis of Pneumocystis jiroveciiPneumonia

Author

Sasso, Milène, Chastang-Dumas, Elsa, Bastide, Sophie, Alonso, Sandrine, Lechiche, Catherine, Bourgeois, Nathalie, and Lachaud, Laurence

Abstract

ABSTRACTPneumonia due to Pneumocystis jirovecii(PCP) is a frequent infection among HIV-positive or other immunocompromised patients. In the past several years, PCR on pulmonary samples has become an essential element for the laboratory diagnosis of PCP. Nevertheless, very few comparative studies of available PCR assays have been published. In this work, we evaluated the concordance between four real-time PCR assays, including three commercial kits, AmpliSens, MycAssay, and Bio-Evolution PCR, and an in-house PCR (J. Fillaux et al. 2008, J Microbiol Methods 75:258–261, doi:http://dx.doi.org/10.1016/j.mimet.2008.06.009), on 148 pulmonary samples. The results showed concordance rates ranging from 81.6% to 96.6% (kappa, 0.64 to 0.93). Concordance was excellent between three assays: the in-house assay, AmpliSens, and the MycAssay PCR (kappa, >0.8). The performances of these PCR assays were also evaluated according to the classification of the probability of PCP (proven, probable, possible, or no final diagnosis of PCP) based on clinical and radiological signs as well as on the direct examination of bronchoalveolar lavage samples. In the proven PCP category, Pneumocystis jiroveciiDNA was detected with all four assays. In the probable PCP category, the in-house PCR, AmpliSens, and the MycAssay PCR were positive for all samples, while the Bio-Evolution PCR failed to detect Pneumocystis jiroveciiDNA in two samples. In the possible PCP category, the percentage of positive samples according to PCR varied from 54.5% to 86.4%. Detection of colonized patients is discussed. Finally, among the four evaluated PCR assays, one was not suitable for colonization detection but showed good performance in the proven and probable PCP groups. For the three other assays, performances were excellent and allowed detection of a very low fungal burden.

Published
2015
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50. Heterotaxia syndrome and autosomal dominant inheritance

Author

Alonso, Sandrine, primary, Pierpont, Mary Ella, additional, Radtke, Wolfgang, additional, Martinez, José, additional, Chen, Su-Chiung, additional, Grant, James W., additional, Dähnert, Ingo, additional, Taviaux, Sylvie, additional, Romey, Marie-Catherine, additional, Demaille, Jacques, additional, and Bouvagnet, Patrice, additional

Published
1995
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