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4. Hexageneration Project

Author

Winter-Althaus, Gabriel, Pulido-Alonso, Antonio, Trujillo, Lourdes, Rosales-Asensio, Enrique, Winter-Althaus, Gabriel, Pulido-Alonso, Antonio, Trujillo, Lourdes, and Rosales-Asensio, Enrique

Published
2023
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5. Technology Description

Author

Winter-Althaus, Gabriel, Pulido-Alonso, Antonio, Trujillo, Lourdes, Rosales-Asensio, Enrique, Winter-Althaus, Gabriel, Pulido-Alonso, Antonio, Trujillo, Lourdes, and Rosales-Asensio, Enrique

Published
2023
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17. Transient hysteresis and inherent stochasticity in gene regulatory networks

Author

Pájaro, Manuel, Otero-Muras, Irene, Vázquez, Carlos, and Alonso, Antonio A.

Subjects
Quantitative Biology - Molecular Networks, Mathematics - Dynamical Systems, 34C55 60H35 60G10 62P10 93E03
Abstract

Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. The classical deterministic picture for cell fate determination includes bistability and hysteresis, which enables the persistence of the acquired cellular state after withdrawal of the stimulus, ensuring a robust cellular response. However, the stochasticity inherent to gene expression dynamics is not compatible with hysteresis, since the stationary solution of the governing Chemical Master Equation does not depend on the initial conditions. In this work, we provide a quantitative description of a transient hysteresis phenomenon that reconciles experimental evidence of hysteretic behaviour in gene regulatory networks with their inherent stochasticity. Under sufficiently slow dynamics, the dependency of the non-stationary solutions on the initial state of the cells can lead to what we denote here as transient hysteresis. To quantify this phenomenon, we provide an estimate of the convergence rate to the equilibrium. We also introduce the equation of a natural landscape capturing the evolution of the system that, unlike traditional cell fate potential landscapes, is compatible with the notion of coexistence at the microscopic level., Comment: 35 pages, 13 figures

Published
2018
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18. Technology Description

Author

Winter-Althaus, Gabriel, primary, Pulido-Alonso, Antonio, additional, Trujillo, Lourdes, additional, and Rosales-Asensio, Enrique, additional

Published
2023
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19. Hexageneration Project

Author

Winter-Althaus, Gabriel, primary, Pulido-Alonso, Antonio, additional, Trujillo, Lourdes, additional, and Rosales-Asensio, Enrique, additional

Published
2023
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27. Wastewater and marine bioindicators surveillance to anticipate COVID-19 prevalence and to explore SARS-CoV-2 diversity by next generation sequencing: One-year study

Author

Novoa, Beatriz, Ríos-Castro, Raquel, Otero-Muras, Irene, Gouveia, Susana, Cabo, Adrián, Saco, Amaro, Rey-Campos, Magalí, Pájaro, Manuel, Fajar, Noelia, Aranguren, Raquel, Romero, Alejandro, Panebianco, Antonella, Valdés, Lorena, Payo, Pedro, Alonso, Antonio A., Figueras, Antonio, and Cameselle, Claudio

Published
2022
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28. MusselCF, a user-friendly toolbox to estimate the physiological carbon footprint of mussels in suspended aquaculture

Author

European Commission, Pájaro Diéguez, Manuel [0000-0001-7340-9737], Fuentes-Santos, I. [0000-0002-3298-9648], Labarta, Uxío [0000-0002-6963-1965], Alonso, Antonio A. [0000-0001-8203-1799], Álvarez-Salgado, Xosé Antón [0000-0002-2387-9201], Pájaro Diéguez, Manuel, Fuentes-Santos, I., Labarta, Uxío, Alonso, Antonio A., Álvarez-Salgado, Xosé Antón, European Commission, Pájaro Diéguez, Manuel [0000-0001-7340-9737], Fuentes-Santos, I. [0000-0002-3298-9648], Labarta, Uxío [0000-0002-6963-1965], Alonso, Antonio A. [0000-0001-8203-1799], Álvarez-Salgado, Xosé Antón [0000-0002-2387-9201], Pájaro Diéguez, Manuel, Fuentes-Santos, I., Labarta, Uxío, Alonso, Antonio A., and Álvarez-Salgado, Xosé Antón

Abstract

Interest on the potential CO2 sequestration of marine bivalve aquaculture has increased during the last decade. However, there is still some controversy about which biological processes are involved and how to estimate their contribution to the carbon footprint of bivalve aquaculture. This work considers the dissolved inorganic carbon, CO2 and alkalinity fluxes linked to flesh and shell growth, calcification, respiration, faeces egestion, and ammonia excretion, accounting also for the RDOC production associated to these processes. We have developed an algorithm for a dynamic estimation of these fluxes based on a net production DEB growth model for mussels. The resulting model has been implemented in Python to create a toolbox with a graphical user interface. This toolbox allows the selection of different culture strategies, in terms of seeding date, seed size and culture length, and consequently analyzes the carbon footprint and impact on the carbonate chemistry of seawater of aquaculture management

Published
2024

30. Evaluation of a Great Agrovoltaic Implementation in an Isle Using SWOT and TOWS Matrices: Case Study of Gran Canaria Island (Spain).

Author

Pulido-Alonso, Antonio, Quintana-Suárez, José C., Rosales-Asensio, Enrique, Feo-García, José J., and Florido-Suárez, Néstor R.

Subjects
WATER shortages, FARMS, UNEMPLOYMENT statistics, ECOLOGICAL impact, SWOT analysis
Abstract

Nowadays, we are heading towards global decarbonisation, with each sector involved contributing partial solutions to the problem, without realising that an overall vision is necessary. Photovoltaics emerged as a technology that requires a lot of surface area, which is why it has been integrated into buildings and other human infrastructures (BPVI). The effects of the implementation of AVS on an island have been analysed, observing the territory's energy use, population, and social and topographical realities, collecting all the peculiarities that could be affected by a massive implementation of this technology. The method to be followed is a SWOT and TOWS analysis, widely employed in all types of scientific studies. The increase in the island's resilience has been assessed, as has its decreasing its dependence on the outside. In this case, it has been observed that conventional PV is currently being installed on agricultural land to decarbonise electricity production, which mostly relies on oil and does not consider that the island is a territory with a high food dependence on the outside; a high unemployment rate; a high factor of soil desertification, meaning fires are frequent; a high rate of abandonment of agricultural land; and a shortage of flat land. Therefore, we affirm that the island's carbon footprint will increase by not taking all these factors into account. In addition to punishing the local economy by destroying fertile soil, local food and jobs, the current method of energy production increases the need for subsidies to import food products from abroad. In addition, we claim that the use of AVS reduces the water needs of the crop, which is relevant on an island with great water scarcity. It is concluded that 11 of the 17 UN Sustainable Development Goals would be improved with the use of agrovoltaic technology. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Study and Characterisation of Bimetallic Structure (316LSI and S275JR) Made by Hybrid CMT WAAM Process.

Author

Pereira, Alejandro, Alonso, Antonio, Hernández, Primo, Martínez, Javier, Alvarez, David, and Wieczorowski, Michal

Subjects
*FILLER materials, *TENSILE tests, *STRUCTURAL steel, *INDUSTRIAL costs, *MATERIALS testing
Abstract

The main objective of this research is to conduct an experimental investigation of the bimetallic material formed by 316LSI stainless steel and S275JR structural steel, produced via hybrid wire arc additive manufacturing technology with cool metal transfer welding and machining, and with the objective of being able to reduce the industrial cost of certain requirements for one of the materials. A methodological investigation has been carried out starting with welding beads of 316LSI on S275JR plates, followed by overlapping five beads and conducting final experiments with several vertical layers, with or without intermediate face milling. The results achieved optimal bead conditions for wire speeds of 4 m/min and 5 m/min at a travel speed of 400 mm/min. Overlap experiments show that the best deposition results are obtained with an overlap equal to or greater than 28%. Cooling time does not significantly influence the final geometry of the coatings. Regarding metallographic analysis, the filler material presents an austenitic columnar structure. In the base material, a bainitic structure with inferred grain refinement was detected in the heat-affected zone. An increase in hardness is observed in the heat-affected zone. In the results obtained from the tensile tests of the bimetallic material, an increase in mechanical strength and yield strength is observed in the tested specimens. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Uniqueness of feasible equilibria for mass action law (MAL) kinetic systems

Author

Alonso, Antonio A. and Szederkenyi, Gabor

Subjects
Quantitative Biology - Molecular Networks, 80A30, 92C42, G.1.7
Abstract

This paper studies the relations among system parameters, uniqueness, and stability of equilibria, for kinetic systems given in the form of polynomial ODEs. Such models are commonly used to describe the dynamics of nonnegative systems, with a wide range of application fields such as chemistry, systems biology, process modeling or even transportation systems. Using a flux-based description of kinetic models, a canonical representation of the set of all possible feasible equilibria is developed. The characterization is made in terms of strictly stable compartmental matrices to define the so-called family of solutions. Feasibility is imposed by a set of constraints, which are linear on a log-transformed space of complexes, and relate to the kernel of a matrix, the columns of which span the stoichiometric subspace. One particularly interesting representation of these constraints can be expressed in terms of a class of monotonous decreasing functions. This allows connections to be established with classical results in CRNT that relate to the existence and uniqueness of equilibria along positive stoichiometric compatibility classes. In particular, monotonicity can be employed to identify regions in the set of possible reaction rate coefficients leading to complex balancing, and to conclude uniqueness of equilibria for a class of positive deficiency networks. The latter result might support constructing an alternative proof of the well-known deficiency one theorem. The developed notions and results are illustrated through examples.

Published
2015
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41. Alternative CPAP methods for the treatment of secondary serious respiratory failure due to pneumonia by COVID-19

Author

Mateos-Rodríguez, Alonso, Ortega-Anselmi, Justo, Candel-González, Francisco Javier, Canora-Lebrato, Jesús, Fragiel-Saavedra, Marcos, Hernández-Píriz, Alba, Behzadi-Koocahni, Navid, González-del Castillo, Juan, Pérez-Alonso, Antonio, de la Cruz-Conty, María Luisa, García-de Casasola, Gonzalo, Marco-Martínez, Javier, and Zapatero-Gaviria, Antonio

Published
2021
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42. Métodos alternativos de CPAP para el tratamiento de insuficiencia respiratoria grave secundaria a neumonía por COVID-19

Author

Mateos-Rodríguez, Alonso, Ortega-Anselmi, Justo, Candel-González, Francisco Javier, Canora-Lebrato, Jesús, Fragiel-Saavedra, Marcos, Hernández-Píriz, Alba, Behzadi-Koocahni, Navid, González-del Castillo, Juan, Pérez-Alonso, Antonio, de la Cruz-Conty, María Luisa, García-de Casasola, Gonzalo, Marco-Martínez, Javier, and Zapatero-Gaviria, Antonio

Published
2021
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45. A Flexible Multilevel System for Mitre ATT&CK Model-driven Alerts and Events Correlation in Cyberattacks Detection.

Author

Muñoz-Calle, Javier, Alonso, Rafael Estepa, Estepa Alonso, Antonio, Díaz-Verdejo, Jesús E., Castillo Fernández, Elvira, and Madinabeitia, Germán

Abstract

Network monitoring systems can struggle to detect the full sequence of actions in a multi-step cyber attack, frequently resulting in multiple alerts (some of which are false positive (FP)) and missed actions. The challenge of easing the job of security analysts by triggering a single and accurate alert per attack requires developing and evaluating advanced event correlation techniques and models that have the potential to devise relationships between the different observed events/alerts. This work introduces a flexible architecture designed for hierarchical and iterative correlation of alerts and events. Its key feature is the sequential correlation of operations targeting specific attack episodes or aspects. This architecture utilizes IDS alerts or similar cybersecurity sensors, storing events and alerts in a non-relational database. Modules designed for knowledge creation then query these stored items to generate meta-alerts, also stored in the database. This approach facilitates creating a more refined knowledge that can be built on top of existing one by creating specialized modules. For illustrative purposes, we make a case study where we use this architectural approach to explore the feasibility of monitoring the progress of attacks of increased complexity by increasing the levels of the hyperalerts defined, including a case of a multi-step attack that adheres to the ATT&CK model. Although the mapping between the observations and the model components (i.e., techniques and tactics) is challenging, we could fully monitor the progress of two attacks and up to 5 out of 6 steps of the most complex attack by building up to three specialized modules. Despite some limitations due to the sensors and attack scenarios tested, the results indicate the architecture's potential for enhancing the detection of complex cyber attacks, offering a promising direction for future cybersecurity research. [ABSTRACT FROM AUTHOR]

Published
2024
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46. The first GHEP-ISFG collaborative exercise on forensic applications of massively parallel sequencing

Author

Barrio, Pedro A., García, Óscar, Phillips, Christopher, Prieto, Lourdes, Gusmão, Leonor, Fernández, Coro, Casals, Ferran, Freitas, Jorge M., González-Albo, María del Carmen, Martín, Pablo, Mosquera, Ana, Navarro-Vera, Isabel, Paredes, Manuel, Pérez, Juan Antonio, Pinzón, Andrea, Rasal, Raquel, Ruiz-Ramírez, Jorge, Trindade, Bruno R., and Alonso, Antonio

Published
2020
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