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107 results on '"Almudena Castro"'

1. Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING‐HF trial

Author: Patricia Palau, Laura López, Eloy Domínguez, Rafael de LaEspriella, Raquel Campuzano, Almudena Castro, Gema Miñana, Agustin Fernández‐Cisnal, Juan Sanchis, and Julio Núñez
Subjects: Aerobic capacity, Heart failure with preserved ejection fraction, Iron deficiency, peakVO2, Physical therapies, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
Abstract: Abstract Background Iron deficiency (ID) is associated with impaired functional capacity in patients with heart failure (HF), even in those with preserved ejection fraction (HFpEF). This study aimed to evaluate the effect of baseline ferrokinetics on peak oxygen consumption (peakVO2) improvement after a 12‐week physical therapy programme in patients with stable HFpEF. Methods This study is a post‐hoc sub‐analysis of a randomized clinical trial in which 59 stable patients with HFpEF were randomized to receive a 12‐week programme of inspiratory muscle training (IMT), functional electrical stimulation (FES), IMT + FES or usual care (UC) to evaluate change in peakVO2 (NCT02638961). Serum ferritin and transferrin saturation (TSAT) determinations were assessed at baseline. ID was defined as ferritin
Published: 2024
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2. Desaturación provocada por el ejercicio asociada a foramen, ¿infrecuente o infradiagnosticada?

Author: Víctor M. Juárez Olmos, Óscar González-Fernández, Alfonso Jurado Román, Santiago Jiménez Valero, Cristina Contreras Lorenzo, and Almudena Castro Conde
Subjects: Internal medicine, RC31-1245
Abstract: Sr. Editor: El foramen oval permeable (FOP) se encuentra presente en aproximadamente 1 de cada 4 personas, y para la gran mayoría de ellas no tiene consecuencias clínicas1; en otras, en cambio, puede favorecer la aparición de ictus, migrañas o síndrome de descompresión o desaturación con el ortostatismo (conocido como síndrome de platipnea-ortodesoxia)2. Una presentación todavía más infrecuente del FOP que se puede desarrollar en la edad adulta es la desaturación provocada por el ejercicio, descrita en pocas revisiones bibliográficas y con un término no totalmente acuñado3,4. Se presenta el caso de una mujer de 79 años con antecedentes de hipertensión y diabetes que es remitida a la unidad de rehabilitación cardiaca por disnea y pobre capacidad funcional. La paciente acudió con un estudio previo sin hallazgos significativos: ecocardiograma transtorácico, pruebas de función respiratoria, angiotomografía computarizada pulmonar y cateterismo coronario. En la exploración física destacaba una saturación de oxígeno del 98%. La analítica sanguínea era normal, con una fracción N-terminal del propéptido natriurético cerebral tipo B de 255 pg/ml. Cuando entró a la consulta refirió disnea de esfuerzo que apareció en el trayecto desde la sala de espera. Ante lo observado, se le colocó un pulsioxímetro y se salió a andar con ella....
Published: 2023
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3. Provoked exercise desaturation in patients with patent foramen ovale, infrequent or underdiagnosed?

Author: Víctor M. Juárez Olmos, Óscar González-Fernández, Alfonso Jurado Román, Santiago Jiménez Valero, Cristina Contreras Lorenzo, and Almudena Castro Conde
Subjects: Medicine
Abstract: To the Editor, The patent oval foramen (PFO) is present in nearly 1 out of every 4 people, and for the vast majority of them, it has no clinical implications.1 In others, however, it can trigger strokes, migraines or the orthostatic decompression or desaturation syndrome (known as platypnea-orthodeoxia syndrome).2 An even rarer presentation of PFO that can occur in the adult age is exercise-induced desaturation, which has been described in very few literature reviews and with a term not fully coined.3,4 This is the case of a 79-year-old woman with a past medical history of hypertension and diabetes referred to the cardiac rehabilitation unit due to dyspnea and poor functional capacity. The patient had previously undergone various tests including transthoracic echocardiography, pulmonary function tests, computed tomography pulmonary angiography, and coronary catheterization, all of which showed no significant findings. The physical examination revealed oxygen saturation levels around 98%, blood test results were normal, and N-terminal pro-brain natriuretic peptide levels, 255 pg/mL. Atthe office, she complained of exertional dyspnea that had just appeared after walking from the waiting room to the office. Then, a pulse oximeter was placed on her, and she was told to go for a walk. Oxygen saturation progressively dropped down to...
Published: 2023
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4. Cambiando el paradigma: desde la rehabilitación cardiaca a la rehabilitación vascular

Author: Carlos Escobar, Raquel Campuzano, M. Rosa Fernández, Vicente Arrarte, and Almudena Castro
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2023
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5. Manejo de la fibrilación auricular no valvular desde la perspectiva del paciente en España

Author: Almudena Castro, Luciano Arochena, Maite San Saturnino, Carmen Aleix, Alexandra Solé, Natalia Malé, Clara Gabás-Rivera, and Luis Lizán
Subjects: Medicine (General), R5-920
Abstract: Resumen: Objetivo: Describir la percepción del paciente anticoagulado con fibrilación auricular no valvular (FANV) sobre el manejo de su enfermedad, según su tratamiento: antagonistas de la vitamina K (AVK) o anticoagulantes orales de acción directa (ACOD). Métodos: Estudio observacional realizado con asociaciones de pacientes españolas mediante un cuestionario específico, con: 1) variables sociodemográficas/clínicas; 2) información recibida sobre FANV y tratamiento actual; 3) preferencias por el tratamiento anticoagulante; y 4) carga del tratamiento y barreras de acceso al mismo. Resultados: Participaron 156 pacientes (35,9% ACOD, 64,1% AVK). El 73,4% deseaba participar en la decisión de su tratamiento, pero solo el 40,6% había sido involucrado (49,0% ACOD vs. 36,0% AVK; p = 0,044). Los pacientes indicaron cierto grado de desinformación sobre agentes de reversión (25,7%) y alternativas terapéuticas disponibles (19,3%).La satisfacción con su tratamiento actual era alta: 7,1/10 (DE: 2,1); (8,5 ACOD vs. 6,4 AVK; p
Published: 2019
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6. ADAPTACIÓN ESPAÑOLA DE LAS GUÍAS EUROPEAS DE 2016 SOBRE PREVENCIÓN DE LA ENFERMEDAD CARDIOVASCULAR EN LA PRÁCTICA CLÍNICA

Author: Miguel Ángel Royo-Bordonada, Pedro Armario, José María Lobos Bejarano, Juan Pedro-Botet, Fernando Villar Alvarez, Roberto Elosua, Carlos Brotons Cuixart, Olga Cortés, Benilde Serrano, Miguel Camafort Babkowski, Antonio Gil Núñez, Antonio Pérez, Antonio Maiques, Ana de Santiago Nocito, Almudena Castro, Eduardo Alegría, Ciro Baeza, María Herranz, Susana Sans, Pilar Campos, and Comité Español Interdisciplinario para la Prevención Cardiovascular
Subjects: Medicine, Public aspects of medicine, RA1-1270
Abstract: RESUMENLas VI Guías Europeas de Prevención Cardiovascular recomiendan combinar las estrategias poblacionales y de alto riesgo, con los cambios de estilo de vida como piedra angular de la prevención, y proponen la función SCORE para cuantificar el riesgo cardiovascular. Esta guía hace más hinca-pié en las intervenciones específicas de las enfermedades y las condiciones propias de las mujeres, las personas jóvenes y las minorías étnicas. No se re-comienda el cribado de aterosclerosis subclínica con técnicas de imagen no invasivas. La guía establece cuatro niveles de riesgo (muy alto, alto, mode-rado y bajo), con objetivos terapéuticos de control lipídico según el riesgo. La diabetes mellitus confiere un riesgo alto, excepto en sujetos con diabetes tipo 2 con menos de 10 años de evolución, sin otros factores de riesgo ni complicaciones, o con diabetes tipo 1 de corta evolución sin complicacio-nes. La decisión de iniciar el tratamiento farmacológico de la hipertensión arterial dependerá del nivel de presión arterial y del riesgo cardiovascular, teniendo en cuenta la lesión de órganos diana. Siguen sin recomendarse los fármacos antiplaquetarios en prevención primaria por el riesgo de sangrado. La baja adherencia al tratamiento exige simplificar el régimen terapéutico e identificar y combatir sus causas. La guía destaca que los profesionales de la salud pueden ejercer un papel importante en la promoción de intervenciones poblacionales y propone medidas eficaces, tanto a nivel individual como poblacional, para promover una dieta saludable, la práctica de actividad fí-sica, el abandono del tabaquismo y la protección contra el abuso de alcohol
Published: 2016

7. Small airway dysfunction in smokers with stable ischemic heart disease.

Author: Claudia Llontop, Cristina Garcia-Quero, Almudena Castro, Regina Dalmau, Raquel Casitas, Raúl Galera, Alberto Iglesias, Elisabet Martinez-Ceron, Joan B Soriano, and Francisco García-Río
Subjects: Medicine, Science
Abstract: A higher prevalence of airflow limitation (AL) has been described in patients with ischemic heart disease (IHD). Although small airway dysfunction (SAD) is an early feature of AL, there is little information about its occurrence in IHD patients. Our objective was to describe the prevalence of SAD in IHD patients, while comparing patient-related outcomes and future health risk among IHD patients with AL, SAD and normal lung function.In 118 consecutive smoking patients with stable IHD, comorbidities, utilization of healthcare resources, current treatment, blood biochemistry and health status were recorded. SAD was evaluated by impulse oscillometry, and pre- and post-bronchodilator spirometry was performed.The prevalence of AL and SAD were 20.3 (95% CI, 13.1-27.6%) and 26.3% (95% CI, 18.3-34.2%), respectively. Compared to the normal lung function group, patients with SAD and without AL had lower spirometric values, poorer quality of life and higher levels of C-reactive protein (CRP), as well as increased cardiovascular risk and more vascular age. In patients with normal spirometry, the presence of SAD was independently associated with pack-years, HDL-cholesterol and CRP levels.In patients with IHD, the presence of SAD is common and that it is associated with reduced health status and increased future cardiac risk.
Published: 2017
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8. Avances en el conocimiento de la disfunción endotelial y su aplicación en la práctica clínica

Author: Antonia Simón, Almudena Castro, and Juan Carlos Kaski
Subjects: Medicine
Published: 2001

9. Ética en la investigación clínica: qué debe saber antes de iniciar un estudio

Author: Prado, Armando Pérez De, primary, Conde, Almudena Castro, additional, and Ferreira-González, Ignacio, additional
Published: 2024
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10. Incidence of cardiovascular events in patients with stabilized coronary heart disease : the EUROASPIRE IV follow-up study

Author: De Bacquer, Dirk, De Smedt, Delphine, Kotseva, Kornelia, Jennings, Catriona, Wood, David, Rydén, Lars, Gyberg, Viveca, Shahim, Bahira, Amouyel, Philippe, Bruthans, Jan, Conde, Almudena Castro, Cífková, Renata, Deckers, Jaap W., De Sutter, Johan, Dilic, Mirza, Dolzhenko, Maryna, Erglis, Andrejs, Fras, Zlatko, Gaita, Dan, Gotcheva, Nina, Goudevenos, John, Heuschmann, Peter, Laucevicius, Aleksandras, Lehto, Seppo, Lovic, Dragan, Miličić, Davor, Moore, David, Nicolaides, Evagoras, Oganov, Raphael, Pajak, Andrzej, Pogosova, Nana, Reiner, Zeljko, Stagmo, Martin, Störk, Stefan, Tokgözoğlu, Lale, Vulic, Dusko, Wagner, Martin, and De Backer, Guy
Published: 2019

11. A longitudinal study on coping and emotional well-being in cardiac patients

Author: Pilar Sanjuán, Alejandro Magallares, Henar Arranz, and Almudena Castro
Subjects: Psychiatry and Mental health, Clinical Psychology, Applied Psychology
Abstract: Emotions and coping play a role in the prognosis of cardiac patients. This two-wave longitudinal study aims to analyze the ability of adaptive and maladaptive coping to predict the emotional well-being of cardiac patients after controlling for their functional physical capacity. Emotional well-being (positive and negative affect), coping strategies, and functional physical capacity were evaluated both at Time 1 (n = 253) and at Time 2 (n = 186), 8 weeks later. At Time 1, positive affect was positively predicted by adaptive coping and negatively predicted by maladaptive coping, while the opposite pattern was found when negative affect was considered. At Time 2, after controlling for sociodemographic variables and for negative affect and functional physical capacity at T1, negative affect was negatively predicted by adaptive coping and positively predicted by maladaptive coping. In addition, positive affect was only predicted by adaptive coping after controlling for functional physical capacity and positive affect at Time 1. Relationships between coping and emotional well-being remain after controlling for the functional physical capacity of cardiac patients, which has a big impact on their emotional state. Finally, it is suggested that specific modules to improve coping and emotional state of cardiac patients should be included in Cardiac Rehabilitation Programs.
Published: 2023
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12. Conocimiento del cardiólogo clínico sobre diabetes mellitus tipo 2 de alto riesgo. ¿Qué sabemos y cómo podemos mejorar?

Author: Vivencio Barrios, Raquel Campuzano Ruiz, Almudena Castro Conde, and Juan Cosín-Sales
Subjects: Cardiology and Cardiovascular Medicine
Published: 2022
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13. Sex differences in Cardiorenal Syndrome: Insights from CARDIOREN Registry

Author: Marta Cobo Marcos, Rafael de la Espriella, Jara Gayán Ordás, Isabel Zegrí, Antonia Pomares, Pau Llácer, Aleix Fort, Adriana Rodríguez Chavarri, Ana Méndez, Zorba Blázquez, Pedro Caravaca Pérez, Jorge Rubio Gracia, Alejandro Recio-Mayoral, Jose Manuel García Pinilla, Maria Jose Soler, Ramón Garrido González, Jose Luis Górriz, Miguel González Rico, Almudena Castro, and Julio Núñez
Subjects: Physiology (medical), Emergency Medicine, Cardiology and Cardiovascular Medicine
Published: 2023
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14. Comments on the 2021 ESC guidelines on cardiovascular disease prevention in clinical practice

Author: Vicente Arrarte, Raquel Campuzano, José Antonio Alarcón Duque, Guillermo Aldama, Vivencio Barrios, Clara Bonanad, Almudena Castro Conde, Rosa Fernández Olmo, José M. Gámez, Gabriela Guzmán-Martínez, Carmen Neiro Rey, David Vivas, Pablo Avanzas, Gemma Berga Congost, Araceli Boraita, Héctor Bueno, David Calvo, Victoria Delgado, Laura Dos, Ignacio Ferreira-Gonzalez, Juan José Gomez Doblas, Domingo Pascual Figal, Antonia Sambola, Ana Viana Tejedor, José Luis Ferreiro, and Fernando Alfonso
Subjects: Primary Prevention, Cardiovascular Diseases, Humans, General Medicine
Published: 2022
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15. 5. CONTROL DE LOS FACTORES DE RIESGO CARDIOVASCULAR EN UN ESTUDIO MULTICÉNTRICO DE PACIENTES CON INSUFICIENCIA CARDIACA: A CALL TO ACTION

Author: González, Ramón Garrido, Marcos, Marta Cobo, Macián, Carlos Collado, Conde, Almudena Castro, de la Espriella Juan, Rafael, Núñez, Julio, Reiriz, Isabel Zegrí, Ordás, Jara Gayán, Iborra, Pau Llácer, Bermejo, Zorba Blázquez, Méndez, Ana, Pérez, Pedro J. Caravaca, Fort, Aleix, Chaverri, Adriana Rodríguez, Pomares, Antonia, Gracia, Jorge Rubio, Recio-Mayoral, Alejandro, Pinilla, José Manuel García, and Cubero, Javier Segovia
Published: 2023
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16. 7. LIPOPROTEÍNA (A): ¿EL NUEVO FACTOR DE RIESGO CARDIOVASCULAR?

Author: García, Alejandro Lara, Santana, Borja Rivero, Gómez, José Raúl Moreno, García, Joaquín Vila, Muñoz, Lucía Canales, and Conde, Almudena Castro
Published: 2023
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17. Abordaje práctico de la semaglutida en el paciente con diabetes tipo 2

Author: Carlos Escobar, Almudena Castro, Jorge Francisco Gómez Cerezo, José Luis Górriz, Juan Carlos Obaya Rebollar, and Rocío Villar-Taibo
Subjects: Cardiology and Cardiovascular Medicine
Published: 2022
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18. Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients Treated with Glp-1 Receptor Agonists: A Multidisciplinary Expert Consensus

Author: Juan J. Gorgojo-Martínez, Pedro Mezquita-Raya, Juana Carretero-Gómez, Almudena Castro, Ana Cebrián-Cuenca, Alejandra de Torres-Sánchez, María Dolores García-de-Lucas, Julio Núñez, Juan Carlos Obaya, María José Soler, José Luis Górriz, Miguel Ángel Rubio-Herrera, Institut Català de la Salut, [Gorgojo-Martínez JJ] Department of Endocrinology and Nutrition, Hospital Universitario Fundación Alcorcón, Madrid, Spain. [Mezquita-Raya P, de Torres-Sánchez A] Department of Endocrinology and Nutrition, Hospital Universitario Torrecárdenas, Almería, Spain. [Carretero-Gómez J] Department of Internal Medicine, University Hospital of Badajoz, Badajoz, Spain. [Castro A] Department of Cardiology, University Hospital la Paz, IdiPAZ, Biomedical Research Center-Cardiovascular Diseases (CIBERCV-ISCIII), Madrid, Spain. [Cebrián-Cuenca A] Health Centre Casco Antiguo Cartagena, Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB), Cartagena, Spain. [Soler MJ] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II [ENFERMEDADES], enfermedades del sistema digestivo::enfermedades gastrointestinales [ENFERMEDADES], acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::hipoglicemiantes [COMPUESTOS QUÍMICOS Y DROGAS], Aparell digestiu - Malalties, Other subheadings::Other subheadings::/adverse effects [Other subheadings], General Medicine, Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [DISEASES], Digestive System Diseases::Gastrointestinal Diseases [DISEASES], Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores], Antidiabètics - Ús terapèutic, Diabetis no-insulinodependent, Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [CHEMICALS AND DRUGS]
Abstract: Gastrointestinal adverse events; Obesity; Type 2 diabetes Esdeveniments adversos gastrointestinals; Obesitat; Diabetis tipus 2 Eventos adversos gastrointestinales; Obesidad; Diabetes tipo 2 Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are indicated in type 2 diabetes and obesity for their high efficacy in controlling glycaemia and inducing body weight loss, respectively. Patients may develop gastrointestinal adverse events (GI AEs), namely nausea, vomiting, diarrhoea and/or constipation. To minimize their severity and duration, healthcare providers (HCPs) and patients must be aware of appropriate measures to follow while undergoing treatment. An expert panel comprising endocrinologists, nephrologists, primary care physicians, cardiologists, internists and diabetes nurse educators convened across virtual meetings to reach a consensus regarding these compelling recommendations. Firstly, specific guidelines are provided about how to reach the maintenance dose and how to proceed if GI AEs develop during dose-escalation. Secondly, specific directions are set about how to avoid/minimize nausea, vomiting, diarrhoea and constipation symptoms. Clinical scenarios representing common situations in daily practice, and infographics useful to guide both HCPs and patients, are included. These recommendations may prevent people with T2D and/or obesity from withdrawing from GLP-1 RAs treatment, thus benefitting from their superior effect on glycaemic control and weight loss. This work has been funded by Novo-Nordisk.
Published: 2022

19. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author: Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah 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Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, María Dolores Martínez-Ruíz, María Fernanda Canales, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Mona Bhatia, Monica Rosca, Monika Laukyte, Montserrat Gracida Blanca, Montserrat Vila Perales, Mouaz H Al-Mallah, Moysés de Oliveira Filho, Mpiko Ntsekhe, Muhamed Saric, Mulei Chen, Myriam Brousseau, Myrthes Emy Takiuti, Nada Cemerlic-Adjic, Nadia Asif, Nadia Gakou, Nafisa Hussain, Nana O Katamadze, Nancy L Clapp, Nancy Aedy, Nandita Nataraj, Nanette K Wenger, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Natalie Spitzer, Natasha C Putnam, Naved Aslam, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Nevena Garcevic, Ngaire Meadows, Nhi N Tran, Nicholas Danchin, Nicki Lakeman, Nicola Johnston, Nicolas W Shammas, Nicole Saint Vrestil, Nicole Deming, Nier Zhong, Niket Patel, Nikola N Boskovic, Nikolaos Karogiannis, Nikos Werner, Nina Johnston, Ning Zhang, Ning Zhou, Niree Hindoyan, Nirmal Kumar, Nitika Chadha, Nitish Naik, Nodira Aripova, Noloyiso Mtana, Nona A Eskelson, Noor Syamira Mokhtar, Noppon Taksaudom, Nor Asiah Basri, Nora Marchelletta, Norma Hogg, Nungshi Jungla, Nuno Ferreira, Oksana A Lubyanaya, Olga B Nikolaeva, Olga Cañavate, Olga Sobrino, Olga Walesiak, Olga Walter, Olga Zdończyk, Olivia J Lim, Olivia Anaya, Olivia Mancilla, Olivier Dubourg, Olugbenga Bello, Omar Almousalli, Omar Thompson, Oni Olurinde, Or Harel, Osama Raheem, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, P Christian Schulze, Pachara Panpunuan, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Julian, Pamela Ouyang, Pamela Sigel, Pamela Woodard, Panpan Zhou, Paola Emanuela Poggio, Paola Smanio, Paolo Calabro, Paramjit Jeetley, Pascal Goube, Patricia K Nguyen, Patricia Alarie, Patricia Arakelian, Patricia Arsenault, Patricia Blaise, Patricia Brito, Patricia Cowper, Patricia Endsley, Patricia Mieses, Patrick B Alexander, Patrick Donnelly, Patrick Wilmot, Patrycja Lebioda, Paul C Gordon, Paul Der Mesropian, Paul Galiwango, Paul Hauptman, Paul Kennedy, Paula Beardsley, Paula García-González, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe Généreux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vučić, Radmila Lyubarova, Radoslaw Pracon, Raewyn Fisher, Rafael Beyar, Rafael Diaz, Rafael Selgas, Raffaele Bugiardini, Raffaele Fanelli, Raisa Kavalakkat, V S Rajalekshmi, Rajat S Barua, Rajeev Menon, Rajesh Gopalan Nair, Rajesh Francis, Rajiv Narang, Rakesh Yadav, Ralph Alan Huston, T Ramakrishnan, Ramesh de Silva, Rami El Mahmoud, Ramiro Carvalho, Ramon de Jesús-Pérez, Ramona Stevens, Ran Leng, Ranjan Kachru, Ranjit Kumar Nath, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Raymond W Little, Raymundo Ocaranza Sanchez, Rebecca J Wimmer, Rebecca Bariciano, Rebecca Otis, Rebekah R Herrmann, Reem Yunis, Reinette Hampson, Renato Abdala Karam, Renee C Hessian, Renee Kaneshiro, Reshma Ravindran, Reto Andreas Gamma, Reyna Bhandari, Reza Arsanjani, Ricardo L Lopes, Ricardo Mendes Oliveira, Ricardo Costa, Richa Bhatt, Richard F Davies, Richard H J Trimlett, Richard Goldweit, Rik Hermanides, Rine Nakanishi, Rinu R Sidh, Risha Patel, Rita Coram, Rizwan A Siddiqui, Rob S Beanlands, Robert J Hamburger, Robert K Riezebos, Robert M Donnino, Robert Bojar, Robert Chilton, Robert Guyton, Robert Henderson, Robert Kornberg, Robert Leber, Robert Mao, Robert Stenberg, Roberta P Santos, Roberto René Favaloro, Roberto Amati, Rodolfo G S D Lima, Rodrigo J Cerci, Rogerio Tumelero, Rohit Tandon, Roma Tewari, Romalisa Miranda-Peats, Ron Wald, Ronald A Mastouri, Ronald G Morford, Ronald G Schwartz, Ronald P Pedalino, Rongrong Hu, Ronnell A Hansen, Ronny A Cohen, Rory Hachamovitch, Rosa Homem, Rosa Sandonato, Rosane Laimer, Rosann Gans, Roxanne Yost, Roy Mathew, Rubén Baleón-Espinosa, Ruben Ramos, Rubine Gevorgyan, Rui Ferreira, Rui Jing, Ruth Pérez-Fernández, S K Dwivedi, S Ramakrishnan, Saadat Khan, Sabahat Bokhari, Sabu Thomas, Sadath Lubna, Sajeeda Parveen Khan, Sajeev Chakanalil Govindan, Saket Girotra, Saleem Kassam, Sallie Canada, Salvador Cruz-Flores, Samaa Mohamed, Samantha Ly, Sameh El Kaffas, Samia Massalha, Sampoornima Setty, Samuel Nwosu, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandra M Rivest, Sandra S Zier, Sandra Ahoud, Sandy Carr, Sanjay Ganapathi, Sanjay Shetty, Sanjeev Sharma, Santa Jimenez, Santhosh Satheesh, Santiago A Garcia, Sara Fernandez, Sara Karlsson, Sara Salkind, Sara Temiyasathit, Sarah Medina Rodriguez, Sarah Beaudry, Sarah Hadjih, Sarah Williams, Sarah Zahrani, Sarju Ralhan, Sasa Hinic, Sasko Kedev, Satinder Singh, Satoshi Yasuda, Satvic Cholenahally Manjunath, Sau Lee, Scott M Kaczkowski, Scott Kinlay, Sean W Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simović, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, Téodora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nuñez, Virginia Fernández-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-Ríos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek Pépin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
Subjects: Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract: BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
Published: 2020
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20. Factibilidad y resultados de un programa de rehabilitación cardiaca intensiva. Perspectiva del estudio aleatorizado MxM (Más por Menos)

Author: Manuel Abeytua, Iván J. Núñez-Gil, Regina Dalmau González-Gallarza, Almudena Castro-Conde, Joan Torres Marqués, Vicente Ignacio Arrarte Esteban, Pedro Caravaca Pérez, Rafael Hidalgo Urbano, Rafael Vidal-Pérez, and Fernando Garza Benito
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Introducción y objetivos Los programas de rehabilitación cardiaca (PRC) engloban intervenciones encaminadas a mejorar el pronóstico de la enfermedad cardiovascular influyendo en la condición física, mental y social de los pacientes, pero no se conoce su duración óptima. Nuestro objetivo es comparar los resultados de un PRC estándar frente a otro intensivo más breve tras un síndrome coronario agudo, mediante el estudio Más por Menos. Métodos Diseño prospectivo, aleatorizado, abierto, enmascarado a los evaluadores de eventos y multicéntrico (PROBE). Se aleatorizó a los pacientes al PRC estándar de 8 semanas u otro intensivo de 2 semanas con sesiones de refuerzo. Se realizó una visita final 12 meses después, tras la finalización del programa. Se evaluó: adherencia a la dieta, esfera psicológica, hábito tabáquico, tratamiento farmacológico, capacidad funcional, calidad de vida, parámetros cardiometabólicos y antropométricos, eventos cardiovasculares y mortalidad por cualquier causa durante el seguimiento. Resultados Se analizó a 497 pacientes (media de edad, 57, 8 ± 10, 0 años; el 87, 3% varones; programa intensivo, n = 262; estándar, n = 235). Las características basales de ambos grupos eran similares. Al año, más del 93% había mejorado en al menos 1 MET el resultado de la ergometría. Además, la adherencia a la dieta mediterránea y la calidad de vida mejoraron significativamente con el PRC, sin diferencias significativas entre grupos. Los eventos cardiovasculares ocurrieron de manera similar en ambos grupos. Conclusiones La PRC intensiva podría ser tan efectiva como la PRC estándar en lograr la adherencia a las medidas de prevención secundaria y ser una alternativa para algunos pacientes y centros. Introduction and objectives: Cardiac rehabilitation programs (CRP) are a set of interventions to improve the prognosis of cardiovascular disease by influencing patients’ physical, mental, and social conditions. However, there are no studies evaluating the optimal duration of these programs. We aimed to compare the results of a standard vs a brief intensive CRP in patients after ST-segment elevation and non–ST-segment elevation acute coronary syndrome through the Más por Menos study (More Intensive Cardiac Rehabilitation Programs in Less Time). Methods: In this prospective, randomized, open, evaluator-blind for end-point, and multicenter trial (PROBE design), patients were randomly allocated to either standard 8-week CRP or intensive 2-week CRP with booster sessions. A final visit was performed 12 months later, after completion of the program. We assessed adherence to the Mediterranean diet, psychological status, smoking, drug therapy, functional capacity, quality of life, cardiometabolic and anthropometric parameters, cardiovascular events, and all-cause mortality during follow-up. Results: A total of 497 patients (mean age, 57.8 ± 10.0 years; 87.3% men) were finally assessed (intensive: n = 262; standard: n = 235). Baseline characteristics were similar between the 2 groups. At 12 months, the results of treadmill ergometry improved by = 1 MET in = 93% of the patients. In addition, adherence to the Mediterranean diet and quality of life were significantly improved by CRP, with no significant differences between the groups. The occurrence of cardiovascular events was similar in the 2 groups. Conclusions: Intensive CRP could be as effective as standard CRP in achieving adherence to recommended secondary prevention measures after acute coronary syndrome and could be an alternative for some patients and centers. Registered at ClinicalTrials.gov (Identifier: NCT02619422).
Published: 2021
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21. Estratificación, monitorización y control del riesgo cardiovascular en pacientes con cáncer. Documento de consenso de SEC, FEC, SEOM, SEOR, SEHH, SEMG, AEEMT, AEEC y AECC

Author: Laura Torres Royo, Cristina Mitroi, Ana Martín García, Regina Dalmau, Gerard Oristrell, Yasmin Drak Hernández, Juan Cosín-Sales, Juan Tamargo, Meritxell Arenas, Raúl Córdoba, Francisco Ayala de la Peña, Sonia Velasco del Castillo, José Luis Palma Gámiz, Antonio Castro Fernández, Clara Bonanand Lozano, Manuel Anguita Sánchez, Belén Toral, Dimpna C. Albert, Luis Reinoso-Barbero, Estíbaliz García Rodríguez, Isabel Rodriguez, Isabel Egocheaga Cabello, Pascual Marco Vera, Marinela Chaparro-Muñoz, Eduardo Zatarain-Nicolás, Teresa Lozano, Milagros Pedreira, Pablo Díez-Villanueva, Vicente Ignacio Arrarte Esteban, Teófila Vicente-Herrero, J. Antolín, Dolores Mesa, Teresa Fernández, Carlos Escobar Cervantes, Almudena Castro, Lucía Deiros Bronte, Concepción Fernández Redondo, Amparo Martínez Monzonis, Pilar Mazón Ramos, Ramón García Sanz, and J. A. Virizuela
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen El incremento de la supervivencia del enfermo con cancer, junto con el desarrollo de nuevas terapias antitumorales, han puesto de relieve el impacto negativo que las complicaciones vasculares asociadas con el tratamiento oncohematologico tienen en la salud cardiovascular del paciente con cancer. El objetivo de este documento de consenso, promovido por el Grupo de Trabajo de Cardio-oncologia de la Sociedad Espanola de Cardiologia (SEC) y elaborado conjuntamente con diferentes areas de conocimiento de la SEC junto con la Sociedad Espanola de Hematologia y Hemoterapia (SEHH), la Sociedad Espanola de Oncologia Medica (SEOM), la Sociedad Espanola de Oncologia Radioterapica (SEOR), la Sociedad Espanola de Medicos Generales y de Familia (SEMG), la Asociacion Espanola de Especialistas en Medicina del Trabajo (AEEMT), la Asociacion Espanola de Enfermeria Cardiovascular (AEEC), la Fundacion Espanola del Corazon (FEC) y la Asociacion Espanola contra el Cancer (AECC), es proporcionar un enfoque coordinado, multidisciplinar y practico para la estratificacion, la monitorizacion y el tratamiento del riesgo cardiovascular de los pacientes con cancer.
Published: 2021
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22. Cardiovascular prevention in elderly patients

Author: Clara, Bonanad, Rosa, Fernández-Olmo, Sergio, García-Blas, Jose Antonio, Alarcon, Pablo, Díez-Villanueva, Carmen Rus, Mansilla, Héctor, García-Pardo, Pablo, Toledo, Ana, Ayesta, Eva, Pereira, Antoni, Carol, Almudena, Castro-Conde, Carmen, de Pablo-Zarzoso, Manuel, Martínez-Sellés, Vicente, Arrarte, Raquel, Campuzano, and Albert, Ariza-Solé
Abstract: In recent decades, life expectancy has been increasing significantly. In this scenario, health interventions are necessary to improve prognosis and quality of life of elderly with cardiovascular risk factors and cardiovascular disease. However, the number of elderly patients included in clinical trials is low, thus current clinical practice guidelines do not include specific recommendations. This document aims to review prevention recommendations focused in patients ≥ 75 years with high or very high cardiovascular risk, regarding objectives, medical treatment options and also including physical exercise and their inclusion in cardiac rehabilitation programs. Also, we will show why geriatric syndromes such as frailty, dependence, cognitive impairment, and nutritional status, as well as comorbidities, ought to be considered in this population regarding their important prognostic impact.
Published: 2022

23. Tratamiento hipolipemiante en los pacientes con enfermedad cardiovascular de riesgo muy elevado. Documento de consenso SEC sobre las indicaciones de los iPCSK9 en la práctica clínica

Author: X. Pintó Sala, Vicente Arrarte, E. López de Sa, A Cordero, Angel Cequier, J L Zamorano, Xavier Garcia-Moll, M.R. Fernández Olmo, L. Rodríguez Padial, J.L. López Sendón, Raquel Campuzano, Julio Núñez, Almudena Castro, J.R. González Juanatey, Manuel Anguita, J. Cosin, and J.J. Gómez Doblas
Subjects: Secondary prevention, Gynecology, Cardiovascular event, medicine.medical_specialty, business.industry, Patient subgroups, medicine.disease, Clinical Practice, Ezetimibe, medicine, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, business, PCSK9 Inhibitors, Dyslipidemia, Lipoprotein cholesterol, medicine.drug
Abstract: Different primary and secondary prevention studies have documented that a greater degree of reduction in low-density lipoprotein cholesterol (LDL-C) levels is associated with a greater decrease in cardiovascular event rates. PCSK9 inhibitors achieve important, rapid and sustained decreases in LDL-C. New clinical practice guidelines for the management of dyslipidemia establish reduced target levels of LDL-C. These goals are hardly achievable with a statin-only treatment, even in combination with ezetimibe. The addition of PCSK9 inhibitors can play a determining role in achieving these recommendations. However, it is important to identify the patient subgroups that can most benefit from this marked reduction in LDL-C levels. This document describes the profiles of patients with cardiovascular disease in which the maximum decrease in LDL-C levels should be a priority objective, considering strategies to achieve these levels and to facilitate the judicious use of these new drugs.
Published: 2021
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24. Comments on the 2019 ESC/EAS guidelines for the management of dyslipidemias

Author: Leopoldo Pérez de Isla, Lluís Masana, Rosa Argüeso, Raquel Campuzano, Isabel Egocheaga, Carlos Escobar, Lorenzo Fácila, Pedro Mata López, Miriam Rossi, Carmen Rus Mansilla, José Antonio Alarcón Duque, Vicente Arrarte, Gonzalo Barón, Vivencio Barrios, Amelia Carro, Almudena Castro, Juan Cosin-Sales, Rosa Fernández Olmo, José Gámez Martínez, Ana Huelmos, Miriam Sandín, Adriana Saltijeral, Alfonso Valle, Fernando Arribas, Gemma Berga Congost, Héctor Bueno, Arturo Evangelista, Ignacio Ferreira-González, Manuel Jiménez Navarro, Francisco Marín, Antonia Sambola, Rafael Vázquez, Ana Viana-Tejedor, Borja Ibáñez, and Fernando Alfonso
Subjects: medicine.medical_specialty, business.industry, Family medicine, MEDLINE, Medicine, General Medicine, business
Published: 2020
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25. Comments on the 2019 ESC guidelines on diabetes, prediabetes, and cardiovascular disease

Author: Manuel Jiménez Navarro, Almudena Castro, Sara Ballesteros Pradas, Concepción Cruzado Álvarez, Juan José Gómez Doblas, Domingo Marzal Martín, Susana del Prado, Félix Valencia Serrano, Irene Bretón, Fernando Gómez Peralta, Didac Mauricio, Alfonso Soto González, Vivencio Barrios, Alberto Cordero, Juan Cosin-Sales, Xavier García-Moll, José María García Pinilla, Pilar Jiménez Quevedo, Julio Núñez Villota, Rafael Romaguera Torres, Fernando Arribas, Gemma Berga Congost, Héctor Bueno, Arturo Evangelista, Ignacio Ferreira-González, Francisco Marín, Leopoldo Pérez de Isla, Antonia Sambola, Rafael Vázquez, Ana Viana-Tejedor, Borja Ibáñez, and Fernando Alfonso
Subjects: medicine.medical_specialty, business.industry, Diabetes mellitus, Internal medicine, medicine, General Medicine, Disease, Prediabetes, medicine.disease, business
Published: 2020
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26. Selección de lo mejor del año 2019 en riesgo vascular y rehabilitación cardiaca

Author: Vicente Arrarte, Raquel Campuzano, Amelia Carro, Almudena Castro, Regina Dalmau, Miriam Sandín, Elisa Velasco, and Alfonso Valle
Subjects: Cardiology and Cardiovascular Medicine
Published: 2020
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27. Impacto del tratamiento de la periodontitis en las enfermedades cardiovasculares, aproximación del big data: estudio PeriodCar

Author: Domingo Marzal, Miguel Antón, Manuel Anguita, Iván J. Núñez-Gil, Luis Rodríguez-Padial, and Almudena Castro
Subjects: business.industry, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2021
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28. Consenso de expertos en la coordinación de la rehabilitación cardiaca entre cardiología y atención primaria. Proyecto RehaCtivAP

Author: Rosa Fernández, Oona Meroño, Mercedes Lasa, Alfonso Valle, Alberto Calderón, Teresa Manjón, Almudena Castro, José Antonio Alarcón, Raquel Campuzano, Juan Carlos Obaya, Carolina de Tiedra, and Vicente Arrarte
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen En la continuidad asistencial del paciente que ha sufrido un sindrome coronario agudo es fundamental la rehabilitacion cardiaca. Es mas, centrar los cuidados en el paciente obliga a coordinar la atencion cardiologica con atencion primaria para mejorar la adherencia a los programas y una atencion continua adecuada. Los programas de rehabilitacion cardiaca comunitaria son indispensables para cumplir con los objetivos preventivos, pero somos conscientes de las dificultades de implementacion y la necesidad de apoyo de gestores y especialistas. Debemos ayudar a concienciar sobre esta necesidad y apoyar a los especialistas que tengan iniciativas en la creacion de este tipo de programas. Este documento trata de sintetizar los puntos basicos de la atencion y la coordinacion entre cardiologia y atencion primaria para la creacion y el desarrollo de estos programas comunitarios.
Published: 2020
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29. Consenso de expertos en la asistencia multidisciplinaria y el abordaje integral de la insuficiencia cardiaca. Desde el alta hospitalaria hasta la continuidad asistencial con primaria

Author: Alfonso Valle, Fernando Garza, Luis Almenar, María José Sanz, Raquel Campuzano, Juan Carlos Castillo Domínguez, Rosa Fernández, Eva Pereira, Antonio García Quintana, Marisa Crespo, Javier Mora, Paz Sanz, Javier Segovia, María Inés Gómez, Paola Beltrán, Carlos Peña Gil, Sergio Hevia, Maruan Chabbar, Garazi Oria, Ramón Bover, Vicente Miró, Juan José Gavira, Alejandro Recio, Vicente Arrarte, Carmen de Pablo, José Antonio Alarcón, Xavier Armengol, José Luis Lambert, José Manuel García Pinilla, Maruja Bello, Ángel Montiel, Carolina Ortiz, and Almudena Castro
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Abstract: Resumen La insuficiencia cardiaca es una enfermedad que precisa un tratamiento multidisciplinario, dadas la diversidad de causas y entornos clinicos implicados que las tratan y las diferentes estrategias terapeuticas que precisan la participacion indispensable de diversas disciplinas. La presencia en los servicios de cardiologia de unidades de insuficiencia cardiaca centradas en el tratamiento de los pacientes con esta afeccion y unidades de rehabilitacion cardiaca que, entre sus indicaciones para la reduccion de la morbimortalidad, tambien estan implicadas en la atencion de esos mismos pacientes puede causar dificultades de coordinacion y perdida de una atencion integral centrada en el paciente. Por estos motivos, en el presente documento se plantea una estrategia de coordinacion entre las diferentes unidades implicadas en el tratamiento de los pacientes dentro de los servicios de cardiologia y la continuidad asistencial con atencion primaria, tanto tras haber conseguido la estabilidad como la interrelacion para una coordinacion posterior mas efectiva.
Published: 2020
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30. Recomendaciones de seguimiento a partir del «cuarto trimestre» de mujeres con complicaciones vasculares y metabólicas durante el embarazo. Documento de consenso de la SEC, SEMERGEN, semFYC y SEGO

Author: Domingo Marzal Martín, M. Cruz Seoane Vicente, Ángel Castellanos Rodríguez, Juan Luis Delgado Marín, Juan Carlos Obaya, María Goya, Nuria Martínez Sánchez, Juan José Gorgojo, Almudena Castro Conde, Vicente Ignacio Arrarte Esteban, Santiago Díaz Sánchez, Ana Moyá Amengua, and Vicente Pallarés Carratalá
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Resumen El embarazo es predictor de riesgo cardiovascular futuro que puede desenmascarar trastornos metabolicos o vasculares latentes. El retraso en la edad reproductiva y su asociacion a otros factores de riesgo han incrementado los embarazos con complicaciones medicas. Actualmente existe un excelente protocolo nacional de atencion continuada a las mujeres que desarrollan estas complicaciones durante el embarazo. Pero tras el parto se inicia este periodo llamado «cuarto trimestre», que hace referencia al resto de la vida de la mujer tras el embarazo y donde disminuye el seguimiento. El objetivo de este documento es establecer recomendaciones en el «cuarto trimestre», avaladas por la Sociedad Espanola de Obstetricia y Ginecologia (SEGO), la Sociedad Espanola de Medicos de Atencion Primaria (SEMERGEN), la Sociedad Espanola de Medicina de Familia y Comunitaria (semFYC) y la Sociedad Espanola de Cardiologia (SEC), para asegurar el seguimiento de los factores de riesgo y potenciales complicaciones cardiovasculares que puedan desarrollarse a partir del «cuarto trimestre».
Published: 2020
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31. Abordaje integral del paciente con diabetes mellitus tipo 2 y enfermedad cardiovascular o de muy alto riesgo cardiovascular

Author: Juan José Gómez Doblas, Regina Dalmau González-Gallarza, M. José Soler, Carlos Morillas Ariño, Juan Carlos Obaya, Xavi García-Moll, Vicente Arrarte, Almudena Castro Conde, M. Rosa Fernández Olmo, Domingo Marzal Martín, Juan José Gorgojo, Raquel Campuzano, Pilar Mazón, and José Luis Górriz Teruel
Subjects: Nephrology, medicine.medical_specialty, Glucose control, business.industry, Type 2 Diabetes Mellitus, Disease, medicine.disease, Obesity, Diabetic nephropathy, Internal medicine, Diabetes mellitus, medicine, In patient, Cardiology and Cardiovascular Medicine, business, Intensive care medicine
Abstract: This document has been endorsed by the Diabetes and Obesity Working Group of the Spanish Society of Cardiology and the Diabetic Nephropathy Group of the Spanish Society of Nephrology. In this document on the management of patients with type 2 diabetes mellitus (T2DM) and cardiovascular disease or very high cardiovascular risk, it is intended to cover all aspects that should be considered in the treatment of these patients in order to reduce their cardiovascular risk and improve their clinical outcome. A new paradigm is being witnessed in the treatment of T2DM. The reduction of cardiovascular complications and mortality in patients with T2DM and cardiovascular disease, or high cardiovascular risk, goes beyond blood glucose control, and seems to be related more to the specific benefit provided by the new drugs. These include the group of sodium-glucose co-transporter type 2 inhibitors and the group of agonists of the glucagon-like peptide-1 receptor. The objective of this work is to update the document published by this working group at the beginning of 2018, and to provide information to specialties such, as cardiology and nephrology, on these new families of drugs that improve cardiovascular and renal prognosis
Published: 2019
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32. Selección de lo mejor del año 2018 en riesgo vascular y rehabilitación cardiaca

Author: Amelia Carro, Almudena Castro, Miriam Sandín, Regina Dalmau, Elisa Velasco, Raquel Campuzano, Vicente Arrarte, and Alfonso Valle
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Resumen 2020 es el ano de la pandemia de COVID-19, durante la cual los pacientes con enfermedad cardiovascular o factores de riesgo han tenido mayor morbimortalidad. Por ello, la prevencion cardiovascular y la rehabilitacion cardiaca (RC) se hacen mas imprescindibles que nunca. El tratamiento con farmacos protectores cardiovasculares y renales en diabetes es imparable y se actualiza en un nuevo algoritmo. El abandono del tabaco, control de la hipertension, dislipemia, sedentarismo y obesidad se consideran prioritarios. La e-medicina se ha implementado como nunca en prevencion; para llegar al maximo de pacientes, los programas de RC dejan de ser mayoritariamente presenciales para hacerse online y e-supervisados. La pandemia se convierte en una oportunidad para impulsar la prevencion y la RC, mas necesarias que nunca y para todos.
Published: 2019
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33. Health status after invasive or conservative care in coronary and advanced kidney disease

Author: Spertus J. A., Jones P. G., Maron D. J., Mark D. B., O'Brien S. M., Fleg J. L., Reynolds H. R., Stone G. W., Sidhu M. S., Chaitman B. R., Chertow G. M., Hochman J. S., Bangalore S, ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew Starovoytov, Andrzej Łabyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-Éric Gagné, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Björklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnación Alonso-Álvarez, Eric Daugas, Erick Alexánderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Flávia Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, François Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jesús Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaquín V Peñafiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-Iñiguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, María Dolores Martínez-Ruíz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Shinseki, Matthew Weir, Maura Carina Nédio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, 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G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, Sílvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, Téodora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fernández-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-Ríos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek Pépin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic, Spertus J.A., Jones P.G., Maron D.J., Mark D.B., O'Brien S.M., Fleg J.L., Reynolds H.R., Stone G.W., Sidhu M.S., Chaitman B.R., Chertow G.M., Hochman J.S., Bangalore S, and ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew Starovoytov, Andrzej Łabyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-Éric Gagné, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Björklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnación Alonso-Álvarez, Eric Daugas, Erick Alexánderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Flávia Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, François Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jesús Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaquín V Peñafiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-Iñiguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, María Dolores Martínez-Ruíz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Shinseki, Matthew Weir, Maura Carina Nédio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, Sílvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, Téodora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fernández-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-Ríos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek Pépin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
Subjects: Male, Intention to Treat Analysi, medicine.medical_treatment, Health Status, Myocardial Ischemia, 030204 cardiovascular system & hematology, Coronary Angiography, law.invention, Health Statu, 0302 clinical medicine, Randomized controlled trial, law, Surveys and Questionnaires, Odds Ratio, Surveys and Questionnaire, 030212 general & internal medicine, Myocardial infarction, Coronary Artery Bypass, medicine.diagnostic_test, General Medicine, Middle Aged, Intention to Treat Analysis, Cardiology, Female, Human, medicine.medical_specialty, Revascularization, Follow-Up Studie, 03 medical and health sciences, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, cardiovascular diseases, Healthy Lifestyle, Renal Insufficiency, Chronic, Proportional Hazards Models, Aged, Intention-to-treat analysis, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Odds ratio, medicine.disease, Angiography, Exercise Test, Proportional Hazards Model, business, Kidney disease, Follow-Up Studies
Abstract: BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of
Published: 2020

34. PETCO2 gradient: a novel prognostic parameter in cardiopulmonary exercise testing

Author: M.D Hernandez, H Arranz, I.D Poveda Pinedo, A.M Iniesta, L Pena, A Araujo, O Gonzalez, I Marco Clement, M Marin, I Ponz, S Espinosa, M.J Rodriguez, J L Lopez Sendon, Regina Dalmau, and Almudena Castro
Subjects: medicine.medical_specialty, Myocardial ischemia, Ejection fraction, business.industry, Cardiopulmonary exercise testing, medicine.disease, End tidal carbon dioxide concentration, Internal medicine, Heart failure, Hospital admission, Cardiology, Medicine, Carbon dioxide output, Cardiology and Cardiovascular Medicine, business, Heart failure with preserved ejection fraction
Abstract: Background Previous parameters such as peak VO2, VE/VCO2 slope and OUES have been described to be prognostic in heart failure (HF). The aim of this study was to identify further prognostic factors of cardiopulmonary exercise testing (CPET) in HF patients. Methods A retrospective analysis of HF patients who underwent CPET from January to November 2019 in a single centre was performed. PETCO2 gradient was defined by the difference between final PETCO2 and baseline PETCO2. HF events were defined as decompensated HF requiring hospital admission or IV diuretics, or decompensated HF resulting in death. Results A total of 64 HF patients were assessed by CPET, HF events occurred in 8 (12.5%) patients. Baseline characteristics are shown in table 1. Patients having HF events had a negative PETCO2 gradient while patients not having events showed a positive PETCO2 gradient (−1.5 [IQR −4.8, 2.3] vs 3 [IQR 1, 5] mmHg; p=0.004). A multivariate Cox proportional-hazards regression analysis revealed that PETCO2 gradient was an independent predictor of HF events (HR 0.74, 95% CI [0.61–0.89]; p=0.002). Kaplan-Meier curves showed a significantly higher incidence of HF events in patients having negative gradients, p=0.002 (figure 1). Conclusion PETCO2 gradient was demonstrated to be a prognostic parameter of CPET in HF patients in our study. Patients having negative gradients had worse outcomes by having more HF events. Time to first event, decompensated heart Funding Acknowledgement Type of funding source: None
Published: 2020
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35. Stratification and management of cardiovascular risk in cancer patients. A consensus document of the SEC, FEC, SEOM, SEOR, SEHH, SEMG, AEEMT, AEEC, and AECC

Author: Dimpna C. Albert, Sonia Velasco del Castillo, Belén Toral, Ana Martín García, Lucía Deiros Bronte, Juan Tamargo, Eduardo Zatarain-Nicolás, Meritxell Arenas, Milagros Pedreira, Isabel Rodriguez, Pascual Marco Vera, Ramón García Sanz, J. A. Virizuela, Dolores Mesa, Pilar Mazón Ramos, Vicente Ignacio Arrarte Esteban, J. Antolín, Teresa López Fernández, Raúl Córdoba, Isabel Egocheaga Cabello, Pablo Díez-Villanueva, Estíbaliz García Rodríguez, Manuel Anguita Sánchez, José Luis Palma Gámiz, Gerard Oristrell, Teresa Lozano, Yasmin Drak Hernández, Teófila Vicente-Herrero, Laura Torres Royo, Francisco Ayala de la Peña, Regina Dalmau, Juan Cosín-Sales, Antonio Castro Fernández, Luis Reinoso-Barbero, Carlos Escobar Cervantes, Concepción Fernández Redondo, Marinela Chaparro-Muñoz, Almudena Castro, Clara Bonanand Lozano, Cristina Mitroi, and Amparo Martínez Monzonis
Subjects: medicine.medical_specialty, Riesgo cardiovascular, Consensus, Cardiology, 030204 cardiovascular system & hematology, Medical Oncology, Occupational medicine, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Neoplasms, Radiation oncology, Hemotherapy, Medicine, Humans, Cardio oncology, Cardiotoxicidad, Cardiovascular nursing, business.industry, Cancer, General Medicine, Hematology, Cardiovascular risk, medicine.disease, Cardiotoxicity, Cancer treatment, Cardio-oncología, Cardio-oncology, Cardiovascular Diseases, Heart Disease Risk Factors, Family medicine, Radiation Oncology, business
Abstract: Both cancer treatment and survival have significantly improved, but these advances have highlighted the deleterious effects of vascular complications associated with anticancer therapy. This consensus document aims to provide a coordinated, multidisciplinary and practical approach to the stratification, monitoring and treatment of cardiovascular risk in cancer patients. The document is promoted by the Working Group on Cardio Oncology of the Spanish Society of Cardiology (SEC) and was drafted in collaboration with experts from distinct areas of expertise of the SEC and the Spanish Society of Hematology and Hemotherapy (SEHH), the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Radiation Oncology (SEOR), the Spanish Society of General and Family Physicians (SEMG), the Spanish Association of Specialists in Occupational Medicine (AEEMT), the Spanish Association of Cardiovascular Nursing (AEEC), the Spanish Heart Foundation (FEC), and the Spanish Cancer Association (AECC). (C) 2020 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
Published: 2020

36. Feasibility and results of an intensive cardiac rehabilitation program. Insights from the MxM (Más por Menos) randomized trial

Author: Iván J. Núñez-Gil, Regina Dalmau González-Gallarza, Almudena Castro-Conde, Vicente Ignacio Arrarte Esteban, Fernando Garza Benito, Pedro Caravaca Pérez, Rafael Vidal-Pérez, Rafael Hidalgo Urbano, Manuel Abeytua, and Joan Torres Marqués
Subjects: Quality of life, Male, medicine.medical_specialty, Acute coronary syndrome, Mediterranean diet, medicine.medical_treatment, Calidad de vida, Psychological intervention, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Multicenter trial, Internal medicine, medicine, LDL-cholesterol, Humans, Síndrome coronario agudo, cLDL, Prospective Studies, Treadmill, Acute Coronary Syndrome, Aged, Rehabilitation, Cardiac Rehabilitation, business.industry, Prevención secundaria, Secondary prevention, General Medicine, Middle Aged, medicine.disease, Dieta mediterránea, Rehabilitación cardiaca, Quality of Life, Feasibility Studies, Female, business
Abstract: Introduction and objectives Cardiac rehabilitation programs (CRP) are a set of interventions to improve the prognosis of cardiovascular disease by influencing patients’ physical, mental, and social conditions. However, there are no studies evaluating the optimal duration of these programs. We aimed to compare the results of a standard vs a brief intensive CRP in patients after ST-segment elevation and non–ST-segment elevation acute coronary syndrome through the Mas por Menos study (More Intensive Cardiac Rehabilitation Programs in Less Time). Methods In this prospective, randomized, open, evaluator-blind for end-point, and multicenter trial (PROBE design), patients were randomly allocated to either standard 8-week CRP or intensive 2-week CRP with booster sessions. A final visit was performed 12 months later, after completion of the program. We assessed adherence to the Mediterranean diet, psychological status, smoking, drug therapy, functional capacity, quality of life, cardiometabolic and anthropometric parameters, cardiovascular events, and all-cause mortality during follow-up. Results A total of 497 patients (mean age, 57.8 ± 10.0 years; 87.3% men) were finally assessed (intensive: n = 262; standard: n = 235). Baseline characteristics were similar between the 2 groups. At 12 months, the results of treadmill ergometry improved by ≥ 1 MET in ≥ 93% of the patients. In addition, adherence to the Mediterranean diet and quality of life were significantly improved by CRP, with no significant differences between the groups. The occurrence of cardiovascular events was similar in the 2 groups. Conclusions Intensive CRP could be as effective as standard CRP in achieving adherence to recommended secondary prevention measures after acute coronary syndrome and could be an alternative for some patients and centers. Registered at ClinicalTrials.gov (Identifier: NCT02619422).
Published: 2020

37. [Statement of the Spanish Interdisciplinary Vascular Prevention Committee on the updated European Cardiovascular Prevention Guidelines.]

Author: Ricard Tresserras, Miguel Ángel Royo-Bordonada, Pedro Armario, Almudena Castro, Antonio Pérez Pérez, Carlos Lahoz, Soledad Justo, María Alonso de Leciñana, Juan Pedro-Botet, María Herranz, Albert Clarà, Olga Cortés, Susana Aznar Laín, Ángel Díaz Rodriguez, Roberto Elosua, Carlos Brotons, and Rafael Santamaria
Subjects: medicine.medical_specialty, Population, Cardiology, Health Promotion, Medication Adherence, Cardiovascular prevention, Risk Factors, medicine, Humans, Vascular Diseases, Intensive care medicine, education, Exercise, Life Style, General Environmental Science, education.field_of_study, business.industry, Vascular disease, Incidence (epidemiology), PCSK9 Inhibitors, General Engineering, Type 2 Diabetes Mellitus, medicine.disease, Metformin, Diet, Clinical trial, Primary Prevention, Diabetes Mellitus, Type 2, Heart Disease Risk Factors, Cardiovascular Diseases, Spain, Hypertension, Practice Guidelines as Topic, General Earth and Planetary Sciences, Kidney Failure, Chronic, Smoking Cessation, business, medicine.drug, Kidney disease
Abstract: We present the adaptation for Spain of the updated European Cardiovascular Prevention Guidelines. In this update, greater stress is laid on the population approach, and especially on the promotion of physical activity and healthy diet through dietary, leisure and active transport policies in Spain. To estimate vascular risk, note should be made of the importance of recalibrating the tables used, by adapting them to population shifts in the prevalence of risk factors and incidence of vascular diseases, with particular attention to the role of chronic kidney disease. At an individual level, the key element is personalised support for changes in behaviour, adherence to medication in high-risk individuals and patients with vascular disease, the fostering of physical activity, and cessation of smoking habit. Furthermore, recent clinical trials with PCSK9 inhibitors are reviewed, along with the need to simplify pharmacological treatment of arterial hypertension to improve control and adherence to treatment. In the case of patients with type 2 diabetes mellitus and vascular disease or high vascular disease risk, when lifestyle changes and metformin are inadequate, the use of drugs with proven vascular benefit should be prioritised. Lastly, guidelines on peripheral arterial disease and other specific diseases are included, as is a recommendation against prescribing antiaggregants in primary prevention.Presentamos la adaptación para España de la actualización de las Guías Europeas de Prevención Vascular. En esta actualización se hace mayor énfasis en el abordaje poblacional, especialmente en la promoción de la actividad física y de una dieta saludable mediante políticas alimentarias y de ocio y transporte activo en España. Para estimar el riesgo vascular, se destaca la importancia de recalibrar las tablas que se utilicen, adaptándolas a los cambios poblaciones en la prevalencia de los factores de riesgo y en la incidencia de enfermedades vasculares, con particular atención al papel de la enfermedad renal crónica. A nivel individual resulta clave el apoyo personalizado para el cambio de conducta, la adherencia a la medicación en los individuos de alto riesgo y pacientes con enfermedad vascular, la promoción de la actividad física y el abandono del hábito tabáquico. Además, se revisan los ensayos clínicos recientes con inhibidores de PCKS9, la necesidad de simplificar el tratamiento farmacológico de la hipertensión arterial para mejorar su control y la adherencia al tratamiento. En los pacientes con diabetes mellitus 2 y enfermedad vascular o riesgo vascular alto, cuando los cambios de estilo de vida y la metformina resultan insuficientes, deben priorizarse los fármacos con demostrado beneficio vascular. Por último, se incluyen pautas sobre enfermedad arterial periférica y otras enfermedades específicas, y se recomienda no prescribir antiagregantes en prevención primaria.
Published: 2020

38. 3. REDUCCIÓN DE COMPLICACIONES CARDIOVASCULARES ASOCIADAS AL TRATAMIENTO CON ÁCIDO BEMPEDOICO: METANÁLISIS DE 4 ENSAYOS CLÍNICOS

Author: Fort, Alberto Cordero, Olmo, María Rosa Fernández, Santos-Gallego, Carlos García, Mañero, Moisés Rodríguez, Vázquez, José Mª Castellano, Rubio, Lorenzo Fácila, Lozano, Clara Bonanad, Conde, Almudena Castro, Martín, Domingo Marzal, González-Juanatey, Jose Ramón, Maestro, Lina Badimón, and Maestro, Juan José Badimon
Published: 2023
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39. 5. CONTROL DE FACTORES DE RIESGO EN PACIENTES CON ENFERMEDAD RENAL AVANZADA Y SÍNDROME CARDIORRENAL. DATOS DEL REGISTRO CARDIOREN

Author: González, Ramón Garrido, Marcos, Marta Cobo, Macián, Carlos Collado, Conde, Almudena Castro, de la Espriella Juan, Rafael, Núñez, Julio, Reiriz, Isabel Zegrí, Ordás, Jara Gayán, Iborra, Pau Llácer, Bermejo, Zorba Blazquez, Méndez, Ana, Pérez, Pedro J. Caravaca, Pal, Aleix Fort, Chaverri, Adriana Rodríguez, Pomares, Antonia, Gracia, Jorge Rubio, Recio-Mayoral, Alejandro, Pinilla, José Manuel García, Górriz, José Luis, Rico, Miguel González, and Cubero, Javier Segovia
Published: 2023
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40. 13. PREVALENCIA DE DISCORDANCIA ENTRE COLESTEROL LDL Y APOLIPOPROTEÍNA B EN UNA POBLACIÓN EN PREVENCIÓN SECUNDARIA CON TRATAMIENTO HIPOLIPEMIANTE DE ALTA INTENSIDAD

Author: Gálvez, Lucía Cobarro, González, Ricardo Martínez, Estremera, Blanca Fabre, Lorenzo, Cristina Contreras, Rodrigo, Clara Ugueto, Santamaría, Ainara Albaladejo, Muñoz, Mª Dolores Hernández, García, Lourdes Sánchez, Santana, Borja Rivero, Olmos, Víctor Manuel Juárez, Sánchez, Andrea Severo, López, Ana Torremocha, García, Jesús Saldaña, Gómez, José Raúl Moreno, and Conde, Almudena Castro
Published: 2023
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41. Uso de la polipíldora cardiovascular 40 mg en prevención cardiovascular secundaria

Author: Luis Rodríguez Padial, J. Cosin, Carlos Guijarro, Iñaki Lekuona, Domingo Marzal, Joan-Albert Arnáiz, and Almudena Castro
Subjects: Polypharmacy, Ramipril, medicine.medical_specialty, Aspirin, business.industry, Atorvastatin, Disease, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Cardiovascular prevention, Pill, medicine, Pharmacology (medical), 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, Intensive care medicine, Polypill, business, medicine.drug
Abstract: Controlling cardiovascular risk factors (CV) is essential for patients with cardiovascular disease. The CV polypill contains aspirin 100mg, atorvastatin 20mg or 40mg, and ramipril 2.5mg, 5mg or 10mg in a fixed combination pill. The objective was to review the evidence on the secondary prevention of cardiovascular disease, to establish the eventual patient profiles suitables to consider the use of CV polypill with atorvastatin 40mg in secondary CV prevention (P40PS), and to define the priority situations most adequate for the use of P40PS. A bibliographic review was carried out, which was complemented with the clinical opinion of 19 specialists. During hospitalization and discharge, P40PS is an option for patients admitted because of an atherothrombotic event, peripheral arterial disease, or other causes, and with the indication of the monocomponents. Its priority use is proposed in: prior intolerance to the highest dose of atorvastatin (80mg), age>75 years, low weight, stage 3 of chronic renal failure, hypothyroidism, drug interactions and Asian origin. Outside the hospital setting, the P40PS is a therapeutic alternative in patients with a need for secondary CV prevention and with indication to receive the monocomponents. The priority situations to receive the P40PS are: to be taking the three components separately, to require polypharmacy, lack of adherence or understanding of the treatment, and lack of control of CV risk factors. This work is the first with proposals for the use of P40PS and can facilitate the treatment of patients with cardiovascular disease in secondary prevention.
Published: 2018
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42. Use of the cardiovascular polypill 40 mg in secondary cardiovascular prevention

Author: Domingo Marzal, Luis Rodríguez Padial, Joan-Albert Arnáiz, Almudena Castro, Juan Cosín, Iñaki Lekuona, and Carlos Guijarro
Subjects: General Engineering, General Earth and Planetary Sciences, General Environmental Science
Published: 2018
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43. 15. CONTROL LIPÍDICO CON NUEVOS ÍNDICES ATEROGÉNICOS: EVALUACIÓN Y CAMBIOS DESDE LA UNIDAD CORONARIA A LA REHABILITACIÓN CARDIACA. ¿NOS PUEDEN AYUDAR A PREVENIR EVENTOS?

Author: González, Ricardo Martínez, García, Jesús Saldaña, López, Ana Torremocha, Gálvez, Lucía Cobarro, Lorenzo, Cristina Contreras, Rodrigo, Clara Ugueto, González-Gallarza, Regina Dalmau, Redondo, Emilio Arbas, Codón, Juan Caro, Rodríguez, Sandra Ofelia Rosillo, Romero, Eduardo R. Armada, Gómez, José Raúl Moreno, and Conde, Almudena Castro
Published: 2023
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44. Fatty acid profiles and omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) biosynthesis capacity of three dual purpose chicken breeds

Author: José Andrés Moreno Pérez, N. G. Acosta, Roberto Dorta-Guerra, Covadonga Rodríguez, Almudena Castro, A. Torres, and Carla Rolo
Subjects: chemistry.chemical_classification, 0303 health sciences, 030309 nutrition & dietetics, 010401 analytical chemistry, food and beverages, Fatty acid, Metabolism, 01 natural sciences, Eicosapentaenoic acid, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biosynthesis, Docosahexaenoic acid, lipids (amino acids, peptides, and proteins), Arachidonic acid, Docosapentaenoic acid, Food science, Food Science, Polyunsaturated fatty acid
Abstract: Westernized societies ingest an unhealthy high dietary omega-6/omega-3 fatty acid ratio of 20:1 or even higher. Seafood is the primary source of omega-3 long chain polyunsaturated fatty acids (LC-PUFA) for humans, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are involved in a plethora of physiological and health-related processes. However, the production of marine organisms with aquafeed formulations based on marine ingredients leads to serious environmental impacts on global pelagic fish resources, resulting in an unsustainable activity. The present study aims to gain further insight into the metabolism of fatty acids in chicken as a potential supply for omega-3 LC-PUFA. To this purpose, lipid classes and fatty acid profiles of thighs and hepatocytes, and the modification of [1-14C]18:3n-3 by hepatocytes isolated from three dual-purpose chicken breeds adapted to free-range culture systems were determined. Arachidonic acid highly accumulated in thighs meat (7.16-8.79%) despite being barely supplied in the diet, with DHA (1.22-1.71%) and n-3 docosapentaenoic acid (DPA, 22:5n-3; 1.02-1.14%) being also relevant. Our experimental design with radiolabeled fatty acids was validated for the first time in terrestrial vertebrates. Chicken hepatocytes incubated with [1-14C]18:3n-3 produced a wide variety of C18-C24 intermediates demonstrating that the set of fatty acyl desaturases and elongases enzymes necessary to metabolize dietary C18 precursors are active for the production of LC-PUFA, including EPA, n-3 DPA and DHA.
Published: 2021
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45. Comentarios a la guía ESC/EAS 2016 sobre el tratamiento de las dislipemias

Author: L. Pérez de Isla, Leopoldo Pérez de Isla, Pedro Luis Sánchez Fernández, Luis Álvarez-Sala Walther, Vivencio Barrios Alonso, Almudena Castro Conde, Enrique Galve Basilio, Luis García Ortiz, Pedro Mata López, Eduardo Alegría Ezquerra, Alberto Cordero Fort, Juan Cosin Sales, Carlos Escobar Cervantes, Xavier García-Moll Marimón, Juan José Gómez Doblas, Domingo Marzal Martín, Nekane Murga Eizagaechevarria, Carmen de Pablo Zarzosa, Luis Miguel Rincón, Juan Sanchis Forés, José Alberto San Román Calvar, Fernando Alfonso Manterola, Fernando Arribas Ynsaurriaga, Arturo Evangelista Masip, Ignacio Ferreira González, Manuel Jiménez Navarro, Francisco Marín Ortuño, Luis Rodríguez Padial, Alessandro Sionis Green, and Rafael Vázquez García
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine, business, Humanities
Published: 2017
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46. Comportamiento Climatológico del Primer Semestre del Año 2020 en Castilla - La Mancha.pdf

Author: Alonso, Francisco Javier Fernández, Lobera, Paloma Castro, and Lobera, Almudena Castro
Abstract: En esta publicación se pretende resumir el comportamiento climatológico (por primera vez) del primer semestre del año 2020, para los elementos temperatura y precipitación en una serie de observatorios principales de la Comunidad Autónoma de Castilla-La Mancha, relacionándolos con la situación de agua embalsada en cada una de las cinco provincias de la región. 2020 no solo está siendo el año de la COVID-19, sino que también tuvo una primavera especialmente húmeda en Castilla - La Mancha, lo que ha favorecido la producción agrícola de la región. Enero nos trajo a la Borrasca Gloria que también dejó su huella, especialmente en la provincia de Albacete.
Published: 2020
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47. Prevalence and Prognosis of Familial Hypercholesterolemia in Acute Coronary Syndromes Patients

Author: Alberto Cordero, Rosa M, Lidón, Almudena Castro, Lorenzo Fácila, Julio Nuñez, José Mostaza, and José Ramón González-Juanatey
Subjects: General Medicine
Published: 2020
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48. Comentario del CEIPV a la actualización de las Guías Europeas de Prevención Vascular en la Práctica Clínica

Author: Miguel Ángel Royo-Bordonada, Juan Pedro-Botet, Albert Clarà, Susana Aznar Laín, Almudena Castro, Rafael Santamaria, María Alonso de Leciñana, Soledad Justo, Pedro Armario, Roberto Elosua, Carlos Brotons, Antonio Pérez Pérez, Carlos Lahoz, María Herranz, Ricard Tresserras, Ángel Díaz Rodriguez, and Olga Cortés
Subjects: Arterial hypertension, medicine.medical_specialty, Population, Vascular risk, 030204 cardiovascular system & hematology, Enfermedades vasculares, 03 medical and health sciences, 0302 clinical medicine, Prevención y control, Internal Medicine, medicine, Pharmacology (medical), 030212 general & internal medicine, Intensive care medicine, education, Vascular diseases, education.field_of_study, Guías de práctica clínica, Vascular disease, business.industry, Incidence (epidemiology), Lipid control, Diabetes, Smoking, Control de lípidos. Tabaco, Type 2 Diabetes Mellitus, medicine.disease, Metformin, Clinical trial, Hipertensión arterial, Prevention and control, Tabaco, Healthy diet, Dieta saludable, Vascular disea-ses, business, Cardiology and Cardiovascular Medicine, Clinical practice guidelines, Arterial hy-pertension, Kidney disease, medicine.drug, Control de lípidos
Abstract: Publicación simultánea en las revistas órgano de expresión de las 15 sociedades científicas del CEIPV en soporte papel o electrónico en línea [ES] Presentamos la adaptación para España de la actualización de las Guías Europeas de Prevención Vascular. En esta actualización se hace mayor énfasis en el abordaje poblacional, especialmente en la promoción de la actividad física y de una dieta saludable mediante políticas alimentarias y de ocio y transporte activo en España. Para estimar el riesgo vascular, se destaca la importancia de recalibrar las tablas que se utilicen, adaptándolas a los cambios poblaciones en la prevalencia de los factores de riesgo y en la incidencia de enfermedades vasculares, con particular atención al papel de la enfermedad renal crónica. A nivel individual resulta clave el apoyo personalizado para el cambio de conducta, la adherencia a la medicación en los individuos de alto riesgo y pacientes con enfermedad vascular, la promoción de la actividad física y el abandono del tabaquismo. Además, se revisan los ensayos clínicos recientes con inhibidores de PCKS9, la necesidad de simplifi car el tratamiento farmacológico de la hipertensión arterial para mejorar su control y la adherencia al tratamiento. En los pacientes con diabetes mellitus 2 y enfermedad vascular o riesgo vascular alto, cuando los cambios de estilo de vida y la metformina resultan insufi cientes, deben priorizarse los fármacos con demostrado benefi cio vascular. Por último, se incluyen pautas sobre enfermedad arterial periférica y otras enfermedades específi cas y se recomienda no prescribir antiagregantes en prevención primaria. El objetivo del presente trabajo es realizar una revisión actualizada de la literatura con el propósito de ayudar a mejorar el conocimiento de esta patología [EN] We present the adaptation for Spain of the updated European Cardiovascular Prevention Guidelines. In this update, greater stress is laid on the population approach, and especially on the promotion of physical activity and healthy diet through dietary, leisure and active transport policies in Spain. To estimate vascular risk, note should be made of the importance of recalibrating the tables used, by adapting them to population shifts in the prevalence of risk factors and incidence of vascular diseases, with particular attention to the role of chronic kidney disease. At an individual level, the key element is personalized support for changes in behaviour, adherence to medication in high-risk individuals and patients with vascular disease, the fostering of physical activity, and cessation of smoking habit. Furthermore, recent clinical trials with PCSK9 inhibitors are reviewed, along with the need to simplify pharmacological treatment of arterial hypertension to improve control and adherence to treatment. In the case of patients with type 2 diabetes mellitus and vascular disease or high vascular disease risk, when lifestyle changes and metformin are inadequate, the use of drugs with proven vascular benefit should be prioritized. Lastly, guidelines on peripheral arterial disease and other specific diseases are included, as is a recommendation against prescribing antiaggregants in primary prevention. The objective of the present work is to carry out an updated review of the literature in order to help improve the knowledge of this pathology. Sí
Published: 2020

49. P687Is sacubitril/valsartan useful in patients with cancer and heart failure? Data from HF-COH Spanish multicenter registry

Author: J L Lopez Sendon, M Antunez Ballesteros, Pedro Moliner, Pedro L. Sánchez, Cristina Mitroi, Ana Martín-García, Teresa López-Fernández, A C Martin Garcia, C Asla, F Gual-Capllonch, C Sanchez-Pablo, A Martinez-Monzonis, Almudena Castro, I Marco, and M. Chaparro
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Heart failure, medicine, Cancer, In patient, Cardiology and Cardiovascular Medicine, medicine.disease, business, Sacubitril, Valsartan
Abstract: Current guidelines recommend sacubitril/valsartan (S/V) for patients (p.) with heart failure and reduced left ventricular ejection fraction (LVEF) but there is lack of evidence of its efficacy and safety in p. with cancer and heart failure. Our aim was to analyze the potential benefit of S/V in specific cardio-oncology clinics. Methods We performed a retrospective multicenter registry (HF-COH) in six Spanish hospitals with cardio-oncology clinics including all p. treated with S/V. Clinical and echocardiographic data, NYHA functional class, type of neoplasms and anti-tumoral treatment were described. Median follow-up was 7.2 [7.9] months. Results Sixty-one p. were included (median age was 64 [21] years old; 64%women, 43% hypertensive, 54% dyslipidemics and 28% diabetics). Most of p. (97%) had cancer therapy related cardiac dysfunction (CTRD) with a median time from anti-cancer therapy to CTRD of 40 [132] months. Breast (46%) and hematological (38%) cancers were the most frequent neoplasms, 31% of p. had metastatic disease and 71% had been treated with anthracyclines. In 5% S/V was initiated at CTRCD diagnosis while in 95% S/V was started to improve clinical status in p. already treated with ACE inhibitors or ARBs. 87% were on beta-blocker therapy and 74% on mineralocorticoid receptor antagonists.Maximal S/V titration dose was achieved in 8.2% of p. (24/26mg: 43%; 49/51mg: 33%) S/V was discontinued in 4 p. (reasons: 2 hypotension; 1: renal failure; 1: pruritus) Baseline NT-proBNP levels, functional class, and LVEF improved at the end of follow-up in p. who continued with S/V (all p values ≤0.01). No statistical differences were found in creatinine clearance or potassium serum levels. Table Patient parameters before and after S/V Before S/V After S/V P value LVEF (%) 33 [7] 39.5 [15] Conclusions Our experience suggests that S/V is well tolerated and improves functional class and left ventricular function parameters in patients with CTRCD.
Published: 2019
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50. Una historia resumida. La inhibición de la PCSK9 y su desarrollo clínico

Author: Almudena Castro, Jose Lopez-Sendon, and Regina Dalmau
Subjects: 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Cardiology and Cardiovascular Medicine
Abstract: Resumen La hipercolesterolemia es uno de los mas importantes factores de riesgo de enfermedades cardiovasculares, y no siempre es posible controlarla con los tratamientos convencionales: dieta, ejercicio y farmacos hipolipemiantes. La inhibicion de la proteina PCSK9 mediante anticuerpos monoclonales aumenta el numero de receptores de colesterol unido a lipoproteinas de baja densidad (cLDL) en el hepatocito y, por lo tanto, contribuye a su destruccion. Con estos farmacos, empleados solos o anadidos a estatinas o ezetimiba, se ha observado una reduccion del colesterol muy importante que permite mantener las cifras de cLDL de la mayoria de los pacientes en lo recomendado por las guias de practica clinica. Para averiguar su eficacia clinica, se han disenados 3 estudios multicentricos de morbimortalidad con alirocumab, evolocumab y bococizumab. En el estudio del evolocumab, un anticuerpo monoclonal 100% humano, se demostro una reduccion significativa del objetivo primario de eficacia, que incluia mortalidad cardiovascular, infarto agudo de miocardio, ictus, angina inestable o revascularizacion miocardica. Por el contrario, en el estudio con bococizumab, un anticuerpo humanizado, no 100% humano, no se observo beneficio clinico, lo que se atribuye a una disminucion de la eficacia secundaria a la creacion de anticuerpos contra el farmaco. Esta nueva opcion terapeutica ya esta disponible en la practica clinica y supone un nuevo avance en la prevencion de las enfermedades cardiovasculares.
Published: 2017
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