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26 results on '"Almeida, Marcos de Abreu"'

1. A Cluster of Diutina catenulata Funguria in Patients with Coronavirus Disease 2019 (COVID-19) Hospitalized in a Tertiary Reference Hospital from Rio de Janeiro, Brazil

Author

Almeida-Paes, Rodrigo, Teixeira, Marcus de Melo, Oliveira, Fernanda Alves de, Almeida, Marcos de Abreu, Almeida-Silva, Fernando, Geraldo, Kim Mattos, Nunes, Estevão Portela, Baker, Bridget M., Stajich, Jason E., Grinsztejn, Beatriz, Veloso, Valdilea Gonçalves, Freitas, Andrea d’Avila, and Zancopé-Oliveira, Rosely Maria

Published
2024
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4. Production of Secreted Carbohydrates that Present Immunologic Similarities with the Cryptococcus Glucuronoxylomannan by Members of the Trichosporonaceae Family: A Comparative Study Among Species of Clinical Interest

Author

de Andrade, Iara Bastos, Almeida, Marcos de Abreu, Figueiredo-Carvalho, Maria Helena Galdino, Coelho, Rowena Alves, Chaves, Alessandra Leal da Silva, Frases, Susana, Zancopé-Oliveira, Rosely Maria, Brito-Santos, Fábio, and Almeida-Paes, Rodrigo

Published
2021
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5. Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome

Author

Cruz, Ingrid Ludmila Rodrigues, Freitas, Dayvison Francis Saraiva, de Macedo, Priscila Marques, Gutierrez-Galhardo, Maria Clara, do Valle, Antonio Carlos Francesconi, Almeida, Marcos de Abreu, Coelho, Rowena Alves, Brito-Santos, Fábio, Figueiredo-Carvalho, Maria Helena Galdino, Zancopé-Oliveira, Rosely Maria, and Almeida-Paes, Rodrigo

Published
2021
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7. ESPOROTRICOSE: UMA MICOSE EM EXPANSÃO NO CEARÁ

Author

Damasceno, Lisandra Serra, primary, de Almeida Junior, Antônio Mauro Barros, additional, Farias, Luis Arthur Brasil Gadelha, additional, de Mesquita, Jacó Ricarte Lima, additional, Almeida, Marcos de Abreu, additional, de Almeida Paes, Rodrigo, additional, and Zancopé-Oliveira, Rosely Maria, additional

Published
2023
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8. CRIPTOCOCOSE: ASPECTOS CLÍNICOS E CARACTERIZAÇÃO DOS ISOLADOS FÚNGICOS DE PACIENTES INTERNADOS EM HOSPITAL REFERÊNCIA NO ESTADO DO CEARÁ

Author

Júnior, Antônio Mauro Barros Almeida, primary, Almeida, Marcos de Abreu, additional, Rabello, Vanessa Brito de Souza, additional, Paes, Rodrigo Almeida, additional, Oliveira, Rosely Maria Zancope, additional, Brito, Johnny do Nascimento, additional, Magalhães, Liana Ferreira, additional, Maciel, Letícia Sampaio, additional, Pontes, Lucas de Oliveira, additional, Guedes, Vitor Cavalcante, additional, Machado, Maria Tereza Pontes, additional, and Damasceno, Lisandra Serra, additional

Published
2023
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9. Paracoccidioidomycosis and pregnancy: A 40-year single-center cohort study in the endemic area of Rio de Janeiro, Brazil

Author

Benko, Lorena Macedo Pestana, primary, Vieira da Silva, Mariana Evangelista de Souza, additional, Falcão, Eduardo Mastrangelo Marinho, additional, Freitas, Dayvison Francis Saraiva, additional, Calvet, Guilherme Amaral, additional, Almeida, Marcos de Abreu, additional, Almeida-Paes, Rodrigo, additional, Zancopé-Oliveira, Rosely Maria, additional, do Valle, Antonio Carlos Francesconi, additional, and de Macedo, Priscila Marques, additional

Published
2023
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10. Development and validation of a new quantitative reverse transcription PCR assay for the diagnosis of human sporotrichosis

Author

Marques de Macedo, Priscila, primary, Sturny-Leclère, Aude, additional, Freitas, Dayvison Francis Saraiva, additional, Ghelfenstein-Ferreira, Theo, additional, Gutierrez-Galhardo, Maria Clara, additional, Almeida, Marcos de Abreu, additional, Rodrigues, Anderson Messias, additional, Pautet, Thierry, additional, Hamane, Samia, additional, Almeida-Paes, Rodrigo, additional, Zancopé-Oliveira, Rosely Maria, additional, and Alanio, Alexandre, additional

Published
2023
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11. Evaluation of Five Non-Culture-Based Methods for the Diagnosis of Meningeal Sporotrichosis

Author

Almeida-Silva, Fernando, primary, Almeida, Marcos de Abreu, additional, Rabello, Vanessa Brito de Souza, additional, Zancopé-Oliveira, Rosely Maria, additional, Baeza, Lilian Cristiane, additional, Lamas, Cristiane da Cruz, additional, Lima, Marco Antonio, additional, de Macedo, Priscila Marques, additional, Gutierrez-Galhardo, Maria Clara, additional, Almeida-Paes, Rodrigo, additional, and Freitas, Dayvison Francis Saraiva, additional

Published
2023
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13. Investigação de surto de Histoplasmose pulmonar aguda entre bombeiros em Brazlândia, Distrito Federal, 2017

Author

E Alves, Ana Julia Silva e, primary, Figueiredo, Josivânia Arrais, additional, Millington, Maria Adelaide, additional, Segatto, Teresa Cristina Vieira, additional, Cardoso, Alessandra Viana, additional, Von Glehn, Mateus De Paula, additional, Correia, Amabel Fernandes, additional, Wanke, Bodo, additional, Trilles, Luciana, additional, Oliveira, Rosely Maria Zancope, additional, Muniz, Mauro De Medeiros, additional, Almeida, Marcos De Abreu, additional, Junior, José Evoide De Moura, additional, and Wada, Marcelo Yoshito, additional

Published
2021
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15. Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome

Author

Cruz, Ingrid Ludmila Rodrigues, primary, Freitas, Dayvison Francis Saraiva, additional, de Macedo, Priscila Marques, additional, Gutierrez-Galhardo, Maria Clara, additional, do Valle, Antonio Carlos Francesconi, additional, Almeida, Marcos de Abreu, additional, Coelho, Rowena Alves, additional, Brito-Santos, Fábio, additional, Figueiredo-Carvalho, Maria Helena Galdino, additional, Zancopé-Oliveira, Rosely Maria, additional, and Almeida-Paes, Rodrigo, additional

Published
2020
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16. Postpartum histoplasmosis in an HIV-negative woman: a case report and phylogenetic characterization by internal transcribed spacer region analysis

Author

Damasceno,Lisandra Serra, Almeida Júnior,Antônio Mauro Barros, Aguiar,Bárbara de Oliveira, Muniz,Mauro de Medeiros, Almeida,Marcos de Abreu, Zancopé-Oliveira,Rosely Maria, and Leitão,Terezinha do Menino Jesus Silva

Subjects
Postpartum, ITS1-5.8S-ITS2, Histoplasmosis
Abstract

The present report describes the first case of postpartum disseminated histoplasmosis in a 24-year-old HIV-negative woman. On the tenth day after vaginal delivery, the patient presented with dyspnea, fever, hypotension, tachycardia, and painful hepatomegaly. Yeast-like Histoplasma capsulatum features were isolated in the buffy coat. The phylogenetic analysis demonstrated that the fungal isolate was similar to other H. capsulatum isolates identified in HIV patients from Ceará and Latin America. Thus, histoplasmosis development in individuals with transitory immunosuppression or during the period of immunological recovery should be carefully examined.

Published
2020

17. Postpartum histoplasmosis in an HIV-negative woman: a case report and phylogenetic characterization by internal transcribed spacer region analysis

Author

Damasceno, Lisandra Serra, primary, Almeida Júnior, Antônio Mauro Barros, additional, Aguiar, Bárbara de Oliveira, additional, Muniz, Mauro de Medeiros, additional, Almeida, Marcos de Abreu, additional, Zancopé-Oliveira, Rosely Maria, additional, and Leitão, Terezinha do Menino Jesus Silva, additional

Published
2020
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18. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Author

Macedo, Priscila Marques de, Almeida-Paes, Rodrigo, Almeida, Marcos de Abreu, Coelho, Rowena Alves, Oliveira Filho, Marcio Amaral de, Medeiros, Denise Machado, Gomes-Silva, Adriano, Lima, Jéssica Ribeiro de, Da-Cruz, Alda Maria, Zancopé-Oliveira, Rosely Maria, and Valle, Antonio Carlos Francesconi do

Subjects
Septic shock, Paracoccidioides brasiliensis S1, Host-parasite interaction
Abstract

The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process. Together with P. lutzii, P. brasiliensis appears to be involved in severe cases of PCM.

Published
2018

20. Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report

Author

Macedo, Priscila Marques de, primary, Almeida-Paes, Rodrigo, additional, Almeida, Marcos de Abreu, additional, Coelho, Rowena Alves, additional, Oliveira Filho, Marcio Amaral de, additional, Medeiros, Denise Machado, additional, Gomes-Silva, Adriano, additional, Lima, Jéssica Ribeiro de, additional, Da-Cruz, Alda Maria, additional, Zancopé-Oliveira, Rosely Maria, additional, and Valle, Antonio Carlos Francesconi do, additional

Published
2018
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21. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum

Author

Almeida-Paes, Rodrigo, primary, Almeida-Silva, Fernando, additional, Pinto, Gabriela Costa Maia, additional, Almeida, Marcos de Abreu, additional, Muniz, Mauro de Medeiros, additional, Pizzini, Claudia Vera, additional, Gerfen, Gary J, additional, Nosanchuk, Joshua Daniel, additional, and Zancopé-Oliveira, Rosely Maria, additional

Published
2017
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22. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum.

Author

Almeida-Paes, Rodrigo, Almeida-Silva, Fernando, Pinto, Gabriela Costa Maia, Almeida, Marcos de Abreu, Muniz, Mauro de Medeiros, Pizzini, Claudia Vera, Gerfen, Gary J, Nosanchuk, Joshua Daniel, and Zancopé-Oliveira, Rosely Maria

Abstract

Melanization of Histoplasma capsulatum remains poorly described, particularly in regards to the forms of melanin produced. In the present study, 30 clinical and environmental H. capsulatum strains were grown in culture media with or without L-tyrosine under conditions that produced either mycelial or yeast forms. Mycelial cultures were not melanized under the studied conditions. However, all strains cultivated under yeast conditions produced a brownish to black soluble pigment compatible with pyomelanin when grew in presence of L-tyrosine. Sulcotrione inhibited pigment production in yeast cultures, strengthening the hyphothesis that H. capsulatum yeast forms produce pyomelanin. Since pyomelanin is produced by the fungal parasitic form, this pigment may be involved in H. capsulatum virulence. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Validation of western blot for Histoplasma capsulatum antibody detection assay

Author

Almeida, Marcos de Abreu, primary, Pizzini, Cláudia Vera, additional, Damasceno, Lisandra Serra, additional, Muniz, Mauro de Medeiros, additional, Almeida-Paes, Rodrigo, additional, Peralta, Regina Helena Saramago, additional, Peralta, José Mauro, additional, Oliveira, Raquel de Vasconcelos Carvalhaes, additional, Vizzoni, Alexandre Gomes, additional, de Andrade, Carla Lourenço Tavares, additional, and Zancopé-Oliveira, Rosely Maria, additional

Published
2016
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25. Validation of western blot for Histoplasma capsulatum antibody detection assay.

Author

de Abreu Almeida, Marcos, Pizzini, Cláudia Vera, Serra Damasceno, Lisandra, de Medeiros Muniz, Mauro, Almeida-Paes, Rodrigo, Saramago Peralta, Regina Helena, Peralta, José Mauro, de Vasconcelos Carvalhaes Oliveira, Raquel, Gomes Vizzoni, Alexandre, de Andrade, Carla Lourenço Tavares, Zancopé-Oliveira, Rosely Maria, Almeida, Marcos de Abreu, Damasceno, Lisandra Serra, Muniz, Mauro de Medeiros, Peralta, Regina Helena Saramago, Oliveira, Raquel de Vasconcelos Carvalhaes, and Vizzoni, Alexandre Gomes

Subjects
HISTOPLASMOSIS diagnosis, HISTOPLASMA capsulatum, WESTERN immunoblotting, SYSTEMIC mycoses, IMMUNOASSAY
Abstract

Background: Histoplasmosis is worldwide systemic mycoses caused by the dimorphic fungus Histoplasma capsulatum. The isolation and identification of H. capsulatum in culture is the reference test for histoplasmosis diagnosis confirmation. However, in the absence of it, serology has been used as a presumptive diagnosis through antibody and antigen detection. The purpose of the present study was to validate an immunoassay method (western blot) for antibodies detection in the diagnosis of histoplasmosis.Methods: To validate the western blot (WB) a study was conducted using 118 serum samples from patients with histoplasmosis and 118 serum controls collected from January 2000 to December 2013 in residents of the Rio de Janeiro State, Brazil. Diagnostic validation parameters were calculated based on the categorization of results obtained in a 2 × 2 table and subjected to statistical analysis. In addition, the viability of deglycosylated histoplasmin antigen (ptHMIN) onto nitrocellulose membranes previously sensitized was evaluated during the same period.Results: The WB test showed sensitivity of 94.9 %, specificity of 94.1 %, positive predictive value of 94.1 %, negative predictive value of 94.9 %, accuracy of 94.5 %, and almost perfect precision. Besides, the strips have proved to be viable for using at least 5 years after ptHMIN antigen sensitization.Conclusion: Western blot test using ptHMIN provides sensitive, specific, and faster results. Therefore, could be considered a useful tool in the diagnosis of histoplasmosis being used by public health system, even in situations where laboratory facilities are relatively limited. [ABSTRACT FROM AUTHOR]

Published
2016
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26. Interactions of the emerging fungus Candida auris with Acanthamoeba castellanii reveal phenotypic changes with direct implications on the response to stress and virulence.

Author

Valente MR, Martins Alcântara L, Cintra DS, Mendoza SR, Medeiros EG, Gomes KX, Honorato L, Almeida MdA, Vieira CB, Nosanchuk JD, Sgarbi DBdG, Pinto MR, Nimrichter L, and Guimarães AJ

Abstract

Candida auris is an emerging fungal pathogen notable for its resistance to multiple antifungals and ability to survive in various environments. Understanding the interactions between C. auris and environmental protozoa, such as Acanthamoeba castellanii, could provide insights into fungal adaptability and pathogenicity. Two C. auris isolates (MMC1 and MMC2) were co-cultured with A. castellanii to examine interaction dynamics, survival, stress responses, growth, virulence, biofilm formation, and antifungal susceptibility. The association of C. auris-A. castellanii varied with a multiplicity of infection (MOI), with MMC2 exhibiting higher association rates at increased MOI than MMC1. Both isolates survived distinctly within A. castellanii , as the MMC1 showed an initial decline and subsequent increase in viability, while MMC2 maintained higher viability for up to 24 h, decreasing afterward. Both isolates exhibited accelerated growth when recovered from A. castellanii . The MMC2 isolate displayed increased resistance to oxidative, osmotic, and thermal stresses upon interaction with A. castellanii , whereas MMC1 showed limited changes. Exposure to A. castellanii also influenced the expression of virulence factors differently, with MMC1 increasing phospholipase and peptidase, while MMC2 upregulated phytase, esterase, hemolysin, and siderophores. Upon contact with A. castellanii , MMC2 enhanced biofilm formation, unlike MMC1. Both isolates increased ergosterol upon interactions, enhancing susceptibility to amphotericin B. However, both isolates were more tolerant to itraconazole and caspofungin, particularly MMC2, which showed differential expression of ergosterol biosynthesis enzymes and increased cell wall polysaccharides. This study reveals that interactions with A. castellanii modulate C. auris physiology and virulence, contributing to its environmental adaptability and resistance to antifungals., Importance: Candida auris has emerged as a critical public health concern due to its resistance to multiple antifungal drugs and ability to survive on surfaces under harsh conditions, mainly due to biofilm formation. The precise origin of this emerging pathogen still awaits elucidation, but interactions with environmental protozoa may have helped C. auris to develop such virulence and resistance traits. In this work, we precisely characterize the interactions of C. auris with the free-living amoeba Acanthamoeba castellanii and how these protozoa may alter the fungal behavior in terms of virulence, thermotolerance, biofilm formation capacity, and drug resistance. It may be essential to understand the various interactions C. auris could perform in the environment, directly impacting the outcome of human infections under the One Health approach.

Published
2024
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